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Journal articles on the topic 'UC'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 April 2022

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1

Dabbous, O., S. Yan, M. Bala, R. Arjunji, H. Thompson, B. Tang, J. Gdovin, and M. I. Rahman. "UC." American Journal of Gastroenterology 101 (September 2006): S407. http://dx.doi.org/10.14309/00000434-200609001-01036.

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2

Waite, Gloria. "UC Investment and UC Africanists (continued)." ASA News 19, no. 1 (March 1986): 32–33. http://dx.doi.org/10.1017/s0002021400040913.

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3

Brentnall, Teri. "UC FOR UC: URSODIOL CHEMOPREVENTION FOR ULCERATIVE COLITIS." Inflammatory Bowel Diseases 9, no. 5 (September 2003): 339. http://dx.doi.org/10.1097/00054725-200309000-00010.

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4

Lehman, W. F., V. L. Marble, and M. W. Nielson. "Registration of UC 176, UC 196, UC 226, UC 276, and UC 296 very Nondormant Alfalfa Germplasms with Varying Levels of Resistance to Diseases and/or Insects." Crop Science 32, no. 1 (January 1992): 285. http://dx.doi.org/10.2135/cropsci1992.0011183x003200010069x.

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5

Crooks, James E. "UC tries FirstSearch." College & Research Libraries News 53, no. 7 (July 1, 1992): 464. http://dx.doi.org/10.5860/crln.53.7.464.

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6

Beer, Gerald. "UC Spaces Revisited." American Mathematical Monthly 95, no. 8 (October 1988): 737. http://dx.doi.org/10.2307/2322255.

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7

Henner, D. "UC-Genentech Trial." Science 284, no. 5419 (May 28, 1999): 1465b—1465. http://dx.doi.org/10.1126/science.284.5419.1465b.

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8

Beer, Gerald. "UC Spaces Revisited." American Mathematical Monthly 95, no. 8 (October 1988): 737–39. http://dx.doi.org/10.1080/00029890.1988.11972080.

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9

Lehman, W. F., D. K. Barnes, F. I. Frosheiser, and V. L. Marble. "Registration of UC 189 and UC 231 very Nondormant Alfalfa Germplasms." Crop Science 32, no. 1 (January 1992): 285–86. http://dx.doi.org/10.2135/cropsci1992.0011183x003200010070x.

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10

Liwnicz, Boleslaw H., Gerald Archer, Shirley W. Soukup, and Regina G. Liwnicz. "Continuous human glioma-derived cell lines UC-11MG and UC-302MG." Journal of Neuro-Oncology 3, no. 4 (1986): 373–85. http://dx.doi.org/10.1007/bf00165588.

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11

Hasegawa, A., and H. Yamagami. "Electronic structure of UC." Journal of Magnetism and Magnetic Materials 90-91 (December 1990): 401–2. http://dx.doi.org/10.1016/s0304-8853(10)80143-x.

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12

SHOJI, Kan. "Ryan White Lab. @ UC." Denki Kagaku 88, no. 4 (December 5, 2020): 368–69. http://dx.doi.org/10.5796/denkikagaku.20-ot0053.

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13

Service, R. F. "Biotech: UC Milks It." Science 311, no. 5765 (March 3, 2006): 1229d. http://dx.doi.org/10.1126/science.311.5765.1229d.

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14

Alidadi, Nasser, Mohammad R. Mokhber Dezfouli, Mohammad Gholi Nadalian, Ali Rezakhani, and Iradj Nouroozian. "Ophthalmology at UC Davis." Journal of Equine Veterinary Science 22, no. 5 (May 2002): 186–89. http://dx.doi.org/10.1053/jevs.2002.34298.

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15

Dawson, Jim. "UC Gets LBNL Contract." Physics Today 58, no. 6 (June 2005): 30. http://dx.doi.org/10.1063/1.4797058.

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16

Ochsner, Nancy. "UC Merced's inaugural class." New Directions for Higher Education 2007, no. 139 (2007): 127–34. http://dx.doi.org/10.1002/he.273.

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17

Green, Rebecca. "RoweCom at UC Berkeley." Serials Review 25, no. 2 (June 1999): 9–21. http://dx.doi.org/10.1080/00987913.1999.10764501.

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18

Lennard-Jones, J. E., J. K. Ritchie, and D. M. Melville. "Colorectal cancer in UC." Gut 29, no. 9 (September 1, 1988): 1291–92. http://dx.doi.org/10.1136/gut.29.9.1291.

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19

McGuckin, Michael A., and Sumaira Z. Hasnain. "There is a ‘uc’ in mucus, but is there mucus in UC?" Gut 63, no. 2 (April 17, 2013): 216–17. http://dx.doi.org/10.1136/gutjnl-2013-304602.

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20

Nassar, Amin, Kent William Mouw, Edward D. Esplin, Shan Yang, Tom Callis, Pier Vitale Nuzzo, Nieves M. Chanza, Toni K. Choueiri, David J. Kwiatkowski, and Guru Sonpavde. "Germline alterations in urothelial carcinoma (UC) patients with family history of UC." Journal of Clinical Oncology 37, no. 7_suppl (March 1, 2019): 474. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.474.

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474 Background: UC is associated with germline alterations in a small minority of patients (pts). The prevalence of germline alterations in those with familial UC is unknown. We identified genomic alterations among familial UC pts to provide insights into pathogenesis and improve management. Methods: We analyzed deidentified data for UC pts with germline multigene panel testing (Invitae) who had a family history of UC, defined as a 1st-3rd degree relative with UC. Massively parallel sequencing used customized capture bait-sets to analyze exonic regions, flanking intronic sequences, and copy number variations (CNVs) for 1-126 genes. Pathogenic and likely pathogenic (P/LP) variants underwent orthogonal confirmation, per standard policy, including single nucleotide variants (SNVs)/small indels/CNVs. Patient characteristics were compared using the Fisher’s Exact and Wilcoxon-Rank Sum test. Results: 79 UC pts with a family history of UC were identified (67 bladder, 6 upper tract, 6 unknown). Six patients (8%) were excluded as the relation of the family member was unknown. 48/73 (66%) pts had first-degree relatives (fdr) with UC (4 upper tract, 39 bladder, 5 unknown) and 25 (34%) had second-degree (or higher) relatives (sdr) (2 upper tract, 22 bladder, 1 unknown). 56 germline alterations were found in 38 (52%) pts. 14 known pathogenic alterations occurred in 13 (18%) pts: SDHC (1), MITF (2), BRIP1 (1), BRCA2 (1), MSH2 (3), BRCA1 (1), CHEK2 (1), PTCH (1), MUTYH (2), BAP1 (1). 8/48 (17%) pts with fdr had pathogenic variants vs. 5/25 (20%) pts with sdr or more. There was no difference in the prevalence of pathogenic variants based on gender (p=0.37) or age (p=0.77). The limitations are modest sample size and differences in panels of genes. Conclusions: This is the first study to our knowledge to report germline alterations in UC pts with a family history of UC. Pathogenic germline alterations were seen in 18% of pts, which were enriched for DNA damage repair gene alterations, and could have important therapeutic implications. Further study of germline alterations using larger panels in pts with family history of UC may provide novel insights, since most pts did not have pathogenic alterations.

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21

Garzon, Ramiro, Catherine E. A. Heaphy, Chang Gong Liu, George A. Calin, and Carlo M. Croce. "Ultraconserved Genomic Regions (UCRs) Expression in Hematopoiesis." Blood 112, no. 11 (November 16, 2008): 2461. http://dx.doi.org/10.1182/blood.v112.11.2461.2461.

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Abstract UCRs are a subset of conserved sequences (100% between orthologous regions of human, rat and mouse genomes) located in both intra- and intergenic regions. There are 481 UCRs described and more than 50% of all the UCRs (256/481) has been classified as non exonic (with no evidence of coding protein), while the other 47% have been designated either exonic (overlap mRNAs of known genes), or possible exonic (with no clear evidence of overlap with protein coding genes) (Bejerano et al, Science 2004). Recently, our group reported that a subset of transcribed UCRs is aberrantly expressed in leukemia (Calin et al, Cancer Cell 2007). Because of the high degree of conservation, the UCRs are likely to be functional and may be involved in the phylogeny of mammals. Since hematopoiesis is regulated by signaling pathways and transcription factors that are highly conserved throughout phylogeny, we hypothesize that UCRs may be differentially expressed in hematopoietic tissues and may play a role in the regulation of this process. In this study we analyzed the UCRs expression in normal hematopoiesis by performing microarray analysis of hematopoietic precursors (HPCs) obtained by culturing human bone marrow (non-mobilized) CD34+ selected cells with different cytokine combinations for 2 weeks to stimulate differentiation to the erythrocyte (E), megakaryocyte (MK), monocyte (M) and granulocyte lineages (G). The following cytokine combinations were used: E (TPO/SCF/IL-3); G (G-CSF, GM-CSF, SCF, IL-3, IL-3); MK (TPO, SCF, IL-3) and M (M-CSF, GM-CSF, IL-6, IL-3 and SCF). Differentiation to the selected lineages was monitored every 3 days using morphology, special staining (benzidine) and flow cytometry analysis using appropriate lineage specific antibodies. Human bone marrow CD34+ and peripheral blood (PB) CD3+ (pan-T cells) and CD19+ (B-lymphocytes) selected cells were obtained from 3 different donors. Total RNA was obtained from the E and M cultures at days 7, 9, 11 and 14; G (days 10 and 14) and MK at day 14 and was hybridized in duplicate to the UCRs microarray chip (OSU version 4). After normalization of the array data with quantiles we analyzed the data using the BRB tools. Unsupervised analyses of the data revealed that samples segregated mainly in 6 main clusters corresponding to the M, E, G and Mk lineages, PB lymphocytes and CD34+ cells. Next we performed a series of two class analysis where we compared the UCRs expression of CD34+ cells vs. differentiated cells (E, G, MK, M, T and B-lymphocytes) one at a time (i.e. CD34+ cells vs. E). In table 1 we showed the top UCRs differentially expressed between in vitro differentiated HPCs/PB lymphocytes and CD34+ cells (+ or − sign reflects if the UCRs is in the sense (+) or antisense orientation (−). Table 1 Erythrocyte Megak Monocyte Granulocyte Pan T-Lym CD19+ Lym Up-regulated uc.283+ uc.285+ uc.132− uc.161+ uc.419− uc.469− uc.285+ uc.350+ uc.33+ uc.145− uc.145− uc.132− uc.10+ uc.73+ uc.420− uc.262− uc.382− uc.145− uc.188− uc.356− uc.269− uc.170− uc.170− uc.170− Down-regulated uc.43− uc.309+ uc.188− uc.160+ uc.356− uc.331+ uc.183− uc.43− uc.160+ uc.356− uc.477+ uc.183− These signatures were highly predictive since only few UCRs (mean 24) were able to predict the lineage of origin with no error (mean percentage of correct classification: 100%) after cross validation using multiples algorhytm (Class prediction within BRB). We validated the array results for uc.283+, uc.285+ and uc.161+ in a panel of differentiated CD34+ HPCs and CD34+ cells using qRT-PCR. In summary we have characterized the UCRs expression during hematopoietic differentiation of HSC and identified distinctive signatures associated with particular lineages. This research has the potential to identify novel regulators of hematopoiesis and may give insights into basic biology of gene expression and cell fate determination.

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22

Liwnicz, B. H., G. Archer, S. M. Soukup, and R. G. Liwnicz. "TWO NEW CONTINUOUS HUMAN GLIOMA-DERIVED CELL LINES, UC-11MG and UC-302MG." Journal of Neuropathology and Experimental Neurology 44, no. 3 (May 1985): 316. http://dx.doi.org/10.1097/00005072-198505000-00036.

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23

Monica, Ervin, Primayuni Dhia Hasanah, Arief Fadillah, Rara Aulia, Eko Sulistijono, and Satrio Wibowo. "Administration of Vitamin D3 Improves Hemoglobin Level by Regulating TNF-a and IL-6 in DSS-induced Colitis Mice." Indonesian Biomedical Journal 12, no. 2 (June 29, 2020): 130–5. http://dx.doi.org/10.18585/inabj.v12i2.1045.

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BACKGROUND: Anemia is frequently found in ulcerative colitis (UC) patients and assumed to be related to inflammatory process. Vitamin D3 (VD) is known to have anti-inflammatory and immunomodulatory effects. It also has the potential to be an alternative treatment of the inflammatory process that occurs at UC, however its mechanism has not been clearly established. This study aimed to assess the effect of VD on histopathology and hemoglobin levels in UC through its regulation in tumor necrosis factor (TNF)-α and interleukin (IL)-6.METHODS: Total samples of 24 mice were divided equally into Sham group, UC group, UC+VD group (given 3% dextran sodium sulfate (DSS) followed by VD), and VD+UC group (given VD followed by 3% DSS). Mouse Colitis Histology Index (MCHI) was used to measure histopathological changes. Immunohistochemical staining was used to observe expression of TNF-α and IL-6 in colon. Evaluation of anemia was determined by hemoglobin levels.RESULTS: Based on MCHI scores, significant epithelial damage was found in colon sample of UC group (8.25±3.05) compared to Sham (0.33±0.26), UC+VD (2.33±1.07), and VD+UC group (2.83±0.75) (p<0.05). Significant lower numbers of TNF-α were found in Sham (27.33±3.42), UC+VD (36.33±1.86), and VD+UC group (36.68±1.86) compared with UC group (44.66±4.87) (p<0.05). Significant less IL-6 expression was found in Sham (18.05±2.96), UC+VD (24.78±0.79), and VD+UC group (25.09±2.79) compared to UC group (38.85±3.51) (p<0.05). Differences in hemoglobin levels were significantly lower in UC group (11.85±0.97) compared to Sham (14.25±0.47), UC+VD (13.68±0.68), VD+UC group (13.52±1.07) (p<0.05).CONCLUSION: VD significantly reduced proinflammatory cytokines, increased mucosal repair, and improved hemoglobin levels.KEYWORDS: colitis, ulcerative, interleukin-6, tumor necrosis factor-alpha

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24

Kim, J., H. Kim, S. C. Park, J. K. Lee, D. R. Kang, S. Y. Kim, H. S. Kim, and H. M. Kim. "P109 Risk of cervical cancer in incident Ulcerative Colitis during the first 10 years after diagnosis: A nationwide population-based study." Journal of Crohn's and Colitis 16, Supplement_1 (January 1, 2022): i201—i202. http://dx.doi.org/10.1093/ecco-jcc/jjab232.237.

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Abstract Background Several studies suggested association between inflammatory bowel disease (IBD) and risk of cervical cancer in women. We investigated the risk of cervical cancer in patients with ulcerative colitis (UC) using the nationwide population-based claims data in South Korea. Methods We analysed the claims data of the Korean National Health Insurance (2006–2015). UC and cervical cancer were defined using International Classification of Diseases-10 codes and UC-specific prescription. Age- and sex-matched individuals without UC (control group) were randomly selected from the general population. Hazard ratios (HRs), adjusted for different covariates, were calculated using multivariate Cox proportional hazard regression. Results In total, 30,546 and 88,829 individuals with UC and without UC, respectively, were enrolled. Cervical cancer developed in 26 (0.21%) among UC patients, and 51 (0.14%) among control group, respectively. The standardized incidence ratio (SIR) of cervical cancer in the UC and non-UC groups were 2.04(95% confidence interval [CI], 1.33–2.98), and 1.35(95% CI, 1.00–1.77). The HR of cervical cancer in UC group, with reference to the non-UC group, was 1.56 (95% CI, 0.97–2.50). Further, UC groups were stratified according to age (HR=9.89, 1.62, 0.79 and 3.65 for 0–19, 20–39, 40–59, and ≥60 years, respectively). HR was significantly higher for early-onset UC (0–19 years) and late-onset UC (≥60 years). Among UC, age≥40, low socioeconomic status, rural residence, cerebral vascular disease are risk factors for cervical cancer. Conclusion UC patients had an increased risk of cervical cancer, especially with early-onset (0–19 years) and late-onset (>59 years). Since cervical cancer incidence is higher in UC patients than in the general population, UC patients should receive the human papillomavirus vaccine prophylactically.

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25

Wang, Ming-Hsi, Omar Y. Mousa, Jessica J. Friton, Laura E. Raffals, Jonathan A. Leighton, Shabana F. Pasha, Michael F. Picco, et al. "Unique Phenotypic Characteristics and Clinical Course in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis: A Multicenter US Experience." Inflammatory Bowel Diseases 26, no. 5 (October 18, 2019): 774–79. http://dx.doi.org/10.1093/ibd/izz209.

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Abstract Introduction Ulcerative colitis (UC) associated with primary sclerosing cholangitis (PSC) is a rare phenotype. We aimed to assess patients with UC-PSC or UC alone and describe differences in clinical and phenotypic characteristics, antitumor necrosis factor (TNF) therapy, and long-term clinical outcomes. Methods This retrospective multicenter cohort study included patients who received a diagnosis of UC from 1962 through 2015. We evaluated clinical factors associated with UC-PSC vs UC alone and assessed associations by using multivariable logistic regression models. Results Among 522 patients with UC, 56 (10.7%) had PSC. Compared with UC alone, patients with UC-PSC were younger (younger than 20 years) at diagnosis (odds ratios [OR], 2.35; adjusted P = 0.02) and had milder UC severity (adjusted P = 0.05), despite having pancolonic involvement (OR, 7.01; adjusted P < 0.001). In the biologics era (calendar year 2005 to 2015), patients with UC-PSC less commonly received anti-TNF therapy compared with patients with UC (OR, 0.38; adjusted P = 0.009), but their response rates were similar. Fewer patients with UC-PSC received corticosteroids (OR, 0.24; adjusted P = 0.005) or rectal 5-aminosalicyte acid (OR, 0.26; adjusted P < 0.001). Other differences were identified that were not statistically significant in a multivariable model: patients with UC-PSC more commonly were male, had lower rates of smoking, and had higher rates of colorectal cancer and colectomy. Discussion This study identified a unique phenotype of UC with concurrent PSC, which had different clinical behavior compared with UC only. These phenotypic characteristics can help identify high-risk patients with UC before PSC is diagnosed and guide different management and monitoring strategies.

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26

Chen, Dafan, Jing Ma, Shengzheng Luo, Lungen Lu, Xinjian Wan, and Qiwen Ben. "Effects of Appendectomy on the Onset and Course of Ulcerative Colitis in Chinese Patients." Gastroenterology Research and Practice 2018 (November 6, 2018): 1–6. http://dx.doi.org/10.1155/2018/2927891.

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Background. Previous epidemiological studies have suggested that appendectomy may be a protective factor against the development of ulcerative colitis (UC). However, the results of these studies were inconsistent, with rare studies in Chinese populations. Aim. This study examined the associations between appendectomy performed before UC diagnosis and the occurrence and clinical course of UC in Chinese patients. Methods. A case control study was conducted to compare the rate of appendectomy between UC patients and controls matched for age and sex at two Chinese hospitals. Clinical course of UC was compared between UC patients who underwent appendectomies before UC diagnosis and who did not. Results. 402 UC patients and 402 controls were included. The percentage of appendectomy performed before UC diagnosis in UC patients did not differ significantly from controls (2.74% vs 3.98%, P=0.442). Subgroup analysis on the basis of localization of UC patients did not find significant difference from controls. The extent of disease involvement in UC patients who underwent appendectomy was smaller than patients who did not (P=0.009). Appendectomy was found to be significantly related to the location of the disease independent of smoking status in multivariate analysis (P<0.001). Appendectomy did not influence severity of disease and need for immunosuppressive treatment or colectomy. Conclusion. We did not find a significant negative association between appendectomy and the UC occurrence in Chinese patients. Appendectomy performed before UC diagnosis may reduce the extent of UC involvement.

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27

Scanlon, Enya, Seamus J. Murphy, Richard D. Kennedy, and Jaine K. Blayney. "Defining an IBD-like subgroup in consensus molecular subgroups of colorectal cancer and transcriptomic biomarker development for at-risk patients." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e15142-e15142. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e15142.

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e15142 Background: Ulcerative colitis (UC), is a known risk-factor for colorectal cancer (CRC). 10% of UC-patients develop UC-specific CRC yet there are currently no biomarkers for early detection or understanding of drivers of disease. Unresolved inflammation is key in UC-CRC development, yet the aetiology is unclear. It is unknown if UC-CRC falls into a specific consensus molecular subgroup in the CMS classification (Guinney et al 2015). This bioinformatics approach aimed to identify patients at-risk of developing UC-CRC, whilst informing biological and clinical understanding of the disease. Methods: We used publicly available UC data and in-silico, cross platform, class label transfer (GECA) to determine mRNA similarity between UC/UC-CRC and sporadic CRC (sCRC) and to identify a UC-predominant CMS. Pathogenic mutations were identified for each CMS as well as gene set enrichment and survival analysis to determine UC-CRC behaviour comparative to sCRC. Transcriptional relationships were assessed via unsupervised and semi-supervised clustering by immune-signatures and scores to determine molecular patterns between phenotypes. We derived a gene list from UC data informed by clustering to stratify patients based on risk to UC-CRC progression. Results: UC-CRC featured predominantly in the NA group, with 3 attributed pathogenic mutations, an oxidative stress environment and neuroendocrine dysregulation. The subgroup had UC-like clinical features; younger age, distal tumour location and TP53 mutations along with the highest rate of cancer recurrence (~20%) and a unique cellular composition in CMS being highly immune and stromal. Importantly this immune signal was distinct from the interferon type signalling observed in CMS1 and was not associated with PD-L1 activation. Clustering revealed a loss of IFN-type gene expression in colon tissue as UC progressed to UC-CRC. Conclusions: The NA group was thought to be unclassifiable samples between CMS however, analysis shows UC-CRC enrichment with defined biological characteristics. We have identified novel biology that may inform the risk of developing UC-CRC and guide potential preventative and therapeutic approaches.

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28

Fairey, Adrian Stuart, Eila C. Skinner, Anne Schuckman, Gary Leiskovsky, Jie Cai, Gus Miranda, and Siamak Daneshmand. "The influence of variant histology on survival outcomes of radical cystectomy for bladder cancer." Journal of Clinical Oncology 30, no. 5_suppl (February 10, 2012): 278. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.278.

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278 Background: The role of variant histology bladder cancer as an independent prognostic factor for survival after radical cystectomy is poorly defined. Our aim was to examine the impact of variant histology on survival. Methods: A retrospective analysis of prospectively collected data from the University of Southern California Bladder Cancer Database was performed. Between 1971 and 2008, 2098 patients underwent radical cystectomy and extended pelvic lymph node dissection for primary bladder cancer. All surgical specimens underwent centralized pathologic review by dedicated genitourinary pathologists. Histologic type was categorized according to the WHO/ISUP 1998 classification as urothelial carcinoma (UC; n=1595), UC + variant (n=380), or non-urothelial carcinoma (Non-UC; n=123). The outcomes were overall survival (OS) and recurrence-free survival (RFS). The Kaplan-Meier method and Cox proportional regression models were used to analyze survival data. Results: The median follow-up duration was 12.8 years (range, 0 to 36.6 years). The predicted 5-year OS (61%, 53%, and 47%, Log rank p=0.005) and RFS (68%, 59%, and 58%, Log rank p=0.001) rates differed between patients with UC, UC + variant, and Non-UC histology. Multivariable analysis showed that Non-UC (but not UC + variant) histology was independently associated with OS (Non-UC versus UC: HR 1.26, 95% CI 1.01 to 1.57, p=0.040; UC + variant versus UC: HR 0.97, 95% CI 0.85 to 1.12, p=0.697) but not RFS (Non-UC versus UC: HR 1.14, 95% CI 0.83 to 1.56, p=0.411; UC + variant versus UC: HR 1.06, 95% CI 0.88 to 1.28, p=0.551). Conclusions: Non-UC histology was independently associated with poorer OS after radical cystectomy for bladder cancer. Clinical trials are needed to determine whether this high risk group will benefit from multimodal therapy.

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Murasugi, Shun, Ayumi Ito, Teppei Omori, Shinichi Nakamura, and Katsutoshi Tokushige. "Clinical Characterization of Ulcerative Colitis in Patients with Primary Sclerosing Cholangitis." Gastroenterology Research and Practice 2020 (November 7, 2020): 1–8. http://dx.doi.org/10.1155/2020/7969628.

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Objectives. The clinical/colonoscopic features of ulcerative colitis (UC) associated with primary sclerosing cholangitis (PSC), the prognostic impact of UC, and the utility of UC screening in PSC patients are unknown. We characterized UC associated with PSC and assessed UC’s impact on the prognosis of PSC and the importance of colonoscopic UC screening in PSC patients. Methods. We retrospectively analyzed the cases of 77 patients treated for PSC at a single center (April 2000–July 2019). We reviewed the clinical/colonoscopic profiles of the concurrent UC patients and compared the clinical profiles, survival, and primary causes of death between the patients with/without UC ( n = 35 / n = 42 ). The details of all patients’ colonoscopies were reviewed. Results. The concurrent UC group: 17 men, 18 women, diagnosed with PSC at the mean (SD) age of 36 (17) years; 21 patients (60%) had no UC symptoms. Colonoscopy revealed pancolitis in all patients, predominantly affecting the right-sided colon in 30 patients (86%). Lesions were scattered. Backwash ileitis ( n = 13 , 37%) and rectal sparing ( n = 18 , 51%) were observed. Most patients had mild UC; some had moderate or more severe UC (median Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score 2; range, 1–5). Ludwig’s stage determined by liver biopsy did not correlate with the Mayo endoscopic score for UC. The patients with UC were diagnosed with PSC at a significantly younger age than those without UC (mean (SD), 36 [17] years vs. 55 [19] years, p < 0.0001 ) and had a significantly higher 5-year survival rate (97.1% vs. 70.5%, p = 0.0028 ). UC was detected in 19 of 34 asymptomatic patients (56%) who underwent colonoscopy screening. Conclusions. Our cohort’s clinical/colonoscopic features of UC associated with PSC are more moderate or severe UC than previous cases. The coexistence of UC might affect the prognosis of PSC. In this regard, colonoscopy in PSC patients is an important examination for determining prognosis. There is also asymptomatic UC in patients with PSC. In this regard, screening for colonoscopy in PSC patients is essential. When a diagnosis of PSC is made, immediate colonoscopy is a priority with UC complications in mind.

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30

Toledo Mauriño, Joel J., Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Rafael Barreto-Zuñiga, Braulio Martínez Benítez, Julio Granados, and Jesus K. Yamamoto-Furusho. "TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis." Journal of Immunology Research 2020 (May 8, 2020): 1–11. http://dx.doi.org/10.1155/2020/2906845.

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Introduction. TRPVs are a group of receptors with a channel activity predominantly permeable to Ca2+. This subfamily is involved in the development of gastrointestinal diseases such as ulcerative colitis (UC). The aim of the study was to characterize the gene and protein expression of the TRPV subfamily in UC patients and controls. Methods. We determined by quantitative PCR the gene expression of TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6 in 45 UC patients (29 active UC and 16 remission UC) and 26 noninflamed controls. Protein expression was evaluated in 5 μm thick sections of formalin-fixed, paraffin-embedded tissue from 5 customized severe active UC patients and 5 control surgical specimens. Results. TRPV2 gene expression was increased in the control group compared with active UC and remission patients (P=0.002 and P=0.05, respectively). TRPV3 gene expression was significantly higher in controls than in active UC patients (P=0.002). The gene expression of TRPV4 was significantly higher in colonic tissue from patients with remission UC compared with active UC patients (P=0.05) and controls (P=0.005). TRPV5 had significantly higher mRNA levels in a control group compared with active UC patients (P=0.02). The gene expression of TRPV6 was significantly higher in the colonic tissue from patients with active UC compared with the control group (P=0.05). The protein expression of TRPV2 was upregulated in the mucosa and submucosa from the controls compared with the UC patients (P≤0.003). The protein expression of TRPV3 and TRPV4 was upregulated in all intestinal layers from the controls compared with the UC patients (P<0.001). TRPV5 was upregulated in the submucosa and serosa from the controls vs. UC patients (P<0.001). TRPV6 was upregulated in all intestinal layers from the UC patients vs. controls (P≤0.001). Conclusion. The TRPV subfamily clearly showed a differential expression in the UC patients compared with the controls, suggesting their role in the pathophysiology of UC.

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Shafiee, Nor Hamizah, Zahara Abdul Manaf, Norfilza M. Mokhtar, and Raja Affendi Raja Ali. "An assessment of dietary intake, food avoidance and food beliefs in patients with ulcerative colitis of different disease status." Intestinal Research 18, no. 4 (October 31, 2020): 447–58. http://dx.doi.org/10.5217/ir.2019.00042.

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Background/Aims: Ulcerative colitis (UC) is a chronic, relapsing and remitting inflammation of the gastrointestinal tract. Little is known about the link between dietary intake, food avoidance, and beliefs among UC patients of different disease severity. Therefore, this study aimed to assess the dietary intake, food avoidance, and beliefs among active and inactive UC patients.Methods: A cross-sectional study was conducted among UC patients from a tertiary medical center in Kuala Lumpur, Malaysia. Demographic, anthropometric, dietary intake, food avoidance and beliefs were assessed. Disease activity of UC patients was evaluated using the Powell Tuck Index. Results: UC patients were recruited (64.1% inactive UC and 35.9% active UC). As compared to inactive UC patients, active UC patients were likely to lose weight (75.0% vs. 0%), possess certain food beliefs (95.7% vs. 39.0%), and frequently practiced dietary avoidance (95.7% vs. 43.9%). The dietary intake among inactive UC patients was higher than active UC patients. However, neither of them met the standard nutrients recommendation for protein, calcium, iron, folate, zinc, vitamin D, vitamin B<sub>12</sub>, and vitamin E. Conclusions: Active UC patients had poorer dietary intake, were more prone to practicing food avoidance and exhibited certain food beliefs as compared to inactive UC patients. Both macro- and micronutrients intakes were inadequate regardless of patient’s disease status. These findings emphasized the importance for patients to be provided with the nutrition-related knowledge as part of strategies to avoid nutritional inadequacies.

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Iwatani, Sota, Akemi Shono, Makiko Yoshida, Keiji Yamana, Khin Kyae Mon Thwin, Jumpei Kuroda, Daisuke Kurokawa, et al. "Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation." Stem Cells International 2017 (2017): 1–16. http://dx.doi.org/10.1155/2017/8749751.

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Mesenchymal stem cells (MSCs) are a heterogeneous cell population that is isolated initially from the bone marrow (BM) and subsequently almost all tissues including umbilical cord (UC). UC-derived MSCs (UC-MSCs) have attracted an increasing attention as a source for cell therapy against various degenerative diseases due to their vigorous proliferation and differentiation. Although the cell proliferation and differentiation of BM-derived MSCs is known to decline with age, the functional difference between preterm and term UC-MSCs is poorly characterized. In the present study, we isolated UC-MSCs from 23 infants delivered at 22–40 weeks of gestation and analyzed their gene expression and cell proliferation. Microarray analysis revealed that global gene expression in preterm UC-MSCs was distinct from term UC-MSCs. WNT signaling impacts on a variety of tissue stem cell proliferation and differentiation, and its pathway genes were enriched in differentially expressed genes between preterm and term UC-MSCs. Cell proliferation of preterm UC-MSCs was significantly enhanced compared to term UC-MSCs and counteracted by WNT signaling inhibitor XAV939. Furthermore, WNT2B expression in UC-MSCs showed a significant negative correlation with gestational age (GA). These results suggest that WNT signaling is involved in the regulation of GA-dependent UC-MSC proliferation.

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Yamada, Shunsuke, Yuka Kanazawa, Noriko Nakamura, Kosuke Masutani, Motohiro Esaki, Takanari Kitazono, and Kazuhiko Tsuruya. "Ulcerative Colitis Presented as Fever and Bloody Diarrhea at Initiation of Dialysis in an Elderly Patient with End-Stage Kidney Disease." Case Reports in Medicine 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/725205.

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Ulcerative colitis (UC) is a chronic inflammatory bowel disorder that mainly affects the colon and rectum. Immunological derangements are associated with the pathogenesis of UC. Many patients with UC also have chronic kidney disease, associated with immunological disorders and/or pharmacotherapy for UC. Some patients with UC may develop end-stage renal disease (ESRD) and require renal replacement therapy. However, little is known clinically about ESRD patients who develop UC or about patients with UC who develop ESRD. This report describes an elderly patient with ESRD who presented with fever and bloody diarrhea and was finally diagnosed as UC (pancolitis type) at dialysis initiation. The patient was successfully treated with a series of immunosuppressive agents. This report highlights the importance of considering UC as a potential cause of bloody stool and fever in patients with ESRD.

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Kim, Youngsoo, Kihwan Moon, Young Lee, Seokhyeon Hong, and Soon-Hong Kwon. "Improving Upconversion Efficiency Based on Cross-Patterned Upconversion Material Slot Waveguides on a Silicon Layer." Nanomaterials 9, no. 4 (April 3, 2019): 520. http://dx.doi.org/10.3390/nano9040520.

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Upconversion (UC) materials can be used to harvest near-infrared (NIR) light and convert it into visible light. Although this improves optical device operating spectral range and efficiency, e.g., solar cells, typical UC material conversion efficiency is too low for practical devices. We propose a cross-patterned slot waveguide constructed from UC material embedded in a high index semiconductor layer to improve UC. Since the slot waveguide mode is induced in the low index UC slot, NIR absorption (~970 nm) increased 25-fold compared with film structures. Furthermore, the spontaneous emission enhancement rate at 660 nm increased 9.6-fold compared to the reference film due to resonance excited in the UC slot (Purcell effect). Thus, the proposed UC slot array structure improved UC efficiency 240-fold considering absorption and emission enhancements. This double resonance UC improvement can be applied to practical optical devices.

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Xia, Sheng-Long, Shi-Jie Ying, Qian-Ru Lin, Xiao-Qi Wang, Wei-Jun Hong, Zi-Jian Lin, Jia-Kai Luo, and Yi Jiang. "Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients." Gastroenterology Research and Practice 2019 (February 24, 2019): 1–10. http://dx.doi.org/10.1155/2019/4052168.

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Abnormalities of forkhead box P3 (FOXP3) are implicated in various autoimmune diseases. This study is aimed at investigating the association of ulcerative colitis (UC) with FOXP3 polymorphisms and its colonic expression in Chinese patients. Polymorphisms of rs3761548, rs2232365, rs2294021, and rs3761547 were examined in 472 UC patients and 525 healthy controls using the SNaPshot method. The colonic expression of FOXP3 mRNA and protein was assayed in inflammatory mucosa of 34 UC patients and normal mucosa of 36 patients with benign sigmoid polyps (normal controls) using real-time quantitative polymerase chain reaction and immunohistochemical analysis. All data were handled separately for females and males. As a result, the carrier frequencies with at least one variant allele of rs3761548, rs2232365, and rs229402 increased in female and male UC patients compared with healthy controls. Significant differences in these carrier frequencies were also observed between patients with mild and moderate UC and patients with severe UC. The expression of FOXP3 was higher in UC patients (both males and females), especially those with severe UC, than in normal controls. The expression of FOXP3 was downregulated in UC patients having at least one variant allele compared with UC patients having no variant allele of rs3761548, rs2232365, and rs2294021. Male gender (β=−0.341), rs2294021 variation (β=−0.503), and severe UC (β=0.361) were independently related to the mRNA expression of FOXP3 in UC patients. Together, our findings indicated that FOXP3 (rs3761548, rs2232365, and rs2294021) variations increased the risk of UC and were associated with the lower colonic expression of FOXP3 in UC patients.

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Zhou, Qing, Zhao-Feng Shen, Ben-sheng Wu, Cheng-biao Xu, Zhong-qi He, Tuo Chen, Hong-tao Shang, et al. "Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis." Gastroenterology Research and Practice 2019 (November 3, 2019): 1–11. http://dx.doi.org/10.1155/2019/5363261.

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Background. Ulcerative colitis (UC) patients have an increased risk for the development of colorectal cancer (CRC). Our aim was to assess the risk of CRC in UC patients compared with disease extent, disease duration, and geographic variation. Methods. In this systematic review and meta-analysis, we searched PubMed, scientific meetings, and the bibliographies of identified articles, with English language restrictions for studies published from 1988 to 2018, and assessed the risk of CRC in UC patients. Patients with Crohn’s disease, family history of CRC, and colorectal adenomatous polyp (CAP) were excluded from this research. The study was registered with PROSPERO, number CRD42018102213. Findings. We included 58 studies that included 267566 UC patients. Extensive UC and left-sided UC had a higher risk of CRC than proctitis UC. Geography also played a role in UC-associated CRC development. The time of malignant transformation in Asian UC patients started after 10-20 years of this disease duration. North American UC-associated CRC patients significantly increased in more than 30 years of this disease duration. Conclusion. In a systematic review of the literature, we found that disease extent, disease duration, and geography were strong, independent risk factors in UC-associated CRC development.

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Huynh Dr, H., H. Ma, D. Isaac, K. Novak, P. Almeida, J. Kim, A. Kuc, M. Carroll, and E. Wine. "P177 Validation of UC Intestinal Ultrasound (UC-IUS) Index for children with Ulcerative Colitis." Journal of Crohn's and Colitis 16, Supplement_1 (January 1, 2022): i245. http://dx.doi.org/10.1093/ecco-jcc/jjab232.305.

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Abstract Background Transabdominal bowel ultrasound (TABUS) is an ideal tool to assess transmural inflammation in children with Ulcerative Colitis (UC). The UC intestinal US (UC-IUS) Index was developed and validated using endoscopy with strong correlation between UC-IUS Index and Mayo subscore (ρ 0.830; p<0.001). Our aim was to determine how bowel wall thickness (BWT) and UC-IUS Index performed in children at diagnosis in comparison to endoscopy using the Mayo score. Methods Subjects (0–18 years old) with suspected inflammatory bowel disease (IBD) were prospectively enrolled. Baseline TABUS (excluding rectum due to poorly seen) done prior to endoscopy. Pediatric Ulcerative Colitis disease Activity Index (PUCAI) and Mayo were calculated, albumin, C-reactive protein (CRP) and fecal calprotectin (FCP) collected. The UC-IUS Index was calculated for each segment – sigmoid (SC), descending (DC), transverse (TC) and ascending (AC) [bowel wall thickness (BWT) (mm): > 2 =1, >3 =2 and >4 =3; doppler: spots=1 and stretches =2, abnormal haustrations = 1 and fat wrapping =1]. Spearman’s rank (rho) and Pearson’s correlation (r) assess for a correlation. Receiver operating characteristic [ROC] analysis performed for BWT to determine sensitivity and specificity of BWT cut-offs in the UC-IUS. Results Of the 75 subjects recruited for suspected IBD, 26 had UC with mean age 15 years (SD 3.33) and 5 had normal US. Twenty three have extensive pancolitis. Mean PUCAI score: 60 (SD 23.28), CRP 22.62 (SD 39.5) mg/l, albumin 35.6 (SD 6.96) g/l and fecal calprotectin of 2223 (SD 1757) mg/kg. ROC curves generated using a total of 122 colonic segments. BWT of 2 mm discriminates between active and inactive:Mayo 0 and Mayo1-3 [sensitivity 84.9%; specificity 86.2%; an area under the curve [AUC] 0.900]; a cut-off of 3mm discriminates between Mayo 1 from Mayo 2–3 [sensitivity of 61.3%; specificity 90.5%; AUC 0.858]; a cut of 4mm discriminates Mayo 3 (sensitivity 64.7%; specificity 85.7 %; AUC 0.876). BWT and UC-IUS scores of all colonic segments correlated highly positively with the Mayo score of corresponding segments (rho=0.684, r=0.660, p<0.001) and (rho=0.750, r=0.722, P<0.001) respectively. The UC-IUS Index correlates poorly with CRP, ESR, and Fecal Calprotectin - r = 0.262, 0.346 and 0.100 respectively; p>0.05. Conclusion BWT and UC-IUS Index correlated highly positively with the Mayo subscore in children with UC. UC-IUS has a better correlation than BWT. BWT cut-off of 2mm discriminate between normal and mild Mayo is optimal. Cut-offs of 3 mm and 4 mm for moderate and severe Mayo may be too high in children with lower sensitivity. A larger cohort of children with UC will need to be studied to determine optimal BWT cut-off for moderate and severe disease.

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38

Byron, Janet. "UC Berkeley launches landmark study." California Agriculture 53, no. 5 (September 1999): 5. http://dx.doi.org/10.3733/ca.v053n05p5.

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Schaller, C. W., L. F. Jackson, and L. Prato. "Registration of ‘UC 337’ Barley." Crop Science 30, no. 5 (1990): 1154. http://dx.doi.org/10.2135/cropsci1990.0011183x003000050042x.

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Schaller, C. W., L. F. Jackson, M. J. Smith, and L. Prato. "Registration of ‘UC 476’ Barley." Crop Science 30, no. 5 (1990): 1154. http://dx.doi.org/10.2135/cropsci1990.0011183x003000050043x.

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Schaller, C. W., L. F. Jackson, and L. Prato. "Registration of ‘UC 603’ Barley." Crop Science 30, no. 5 (1990): 1154. http://dx.doi.org/10.2135/cropsci1990.0011183x003000050044x.

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Humiston, Glenda. "UC ANR: The original incubator." California Agriculture 69, no. 4 (October 2015): 206–7. http://dx.doi.org/10.3733/ca.v069n04p206.

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43

Stronach, David, and Stephen Lumsden. "UC Berkeley's Excavations at Nineveh." Biblical Archaeologist 55, no. 4 (December 1992): 227–33. http://dx.doi.org/10.2307/3210319.

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44

Broidy, Ellen. "UC-Irvine’s Main Library reopens." College & Research Libraries News 58, no. 3 (March 1, 1997): 147. http://dx.doi.org/10.5860/crln.58.3.147.

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WILSON, ELIZABETH. "Genentech, UC end patent standoff." Chemical & Engineering News 77, no. 48 (November 29, 1999): 12. http://dx.doi.org/10.1021/cen-v077n048.p012.

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Gallagher, L. W., L. F. Jackson, R. W. Matchett, Y. P. Puri, and H. E. Vogt. "Registration of ‘UC 937’ Barley." Crop Science 42, no. 4 (July 2002): 1374. http://dx.doi.org/10.2135/cropsci2002.1374.

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Gallagher, L. W., L. F. Jackson, R. W. Matchett, Y. P. Puri, and H. E. Vogt. "Registration of ‘UC 960’ Barley." Crop Science 42, no. 4 (July 2002): 1374–75. http://dx.doi.org/10.2135/cropsci2002.1374a.

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Gallagher, L. W., L. F. Jackson, R. W. Matchett, Y. P. Puri, and H. E. Vogt. "Registration of ‘UC 933’ Barley." Crop Science 43, no. 1 (2003): 437. http://dx.doi.org/10.2135/cropsci2003.0437.

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Gallagher, L. W., L. F. Jackson, H. E. Vogt, and Y. P. Puri. "Registration of ‘UC 969’ Barley." Crop Science 43, no. 1 (2003): 438. http://dx.doi.org/10.2135/cropsci2003.0438.

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Gallagher, L. W., L. F. Jackson, R. W. Matchett, Y. P. Puri, and H. E. Vogt. "Registration of ‘UC 933’ Barley." Crop Science 43, no. 1 (2003): 437. http://dx.doi.org/10.2135/cropsci2003.4370.

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