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Journal articles on the topic 'Ubende'

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Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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1

Boven, A. "Timing of exhumation of a high-pressure mafic granulite terrane of the Paleoproterozoic Ubende belt (West Tanzania)." Precambrian Research 93, no. 1 (January 1999): 119–37. http://dx.doi.org/10.1016/s0301-9268(98)00101-6.

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2

Pasupala, Nagesh, Marie E. Morrow, Lauren T. Que, Barbara A. Malynn, Averil Ma, and Cynthia Wolberger. "OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination." Journal of Biological Chemistry 293, no. 47 (October 3, 2018): 18285–95. http://dx.doi.org/10.1074/jbc.ra118.004677.

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OTUB1 is a deubiquitinating enzyme that cleaves Lys-48–linked polyubiquitin chains and also regulates ubiquitin signaling through a unique, noncatalytic mechanism. OTUB1 binds to a subset of E2 ubiquitin-conjugating enzymes and inhibits their activity by trapping the E2∼ubiquitin thioester and preventing ubiquitin transfer. The same set of E2s stimulate the deubiquitinating activity of OTUB1 when the E2 is not charged with ubiquitin. Previous studies have shown that, in cells, OTUB1 binds to E2-conjugating enzymes of the UBE2D (UBCH5) and UBE2E families, as well as to UBE2N (UBC13). Cellular roles have been identified for the interaction of OTUB1 with UBE2N and members of the UBE2D family, but not for interactions with UBE2E E2 enzymes. We report here a novel role for OTUB1–E2 interactions in modulating E2 protein ubiquitination. We observe that Otub1−/− knockout mice exhibit late-stage embryonic lethality. We find that OTUB1 depletion dramatically destabilizes the E2-conjugating enzyme UBE2E1 (UBCH6) in both mouse and human OTUB1 knockout cell lines. Of note, this effect is independent of the catalytic activity of OTUB1, but depends on its ability to bind to UBE2E1. We show that OTUB1 suppresses UBE2E1 autoubiquitination in vitro and in cells, thereby preventing UBE2E1 from being targeted to the proteasome for degradation. Taken together, we provide evidence that OTUB1 rescues UBE2E1 from degradation in vivo.

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3

Bhardwaj, Abhishek, Robert S. Banh, Wei Zhang, Sachdev S. Sidhu, and Benjamin G. Neel. "MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation." Life Science Alliance 5, no. 5 (February 8, 2022): e202000807. http://dx.doi.org/10.26508/lsa.202000807.

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Single-nucleotide polymorphisms (SNPs) in RNF213, which encodes a 591-kD protein with AAA+ ATPase and RING E3 domains, are associated with a rare, autosomal dominant cerebrovascular disorder, moyamoya disease (MMD). MMD-associated SNPs primarily localize to the C-terminal region of RNF213, and some affect conserved residues in the RING domain. Although the autosomal dominant inheritance of MMD could most easily explained by RNF213 gain-of-function, the type of ubiquitylation catalyzed by RNF213 and the effects of MMD-associated SNPs on its E3 ligase activity have remained unclear. We found that RNF213 uses the E2-conjugating enzymes UBE2D2 and UBE2L3 to catalyze distinct ubiquitylation events. RNF213-UBED2 catalyzes K6 and, to a lesser extent, K48-dependent poly-ubiquitylation in vitro, whereas RNF213-UBE2L3 catalyzes K6-, K11-, and K48-dependent poly-ubiquitylation events. MMD-associated SNPs encode proteins with decreased E3 activity, and the most frequent MMD allele, RNF213R4810K, is a dominant-negative mutant that decreases ubiquitylation globally. By contrast, MMD-associated RNF213 SNPs do not affect ATPase activity. Our results suggest that decreased RNF213 E3 ligase activity is central to MMD pathogenesis.

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4

Hou, Liyan, Yingbo Li, Ying Wang, Dongqiang Xu, Hailing Cui, Xiaoyan Xu, Ying Cong, and Chengyong Yu. "UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma." Disease Markers 2018 (October 21, 2018): 1–8. http://dx.doi.org/10.1155/2018/4108919.

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In this study, we investigated the potential prognostic value of ubiquitin-conjugating enzyme E2D1 (UBE2D1) RNA expression in different histological subtypes of non-small-cell lung cancer (NSCLC). A retrospective study was performed by using molecular, clinicopathological, and survival data in the Cancer Genome Atlas (TCGA)—Lung Cancer. Results showed that both lung adenocarcinoma (LUAD) (N=514) and lung squamous cell carcinoma (LUSC) (N=502) tissues had significantly elevated UBE2D1 RNA expression compared to the normal tissues (p<0.001 and p=0.036, respectively). UBE2D1 RNA expression was significantly higher in LUAD than in LUSC tissues. Increased UBE2D1 RNA expression was independently associated with shorter OS (HR: 1.359, 95% CI: 1.031–1.791, p=0.029) and RFS (HR: 1.842, 95% CI: 1.353–2.508, p<0.001) in LUAD patients, but not in LUSC patients. DNA amplification was common in LUAD patients (88/551, 16.0%) and was associated with significantly upregulated UBE2D1 RNA expression. Based on these findings, we infer that UBE2D1 RNA expression might only serve as an independent prognostic indicator of unfavorable OS and RFS in LUAD, but not in LUSC.

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5

Roman-Trufero, Monica, Constance M. Ito, Conrado Pedebos, Indiana Magdalou, Yi-Fang Wang, Mohammad M. Karimi, Benjamin Moyon, et al. "Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3." Molecular Biology and Evolution 37, no. 7 (March 12, 2020): 1986–2001. http://dx.doi.org/10.1093/molbev/msaa060.

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Abstract Genetic variation in the enzymes that catalyze posttranslational modification of proteins is a potentially important source of phenotypic variation during evolution. Ubiquitination is one such modification that affects turnover of virtually all of the proteins in the cell in addition to roles in signaling and epigenetic regulation. UBE2D3 is a promiscuous E2 enzyme, which acts as an ubiquitin donor for E3 ligases that catalyze ubiquitination of developmentally important proteins. We have used protein sequence comparison of UBE2D3 orthologs to identify a position in the C-terminal α-helical region of UBE2D3 that is occupied by a conserved serine in amniotes and by alanine in anamniote vertebrate and invertebrate lineages. Acquisition of the serine (S138) in the common ancestor to modern amniotes created a phosphorylation site for Aurora B. Phosphorylation of S138 disrupts the structure of UBE2D3 and reduces the level of the protein in mouse embryonic stem cells (ESCs). Substitution of S138 with the anamniote alanine (S138A) increases the level of UBE2D3 in ESCs as well as being a gain of function early embryonic lethal mutation in mice. When mutant S138A ESCs were differentiated into extraembryonic primitive endoderm, levels of the PDGFRα and FGFR1 receptor tyrosine kinases were reduced and primitive endoderm differentiation was compromised. Proximity ligation analysis showed increased interaction between UBE2D3 and the E3 ligase CBL and between CBL and the receptor tyrosine kinases. Our results identify a sequence change that altered the ubiquitination landscape at the base of the amniote lineage with potential effects on amniote biology and evolution.

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6

Koutrika, Georgia, Qian Lin, and Jerry Liu. "User analytics with UbeOne." Proceedings of the VLDB Endowment 6, no. 12 (August 28, 2013): 1382–85. http://dx.doi.org/10.14778/2536274.2536321.

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7

Khan, Muhammad Irfan-ur-Rehman, Fernanda Caminha Faustino Dias, Isabelle Dufort, Vikram Misra, Marc-Andre Sirard, and Jaswant Singh. "Stable reference genes in granulosa cells of bovine dominant follicles during follicular growth, FSH stimulation and maternal aging." Reproduction, Fertility and Development 28, no. 6 (2016): 795. http://dx.doi.org/10.1071/rd14089.

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The aim of the present study was to determine a set of reference genes in granulosa cells of dominant follicles that are suitable for relative gene expression analyses during maternal and follicular aging. Granulosa cells of growing and preovulatory dominant follicles were collected from aged and young cows (maternal aging study) and from FSH-stimulated follicles developing under different durations of FSH treatment (follicular aging study). The mRNA levels of the two commonly used reference genes (GAPDH, ACTB) and four novel genes (UBE2D2, EIF2B2, SF3A1, RNF20) were analysed using cycle threshold values. Results revealed that mRNA levels of GAPDH, ACTB, EIF2B2, RNF20, SF3A1 and UBE2D2 were similar (P > 0.05) between dominant follicle type, age and among follicles obtained after FSH-stimulation, but differed (P = 0.005) due to mRNA processing (i.e. with versus without amplification). The stability of reference genes was analysed using GeNorm, DeltaCT and NormFinder programs and comprehensive ranking order was determined using RefFinder. The mRNA levels of GAPDH and ACTB were less stable than those of UBE2D2 and EIF2B2. The geometric mean of multiple genes (UBE2D2, EIF2B2, GAPDH and SF3A1) is a more appropriate reference control than the use of a single reference gene to compare relative gene expression among dominant and FSH-stimulated follicles during maternal and/or follicular aging studies.

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8

Talât, HALMAN. "Ubeyd-i Zâkânî." Türkoloji Dergisi 18, no. 1 (2011): 161–75. http://dx.doi.org/10.1501/trkol_0000000208.

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9

Hattori, Hidenori, Xueqing Zhang, Yonghui Jia, Kulandayan K. Subramanian, Hakryul Jo, Fabien Loison, Peter E. Newburger, and Hongbo R. Luo. "RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells." Blood 110, no. 2 (July 15, 2007): 640–50. http://dx.doi.org/10.1182/blood-2006-11-059048.

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Abstract All-trans retinoic acid (ATRA) has been widely used in differentiation therapy for acute promyelocytic leukemia (APL). ATRA binds to retinoic acid receptor (RAR) and triggers the formation of the transcription coactivator complex, which leads to changes in gene expression, APL cell-cycle arrest and differentiation, and clinical remission. The mechanisms responsible for ATRA's beneficial effects are still ill-defined. Here, we conducted a large-scale, unbiased short hairpin RNA (shRNA) screen aiming to identify mediators of ATRA-induced differentiation and growth arrest of APL cells. Twenty-six proteins were identified. They cover a wide range of cellular functions, including gene expression, intracellular signaling, cell death control, stress responses, and metabolic regulation, indicating the complexity of ATRA-induced cell growth control and differentiation in APL. One of these proteins, the ubiquitin-conjugating enzyme UBE2D3, is up-regulated in ATRA-treated acute promyelocytic NB4 cells. UBE2D3 is physically associated with cyclin D1 and mediates ATRA-induced cyclin D1 degradation. Knocking down UBE2D3 by RNA interference (RNAi) leads to blockage of ATRA-induced cyclin D1 degradation and cell-cycle arrest. Thus, our results highlight the involvement of the ubiquitin-mediated proteolysis pathway in ATRA-induced cell-cycle arrest and provide a novel strategy for modulating ATRA-elicited cellular effects.

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10

Halilović, Muamer. "Satire and social criticism in Ubayd Zakani's works." Kom : casopis za religijske nauke 9, no. 1 (2020): 1–26. http://dx.doi.org/10.5937/kom2001001h.

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11

Sievers, Quinlan L., Jessica A. Gasser, Glenn S. Cowley, Eric S. Fischer, and Benjamin L. Ebert. "Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity." Blood 132, no. 12 (September 20, 2018): 1293–303. http://dx.doi.org/10.1182/blood-2018-01-821769.

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Key Points Genome-scale CRISPR knockout screen identifies cullin-RING ligase regulators as top mediators of lenalidomide resistance. The E2 ubiquitin-conjugating enzymes, UBE2D3 and UBE2G1, play distinct roles in lenalidomide-induced substrate ubiquitination by CRL4CRBN.

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12

Jading, Abadi, Paulus Payung, and Reniana Reniana. "ansys fluent; CFD; PCRD; simulation; sago starch." Jurnal Ilmiah Rekayasa Pertanian dan Biosistem 10, no. 1 (March 24, 2022): 1–13. http://dx.doi.org/10.29303/jrpb.v10i1.279.

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The mini-scale pneumatic conveying ring dryer (PCRD) type sago starch dryer with a capacity of 80 kg / day has been applied to the processing of sago starch to produce dry sago starch. To increase the production capacity of the PCRD dryer, a recirculation pipe was modified. The modified pipe section is the venturi pipe diameter and the upriser vertical pipe increased. The diameter of the vertical upriser pipe is 2.5 times larger than that of the ubend pipe and the downcomer vertical pipe so that a buffer is formed. In addition, the difference in the diameter of the recirculation pipe can increase the residence time of the material. The purpose of this study was to simulate using ansys fluent to determine the temperature profile, air flow velocity, and pressure in the pneumatic conveying ring dryer (PCRD) type sago starch dryer pipe with a capacity of 1 ton per day. Simulations were carried out using the Computational Fluid Dynamics (CFD) technique using ansys fluent software package. The simulation results show that the temperature along the pipe has decreased by about 2oC at various variations of the input air velocity and variations in the outlet at the boundary conditions. Likewise, the air velocity at the end of the outlet pipe (vertical downcomer pipe) increases due to the difference in diameter with the inlet pipe. The pressure on the vertical upriser pipe is higher than the pressure on the ubend pipe and downcomer vertical pipe. The simulation results show that the recirculation pipe design is very well used so that it can be continued for the manufacture of PCRD-type sago starch dryer on a scale of 1 ton per day.

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13

Masso, Anu, Martha Chukwu, and Stefano Calzati. "(Non)negotiable spaces of algorithmic governance: Perceptions on the Ubenwa health app as a ‘relocated’ solution." New Media & Society 24, no. 4 (April 2022): 845–65. http://dx.doi.org/10.1177/14614448221079027.

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This study explores relocated algorithmic governance through a qualitative study of the Ubenwa health app. The Ubenwa, which was developed in Canada based on a dataset of babies from Mexico, is currently being implemented in Nigeria to detect birth asphyxia. The app serves as an ideal case for examining the socio-cultural negotiations involved in re-contextualising algorithmic technology. We conducted in-depth interviews with parents, medical practitioners and data experts in Nigeria; the interviews reveal individuals’ perceptions about algorithmic governance and self-determination. In particular, our study presents people’s insights about (1) relocated algorithms as socially dynamic ‘contextual settings’, (2) the (non)negotiable spaces that these algorithmic solutions potentially create and (3) the general implications of re-contextualising algorithmic governance. This article illustrates that relocated algorithmic solutions are perceived as ‘cosmopolitan data localisms’ that extend the spatial scales and multiply localities rather than as ‘data glocalisation’ or the indigenisation of globally distributed technology.

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14

Lee, Sang-Ok, Chong-Kil Lee, Kyoung-Seok Ryu, and Seung-Wook Chi. "The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction." Acta Crystallographica Section F Structural Biology Communications 76, no. 1 (January 1, 2020): 1–7. http://dx.doi.org/10.1107/s2053230x19015395.

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Mitochondrial E3 ubiquitin ligase 1 (MUL1) is located in the mitochondrial outer membrane and regulates various biological processes, including apoptosis, cell growth, mitophagy and mitochondrial dynamics. The C-terminal region of MUL1 faces the cytoplasm and contains the RING domain (MUL1-RING) where the Ub~E2 thioester binds. Unlike most RING-type E3 enzymes, MUL1-RING alone does not have an additional region that recruits a substrate protein, yet is still able to ubiquitylate the substrate, the p53 protein. Nevertheless, the exact mechanism of the ubiquitylation of p53 by MUL1-RING has not yet been elucidated. In order to understand this novel ubiquitylation mechanism, it is necessary to determine the three-dimensional structures of MUL1-RING and of its complex with the cognate E2 enzyme. Here, Ube2D2 was validated as a functional E2 enzyme for the ubiquitylation of the p53 transactivation domain (p53-TAD) by MUL1-RING, and purification and crystallization processes for MUL1-RING and the MUL1-RING–Ube2D2 complex are reported.

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15

Brito, José Renaldi F., and Ronaldo de Oliveira Sales. "Health of the ubere. A revision." Revista Brasileira de Higiene e Sanidade Animal 1, no. 1 (2007): 67–87. http://dx.doi.org/10.5935/1981-2965.20070005.

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16

Reinold, E., U. Hatter, and H. Hepp. "Uberden Versuch, wissenschaftliche Tagungen zu qualifizieren und zu quantifizieren." Gynäkologisch-geburtshilfliche Rundschau 36, no. 2 (1996): 61–62. http://dx.doi.org/10.1159/000272620.

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17

ÖLMEZ, Sadi. "The Formation, Systematics, and Differences of the Ibāḍiyya." Eskiyeni, no. 47 (September 20, 2022): 639–62. http://dx.doi.org/10.37697/eskiyeni.1124082.

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Öz Teşekkülü hicrî I. asra denk gelen İbâziyye mezhebi fıkhî bir mezhep vasfından ziyade daha çok siyasi bir fırka olarak şöhret bulmuştur. Böyle bir anlaşılmaya maruz kalmasının altında selef olarak kabul ettikleri bazı şahsiyetlerin Haricîlerle olan iltisakları yatmaktadır. Bu durum İbâziyye mezhebinin fıkhî bir mezhep olarak bilinmesinin önüne geçmiştir. Bundan ötürü İbâziyye mezhebi daha çok mezheplerler tarihi ve itikâdî görüşlerinden ötürü de kelam alanında çalışılmıştır. Bu yönelim de mezhebin fıkhî yönünün ihmal edilmesine sebep olmuştur. Oysa ki İbâziyye mezhebi zengin fıkhî müktesebatı ve literatürüyle müstakil bir ameli mezheptir. Hatta İbâzîlere göre kendi mezhepleri kronolojik olarak teşekkül eden ilk fikhî mezheptir. İbâziyye mezhebi Abdullah b. İbâz’a nispet olunmakla birlikte İbâziler Câbir b. Zeyd’i müessis olarak kabul ederler. İbâzîler hicrî 3. asrın sonralarına kadar kendilerini İbâzî olarak isimlendirmekten kaçınmışlardır. Çünkü İbâzîler fıkhî mezheplerin, kurucularına nispet edilmesini gerektiğini, mezhep kurucularının da Cabir b. Zeyd olduğunu söylerler. Mezheplerinin Abdullah b. İbâz’a nispet edilmesinin siyasi saikler nedeniyle olduğunu ısrarla vurgularlar. Bundan ötürü İbâzîler mezheplerinin müessisi olarak Câbir. b. Zeyd’i görürler. Câbir tâbiî alimlerinden olup Basra müftüsü olmasıyla da şöhret bulmuştur. İbâziyye mezhebinin Câbir’den sonra en önemli ismi olarak kabul edilen Ebû Ubeyde Muslim b. Ebî Kerime mezhebin teşekkülünde ve sistemleşmesinde çok önemli bir yere sahiptir. Ebû Ubeyde Gerek Emevîler gerekse de Abbâsîler döneminde İbâzîlere yönelik baskılara rağmen mezhebi bir arada tutarak Basra dışına özellikle de Kuzey Afrika’da yayılmasını sağlamıştır. İbâziyye mezhebinin hicrî 2. asrın ikinci çeyreğinden itibaren farklı coğrafyalara taşınması bu mezhebin sistemleşmesi açısından önemli bir merhale olmuştur. Ayrıca İbâziyye mezhebinin Basra dışındaki bölgelere yayılması İbâzî fıkıhla ilgili tedvinlerin artmasını sağlamıştır. İbâzî fıkhının en önemli eserleri arasında ilk sıralarda olan Ebû Ğânım el-Horasâni’ye ait olan el-Müdevvetü’l-Kübrâ bu dönemin mahsulüdür. İbâziyye mezhebi sünnî mezheplerin fıkhî meselelerde başvurdukları istinbât ve istidlâl yönteminden farklı bir yöntem kullanmamıştır. Kur’an, Sünnet, İcmâ, Kıyas ve diğer İstidlâl yöntemleri İbâzî fakihlerce de başvurulan yöntemler olmuştur. Dolayısıyla İbâzîlerin kullanmış olduğu usûl yöntemlerinin diğer mezheplerin usûl yöntemiyle bire bir aynı olmasa da bir birine çok yakın olduğunu söyleyebiliriz. İbâzîlerin istidlali deliller kısmında diğer mezheplerden farklılaşması ilham konusunda olmuştur. İbâzilerde tartışmalı olmakla birlikte ilham istidlali delillerden biri olarak zikredilmiştir. Bu çalışmamızda mezhebin teşekkülü esnasında Haricîlerle olan bağlantısı, mezhebin ortaya çıkışı, fıkhı ve usülüne değineceğiz.

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18

Wang, Xin, Lan-tao Wang, and Bin Yu. "UBE2D1 and COX7C as Potential Biomarkers of Diabetes-Related Sepsis." BioMed Research International 2022 (April 11, 2022): 1–14. http://dx.doi.org/10.1155/2022/9463717.

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Patients with diabetes are physiologically frail and more likely to suffer from infections and even life-threatening sepsis. This study aimed to identify and verify potential biomarkers of diabetes-related sepsis (DRS). Datasets GSE7014, GSE57065, and GSE95233 from the Gene Expression Omnibus were used to explore diabetes- and sepsis-related differentially expressed genes (DEGs). Gene set enrichment analysis (GSEA) and functional analyses were performed to explore potential functions and pathways associated with sepsis and diabetes. Weighted gene co-expression network analysis (WGCNA) was performed to identify diabetes- and sepsis-related modules. Functional enrichment analysis was performed to determine the characteristics and pathways of key modules. Intersecting DEGs that were also present in key modules were considered as common DEGs. Protein-protein interaction (PPI) network and key genes were analyzed to screen hub genes involved in DRS development. A mouse C57 BL/6J-DRS model and a neural network prediction model were constructed to verify the relationship between hub genes and DRS. In total, 7457 diabetes-related DEGs and 2606 sepsis-related DEGs were identified. GSEA indicated that gene datasets associated with diabetes and sepsis were mainly enriched in metabolic processes linked to inflammatory responses and reactive oxygen species, respectively. WGCNA indicated that grey60 and brown modules were diabetes- and sepsis-related key modules, respectively. Functional analysis showed that grey60 module genes were mainly enriched in cell morphogenesis, heart development, and the PI3K-Akt signaling pathway, whereas genes from the brown module were mainly enriched in organelle inner membrane, mitochondrion organization, and oxidative phosphorylation. UBE2D1, IDH1, DLD, ATP5C1, COX6C, and COX7C were identified as hub genes in the PPI network. Animal DRS and neural network prediction models indicated that the expression levels of UBE2D1 and COX7C in DRS models and samples were higher than control mice. UBE2D1 and COX7C were identified as potential biomarkers of DRS. These findings may help develop treatment strategies for DRS.

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Nnyigide, Nkoli Mercy. "Ọnọdụ ilu igbo n’iduuazị na abụ tony ubesie a họọrọ." OGIRISI: a New Journal of African Studies 12, no. 1 (July 21, 2016): 202. http://dx.doi.org/10.4314/og.v12is1.13.

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20

Niu, Yufei, Zhen Shen, and Haoyang Li. "Unilateral Biportal Endoscopic Discectomy versus Microendoscopic Discectomy for the Treatment of Lumbar Spinal Stenosis: A Systematic Review and Meta-Analysis." Computational and Mathematical Methods in Medicine 2022 (September 21, 2022): 1–11. http://dx.doi.org/10.1155/2022/7667463.

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Objective. In minimally invasive spinal surgery, the treatment of lumbar spinal stenosis with microendoscopic discectomy (MED) or unilateral biportal endoscopic discectomy (UBED) shows effective results, but which is more effective is controversial. Our study aimed to evaluate the efficacy and safety of UBED versus MED in the treatment of lumbar spinal stenosis by a systematic review and meta-analysis, so as to provide reference for the promotion of UBED in clinical practice. Methods. The multiple databases like PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Databases, Chinese BioMedical Database, and Wanfang Database were used to search for the relevant studies. Review Manager 5.4 was adopted to estimate the effects of the results among selected articles. Odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were used to estimate the overall pooled effect. Subgroup analysis, forest plots, funnel plots and Egger’s test for the articles included were also conducted. Results. Three randomized clinical trials and seven cohort studies were finally retrieved, these studies included 685 and 829 patients in the UBED and MED groups, respectively. There were no differences in terms of operation time (MD = -0.92, P =0.72), estimated blood loss (MD = -26.31, P =0.08), complications (MD =0.81, P =0.38) and Oswestry Disability Index (ODI) score (P >0.05 in four subgroup) between the two groups. The visual analog scale (VAS) score of back pain in the UBED group was better than MED group only at 6 months (MD = -0.23, P =0.006) after operation, the VAS score of leg pain in the UBED group was better than that of MED group at 3 mouths (MD = -0.22, P =0.002) and 6 months (MD = -0.24, P =0.006) after operation, the UBED group had a less postoperative length of stay than the MED group (MD = -1.85, P <0.001). The bias analysis showed that there was no potential publication bias in the included literature. Conclusion. This study showed that compared with MED, UBED has the advantages of short hospital stay and good short-term curative effect, but there is no significant difference in long-term efficacy and safety, they can be replaced by each other in clinical application.

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21

Liu, Huiyun, Daniel Heller-Trulli, and Claire Moore. "Abstract 5722: Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5722. http://dx.doi.org/10.1158/1538-7445.am2022-5722.

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Abstract Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an essential step in co-transcriptional mRNA maturation, and abnormal poly(A) site choices have been associated with human diseases, including cancer. Recent work has identified CPSF73 as a promising drug target for inhibiting the growth of specific cancers, and higher level of CPSF73 correlates to poor survival in breast cancer patients. However, our understanding of the regulation of CPSF73 is still at an early stage. Here, we report that a HECT-like E3 ligase, UBE3D, participates in stabilizing CPFS73 protein by preventing its ubiquitin-mediated degradation by the proteasome. Depletion of UBE3D in both non-cancer cells and cancer cells leads to CPSF73 downregulation, a pre-mRNA cleavage defect and dysregulated gene expression. UBE3D dysfunction or chemical inactivation of CPFS73 inhibited migration and invasion as well as stem cell renewal phenotypes in vitro in triple negative breast cancer cells. In addition, genetic overexpression of CPSF73 promoted breast cancer stemness and knocking down of CPSF73 inhibited stem cell renewal property. Together, our findings indicate that targeting the pre-mRNA processing nuclease CPSF73 has potential for breast cancer therapy. This work was supported by the NSF grant NS0224 to C. Moore and the NIH grant R01 GM101010-01A1 to C. Moore. Citation Format: Huiyun Liu, Daniel Heller-Trulli, Claire Moore. Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5722.

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Collado, Manuel, Vanesa Garcia, Jose Miguel Garcia, Isabel Alonso, Luis Lombardia, Ramon Diaz-Uriarte, Luis A. López Fernández, Angel Zaballos, Félix Bonilla, and Manuel Serrano. "Genomic Profiling of Circulating Plasma RNA for the Analysis of Cancer." Clinical Chemistry 53, no. 10 (October 1, 2007): 1860–63. http://dx.doi.org/10.1373/clinchem.2007.089201.

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Abstract Background: The blood of cancer patients is known to contain fragments of RNA released from the tumor. The application of genomic profiling techniques to plasma RNA may allow the unbiased selection of cancer markers in the blood, but the informative value of genomic profiling of plasma RNA is currently unknown. Methods: We used cDNA microarray hybridization to perform genomic profiling of plasma RNA from colorectal cancer (CRC) patients and from healthy donors. From a list of 40 genes differentially upregulated in cancer patients, we randomly selected 4 genes for further characterization. These 4 markers were analyzed by quantitative reverse-transcription PCR in a wide set of samples including paired samples from the same CRC patients before and after surgical resection of the tumor. Results: Three of the selected markers—EPAS1, UBE2D3, and KIAA0101—were confirmed by PCR to be significantly increased in cancer compared to healthy donors. Importantly, 2 of the markers, EPAS1 and UBE2D3, showed a significant decrease after surgery, returning to the levels of healthy donors. Finally, supervised class prediction using these 3 markers correctly (77%) assigned presurgery samples to the CRC group and assigned postsurgery samples from the same patients to the healthy group. Conclusions: Our findings demonstrate the usefulness of gene expression profiling of circulating plasma RNA to find cancer markers of potential clinical value.

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Frank, Hagen, Ariane Dierke, Christoph Brandt-Wunderlich, Eric Bohne, Thomas Kuske, Michael Stiehm, Klaus-Peter Schmitz, and Stefan Siewert. "Numerical design studies of meander structures for self-expanding absorbable stents." Current Directions in Biomedical Engineering 7, no. 2 (October 1, 2021): 735–38. http://dx.doi.org/10.1515/cdbme-2021-2188.

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Abstract Absorbable stents made of poly-L-lactic acid (PLLA) exhibit inferior mechanical properties compared with metal based devices. Therefore, design optimization by means of finite element analysis (FEA) plays an important role in development of high performance absorbable stents. In the present study, three different meander structures made of PLLA material were compared in terms of their radial resistive force (RRF) using FEA. Material tests were performed to obtain input parameters of PLLA for the simulation. FEA was carried out to simulate the RRF and the length change of the meander structures as a function of the diameter. In addition, the numerical results were compared to the experimental outcome using corresponding meander based stents performing radial testing with a segmented head mechanism. Comparable high stresses occurred in the Ubends of the examined stent designs. In designs with a large radius of curvature less stress was observed while crimping. One meander structure developed comparatively higher structural resistance against radially acting forces, due to its curved strut design. In general, FEA revealed consistent results compared to the experimental investigations.

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Al-Mutawalli, Nawala, Walther Sallaberger, and Ali Ubeid Shalkham. "The Cuneiform Documents from the Iraqi Excavation at Drehem." Zeitschrift für Assyriologie und vorderasiatische Archäologie 107, no. 2 (December 30, 2017): 151–217. http://dx.doi.org/10.1515/za-2017-0101.

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Abstract: Drehem, ancient Puzriš-Dagān, is well known as the place of origin of more than 15,000 cuneiform tablets from the Ur III period that were sold on the antiquities markets from 1909 onwards. The State Board of Antiquities and Heritage of Iraq undertook the first controlled excavations at the site in 2007 under the direction of Ali Ubeid Shalkham. The cuneiform texts and fragments found there not only add to the well-known royal archives dealing with cattle, treasure or shoes, but they include many records on crafts and agriculture. With this evidence, the subsistence economy behind this important administrative center and royal palace of the Third Dynasty of Ur becomes more evident. We thank the Iraqi State Board of Antiquities and Heritage, the Iraq Museum Baghdad and Mr Ali Ubeid Shalkham for the permission to publish the tablets from the excavation season of 2007. The stays of Nawala Al-Mutawalli at LMU Munich in 2015 and 2016 in order to prepare this article were generously funded by the Gerda Henkel Stiftung. We are grateful to Margarete van Ess for the invitation to a first meeting in 2013 at the DAI Orientabteilung, Berlin. Thanks are owed to Manuel Molina for his careful reading of this article and his helpful remarks and Frans van Koppen for his editorial care. Walther Sallaberger’s work also contributes to his “Sumerisches Glossar” project. – All photos and plans of the excavation were made by Ali Ubeid Shalkham, the tablets in the Iraq Museum were photographed by Nawala Al-Mutawalli Mahmood. The abbreviations follow the Reallexikon für Assyriologie und Vorderasiatische Archäologie. The online digital resources CDLI (cdli.ucla.edu) and especially BDTNS (bdtns.filol.csic.es) have proven once more to be indispensable for our studies of lexicography and prosopography.

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Chun, Yoon Mok, Sang Ho Lee, Kang Suk Moon, and Min Cheol Chang. "Treatment of dural tear with nerve root herniation after unilateral biportal endoscopic decompression using an epidural blood patch: a case report." Journal of International Medical Research 50, no. 12 (December 2022): 030006052211441. http://dx.doi.org/10.1177/03000605221144147.

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We present a case of a dural tear associated with nerve root herniation following unilateral biportal endoscopic decompression (UBED) that was successfully treated using a computed tomography-guided epidural blood patch. A 60-year-old man underwent UBED for radicular pain because of spinal stenosis at L4–5. A left partial hemilaminectomy and flavectomy were performed; however, the left dorsolateral side dura mater was torn during the procedure. TachoComb® was applied at the dural tear site, and the pain was relieved following UBED. However, 3 weeks post-UBED, the patient reported severe pain with an electric shock-like sensation in the left buttock and posterior thigh region with no other neurologic symptoms. The pain was aggravated by standing and spinal motion. Follow-up lumbar spinal magnetic resonance imaging was performed. Axial images indicated protrusion of the left S2 nerve root through the left dorsolateral side of the dura mater. The patient was further diagnosed with nerve root herniation following a dura mater tear. A computed tomography-guided epidural blood patch was performed, with successful therapeutic results. The outcome of this study indicates that a small dural tear that occurs during minimally invasive spinal surgery can be efficiently treated using an epidural blood patch prior to open surgery.

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Polge, Cécile, Nathalie Koulmann, Agnès Claustre, Marianne Jarzaguet, Bernard Serrurier, Lydie Combaret, Daniel Béchet, Xavier Bigard, Didier Attaix, and Daniel Taillandier. "UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension." International Journal of Biochemistry & Cell Biology 79 (October 2016): 488–93. http://dx.doi.org/10.1016/j.biocel.2016.06.019.

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Torres, Yuri, Arturo Gonzalez-Escribano, and Diego R. Llanos. "uBench: exposing the impact of CUDA block geometry in terms of performance." Journal of Supercomputing 65, no. 3 (April 3, 2013): 1150–63. http://dx.doi.org/10.1007/s11227-013-0921-z.

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Pick, Elah, On-Sun Lau, Tomohiko Tsuge, Suchithra Menon, Yingchun Tong, Naoshi Dohmae, Scott M. Plafker, Xing Wang Deng, and Ning Wei. "Mammalian DET1 Regulates Cul4A Activity and Forms Stable Complexes with E2 Ubiquitin-Conjugating Enzymes." Molecular and Cellular Biology 27, no. 13 (April 23, 2007): 4708–19. http://dx.doi.org/10.1128/mcb.02432-06.

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ABSTRACT DET1 (de-etiolated 1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis thaliana CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Human DET1 has recently been isolated as one of the DDB1- and Cul4A-associated factors, along with an array of WD40-containing substrate receptors of the Cul4A-DDB1 ubiquitin ligase. However, DET1 differs from conventional substrate receptors of cullin E3 ligases in both biochemical behavior and activity. Here we report that mammalian DET1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 associated 1), and a member of the UBE2E group of canonical ubiquitin-conjugating enzymes. DDD-E2 complexes interact with multiple ubiquitin E3 ligases. We show that the E2 component cannot maintain the ubiquitin thioester linkage once bound to the DDD core, rendering mammalian DDD-E2 equivalent to the Arabidopsis CDD complex. While free UBE2E-3 is active and able to enhance UbcH5/Cul4A activity, the DDD core specifically inhibits Cul4A-dependent polyubiquitin chain assembly in vitro. Overexpression of DET1 inhibits UV-induced CDT1 degradation in cultured cells. These findings demonstrate that the conserved DET1 complex modulates Cul4A functions by a novel mechanism.

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Lazic, Nikola. "ANTISISTEMSKI POKRETI U SRBIJI KAO ILUZIJA POLITIČKIH PARTIJA Analiza za vreme izbornih godina od 2014. do 2018: Dosta je bilo, Pokret slobodnih građana, Beli – samo jako, Ne da(vi)mo Beograd." Nacionalni interes 39, no. 3/2020 (February 15, 2021): 109–28. http://dx.doi.org/10.22182/ni.3932020.5.

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Novi pokreti usmeravaju svoje postupke prema civilnim vlastima i političarima koji imaju moć da realizuju ciljeve pokreta, ali često postoji sukob između pokreta i vlasti, odnosno između pokreta i utvrđenog društva koje vlasti predstavljaju. Ti pokreti veruju da su establišment politike propale i da više ne mogu da predstavljaju zadovoljavajuća rešenja za teške političke probleme. Tri najvažnija pristupa društvenih teorija prepoznaju sledeće koncepte: koncept mobilizacije resursa i koncept struktura političkih oportuniteta i koncept freminga (framing), odnosno okvira. Relativni uspeh pobune protiv establišmenta zavisi, u krajnjoj liniji, od sposobnosti političkih aktera da ubede potencijalne pristalice da oni zaista stoje nasuprot elita moći, da nisu deo strukture elite moći, da nisu insajderi. Uspeh pokreta zavisi od širokog prihvatanja poruke, a prihvatanje poruke će zavisiti od toga koliko se ona uklapa u percepciju stvarnosti ili koliko se dobro percepcijom može izmanipulisati. Međutim u Srbiji se samo na početku činilo da će ovi novi pokreti biti vesnici novih političkih trendova i novog svetla u postojeći sistem. Oni su zapravo profitirali samo od slabljenja određenih opozicionih partija ili sindikata, ali kratkog daha. Nisu uspeli i nisu mogli da ustroje stalnu organizaciju i strukturu, jedinstveno članstvo i program.

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Baek, Kheewoong, David T. Krist, J. Rajan Prabu, Spencer Hill, Maren Klügel, Lisa-Marie Neumaier, Susanne von Gronau, Gary Kleiger, and Brenda A. Schulman. "NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly." Nature 578, no. 7795 (February 12, 2020): 461–66. http://dx.doi.org/10.1038/s41586-020-2000-y.

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Oltra Tomás, José Miguel. "Casuística estructural en "La Pícara Justina" de Francisco López de Ubeda." Estudios humanísticos, no. 5 (January 26, 2021): 69. http://dx.doi.org/10.18002/eh.v0i5.6521.

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PÉREZ-GÁLVEZ, Jesús Claudio, Tomás LÓPEZ-GUZMÁN, Miguel Jesús MEDINA-VIRUEL, and Mónica TORRES-NARANJO. "HERITAGE TOURISM IN UBEDA Y BAEZA (SPAIN). WORLD HERITAGE REINASSANCE CITIES." GeoJournal of Tourism and Geosites 26, no. 3 (November 30, 2019): 808–20. http://dx.doi.org/10.30892/gtg.26311-399.

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Nachasova, I. E., and K. S. Burakov. "Archeomagnetic studies of ceramics from the archeological monument in Ubeda, Spain." Izvestiya, Physics of the Solid Earth 47, no. 12 (November 27, 2011): 1086–93. http://dx.doi.org/10.1134/s106935131112007x.

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Pedrosa, José Manuel. "Francisco López De Ubeda, Libro de entretenimiento de la pícara Justina." Criticón, no. 123 (January 1, 2015): 213–16. http://dx.doi.org/10.4000/criticon.1618.

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Uversky, Vladimir N. "The UBE2E Proteins as Conjugating Dispersers: Extending Function with Extended Extensions." Journal of Molecular Biology 425, no. 22 (November 2013): 4067–70. http://dx.doi.org/10.1016/j.jmb.2013.07.024.

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Wang, Xun, Ping Yang, Yongliang Jiang, Yazhou Xu, Nan Wang, Peng Rao, Lin Yang, Lin Sun, and Di Lu. "UBE2D3 contributes to myocardial ischemia-reperfusion injury by regulating autophagy in dependence of p62/SQSTM1." Cellular Signalling 87 (November 2021): 110118. http://dx.doi.org/10.1016/j.cellsig.2021.110118.

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Ghilarducci, Kim, Valérie C. Cabana, Camille Desroches, Kahina Chabi, Steve Bourgault, Laurent Cappadocia, and Marc P. Lussier. "Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor." FEBS Journal 288, no. 16 (March 20, 2021): 4849–68. http://dx.doi.org/10.1111/febs.15796.

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38

Gao, Xiaojia, Wenbo Wang, Hui Yang, Lin Wu, Zhongshi He, Shuliang Zhou, Hong Zhao, Zhenming Fu, Fuxiang Zhou, and Yunfeng Zhou. "UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo." Oncotarget 7, no. 22 (April 20, 2016): 32543–53. http://dx.doi.org/10.18632/oncotarget.8869.

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39

Geisler, Sven, Stefanie Vollmer, Sonia Golombek, and Philipp J. Kahle. "The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy." Journal of Cell Science 127, no. 15 (June 6, 2014): 3280–93. http://dx.doi.org/10.1242/jcs.146035.

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40

Kapenda, D., M. G. Bonhomme, and A. B. Kampunzu. "Le plutonisme ubendien du Nord-Est du Shaba (Zaïre): chronologie K-Ar et implication géodynamique." Journal of African Earth Sciences (and the Middle East) 9, no. 1 (January 1989): 113–21. http://dx.doi.org/10.1016/0899-5362(89)90014-6.

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41

Cieri Via, Claudia. "Sebastiano del Piombo e la Pietà di Ubeda fra narrazione e devozione." Konsthistorisk Tidskrift/Journal of Art History 81, no. 4 (December 2012): 262–69. http://dx.doi.org/10.1080/00233609.2012.731430.

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42

Zhang, L., L. Fairall, B. T. Goult, A. C. Calkin, C. Hong, C. J. Millard, P. Tontonoz, and J. W. R. Schwabe. "The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor." Genes & Development 25, no. 12 (June 15, 2011): 1262–74. http://dx.doi.org/10.1101/gad.2056211.

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Schumacher, Frances-Rose, Georgina Wilson, and Catherine L. Day. "The N-Terminal Extension of UBE2E Ubiquitin-Conjugating Enzymes Limits Chain Assembly." Journal of Molecular Biology 425, no. 22 (November 2013): 4099–111. http://dx.doi.org/10.1016/j.jmb.2013.06.039.

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Schmidt, Christine K., Yaron Galanty, Matylda Sczaniecka-Clift, Julia Coates, Satpal Jhujh, Mukerrem Demir, Matthew Cornwell, Petra Beli, and Stephen P. Jackson. "Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair." Nature Cell Biology 17, no. 11 (October 26, 2015): 1458–70. http://dx.doi.org/10.1038/ncb3260.

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GUAN, GE GE, WEN BO WANG, BING XIN LEI, QIAO LI WANG, LIN WU, ZHEN MING FU, FU XIANG ZHOU, and YUN FENG ZHOU. "UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer." Oncology Letters 9, no. 4 (February 3, 2015): 1567–74. http://dx.doi.org/10.3892/ol.2015.2926.

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46

Robinson, P. A., J. P. Leek, H. C. Ardley, J. Thompson, S. A. Rose, and A. F. Markham. "Assignment¹ of UBE2D1 to human chromosome bands 10q11.2→q21 by in situ hybridization." Cytogenetic and Genome Research 83, no. 3-4 (1998): 247–48. http://dx.doi.org/10.1159/000015195.

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47

Hans, Friederike, Fabienne C. Fiesel, Jennifer C. Strong, Sandra Jäckel, Tobias M. Rasse, Sven Geisler, Wolfdieter Springer, Jörg B. Schulz, Aaron Voigt, and Philipp J. Kahle. "UBE2E Ubiquitin-conjugating Enzymes and Ubiquitin Isopeptidase Y Regulate TDP-43 Protein Ubiquitination." Journal of Biological Chemistry 289, no. 27 (May 13, 2014): 19164–79. http://dx.doi.org/10.1074/jbc.m114.561704.

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48

TOKUMOTO, Maki, and Masahiko SATOH. "Cadmium Induces p53-Dependent Apoptosis Through the Inhibition of Ube2d Family Gene Expression." Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 67, no. 4 (2012): 472–77. http://dx.doi.org/10.1265/jjh.67.472.

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49

Lei, Lei, Joanna Bandola-Simon, and Paul A. Roche. "Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I." Journal of Biological Chemistry 293, no. 11 (February 1, 2018): 3904–12. http://dx.doi.org/10.1074/jbc.ra117.001322.

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50

Kołosowski, Tadeusz. "„Ubi tres, ecclesia est, licet laici". Duchowieństwo a laikat we wspólnocie kartagińskiej według Tertuliana." Vox Patrum 42 (January 15, 2003): 119–30. http://dx.doi.org/10.31743/vp.7147.

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Tertullian war durch den ganzen Zeitraum seines Lebens und Schaffens der Sprecher der Diszipłin. Er bemerkte in der christlichen Gemeinschaft diese, die leiten sie, und andere, die sind ihnen unterordnen. Bischofe, Priester und Diakone gehoren zu erster Gruppe. Die Bischofe leiten besonders die Kirche und sie sind Seelsorger. Sie bewahren auch „munera sacerdotałia". Diesem Gesetz des Bischofs verleugnete Tertullian niemals deutlich. Als zweite, separate Gruppe in der christlichen Gemeinschaft spezifiziert Tertullian die Laien. „Laici", ein mal verheiratete Manner, die zu „ordo Ecclesie" (Kirchrangordnung) nicht gehoren, haben auch die priesterliche Wurde. Die priesterliche Wurde der Glaubigen hat der allgemeine Charakter. Die priesterliche Funktionen uben in der christlichen Gemeinschaft Bischofe, Priester und Diakone, mit der Rucksicht auf der Disziplin und der Ordnung in der Kirche. In den notwendigen Zufallen uben es auch die Laien, das heiBt die Manner. Tertullian lehnt deutlich das Gesetz der Frauen die priesterliche Funktionen auszuuben ab. Trotz der deutlichen Absonderung durch Tertullian zwei Zustande in der Kirche, ist die Linie der Aufteilung zwischen Geistlichern und Laien in den Zeiten Tertullians in dem Grund der Sache genug gelaufig.

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