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Su, Xichao, Yu Wu, Fang Guo, Jiapeng Cui, and Ge Yang. "Trajectory optimization of an unmanned aerial–aquatic rotorcraft navigating between air and water." International Journal of Advanced Robotic Systems 18, no. 2 (March 1, 2021): 172988142199225. http://dx.doi.org/10.1177/1729881421992258.
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Unmanned aerial–aquatic vehicles are a new type of aircraft that can navigate in air and underwater. An unmanned aerial–aquatic rotorcraft (UAAR) is introduced to complete the task of navigating between air and underwater, and the trajectory optimization problem for this task is focused on in this study. The dynamics of a four-axle rotorcraft with eight rotors operating in air and underwater is described. On this basis, the trajectory optimization model is established, wherein the constraints on control variables and states in different media are included. The optimization index is denoted as the weighted sum of the terminal states. In view of the weakness of the teaching- and learning-based optimization (TLBO) algorithm, the formula for updating the individual grade in the teaching process is modified. Thus, this ensures that the algorithm avoids converging at the local optimum and improves the solution quality. Finally, an improved TLBO (ITLBO)-based trajectory optimization method for UAAR navigating between air and water is developed. The control variables are discretized with respect to height at a set of Chebyshev collocation points to reduce the terminal error of states, and the values of control variables at other heights are obtained via interpolation. In the simulation studies, the ITLBO-based method exhibits better performance in terms of optimizing the index when compared to the other two algorithms. Furthermore, the effects of the distribution and number of collocation points on the results are analyzed.
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Zhao, Zhixin, Xiaohui Wu, Guoli Ji, Chun Liang, and Qingshun Li. "Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal." International Journal of Molecular Sciences 20, no. 4 (February 22, 2019): 958. http://dx.doi.org/10.3390/ijms20040958.
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Pre-mRNA cleavage and polyadenylation is an essential step for almost all mRNA in eukaryotes. The cis-elements around the poly(A) sites, however, are very diverse among different organisms. We characterized the poly(A) signals of seven different species, and compared them with that of four well-studied organisms. We found that ciliates do not show any dominant poly(A) signal; a triplet (UAA) and tetramers (UAAA and GUAA) are dominant in diatoms and red alga, respectively; and green alga Ostreococcus uses UGUAA as its poly(A) signal. Spikemoss and moss use conserved AAUAAA signals that are similar to other land plants. Our analysis suggests that the first two bases (NN in NNUAAA) are likely degenerated whereas UAAA appears to be the core motif. Combined with other published results, it is suggested that the highly conserved poly(A) signal AAUAAA may be derived from UAA with an intermediate, putative UAAA, following a pathway of UAA→UAAA→AAUAAA.
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Curnew, Leah Jane Fitzgerald, Kate McNicholas, Bridgette Green, Jackie Barry, Hannah L. Wallace, Lingyan Wang, Cassandra Davidson, John P. Pezacki, and Rodney S. Russell. "Visualizing HCV Core Protein via Fluorescent Unnatural Amino Acid Incorporation." Proceedings 50, no. 1 (July 14, 2020): 129. http://dx.doi.org/10.3390/proceedings2020050129.
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Introduction: Unnatural amino acids (UAAs) share the same basic structure as proteinogenic amino acids. However, UAAs permit additional functions and applications to proteins due to their different side chains. Recent UAA applications include using fluorescent UAAs to label proteins. The UAA system provides an alternative method to traditional protein labeling mechanisms (antibodies, GFP, and tags, such as HA and HIS), which can affect protein functionality and topology. The purpose of this study was to visualize the hepatitis C virus (HCV) core protein using the fluorescent UAA Anap (3-[(6-acetyl-2-naphthalenyl)amino]-L-alanine). Methods: Huh-7.5 cells were co-transfected with HCV core plasmids containing amber stop codons at various positions throughout the coding sequence and a second plasmid encoding the orthogonal tRNA/synthetase pair that facilitates Anap incorporation. Three days post transfection, cells were stained for core protein and lipid droplets (LDs) and visualized using immunofluorescence or confocal microscopy. Results: We have optimized transfection protocols for the efficient expression of the tRNA/synthetase pair required for Anap incorporation and are able to visualize our core mutant proteins containing Anap. We have successfully substituted Anap into 11 different positions within the core, including substitutions for tryptophan, tyrosine, and phenylalanine residues. In addition, we have shown that our core mutants associate with cellular LDs, suggesting that the incorporation of the UAA did not disrupt core protein expression, stability, or cellular localization. Conclusions: We have demonstrated the establishment of a UAA incorporation system in an HCV protein without any obvious impact on core protein function. The ability to label viral proteins using fluorescent UAAs eliminates the requirement of antibodies or tags for protein visualization. In conclusion, the UAA system is a useful method to study HCV proteins and can potentially be used to label viruses for live cell and animal studies.
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Lee, Hannae, Dongchan Kim, Sooin Kim, and Hyun Soo Lee. "Conversion of Racemic Unnatural Amino Acids to Optically Pure Forms by a Coupled Enzymatic Reaction." Molecules 26, no. 5 (February 26, 2021): 1274. http://dx.doi.org/10.3390/molecules26051274.
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Genetic code expansion (GCE) technology is a useful tool for the site-specific modification of proteins. An unnatural amino acid (UAA) is one of the essential components of this technique, typically required at high concentration (1 mM or higher) in growth medium. The supply of UAAs is an important limitation to the application of GCE technology, as many UAAs are either expansive or commercially unavailable. In this study, two UAAs in a racemic mixture were converted into optically pure forms using two enzymes, the d-amino acid oxidase (RgDAAO) from Rhodotorula gracilis and the aminotransferase (TtAT) from Thermus thermophilus. In the coupled enzyme system, RgDAAO oxidizes the d-form of UAAs in a stereospecific manner and produces the corresponding α-keto acids, which are then converted into the l-form of UAAs by TtAT, resulting in the quantitative and stereospecific conversion of racemic UAAs to optically pure forms. The genetic incorporation of the optically pure UAAs into a target protein produced a better protein yield than the same experiments using the racemic mixtures of the UAAs. This method could not only be used for the preparation of optically pure UAAs from racemic mixtures, but also the broad substrate specificity of both enzymes would allow for its expansion to structurally diverse UAAs.
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Dippel, Andrew B., Gregory M. Olenginski, Nicole Maurici, Melanie T. Liskov, Scott H. Brewer, and Christine M. Phillips-Piro. "Probing the effectiveness of spectroscopic reporter unnatural amino acids: a structural study." Acta Crystallographica Section D Structural Biology 72, no. 1 (January 1, 2016): 121–30. http://dx.doi.org/10.1107/s2059798315022858.
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The X-ray crystal structures of superfolder green fluorescent protein (sfGFP) containing the spectroscopic reporter unnatural amino acids (UAAs) 4-cyano-L-phenylalanine (pCNF) or 4-ethynyl-L-phenylalanine (pCCF) at two unique sites in the protein have been determined. These UAAs were genetically incorporated into sfGFP in a solvent-exposed loop region and/or a partially buried site on the β-barrel of the protein. The crystal structures containing the UAAs at these two sites permit the structural implications of UAA incorporation for the native protein structure to be assessed with high resolution and permit a direct correlation between the structure and spectroscopic data to be made. The structural implications were quantified by comparing the root-mean-square deviation (r.m.s.d.) between the crystal structure of wild-type sfGFP and the protein constructs containing either pCNF or pCCF in the local environment around the UAAs and in the overall protein structure. The results suggest that the selective placement of these spectroscopic reporter UAAs permits local protein environments to be studied in a relatively nonperturbative fashion with site-specificity.
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Fuentes, Vanessa, Guadalupe Barrera, Joaquín Sánchez, Roberto Hernández, and Imelda López-Villaseñor. "Functional Analysis of Sequence Motifs Involved in the Polyadenylation of Trichomonas vaginalis mRNAs." Eukaryotic Cell 11, no. 6 (March 30, 2012): 725–34. http://dx.doi.org/10.1128/ec.05322-11.
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ABSTRACTSynthesis of functional mRNA in eukaryotes involves processing of precursor transcripts, including the addition of a poly(A) tail at the 3′ end. A multiprotein complex recognizes a polyadenylation signal, generally the hexanucleotide AAUAAA in metazoans, to direct processing of the pre-mRNA. Based on sequence analysis of several cDNAs, we have previously suggested that the UAAA tetranucleotide (which may include the UAA translation stop codon) could be the polyadenylation signal inTrichomonas vaginalis, a parasitic protozoon that causes human trichomoniasis. This proposal is analyzed here with the aid of a transient-expression system of a reporter gene (catflanked byT. vaginalisactin noncoding sequences). When cells were transfected with a plasmid bearing the original 3′ untranslated region (UTR) sequence containing the UAAA motif, the resultingcatmRNA was polyadenylated similarly to the endogenous actin mRNA. Base changes in the UAAA sequence produced alterations to the polyadenylation site of the reporter mRNAs, while nucleotide substitutions at either side of UAAA did not. Furthermore, relocation of the UAAA motif redirected the processing and polyadenylation of the reporter mRNA. In addition, a pre-mRNA cleavage site for polyadenylation was defined. Interaction ofT. vaginalisproteins with the UAAA motif was shown by electrophoretic mobility shift assays. Based on our findings, we provide evidence that inT. vaginalisthe UAAA tetranucleotide has a role equivalent to that of the metazoan consensus AAUAAA polyadenylation signal.
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Italia, James S., Yunan Zheng, Rachel E. Kelemen, Sarah B. Erickson, Partha S. Addy, and Abhishek Chatterjee. "Expanding the genetic code of mammalian cells." Biochemical Society Transactions 45, no. 2 (April 13, 2017): 555–62. http://dx.doi.org/10.1042/bst20160336.
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In the last two decades, unnatural amino acid (UAA) mutagenesis has emerged as a powerful new method to probe and engineer protein structure and function. This technology enables precise incorporation of a rapidly expanding repertoire of UAAs into predefined sites of a target protein expressed in living cells. Owing to the small footprint of these genetically encoded UAAs and the large variety of enabling functionalities they offer, this technology has tremendous potential for deciphering the delicate and complex biology of the mammalian cells. Over the last few years, exciting progress has been made toward expanding the toolbox of genetically encoded UAAs in mammalian cells, improving the efficiency of their incorporation and developing innovative applications. Here, we provide our perspective on these recent developments and highlight the current challenges that must be overcome to realize the full potential of this technology.
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Wang, Tong-Yun, Guo-Ju Sang, Qian Wang, Chao-Liang Leng, Zhi-Jun Tian, Jin-Mei Peng, Shu-Jie Wang, et al. "Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology." Viruses 14, no. 3 (March 10, 2022): 572. http://dx.doi.org/10.3390/v14030572.
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Despite many efforts and diverse approaches, developing an effective herpesvirus vaccine remains a great challenge. Traditional inactivated and live-attenuated vaccines always raise efficacy or safety concerns. This study used Pseudorabies virus (PRV), a swine herpes virus, as a model. We attempted to develop a live but replication-incompetent PRV by genetic code expansion (GCE) technology. Premature termination codon (PTC) harboring PRV was successfully rescued in the presence of orthogonal system MbpylRS/tRNAPyl pair and unnatural amino acids (UAA). However, UAA incorporating efficacy seemed extremely low in our engineered PRV PTC virus. Furthermore, we failed to establish a stable transgenic cell line containing orthogonal translation machinery for PTC virus replication, and we demonstrated that orthogonal tRNAPyl is a key limiting factor. This study is the first to demonstrate that orthogonal translation system-mediated amber codon suppression strategy could precisely control PRV-PTC engineered virus replication. To our knowledge, this is the first reported PTC herpesvirus generated by GCE technology. Our work provides a proof-of-concept for generating UAAs-controlled PRV-PTC virus, which can be used as a safe and effective vaccine.
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Porter, Douglas F., Yvonne Y. Koh, Brett VanVeller, Ronald T. Raines, and Marvin Wickens. "Target selection by natural and redesigned PUF proteins." Proceedings of the National Academy of Sciences 112, no. 52 (December 14, 2015): 15868–73. http://dx.doi.org/10.1073/pnas.1508501112.
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Pumilio/fem-3 mRNA binding factor (PUF) proteins bind RNA with sequence specificity and modularity, and have become exemplary scaffolds in the reengineering of new RNA specificities. Here, we report the in vivo RNA binding sites of wild-type (WT) and reengineered forms of the PUF protein Saccharomyces cerevisiae Puf2p across the transcriptome. Puf2p defines an ancient protein family present throughout fungi, with divergent and distinctive PUF RNA binding domains, RNA-recognition motifs (RRMs), and prion regions. We identify sites in RNA bound to Puf2p in vivo by using two forms of UV cross-linking followed by immunopurification. The protein specifically binds more than 1,000 mRNAs, which contain multiple iterations of UAAU-binding elements. Regions outside the PUF domain, including the RRM, enhance discrimination among targets. Compensatory mutants reveal that one Puf2p molecule binds one UAAU sequence, and align the protein with the RNA site. Based on this architecture, we redesign Puf2p to bind UAAG and identify the targets of this reengineered PUF in vivo. The mutant protein finds its target site in 1,800 RNAs and yields a novel RNA network with a dramatic redistribution of binding elements. The mutant protein exhibits even greater RNA specificity than wild type. The redesigned protein decreases the abundance of RNAs in its redesigned network. These results suggest that reengineering using the PUF scaffold redirects and can even enhance specificity in vivo.
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Dagger, Claire. "Uair Amháin Eile." Comhar 60, no. 12 (2000): 28. http://dx.doi.org/10.2307/25574163.
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Colhoun, Anna. "Uair Amháin Eile." Comhar 64, no. 5 (2004): 18. http://dx.doi.org/10.2307/25574885.
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Gonçalves Alves, Dayse Lorrane, Francisco José Maia Pinto, Ana Carina Stelko-Pereira, Bruna Rodrigues Nunes, Steffany Rocha Da Silva, and Tayane Carneiro Cruz. "Uso de álcool por adolescentes envolvidos em bullying e cyberbullying, como autores, vítimas e autores-vítimas: uma revisão sistemática da literatura." Gerencia y Políticas de Salud 20 (December 30, 2021): 1–26. http://dx.doi.org/10.11144/javeriana.rgps20.uaab.
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Objetivo. Sintetizar, mediante revisão sistemática, as evidências científicas sobre as associações entre o uso de álcool e o envolvimento em bullying e cyberbullying na adolescência. Materiais e métodos. A busca foi realizada em quatro bases de dados: PubMed, Medline, SciELO e Web of Science. Foram selecionados 58 artigos com base nos critérios de elegibilidade. A avaliação da qualidade metodológica dos estudos foi realizada por meio de um instrumento do National Heart, Lung and Blood Institute. Resultado. Os estudos que atingiram classificação de boa qualidade metodológica apresentaram os seguintes achados: vitimização e autoria por bullying ou cyberbullying foram associados ao consumo de álcool; o sofrimento psicológico mediou parcialmente a associação entre vitimização por cyberbullying e uso posterior de álcool; o bullying e a perpetração violenta mediaram a relação entre violência na família e uso de álcool e outras drogas; sintomas depressivos e uso de álcool são preditores de mais vitimização por bullying, e a vitimização relacional esteve associada ao uso precoce de álcool. Conclusões. A maioria dos estudos indicou que adolescentes envolvidos em bullying e cyberbullying têm maiores chances de fazer uso de álcool do que adolescentes não envolvidos, sendo que autores fazem maior uso de álcool em relação aos autores-vítimas e às vítimas.
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Pháidín, Caoilfhionn Nic, and Ciarán Ó. Coigligh. "Doineann agus Uair Bhreá." Comhar 45, no. 4 (1986): 31. http://dx.doi.org/10.2307/20555966.
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Olenginski, Gregory M., Juliana Piacentini, Darcy R. Harris, Nicolette A. Runko, Brianna M. Papoutsis, Jordan R. Alter, Kenneth R. Hess, Scott H. Brewer, and Christine M. Phillips-Piro. "Structural and spectrophotometric investigation of two unnatural amino-acid altered chromophores in the superfolder green fluorescent protein." Acta Crystallographica Section D Structural Biology 77, no. 8 (July 29, 2021): 1010–18. http://dx.doi.org/10.1107/s2059798321006525.
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The spectrophotometric properties of the green fluorescent protein (GFP) result from the post-translationally cyclized chromophore composed of three amino acids including a tyrosine at the center of the β-barrel protein. Altering the amino acids in the chromophore or the nearby region has resulted in numerous GFP variants with differing photophysical properties. To further examine the effect of small atomic changes in the chromophore on the structure and photophysical properties of GFP, the hydroxyl group of the chromophore tyrosine was replaced with a nitro or a cyano group. The structures and spectrophotometric properties of these superfolder GFP (sfGFP) variants with the unnatural amino acids (UAAs) 4-nitro-L-phenylalanine or 4-cyano-L-phenylalanine were explored. Notably, the characteristic 487 nm absorbance band of wild-type (wt) sfGFP is absent in both unnatural amino-acid-containing protein constructs (Tyr66pNO2Phe-sfGFP and Tyr66pCNPhe-sfGFP). Consequently, neither Tyr66pNO2Phe-sfGFP nor Tyr66pCNPhe-sfGFP exhibited the characteristic emission of wt sfGFP centered at 511 nm when excited at 487 nm. Tyr66pNO2Phe-sfGFP appeared orange due to an absorbance band centered at 406 nm that was not present in wt sfGFP, while Tyr66pCNPhe-sfGFP appeared colorless with an absorbance band centered at 365 nm. Mass spectrometry and X-ray crystallography confirmed the presence of a fully formed chromophore and no significant structural changes in either of these UAA-containing protein constructs, signaling that the change in the observed photophysical properties of the proteins is the result of the presence of the UAA in the chromophore.
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Xie, Xiangkun, Zhengliang Peng, Hanlin Li, Dan Li, Yan Tu, Yujia Bai, Xingfu Huang, et al. "Association of Urine Albumin/Creatinine Ratio below 30 mg/g and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes." BioMed Research International 2020 (January 22, 2020): 1–9. http://dx.doi.org/10.1155/2020/5240153.
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Several studies show that even a level of urine albumin/creatinine ratio (UACR) within the normal range (below 30 mg/g) increases the risk of cardiovascular diseases. We speculate that mildly increased UACR is related to left ventricular hypertrophy (LVH) in patients with type 2 diabetes mellitus (T2DM). In this retrospective study, 317 patients with diabetes with normal UACR, of whom 62 had LVH, were included. The associations between UACR and laboratory indicators, as well as LVH, were examined using multivariate linear regression and logistic regression, respectively. The diagnostic efficiency and the optimal cutoff point of UACR for LVH were evaluated using the area under the receiver operating characteristic curve (AUC) and Youden index. Our results showed that patients with LVH had significantly higher UACR than those without LVH (P<0.001). The prevalence of LVH presented an upward trend with the elevation of UACR. UACR was independently and positively associated with hemoglobin A1c (P<0.001). UACR can differentiate LVH (AUC = 0.682, 95% CI (0.602–0.760), P<0.001). The optimal cutoff point determined with the Youden index was UACR = 10.2 mg/g. When categorized by this cutoff point, the odds ratio (OR) for LVH in patients in the higher UACR group (10.2–30 mg/g) was 3.104 (95% CI: 1.557–6.188, P=0.001) compared with patients in the lower UACR group (<10.2 mg/g). When UACR was analyzed as a continuous variable, every double of increased UACR, the OR for LVH was 1.511 (95% CI: 1.047–2.180, P=0.028). Overall, UACR below 30 mg/g is associated with LVH in patients with T2DM. The optimal cutoff value of UACR for identifying LVH in diabetes is 10 mg/g.
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Poulsen, Mette H., Anahita Poshtiban, Viktoria Klippenstein, Valentina Ghisi, and Andrew J. R. Plested. "Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis." Proceedings of the National Academy of Sciences 116, no. 27 (June 18, 2019): 13358–67. http://dx.doi.org/10.1073/pnas.1818845116.
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Ionotropic glutamate receptors (iGluRs) are responsible for fast synaptic transmission throughout the vertebrate nervous system. Conformational changes of the transmembrane domain (TMD) underlying ion channel activation and desensitization remain poorly understood. Here, we explored the dynamics of the TMD of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type iGluRs using genetically encoded unnatural amino acid (UAA) photocross-linkers, p-benzoyl-l-phenylalanine (BzF) and p-azido-l-phenylalanine (AzF). We introduced these UAAs at sites throughout the TMD of the GluA2 receptor and characterized the mutants in patch-clamp recordings, exposing them to glutamate and ultraviolet (UV) light. This approach revealed a range of optical effects on the activity of mutant receptors. We found evidence for an interaction between the Pre-M1 and the M4 TMD helix during desensitization. Photoactivation at F579AzF, a residue behind the selectivity filter in the M2 segment, had extraordinarily broad effects on gating and desensitization. This observation suggests coupling to other parts of the receptor and like in other tetrameric ion channels, selectivity filter gating.
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Luo, Xinwei, Lu Chen, Hanlu Zhou, and Hongli Cao. "A Survey of Underwater Acoustic Target Recognition Methods Based on Machine Learning." Journal of Marine Science and Engineering 11, no. 2 (February 9, 2023): 384. http://dx.doi.org/10.3390/jmse11020384.
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Underwater acoustic target recognition (UATR) technology has been implemented widely in the fields of marine biodiversity detection, marine search and rescue, and seabed mapping, providing an essential basis for human marine economic and military activities. With the rapid development of machine-learning-based technology in the acoustics field, these methods receive wide attention and display a potential impact on UATR problems. This paper reviews current UATR methods based on machine learning. We focus mostly, but not solely, on the recognition of target-radiated noise from passive sonar. First, we provide an overview of the underwater acoustic acquisition and recognition process and briefly introduce the classical acoustic signal feature extraction methods. In this paper, recognition methods for UATR are classified based on the machine learning algorithms used as UATR technologies using statistical learning methods, UATR methods based on deep learning models, and transfer learning and data augmentation technologies for UATR. Finally, the challenges of UATR based on the machine learning method are summarized and directions for UATR development in the future are put forward.
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Liu, Yang, Longlong Li, Yajia Liu, Xiongkui He, Jianli Song, Aijun Zeng, and Zhichong Wang. "Assessment of Spray Deposition and Losses in an Apple Orchard with an Unmanned Agricultural Aircraft System in China." Transactions of the ASABE 63, no. 3 (2020): 619–27. http://dx.doi.org/10.13031/trans.13233.
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Highlights Field tests were performed in an orchard to evaluate spray performance of an unmanned agricultural aircraft system. A conventional air-assisted orchard sprayer was applied as a reference for comparing the feasibility of UAAS. The canopy deposition, airborne drift, loss to ground, and sprayer external contamination were tested. Field test results can provide a reference for the application of UAAS for pest control in orchards. Abstract. Unmanned agricultural aircraft system (UAAS) technology has developed rapidly in China in recent years. Due to their high application efficiency, all-terrain operation, and low-volume spraying, UAASs have been widely used for pest management in field crops, achieving good pest control and reduced pressure on farmers. In this study, the applicability of UAAS for orchard protection was tested in an apple orchard by spraying with a four-rotor UAAS and a conventional air-assisted orchard sprayer. The spray characteristics of both sprayers, including canopy deposition, drift in the air, loss to the ground, and external contamination on the sprayer, were measured and compared. The field results showed that the effective spray swath width of the UAAS was 2.23 m, and the maximum droplet density was 132 droplets cm -2 in the center of the flight line. The actual deposition in the tree canopy was lower with the UAAS than with the air-assisted sprayer, but the normalized deposition of the UAAS was equivalent to that of the air-assisted sprayer, and the coefficient of variation for deposition in all parts of the canopy was obviously higher for the UAAS than for the air-assisted sprayer. Due to the airflow produced by the high-speed rotors, the spray drift in the air was much higher with the UAAS than with the air-assisted sprayer, whereas the ground loss of the UAAS was 1/5 that of the air-assisted sprayer. Moreover, the rotor airflow of the UAAS caused a large amount of droplets to attach to the sprayer fuselage, causing the external contamination on the UAAS to be five times that of the air-assisted sprayer. Results showed that the use of a multirotor UAAS for plant protection in an orchard had considerable influence on the spray drift and external contamination of the spray equipment. Based on the results, the following recommendations can be made: (1) plant protection with a UAAS should be attained by spraying at a reasonable height to reduce the drift in the air, and (2) UAAS manufacturers should develop adequate spraying systems as well as appropriate UAAS designs for plant protection. Keywords: Air-assisted orchard sprayer, Apple orchard, Spray deposition, Spray loss, UAAS.
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Basset, Marco, Paolo Milani, Virginia Valeria Ferretti, Mario Nuvolone, Andrea Foli, Francesca Benigna, Martina Nanci, et al. "Prospective urinary albumin/creatinine ratio for diagnosis, staging, and organ response assessment in renal AL amyloidosis: results from a large cohort of patients." Clinical Chemistry and Laboratory Medicine (CCLM) 60, no. 3 (January 13, 2022): 386–93. http://dx.doi.org/10.1515/cclm-2021-0912.
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Abstract Objectives Quantification of 24 h-proteinuria is the gold standard for diagnosing, staging, and monitoring of patients with renal AL amyloidosis. However, 24 h-urine collection is cumbersome and may result in preanalytical error. In this prospective study, we investigated the role of urinary albumin/creatinine ratio (UACR) (cut-off: 300 mg/g) identifying renal involvement, evaluated a UACR-based staging system (UACR cut-off: 3,600 mg/g) and assessed whether UACR response (UACR decrease >30% without worsening in eGFR >25%) predicts renal outcome in 531 patients with newly-diagnosed AL amyloidosis. Methods From October 2013 paired 24 h-proteinuria and UACR (on first morning void) were measured in all newly-diagnosed patients with AL amyloidosis. Correlation between 24 h-proteinuria and UACR at baseline was assessed by Pearson’s r test. Impact of UACR response on renal outcome was assessed in randomly created testing (n=354) and validation (n=177) cohorts. Results A strong linear correlation was found between 24 h-proteinuria and UACR at baseline (r=0.90; p<0.001). After a median follow-up of 31 months, 57 (11%) patients required dialysis. A UACR-based renal staging system identified three stages with significantly higher dialysis rate at 36 months comparing stage I with stage II and stage II with stage III. Achieving a renal response, according to a UACR-based criterion, resulted in lower dialysis rate in both testing and validation cohorts. Conclusions UACR is a reliable marker for diagnosis, prognosis, and organ response assessment in renal AL amyloidosis and can reliably replace 24 h-proteinuria in clinical trials and individual patients’ management.
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Jian, Guihua, Wenjun Lin, Niansong Wang, Junnan Wu, and Xianfeng Wu. "Urine Albumin/Creatinine Ratio and Microvascular Disease in Elderly Hypertensive Patients without Comorbidities." BioMed Research International 2021 (February 13, 2021): 1–8. http://dx.doi.org/10.1155/2021/5560135.
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Objectives. A high urine albumin/creatinine ratio (UACR) is associated with microvascular disease in hypertensive patients. However, hypertensive patients frequently have other comorbidities. Thus, it is difficult to distinguish the role of UACR from that of comorbidities in microvascular disease. The aim of this study was to evaluate the association between UACR and microvascular disease in elderly hypertension patients without comorbidities. Methods. A cross-sectional cohort study of 2252 essential hypertension patients aged 65-94 years without comorbidities between January 1, 2016, and December 31, 2017, was conducted. Microvascular disease was evaluated by hypertension retinopathy (HR). Multivariable adjusted odds of HR by UACR quartiles were determined using logistic regression. Results. The HR prevalence was 22.1% ( n = 472 ) among the cohort study and was significantly different among UACR quartiles (19.7%, 20.3%, 22.0%, and 26.4% in quartiles 1, 2, 3, and 4, respectively, P = 0.036 ). After adjustment for covariates, higher UACR ( odds ratio OR = 1.42 , 95% confidence interval (CI) 1.05-1.92, quartile 4 versus 1) were significantly associated with HR. Among male patients, higher UACR ( OR = 1.65 , 95% CI 1.07-2.55, quartile 4 versus 1) were significantly associated with HR after adjustment for covariates. Among female patients, however, 64% and 40% increased odds of HR were noted in the highest and lowest UACR (quartiles 4 and 1, respectively) compared to UACR quartile 2. Conclusions. Microvascular disease was associated with higher UACR in elderly male essential hypertension patients without comorbidities but was associated with lower and higher UACR in female patients without comorbidities.
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Morley, Vincent. "Uair na cinniúna i Nicearagua?" Comhar 49, no. 2 (1990): 10. http://dx.doi.org/10.2307/25571203.
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Midhe, Torlach Mac Con. "Uair na Cinniúna i Québec." Comhar 57, no. 1 (1998): 9. http://dx.doi.org/10.2307/25573442.
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CLAUSEN, Peter, Bo FELDT-RASMUSSEN, Gorm JENSEN, and JanSkov JENSEN. "Endothelial haemostatic factors are associated with progression of urinary albumin excretion in clinically healthy subjects: a 4-year prospective study." Clinical Science 97, no. 1 (May 21, 1999): 37–43. http://dx.doi.org/10.1042/cs0970037.
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A slightly elevated urinary albumin excretion rate (UAER), above 5-10 µg/min, is a predictor of atherosclerotic cardiovascular disease. Endothelial dysfunction is an important early feature of atherosclerosis. The plasma concentration of von Willebrand factor (vWF), a potential marker of endothelial dysfunction, predicts a subsequent increase of UAER in patients with diabetes. The aim of this study is to test the hypothesis that high concentrations of vWF as well as other haemostatic factors predict progression of UAER in clinically healthy subjects. UAER was measured together with selected markers of haemostatic function - vWF, tissue plasminogen activator (tPA), plasminogen activator inhibitor, factor VII and fibrinogen - in healthy volunteers aged 40-65 years. After a mean follow-up of 4.1 years, 64 of 74 agreed to a re-examination including re-measurement of UAER. Baseline vWF and tPA were both positively correlated to the change in UAER during follow-up (r = 0.26, P = 0.04 and r = 0.40, P = 0.001 respectively). The mean UAER increased significantly by 7.6 µg/min and 7.5 µg/min respectively in subjects with vWF and tPA above the medians at baseline (P = 0.01 and P = 0.003 respectively), whereas no changes in UAER were seen in subjects with vWF and tPA below the medians. Subjects with high tPA were also characterized by an excess of other cardiovascular risk factors at baseline. No significant differences in these risk factors were present between subjects with high or low vWF. High plasma concentrations of vWF and tPA are associated with progression of UAER in clinically healthy subjects. Both vWF and tPA are secreted by endothelial cells and the results suggest that endothelial dysfunction leads to progression of UAER.
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Ganesan, Surendar, Balasubramanian Esakki, Silambarasan Mathiyazhagan, and Vikram Pandimuthu. "DESIGN CONCEPTION AND EVALUATION OF AN UNMANNED AMPHIBIOUS AERIAL VEHICLE USING SYSTEMATIC APPROACH." Aviation 26, no. 1 (March 30, 2022): 41–53. http://dx.doi.org/10.3846/aviation.2022.16519.
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This article’s incitement interprets Unmanned Amphibious Aerial Vehicle (UAAV)’s conceptual design process in a systematic approach. The UAAV is conceptualised to be an ideal tool for limnologists in water quality assessment. Integration of hovercraft with the multi-rotor system helps collect water samples from remote and inaccessible water bodies. The UAAV flies in multi-rotor mode, subsequently land and glide along the water surface in hovercraft mode. The new and unconventional vehicle configuration makes the conceptual stage a challenging one in the design process. To overcome the challenges and strapped configuration of vehicle design, the Authors used a systematic approach of scenario-based design, morphological matrix, and Pugh’s method in the design process of the “Pahl & Beitz” model to retrieve the best possible UAAV design. The conglomerate design of UAAV is evaluated for its design requirements, and the computational analysis is performed to examine the mechanical strength and flow characteristics of UAAV. The experimental prototype of UAAV demonstrates the competence of flying in the air and hovering in water through field trials.
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Visram, Alissa, Abdullah S. Al Saleh, Eli Muchtar, Jennifer McDonald, Harsh V. Parmar, Iuliana Vaxman, Angela Dispenzieri, Francis Buadi, Morie A. Gertz, and Nelson Leung. "Correlation between 24-hour proteinuria and spot urine albumin to creatinine ratio in systemic light chain amyloidosis." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 8549. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.8549.
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8549 Background: Proteinuria evaluation is essential for diagnosing and monitoring of renal involvement in light chain (AL) amyloidosis. A 24 hour protein collection (24h UP) is the gold standard for proteinuria assessment however it is cumbersome and can be inaccurate. A spot urine albumin to creatinine ratio (uACR) has been proposed as a convenient method to estimate 24hUP. We aimed to validate the correlation between uACR and 24hUP in a large cohort of patients. Methods: We retrospectively studied systemic AL amyloidosis patients evaluated between 2010 and 2019 at Mayo Clinic, with a uACR and 24hUP collected less than 7 days apart. Linear regression analysis was used to construct a prediction model for 24hUP with uACR as the primary predictor. Possible confounders (age, gender, body mass index, morning versus afternoon spot urine collection, estimated glomerular filtration rate) for the primary relationship between uACR and 24h UP were evaluated in the model. We used receiver operating characteristic (ROC) analysis to identify the best uACR cutoff to predict significant proteinuria (defined as a 24hUP > 500mg). Results: We included 665 patients, with a median age of 66 years (IQR 59-72). The spot urine was collected in the morning (before 1200 hours) in 382 (57%) patients, and in the afternoon in 283 (43%) patients. The median 24hUP was 321 (IQR 129-2512.5) mg, median uACR was 107 (IQR 13.5-1845) mg/g, and median serum creatinine was 1.2 (IQR 1-1.8) mg/dL. The uACR correlated well with 24h UP (Pearson’s r= 0.83, 95% CI 0.80-0.85). Linear regression showed that E (24h UPi) = 362 + 1.05(uACRi), and this model was statistically and clinically significant (p < 0.001 and R2 of 0.68, respectively). Age, gender, body mass index, eGFR, and time of day of spot urine collection did not confound the primary relationship between uACR and 24hUP, and no collinearity was observed. A uACR cutoff of > 280 mg/g was the best predictor of a 24hUP > 500 mg (area under the ROC curve 0.98, sensitivity 92%, specificity 97%). For simplicity, we assessed the predictive value of uACR > 300 mg/g for 24h UP > 500 mg. Among patients with 24huACR > 300 mg/g 264 (96%) had a 24hUP > 500 mg, and 31 (7%) of patients with uACR < 300 mg/g had a 24h UP > 500 mg (p < 0.001). Conclusions: In systemic AL amyloid patients, we showed that uACR on a random urine sample correlated well with 24h UP, and can be used to estimate proteinuria with a linear regression model. Based on these findings, and the convenience of uACR testing for patients, we propose that uACR should be used to monitor renal response to AL amyloidosis therapy.
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Oikonomidis, Ioannis L., Nectarios Soubasis, Jose Joaquin Ceron, Konstantina Theodorou, Timoleon Rallis, and Zoe Polizopoulou. "The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis." Acta Veterinaria 69, no. 1 (March 1, 2019): 116–22. http://dx.doi.org/10.2478/acve-2019-0008.
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Abstract Increased urine albumin concentration (UALB) or urine albumin-to-creatinine ratio (UACR) at admission has been associated with systemic disease and increased morbidity and mortality in critically ill canine patients. The objective of this study was to assess the prognostic value of UALB and UACR for the survival, as well as for the development and duration of systemic inflammatory response syndrome (SIRS) in puppies with canine parvoviral enteritis (CPVE). Unvaccinated puppies, aged 1-12 months with confirmed CPVE, hospitalized for ≥5 days were included. Urine was collected at admission via cystocentesis; albumin was measured immunoturbidimetrically and creatinine spectrophotometrically. The presence of SIRS was daily evaluated. Statistical analysis was conducted using R language. Twenty-six dogs were enrolled; 12/26 (46%) developed SIRS during hospitalization, while 5/26 (19%) died. A significant correlation was found between UALB and UACR (ϱ=0.868, p<0.001). The dogs with SIRS had higher median UALB [0.5 (0-12.7) mg/dL] and UACR [4.2 (0-2,093) mg/g] compared to dogs without SIRS [UALB= 0.1 (0-0.8) mg/dL, UACR= 1.6 (0-5.6) mg/g], but the differences were non-significant (p>0.05). SIRS duration was significantly correlated with UACR (ϱ=0.427, p=0.030), but not with UALB (ϱ=0.386, p=0.052). The non-survivors had higher median UALB [0.6 (0.1-12.7) mg/dL] and UACR [19.6 (0.7-2,093) mg/g] compared to survivors [UALB= 0.2 (0-1.5) mg/dL, UACR= 2.3 (0-16.9) mg/g], but the differences were non-significant (p>0.05). UACR appears to be a prognostic indicator of SIRS duration in puppies with CPVE. However, a large-scale study is warranted to confirm the usefulness of UALB and UACR for clinical risk assessment in puppies with CPVE.
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Pecis, Miriam, Lérida M. A. Zaslavsky, Fabrício B. Mallmann, Larissa Pante, Ana L. D. Krahe, Fernanda F. Stringhari, and Luis H. Canani. "Visceral obesity is associated with higher urinary albumin excretion levels in normoalbuminuric type 2 diabetic patients." Arquivos Brasileiros de Endocrinologia & Metabologia 50, no. 3 (June 2006): 466–71. http://dx.doi.org/10.1590/s0004-27302006000300009.
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AIM: To analyze the relationship between visceral obesity and urinary albumin excretion rate (UAER). METHODS: A cross-sectional study of 73 normoalbuminuric (urinary albumin excretion rate < 20 µg/min) type 2 patients was performed. Patients were divided into two groups according to the median of UAER (7.5 µg/min). Office auscultatory blood pressure was measured in sitting position after a 10-min rest. RESULTS: Waist to hip ratio was higher in the group with UAER > 7.0 µg/min (0.98 ± 0.08), when compared to the other group (0.93 ± 0.08, p= 0.01). Waist to hip ratio significantly correlated with UAER (r= 0.28; p= 0.018). In multiple linear regression analysis, only waist to hip ratio was associated with UAER (r= 0.29; p= 0.04). A1c, DM duration and systolic BP levels were excluded from the model. CONCLUSIONS: Type 2 normoalbuminuric diabetic patients with higher levels of UAER could represent a group with an elevated risk for the development of cardiovascular diseases.
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Hoskera, Sharana Basava, Avinash Hanbe Rajanna, Nitish Ashok Gurav, and Ashok ML. "Study of association of urine albumin to creatinine ratio with endothelial dysfunction in HIV patients on HAART." Asian Journal of Medical Sciences 12, no. 3 (March 1, 2021): 70–74. http://dx.doi.org/10.3126/ajms.v12i3.34009.
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Background: In HIV (Human immunodeficiency virus) positive patients several factors have been proposed to explain the cardiovascular (CV) risk, which include pro-athero-thrombotic viral effect, infection-mediated immune dysfunction and possible effects of HAART(Highly active antiretroviral therapy). Presence of endothelial dysfunction, an early CV risk marker, in HIV-infected patients on long-term HAART. Endothelial dysfunction can be measured by bFMD (Brachial artery flow mediated vasodilatation). Urine albumin to creatinine ratio (UACR) is frequent in HIV patients and is predictor of cardiovascular risk. UACR and endothelial dysfunction are positively associated in HIV affected patients thereby increased UACR might help to identify endothelial dysfunction in HIV patients on HAART.
Aims and Objectives: • To measure urine albumin to creatinine ratio in HIV patients on HAART. • To find out correlation between UACR and bFMD.
Materials and Methods: Study was conducted on HIV Patients admitted to hospital, considering the inclusion and exclusion criteria. Detailed clinical history, examination and Blood investigations were done. Endothelial function was assessed by brachial artery flow mediated vasodilatation(bFMD).
Results: Among 100 HIV patients, 14% had UACR <30 and 86% had UACR >30 and mean UACR is 90 ±06. Mean BFMD was 8.44 ± 7.65. We identified a significant Negative correlations were found between bFMD and UACR(r=- 0.832, P=<0.001).
Conclusion: Use of urine albumin to creatinine ratio (UACR) as a routine screening tests in those who are HIV positive on HAART can be used to find out those cases of HIV who are progressing towards cardiovascular impairment so that newer approaches can be used in them to prevent further cardiovascular involvement.
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Ito, Sadayoshi, Naoki Kashihara, Kenichi Shikata, Masaomi Nangaku, Takashi Wada, Yasuyuki Okuda, and Tomoko Sawanobori. "Efficacy and safety of esaxerenone (CS-3150) in Japanese patients with type 2 diabetes and macroalbuminuria: a multicenter, single-arm, open-label phase III study." Clinical and Experimental Nephrology 25, no. 10 (June 10, 2021): 1070–78. http://dx.doi.org/10.1007/s10157-021-02075-y.
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Abstract Background Esaxerenone has potential renoprotective effects and reduces the urinary albumin-to-creatinine ratio (UACR) in patients with diabetic kidney disease and overt nephropathy. We investigated the efficacy and safety of esaxerenone in Japanese patients with type 2 diabetes (T2D) and macroalbuminuria (UACR ≥ 300 mg/g creatinine). Methods We conducted a multicenter, single-arm, open-label phase III study in 56 patients with T2D and UACR ≥ 300 mg/g creatinine with estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m2 and treated with a renin–angiotensin system inhibitor. Patients received esaxerenone for 28 weeks at 1.25 mg/day initially with titration to 2.5 mg/day based on serum potassium (K+) monitoring. Efficacy was evaluated as the change in UACR from baseline to week 28. Safety endpoints included adverse events (AEs), incidence of serum K+ increase, and change in eGFR from baseline. Results UACR decreased by 54.6% (95% CI 46.9%, 61.3%) on average from baseline (544.1 mg/g creatinine) to the end of treatment (246.8 mg/g creatinine); 51.8% of patients showed improvement to early nephropathy. AE incidence was 69.6%. Three patients (5.4%) had serum K+ levels ≥ 6.0 mEq/L or ≥ 5.5 mEq/L on two consecutive occasions. Hyperkalemia in two patients was transient and resolved during the treatment period. One patient discontinued following two consecutive serum K+ values ≥ 5.5 mEq/L. The maximum change from baseline in eGFR was − 8.3 mL/min/1.73 m2 at week 24. Conclusions Esaxerenone reduced UACR in Japanese patients with T2D and UACR ≥ 300 mg/g creatinine; more than half experienced a transition from UACR ≥ 300 mg/g creatinine to UACR < 300 mg/g creatinine. Clinical trial registration JapicCTI-173696
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Hoanca, Bogdan, and David Fitzgerald. "Outage at UAA." Journal of Cases on Information Technology 15, no. 2 (April 2013): 34–41. http://dx.doi.org/10.4018/jcit.2013040102.
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With redundant hardware, it is rare that a disk failure results in downtime at the system level. System failures do sometimes occur, typically as a sequence of very rare events that leads to a catastrophic failure. This case describes how a combination of hardware and firmware failures, along with human error, led to the failure of a redundant disk storage unit, which in turn affected several enterprise systems at a major public university. Subsequently, a small number of conservative and seemingly “good” decisions in the process of restoring the system from backups led to negative outcomes, primarily additional downtime over the course of several days. The case illustrates how even well-considered and conservative decisions may seem flawed in hindsight. An important lesson from the case is that it is difficult to justify to management the provision of sufficient backup resources to prevent very low-probability failure events.
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DREYFUSS, JULIANA L., CAIO V. REGATIERI, BRUNO COELHO, JOSÉ B. BARBOSA, DENISE DE FREITAS, HELENA B. NADER, and JOÃO R. MARTINS. "Altered hyaluronic acid content in tear fluid of patients with adenoviral conjunctivitis." Anais da Academia Brasileira de Ciências 87, no. 1 (February 24, 2015): 455–62. http://dx.doi.org/10.1590/0001-3765201520140122.
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The adenoviral conjunctivitis is one of the biggest causes of conjunctival infection in the world. Conjunctivitis causes relatively nonspecific symptoms, as hyperaemia and chemosis. Even after biomicroscopy, complex laboratory tests, such as viral culture, are necessary to identify the pathogen or its etiology. To contribute to the better understanding of the pathobiology of the adenoviral conjunctivitis, the tear fluids of patients with unilateral acute adenovirus conjunctivitis (UAAC), normal donors (control) and patients with allergic conjunctivitis were analyzed. Tear samples were collected with Schirmer strips from control, allergic conjunctivitis and UAAC patients, diagnosed by clinical signs. UAAC tears were tested positive in viral cultures. After the elution, HA was quantified using an ELISA-like fluorometric assay and the protein profile was determined by SDS-PAGE. A profound increase in the HA tear content in UAAC patients was found when compared to control and ALC. This HA increase in UAAC tears remarkably was not observed in tears from contralateral eyes without clinical signs, nor in allergic conjunctivitis. In addition a distinct profile of UAAC tear proteins was observed in patients with UAAC. The quantification of HA in the tear fluid is a rapid, sensitive and specific test. This molecule might be a biomarker candidate for acute conjunctivitis.
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Sinha, Rajeev, Jeffrey Johnson, Kiley Power, Aaron Moodie, Emily Warhurst, and Roberto Barbosa. "Understanding Spray Attributes of Commercial UAAS as Impacted by Operational and Design Parameters." Drones 6, no. 10 (September 28, 2022): 281. http://dx.doi.org/10.3390/drones6100281.
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Unmanned airborne application systems (UAAS) have recently gained momentum for the application of crop protection (CP) products. Due to their high operational efficiency, mobility, and low cost, UAAS may be perceived as a more viable option for spray application when compared to conventional application techniques, especially backpack/knapsack sprayers. However, being a relatively new technology and not a common practice in the USA, there are no best management practices or guidelines for testing UAAS spray performance. Therefore, this study was undertaken to assess the impact of different attributes pertinent to UAAS flight (e.g., altitude, speed, etc.), application (e.g., droplet size, tank additive, etc.), and UAAS design (e.g., nozzle placement) on spray performance. The spray performance was evaluated in terms of swath and spray drift (ground and airborne) using water-sensitive papers (WSP) and mylar card/string samplers, respectively. The samplers were respectively analyzed using image processing and fluorometry techniques. The different treatments under study were UAAS type (MG-1P and AG V6A+), flight altitude (1.5, 2.5, and 4.0 m) and speed (2 and 3 ms−1), and nozzle type (XR11001 and XR8002 flat fan nozzles) with different droplet volume median diameter (VMD) at ~207 kPa (very fine [140 µm] and fine [196 µm], respectively). The results indicated a highly variable swath for both platform types. While nozzles under each rotor may be a common design in commercial UAAS, the results indicated that placement of nozzles out on a boom might have a less variable swath and a lower drift potential. In addition, flying slower, using a relatively larger droplet VMD (i.e., 196 µm at ~207 kPa) may reduce both ground and airborne drift. This study may serve as a guideline for growers/operators to evaluate their UAAS platforms and optimize key attributes pertinent to UAAS operation for effective spraying.
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Ni, Xiaoqing, Yunjuan Gu, Haoyong Yu, Shenqi Wang, Ying Chen, Xinlei Wang, Xinlu Yuan, and Weiping Jia. "Serum Adipocyte Fatty Acid-Binding Protein 4 Levels Are Independently Associated with Radioisotope Glomerular Filtration Rate in Type 2 Diabetic Patients with Early Diabetic Nephropathy." BioMed Research International 2018 (May 27, 2018): 1–9. http://dx.doi.org/10.1155/2018/4578140.
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Serum fatty acid-binding protein 4 (FABP4) has been linked to renal dysfunction. This study evaluated the association between serum FABP4 and the radioisotope glomerular filtration rate (rGFR) in type 2 diabetic patients (T2DM) with early diabetic nephropathy. Twenty healthy controls and 172 patients with T2DM were enrolled. Serum FABP4 and renal impairment biomarkers including urinary albumin-to-creatinine ratio (UACR), serum retinal-binding protein 4 (RBP4), urinary cystatin C-to-creatinine ratio (CysC/Cr), and neutrophil gelatinase-associated lipocalin-to-creatinine ratio (NGAL/Cr) were measured. Diethylenetriaminepentaacetic acid (99mTc-DTPA) was used to test rGFR. Serum FABP4 levels were higher in T2DM patients compared with the controls. There was no significant correlation between serum FABP4 and UACR in patients with T2DM. Multivariate stepwise regression analysis showed that, in patients with T2DM, FABP4 was significantly associated with rGFR while CysC/Cr and RBP4 were significantly associated with UACR independently. But UACR had no independent association with rGFR. NGAL/Cr had no significant correlation with either rGFR or UACR. FABP4 might be an early biomarker for diabetic nephropathy if combined with UACR.
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Jardine, Meg, Zien Zhou, Hiddo J. Lambers Heerspink, Carinna Hockham, Qiang Li, Rajiv Agarwal, George L. Bakris, et al. "Kidney, Cardiovascular, and Safety Outcomes of Canagliflozin according to Baseline Albuminuria." Clinical Journal of the American Society of Nephrology 16, no. 3 (February 22, 2021): 384–95. http://dx.doi.org/10.2215/cjn.15260920.
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Background and objectivesThe kidney protective effects of renin-angiotensin system inhibitors are greater in people with higher levels of albuminuria at treatment initiation. Whether this applies to sodium-glucose cotransporter 2 (SGLT2) inhibitors is uncertain, particularly in patients with a very high urine albumin-to-creatinine ratio (UACR; ≥3000 mg/g). We examined the association between baseline UACR and the effects of the SGLT2 inhibitor, canagliflozin, on efficacy and safety outcomes in the Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) randomized controlled trial.Design, setting, participants, & measurementsThe study enrolled 4401 participants with type 2 diabetes, an eGFR of 30 to <90 ml/min per 1.73 m2, and UACR of >300 to 5000 mg/g. Using Cox proportional hazards regression, we examined the relative and absolute effects of canagliflozin on kidney, cardiovascular, and safety outcomes according to a baseline UACR of ≤1000 mg/g (n=2348), >1000 to <3000 mg/g (n=1547), and ≥3000 mg/g (n=506). In addition, we examined the effects of canagliflozin on UACR itself, eGFR slope, and the intermediate outcomes of glycated hemoglobin, body weight, and systolic BP.ResultsOverall, higher UACR was associated with higher rates of kidney and cardiovascular events. Canagliflozin reduced efficacy outcomes for all UACR levels, with no evidence that relative benefits varied between levels. For example, canagliflozin reduced the primary composite outcome by 24% (hazard ratio [HR], 0.76; 95% confidence interval [95% CI], 0.56 to 1.04) in the lowest UACR subgroup, 28% (HR, 0.72; 95% CI, 0.56 to 0.93) in the UACR subgroup >1000 to <3000 mg/g, and 37% (HR, 0.63; 95% CI, 0.47 to 0.84) in the highest subgroup (Pheterogeneity=0.55). Absolute risk reductions for kidney outcomes were greater in participants with higher baseline albuminuria; the number of primary composite events prevented across ascending UACR categories were 17 (95% CI, 3 to 38), 45 (95% CI, 9 to 81), and 119 (95% CI, 35 to 202) per 1000 treated participants over 2.6 years (Pheterogeneity=0.02). Rates of kidney-related adverse events were lower with canagliflozin, with a greater relative reduction in higher UACR categories.ConclusionsCanagliflozin safely reduces kidney and cardiovascular events in people with type 2 diabetes and severely increased albuminuria. In this population, the relative kidney benefits were consistent over a range of albuminuria levels, with greatest absolute kidney benefit in those with an UACR ≥3000 mg/g.Clinical Trial registry name and registration number:ClinicalTrials.gov: CREDENCE, NCT02065791.PodcastThis article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2021_02_22_CJN15260920_final.mp3
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Li, Li, Zhen Yu Fu, Tao Li, Jin Jun Liu, Zheng Yu Tian, and Guo Zheng Zhang. "Microstructure of Ti6Al4V after Ultrasound-Aided Deep Rolling." Advanced Materials Research 661 (February 2013): 141–44. http://dx.doi.org/10.4028/www.scientific.net/amr.661.141.
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Ti6Al4V titanium alloy was treated by an ultrasound-aided deep rolling (UADR) process. The microstructure of UADR treated specimen was observed via using scanning electron microscopy (SEM), X-ray diffraction (XRD) and transmission electron microscopy (TEM). Results show that ultrasound-aided deep rolling produced nanocrystallized microstructure of grain scale typically less than 20 nm on the immediate surface of Ti6Al4V. A nanometer to submicron gradient structured layer penetrating to a depth of about 150 μm was formed after UADR treatment. The above improvements of surface microstructure of the UADR treated specimen is believed to be beneficial to its anti-fatigue performance.
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Abbate, Manuela, Catalina M. Mascaró, Sofía Montemayor, María Barbería-Latasa, Miguel Casares, Cristina Gómez, Lucia Ugarriza, et al. "Animal Fat Intake Is Associated with Albuminuria in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome." Nutrients 13, no. 5 (May 4, 2021): 1548. http://dx.doi.org/10.3390/nu13051548.
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Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are associated with chronic kidney disease (CKD). Diet could play a predisposing role in the development of increased albuminuria in patients with NAFLD and MetS; however, published evidence is still limited. The aim of this cross-sectional analysis was to assess whether dietary fats are associated with changes in urinary albumin-to-creatinine ratio (UACR) in 146 patients aged 40–60-years with NAFLD and MetS. Dietary data were collected by food frequency questionnaire; UACR was measured in a single first morning void. Sources and types of dietary fats used in the analysis were total fat, fats from animal and vegetable sources, saturated, monounsaturated, polyunsaturated, and trans fats. One-way analysis of variance was performed to assess differences in dietary fats intakes across stages of UACR. The association between dietary fats and UACR was assessed by Pearson’s correlation coefficient and multivariable linear regression. Patients with increased UACR showed a worse cardiometabolic profile and higher intakes of animal fat, as compared to patients with normal levels of albuminuria. Animal fat intake was associated with mean UACR, independent of potential covariates.
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Lee, Joi, Chi Chu, David Guzman, Valy Fontil, Alexandra Velasquez, Neil R. Powe, and Delphine S. Tuot. "Albuminuria Testing by Race and Ethnicity among Patients with Hypertension with and without Diabetes." American Journal of Nephrology 50, no. 1 (2019): 48–54. http://dx.doi.org/10.1159/000500706.
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Background: Detection of chronic kidney disease (CKD) with urine albumin-to-creatinine ratio (UACR) among patients with hypertension (HTN) provides an opportunity for early treatment, potentially mitigating risk of CKD progression and cardiovascular complications. Differences in UACR testing patterns among racial/ethnic populations at risk for CKD could contribute to known disparities in CKD complications. Methods: We examined the prevalence of UACR testing among low-income adult primary care patients with HTN, defined by a new administrative code for HTN or 2 clinic blood pressures >140/90 mm Hg between January 1, 2014, and January 1, 2017, in one public health-care delivery system with a high prevalence of end-stage kidney disease among race/ethnic minorities. Logistic regression was used to identify odds of UACR testing within 1 year of a HTN diagnosis, overall, and by racial/ethnic subgroup, adjusted for demographic factors, estimated glomerular filtration rate, and HTN severity. Models were also stratified by diabetes status. Results: The cohort (n = 16,414) was racially/ethnically diverse (16% White, 21% Black, 34% Asian, 19% Hispanic, and 10% other) and 51% female. Only 35% of patients had UACR testing within 1 year of a HTN diagnosis. Among individuals without diabetes, odds of UACR testing were higher among Asians, Blacks, and Other subgroups compared to Whites (adjusted OR [aOR] 1.19; 95% CI 1.00–1.42 for Blacks; aOR 1.33; 1.13–1.56 for Asians; aOR 1.30; 1.04–1.60 for Other) but were not significantly different between Hispanics and Whites (aOR 1.17; 0.97–1.39). Among individuals with diabetes, only Asians had higher odds of UACR testing compared to Whites (aOR 1.35; 1.12–1.63). Conclusions: Prevalence of UACR testing among low-income patients with HTN is low in one public health-care delivery system, with higher odds of UACR testing among racial/ethnic minority subgroups compared to Whites without diabetes and similar odds among those with diabetes. If generalizable, less albuminuria testing may not explain higher prevalence of kidney failure in racial/ethnic minorities.
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Md Ershad, SK, Rafi Nazrul Islam, Mohammad Farhadul Haque, Shah Md Zakir Hossain, Md Zayeed Ahsan, Mohammad Syfur Rahman, Anirban Kishor Singha, Shahida Mullah, Asif Mahmud, and Md Rezaul Alam. "Differentiating glomerular from non-glomerular hematuria: role of urinary albumin-total protein ratio." BIRDEM Medical Journal 12, no. 1 (December 30, 2021): 51–56. http://dx.doi.org/10.3329/birdem.v12i1.57226.
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Background: Hematuria is one of the most common and early signs of diseases related to genitourinary system and can be classified as either glomerular or non-glomerular in origin. Percentage of dysmorphic RBC (%dRBC) in urine has been in practice as a diagnostic tool for differentiating glomerular from non-glomerular hematuria. Recent studies indicate that, urinary albumin-total protein ratio (uAPR) can also be used as a diagnostic tool in this regard. This study aimed to evaluate the sensitivity and specificity of uAPR as a diagnostic tool for detecting glomerular hematuria in comparison to %dRBC in urine. Methods: This cross-sectional study enrolled 96 patients with hematuria. Fresh urine samples were collected from each subject to determine the %dRBC and to calculate uAPR. Receiver operating characteristic curve analysis was done on these results to evaluate the sensitivity and specificity of uAPR and %dRBC in differentiating glomerular from non-glomerular hematuria. Results: uAPR and %dRBC were significantly (p<0.001) higher among patients with glomerular hematuria than non-glomerular hematuria. At the cutoff value of 0.57 mg/mg, uAPR showed sensitivity of 81.8% and specificity of 95.5%. At the cutoff value of 22.5%, %dRBC showed sensitivity of 54.5% and specificity of 86.4%. Conclusion: uAPR has higher sensitivity and specificity than %dRBC in differentiating glomerular from nonglomerular hematuria and can be used as a diagnostic tool. BIRDEM Med J 2022; 12(1): 51-56
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Fylypovych, Liudmyla O. "The history of UARR in memories." Ukrainian Religious Studies, no. 88 (September 24, 2019): 60–73. http://dx.doi.org/10.32420/2019.88.1402.
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By the anniversary of UARR, it was decided to collect the memories of the founders and active members of the association, for which the Questionnaire was developed, sending out to everyone who was somehow involved in the creation of this trade union. We have received some materials from leading religious scholars of Ukraine, whose publication we start with this issue. All respondents received the same questions, subjectively submitting their memories. Consider that more than a quarter of a century has passed since the creation of the UARR, something could be forgotten, something may be distorted, but these materials are of paramount importance as they tell the story of the first professional association of religious scholars in Ukraine, which is well known not only in Ukraine but also abroad.
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Hakroush, S., and B. Tampe. "AB0400 URINARY ALBUMIN-TO-CREATININE RATIO INDICATES NECROTIZING AND CRESCENTIC GLOMERULONEPHRITISIN ANCA-ASSOCIATED VASCULITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1228. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4298.
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Background:Renal involvement is a common and severe complication of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) as it can cause acute kidney injury (AKI), end-stage renal disease (ESRD) or death.Objectives:We have previously reported that elevated urinary albumin-to-creatinine ratio (uACR) correlates with rapid deterioration of kidney function in ANCA GN. Therefore, we here aimed to describe the association between proteinuric findings and histopathological diagnosis of necrotizing and crescentic ANCA GN in 50 urinary samples at admission and corresponding renal biopsies of patients with AAV.Methods:A total number of 50 urinary samples at admission and corresponding renal biopsies with confirmed renal involvement of AAV were retrospectively included between 2015 till 2020 in a single-center observational study.Results:Renal involvement of AAV revealed variable proteinuria ranging from low-range to nephrotic syndromes, however most patients presented with subnephrotic proteinuria. Severe deterioration of kidney function requiring RRT within 30 days after admission was associated with elevated levels of nonselective proteinuria, mostly attributed to albuminuria (uACR). Because we have previously shown that histologically confirmed ANCA GN with glomerular crescents and necrosis is associated with AKI and requirement of RRT during short-term disease course and elevated uACR levels were equally associated with AKI and requirement of RRT during the short-term course after disease onset, we next analyzed the association between uACR measurements at admission and histopathological findings within renal biopsies performed thereafter. Severely increased uACR levels >300 mg/g correlated with reduction of normal glomeruli, attributed to increased glomerular crescents and necrosis. By contrast, no such association was observed for global sclerotic glomeruli, revealing that uACR reflects crescentic ANCA GN rather than adaptive glomerular hyperfilitration in chronic sclerosing stage. Since uACR levels could reflect both, either a specific renal involvement with necrotizing and crescentic ANCA GN or severity of systemic AAV disease, we next correlated uACR levels assessed at admission with extrarenal disease manifestation. We observed no association between uACR levels and extrarenal manifestation of AAV disease including pulmonary hemorrhage, skin involvement and BVAS assessment, suggesting that uACR levels reflected specific renal involvement in AAV. These observations were further confirmed by survival analysis for cumulative incidence of RRT during the short-term course of disease.Conclusion:Early identification of patients who mostly benefit from aggressive immunosuppressive therapy is of clinical importance. Our observation that uACR levels at disease onset predict necrotizing and crescentic ANCA GN requires further investigation for therapeutic decision especially in patients with severe deterioration of kidney function.Disclosure of Interests:None declared
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Ganesan, Surendar, and Balasubramanian Esakki. "Computational fluid dynamic analysis of an unmanned amphibious aerial vehicle for drag reduction." International Journal of Intelligent Unmanned Systems 8, no. 3 (April 17, 2020): 187–200. http://dx.doi.org/10.1108/ijius-01-2019-0003.
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PurposeThe aim of this article is to minimize the drag of an unmanned amphibious aerial vehicle (UAAV) and enhancing the endurance.Design/methodology/approachVarious surface geometrical profiles such as rectangular, semicircular groove, razor blade and V-groove riblets are incorporated into the UAAV, and computational fluid dynamic (CFD) analysis is performed for various angles of attack at diverse vehicle speed conditions to estimate the coefficient of drag considering k–e turbulence model. Comparative evaluation between riblet and blunt body shape methodology is performed. Wind tunnel experiments are conducted to validate the flow characteristics around the UAAV.FindingsIt is observed that V-groove riblet method produced minimal drag in comparison with other profiles. The pressure distributions around UAAV for various geometrical profiles suggested that V-groove profile has achieved minimal vortex region, flow separation and turbulent boundary layer near to the outer profile.Originality/valueThe CFD analysis of UAAV for various riblet configurations and validation with wind tunnel smoke test confirms that UAAV with V-groove riblet provides low drag.
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Ha, Heebo, Yeongjae Seo, Paolo Matteini, Xue Qi, Sooman Lim, and Byungil Hwang. "Effect of a Urethane Acrylate-Based Photosensitive Coating on the Reliability of Ag Nanowire Transparent Electrodes." Applied Sciences 11, no. 5 (March 1, 2021): 2162. http://dx.doi.org/10.3390/app11052162.
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Due to the susceptibility of Ag nanowires to external mechanical and chemical damage, maintaining high optical performance and ambient and mechanical stability during the fabrication process is important for the industrial use of Ag nanowire transparent electrodes (TEs). In this study, urethane acrylate-based photosensitive resin (UAPR) is used as the coating material for Ag nanowire TEs to improve their optical transmittance, ambient stability, and resistance to external wiping damage. In the proposed method, UV-curable UAPR is coated onto Ag nanowire TEs using a simple doctor blade, forming a protective coating that increases the optical transmittance of the electrodes due to the refractive index of the UAPR between the air and the substrate. The UAPR coating successfully protects the Ag nanowires from corrosion in ambient air, with no significant change in their optical or electrical properties observed after 180 h of exposure to ambient air. Mechanical wiping tests also confirm that the UAPR coating is effective in protecting the Ag nanowires from external wiping damage, with no degradation of the optical or electrical properties observed after six wiping cycles.
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Wang, Dong-Dong, Cun Zhang, Yang Yang, Su-Mei He, Ping Zhu, and Xiao Chen. "Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Urine Albumin to Creatinine Ratio in Type 2 Diabetes Mellitus Patients and Medication Care." Journal of Diabetes Research 2022 (July 20, 2022): 1–8. http://dx.doi.org/10.1155/2022/5854200.
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Objectives. The purpose of this study was to explore the effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on urine albumin to creatinine ratio (UACR) in type 2 diabetes mellitus (T2DM) patients and to recommend appropriate medication care scheme. Methods. 8371 T2DM patients from four dapagliflozin studies and two canagliflozin studies were collected for analyzing with nonlinear mixed effect model (NONMEM). The change rates of UACR from baseline were intended to be evaluation indicators. Results. In the present study, there was no significant difference in the effects on UACR using dapagliflozin or canagliflozin treatment in T2DM patients. The maximal effect ( E max ) and the treatment duration of reaching half of E max (ET50) from SGLT-2 inhibitors on UACR in T2DM patients were -19.2% and 0.448 weeks, respectively. Further, the treatment duration to reach 25%, 50%, 75%, and 80% E max was 0.150 weeks, 0.448 weeks, 1.344 weeks, and 1.792 weeks, respectively. Namely, for achieving the plateau period (80% of E max ) of SGLT-2 inhibitors on UACR in T2DM patients, 10 mg/day dapagliflozin (or 100 mg/day canagliflozin) should be taken for at least 1.792 weeks. Conclusions. To our knowledge, the present study explored the effects of SGLT-2 inhibitors on UACR in T2DM patients, meanwhile, recommended appropriate medication care scheme for the first time.
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Na, Han, Rong Wang, Hai-Long Zheng, Xiao-Pan Chen, and Lin-Yang Zheng. "Correlation between Insulin Resistance and Microalbuminuria Creatinine Ratio in Postmenopausal Women." International Journal of Endocrinology 2022 (August 29, 2022): 1–6. http://dx.doi.org/10.1155/2022/9583611.
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Objective. To study the relationship between insulin resistance and urinary microalbumin creatinine ratio in postmenopausal women. Methods. The selected research group comprised 104 postmenopausal women with type 2 diabetes who were admitted to the Department of Endocrinology in the green card center at the First Affiliated Hospital of Hainan Medical University between 2017 and 2019 inclusive. Ninety-eight postmenopausal women with the normal blood glucose metabolism hospitalized in the same period were used as the control group. The age, body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, fasting blood glucose, fasting insulin (FINS), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and urinary albumin-creatinine ratio (UACR) were analyzed. The insulin resistance index (HOMR-IR) was calculated, and the correlation between IR and UACR was analyzed. Results. Levels of HOMA-IR, SBP, HbA1c, HDL-C, LDL-C, TC, TG, FPG, FINS, and UACR in the study group were higher than those in the control group, and a significant difference was found between the groups ( P < 0.05 ). The level of DBP in the study group was lower than that in the control group, and the difference was statistically significant ( P < 0.05 ). Pearson correlation analysis showed that UACR was positively correlated with HOMA-IR and HbA1c (r = 0.254, r = 0.565, P < 0.01 ). Multiple linear stepwise regression analysis further showed that HOMA-IR and age were positively correlated with UACR ( P < 0.05 ). Conclusion. There is a correlation between IR and UACR in postmenopausal women. IR is an independent risk factor for UACR.
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Oshima, Megumi, Tadashi Toyama, Akinori Hara, Miho Shimizu, Shinji Kitajima, Yasunori Iwata, Norihiko Sakai, et al. "Combined changes in albuminuria and kidney function and subsequent risk for kidney failure in type 2 diabetes." BMJ Open Diabetes Research & Care 9, no. 1 (June 2021): e002311. http://dx.doi.org/10.1136/bmjdrc-2021-002311.
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IntroductionChanges in albuminuria or estimated glomerular filtration rate (eGFR) can be used as a surrogate endpoint of end-stage kidney disease (ESKD) in people with type 2 diabetes. We investigated whether the combined changes in albuminuria and eGFR are more strongly associated with future risk of ESKD.Research design and methodsUsing data from a multicenter observational cohort study of people with type 2 diabetes, we evaluated the association of percentage change in urine albumin to creatinine ratio (UACR) and/or annual change in eGFR over 2 years with subsequent ESKD risk.ResultsAmong 1417 patients with repeated albuminuria and eGFR over 2 years, 129 (9.1%) developed ESKD. Patients with >30% UACR decline had lower ESKD risk (HR 0.47; 95% CI 0.29 to 0.77), whereas those with >30% UACR increase had higher ESKD risk (HR 2.31; 95% CI 1.52 to 3.51), compared with those with minor UACR change. Patients with greater eGFR decline had an increased ESKD risk than those with minor eGFR change (a decline of <2.5 mL/min/1.73 m2/year): HR 4.19 (95% CI 1.87 to 9.38) and 2.89 (95% CI 1.32 to 6.33) for those with a decline of >5 and 2.5–5 mL/min/1.73 m2/year, respectively. When the combined changes in UACR and eGFR were used, the highest ESKD risk (HR 5.60; 95% CI 2.08 to 15.09) was observed among patients with >30% UACR increase and an eGFR decline of >5 mL/min/1.73 m2/year compared with those with a minor change in UACR and eGFR.ConclusionsCombined changes in albuminuria and eGFR over 2 years were strongly associated with future risk of kidney failure in patients with type 2 diabetes.
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Mao, Wenfeng, Xinye Jin, Haibin Wang, Yingnan Ye, Linxi Zhang, Shi Gu, Jie Wang, Guang Ning, and Yiming Mu. "The Association between Resting Heart Rate and Urinary Albumin/Creatinine Ratio in Middle-Aged and Elderly Chinese Population: A Cross-Sectional Study." Journal of Diabetes Research 2019 (August 25, 2019): 1–7. http://dx.doi.org/10.1155/2019/9718370.
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Objective. In general population, resting heart rate (RHR) is associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relationship between RHR and urinary albumin/creatinine ratio (UACR, an indicator of early kidney injury) in general population at different levels of blood pressure and blood glucose. Methods. We screened out 32,885 subjects from the REACTION study after excluding the subjects with primary kidney disease, heart disease, tumor history, related drug application, and important data loss. The whole group was divided into four groups (Q1: RHR≤71, Q2: 72≤RHR≤78, Q3: 79≤RHR≤86, and Q4: 87≤RHR) according to the quartile of average resting heart rate. The renal function was evaluated by UACR (divided by quartiles of all data in the center to which the subject belonged). Ordinary logistic regression was carried out to explore the association between RHR and UACR at diverse blood pressure and blood glucose levels. Results. The subjects with higher RHR quartile tend to have a higher UACR, even multifactors were adjusted. After stratifying the subjects according to blood pressure and blood glucose, the positive relationship between RHR and UACR remained in the subjects with normal blood pressure and normal glucose tolerance, while in the hypertension (SBP≥140 mmHg and/or DBP≥90 mmHg) group and the diabetic mellitus (FPG≥7.0 mmol/L and/or PPG≥11.1 mmol/L) group, the relationship disappeared. In the subjects without hypertension, compared with the Q1 group, the UACR is significant higher in the Q3 group (OR: 1.11) and the Q4 group (OR: 1.22). In the subjects with normal glucose tolerance (NGT), compared with the Q1 group, the UACR is significantly higher in the Q3 group (OR: 1.13) and the Q4 group (OR: 1.19). Conclusions. The population with higher RHR tend to have a higher UACR in the normal blood pressure group and the normal glucose tolerance group.
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Jukes, T. H., S. Osawa, and Patrick J. Keeling. "UAR Codons for Glutamine." Journal of Molecular Evolution 45, no. 3 (September 1997): 207–8. http://dx.doi.org/10.1007/pl00022753.
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Vital Caballero, Aidé Trinidad, and Patricia Villalpando Salas. "Proyectos de innovación UAA." DOCERE, no. 1 (October 30, 2009): 10–14. http://dx.doi.org/10.33064/2009docere12459.
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Gudyma, A. "Ternopil branch of UAR." Ukrainian Religious Studies, no. 1 (March 31, 1996): 61–62. http://dx.doi.org/10.32420/1996.1.29.
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Zhuang, Xuenan, Dan Cao, Dawei Yang, Yunkao Zeng, Honghua Yu, Jun Wang, Jian Kuang, Jianteng Xie, Shuting Zhang, and Liang Zhang. "Association of diabetic retinopathy and diabetic macular oedema with renal function in southern Chinese patients with type 2 diabetes mellitus: a single-centre observational study." BMJ Open 9, no. 9 (September 2019): e031194. http://dx.doi.org/10.1136/bmjopen-2019-031194.
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Background and objectivesThe association of diabetic retinopathy (DR) and diabetic macular oedema (DME) with renal function in southern Chinese patients with diabetes is poorly understood. So we aimed to study the correlation between stage of DR and DME with stage of estimated glomerular filtration rate (eGFR) and stage of urine albumin-to-creatinine ratio (UACR), and to explore the systemic risk factors for DR and DME.Design and settingThis single-centre retrospective observational study was conducted from December 2017 to November 2018.Participants413 southern Chinese patients with type 2 diabetes mellitus.Outcome measuresThe correlations between stage of DR and DME with stage of eGFR/UACR were assessed by Spearman’s or χ² analyses and represented with histograms. Risk factors associated with the occurrence of DR and DME were performed by logistic regression and represented with nomograms.ResultsStage of DR had a positive correlation with stage of eGFR (r=0.264, p<0.001) and stage of UACR (r=0.542, p<0.001). With the stage of eGFR/UACR being more severe, the prevalence of DME became higher as well (both p<0.001). The risk factors for DR were DM duration (OR 1.072; 95% CI 1.032 to 1.114; p<0.001), stage of UACR (OR 2.001; 95% CI 1.567 to 2.555; p<0.001) and low-density lipoprotein (LDL) (OR 1.301; 95% CI 1.139 to 1.485; p<0.001), while risk factors for DME were stage of UACR (OR 2.308; 95% CI 1.815 to 2.934; p<0.001) and LDL (OR 1.460; 95% CI 1.123 to 1.875; p=0.008).ConclusionsAmong southern Chinese patients, stage of DR and DME were positively correlated with renal function, while stage of UACR performed a better relevance than stage of eGFR.