Dissertations / Theses on the topic 'Tumour associated carbohydrate'
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Youakim, Adel. "Tumour- and differentiation-associated changes in the carbohydrate structure of glycoproteins from human colonic cells." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75826.
Full textDifferentiation of CaCo-2 cells to polarized cells containing brush border enzymes characteristic of enterocytes is accompanied by a decrease in the relative proportion of fucose- and glucosamine-labeled N-linked polylactosaminoglycans-containing glycopeptides. These polylactosaminoglycans are found on a restricted set of glycoproteins of M$ sb{ rm r}$ 100,000-130,000. In undifferentiated cells, these glycoproteins contain a greater proportion of polylactosaminoglycans than those from differentiated cells.
Shi, Mengchao. "Design and Synthesis of a Novel Entirely Carbohydrate-Based Conjugate for Cancer Vaccine Development." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470412718.
Full textKleski, Kristopher A. "Progress of Entirely Carbohydrate Conjugates in Cancer Immunotherapeutics – Syntheses and Developments." University of Toledo / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1586980386810219.
Full textTrabbic, Kevin R. "Approaches to Increase the Immunogenicity of Carbohydrate Antigens Using PS A1 and Subsequent Immunotherapies." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470330973.
Full textYamazaki, Yuji. "Investigation on Chemical and Enzymatic Synthesis of Tumor Associated Carbohydrate Antigens Triggering Immune Responses." Kyoto University, 2019. http://hdl.handle.net/2433/242472.
Full textZou, Jun. "Characterization of peptides and phage that bind galectin-3 selected from bacteriophage display libraries a study of the role of galectin-3 in metastasis-associated cancer cell adhesion /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4149.
Full text"December 2005" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.
LIU, SI-XIAN, and 劉思嫺. "Preparation of Carbohydrate Polymers Containing Three Different Tumor-Associated Carbohydrate Antigens." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/2sgct7.
Full text輔仁大學
化學系
107
Preparation of styrene-type glycoconjugates monomers, containing tumor-associated carbohydrate antigens (TACAs), such as Tn (Ser- / Thr- type), TF and sTn were developed. Polymerization of these TACAs monomers with polystyrene framework by NMP (Nitroxide-mediated radical polymerization) were also studied. Tn antigens were synthesized by the glycosylation reactions of D-galactose derivative, as glycol donor and L-serine or L-threonine derivatives as glycol acceptors. The first glycosylation reaction was proceeded to get the glycoproteins building blocks. The α-anomer was separated, and then attached to styrene through a spacer of diethylene glycol amine. The Tn glycoconjugate monomers were polymerized successfully to afford Tn glycoconjugate glycopolymers. To prepare others antigens, several functional groups were protected. Attachments of the second carbohydrate moieties, such as D-galatose and sialic acid, were constructed by the second glycosylation reactions. These two antigens were synthesized by the same methods used in the synthesis of Tn monomers, and eventually afforded three different types of glycoconjugates monomers. Controlled living radical polymerization (CLRP) of these three Tn glycoconjugate monomers were studied to produce the random and block co-polymers. Resulting glycopolymers were analyzed by NMR and ATR-IR to confirm TACAs presented on the polystyrene backbone.
Jan, Fan-Dan, and 詹凡丹. "Synthese and Immunogenicities of Tumor-Associated Carbohydrate Vaccines." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/02685009606746575616.
Full textHuang, Yu-Ching, and 黃郁清. "Synthesis of S-Linked GD3 Tumor-Associated Carbohydrate Antigen." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/92445270678667358695.
Full textLeClair, Christopher Arthur. "Advances towards synthesis of C-glycosyl tumor-associated carbohydrate antigens /." 2006. http://wwwlib.umi.com/dissertations/fullcit/3225946.
Full textTSAI, YUN-TZU, and 蔡芸慈. "Preparation of Glycopolymers Containing Tumor-associated Carbohydrate Antigens by Nitroxide-Mediated Polymerization." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/d54gk9.
Full text輔仁大學
化學系
106
Starting from D-galactose, the glycosyl donor was prepared within 4 steps. In contrast, the glycosyl acceptor consisting of diethylene glycol and styrene to carry out the glycosylation reaction. After the product is obtained, the azide group is converted into an NHAc group to obtain a glycolmonomer, and a different sugar ratio polymer is prepared by using the NMP polymerization. On the other hand, in order to synthesize a product that is closer to a authentic structures of Tn antigens, benzyl group was first protected by Fmoc-Ser- OH as an starting material on the carboxylic acid, followed by the glycosylation reaction with a glycosyl donor, then coupled with a spacer to obtain a Tn-containing glycolmonomer for polymerization. From the experimental results, it is inferred that the Fmoc protecting group may be cleaved at a high temperature for a long time, causing difficulty in the polymerization reaction. In order to improve this situation, we converted its protecting group to acetyl group to obtain a sugar monomer for NMP reaction. Currently, all glycolpolymers can be confirmed by 1H NMR and IR spectra. This study provides the first synthesis method for the preparation of Tn glycolmonomer, and is the first ever to produce Tn-containing glycolmonomer by NMP reaction.
Li, Yanhong. "Towards fully synthetic anticancer vaccines synthesis of tumor associated carbohydrate antigens and development of carbohydrate-based anticancer vaccines /." 2004. http://purl.galileo.usg.edu/uga%5Fetd/li%5Fyanhong%5F200405%5Fphd.
Full textChuang, Hong-Yang, and 莊宏揚. "Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/89939994362828728549.
Full text國立臺灣大學
化學研究所
102
Prostate cancer is the most commonly diagnosed cancer among men and the RM2 antigen has been discovered as a member of an antigenic carbohydrates family that is highly expressed on prostate cancer cells. The novel antigen RM2 belongs to ‘‘ganglio-series’’and the ‘‘disialyl lacto-series type chain’’ groups. And the RM2 antigen was not been synthesized by chemical method before. In this thesis, we have successfully developed a [1+2+3] one-pot strategy to synthesize the RM2 antigen hexasaccharide that was proposed to be a prostate tumor antigen. The structure of the synthetic product was verified by NMR analysis and antibody binding assay using a glycan microarray. In addition, the synthetic antigen was conjugated to a mutated diphtheria toxin (DT, CRM197) with different copy numbers and adjuvant combination to form the vaccine candidates. After vaccination in mice, we used glycan microarrays to monitor their immune response, and the results indicated that when one molecule of DT was incorporated with 4.7 molecules of RM2 in average (DT-RM4.7) and adjuvanted with the glycolipid C34 exhibited the strongest anti-RM2 IgG titer. Moreover, the induced mouse antibodies mediated effective complement-dependent cytotoxicity (CDC) against the prostate cancer cell line LNCap.
Grosso, Ana Sofia de Campos. "Molecular recognition of tumor-associated antigens by lectins and antibodies." Master's thesis, 2017. http://hdl.handle.net/10362/26262.
Full textMickael, Guillemineau. "Total Synthesis of the Tumor-Associated Carbohydrate Antigen Lewis A Lewis X Hexasaccharide and Selected Fragments." Thesis, 2012. http://hdl.handle.net/10214/3847.
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