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Journal articles on the topic 'Tumour active'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Keln, A. A., S. S. Schmidt, A. V. Kupchin, and B. A. Berdichevsky. "Active monitoring of contrast-accumulating kidney tumours." Urology Herald 8, no. 4 (2020): 53–61. http://dx.doi.org/10.21886/2308-6424-2020-8-4-53-61.

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Introduction. The incidence of kidney cancer (KC) in the world is increasing and today is about 3%, but the death rate from this type of malignancy does not increase proportionally. According to research by many authors, more than half of the patients are over 65 years old at the time of diagnosis. Patients at this age have a high incidence of high comorbidity and risk of death from cardiovascular or other intercurrent pathology that exceeds the risk of death from KC. Recently, there has been a positive trend in the detection of the disease in the early stages up to 61.80%. Most of the primary

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2

&NA;. "Tumour-specific superantigens - super active." Inpharma Weekly &NA;, no. 896 (1993): 12. http://dx.doi.org/10.2165/00128413-199308960-00026.

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3

Sagnella, Sharon M., Joshua A. McCarroll, and Maria Kavallaris. "Drug delivery: Beyond active tumour targeting." Nanomedicine: Nanotechnology, Biology and Medicine 10, no. 6 (2014): 1131–37. http://dx.doi.org/10.1016/j.nano.2014.04.012.

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4

Bucella, Dario, Jean-Frédéric Limbosch, Frédéric Buxant, et al. "Recurrence of Mitotically Active Cellular Fibroma of the Ovary." Obstetrics and Gynecology International 2009 (2009): 1–3. http://dx.doi.org/10.1155/2009/803062.

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Background. 10% of ovarian fibromatous tumours typically exhibit increased cellularity, mitotic activity, and less frequently nuclear atypia. Therefore, the classification within the group of fibromatous tumours may represent some difficulties, thus, one or several of these features should appear.Case. We introduce the clinical and pathologic features based on one case of recurrence of a mitotically active cellular ovarian fibroma (MACF) in the pararectal fossa. This recurrence took place six years after primary surgery. Macroscopically, the tumour was firm, fibrous, well delimited, yellow-whi

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Shankar Dey, Bhabani, Manas Kumar Bera, and Binoy Krishna Roy. "Nonlinear active control of a cancerous tumour." International Journal of Engineering & Technology 7, no. 2.21 (2018): 72. http://dx.doi.org/10.14419/ijet.v7i2.21.11839.

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This paper deals with the control of a cancerous tumour growth. The model used is a Three-Dimensional Cancer Model (TDCM). The competition terms include tumour cells, healthy cells, and immune cells. Nature of the competition among the populations of tumour cells, healthy host cells, and immune cells results in a chaotic behaviour. In this paper, a nonlinear active control has been used to control the growth of a tumour. Effect of chemotherapy drug on the different cell populations has been studied. Our control objective is to control the tumour growth and minimize its population to a small va

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Hirsjarvi, Samuli, Catherine Passirani, and Jean-Pierre Benoit. "Passive and Active Tumour Targeting with Nanocarriers." Current Drug Discovery Technologies 8, no. 3 (2011): 188–96. http://dx.doi.org/10.2174/157016311796798991.

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7

Salmaso, Stefano, Sara Bersani, Alessandra Semenzato, and Paolo Caliceti. "New cyclodextrin bioconjugates for active tumour targeting." Journal of Drug Targeting 15, no. 6 (2007): 379–90. http://dx.doi.org/10.1080/10611860701349752.

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8

Yan, Hengkang, Mary E. Vail, Linda Hii, et al. "Preferential Antibody and Drug Conjugate Targeting of the ADAM10 Metalloprotease in Tumours." Cancers 14, no. 13 (2022): 3171. http://dx.doi.org/10.3390/cancers14133171.

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ADAM10 is a transmembrane metalloprotease that sheds a variety of cell surface proteins, including receptors and ligands that regulate a range of developmental processes which re-emerge during tumour development. While ADAM10 is ubiquitously expressed, its activity is normally tightly regulated, but becomes deregulated in tumours. We previously reported the generation of a monoclonal antibody, 8C7, which preferentially recognises an active form of ADAM10 in human and mouse tumours. We now report our investigation of the mechanism of this specificity, and the preferential targeting of 8C7 to hu

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9

O'Rourke, N. P., E. V. McCloskey, and J. A. Kanis. "Tumour induced hypercalcaemia: A case for active treatment." Clinical Oncology 6, no. 3 (1994): 172–76. http://dx.doi.org/10.1016/s0936-6555(94)80057-x.

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10

Herrmann, Th. "Radiation oncology and functional imaging." Nuklearmedizin 44, S 01 (2005): S38—S40. http://dx.doi.org/10.1055/s-0038-1625213.

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Summary:PET/CT imaging is most likely to be of use in radiation oncology with patients who have poorly defined target volume areas, e.g. brain tumours, bronchogenic carcinoma, and cases of miscellaneous geographical miss. Other tumours that call for dose escalated radiotherapy, such as head and neck tumours, bronchogenic carcinoma, and prostate carcinomas may further benefit from an accurate delineation of the metabolically active tumour volume and its differentiation from surrounding healthy tissue, or tumour atelectasis.

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11

Bogdan, Michał J., and Thierry Savin. "Fingering instabilities in tissue invasion: an active fluid model." Royal Society Open Science 5, no. 12 (2018): 181579. http://dx.doi.org/10.1098/rsos.181579.

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Metastatic tumours often invade healthy neighbouring tissues by forming multicellular finger-like protrusions emerging from the cancer mass. To understand the mechanical context behind this phenomenon, we here develop a minimalist fluid model of a self-propelled, growing biological tissue. The theory involves only four mechanical parameters and remains analytically trackable in various settings. As an application of the model, we study the evolution of a two-dimensional circular droplet made of our active and expanding fluid, and embedded in a passive non-growing tissue. This system could be u

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12

Calvio, L., M. Feuerstein, J. Hansen, and G. M. Luff. "Cognitive limitations in occupationally active malignant brain tumour survivors." Occupational Medicine 59, no. 6 (2009): 406–12. http://dx.doi.org/10.1093/occmed/kqp094.

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13

Gielen, Marcel, Abdelaziz El Khloufi, Monique Biesemans, et al. "Synthesis, Characterization and High In Vitro Antitumour Activity of Novel Triphenyltin Carboxylates." Metal-Based Drugs 1, no. 4 (1994): 305–9. http://dx.doi.org/10.1155/mbd.1994.305.

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The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7.

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14

Rahman, Muhammad M., Dimalee Herath, John C. Bladen, et al. "Differential expression of phosphorylated MEK and ERK correlates with aggressive BCC subtypes." Carcinogenesis 42, no. 7 (2021): 975–83. http://dx.doi.org/10.1093/carcin/bgab036.

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Abstract Basal cell carcinoma (BCC) is associated with aberrant Hedgehog (HH) signalling through mutational inactivation of PTCH1; however, there is conflicting data regarding MEK/ERK signalling in BCC and the signalling pathway interactions in these carcinomas. To address this, expression of active phospho (p) MEK and ERK was examined in a panel of 15 non-aggressive and 14 aggressive BCCs. Although not uniformly expressed, both phospho-proteins were detected in the nuclei and/or cytoplasm of normal and tumour-associated epidermal cells however, whereas phospho-MEK (pMEK) was present in all no

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15

Kumar, Vikas. "Segmentation of Brain Images by Optimizing Clustering of Convolution Based Features." E3S Web of Conferences 229 (2021): 01034. http://dx.doi.org/10.1051/e3sconf/202122901034.

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Brain tumour segmentation aims to separate the various types of tumour tissues like active cells, necrotic core, and edema from normal brain tissues of substantia alba (WM), grey matter (GM), and spinal fluid (CSF). Magnetic Resonance Imaging based brain tumour segmentation studies are attracting more and more attention in recent years thanks to non-invasive imaging and good soft tissue contrast of resonance Imaging (MRI) images. With the event of just about two decades, the ingenious approaches applying computer-aided techniques for segmenting brain tumour are getting more and more mature and

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Nowakowska, Anna, and Jolanta Tarasiuk. "Invasion and metastasis of tumour cells resistant to chemotherapy." Postępy Higieny i Medycyny Doświadczalnej 71, no. 1 (2017): 0. http://dx.doi.org/10.5604/01.3001.0010.3822.

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Metastatic tumours resistant to chemotherapy are the major cause of the clinical failure in the treatment of malignant diseases. It is observed often that drugs active against primary tumours do not exhibit the same efficacy towards metastatic tumour cells having modified signaling pathways. Among cellular factors involved in the development of the metastatic potential of multidrug resistant tumour cells are some oncoproteins, antiapoptotic proteins, mutated suppressor proteins, integrins and CD44 receptor. It was also demonstrated that numerous chemotherapeutics have the effect on the emergen

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17

Kwan, Amy, Faith Howard, Natalie Winder, et al. "Macrophage Delivered HSV1716 Is Active against Triple Negative Breast Cancer." Future Pharmacology 2, no. 4 (2022): 444–59. http://dx.doi.org/10.3390/futurepharmacol2040029.

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Oncolytic viruses (OV) promote anti-tumour responses through the initiation of immunogenic cancer cell death which activates the host’s systemic anti-tumour immunity. We have previously shown that intravenously administered HSV1716 is an effective treatment for mammary cancer. However, intravenous administration of a virus has the potential to result in neutralization and sequestration of the virus which may reduce efficacy. Here, we show that the oncolytic virus HSV1716 can be administered within a cellular carrier (macrophages). PyMT and 4T1 murine mammary cancer cell lines were implanted in

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18

Peng, Xiang, Jinchao Chen, Jiangyi Wang, et al. "Natural history of renal tumours in von Hippel-Lindau disease: a large retrospective study of Chinese patients." Journal of Medical Genetics 56, no. 6 (2019): 380–87. http://dx.doi.org/10.1136/jmedgenet-2018-105567.

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BackgroundHistorically, renal cell carcinoma (RCC) is one of the main causes of death in von Hippel-Lindau (VHL) disease. However, the natural history of VHL-related RCC has not been thoroughly elucidated to date. This report described the natural history of VHL-related RCC in a large Chinese VHL cohort and might be helpful in the surveillance and treatment of VHL disease.MethodsIn this retrospective study, we included 196 renal tumours from 150 patients with VHL disease. Statistical analysis was used to evaluate the influence of age of onset, sex, family history, unilateral or bilateral tumou

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19

Casellas, F., M. Papo, F. Guarner, M. Antolín, J. R. Armengol, and J. R. Malagelada. "Intraluminal Colonic Release of Immunoreactive Tumour Necrosis Factor in Chronic Ulcerative Colitis." Clinical Science 87, no. 4 (1994): 453–58. http://dx.doi.org/10.1042/cs0870453.

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1. Tumour necrosis factor is a proinflammatory macrophage-derived polypeptide cytokine. Its participation in disease processes has been usually inferred from data obtained from experiments in vitro or from measurements of its plasma circulating levels. To investigate its role in chronic ulcerative colitis, we have quantified in vivo the steady-state release of tumour necrosis factor into the colonic lumen. 2. We studied 19 patients with untreated active ulcerative colitis and seven patients with irritable bowel syndrome as controls. A group of seven patients with active ulcerative colitis were

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Muller, Catherine. "Tumour-surrounding adipocytes are active players in breast cancer progression." Annales d'Endocrinologie 74, no. 2 (2013): 108–10. http://dx.doi.org/10.1016/j.ando.2013.02.007.

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21

Peters, MA, FH de Jong, KJ Teerds, DG de Rooij, SJ Dieleman, and FJ van Sluijs. "Ageing, testicular tumours and the pituitary-testis axis in dogs." Journal of Endocrinology 166, no. 1 (2000): 153–61. http://dx.doi.org/10.1677/joe.0.1660153.

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Dogs of different ages without testicular diseases were evaluated to study possible age-related changes in hormone concentrations in serum. Dogs with testicular tumours were also investigated to study the relation between tumour type and hormone concentrations; in this study, dogs with Sertoli cell tumours, Leydig cell tumours and seminomas were included. We measured testosterone, oestradiol, LH, FSH and inhibin-like immunoreactivity concentrations in peripheral venous and testicular venous blood of these animals. In normal dogs there appeared to be no age-related changes in the concentrations

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22

Hadebe, Bawinile, Machaba Michael Sathekge, Colleen Aldous, and Mariza Vorster. "Current Status of 68Ga-Pentixafor in Solid Tumours." Diagnostics 12, no. 9 (2022): 2135. http://dx.doi.org/10.3390/diagnostics12092135.

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Chemokine receptor CXCR4 is overexpressed in neoplasms and its expression is related to tumour invasion, metastasis and aggressiveness. 68Ga-Pentixafor is used to non-invasively image the expression of CXCR4 in tumours and has been widely used in haematological malignancies. Recent evidence shows that therapies targeting CXCR4 can increase the chemosensitivity of the tumour as well as inhibit tumour metastasis and aggressiveness. 68Ga-Pentixafor has shown promise as an elegant radiotracer to aid in the selection of patients whose tumours demonstrate CXCR4 overexpression and who therefore may b

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23

Newlands, E. S., L. Holden, and K. D. Bagshawe. "Tumour Markers and POMB/ACE Chemotherapy in the Management of Ovarian Germ Cell Tumours (GCTs)." International Journal of Biological Markers 3, no. 3 (1988): 185–92. http://dx.doi.org/10.1177/172460088800300307.

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The management of ovarian germ cell tumours (GCTs) has changed dramatically over the last 15 years. The combination of the introduction of tumour markers which accurately monitor the behaviour of the majority of germ cell tumours together with the introduction of newer chemotherapeutic agents has meant that few patients even with metastases should succumb from their disease. The tumour markers, human chorionic gonadotrophin (hCG) and alpha-foetoprotein (AFP) and, to a lesser extent, lactate dehydrogenase (LDH) and placental alkaline phosphatase (PLAP) are routinely used in assisting diagnosis,

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Setyono-Han, Buddy, Jörg Stürzebecher, Wolfgang Schmalix, et al. "Suppression of rat breast cancer metastasis and reduction of primary tumour growth by the small synthetic urokinase inhibitor WX-UK1." Thrombosis and Haemostasis 93, no. 04 (2005): 779–86. http://dx.doi.org/10.1160/th04-11-0712.

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SummaryThe serine protease uPA (urokinase-type plasminogen activator) and its receptor uPAR (CD87) are often elevated in malignant tumours, hence, inhibition of this tumour-associated plasminogen activation system provides an attractive target for therapeutic strategies. WX-UK1, a derivative of 3-aminophenylalanine in the L-conformation with inhibitory antiproteolytic properties, was tested for its specificity spectrum using specific chromogenic paranitroanilide peptide substrates. The corresponding D-enantiomer of WX-UK1 was used as a control. The anti-tumour and anti-metastatic (number of lu

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Raehaan, Nur Rahmi, Asvin Nurulita, and Mansyur Arif. "CARCInoeMBRYonIC AnTIGen (CEA) DI KANKER KOLOREKTAL." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 20, no. 3 (2016): 192. http://dx.doi.org/10.24293/ijcpml.v20i3.465.

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Colorectal cancer is a common gastrointestinal malignancy of the colon and rectum. According to the American Society of Clinical Oncology (ASCO) in 2006, preoperative CEA level is useful in dtermining the tumour stage, plan of action and monitoring therapeutic response during the active treatment. Several factors which influence CEA level in patients with colorectal cancer is the staging and the degree of tumour, liver function, and as well as its location. This retrospective study is aimed to know the preoperative CEA levels in 51 patients with colorectal cancer and to compare the levels of C

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Ewing, Ailith, and Colin Semple. "Breaking point: the genesis and impact of structural variation in tumours." F1000Research 7 (November 19, 2018): 1814. http://dx.doi.org/10.12688/f1000research.16079.1.

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Somatic structural variants undoubtedly play important roles in driving tumourigenesis. This is evident despite the substantial technical challenges that remain in accurately detecting structural variants and their breakpoints in tumours and in spite of our incomplete understanding of the impact of structural variants on cellular function. Developments in these areas of research contribute to the ongoing discovery of structural variation with a clear impact on the evolution of the tumour and on the clinical importance to the patient. Recent large whole genome sequencing studies have reinforced

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Gupta, M., S. K. Sharma, R. Saxena, and S. Arora. "Analysis of machine learning algorithms in brain tumour prediction." Journal of Physics: Conference Series 2070, no. 1 (2021): 012090. http://dx.doi.org/10.1088/1742-6596/2070/1/012090.

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Abstract The tumour is fundamentally an excessive development of dangerous cells in any part of the body, while a tumour in a brain is an unreasonable development of cancerous cells in the brain. Brain tumour can be either benign or malignant. The benign brain tumour has structural consistency and does not include active (cancer) cells, but the malignant brain tumour has no structure consistency and includes active cells. The primary concern is to segment, detect, and extract the infected tumour area from magnetic resonance images (MRI) which are being performed by radiologists or medical expe

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Eftimie, R., and L. Gibelli. "A kinetic theory approach for modelling tumour and macrophages heterogeneity and plasticity during cancer progression." Mathematical Models and Methods in Applied Sciences 30, no. 04 (2020): 659–83. http://dx.doi.org/10.1142/s0218202520400011.

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The heterogeneity and plasticity of macrophages have become a topic of great interest, due to their role in various diseases ranging from cancer to bacterial infections. While initial experimental studies assumed an extreme polarisation situation, with the (anti-tumour) M1 and (pro-tumour) M2 macrophages representing the two extreme cell phenotypes, more recent studies showed a continuum of macrophages polarisation phenotypes. Here, we focus on tumour-macrophage interactions and develop a mathematical model based on kinetic equations for active particles to describe (i) the dynamics of macroph

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Yacyshyn, BR, BM Longenecker, WA Biermann, D. McClure, S. Poppema, and MB Bowen-Yacyshyn. "Active Specific Immunotherapy in the Management of Adenocarcinoma of the Pancreas." Canadian Journal of Gastroenterology 9, no. 4 (1995): 213–16. http://dx.doi.org/10.1155/1995/491787.

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Active specific immunotherapy for pancreatic adenocarcinoma and subsequent immunohistochemical analysis of tumour tissue have not been previously reported. To date, the therapy of pancreatic adenocarcinoma has been largely unsuccessful. A patient treated with a therapeutic ‘cancer vaccine’ and the immunological impact on the primary tumour of this potential new therapy are described. To the authors’ knowledge, this is both the first patient to be treated with active specific immunotherapy for pancreatic adenocarcinoma and the first to be studied immunologically by flow cytometry and immunohist

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Alam, Md Nur, and Fazlul Huq. "Comprehensive review on tumour active palladium compounds and structure–activity relationships." Coordination Chemistry Reviews 316 (June 2016): 36–67. http://dx.doi.org/10.1016/j.ccr.2016.02.001.

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31

Vauleon, Elodie, Tony Avril, Brigitte Collet, Jean Mosser, and Véronique Quillien. "Overview of Cellular Immunotherapy for Patients with Glioblastoma." Clinical and Developmental Immunology 2010 (2010): 1–18. http://dx.doi.org/10.1155/2010/689171.

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High grade gliomas (HGG) including glioblastomas (GBM) are the most common and devastating primary brain tumours. Despite important progresses in GBM treatment that currently includes surgery combined to radio- and chemotherapy, GBM patients' prognosis remains very poor. Immunotherapy is one of the new promising therapeutic approaches that can specifically target tumour cells. Such an approach could also maintain long term antitumour responses without inducing neurologic defects. Since the past 25 years, adoptive and active immunotherapies using lymphokine-activated killer cells, cytotoxic T c

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Real, Carla, Francisco Caiado, Catia Igreja, et al. "Delta Like 4 Expressing Bone Marrow-Derived Endothelial Progenitor Cells Regulate Tumour Angiogenesis." Blood 110, no. 11 (2007): 3728. http://dx.doi.org/10.1182/blood.v110.11.3728.3728.

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Abstract Bone marrow-derived endothelial progenitor cells (BM-EPCs) have been implicated in adult neoangiogenesis and consequently used as therapies for human pathologies with endothelial damage. The administration of these cells in human patients temporally improves endothelial function, although the engraftment of these cells in newly formed vessels is inefficient. Conversely, therapeutic stratagies to block EPC contribution during tumor angiogenesis have been proposed. In this work, we analysed the role of the Notch/Delta signalling pathway in EPC function during tumour neoangiogenesis, by

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Szostek, Arnika, Jakub Wydra, Izabella Czajka-Oraniec, and Wojciech Zgliczyński. "Two successful pregnancies in a woman with active acromegaly." Wiedza Medyczna 2, no. 2 (2020): 72–76. http://dx.doi.org/10.36553/wm.60.

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Acromegaly is a rare systemic disease, predominantly caused by growth hormone (GH)-secreting pituitary adenoma, leading to insulin-like growth factor-1 (IGF-1) overproduction. Pituitary adenoma extension and/or its treatment can cause infertility or subfertility in both sexes in different mechanisms. Pregnancies in women with active acromegaly are rarely observed but considered generally safe. Growth hormone and IGF-1 concentrations are usually stable during pregnancy and in most cases no significant tumour expansion emerges despite pharmacological therapy withdrawal. A 28 year-old woman

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Hayes, James R., Michael A. S. Jewett, and Robert J. Hamilton. "28-year late spermatic cord relapse of a testicular non-seminomatous germ cell tumour, managed robotically." Canadian Urological Association Journal 10, no. 7-8 (2016): 257. http://dx.doi.org/10.5489/cuaj.3492.

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We present a patient who relapsed symptomatically 28 years postorchiectomy, initially followed by active surveillance for clinical stage I non-seminomatous germ cell tumour (CSI NSGCT). His relapse was localized to the pelvis, managed with robotic surgery, and achieved a complete resection with tumour markers normalized. We highlight the current Princess Margaret guidelines for followup of CSI NSGCT and discuss the trade-off between lifelong radiographic surveillance to detect the very small risk of late relapse. We discuss the incidence and presentation of late relapse, treatment options, and

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Plank, M. J., and B. D. Sleeman. "Tumour-Induced Angiogenesis: A Review." Journal of Theoretical Medicine 5, no. 3-4 (2003): 137–53. http://dx.doi.org/10.1080/10273360410001700843.

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Angiogenesis, the formation of new blood vessels, has become a broad subject and is a very active area for current research. This paper describes the main biological events involved in angiogenesis and their importance in cancer progression. In the first section, a fundamental overview of tumour biology is presented. In the second section, the biology of healthy blood vessels is described and, in the third section, the mechanisms of cell migration and proliferation, which are crucial to angiogenesis, are discussed. In the fourth section, a detailed account of tumour-induced angiogenesis is giv

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R. I. O., Nwoha, Onyegbula O., and Daniel G. I. "Treatment and Regression of Transmissible Venearal Tumour in Dogs." Sumerianz Journal of Agriculture and Veterinary, no. 43 (September 16, 2021): 92–96. http://dx.doi.org/10.47752/sjav.43.92.96.

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Antimicrobial resistance threatens the effective treatment of vast range of bacterial, fungi and viral diseases. Transmissible venereal tumour (TVT) is one of the highly contagious tumour in dogs commonly affecting sexually active stud and bitches. The disease was observed in a male and female Alsatian of about 3 years of age. Both dogs were sexually active and are utilized for breeding purposes. Samples were collected from the TVT growth on both the female and male genitalia. The samples were subjected to cytology and confirmatory diagnosis was made on the gross appearance of cauliformlike le

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Aung, Ei Thuzar, Umme Rubab, Mark Randon, Catherine Gilkes, Christina Daousi, and Sravan Thondam. "PMON120 Clinical Course Of Untreated Giant Invasive Macroprolactinomas- A Case Series." Journal of the Endocrine Society 6, Supplement_1 (2022): A535. http://dx.doi.org/10.1210/jendso/bvac150.1113.

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Abstract Introduction Giant invasive prolactinomas are rare pituitary tumours and have a male preponderance of 9: 1. In majority of cases, dopamine agonists (DA) are the treatment of choice in lowering prolactin and tumour shrinkage. Surgery may be opted in those with acute compressive symptoms or visual loss. Prolactinomas are known to invade the sellar floor, sphenoid sinus and clivus. Spontaneous CSF leak is rare in untreated patients with invasive prolactinomas compared to those on DA who respond with rapid tumour shrinkage that causes unplugging of the conduits resulting in CSF rhinorrhoe

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Ebrahimi-Nik, Hakimeh, Arvin Iracheta-Vellve, Kira E. Olander, et al. "Abstract A41: Small molecule inhibition of PTPN2/1 inflames the tumour microenvironment and unleashes potent CD8+ T cell immunity." Cancer Immunology Research 10, no. 12_Supplement (2022): A41. http://dx.doi.org/10.1158/2326-6074.tumimm22-a41.

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Abstract Immune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatase PTPN2 is a central regulator of inflammation, and genetic deletion of PTPN2 on either tumour cells or host immune cells promotes anti-tumour immunity. However, inhibitors of PTPN2 with suitable pharmacokinetic properties for oral administration have not been described. Here, we present the characterization of ABBV-CLS-484 (A484), a potent active site inhib

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Wang, Xiaojuan, Xing Sun, Hua He, et al. "A two-component active targeting theranostic agent based on graphene quantum dots." Journal of Materials Chemistry B 3, no. 17 (2015): 3583–90. http://dx.doi.org/10.1039/c5tb00211g.

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Kaufmann, J., G. Pronk, K. Giese, and A. Klippel. "Identification of novel effectors of invasive cell growth downstream of phosphoinositide 3-kinase." Biochemical Society Transactions 32, no. 2 (2004): 355–59. http://dx.doi.org/10.1042/bst0320355.

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Conventional approaches to identifying cancer targets are complicated by the chromosomal instability of tumour cells, and typically result in a large number of differentially expressed candidate genes with uncertain disease relevance. Here we present a novel approach which aims to elucidate the molecular changes that are induced after loss of tumour suppressor function. Using gene silencing tools, we mimic the loss of tumour suppressor function to identify key regulators of tumour initiation and progression. Loss of function of the tumour suppressor PTEN (phosphatase and tensin homologue delet

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Pang, Lisa Y., Emma A. Hurst, and David J. Argyle. "Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy." Stem Cells International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/2048731.

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Cyclooxygenase-2 (COX-2) is an inducible form of the enzyme that catalyses the synthesis of prostanoids, including prostaglandin E2 (PGE2), a major mediator of inflammation and angiogenesis. COX-2 is overexpressed in cancer cells and is associated with progressive tumour growth, as well as resistance of cancer cells to conventional chemotherapy and radiotherapy. These therapies are often delivered in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during treatment intervals, leading to repopulatio

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Reubi, J. C. "Central nervous system-mediated growth inhibition of a rat prostate carcinoma by an opioid." Journal of Endocrinology 107, no. 2 (1985): 247–50. http://dx.doi.org/10.1677/joe.0.1070247.

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ABSTRACT Long-term treatment for more than 3 months with a central nervous system (CNS)-active drug, the opioid agonist bremazocine, at a dose of 1 mg/kg per day elicited an 80% inhibition of the volume of the subcutaneously transplanted rat prostate adenocarcinoma Dunning R3327H. Whereas, under this therapy, prostate tumour and prostatic weights were decreased, testes and pituitary weights remained normal. Bremazocine inhibited not only the growth of freshly transplanted tumours but also that of well-grown Dunning prostate carcinomas since, after 41 days of treatment, such tumours showed a vo

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Marra, Giancarlo, Marco Oderda, Marco Allasia, Stefania Munegato, Steven Joniau, and Paolo Gontero. "A Review on the Management of Small Renal Masses: Active Surveillance Versus Surgery." Anti-Cancer Agents in Medicinal Chemistry 18, no. 7 (2018): 940–50. http://dx.doi.org/10.2174/1871520617666171113123443.

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Despite the rise of small renal tumour (SRMs) diagnosis and related surgeries, death rate of kidney cancer is increasing, suggesting a non-optimal management of SRMs. Active Surveillance (AS) for kidney cancer was introduced to deal with this paradox. However, incertitude remains on whether and when AS can replace surgery in selected patients. We performed a literature search, reviewed and discussed the evidence in favour of AS or surgery for SRMs. Histopathology and natural history of SRMs, including the percentage of benign tumours amongst SRMs, tumour growth rate, life expectancy of SRMs pa

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GARCKE, HARALD, and KEI FONG LAM. "Well-posedness of a Cahn–Hilliard system modelling tumour growth with chemotaxis and active transport." European Journal of Applied Mathematics 28, no. 2 (2016): 284–316. http://dx.doi.org/10.1017/s0956792516000292.

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We consider a diffuse interface model for tumour growth consisting of a Cahn–Hilliard equation with source terms coupled to a reaction–diffusion equation. The coupled system of partial differential equations models a tumour growing in the presence of a nutrient species and surrounded by healthy tissue. The model also takes into account transport mechanisms such as chemotaxis and active transport. We establish well-posedness results for the tumour model and a variant with a quasi-static nutrient. It will turn out that the presence of the source terms in the Cahn–Hilliard equation leads to new d

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Därr, Roland, Jonas Kater, Peggy Sekula, et al. "Clinical decision making in small non-functioning VHL-related incidentalomas." Endocrine Connections 9, no. 8 (2020): 834–44. http://dx.doi.org/10.1530/ec-20-0208.

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The optimal treatment strategy for patients with small non-functioning VHL-related incidentalomas is unclear. We searched the Freiburg VHL registry for patients with radiologic evidence of pheochromocytoma/paraganglioma (PHEO/PGL). In total, 176 patients with single, multiple, and recurrent tumours were identified (1.84 tumours/patient, range 1–8). Mean age at diagnosis was 32 ± 16 years. Seventy-four percent of tumours were localised to the adrenals. Mean tumour diameter was 2.42 ± 2.27 cm, 46% were <1.5 cm. 24% of tumours were biochemically inactive. Inactive tumours were significantly sm

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Ripamonti, M., G. Pezzoni, E. Pesenti, et al. "In vivo anti-tumour activity of FCE 23762, a methoxymorpholinyl derivative of doxorubicin active on doxorubicin-resistant tumour cells." British Journal of Cancer 65, no. 5 (1992): 703–7. http://dx.doi.org/10.1038/bjc.1992.148.

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Nagaraju, Santhosh, Ion Boiangiu, Ian Brown, Hussien El-Maghraby, and U. Pohl. "Intracranial myxoid mesenchymal tumour with EWSR1-ATF1 fusion mimicking high grade glioma." Neuro-Oncology 23, Supplement_4 (2021): iv23—iv24. http://dx.doi.org/10.1093/neuonc/noab195.059.

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Abstract Aims Molecular profiling is increasingly used in the diagnosis of CNS and non-CNS neoplasms. More than a quarter of all soft tissue tumours are characterized by specific recurrent chromosomal translocations which can be used as molecular signatures. With increasing frequency, EWSR1 rearrangements are found on both mesenchymal tumours and primary glial/neuronal tumours. Here we present a case of intracranial myxoid mesenchymal tumour (IMMT), a rare tumour which is becoming more recognised in recent years, affecting mainly children and young adults, and rarely older adults. It can be fo

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Shiono, Junko, Hitoshi Horigome, Seiyo Yasui, et al. "Electrocardiographic changes in patients with cardiac rhabdomyomas associated with tuberous sclerosis." Cardiology in the Young 13, no. 3 (2003): 258–63. http://dx.doi.org/10.1017/s1047951103000507.

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Background:Cardiac rhabdomyomas associated with tuberous sclerosis induce various abnormalities in the electrocardiogram. Electrocardiographic evidence of ventricular hypertrophy may appear if the tumour is electrically active. To our knowledge, electrocardiographic evidence of ventricular hypertrophy has been reported only in association with congestive heart failure. Follow-up studies of changes in electrocardiographic findings are also lacking.Methods:We studied 21 consecutive patients with cardiac rhabdomyoma associated with tuberous sclerosis, 10 males and 11 females, aged from the date o

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Kutlvasr, K., K. Bukovjan, and R. Kodet. "Bilateral low grade serous adenocarcinoma of the ovaries in a badger (Meles meles L.) and its association with a borderline serous ovarian tumour: a case report." Veterinární Medicína 59, No. 1 (2014): 44–50. http://dx.doi.org/10.17221/7245-vetmed.

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Here, we describe a case of a wild female badger (a sow) with disseminated serous adenocarcinoma of the ovary which corresponds to a group of low grade serous carcinomas of the ovary in humans. Beside grossly apparent dissemination of the disease we observed a scale of histological features classifiable as a precursor lesion &ndash; borderline serous tumour of the ovary with implant metastases at the peritoneum, and features of the borderline tumour transformation in the carcinoma. The latter features included invasion of some of the metastatic peritoneal implants into the adipose tissue o

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NATHER, A., and I. H. SUTHERLAND. "Malignant Transformation of a Benign Cutaneous Mixed Tumour." Journal of Hand Surgery 11, no. 1 (1986): 139–43. http://dx.doi.org/10.1016/0266-7681_86_90039-2.

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Whilst benign cutaneous mixed tumour is common, malignant cutaneous mixed tumour is rare. There are only eleven accepted cases of the malignant counterpart in the literature. In none was there residual benign tumour tissue present to suggest that they arose from malignant transformation of the benign tumour. We report a very rare case of a malignant transformation of a benign cutaneous mixed tumour in an eighty-four year old female. Other unusual features in this case included considerable involvement of bone in the primary lesion and the histological picture of extreme pleomorphism and active

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