Dissertations / Theses on the topic 'Tumors Measurement'
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Verleyen, Wim. "Machine learning for systems pathology." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4512.
Full textKavanagh, Mary-Claire Anne. "Measurement of oxygen levels in murine tumours." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0009/NQ41447.pdf.
Full textCollingridge, David Roy. "Measurement and manipulation of tumour oxygen tension." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299928.
Full textCalhoun, Mark A. II. "Measurement and Variation of the Mechanical Environment in Glioblastoma." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506.
Full textLawton, Patricia Ann. "The measurement of intrinsic cellular radiosensitivity in human tumours and normal tissues." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283750.
Full textWarmuth, Carsten. "Nichtinvasive Magnetresonanz-Perfusionsmessung des Gehirns mittelsMagnetischer Blutbolusmarkierung(Spin-Labeling)." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/15025.
Full textArterial spin labeling methods allow to determine quantitative tissue blood flow values noninvasively. Arterial blood is labelled by an inversion pulse and the distribution of this intrinsic tracer is measured using magnetic resonance imaging. Experiments using an extra corporal in-vitro porcine kidney in a MR compatible set-up were carried out to determine the accuracy of blood flow values calculated from arterial spin labeling measurements. In a study of 36 brain tumor patients, spin labeling was compared to non-quantitative contrast-enhanced dynamic susceptibility-weighted perfusion imaging. Relative blood flow values determined with both methods were in good agreement, the linear regression coefficient in the tumor region was R=0.83. Due to the variable individual perfusion state, quantitative blood flow values determined using spin labeling play a minor role in the assessment of tumor grade. Application of spin labeling to angiography of major arteries was investigated. Dynamic spin labeling angiography (DSLA) sequences were implemented and tested on a clinical scanner. This technique allows time-resolved depiction of blood flow in large vessels with very high temporal resolution. As opposed to digital subtraction angiography, the method allows arbitrary projection directions. In a study, 18 patients with one-sided carotid stenoses were examined. In these patients the time differences of blood bolus arrival at both hemispheres were determined. Time differences measured in the carotid siphon show a significant correlation with the degree of stenosis. However, a clear increase is not seen until 80% narrowing of a carotid. Possibilities and limitations of the DSLA method are discussed in comparison to established techniques.
McHugh, Damien Joseph. "The effect of tumour microstructure on diffusion-weighted MRI measurements." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-effect-of-tumour-microstructure-on-diffusionweighted-mri-measurements(9821717e-df69-4dd0-baf7-51cf27a18aa2).html.
Full textGhara'ati, H. "The use of tomography images in the XRF measurement of platinum in tumours following chemotherapy." Thesis, Swansea University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637048.
Full textRichter, Johan. "Fluorescence Guided Resection of Brain Tumors : Evaluation of a Hand-held Spectroscopic Probe." Doctoral thesis, Linköpings universitet, Institutionen för medicinsk teknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139793.
Full textMaligna hjärntumörer växer infiltrerande i hjärnan och kan därförinte helt avlägsnas genom kirurgiska operationer. För en optimerad behandling har det emellertid visat sig vara av värde att avlägsna såmycket som möjligt av tumörvävnaden. Identifiering av tumören i gränszonen är mycket svårt, men avgörande. Studier har visat att visualisering av den specifika laddningen av 5-aminolevulinsyra (5-ALA) i tumören kan bidra till att maximera resektionen. Institutionen för Medicinsk Teknik (IMT) på Linköpings universitet,har utvecklat en liten handhållen optisk prob (HHP) för att identifiera tumörvävnad med hög känslighet med hjälp avfluorescens-spektroskopi. Den tekniska konstruktionen och de optiska egenskaperna hos proben utvecklades stegvis genom testning i flera neurokirurgiska operationer för resektion av maligna gliom. Utrustningen uppfyllde alla krav när det gällde steril hantering i operationssalen och kunde användas utan störningar av något slag med annan operationsutrustning. Integreringen i ett navigerings-system och användningen i kombination med ett kirurgiskt mikroskop för fluorescens-styrd kirurgi var oproblematiska. Mätningar under 27 operationer vid resektion av maligna gliom jämfördes med resultat från biopsier från samma tumörtagningsställen. Utrustningen testades såväl som en fristående enhet (n = 180) och som integrerad i ett navigationssystem eller i kombination med mikroskopet (n =190). En särskild kvot beräknad ur mätningarna möjliggjorde objektiva och jämförbara värden för olika vävnader, i överensstämmelse med resultaten från de vävnadspatologiska undersökningarna och i överensstämmelse med navigationssystemet såväl som med det kirurgiska mikroskopet. Tumörernas gränszon undersöktes och tumörfluorescens kunde identifieras bortom fluorescensen som mikroskopet visade. En högre känslighet hos HHP bekräftades; specificiteten var lägre. Den kombinerade användningen av HHP med ett navigationssystem och med ett kirurgiskt mikroskop visade sig vara fördelaktig.
Leach, Eric. "KNOWLEDGE BASED MEASUREMENT OF ENHANCING BRAIN TISSUE IN ANISOTROPIC MR IMAGERY." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3341.
Full textM.S.E.E.
School of Electrical Engineering and Computer Science
Engineering and Computer Science
Electrical Engineering MSEE
Carter, Paul Gareth. "The measurement of urinary #beta# core in women with lower genital tract cancer and its prognostic significance." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298463.
Full textJayasundar, Rama. "Magnetic resonance studies in oncology : measurement of the effects of hyperthermia on tumour pH." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335171.
Full textHenderson, Elizabeth. "Measurement of blood flow, blood volume and capillary permeability in breast tumours using contrast-enhanced magnetic resonance imaging." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/NQ58134.pdf.
Full textHeikkonen, Jorma. "Partition coefficients and tumour blood flow measurements using radioactive 41Ar, 85mKr and 133Xe." Helsinki : Soc. Scient. Fennica, 1988. http://catalog.hathitrust.org/api/volumes/oclc/64258891.html.
Full textDong, Lixin. "DIFFUSE OPTICAL MEASUREMENTS OF HEAD AND NECK TUMOR HEMODYNAMICS FOR EARLY PREDICTION OF CHEMO-RADIATION THERAPY OUTCOMES." UKnowledge, 2015. http://uknowledge.uky.edu/cbme_etds/35.
Full textDe, Jaeger Katrien. "Relationship between polarographic oxygen measurements, metastatic ability and EF5 binding in murine tumour models." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ46062.pdf.
Full textBennett, C. A. "The optimisation of an X-Ray fluorescence system for the in vivo measurement of platinum in head and neck tumours." Thesis, Swansea University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636079.
Full textToma-Dasu, Iuliana. "Theoretical modelling of tumour oxygenation and influences on treatment outcome." Doctoral thesis, Umeå University, Radiation Sciences, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-262.
Full textOne of the main problems in curing cancer resides in the different microenvironment existing in tumours compared to the normal tissues. The mechanisms of failure are different for radiotherapy and chemotherapy, but they all relate to the poor blood supply known to exist in tumours. It is therefore very important to know the tumour microenvironmental conditions in order to devise techniques that will overcome the problems and will therefore improve the result of the treatment.
The aims of the thesis were the modelling of tumour oxygenation and the simulation of polarographic oxygen measurements in order to assess and possibly to improve the accuracy of the electrode in measuring tumour oxygenation. It also aimed to evaluate the implications of tumour microenvironment for the radiotherapy outcome.
The project used theoretical modelling as the main tool. The processes of oxygen diffusion and consumption were described mathematically for different conditions, the result being very accurate distributions of oxygen in tissues. A first simple model of tissue oxygenation was based on the oxygen diffusion around a single blood vessel. A more complex model built from the basic physical processes and measurable parameters allowed the simulation of realistical tissues with heterogeneous vasculature. This model also allowed the modelling of the two types of hypoxia known to appear in tumours and their influence on the tumour microenvironment. The computer simulation of tissues was also used for assessing the accuracy of the polarographic technique for measuring tumour oxygenation.
The results of this study have shown that it is possible to model theoretically the tissue oxygenation starting from the basic physical processes. The particular application of our theoretical simulation to the polarographic oxygen electrode has shown that this experimental method does not give the oxygen values in individual cells. Because the electrode measures the average oxygenation in a relatively large tissue volume, the resulting oxygen distributions are different from the real ones and the extreme high and low values are not detected. It has further been found that the polarographic electrode cannot make distinction between various types of hypoxia existing in tumours, the geometrical distribution of the hypoxic cells influencing mostly the accuracy of the measurement.
It was also shown that because of the averaging implied by the measurement process, electrode results should not be used directly to predict the response to radiation. Thus, the differences between the predictions in clinical tumour control obtained from the real or the measured oxygenations are of the order of tens of percents in absolute value. A method to improve the accuracy of the electrode, i.e. to improve the correlation between the results of the measurements and the actual tissue oxygenation, was proposed.
In conclusion, theoretical modelling has been shown to be a very powerful tool for predicting the outcome of radiotherapy and it has the advantage of describing the tumour oxygenation in the least invasive manner. Furthermore it allows the investigation of the invasiveness and the accuracy of various experimental methods.
Lowndes, Shannely. "Blood interference in fluorescence spectrum : Experiment, analysis and comparison with intraoperativemeasurements on brain tumor." Thesis, Linköpings universitet, Biomedicinsk instrumentteknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60676.
Full textSellner, Stefan [Verfasser], and Joachim [Akademischer Betreuer] Ullrich. "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue. / Stefan Sellner ; Betreuer: Joachim Ullrich." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177810581/34.
Full textIslam, Naimul. "The potential for using combined electrical impedance and ultrasound measurements for the non-invasive determination of temperature in deep body tumours during mild hyperthermia." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/56721/.
Full textSetoyama, Takeshi. "Development of novel bioassay for the measurement of bioactive insulin-like growth factors in blood samples and treatment strategy targeting the bioactive insulin-like growth factors for non-islet cell tumor hypoglycemia." Kyoto University, 2016. http://hdl.handle.net/2433/204576.
Full textLignon, Dominique. "Élaboration d'un dispositif adapte a la photochimiothérapie des tumeurs de vessie : électronique, capteurs, traitement du signal et contrôle de la dosimétrie laser." Vandoeuvre-les-Nancy, INPL, 1993. http://www.theses.fr/1993INPL053N.
Full textShih, Yih-Lih, and 施易利. "NIR Electro-optical Measurement and Analysis for the Heterogeneous Intralipid Phantoms Imitating Breast Tumors." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/08906851644095925933.
Full text國立中央大學
機械工程研究所
94
Near infrared (NIR) diffuse optical tomography (DOT) is a new medical imaging modality, the advantages are safe (longer wavelength) and non-radioactive, in spite of its low spatial resolution at the current phase. Due to the diagnostic potential of NIR,the abnormality of tissues in NIR light is to allow earlier detection rather than most other imaging modalities. This thesis describes the NIR Electro-optical measurement for Intralipid phantoms using our own developed NIR DOT scanning instrument with highly spatially angular resolution, in order to investigate the influence of different factors such as the off-boundary, the volume density (v.d.) of inclusion, and the size ratio. The influence of each condition also can reveal the real condition of biomedical tissue, and this information can offer the doctor for diagnosis. This thesis discusses Intralipid phantoms which are the homogeneous background with one inclusion or two inclusions. For the homogeneous background with one inclusion and the source position at s0 , the contrast is large, the resolution of inclusion position is good but the resolution of inclusion size is bad. The off-boundary is small, the resolution of contrast and inclusion size are both good. The inclusion size is large, the resolution of contrast is good but the resolution of off-boundary is bad. For the homogeneous background with two inclusions and the source position at s0 , the contrast (I0) is large; the resolution of inclusion position is good. The off-boundary (I0) is small confined to the non-directly detected inclusion (I4) with small v.d.; the resolution of contrast is good. The common conclusion for the homogeneous background with one inclusion and two inclusions can be obtained. Those phenomena are similar in some condition, especially for source position at s0 and Sπ. This thesis also simulates a power curve by using an exponential form. The light trajectory of model in this thesis was set as straight line, unlike the real trajectory. The outcome does not seem well. From this thesis, it can give a general concept about the influence of different factors. Furthermore, the original experimental data can be used as the input and the calibration of image reconstruction.
Lin, Chih-Huang, and 林志泓. "3D Measurements of Ultrasonic Image of Ovarian tumor." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/90235804066474455228.
Full text義守大學
電子工程學系
87
3D Measurements of Ultrasonic Image of Ovarian tumor Chih-Huang Lin* Ching-Fen Jiang** Dept. of Electronic Engineering ,I-Shou University Kaohsiung, Taiwan, ROC Abstract Ovarian cancer is one of the most mortal female cancers in the civilized countries. Ultrasonic technique is a popular detection facility. In the way to judge the ovarian tumor malignancy on the Ultrasonic image, doctor usually look for the surface of the ovarian tumor. If the surface of the ovarian tumor is irregularity, there will be a prevalence with which the tumor is ovarian cancer. However, it is not easy to quantify the irregularity of the ovarian tumor in the 2D ultrasonic image. Therefore a quantitative analysis of the complexity of 3D surface of ovarian tumor can assist doctors to improve the correctness of the diagnosis. In this study, We firstly developed a new method to detect the 3D contour of the ovarian tumor. Our new method was based on the classified image of ovarian. Previous works of the classified image of ovarian tumor have provided us an well-contrast image for edge detection. After edge detection of ovarian tumor, we make used of the Fractal model to analysis the complexity of the 3D surface of ovarian tumor. Fractal dimension is not a integer dimension. In addition, the more complicated the object is, the higher the fractal dimension of the object have. According to the property of fractal dimension, the irregular degree of ovarian tumor was successfully determined. Key word :3D ultrasonic image, ovarian tumor, Fractal geometry, Fractal dimension *The author **The advisor
Huang, Shu-wei, and 黃書偉. "Measurement Tumor Vessels of the Nude Mice Using Photoacoustic Tomography Imaging." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/23584555601266489890.
Full text國立陽明大學
醫學工程研究所
94
Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast than conventional ultrasound imaging due to the high contrast absorption of blood vessels to green and near infrared (NIR) light. Hemoglobin is the most significant optical absorber in human blood; it offers strong optical contrast at 532nm optical wavelengths and makes the photoacoustic technique particularly well suited for imaging blood vessels. The photoacoustic system includes a Nd:YAG laser, operating at 532 nm wavelength, a 2.25MHz and 20MHz ultrasonic transducer, an X-Y axes piezo ceramic stage, and a computer user interface. Utilizing synthetic aperture technique improved the time delay of photoacoustic image, obtained better image resolution and signal-to-noise ratio (SNR), the SNR was improved about 3dB. We measured the photoacoustic imaging resolution about 0.7mm using 20MHz ultrasonic transducer. This study can divide plane scanning and depth scanning. In plane scanning, we scanned hair and 10 days chicken embryo, can differentiable vessels distribution. In depth scanning, we measured blood vessels form human cutaneous veins and 3-21 days tumors of the nude mice in-vivo. A series of 2D photoacoustic imaging of the blood vessels of the human forearm can differentiable vessels distribution at different place. In tumors of the nude mice, using photoacoustic imaging compared with ultrasound imaging, we observe that the photoacoutic signals change with the growth of the tumor, blood concentration change inside the tumor and growth in depth of the neovascularized region. In clinical, we expect photoacoustic technique detected neovascularized in tumor noninvaded.
Wu, Meng-Shu, and 吳孟書. "Collection and Impedance Measurement of Circulating Tumor Cells from the Whole Blood Samples." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/22859777715022347744.
Full text國立中正大學
機械工程學系暨研究所
103
The detection of rate cells, such as circulating tumor cells (CTCs), circulating fetal cells, is important for medical diagnostics and characterization. In order to detect tumor cells precisely, the red blood cells and white blood cells buffer lysis were added to the whole blood sample before measuring. The RBCs (Red blood cells) and WBCs (white blood cells) were lysed and the experimental result was found that the survival rate of HeLa was about 80 %. However, the survival rate of RBCs was around only 10 %. The main purpose of this study is to trap cancerous cells (HeLa) in the proposed microchip, then measure the impedance of HeLa cells using lock-in amplifier after lysing blood cells. Circular microelectrodes were fabricated by the standard photolithography technique to trap the positive dielectrophoretic cells by applying a AC voltage of 5 to 10 Vpp with a frequency of 1 MHz. After cells were captured, a measuring AC of 1 Vpp with 4 kHz was applied. Meanwhile, the flow rate of 1 μL/min was also applied to reduce the loss rate of captured cells to approximately 5 – 8 %.This microfluidic device is easy to operate and integrate into further biomedical applications and technology. The detection of cancerous cells in the microchip proposed herein is sensitive and the interference of blood cells could be avoided.
Al-Hallaq, Hania A. "Measurement of changes in tumor oxygenation by high spectral and spatial resolution MRI /." 2000. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9977996.
Full textFichtner, Nicole Damara. "MR Diffusion Measurements of Apoptotic Changes in Tumour Cells." Thesis, 2013. http://hdl.handle.net/1807/35606.
Full textCheng, Chieh-Fang, and 鄭傑方. "Design of Tracking System with Respiratory Flow Measurement in High Intensity Focused Ultrasound Liver Tumor Treatment." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/19575422820089353008.
Full text國立臺灣大學
電機工程學研究所
96
In the research of treating tumors, High Intensity Focused Ultrasound (HIFU) is one of the popular treatment methods in the recent years. The treatment in the moving tumor is always a serious problem. A number of methods can solve this in the radiotherapy. Comparing Real-Time Radiotherapy Tracking System (RTRT), there is not a nicer HIFU tracking treatment system so NTU MRI Guided HIFU Tracking System was developed before. A Magnetic Resonance Imaging (MRI) system guides HIFU in this system. In order to solve the delay time produced in the liver position determination system, the neural network is a predictor. The predicted position is used to control the position of the ultrasound transducer. Some tracking errors always exist in NTU MRI Guided HIFU Tracking System and therefore the performance is not good enough. It is the reason to improve HIFU tracking system. In order to get a better performance, a respiration signal measurement system replaced MRI system and a mapping system replaced the liver position determination system. The mapping system is used to transform the respiration signal into the liver position. The system is called NTU Respiration Signal Based HIFU Tracking System. A higher sampling rate of getting liver positions is in this system. The tracking error of this system is lower than the tracking error of NTU MRI Guided HIFU Tracking System. The performance of NTU Respiration Signal Based HIFU Tracking System is also better. Some comparisons verify the new design can bring the improvement in the performance of tracking.
Cheng, Chieh-Fang. "Design of Tracking System with Respiratory Flow Measurement in High Intensity Focused Ultrasound Liver Tumor Treatment." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2907200811524500.
Full textMarkus, Rohrschneider, Gerik Scheuermann, Stefan Höhme, and Dirk Drasdo. "Shape Characterization of Extracted and Simulated Tumor Samples using Topological and Geometric Measures." 2007. https://ul.qucosa.de/id/qucosa%3A31954.
Full textvon, Neubeck Cläre. "Radiobiological experiments for carbon ion prostate cancer therapy: Interplay of normal and tumor cells in co-culture and measurement of the oxygen enhancement ratio." Phd thesis, 2009. https://tuprints.ulb.tu-darmstadt.de/1973/1/Cl%C3%A4re_PhD.pdf.
Full textSureshkumar, Ahthavan R. "Investigation into the Origin and Nature of Variability in Quantitative Measurements of Tumour Blood Flow with Contrast-enhanced Ultrasound." Thesis, 2012. http://hdl.handle.net/1807/33547.
Full textHochhauser, Daniel, Timothy Meyer, Victoria J. Spanswick, Jenny Wu, Peter H. Clingen, Paul M. Loadman, Margaret Cobb, et al. "Phase 1 Study Of A Sequence Selective Minor Groove DNA Binding Agent (SJG-136) with Pharmacokinetic and Pharmacodynamic Measurements in Patients with Advanced Solid Tumours." 2009. http://hdl.handle.net/10454/4564.
Full textPratt, Michelle Sherman. "Comparison of linear, bi-dimensional, and volumetric measurements in evaluating tumor response of hepatocellular carcinoma lesions in the arterial and portal venous phases on MRI." Thesis, 2015. https://hdl.handle.net/2144/15617.
Full textNeubeck, Cläre von [Verfasser]. "Radiobiological experiments for carbon ion prostate cancer therapy : interplay of normal and tumor cells in co-culture and measurement of the oxygen enhancement ratio / von Cläre von Neubeck." 2009. http://d-nb.info/999116827/34.
Full textMangelsdorf, Johanna. "Vergleich unidimensionaler, bidimensionaler und volumetrischer Messverfahren unter Anwendung eines 64-Zeilen-Mehrschicht-CTs am Beispiel von Bronchialkarzinomen und pulmonalen Metastasen." Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-AF5E-E.
Full textHäring, Steffi. "Die organ- und visuserhaltende Brachytherapie kindlicher intraorbitaler Tumoren ein Vergleich der Dosierung mit den Richtlinien des Reports 58 der International Commission on Radiation Units and Measurements /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014188954&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textBlair, Alexandra. "Addressing gaps in colorectal cancer screening in Canada : multilevel determinants of screening, pathways to screening inequalities, and program evaluation." Thèse, 2018. http://hdl.handle.net/1866/22576.
Full text