Relevant bibliographies by topics / Tumors in children

Academic literature on the topic 'Tumors in children'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 July 2024

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Journal articles on the topic "Tumors in children"

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Mathew, George, and Shwetha Jose. "PRIMARY TUMORS AND TUMOR-LIKE LESIONS OF BONE IN CHILDREN." International Journal of Integrative Medical Sciences 4, no. 6 (November 3, 2017): 507–11. http://dx.doi.org/10.16965/ijims.2017.112.

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Joaquim, Andrei Fernandes, Enrico Ghizoni, Marcelo Gomes Cordeiro Valadares, Simone Appenzeller, Simone dos Santos Aguiar, and Helder Tedeschi. "Spinal tumors in children." Revista da Associação Médica Brasileira 63, no. 5 (May 2017): 459–65. http://dx.doi.org/10.1590/1806-9282.63.05.459.

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Summary Introduction: Spinal tumors are rare in the pediatric population, presenting many specific peculiarities when compared to adults. We have performed a broad narrative review to describe the most common spinal tumors in children, discussing their main characteristics and management options. Method: The authors have performed an extensive review of the peer-reviewed literature addressing the aforementioned objectives. Results: Multimodality radiological studies (plain films, 3D computed tomography scan and magnetic resonance imaging) are necessary for proper evaluation and differential diagnosis of spinal tumors in children. In selected cases nuclear medicine imaging is used to improve the chances of a more accurate diagnosis. As a general rule, a fine needle biopsy is recommended after radiological evaluation to confirm the tumor's histology. Primary bone tumors can be divided into benign bone tumors, mostly represented by vertebral hemangiomas, osteoid osteomas, osteoblastomas, aneurismal bone cysts, and eosinophilic granulomas, and malign or aggressive tumors, such as Ewing's or osteogenic sarcomas. Secondary bone tumors (spinal metastases) comprise different tumor histologies, and treatment is mainly based on tumor's radiosensitivity. The characteristics and treatment options of the main spinal tumors are discussed in details. Conclusion: Spinal tumors in children are rare lesions that demand a thorough understanding of their main characteristics for their proper management. Understanding the nuances of spinal tumors in children is of paramount importance for improving outcomes and chances of cure.
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Akyol, Şefika. "Kidney Tumors in Children." Journal of Pediatric Academy 4, no. 2 (June 22, 2023): 44–49. http://dx.doi.org/10.4274/jpea.2023.237.

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Wilms tumor (WT) is an embryonal tumor of the kidneys. It is associated with many oncogenic genetic aberrations and congenital anomalies. Owing to worldwide clinical research and optimized patient care, curative therapy can be obtained in 90% of diagnosed children with WT. The decision of treatment mainly depends on stage, age, histological type, and genetic markers. Except for WT; congenital mesoblastic nephroma, clear cell sarcoma, malignant rhabdoid tumor, and renal cell carcinoma constitute 5% of kidney tumors. Herein, WT and other tumors of the kidney will be emphasized.
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Llempén, Mercedes, Gema Ramírez, Rosa Cabello, and Catalina Márquez. "Adrenocortical tumors in children." Revista Médica de Trujillo 14, no. 3 (August 19, 2019): 152–59. http://dx.doi.org/10.17268/rmt.2019.v14i03.08.

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Edwards, Michael S. B., Roger J. Hudgins, Charles B. Wilson, Victor A. Levin, and William M. Wara. "Pineal region tumors in children." Journal of Neurosurgery 68, no. 5 (May 1988): 689–97. http://dx.doi.org/10.3171/jns.1988.68.5.0689.

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✓ The authors believe that the preferred treatment for pineal region tumors in children requires definitive surgery with a histological diagnosis and that a conservative approach consisting of shunting and radiation therapy no longer seems to be appropriate. The results are reported of a retrospective review of the presentation, treatment, and outcome of 36 children under the age of 18 years treated between 1974 and 1986. Eleven children had germinomas (two-cell type), seven had astrocytomas, and the remaining 18 had 15 histologically different tumor types. Surgery was performed on 30 patients; there were no deaths, but a 10% rate of persistent morbidity was found. The median follow-up period was 4 years. Nine (82%) of 11 patients with germinomas are alive without evidence of recurrence; one child died from recurrent tumor in the pineal region and another is presently being treated for recurrent tumor of the spinal cord. Six (86%) of the seven patients with astrocytoma are well after biopsy and radiation therapy. Of the remaining 18 children, five (28%) died from tumor progression. The cerebrospinal fluid (CSF) tumor markers α-fetoprotein and β-human chorionic gonadotropin were helpful in determining the presence of malignant germ-cell tumors, particularly those with a poor prognosis. Magnetic resonance imaging was useful for diagnosis and for planning the operative approach. Magnetic resonance images showed the presence of pineal region tumors in four children with hydrocephalus who had no evidence of tumor on computerized tomography scans. Because the great variety of tumor types found in the pineal region must be treated in different ways and because improved microsurgical and stereotaxic surgical techniques have made mortality and morbidity rates acceptably low, a biopsy diagnosis should be obtained in all patients. Preoperative assessment of CSF tumor markers and cytology is useful for the identification of patients who have a poor prognosis.
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Ostwal, Piyush, and Shanbhag Nandan. "SEIZURES IN CHILDREN WITH LOW GRADE GLIOMA." MNJ (Malang Neurology Journal) 7, no. 1 (January 1, 2021): 60–65. http://dx.doi.org/10.21776/ub.mnj.2021.007.01.12.

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Seizures are a common presentation of pediatric brain tumors. The incidence of pediatric brain tumor (Age 0-19 years) ranges from 1.12–5.26 cases per 100,000 persons. Low grade gliomas are an important subgroup of pediatric brain tumors causing epilepsy. Low-grade gliomas are largely slow-growing tumors and the manifestations are dependent on age, location, tumor type, size of tumor and rate of tumor growth. Seizures have been reported in up to 38 % of children with supratentorial tumors. The tumors are identified when work up of patients for epilepsy includes electrophysiological and imaging studies. The primary treatment modality remains surgical excision. Antiepileptic medications are used for control of seizures. Subsequent histopathological diagnosis is important for prognostication. The tumors commonly associated with long-term epilepsy in various studies were ganglioglioma, dysembryoplastic neuroepithelial tumor, pilocytic astrocytoma and pilocytic xanthoastrocytoma. The outcome of surgery with regards to seizure control is generally good. Though concomitantly antiepileptic medications will be needed for most of them. An attempt is made in this review to summarize the epidemiology, clinical features, pathology and treatment aspects of pediatric low grade gliomas presenting with seizures.
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Alimoukhamedova, G. A., and Z. Yu Khalimova. "ANDROGEN-SECRETING ADRENAL TUMORS." International Journal of Medical Sciences And Clinical Research 02, no. 04 (April 1, 2022): 16–22. http://dx.doi.org/10.37547/ijmscr/volume02issue04-03.

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The objective of this research was to study clinical peculiarities of androgen-secreting tumors in adrenals dependent on age and gender. Among the patients with various neoplasms in adrenals (n=282), who received out-patient and in-patient treatment in the Republican Specialized Scientific Practical Medical Center of Endocrinology of the Uzbekistan Public Healthcare Ministry within the period from 2000 to 2018, androgen-secreting tumors were diagnosed in 9(3.2%) patients: 3(33.3%) men and 6(66.7%) women aged from 1.7 to 34 years old. As well as in the other groups with adrenal neoplasms, there was double prevailing of women. However, correlation of separate age subgroups was significantly different. In this group of patients specific weight of children increased (55.6%) compared to adults under 44 years old (44.4%). In spite of similar etiopathogenetic basis analysis of clinical manifestations of adrenal androgen-secreting tumors in children and adults revealed some differences. So, performed analysis confirms the presence of several symptoms in children, symptoms which are not observed in adults. On the other hand, somatic disorders in adults are more expressed than in children.
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Bartels, Loren J., and Michael Gurucharri. "Pediatric Glomus Tumors." Otolaryngology–Head and Neck Surgery 99, no. 4 (October 1988): 392–95. http://dx.doi.org/10.1177/019459988809900407.

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Glomus tumors of the middle ear are unusual in adults, but exeedingly rare in children. While a dull, red bulging tympanic membrane in the adult may suggest a glomus tumor, it generally signifies infection in the child. This report details our management of a 10-year-old girl afflicted with bilateral chronic middle ear cleft infection that obscured bilateral glomus tumors. Review of the current English language literature reveals seven additional case reports of otologic glomus tumors in children less than fourteen years of age. Two additional cases are presented that were given to the senior author by personal communication, producing a total of 10 cases for review. Glomus tumors in children may be hidden by otitis media and appear more likely to be endocrine active. Failure to cure the lesion is apparent in five of six case reports of children with glomus jugulare tumors; three of these children are reported to have expired. Complete surgical extirpation is advocated for childhood glomus tumors.
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Akhaladze, D. G., G. S. Rabaev, and N. S. Grachev. "Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in children." Pediatric Hematology/Oncology and Immunopathology 18, no. 4 (December 31, 2019): 118–26. http://dx.doi.org/10.24287/1726-1708-2019-18-4-118-126.

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Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is treatment of choice for determined group of adult patients. Cytoreduction and HIPEC is usually used in patients with ovarian, gastric and colorectal cancer, appednix cancer, peritoneal mesothelioma and in some tumors of another localization. The experience of cytoreductive surgery and HIPEC in childhood is limited due to the lower frequency of peritoneal carcinomatosis in pediatric population. However, about 30% of malignant tumors in children develop in peritoneal cavity and pelvis. High recurrence rate are typical for these tumors, particularly due to tumor rupture. Taking into consideration low frequency of epithelioid tumors in children HIPEC is used for patients with other tumor types such as desmoplastic small round cell tumor (DSRCT), germ cell tumors, rhabdomyosarcoma and others. The aim o this paper is the review of the literature and present experience analysis of cytoreductive surgery and HIPEC in children.
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McAbee, Joseph H., Joseph Modica, Clinton J. Thompson, Alberto Broniscer, Brent Orr, Asim F. Choudhri, Frederick A. Boop, and Paul Klimo. "Cervicomedullary tumors in children." Journal of Neurosurgery: Pediatrics 16, no. 4 (October 2015): 357–66. http://dx.doi.org/10.3171/2015.5.peds14638.

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OBJECT Cervicomedullary tumors (CMTs) represent a heterogeneous group of intrinsic neoplasms that are typically low grade and generally carry a good prognosis. This single-institution study was undertaken to document the outcomes and current treatment philosophy for these challenging neoplasms. METHODS The charts of all pediatric patients with CMTs who received treatment at St. Jude Children’s Research Hospital between January 1988 and May 2013 were retrospectively reviewed. Demographic, surgical, clinical, radiological, pathological, and survival data were collected. Treatment-free survival and overall survival were estimated, and predictors of recurrence were analyzed. RESULTS Thirty-one children (16 boys, 15 girls) with at least 12 months of follow-up data were identified. The median age at diagnosis was 6 years (range 7 months-17 years) and the median follow-up was 4.3 years. Low-grade tumors (Grade I or II) were present in 26 (84%) patients. Thirty patients underwent either a biopsy alone or resection, with the majority of patients undergoing biopsy only (n = 12, 39%) or subtotal resection (n = 14, 45%). Only 4 patients were treated solely with resection; 21 patients received radiotherapy alone or in combination with other treatments. Recurrent tumor developed in 14 children (45%) and 4 died as a result of their malignancy. A high-grade pathological type was the only independent variable that predicted recurrence. The 5- and 10-year treatment-free survival estimates are 64.7% and 45.3%, respectively. The 5- and 10-year overall survival estimate is 86.7%. CONCLUSIONS Children with CMTs typically have low-grade neoplasms and consequently long-term survival, but high risk of recurrence. Therapy should be directed at achieving local tumor control while preserving and even restoring neurological function.
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Dissertations / Theses on the topic "Tumors in children"

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Britt, Deanna C. "Thoughts, feelings, and actions : a restrospective study of the coping efforts of pediatric cancer patients in the context of the home, institution, and community /." This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-07282008-134837/.

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Cornman, Barbara Jane. "Impact of childhood cancer on the family /." Thesis, Connect to this title online; UW restricted, 1988. http://hdl.handle.net/1773/7827.

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Castro, Cynthia M. "Relationships between nonprocedural pain and psychological distress in children and adolescents with cancer /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9726021.

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McCormack, Sarah (Sarah Smith). "Memory Functions among Children Irradiated for Brain Tumor." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278041/.

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Children who have received radiation therapy for the treatment of brain tumors have been shown to experience neurocognitive deficits which appear to increase over time. The purpose of this study was to examine the memory functioning of 22 children irradiated for brain tumor and 22 healthy children of the same age who had not received irradiation. Subjects were administered a brief form of the WISC-III, to obtain an IQ, and the Wide Range Assessment of Memory and Learning (WRAML), to evaluate visual and verbal memory. Results indicated that, although there were no significant differences between the IQ scores of healthy children and children who had been irradiated, children who have received radiation therapy for brain tumor evidence memory deficits which effect visual and verbal memory abilities. Among the children who had been irradiated, as time since treatment increased, visual memory and overall memory functioning appeared to decline. Findings also suggested that children who received total tumor resection may evidence greater memory deficits than those who received only a partial resection. Visual memory was more closely related to IQ in the children irradiated for brain tumor than in the healthy children. The overall importance of research with this population lies in refining the understanding of memory deficits and strengths in order to formulate more effective remediation compensation, strategies.
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Niesen-Vertommen, Sherri. "The recovery patterns and effects of exercise rehabilitation on the physiological and psychological health of children who have survived treatment for a malignancy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0008/NQ34599.pdf.

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Britt, Deanna C. "Thoughts, feelings, and actions: a retrospective study of the coping efforts of pediatric cancer patients in the context of the home, institution, and community." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/38914.

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This study was a retrospective examination of the experiences of pediatric cancer patients and their families from a contextual perspective. The home, institution, and community contexts were investigated to reveal their influences on the coping efforts of the study participants. Ten families of children with cancer were interviewed, and data were analyzed qualitatively. Walker's (1985) family stress model and Lazarus' (1984) coping paradigm guided the study. The findings indicated that children were ambivalent in their attitudes toward the disease process. While they did not enjoy painful procedures, sickness, frequent hospitalizations, and baldness, they did welcome the special attention brought about by these stressors. Many of the children in the study understood the impact of their illness on the family. They felt guilty about family financial pressures, parental marital problems, and sibling conflicts that resulted from their cancer. Most feared relapse and death but hid their feelings to protect their parents. Mothers handled the stress of their child's illness by learning all they could about the disease, focusing completely on the sick child, and protecting the child from further harm. Fathers tended to take on the role of "strong one" while worrying about finances and attempting to keep the families together. Differing ways of coping between mothers and fathers often caused feelings of resentment and marital difficulties. Parental attitudes toward the staff at the medical center varied from trust, to wariness, to dependency. Parents enjoyed the support of family, friends, and community during the diagnosis phase, but felt bitter about the lack of support they received during the treatment and completion stages. Some parents believed that their exposure to the stressors of the illness process led to personal growth that they would not have experienced otherwise. Many parents emerged from the cancer ordeal with a desire to help others who were battling childhood cancer. They became involved in a variety of community agencies that served the families of children with cancer.
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Falla, Karen M. "The Relationship between Executive and Psychosocial Functioning in Children Treated for a Brain Tumor." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2848/.

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This study examined the relationship between executive and psychosocial functioning in 45 children and adolescents age 6 to 17 years who had been treated for a brain tumor. Executive functioning deficits can profoundly impact an adult's ability to function successfully in life. The purpose of the study was to evaluate the potential impact of executive functioning deficits on the day-to-day functioning in a pediatric population. The domains of executive functioning assessed included cognitive flexibility, conceptual thinking, sustained attention, and response inhibition. Psychosocial functioning was assessed using both parent and child report. Several significant relationships were found for adolescents ages 15 and older, with effect sizes ranging from medium to large. In particular, cognitive flexibility and conceptual thinking were significantly related to parent report of depression and adaptive functioning. Fewer significant relationships with smaller effect sizes were found for younger children. The results may reflect the developmental emergence of executive functioning abilities and late effects of executive functioning deficits upon psychosocial functioning. The correlational design of this study precludes definitive statements regarding the temporal nature of the relationship. Additional research, including longitudinal research and replicatory studies, will be needed to further investigate the developmental consequences of executive functioning impairment.
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Monterrubio, Martínez Carles. "Delivery of SN-38 in pediatric solid tumors." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399596.

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A new combined microdialysis – tumor homogenate method for the determination of compartmental (vascular, extra- and intracellular) SN-38 distribution in patient-derived xenografts (PDX) generated from pediatric solid tumors from fresh tumor samples from patients of Sant Joan de Deu Barcelona Hospital was developed. SN-38 in late-stage (chemoresistant) tumors presented limited distribution into the intracellular compartment while drug distribution into this compartment was significantly higher in early-stage (sensitive) models when SN-38 was administered as its prodrug irinotecan. Furthermore, two polymeric drug delivery systems were developed for the local and systemic administration of SN-38. Poly(lactic) acid electrospun nanofiber matrices with microcrystals of SN-38 were developed for the local administration of SN-38. Matrices showed maintained release of SN-38 over 48 h with local distribution and efficacy delaying tumor growth over PDX models. Dialysates showed limited SN-38 diffusion from the matrices through the tumor tissue, suggesting this therapy could only be useful for the local tumor control after successful surgery of the tumor or where only microscopic tumor seeds are left. Systemic administration of SN-38 was possible by encapsulating the drug into poly(lactic-co-glycolic) acid with polyethylene glycol nanoparticles, which were decorated with 3F8 monoclonal antibody, an anti-GD2 antibody that recognizes the ganglioside GD2 overexpressed on the surface of neuroblastoma cells surface for active targeting. Nanoparticles released SN-38 over 2 days and tumor exposition to SN-38 was increased when compared with the administration of an equimolar dose of irinotecan, and that was correlated with improved efficacy over the conventional irinotecan where 10 administrations of the drug had reduced efficacy compared to the direct administration of SN-38 in the targeted nanoparticles. Both nanofiber matrices and nanoparticles showed to be good platforms for SN-38 administration reducing systemic exposition by localizing SN-38 at the tumor microenvironment and significantly delaying tumor growth as shown in the efficacy studies. Thus, polymeric local drug delivery systems strategy should be of high interest for the potential future treatment of chemoresistant tumors.
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Chan, David Wai 1968. "The role of EWS/FLI-1 fusion gene in Ewing's sarcoma." Monash University, Institute of Reproduction and Development, 2001. http://arrow.monash.edu.au/hdl/1959.1/8307.

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Robbins, Kathryn H. "Parent-child communication about the cancer experience in families of pediatric cancer patients /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9109.

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Books on the topic "Tumors in children"

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Gajjar, Amar, Gregory H. Reaman, Judy M. Racadio, and Franklin O. Smith, eds. Brain Tumors in Children. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-43205-2.

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E, Cohen Michael, and Duffner Patricia K, eds. Brain tumors in children. Philadelphia: W.B. Saunders, 1991.

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E, Horowitz Marc, and Pizzo Philip A, eds. Solid tumors in children. Philadelphia: Saunders, 1991.

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Adler, Claus-Peter, and Kazimierz Kozlowski. Primary Bone Tumors and Tumorous Conditions in Children. London: Springer London, 1993. http://dx.doi.org/10.1007/978-1-4471-1951-7.

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Özek, M. Memet, Giuseppe Cinalli, Wirginia Maixner, and Christian Sainte-Rose, eds. Posterior Fossa Tumors in Children. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11274-9.

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Schneider, Dominik T., Ines B. Brecht, Thomas A. Olson, and Andrea Ferrari, eds. Rare Tumors in Children and Adolescents. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92071-5.

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Schneider, Dominik T., Ines B. Brecht, Thomas A. Olson, and Andrea Ferrari, eds. Rare Tumors In Children and Adolescents. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-04197-6.

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G, Ashley David, ed. Spinal tumors in children and adolescents. New York: Raven Press, 1990.

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1951-, Packer Roger J., and International Cancer Research Data Bank., eds. Childhood brain tumors. Bethesda, MD: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, International Cancer Research Data Bank, 1992.

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1918-, Brooks Benjy Frances, and Robert E. Gross Symposium (6th : 1984 : M.D. Anderson Hospital and Tumor Institute), eds. Malignant tumors of childhood. Austin: University of Texas Press, 1986.

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Book chapters on the topic "Tumors in children"

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Swischuk, Leonard E., and Siddharth P. Jadhav. "Tumors, Cysts, and Tumor Mimickers." In Emergency Musculoskeletal Imaging in Children, 19–29. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7747-1_3.

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Özek, M. Memet, and Saeed Kohan. "Dermoid Tumors." In Posterior Fossa Tumors in Children, 783–94. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11274-9_52.

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Kohan, Saeed, Joachim Oertel, and M. Memet Özek. "Epidermoid Tumors." In Posterior Fossa Tumors in Children, 795–804. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11274-9_53.

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Udaquiola, Julia E., Marcela P. Valdivieso Castro, and Israel Fernandez-Pineda. "Rare Tumors in Children: Vascular Tumors." In Pediatric Surgical Oncology, 1–25. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-71113-9_127-1.

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Kulkarni, Abhaya V., and Patrick J. McDonald. "Meningiomas in Children." In Oncology of CNS Tumors, 539–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02874-8_39.

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Yeo, Kee Kiat, and Girish Dhall. "Germ Cell Tumors." In Brain Tumors in Children, 251–64. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-43205-2_11.

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Desai, Kavita, and Michael J. Fisher. "Germ Cell Tumors." In Diabetes Insipidus in Children, 69–81. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-83248-3_6.

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Mattos, Claudia, Brandy Johnson, and Joseph Piccione. "Airway Tumors." In Diagnostic and Interventional Bronchoscopy in Children, 347–55. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-54924-4_27.

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Godzinski, Jan, Roberto Bianchi, and Marco Guzzo. "Odontogenic Tumors." In Rare Tumors In Children and Adolescents, 175–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-04197-6_20.

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Bianchi, Roberto, Jan Godzinski, and Marco Guzzo. "Laryngeal Tumors." In Rare Tumors In Children and Adolescents, 187–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-04197-6_22.

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Conference papers on the topic "Tumors in children"

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Soni, Priyanka, Shalini Mishra, Sandeep Jain, and Gauri Kapoor. "Malignant ovarian germ cell tumors in children: A single centre experience." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685314.

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Background: Germ-cell tumors (GCT) are the commonest ovarian neoplasm in the first two decades of life. Aim: To study the profile of ovarian GCT in children and their outcome. Methods: Retrospective study of all cases of malignant ovarian GCT in the pediatric age (up to 18 years) was done from January 2002 to December 2015. The medical records of all admitted cases during this period were reviewed and the data was analysed with respect to age at diagnosis, clinical presentation, tumor markers, surgical stage, tumor histology, therapy, clinical course, and outcome. Results: Girls with malignant ovarian GCT were seen at our institute during the study period. Out of these 25 underwent treatment. Mean age at presentation was 11.7 years (range: 3-18 years). Abdominal pain was the commonest presentation. Twelve (47.3%) had right sided disease, 11 (42%) had left sided disease and 2 had bilateral disease. Twelve cases (57.8%) were diagnosed as stage I disease, 5 (10.5%) as stage II, 7 (26.3%) as stage III and 1 (5.2%) as stage IV. Elevated AFP >1000 was found in 9 (47.3%), elevated B-HCG (>50) in 7 (42%) and elevated LDH (>1000) in 7 (36.8%) patients at presentation. Twenty (73.6%) patients underwent surgery prior to chemotherapy out of which 4 (21%) patients presented after undergoing surgery at other centre. Fourteen (57.8%) patients received 4 cycles of BEP based chemotherapy, 6 (21%) received 3 cycles, 2 (10.5%) received 2 cycles and 1 patient did not receive any chemotherapy as it was mature teratoma. The most common histology was dysgerminoma in 8 (42%) patients followed by mixed germ cell tumor in 4 (21%), teratoma in 3 (15.7%), embryonal carcinoma in 2 (10.5%) and yolk sac tumor and mature teratoma in 1 patient each. Four (21%) patients had relapse on contralateral side which was salvaged. 1 patient presented with relapse who underwent only surgery outside, 1 patient had ovarian torsion. Median follow up is 27months. The event free survival rate was 78.9%. Conclusion: This study confirms an excellent outcome for girls with ovarian germ cell tumor. Patients with advanced surgical stage relapsed frequently. The mainstay of treatment is fertility preserving surgery and cisplatin-based chemotherapy.
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Hood, R. Lyle, Tobias Ecker, John Rossmeisl, John Robertson, and Christopher G. Rylander. "Improving Convection-Enhanced Delivery Through Photothermal Augmentation of Fluid Dispersal." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80720.

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Malignant tumors of the central nervous system are the third leading cause of cancer-related deaths in adolescents and adults between the ages of 15 and 34; in children, brain tumors are the leading cause of cancer death. Convection-enhanced delivery (CED) has emerged as a promising method for the transport of high concentrations of chemotherapeutic macromolecules to brain tumors. CED is a minimally-invasive surgical procedure wherein a stereotactically-guided small-caliber catheter is inserted into the brain parenchyma, to a tumor site, for low flowrate infusion of chemotherapy [1]. This direct-delivery method bypasses obstacles to systemic chemotherapy caused by the selective impermeability of the blood-brain barrier. Although preliminary studies were favorable, CED recently failed Phase III FDA trials because clinical goals for tumor regression were not met [2]. This was primarily attributed to insufficient diffuse delivery of the drug throughout tumor masses and their surrounding margins.
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Jaimes, Camilo, and Michael Burt. "Posterior fossa tumors in children: radiographics & radiogenomics." In Radiopaedia 2023. Radiopaedia.org, 2023. http://dx.doi.org/10.53347/rposter-1666.

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Shaji, Thejus, K. Ravi, E. Vignesh, and A. Sinduja. "Brain Tumor Segmentation Using Modified Double U-Net Architecture." In International Research Conference on IOT, Cloud and Data Science. Switzerland: Trans Tech Publications Ltd, 2023. http://dx.doi.org/10.4028/p-52096g.

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Children and the elderly are most susceptible to brain tumors. It's deadly cancer caused by uncontrollable brain cell proliferation inside the skull. The heterogeneity of tumor cells makes classification extremely difficult. Image segmentation has been revolutionized because of the Convolution Neural Network (CNN), which is especially useful for medical images. Not only does the U-Net succeed in segmenting a wide range of medical pictures in general, but also in some particularly difficult instances. However, we uncovered severe problems in the standard models that have been used for medical image segmentation. As a result, we applied modification and created an efficient U-net-based deep learning architecture, which was examined on the Brain Tumor dataset from the Kaggle repository, which consists of over 1500 images of brain tumors together with their ground truth. After comparing our model to comparable cutting-edge approaches, we determined that our design resulted in at least a 10% improvement, showing that it generates more efficient, better, and robust results.
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Abushkin, I. A., A. G. Denis, I. S. Vasiliev, A. V. Lappa, V. A. Privalov, O. A. Gavrilova, V. O. Lapin, O. A. Romanova, and M. Y. Galiulin. "Laser Thermotherapy of Vascular Tumors in Children under Ultrasound Control." In 2018 International Conference Laser Optics (ICLO). IEEE, 2018. http://dx.doi.org/10.1109/lo.2018.8435195.

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Zhelezny, P. A., M. A. Sadovoy, I. A. Kirilova, S. P. Zhelezny, B. T. Podorozhnaya, and A. P. Zheleznaya. "Bone alloplasty and rehabilitation of children with maxillo-facial tumors." In PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17). Author(s), 2017. http://dx.doi.org/10.1063/1.5001663.

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Alekseeva, Olga, and Julia Burdukova. "CHEMOTHERAPY EFFECT ON SHORT-TERM MEMORY IN CHILDREN WITH BRAIN TUMORS." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2029.sudak.ns2021-17/53-54.

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de Kock, Leanne, Barbara Rivera Polo, Mona Wu, Evan Weber, Claudio Sandoval, Saskia M. J. Hopman, J. Hans M. Merks, et al. "Abstract 4934: Mosaic RNase IIIb domainDICER1mutations in children with multiple primary tumors." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4934.

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Cash, Thomas, Dolly Aguilera, Margaret E. Macy, Lindsey Hoffman, Kathleen Dorris, Courtney McCracken, Bradley Hanberry, Robert Castellino, Tobey MacDonald, and Cynthia Wetmore. "Abstract C002: Phase 1 study of abemaciclib in children with recurrent and refractory solid tumors including malignant brain tumors." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-c002.

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Silveira, Emily Santos da, Guilherme Requião Radel Neto, Julia Souza e. Costa, and César de Carvalho Garcia. "Resection of low-grade temporal gliomas and the improvement of convulsive seizures." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.479.

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Introduction: Epilepsy is a neurological disorder marked by recurring seizures, and secondary epilepsy refers to seizures that are generated by an underlying medical condition or injury. Low-grade temporal gliomas (LGTGs) frequently have epileptogenic potential, causing seizures. Tumor resection is often the preferred treatment when timing and compatibility with the patient and tumor attributes are determined. Objectives: To discuss the main factors in the medical literature relevant to the improvement of seizures by resection of LGTGs and their surgical features. Methods: A literature review was performed within the PubMed database, using the keywords “low-grade gliomas”, “low-grade tumors”, “resection”, “seizures” and “epilepsy”. Publications from 2010 to 2023 were included. Results: Studies point out that gross full extension resection of LGTGs to achieve seizure freedom results in superior positive outcomes when compared to partial resection for Engel class I patients. Of the patients who had a partial resection, memory deficits were frequent. In addition, recurring epilepsy related to lowgrade tumors and the time span of epilepsy were reported to be higher in children than in adults. Postoperative outcomes of patients with mesial temporal lobe lesions outperformed those with lateral temporal tumors. The addition of hypocampectomy and/or corticectomy of the anterior temporal lobe further improved the seizure freedom rate when compared to gross total lesionectomy. Conclusion: Gross total resection of LGTGs provides a more favorable outcome than partial resection. After surgery, the seizure freedom rate is high (> 70%), and resection type is a significant predictor of seizure recurrence. Subtotal resection has a lower seizure-free rate compared to total lesionectomy, with additional benefits seen from hypocampectomy and/or corticectomy of the anterior temporal lobe. Tumor pathology or laterality did not significantly predict seizure freedom.
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Reports on the topic "Tumors in children"

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Cao, Xianling, Xuanyou Zhou, Naixin Xu, Songchang Chang, and Chenming Xu. Association of IL-4 and IL-10 Polymorphisms with Preterm Birth Susceptibility: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0044.

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Review question / Objective: The aim of our systematic review and meta-analysis was to summarize the effects of IL-4 and IL-10 gene polymorphism and clarify their possible association with PTB. Condition being studied: World Health Organization (WHO) defines preterm birth (PTB) as babies born alive before 37 weeks of pregnancy are completed. The new estimates show that the prevalence of PTB during 2014 ranged from 8.7% to13.4% of all live births, about 15 million preterm babies born each year. Besides, PTB is the leading cause of death worldwide for children below 5 years of age. Babies born preterm are at an increased risk of short-term and long-term complications attributed to immaturity of multiple organ systems, such as cerebral palsy, intellectual disabilities, vision and hearing impairments, and impaired cognitive development. PTB has become a worldwide public health problem, but its etiology remains unclear. Accumulating evidence shows that PTB is a syndrome that can be attributed to a variety of pathological processes(5). Inflammatory diseases and genetic background are known risk factors for PTB, many studies had shown that genetic variations in proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1 α (IL-1 α) are associated with increased risk of PTB, but the relationship between genetic polymorphism in anti-inflammatory cytokines and risk of PTB remains controversial.
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Surendra G, Dr Prasad, Dr Bhuyan Ashok K, Dr Baro Abhamon, Dr Saikia Uma K, and Dr Kumar Angad. CLINICAL AND METABOLIC CHARACTERISTICS OF PRIMARY HYPERPARATHYROIDISM IN DIFFERENT AGE GROUPS- A TERTIARY CENTRE EXPERIENCE. World Wide Journals, February 2023. http://dx.doi.org/10.36106/ijar/6005490.

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Background and Objectives- Symptomatic Primary Hyperparathyroidism (PHPT) is common in India in comparison to the western population. But there is very little data on the inuence of age on the presentation of PHPT. In the present study we aimed to analyse the clinical and metabolic prole among different age groups of symptomatic primary hyperparathyroidism. Methods: This retrospective analysis was done in PHPT patients who attended Department of Endocrinology, Gauhati Medical college and Hospital. Thirty-one PHPT subjects who presented to us over a period of last ve years were divided into three different age groups i.e, children and adolescents <18yrs, adults ≥18-50 years, and older group >50years. All major clinical, metabolic and imaging parameters were compared among these groups. Appropriate statistical methods were used to compare different variables. The age distribution ranged from 13 to Results: 72 years with mean age of 38.6±16.3years and with equal female to male ratio. Bony deformity (Rickets) as initial manifestation was seen in three adolescents and bone pain was common in adolescents(p=0.05). Prevalence of renal stones were higher in adult group(p=0.002), gastrointestinal manifestations were higher in older group (p=0.02). There was no signicant difference in fracture rate(P=0.17), brown tumours(P=0.56) and other symptoms among different age groups. Alkaline phosphatase(p=0.006) and iPTH(p=0.01) were signicantly higher in adolescent group. There was no signicant difference in serum calcium, phosphate, 25(OH)Vitamin-D3 and haemoglobin levels among different age groups. Age has substantial inuence on PHPT presentation. Bone Interpretation & Conclusion: pain and deformity was common in adolescents, while renal stones and gastrointestinal manifestations were common in middle aged and elderly group respectively
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