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Journal articles on the topic 'Tumor'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Mathew, George, and Shwetha Jose. "PRIMARY TUMORS AND TUMOR-LIKE LESIONS OF BONE IN CHILDREN." International Journal of Integrative Medical Sciences 4, no. 6 (November 3, 2017): 507–11. http://dx.doi.org/10.16965/ijims.2017.112.

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Légrádi, Mária, Jenő Mojzes, Endre Kálmán, Evelin Csernus, and Zita Battyáni. "Abrikossoff`s tumor – Granular cell tumor." Bőrgyógyászati és Venerológiai Szemle 88, no. 2 (April 30, 2012): 56–59. http://dx.doi.org/10.7188/bvsz.2012.88.2.4.

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Rodin, William Carl Ivar, Patrik Sundström, Filip Ahlmanner, Elinor Bexe Lindskog, and Marianne Quiding Järbrink. "Potent anti-tumor effector functions in tumor-infiltrating MAIT and γδ T cells isolated from colon cancer patients." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 138.13. http://dx.doi.org/10.4049/jimmunol.202.supp.138.13.

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Abstract In colon cancer, tumor progression and patient outcome is affected by the cytokine balance in the tumors. IFNγ, TNFα and Granzyme B expression are associated with favorable patient outcome, while high IL-17 expression is associated with accelerated tumor progression. However, knowledge of the regulation and activation of unconventional T cell subsets in colon tumors is limited. The aim of this study was to characterize unconventional T cells in colon tumors and unaffected tissue, determine their capacity to produce cytokines affecting tumor progression as well as the In vitro cytotoxic capabilities of MAIT and γδ T cells. Using flow cytometry, we show that MAIT cells accumulate in colon tumors and that the frequencies of γδ T cells are reduced in the tumor epithelium. Using polyclonal stimulation, we show that IFNγ production by tumour infiltrating MAIT cells is impaired whilst tumour infiltrating γδ T have an increased expression of IFNγ, TNFα and Granzyme B. IL-17 expression was also elevated in tumour infiltrating γδ T cells, but at lower levels than the TH1 - associated cytokines. Tumor infiltrating MAIT cells had an exhausted (PD-1highTim-3+) phenotype compared to MAIT cells from unaffected tissue. Analyzing cytokine expression, we show that while no single molecule is lost the polyfunctional capacity of tumour infiltrating MAIT cells is decreased compared to MAIT cells from unaffected tissue. Altogether, this study shows that γδ T cells and MAIT cells contribute to the cytokine balance in colon tumors with a TH1 – dominated profile and that they have potent cytotoxic capacity, which may reduce tumor progression and improve patient outcome.

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Patel, Falguni T., Bhoomi A. Shah, Nisarg R. Parikh, and Ratigar N. Gonsai. "Steroid cell tumor : A rare ovarian tumor." Annals of Pathology and Laboratory Medicine 6, no. 8 (August 26, 2019): C88–90. http://dx.doi.org/10.21276/apalm.2500.

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Raheja, Aastha, Deepti Goswami, Pooja Sakhija, Gauri Gandhi, and Bidhisha Singhla. "Steroid Cell Tumor: A Rare Ovarian Tumor." Annals of Applied Bio-Sciences 5, no. 2 (June 2018): C1–3. http://dx.doi.org/10.21276/aabs.2167.

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Sengupta, Sanjay, Subrata Pal, Biplab Kr Biswas, Srabani Chakrabarti, Kingshuk Bose, and Sritanu Jana. "Collision tumor of ovary: a rare combination of dysgerminoma and serous cystadenocarcinoma." Bangladesh Journal of Medical Science 13, no. 2 (March 3, 2014): 224–27. http://dx.doi.org/10.3329/bjms.v13i2.14955.

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Collision tumors of ovary are rare neoplasms and most commonly consist of a teratoma with mucinous tumor. Combination of papillary serous cystadenocarcinoma and dysgerminoma was yet to be reported. A twenty years female patient presented with a large tumor of right ovary. Microscopically it was diagnosed as a collision tumor of ovary composed of dysgerminoma and serous cystadenocarcinoma. Mixed tumour can arise from divergent differentiation of a single type of stem cell. But components of collision tumor must arise from separate clones. Possibility of collision tumour should always kept in mind during assessment of difficult ovarian tumors to avoid diagnostic error. DOI: http://dx.doi.org/10.3329/bjms.v13i2.14955 Bangladesh Journal of Medical Science Vol.13(2) 2014 p.224-227

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Milas, L. "Tumor Bed Effect in Murine Tumors: Relationship to Tumor Take and Tumor Macrophage Content." Radiation Research 123, no. 2 (August 1990): 232. http://dx.doi.org/10.2307/3577551.

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Punam, Saudagar. "Deep Learning Approach for Brain Tumor Classification." International Journal for Research in Applied Science and Engineering Technology 9, no. VI (June 30, 2021): 3094–98. http://dx.doi.org/10.22214/ijraset.2021.35648.

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Tumors are complex. There are a lot of variations in sizes and location of tumor. This makes it really hard for complete understanding of tumor. Brain tumour is the abnormal growth of cells inside the brain cranium which limits the functioning of brain. Now a days, medical images processing is a most challenging and developing field. Automated detection of tumor in MRI is extremely crucial because it provides information about abnormal tissues which is important for planning treatment. The conventional method for defect detection in resonance brain images is time consuming. So, automated tumor detection methods are developed because it would save radiologist time and acquire a tested accuracy. The MRI brain tumor detection is complicated task due to complexity and variance of tumors.There are many previously implemented approaches on detecting these kinds of brain tumors. In this paper, we used and implement Convolutional Neural Network (CNN) which is one among the foremost widely used deep learning architectures for classifying a brain tumor into four types. i.e Glioma , Meningioma, Pituitary and No tumour. CNN may be used to effectively locate most cancers cells in brain via MRI. classification.

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Malik, Shan Nawaz, Mohammad Khursheed Alam, Mariyam Shahina, Salman Siddique, and Vishnu Das Prabhu. "Calcifying Epithelial Odontogenic Tumor (Ceot)." Bangladesh Journal of Medical Science 13, no. 1 (December 24, 2013): 14–19. http://dx.doi.org/10.3329/bjms.v13i1.17378.

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Calcifying epithelial odontogenic tumor is a rare benign epithelial odontogenic lesion that comprises from 0.2% to 1.1 of all odontogenic tumors. In the past a number of different names have been given to this lesion, such as calcifying ameloblastoma, cystic complex odontoma, uncommon ameloblastoma with calcifications and others. There is a need to study and explore various aspects of this tumour, this article gives a broad idea of the various aspects of this tumor and which aspect of this tumour needs more investigation. DOI: http://dx.doi.org/10.3329/bjms.v13i1.17378 Bangladesh Journal of Medical Science Vol. 13 No. 01 January2014: 14-19

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Barreda Bolaños, Fernando, Humberto Liu Bejarano, Lidia Rodriguez Briceño, Bruno Salmon Alva, Edith Sulca Flores, Luis Taxa Rojas, and Francisco Berrospi Espinoza. "Tumor sólido pseudopapilar de páncreas: Tumor de Frantz." Horizonte Médico (Lima) 18, no. 2 (December 31, 2018): 80–85. http://dx.doi.org/10.24265/horizmed.2018.v18n2.12.

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Kim, Dong-Ju, Lee-Chan Jang, Jae-Woon Choi, and Jin-Woo Park. "Retroperitoneal Tumors Mimicking Adrenal Tumor." Korean Journal of Endocrine Surgery 12, no. 1 (2012): 31. http://dx.doi.org/10.16956/kjes.2012.12.1.31.

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12

Millichap, J. Gordon, and John J. Millichap. "Tumors and Tumor-Related Epilepsy." Pediatric Neurology Briefs 28, no. 2 (February 1, 2014): 9. http://dx.doi.org/10.15844/pedneurbriefs-28-2-1.

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Eriksson, Barbro, Kjell Öberg, and Mats Stridsberg. "Tumor Markers in Neuroendocrine Tumors." Digestion 62, no. 1 (2000): 33–38. http://dx.doi.org/10.1159/000051853.

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Shivdikar, Adish, Mihir Shirke, Ishwar Vodnala, and Prof Jaychand Upadhaya. "Brain Tumor Detection using Deep Learning." International Journal for Research in Applied Science and Engineering Technology 10, no. 3 (March 31, 2022): 621–27. http://dx.doi.org/10.22214/ijraset.2022.40710.

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Abstract: Tumors are now the second major cause of cancer. A huge percentage of patients are in danger as more than just a consequence of cancer. The medical field needs fast, automated, efficient and reliable technique to detect tumor like brain tumor. Detection plays very important role in treatment. If proper detection of tumor is possible then doctors keep a patient out of danger. Various image processing techniques are used in this application. Doctors are able to provide excellent treatment and save a huge number of tumour patients by using this application. A tumour is nothing more than an uncontrolled growth of cells. Brain tumour cells expand to the point where they consume all of the nutrition intended for healthy cells and tissues, resulting in brain failure. Currently, doctors manually locate the position and area of a brain tumour by looking at the patient's MR images of the brain. This leads to inaccuracy in tumour detection and is extremely time intensive. A tumour is an uncontrollably growing clump of tissue. We can utilise CNN (Convolution Neural Network), also known as NN (Neural Network), and VGG 16 Deep Learning architectures (visual geometry group). To diagnose a brain tumour, transfer learning is used. The model's performance predicts whether or not a tumour is present in an image. If a tumour is present, the answer is yes; otherwise, the answer is no. Keywords: Brain Tumor, MRI, OpenCV, Data Augmentation, CNN, Transfer learning, VGG.

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Chaudhary, Pramod, Sunil Munakomi, Narendera Joshi, Babita Khanal, and Prakash Kafle. "Spectrum of Central Nervous System Tumours at Tertiary Care Centre in Nepal." Journal of College of Medical Sciences-Nepal 18, no. 1 (March 31, 2022): 66–73. http://dx.doi.org/10.3126/jcmsn.v18i1.40623.

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IntroductionMost of the Central Nervous System tumors are benign. There is increase in the incidence in recent days which might be due to improved diagnosis with advancement in the ancillary studies. This study aims to provide a single centre histopathological spectrum of tumor of CNS. MethodsThis is a retrospective cross-sectional study of 138 cases of CNS tumors managed surgically in the department of neurosurgery from 2017 to 2020.All the histological subtypes and grading were reviewed. Data of the study population were analysed using SPSS version 25 and Microsoft excel. All the patients were classified as per the 2007 World Health Organization classification of central nervous system tumors. ResultsA total of 138 cases were analysed.One hundred and thirteen constitutes brain tumors and remaining 25 constitute the spinal tumors. Of the total cases, 132 were primary CNS tumor and remaining six were secondary CNS tumor. In cranial, 61 (44.2%) were extra axial tumors. There were 122 low grade tumor and remaining 16 were high grade tumors. Tumors of neuroepithelial origin were the most common 54 (38.9%) CNS tumors followed by meningiothelial tumors 36 (26.0%).Tumor were equally distributed in both the sex.Mean age of study population was 37.38 years ranging from 0.5 years to 75 years. ConclusionsThe present study concludes that the most common CNS tumour at our centre were neuroepithelial tumor mainly pilocytic astrocytoma followed by meningothelial.

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Nelson, Delia, Scott Fisher, and Bruce Robinson. "The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment." Journal of Immunology Research 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/789069.

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Most anticancer therapies including immunotherapies are given systemically; yet therapies given directly into tumors may be more effective, particularly those that overcome natural suppressive factors in the tumor microenvironment. The “Trojan Horse” approach of intratumoural delivery aims to promote immune-mediated destruction by inducing microenvironmental changes within the tumour at the same time as avoiding the systemic toxicity that is often associated with more “full frontal” treatments such as transfer of large numbers of laboratory-expanded tumor-specific cytotoxic T lymphocytes or large intravenous doses of cytokine. Numerous studies have demonstrated that intratumoural therapy has the capacity to minimizing local suppression, inducing sufficient “dangerous” tumor cell death to cross-prime strong immune responses, and rending tumor blood vessels amenable to immune cell traffic to induce effector cell changes in secondary lymphoid organs. However, the key to its success is the design of a sound rational approach based on evidence. There is compelling preclinical data for local immunotherapy approaches in tumor immunology. This review summarises how immune events within a tumour can be modified by local approaches, how this can affect systemic antitumor immunity such that distal sites are attacked, and what approaches have been proven most successful so far in animals and patients.

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Zenukova, Tat’yana V., A. G. Perevoschikov, D. V. Kuzmichev, and Yu A. Barsukov. "The indicators of the tumour proliferative activity and therapeutic responsiveness in adenocarcinoma in anal canal after complex treatment." Russian Journal of Oncology 19, no. 5 (October 15, 2014): 42–46. http://dx.doi.org/10.17816/onco40119.

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Carcinoma of the anal canal is infrequent pathology. The morbidity registers in 5,2% among men and 4,8% among women. The purpose of this study was investigated the correlation among morphological characteristics of the tumors. Tumor regression grade and index Ki 67 are morphological indicators of the effectiveness of the complex treatment. In the 47,5% (n = 19) of both groups was exposed I-II tumour regression grade, IV tumour regression in grade 3,3 % (n = 2). Tumor regression grade positively correlated with the degree of the tumor invasion (coeff.corr. = +0,47) (p > 0.05).

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Pauser, U., N. Schmedt Auf Der Günne, M. Anlauf, C. Capella, M. Marichal, and G. Klöppel. "Regulation of tumor proliferation and tumor differentiation in gastrointestinal stroma tumors." Pathology - Research and Practice 200, no. 4 (January 2004): 316. http://dx.doi.org/10.1016/s0344-0338(04)80631-9.

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Khochare, Gaurav G., Shantanu S. Khopade, Pratik N. Khinde, Sachi D. Khobragade, and Sampada R. Khopade. "Brain Tumor Diagnosis Using CNN and Image Processing." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (June 30, 2023): 2042–47. http://dx.doi.org/10.22214/ijraset.2023.53922.

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Abstract: Among the most tedious and time-consuming tasks in medical image processing is brain tumor identification and segmentation. Magnetic resonance imaging, or MRI, is a medical procedure that radiologists primarily utilize to examine the human body without having to do surgery. The substantial information that MRI provides on human soft tissue aids in the diagnosis of brain tumors. It is crucial to accurately segment MRI images in order to detect a brain tumour utilizing computeraided clinical techniques. Brain tumor identification facilitates determining the precise size and location of the tumor. Initially, the scanned image's quality is upgraded, and tumors are located in the image using morphological operators

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González Vester, Ricardo Javier, and Sergio Adrián Barreto Román. "Tumor de Testículo." Revista del Nacional (Itauguá) 15, no. 2 (December 29, 2023): 89–92. http://dx.doi.org/10.18004/rdn2023.dic.02.089.092.

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Introducción: los tumores testiculares representan el 4% de las neoplasias urogenitales, de las cuales el seminoma es el tumor maligno más frecuente del testículo en los varones jóvenes. El pronóstico es bueno con la orquiectomía total, llegando a una sobrevida del 95% en 10 años. Presentación de Caso: paciente de sexo masculino de 28 años con tumoración no dolorosa en región escrotal de 10 años de evolución, acude al servicio de urología por molestias y aumento importante de la tumoración en el último año. Conclusión: el tumor testicular tiene un muy buen pronóstico si es detectado a tiempo, teniendo en cuenta que con la exploración física ya se puede tener el diagnostico.

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Wiratnaya, I. Gede Eka, and Risang Haryo Raditya. "Bone tumor wide excision due to giant cell tumor of proximal humerus." International journal of health & medical sciences 6, no. 3 (September 29, 2023): 201–3. http://dx.doi.org/10.21744/ijhms.v6n3.2199.

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Introduction: Giant Cell Tumors are benign, aggressive tumors typically found in the epiphysis of long bones. It has a potential for aggressive behaviour and the capacity to metastasize. the most common symptom of a giant cell tumor is a pain in the area of the tumor. The patient may also have pain with the movement of the nearby joint. Case: We reported an 18-year-old boy with an extensive giant-cell tumor of proximal humerus. Radiograph show a primary malignant bone tumour proximal humerus dextra with soft tissue swelling. There was a lytic lesion, with wide zone transition on proximal humerus dextra, and a trabeculated bone outside the normal lesion was treated by segmental resection and shoulder reconstruction. A prosthesis was used to reconstruct the shoulder joint, the rotator cuff was reattached to the bone after making a semicircular trough. Discussion: There are several therapy options for the patient, the non-operative and operative therapy. The non-operative way such as radiation therapy, medication therapy, and tumor embolization. The operative way such as extensive, complete resection, and amputation. Conclusion: Wide excision is suitable for this patient, we can save normal tissue and do some shoulder reconstruction.

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Kumar, Raju, Rana Ibrahim, Bassem Ben Cheikh, Emma Bailey, Hannah Cottom, Oliver Braubach, Trevor Graham, Jun Wang, and Ines Sequeira. "Abstract 5629: Spatial genomics and proteomics enable multimodal analyses of oral SCC clonal heterogeneity and interactions with tumor microenvironment." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5629. http://dx.doi.org/10.1158/1538-7445.am2023-5629.

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Abstract Cancer progression is an evolutionary process governed by the clonal evolution of the genetic mutations acquired during tumor growth, together with the co-evolution of the tumour ecosystem. The nature of cancer subclonal mutations and their effects on the tumour microenvironment are the major drivers of intratumor heterogeneity and contribute to cancer progression, metastasis, therapy resistance and disease recurrence. Therefore, a spatially resolved genetic and cellular profiling of tumors is crucial to investigate tumor architecture and cellular diversity. Oral squamous cell carcinoma (OSCC), a subset of head and neck cancer, accounts for 355,000 new cases annually worldwide and has a 5-year survival rate of only 50%. We recently conducted a multi-level analysis of OSCC genetic and microenvironment heterogeneity (Sequeira et al, 2020, NatComms). Computational analysis of tumour clonal dynamics from DNA sequencing data revealed that high genetic heterogeneity to be a feature of early-stage lesions that are likely to progress to more aggressive tumors (Williams et al 2018, NatGen; Sequeira et al, 2020, NatComms). These tools can be used to predict tumour behavior and for early diagnosis of aggressive lesions. The goal of this study is to elucidate the functional and spatial intratumor heterogeneity, tumor clonal dynamics and evolutionary landscape of human OSCC, and to study the interaction of tumour cells with the microenvironment, in particular the role of specific mutations in promoting epithelial-to-mesenchymal transition and tumor progression, using an interdisciplinary approach that combines spatial integrative genome analysis and deep single-cell phenotyping of tumor microenvironment. We performed whole-exome sequencing from multifocal OSCC tumor regions and matched metastasis, and used computational methods to investigate the tumor subclonal organization, construct phylogenetic trees for each tumor and assess the genetic diversity of the different tumour regions and metastasis. We then combined Single cell Spatial Phenotyping on the PhenoCycler platform (Akoya Biosciences) (Black et al, 2021, NatProtocols) with the subclonal genomic analysis to investigate how different mutational landscapes affect tumor microenvironment and metastasis, at unprecedented detail. Together, this multi-modal integrated spatial genomics and proteomics analysis of the tumor ecosystem highlights the importance of spatial cellular organization and provides a comprehensive human OSCC spatial atlas of tumour heterogeneity, providing a foundation for exploring cancer evolution, heterogeneity and progression. Citation Format: Raju Kumar, Rana Ibrahim, Bassem Ben Cheikh, Emma Bailey, Hannah Cottom, Oliver Braubach, Trevor Graham, Jun Wang, Ines Sequeira. Spatial genomics and proteomics enable multimodal analyses of oral SCC clonal heterogeneity and interactions with tumor microenvironment. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5629.

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Kumavat, Prashant Vijay, Nitin Gadgil, Chetan Chaudhari, Ujwal Rathod, Ganesh Kshirsagar, and Sangita Margam. "Bone Tumors and Tumor-like lesions: A study in a Tertiary Care Hospital, Mumbai." Annals of Pathology and Laboratory Medicine 4, no. 1 (January 2017): A10—A18. http://dx.doi.org/10.21276/apalm.2017.972.

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Shaw, Kaveri, Smitha Ch, and Jagdishwar Goud G. "Management of ovarian tumors." Journal of Medical and Scientific Research 2, no. 2 (April 2, 2014): 119–24. http://dx.doi.org/10.17727/jmsr.2014/2-021.

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Border line ovarian tumors are one of the common asymptomatic tumors in young women. They are mostly diagnosed at the time of routine examination. The management of tumor is crucial, since fertility preservation is a challenge in this age group. A fine balance needs to be drawn between maximal removal of tumour and preserving fertility till her reproductive needs are fulfilled. Therefore a clear idea for management will help in individual management. Surgery is the treatment of choice, but fertility preservation with close 3-6 monthly follow up is appropriate till woman completes her family. Keywords: Border line ovarian tumor; Molecular genetics; Staging of ovarian tumor

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Imran, Farrah-Hani, Nabilah Hasna Imami, and Adzim Poh Yuen Wen. "Rare Diagnosis of a Proliferating Pilar Tumor in a Facial Hairline Cryst." Folia Medica Indonesiana 58, no. 1 (March 7, 2022): 56. http://dx.doi.org/10.20473/fmi.v58i1.14562.

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Highlight:Sebaceous cyst or epidermoid cyst is a benign capsulated tumour on the scalp region, face, neck, and trunk that subepidermal nodule filled with keratin.Proliferating Pilar Tumours (PPT) are rare tumours was found in hair follicle.Sebaceous cyst diagnose on facial hairline tumour turned out to be a rare Proliferating Pilar Tumour (PPT). Abstract:Sebaceous cyst, also known as an epidermoid cyst, is a subepidermal nodule filled with keratin and it is a benign capsulated tumor. It is often located on the scalp region, face, neck, and trunk; but can be found elsewhere such as the scrotum, genitalia, fingers, and buccal mucosa. Proliferating Pilar Tumors (PPT) are rare tumors. It is derived from the external root sheath of the hair follicle. These tumors are like irregular subcutaneous nodules and often appear on the scalp. This case report was about a 59 years old woman who came to the hospital following excision of a frontal lump elsewhere, with a sebaceous cyst as the initial diagnosis. From the histopathologic examination, grossly there was a whitish and greyish lump with a soft outer surface. Microscopically, there were malignancy signs with areas with keratinization. The tumor formed a solid pattern of enlarged cells with moderate to marked nuclear pleomorphism with vesicular nuclei, prominent nucleoli, and abundant pale eosinophilic to clear cytoplasm. There was also much free keratinous debris noted and numerous foci of calcification identified within the tumor. Mitotic figures with abnormal forms were frequently seen. The final diagnosis after the histopathological examination was Proliferating Pilar Tumour with focal malignancies. In conclusion, facial hairline tumor differentially diagnosed as a sebaceous cyst turned out to be a rare Proliferating Pilar Tumor (PPT). Following histopathological confirmation, the patient was referred for further management by a specialist team.

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Robinson, Bruce W. S., Alison M. McDonnell, Matthew Brown, Amy C. Prosser, Ivonne van Bruggen, and Andrew J. Currie. "Tumor antigen cross-presentation by tumor dendritic cells is blocked at a post-processing stage but can be reversed by selected pro-apoptotic agents (88.23)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 88.23. http://dx.doi.org/10.4049/jimmunol.182.supp.88.23.

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Abstract Cross presentation defines the unique capacity of an antigen presenting cell (APC) to present exogenous antigen via MHC class I molecules to CD8+ T cells. This process serves a critical role in host anti-tumor immunity. Dendritic cells (DC), specifically the CD8α+ subset, are specialised cross-presenting cells; however there is little understanding of how different DC subsets contribute to anti-tumour immunity. In this study we have examined the cross-presentation of a marker tumour antigen (transfected HA) expressed by the murine AB1-HA cell line. We have found that tumor antigen is constitutively cross-presented in the draining lymph node throughout disease progression and that both CD8α+ and CD8α - DC subsets are responsible for the observed cross-presentation of HA antigen to CD8+ T cells. Interestingly, tumor-infiltrating DCs fail to cross present, though they are not deficient in tumor antigen uptake or processing. Importantly, a tumor apoptosis-inducing false nucleotide agent, gemcitabine, which primes for anti-tumor immunity, also reverses the defect in antigen cross presentation of tumor DCs. These data suggest that lymph node resident CD8α+ DC are not the sole DC subset capable of cross-priming against tumor antigens and that local cross-presentation within tumors ie. TCR restimulation of tumor-infiltrating CD8 T-cells may be essential for effective anti-tumor immunity. These data have important implications for tumor immunotherapy particularly the use of immunotherapy in conjunction with tumor apoptosis-inducing therapy.

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Syed, Sohail, David I. Karambizi, Amanda Baker, Darren M. Groh, and Steven A. Toms. "A Comparative Report on Intracranial Tumor-to-Tumor Metastasis and Collision Tumors." World Neurosurgery 116 (August 2018): 454–63. http://dx.doi.org/10.1016/j.wneu.2018.04.109.

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Whiteside, Theresa L., Sylvia Miescher, H. R. MacDonald, and V. Von Fliedner. "Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors." Journal of Immunological Methods 90, no. 2 (June 1986): 221–33. http://dx.doi.org/10.1016/0022-1759(86)90079-7.

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de Visser, Karin E. "Spontaneous immune responses to sporadic tumors: tumor-promoting, tumor-protective or both?" Cancer Immunology, Immunotherapy 57, no. 10 (March 15, 2008): 1531–39. http://dx.doi.org/10.1007/s00262-008-0501-x.

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Easter, Stephanie L., Elizabeth H. Mitchell, Sarah E. Baxley, Renee Desmond, Andra R. Frost, and Rosa Serra. "Wnt5a Suppresses Tumor Formation and Redirects Tumor Phenotype in MMTV-Wnt1 Tumors." PLoS ONE 9, no. 11 (November 17, 2014): e113247. http://dx.doi.org/10.1371/journal.pone.0113247.

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S, Dr Raghupathi. "Proliferating Trichilemmal Tumor." Journal of Medical Science And clinical Research 05, no. 03 (March 8, 2017): 18625–27. http://dx.doi.org/10.18535/jmscr/v5i3.58.

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Kurt, Robert A., Musea Chang, Katherine Ellmaker, Abigail Esposito, Sophea Pa, and Meghan Roberts. "Tumor-associated macrophages found at early tumor sites exhibit altered metabolism and contribute to tumor progression." Journal of Immunology 208, no. 1_Supplement (May 1, 2022): 61.11. http://dx.doi.org/10.4049/jimmunol.208.supp.61.11.

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Abstract Previously, we reported that macrophages at early tumor sites, before the tumors are even palpable, have a mixed phenotype with production of both pro- and anti-inflammatory cytokines, decreased production of reactive oxygen species, and increased dependence on oxidative phosphorylation. Here we show that depleting these tumor associated macrophages (TAM) impacted subsequent growth of the EMT6 tumor and metastasis of the 4T1 tumor supporting the contention that macrophages found at early tumor sites contribute to later stages of tumor progression. Since these TAM could not be clearly defined as M1 or M2 we set out to characterize them further focusing on their metabolism. We found that TAM present at early sites of 168, EMT6 and 4T1 tumors had elevated expression of pkm2, glut1 and ampk, and transwell assays revealed that these tumors could induce expression of pkm2, glut1 and ampk in bone marrow derived macrophages. Since tumor-derived lactate is known to induce alterations in white blood cells we investigated lactate production by these tumors and whether lactate could induce expression of these same genes. The data revealed that the 168, EMT6 and 4T1 tumors produced significant amounts of lactate and that lactate induced expression of pkm2, glut1 and ampk in bone marrow derived macrophages. Finally, we found that targeting lactate dehydrogenase or eIF2 at early tumor sites impacted growth of the EMT6 tumor, and targeting AMPK or GCN2 impacted metastasis of the 4T1 tumor. Collectively, these data support the contention that alterations in macrophages are already present at the early stages of tumor growth, before a tumor is even palpable, and that targeting metabolism at these early tumor sites can impact later stages of tumor progression.

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Viswanathan, Vidya, Harsh Kumar, Charusheela Gore, Shrikant Kurhade, and Rumaanah Khan. "A Rare Case of Mixed Ductal Neuroendocrine Tumor of the Pancreas." Annals of Pathology and Laboratory Medicine 8, no. 2 (February 28, 2021): C20–24. http://dx.doi.org/10.21276/apalm.2946.

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Collision tumors are tumors that have at least two types of tumors in the same anatomical site with no area of mixing within the transition zone. In 2010 WHO classification of neuroendocrine tumors consists of an adenocarcinoma component and a neuroendocrine carcinoma component in which each of the components accounts for 30% of the tumor. Such tumors are defined as mixed adenoneuroendocrine carcinomas. Occurrence of exocrine and endocrine tumors of the pancreas is extremely rare. The aim of our study was to describe a case in a 60 years old male who was diagnosed with this rare tumor. Gross, microscopic features and immunohistochemistry were used to diagnose this rare condition. Immunohistochemistry markers such as synaptophysin, chromogranin, EMA and Pan CK were used to come to a definitive diagnosis. Synaptophysin and chromogranin were found to be positive in the neuroendocrine component. EMA and Pan CK were found to be positive in the ductal component. Hence a diagnosis of mixed ductal neuroendocrine tumour (collision tumor) was made.

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Movila, Andrei, Viktoriya Didora, Dawid Zagacki, Marcin Braun, Alina Morawiec-Sztandera, and Dariusz Kaczmarczyk. "Malignant tumor of the peripheral nerve sheaths in the parotid gland - a case report." Polski Przegląd Otorynolaryngologiczny 8, no. 4 (December 18, 2019): 1–5. http://dx.doi.org/10.5604/01.3001.0013.6548.

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Abstract Neoplasms of the parotid glands constitute about 6% of head and neck tumours, the most common of which are: adenoma multiforme and Warthin’s tumor. Schwannoma is benign, encapsulated tumor of the nerve cells (lemocytes, Schwann cells), most often it occurs in the trunk, head, extremely rarely observed in the parotid gland. 9% Schwannomas derives from the facial nerve sheath, constituting from 0.5% -1.2% of all salivary gland tumors. The literature describes 80 cases of intraparotid Schwannoma. Malignant Schwannoma (MPNST) account for 5% to 10% of all soft tissue sarcomas. High-grade MPNST tumors are aggressive, with a tendency to relapse and metastasis. We present a case report of a 84-year-old female patient presented to the Head and Neck Oncology Clinic of the Medical University of Lodz, due to the painful tumor of the left parotid region. The tumor appeared six months before hospitalization. During the physical examination, there was a polycyclic tumor with reduced mobility, the skin on the tumor was slightly red, lymph nodes uninvolved, facial nerve function preserved. BACC revealed tumour tissue composed of sheets and spindle-shaped cells. The patient was qualified for surgical treatment. Under the general anesthesia the superficial lobe of the parotid gland along with the tumor was removed. After the procedure, no facial nerve palsy was found. The patient did well post-operatively and was discharged home on the 8th day after surgery. Immunohistochemical staining showed the tumour cells to be diffusely and strongly immunoreactive for S-100 protein and Ki67 40-50%. Strong and diffuse staining for S-100 protein were consistent with the malignant peripheral nerve sheath tumour (MPNST). The patient was referred for radiotherapy, due to the postoperative outcome and advanced age, no adjuvant treatment was proposed. The patient has been in observation for 1 year. No relapse was found in the follow-up studies.

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Schüler, Thomas, Sandra Körnig, and Thomas Blankenstein. "Tumor Rejection by Modulation of Tumor Stromal Fibroblasts." Journal of Experimental Medicine 198, no. 10 (November 17, 2003): 1487–93. http://dx.doi.org/10.1084/jem.20030849.

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Interleukin (IL)-4–secreting tumors are rejected in mice, an effect that is thought to be immune mediated. However, solid tumors are embedded in a stroma that often contains tumor-promoting fibroblasts, a cell population whose function is also affected by IL-4. Here we show that IL-4–secreting tumors grew undiminished in IL-4 receptor (R)–deficient (IL-4R−/−) mice. In IL-4R+/+ mice they were long-term suppressed in the absence of T cells but complete rejection required T cells, compatible with the assumption that hematopoietic cells needed to respond to IL-4. Surprisingly, bone marrow (BM) chimeric mice revealed that IL-4R expression exclusively on non-BM–derived cells was sufficient for tumor rejection. Fibroblasts in the tumor stroma were identified as a target cell type for IL-4 because they accumulated in IL-4–secreting tumors and displayed an activated phenotype. Additionally, coinjection of IL-4R+/+ but not IL-4R−/− fibroblasts was sufficient for the rejection of IL-4–secreting tumors in IL-4R−/− mice. Our data demonstrate a novel mechanism by which IL-4 contributes to tumor rejection and show that the targeted modulation of tumor-associated fibroblasts can be sufficient for tumor rejection.

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Schmid, Michael C., and Judith A. Varner. "Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation." Journal of Oncology 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/201026.

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Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy.

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Guimarães, Fernando, Alessandra Soares Schanoski, Tereza Cristina Samico Cavalcanti, Priscila Bianchi Juliano, Ana Neuza Viera-Matos, and Ovídio Rettori. "Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor." Brazilian Archives of Biology and Technology 53, no. 5 (October 2010): 1101–8. http://dx.doi.org/10.1590/s1516-89132010000500014.

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The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.

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Mott, Frank E., Alex Esana, Carl Chakmakjian, and Jon D. Herrington. "Tumor Lysis Syndrome in Solid Tumors." Supportive Cancer Therapy 2, no. 3 (April 2005): 188–91. http://dx.doi.org/10.3816/sct.2005.n.012.

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Rustin, Gordon J. S. "Circulating tumor markers in gynecological tumors." Current Opinion in Oncology 8, no. 5 (September 1996): 426–31. http://dx.doi.org/10.1097/00001622-199609000-00015.

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MÖBUS, VOLKER, SIGRID HORN, MICHAEL STÖCK, and VOLKER SCHIRRMACHER. "Tumor Cell Vaccination for Gynecological Tumors." Hybridoma 12, no. 5 (October 1993): 543–47. http://dx.doi.org/10.1089/hyb.1993.12.543.

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Massari, Francesco, Vincenzo Di Nunno, Francesca Comito, Marta Cubelli, Chiara Ciccarese, Roberto Iacovelli, Michelangelo Fiorentino, Rodolfo Montironi, and Andrea Ardizzoni. "Circulating tumor cells in genitourinary tumors." Therapeutic Advances in Urology 10, no. 2 (November 22, 2017): 65–77. http://dx.doi.org/10.1177/1756287217742564.

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Management of advanced urogenital malignancies has profoundly changed in recent years due to the development of novel targeted drugs that have significantly improved patient’s clinical outcomes. This process has been made possible mainly thanks to better knowledge of tumor genetic alterations and molecular altered pathways. Despite these remarkable results, several issues such as early detection of the disease as well as the research into early markers of recurrence or disease progression still remain an open challenge for clinical research. The detection of circulating tumor cells and circulating DNA appears an attractive option since it is a minimally invasive approach potentially able to allow clinicians an accurate diagnosis and maybe lead to more customized treatment strategies. This review focuses on the current techniques adopted for the detection and isolation of circulating tumor cells in genitourinary tumors highlighting their present and possible future application in clinical practice.

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Gemici, Cengiz. "Tumor Lysis Syndrome in Solid Tumors." Journal of Clinical Oncology 27, no. 16 (June 1, 2009): 2738–39. http://dx.doi.org/10.1200/jco.2009.22.4154.

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Gnoli, Maria, Francesca Ponti, and Luca Sangiorgi. "Tumor Syndromes That Include Bone Tumors." Surgical Pathology Clinics 10, no. 3 (September 2017): 749–64. http://dx.doi.org/10.1016/j.path.2017.04.009.

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Wolff, J. M., and F. K. Habib. "Tumor suppressor genes in urologic tumors." Urology 42, no. 4 (October 1993): 461–66. http://dx.doi.org/10.1016/0090-4295(93)90389-r.

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DeLeo, Albert B. "Tumor-Specific Antigens of Mouse Tumors." Journal of Immunotherapy 12, no. 3 (October 1992): 194–95. http://dx.doi.org/10.1097/00002371-199210000-00010.

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Kilgore, William B., and William M. Parrish. "Calcaneal Tumors and Tumor-like Conditions." Foot and Ankle Clinics 10, no. 3 (September 2005): 541–65. http://dx.doi.org/10.1016/j.fcl.2005.05.002.

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Alexander, Joseph M. "Tumor Suppressor Loss in Pituitary Tumors." Brain Pathology 11, no. 3 (April 5, 2006): 342–55. http://dx.doi.org/10.1111/j.1750-3639.2001.tb00404.x.

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KALLAS, ELIAS, RAFAEL DINIZ ABRANTES, and ALEXANDRE CIAPPINA HUEB. "Tumor lamination in mediastinal giant tumors." Revista do Colégio Brasileiro de Cirurgiões 44, no. 6 (December 2017): 655–58. http://dx.doi.org/10.1590/0100-69912017006007.

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ABSTRACT Mediastinum tumors may grow slowly and reach giant proportions without symptoms, hindering surgical removal. Tumor big dimensions difficult surgical maneuvers, with risk of uncontrollable bleeding and prejudice to surrounding structures. It may be necessary the use of exceptional measures such as venous-venous circulatory deviation, pre-operatory embolization and total extracorporeal circulation. We describe the technique of tumor lamination that allows for complete or almost complete resection of such tumors that in many occasions are not resectable. The description is based on the results of four patients treated with mediastinum giant tumors.

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Sarioglu, Sulen, Emel Kilicarslan, Barbaros Aydin, Melih Arif Kozen, Fadime Akman, Ilhan Oztop, Emel Ada, and Ahmet Omer Ikiz. "Tumor deposits in salivary gland tumors." Pathology International 68, no. 3 (February 21, 2018): 183–89. http://dx.doi.org/10.1111/pin.12637.

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Weintraub, Steven Jay. "Dormant Tumor-Suppressor Pathways in Tumors." American Journal of Respiratory Cell and Molecular Biology 20, no. 4 (April 1999): 541–42. http://dx.doi.org/10.1165/ajrcmb.20.4.f147.

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