Relevant bibliographies by topics / Tumor microenvironement

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'Tumor microenvironement'

Author: Grafiati
Published: 7 December 2024

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Journal articles on the topic "Tumor microenvironement"

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Evaristo, Cesar, Ramona Siemer, Elvira Criado-Moronati, et al. "Complete workflows allow comprehensive tumor microenvironment analysis and culture of cell subsets of limited tumor patient samples." Journal of Immunology 202, no. 1_Supplement (2019): 194.26. http://dx.doi.org/10.4049/jimmunol.202.supp.194.26.

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Abstract Immunotherapy has proven clinical efficacy and tremendous potential. But clinical benefit is experienced by only a subset of patients, such that additional research is necessary to improve outcomes. In particular, analyze steady-state anti-tumor immunity and monitor the effects of therapy on the tumor microenvironement. However, TIL numbers can be very low. Flow cytometry phenotyping different cell populations requires dividing limited tumor material into multiple samples, reducing the number of cells available for analysis. Therefore, innovative tools and workflows are needed to maxi
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Thomé, C., J. Blaes, P. Rübmann, et al. "P01.32 NDRG1 induced downregulation of CCL2 influences the migration of macrophages and impacts the tumor microenvironement." Neuro-Oncology 19, suppl_3 (2017): iii30. http://dx.doi.org/10.1093/neuonc/nox036.108.

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Rajappa, P., J. Krass, H. A. Riina, J. A. Boockvar, and J. P. Greenfield. "Super-Selective Basilar Artery Infusion of Bevacizumab and Cetuximab for Multiply Recurrent Pediatric Ependymoma." Interventional Neuroradiology 17, no. 4 (2011): 459–65. http://dx.doi.org/10.1177/159101991101700410.

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Ependymoma is a central nervous system tumor associated with a poor prognosis due to limited efficacy of current medical treatment modalities, often resulting in multiple surgical re-resections with each tumor recurrence. As traditional chemotherapeutic regimens have proved unsuccessful in long-term control of subtotally resected ependymoma, other agents targeting the tumor microenvironement including the angiogenic factors supplying neovascularization have recently been used. Anti-angiogenic agents such as bevacizumab are routinely used in adult patients with recurrent glioma. Selective intra
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Keane, Colm, Soi C. Law, Clare Gould, et al. "Elevated LAG-3 Expression in the Tumor Microenvironement of Patients with DLBCL Is Associated with a Non-GCB Phenotype and Poor Prognosis." Blood 132, Supplement 1 (2018): 1576. http://dx.doi.org/10.1182/blood-2018-99-112830.

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Abstract LAG3 is an immune checkpoint expressed on a variety of immune cells including a sub-population of 'exhausted' effector T cells and TREGs. Early-phase studies of anti-LAG3 mAb show promise in solid and haematological cancers. We have previously demonstrated LAG3 is enriched within the tumor microenvironment in Hodgkin Lymphoma (Gandhi et al. Blood 2006). Data in the aggressive B-cell lymphoma DLBCL is lacking. We used a conventional discovery/ validation approach in two population based Australian cohorts (discovery: Brisbane/Canberra; validation: Sydney) totalling 250 patients treated
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Le Tourneau, C., P. Cassier, F. Rolland, et al. "63MO TG4001 therapeutic vaccination combined with PD-L1 blocker avelumab remodels the tumor microenvironement (TME) and drives antitumor responses in human papillomavirus (HPV)+ malignancies." Annals of Oncology 31 (December 2020): S1442. http://dx.doi.org/10.1016/j.annonc.2020.10.551.

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Reading, N. Scott, Archana M. Agarwal, Ronald Hoffman, Josef T. Prchal, and Mohamed E. Salama. "Transcriptional Characterization of Myelofibrotic Bone Marrow Microenvironment Reveals Distinct Tumor Microenvironment in JAK2+ and Calr+ PMF Marrows." Blood 128, no. 22 (2016): 1954. http://dx.doi.org/10.1182/blood.v128.22.1954.1954.

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Abstract Background: Primary myelofibrosis (PMF) is a clonal stem cell disorder associated with somatic mutations in three genes: Janus kinase 2 (JAK2), calreticulin (CALR) and thrombopoietin receptor (MPL). Although, our understanding of the microenvironment in PMF is limited, in PMF levels of Treg, cytotoxic T-cells, B-cells, macrophages and megakaryocyte cell populations have been reported to be elevated in either peripheral blood or bone marrow (BM) (Barosi Curr Hematol Malig Rep 2014). In addition, various cellular pathways including JAK/STAT, TGFβ1, and cytokine pathways (CXC family, hem
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Aulakh, Sonikpreet, Joanne Xiu, Pavel Brodskiy, et al. "Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas (HGGs)." Journal of Clinical Oncology 40, no. 16_suppl (2022): 2019. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.2019.

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2019 Background: Gliomagenesis is regulated by dynamic epigenetic modifications of DNA methylation, deregulation of histones and alteration of the human Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes. These epigenetic genes are responsible for treatment resistance by inducing stemness of glioma cells and immune cells with in the tumor microenvironement (TME). We evaluated the key chromatin remodeling (CR) genes and their interactions with other regulatory genes that are of prognostic importance. Methods: 1856 HGGs underwent molecular profiling at Caris Life Sciences (P
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Gerby, Bastien, Diogo F. T. Veiga, Jana Krosl, et al. "Targeting Pre-Leukemic Stem Cells in T-Acute Lymphoblastic Leukemia." Blood 128, no. 22 (2016): 527. http://dx.doi.org/10.1182/blood.v128.22.527.527.

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Abstract Current chemotherapy of pediatric T cell acute lymphoblastic leukemia (T-ALL) efficiently reduces the tumor mass with, however, undesirable long term consequences and remains ineffective in adolescent and adult T-ALL. Furthermore, relapse can be caused by pre-leukemic stem cells (pre-LSCs) that were spared by current protocols and evolved to malignancy. A distinctive characteristic of pre-LSCs is their critical dependence on interactions with the microenvironment for survival, which guided our strategy to target pre-LSCs using niche-based screening assays. Using transgenic mouse model
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de Fontbrune, FS, Danielle Canioni, Hugo Chapdelaine, et al. "High Level of CD71 Expression On Neoplastic B Cells At Diagnosis Is Predictive of Overall Survival After Rituximab and Anthracyclines Based Regimen in Follicular Lymphoma." Blood 120, no. 21 (2012): 1601. http://dx.doi.org/10.1182/blood.v120.21.1601.1601.

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Abstract Abstract 1601 Background: The prognosis of follicular lymphoma (FL) remains a challenge despite stratification on the FLIPI scoring, histological grading, and microenvironement cell type infiltration. Thus, new biomarkers are needed to identify patients (pts) who require a more aggressive therapeutic strategy or targeted therapies. Transferrin receptor (TfR) is highly expressed in proliferating cells including non Hodgkin lymphoma cells. High TfR level has been associated with disease progression in chronic lymphocytic leukaemia and is observed at relapse in mantle cell lymphoma. Muri
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Reading, N. Scott, Josef T. Prchal, Ronald Hoffman, and Mohamed E. Salama. "Digital Immune Expression Profiling Coupled with Immunohistochemistry for Interrogation of Microenvironment in Formalin Fixed Paraffin Embedded Specimens of Marrow and Spleen from PMF Patients." Blood 126, no. 23 (2015): 2832. http://dx.doi.org/10.1182/blood.v126.23.2832.2832.

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Abstract Background: Gene expression profiling studies have demonstrated aberrant expression of inflammatory response genes in myeloproliferative neoplasm (MPN) granulocytes and/or CD34+ cells. Our understanding of the immune response to primary myelofibrosis (PMF) hematopoietic stem cells and tissue-specific microenvironments is not complete due to a limited availability of bone marrow (BM) aspirates and fresh spleen samples from PMF patients. In order to overcome this obstacle, we utilized a novel approach with mRNA enrichment analysis which utilizes formalin fixed, paraffin embedded (FFPE)
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Dissertations / Theses on the topic "Tumor microenvironement"

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Krejbich, Morgane. "Modulation du compartiment vasculaire par les cellules tumorales de cancers pulmonaires et son impact sur le micro-environnement immunitaire." Electronic Thesis or Diss., Nantes Université, 2024. http://www.theses.fr/2024NANU1013.

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Les cancers du poumon sont responsables de plus de 1,8 million de décès dans le monde chaque année, dont le cancer bronchique non à petites cellules (CBNPC) représentant 85% des cas. Aujourd'hui, l'immunothérapie est le traitement majeur du CBNPC et vise à inverser l'anergie des LTs intra-tumoraux et restaurer leur action antitumorale. Malgré leur efficacité, seulement 15 à 20% des patients sont répondeurs et de fait, une meilleure compréhension du micro- environnement tumoral (TME) est requise. Le compartiment vasculaire est une composante majeure du TME et favorise la croissance tumorale par
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Berchem, Guy. "Rôle du stress hypoxique dans la régulation de la réponse immunitaire anti-tumorale des lymphocytes "Natural Killer"." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T105/document.

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Le microenvironnement tumoral, et notamment le stress hypoxique, joue un rôle immunosuppressif permettant l’échappement des cellules tumorales à la surveillance du système immunitaire. Des études récentes ont montré que l’échange de microvésicules (MVs) entre les cellules tumorales et les cellules du système immunitaire peut être responsable de l’établissement d’un microenvironnement immunosuppressif. Dans ce contexte, nous avons étudié l’effet des MVs issues des cellules tumorales hypoxiques sur la cytotoxicité des cellules «Natural Killer» (NKs). Nos résultats démontrent clairement que les c
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Chabab, Ghita. "Caractérisation d'une sous-population de LT γδ régulateurs dans les cancers solides humains". Electronic Thesis or Diss., Université de Montpellier (2022-....), 2022. http://www.theses.fr/2022UMONT067.

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Les LT γδ contribuent à l'immunité anti-tumorale au sein du microenvironnement tumoral dans divers cancers. Malgré leurs fonctions effectrices bien décrites, de récentes études ont corrélé leur présence dans le microenvironnement tumoral à une meilleure progression des tumeurs solides, suggérant que les LT γδ peuvent présenter des activités pro-tumorales. Mon projet visait à caractériser ces LT γδ présentant des activités tumorales et à déchiffrer leur rôle dans le cancer. Nous avons démontré in vitro que les signaux inflammatoires favorisent le développement d'une sous-population de LT γδ rég
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Agarwal, Pranay. "Multiscale Biomaterials for Cell and Tissue Engineering." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1482945107612275.

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Conference papers on the topic "Tumor microenvironement"

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Pominova, D. V., A. V. Ryabova, A. S. Skobeltsin, I. V. Markova, and I. D. Romanishkin. "The Combined Use of Methylene blue and Chlorin E6 Photosensitizers for Photodynamic Therapy and Correction of the Tumor Microenvironement." In 2024 International Conference Laser Optics (ICLO). IEEE, 2024. http://dx.doi.org/10.1109/iclo59702.2024.10624192.

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Meyer, Moritz, Christoph Arolt, Alexander Quaas, et al. "Analysis of the expression of LAG3 in the tumor microenvironement of aggressive salivary gland carcinomas." In 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1767269.

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