Academic literature on the topic 'Tuberculose – Imagerie'
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Journal articles on the topic "Tuberculose – Imagerie":
Thumerelle, C., G. Pouessel, S. Errera, D. Penel-Capelle, S. Morillon, C. Santos, Y. Robert, and A. Deschildre. "Imagerie de la tuberculose pulmonaire." Archives de Pédiatrie 12 (August 2005): S132—S136. http://dx.doi.org/10.1016/s0929-693x(05)80029-6.
Bouaziz, M. Chelli, M. F. Ladeb, M. Chakroun, and S. Chaabane. "Imagerie de la tuberculose rachidienne." EMC - Radiologie et imagerie médicale - Musculosquelettique - Neurologique - Maxillofaciale 4, no. 1 (January 2009): 1–12. http://dx.doi.org/10.1016/s1879-8551(09)70818-8.
Khalil, A., and G. Léveiller. "Imagerie de la tuberculose extrapulmonaire." Revue des Maladies Respiratoires 25, no. 6 (May 2008): 57–59. http://dx.doi.org/10.1016/s0761-8425(08)56021-9.
Fockyee, C., C. Beigelman, S. Daou, M. Soussan, M. Brauner, D. Bouvry, and P. Y. Brillet. "Imagerie de la tuberculose pulmonaire." Feuillets de Radiologie 55, no. 4 (September 2015): 206–30. http://dx.doi.org/10.1016/j.frad.2015.06.004.
Thabet, I., K. Mrad Dali, W. Gamaoun, N. Haddad, W. Gamaoun, N. Arifa, A. F. Mosbah, and K. Tlili Graiess. "AGU9 Imagerie de la tuberculose urinaire." Journal de Radiologie 86, no. 10 (October 2005): 1462–63. http://dx.doi.org/10.1016/s0221-0363(05)75896-0.
Lezar, S., M. Mastour, and R. Kadiri. "DIG62 Imagerie de la tuberculose abdominale." Journal de Radiologie 87, no. 10 (October 2006): 1470–71. http://dx.doi.org/10.1016/s0221-0363(06)87638-9.
Allali, N., and R. Dafiri. "Imagerie de la tuberculose thoracique chez l’enfant." Journal de Radiologie 86, no. 10 (October 2005): 1386. http://dx.doi.org/10.1016/s0221-0363(05)75647-x.
Taleb, F., and R. Dafiri. "RP29 Imagerie de la tuberculose abdominale de l’enfant." Journal de Radiologie 85, no. 9 (September 2004): 1564. http://dx.doi.org/10.1016/s0221-0363(04)77892-0.
Bouden, A., M. Abdelkefi, H. Annabi, M. Mbarek, and M. Jamoussi. "OA-WS-50 Imagerie de la tuberculose osteo-articulaire." Journal de Radiologie 88, no. 10 (October 2007): 1580–81. http://dx.doi.org/10.1016/s0221-0363(07)81915-9.
Ky, S., H. Lam, S. Yay, D. Jeanbourquin, and B. Richner. "Imagerie de la tuberculose hepatique de l’enfant au cambodge." Journal de Radiologie 86, no. 10 (October 2005): 1446. http://dx.doi.org/10.1016/s0221-0363(05)75848-0.
Dissertations / Theses on the topic "Tuberculose – Imagerie":
Durant-Robin, Geneviève. "Tuberculose pseudo-métastatique du foie : étude générale et imagerie, à propos d'un cas." Montpellier 1, 1988. http://www.theses.fr/1988MON11238.
Tuck, Michael. "Molecular characterization of tuberculosis by MALDI mass spectrometry - applications toward multi-omic and multimodal imaging." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0015.
This thesis aims to address the urgent health challenge of tuberculosis (TB) through the development of a robust and efficient quantitative mass spectrometry imaging (QMSI) strategy, specifically focusing on the anti-TB drugs - clofazimine (CFZ), rifampicin (RIF), and ethambutol (ETM). TB, caused by Mycobacterium tuberculosis (Mtb), poses a global health threat, also reinforced by bacterial resistance, leading to the implementation of lines of therapy based on the use of an adapted treatment with a panel of proven antibiotics for more effective treatment. For these reasons, a more comprehensive understanding of spatially-aware drug quantification and characterization of the surrounding molecular microenvironment is required.The investigation adopts the tissue mimetic model for the development of a QMSI approach for the quantification of multiple antibiotics from a single tissue section, striking a balance between accurate drug quantification, preservation of the tissue microenvironment, as well as compatibility with multimodal imaging. Challenges associated with the diverse panel of TB drugs, each with unique analytical requirements, are navigated. The choice of drugs prioritizes CFZ, RIF, and ETM for their detectability and clinical relevance.The first aim details the adoption of QMSI through the mimetic tissue model, calibration curve establishment, and the rationale behind drug choices. Results and discussion cover the evaluation of drug detectability in lung tissue from mice infected with tuberculosis and then treated with a panel of antibiotics, and discusses the determination of sensitivity and detection limits, and the intricacies of the QMSI approach. Challenges specific to CFZ, such as solubility, are addressed. The study culminates in the quantification of CFZ by MALDI-MSI for the first time to our knowledge.Building on this groundwork, a novel MALDI QMSI workflow is developed for the simultaneous quantification and localization of CFZ, RIF, and ETM in TB-infected mouse lung tissue. The study surpasses the gold standard of laser capture microdissection combined with liquid chromatography MS regarding spatial resolution.Positive ionization mode analysis reveals CFZ accumulating in the cellular rim and within foamy macrophages, while ETM primarily localizes in the vasculature. RIF, which was analyzed in negative ionization mode, exhibits a more uniform distribution across tissue regions. By analyzing in both positive and negative ionization modes, a comprehensive dataset detecting bacterial lipid species associated with Mtb from a single tissue section is obtained.We leverage the hyperspectral nature of MALDI-MSI as the basis for analyses in order to quantify drugs in tissue, our main objective; however, our QMSI decisions were informed to facilitate future multi-omic and multimodal analyses. Such multi-omic analyses were explored by MALDI-MSI, as well as the feasibility of implementing other modalities such as Raman spectroscopy and MALDI-Immunohistochemistry (MALDI-IHC).The approaches of this thesis advance our understanding of drug levels in TB-infected tissue and showcase the versatility of MALDI QMSI for broader applications. The study's outcomes offer a powerful tool for evaluating drug efficacy in complex microenvironments, providing valuable insights into the molecular characterization and multi-targeted quantification of anti-TB drugs
Asmar, Shady. "Diagnostic rapide de la tuberculose par culture." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5024.
Isolation of Mycobacterium tuberculosis by culture is the gold standard for the diagnosis of tuberculosis. The aim of my thesis work was to simplify and improve the culture diagnosis of tuberculosis. At first we started with a bibliographic study, comparing step by step the different techniques and protocols that have been used for the diagnosis of tuberculosis. This work has allowed us to update our tuberculosis diagnosis protocol, starting with the implementation of a "Tuberculosis-kit" consisting of chlorhexidine containing containers for the recovery and decontamination of non-invasive specimens, followed by culture on an egg-based medium, a micro- colonies detection using an inverted microscope or an automated real-time imaging incubator system and finally an identification using mass spectrometry. We established a new chlorhexidine- based decontamination method that we showed to be more efficient for the recovery and isolation of M. tuberculosis than the standard NALC-NaOH method. Than we developed a new serum-based culture medium, the MOD9 that we showed in a comparative study to be superior to the reference LJ medium for the recovery of M. tuberculosis. In a second study we proved that our chlorhexidine/MOD9 protocol was superior to the standard NALC-NaOH/Bactec 960 MGIT protocol for the isolation of M. tuberculosis. And finally the implementation of a real time imaging system for the detection of M. tuberculosis micro-colonies on MOD9 permits us to dramatically reduce the detection time from 15 days with the standard NALC-NaOH/Bactec 960 MGIT protocol to 3.2 days with our 0.7%-chlorhexidine/MOD9/Advencis-Biosystem protocol with a world record detection time of 25h
Midroit, Maellie. "Signatures neurales de la perception hédonique des odeurs chez la souris." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1005/document.
In humans and animals, odors guide behavior and motivate action. The hedonic value (that is the pleasantness) is the main olfactory dimension and is generally used to decide to approach the odor source or move away. While this attractiveness is shaped by experience, some unfamiliar odors are spontaneously attractive or repulsive. The pleasantness of an odor would be, at least in part, innate, and suggest a specific neural signature of the hedonic value of odors. The global aim of this thesis is to decipher neuronal mechanisms underlying the hedonic value of odors.After having selected odorants with various level of attraction (pleasant and unpleasant), we have deciphered the neural bases that underlie these behaviors.We first mapped (expression of Zif268) and then manipulated (optogenetic) the neuronal activity of the olfactory bulb in response to these odors, and have revealed a bulbar neural signature of the hedonic value of odors along the antero-posterior axis.Then, in order to analyze how the hedonic information was interpreted by the higher olfactory and associative areas, we developed a method allowing the registration of brain activity in a reference atlas, that ensure a fast, accurate and reliable mapping of this activity. Finally, by combining this method with behavioral, electrophysiological and pharmacological approaches, we have shown a role of the reward system in the coding of odor hedonics and that an odor can act as a reward, thus motivating behavior, approach and withdrawal
Rolla, Paula Mota Theo. "Behavioral and neurobiological studies of visual processing in honeybees." Toulouse 3, 2011. http://www.theses.fr/2011TOU30111.
Vision in honeybees has been extensively studied at the behavioral level by training free-flying insects to choose visual targets rewarded with sucrose solution, and, to a lesser degree, at the physiological level using intracellular electrophysiological recordings of single neurons in different areas of the visual circuits of the bee brain. However, our knowledge of visual processing in honeybees is still limited by the lack of: 1- conditioning protocols for studying visual learning and memory in harnessed animals under controlled laboratory conditions; 2- anatomical and physiological characterizations of visual neuropils in the central brain; and 3- techniques for performing functional studies of visual processing at the neuronal circuit level. In the present work, we aimed at filling these gaps by providing a multilevel study of visual processing in harnessed bees. We aimed at developing novel appetitive and aversive conditioning protocols for studying visual learning and memory in harnessed bees. In an appetitive framework, we showed that intact harnessed bees are not capable of learning a direct association between color and sucrose. For reasons so far unknown, antennae ablation is necessary for harnessed bees to acquire such an elemental color-sucrose association. Despite this incapacity, intact bees are able to solve a non-elemental bimodal discrimination in which colors act as modulators of appetitive olfactory learning. We therefore provide the first controlled demonstration of bimodal (color-odor) occasion setting in harnessed honeybees. In an aversive framework, we established a new conditioning protocol in which harnessed bees learn aversive associations between visual cues and an electric shock. We showed that bees with intact antennae learn to discriminate punished from non-punished visual stimuli by relying on their chromatic or achromatic cues, or both. Antennae ablation was not only unnecessary for learning to occur but it even impaired visual conditioning due to a concomitant reduction of responsiveness to the electric shock. Both behavioral protocols, appetitive and aversive, open new doors for accessing the neural correlates of visual and/or bimodal learning and memory in honeybees. We also provided a comprehensive neuroanatomical description of unstudied visual circuits in the central bee brain. More specifically, we characterized the organization and neural architecture of the anterior optic tubercle (AOTu) and revealed a segregation of dorso-ventral visual information into this structure. Having established a novel protocol for performing optophysiological recordings of visual-circuit activity in the honeybee brain, we studied the responses of AOTu interneurons during visual stimulation of the compound eye. We showed that light stimuli presented in different parts of the visual field induced distinct patterns of activation in these interneurons, consistent with the dorso-ventral segregation revealed by our neuroanatomical data. Stimulation of AOTu interneurons with monochromatic lights and with chromatic mixtures induced distinct signal intensities, time-course dynamics and activity patterns, thus revealing intricate chromatic processing properties in this visual neuropil. Our studies provide therefore an innovative, multilevel analysis of visual processing in honeybees, spanning from behavioral studies on elemental and non-elemental visual learning to neurobiological studies on visual processing and coding in the honeybee central brain. Taken together our studies open new doors to investigate for the first time experience-dependent changes of neural activity in the bee brain related to visual and/or bimodal learning, a goal that has remained elusive until now
Atallah, Elias. "Transmission des voies olfactives aux cellules réticulospinales de la lamproie." Thèse, 2011. http://hdl.handle.net/1866/7056.
Olfactory inputs are known for their ability to induce specific motor behaviors. Despite numerous behavioral observations in vertebrates, the mechanisms and the neural pathways underlying the olfactory-locomotor transformation are still unknown. In lamprey, recent studies have described this pathway and the mechanism underlying the transformation of olfactory input into a locomotor activity (Derjean et al., 2010). This pathway originates in the medial part of the olfactory bulb, sends projections to the posterior tuberculum, a diencephalic region. From there, the neurons project directly to the mesencephalic locomotor region that is known to send projections to the reticulospinal neurons to activate locomotion. Using lamprey brain preparation, electrophysiology and calcium imaging, the aim of this study was to establish whether all reticulospinal neurons respond to olfactory stimuli. Electrical stimulation of the olfactory nerves, the medial part of the olfactory bulb or the posterior tuberculum activates all reticulospinal cells in the four reticular nuclei (ARRN: Anterior rhombencephalic reticular nucleus; MRN: middle mesencephalic reticular nucleus; MRRN: middle rhombencephalic reticular nucleus; PRRN: posterior rhombencephalic reticular nucleus). The medial part of the olfactory bulb is the only region that is implicated in transmitting the olfactory information to reticulospinal neurons. We also discovered that when blocking the GABAergic receptors in the medial part of the olfactory bulb, the reticulospinal neurons have a stronger response to olfactory stimulation. Thus we showed that a tonic inhibition is involved in the modulating depression of the olfacto-locomotor pathway. Altogether, this work shows that stimulation of the olfactory sensory inputs activates simultaneously the entire population of reticulospinal neurons that control locomotion. In addition, there is a GABAergic tonic inhibition at the level of the medial part of the olfactory bulb that causes a modulating depression in the olfacto-locomotor pathway.
Book chapters on the topic "Tuberculose – Imagerie":
Monge, Luigi. "Infestations, Pandemics, Epidemics, and Diseases." In Wasn't That a Mighty Day, 255–360. University Press of Mississippi, 2022. http://dx.doi.org/10.14325/mississippi/9781496841698.003.0004.