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Academic literature on the topic 'TTrx'

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Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "TTrx"

1

Prapunpoj, Porntip, Samantha J. Richardson, and Gerhard Schreiber. "Crocodile transthyretin: structure, function, and evolution." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283, no. 4 (October 1, 2002): R885—R896. http://dx.doi.org/10.1152/ajpregu.00042.2002.

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Structure and function were studied for Crocodylus porosustransthyretin (crocTTR), an important intermediate in TTR evolution. The cDNA for crocTTR mRNA was cloned and sequenced and the amino acid sequence of crocTTR was deduced. In contrast to mammalian TTRs, but similar to avian and lizard TTRs, the subunit of crocTTR had a long and hydrophobic NH2-terminal region. Different from the situation in mammals, triiodothyronine (T3) was bound by crocTTR with higher affinity than thyroxine (T4). Recombinant crocTTR and a chimeric construct, with the NH2-terminal region of crocTTR being replaced by that of Xenopus laevis TTR, were synthesized in the yeast Pichia pastoris. Analysis of the affinity of the chimeric TTRs showed that the NH2-terminal region modulates T4 and T3 binding characteristics of TTR. The structural differences of the NH2-terminal regions of reptilian and amphibian TTRs were caused by a shift in splice sites at the 5′ end of exon 2. The comparison of crocodile and other vertebrate TTRs shows that TTR evolution is an example for positive Darwinian evolution and identifies its molecular mechanism.
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Chen, Meijuan, Zhousheng Lin, Guangyu Yao, Xi Hong, Xiaolei Xue, and Lujia Chen. "A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A." Bioinorganic Chemistry and Applications 2021 (December 30, 2021): 1–7. http://dx.doi.org/10.1155/2021/2495958.

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TTRE, a photosensitizer molecule, has excellent biofluorescence imaging performance and effective antitumor properties for breast cancer. However, its application in breast cancer treatment is limited due to poor tumor selectivity and lack of targeting ability. In this study, TTRE and trastuzumab were combined to synthesize Tra-TTR-A, a novel near-infrared fluorescent nanoprobe for HER2 positive breast cancer. The targeting and antitumor abilities of Tra-TTR-A in breast cancer were also investigated. Like TTRE, Tra-TTR-A has a stable structure with remarkable optical properties and in vivo imaging capacity. However, Tra-TTR-A not only inhibits tumor growth by generating reactive oxygen species but also kills tumor cells by trastuzumab. In this study, Tra-TTR-A, a new type of near-infrared fluorescent nanoprobe that targets HER2-positive breast cancer, was successfully synthesized. Tra-TTR-A could be used in in vivo imaging, targeted photodynamic therapy, and diagnosis and treatment for breast cancer.
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Sorokin N. I. "Effect of iso- and heterovalent cation substitutions on the superionic Faraday transition in fluorite-type modification β-PbF-=SUB=-2-=/SUB=-." Physics of the Solid State 64, no. 7 (2022): 841. http://dx.doi.org/10.21883/pss.2022.07.54591.328.

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The influence of isovalent substitutions of Pb2+-> Cd2+ and heterovalent substitutions of Pb2+-> Sc3+ on a superionic Faraday transition in Pb1-xCdxF2 (x=0.33) and Pb1-xScxF2+x (x=0.1) solid solutions based on the fluorite-type modification β-PbF2 with sp. gr. Fm 3 m has been studied. The Faraday phase transition can be characterized by the temperature Ttrλ corresponding to maximum on the heat capacity curve and temperature Ttrα corresponding to the beginning of the structural disorder anion sublattice. Both of these temperatures are found on the temperature conductivity dependence sigmadc(T) of β-PbF2, Pb0.67Cd0.33F2 and Pb0.9Sc0.1F2.1 crystals. The values of Ttrλ and Ttrα in solid solutions compared with β-PbF2 (Ttrλ=715±10 K, Ttrα = 597±12 K) decrease by 100-110 and 30-45 K for Pb0.67Cd0.33F2 and Pb0.9Sc0.1F2.1, respectively. Decreasing of temperature Ttrλ leads to an increase in temperature interval of existence of the superionic state. For T>Ttrλ the anionic conductivity of fluorite-type Pb0.67Cd0.33F2, Pb0.9Sc0.1F2.1, and β-PbF2 crystals reaches anomalously high values of sigmadc = 1-2 S/cm (873 K) at an ion transfer activation enthalpy equals to Hsigma~0.3 eV. Keywords: phase transitions, fluorides, fluorite structure, ionic conductivity, solid solutions.
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Matsushita, Hiroaki, Yohei Misumi, Teruaki Masuda, Masamitsu Okada, Fumika Inoue, Mitsuharu Ueda, and Yukio Ando. "Urinary Transthyretin as a Biomarker in ATTRv Val50Met Amyloidosis." Pathophysiology 29, no. 3 (June 29, 2022): 333–43. http://dx.doi.org/10.3390/pathophysiology29030025.

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Transthyretin (TTR), the precursor protein for amyloidogenic TTR (ATTR) amyloidosis, forms tetramers and escapes glomerular filtration by binding with thyroxine and retinol-binding protein. However, variant TTRs are unstable as tetramers, so monomeric TTR has become the precursor protein of amyloid deposits, via protein misfolding. The aim of the study was to evaluate the utility of urinary TTR in the diagnosis of ATTRv amyloidosis. Urinary samples from healthy volunteers, ATTRv V50M amyloidosis patients, and asymptomatic carriers of the ATTRv V50M gene were analysed using ELISA. To analyse the different forms of TTR secreted to the urine, we performed Western blotting and mass spectrometry. Urinary TTR concentrations were significantly higher in the ATTRv V50M amyloidosis patients than they were in the healthy volunteers and asymptomatic carriers of the gene. Although the TTR concentrations were negligible in the healthy volunteers, they were correlated with disease progression and urinary albumin concentrations in the ATTRv V50M amyloidosis patients. The Western blotting and mass spectrometry revealed the presence of monomeric wild-type and variant TTRs in the urine. Urinary TTR concentrations may become a more sensitive biomarker of ATTRv progression than albumin.
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Ju, Ze-Min, Hai-Lang Jia, Xue-Hai Ju, Xing-Fu Zhou, Zhi-Qiang Shi, He-Gen Zheng, and Ming-Dao Zhang. "Improvement of dye-sensitized solar cells performance through introducing different heterocyclic groups to triarylamine dyes." RSC Advances 5, no. 5 (2015): 3720–27. http://dx.doi.org/10.1039/c4ra13782e.

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The overall power conversion efficiency (PCE) of DSSCs based on TTR1–3 with chenodeoxycholic acid (CDCA) coadsorbant are 5.20%, 5.71% and 6.30%, respectively, and the value of TTR3 is close to that of N719 (6.62%).
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Hess, Carla W., Holly T. Haug, and Richard G. Landry. "The Reliability of Type-Token Ratios for the Oral Language of School Age Children." Journal of Speech, Language, and Hearing Research 32, no. 3 (September 1989): 536–40. http://dx.doi.org/10.1044/jshr.3203.536.

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This study investigated the alternate forms reliability of four type-token ratios (TTRs) of oral language samples obtained from 52 elementary school children (9 through 12 years of age). The four TTRs included the basic type-token ratio, the corrected type-token ratio, the root type-token ratio, and the bilogarithmic type-token ratio. Language samples of 600 words were segmented into 50-word, 100-word, and 200-word samples. Within each TTR measure, there were no significant differences among the means for samples of the same size, but all means for a given sample size differed significantly from the means of all other sample sizes. Further, for samples of the same size the reliability coefficients calculated for each TTR measure were neither consistent nor significant. These findings indicate that under the conditions of the present study TTRs are not comparable when calculated for different sample sizes ranging from 50 to 600 words, and further, that they are not reliable measures of the language performance of individual elementary school children from regular classrooms for language samples of 50 to 200 words.
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Chen, Zhen, and Wei Fan. "Data analytics approach for travel time reliability pattern analysis and prediction." Journal of Modern Transportation 27, no. 4 (September 12, 2019): 250–65. http://dx.doi.org/10.1007/s40534-019-00195-6.

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Abstract Travel time reliability (TTR) is an important measure which has been widely used to represent the traffic conditions on freeways. The objective of this study is to develop a systematic approach to analyzing TTR on roadway segments along a corridor. A case study is conducted to illustrate the TTR patterns using vehicle probe data collected on a freeway corridor in Charlotte, North Carolina. A number of influential factors are considered when analyzing TTR, which include, but are not limited to, time of day, day of week, year, and segment location. A time series model is developed and used to predict the TTR. Numerical results clearly indicate the uniqueness of TTR patterns under each case and under different days of week and weather conditions. The research results can provide insightful and objective information on the traffic conditions along freeway segments, and the developed data-driven models can be used to objectively predict the future TTRs, and thus to help transportation planners make informed decisions.
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Augustaitis, Aistis, and Vytautas Jurėnas. "Dynamics of trunk type robot with spherical piezoelectric actuators." IAES International Journal of Robotics and Automation (IJRA) 9, no. 2 (June 1, 2020): 113. http://dx.doi.org/10.11591/ijra.v9i2.pp113-122.

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<p class="Abstract">Trunk type robots (TTRs) are exclusive. These robots can provide a high level of maneuverability and have a potential in medicine or high risk zones. TTRs are determined as a long serial linkage of similar segments. They are usually connected using tendons or small actuators. A spherical actuator is the most appreciable option. The motion of real spherical actuator (RSA) can be easily obtained applying an inverse piezoelectric effect. It has three independent spinning axes. These axes are perpendicular to each other despite the history of excitation. Kinematics and dynamics of RSA almost have no basics regardless of mentioned features. This situation can be explained according to common disadvantages of other SAs: sophisticated structure and complex control. The structures and abilities of TTRs are reviewed in the first section of this article. At the beginning of the fourth section the kinematics of piezoelectric TTR with two different RSAs is introduced. Its results of inverse dynamics using Euler-Lagrange equations are presented at the end of the fourth section. Similar results are derived using an analytical-potential method in the fifth section. It is quite accurate and effective option to determine inverse dynamics of the TTR employing an analytical-potential method.</p>
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Benson, Merrill D., Elizabeth J. Ackermann, and Brett P. Monia. "Treatment of transthyretin cardiomyopathy with a TTR-specific antisense oligonucleotide (IONIS-TTRRx)." Amyloid 24, sup1 (March 16, 2017): 134–35. http://dx.doi.org/10.1080/13506129.2017.1280015.

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Guan, Zeqiang, Christina M. Hughes, Settapong Kosiyatrakul, Paolo Norio, Ranjan Sen, Steven Fiering, C. David Allis, Eric E. Bouhassira, and Carl L. Schildkraut. "Decreased replication origin activity in temporal transition regions." Journal of Cell Biology 187, no. 5 (November 30, 2009): 623–35. http://dx.doi.org/10.1083/jcb.200905144.

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In the mammalian genome, early- and late-replicating domains are often separated by temporal transition regions (TTRs) with novel properties and unknown functions. We identified a TTR in the mouse immunoglobulin heavy chain (Igh) locus, which contains replication origins that are silent in embryonic stem cells but activated during B cell development. To investigate which factors contribute to origin activation during B cell development, we systematically modified the genetic and epigenetic status of the endogenous Igh TTR and used a single-molecule approach to analyze DNA replication. Introduction of a transcription unit into the Igh TTR, activation of gene transcription, and enhancement of local histone modifications characteristic of active chromatin did not lead to origin activation. Moreover, very few replication initiation events were observed when two ectopic replication origin sequences were inserted into the TTR. These findings indicate that the Igh TTR represents a repressive compartment that inhibits replication initiation, thus maintaining the boundaries between early and late replication domains.
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Dissertations / Theses on the topic "TTrx"

1

Gregory, Mary Sarah-Jane, and n/a. "Thioredoxin and Oxidative Stress." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040301.082639.

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The experiments described in this thesis involve the expression and characterisation of recombinant truncated thioredoxin (tTrx) and the potential involvement that thioredoxin (Trx) has in the cellular responses to oxidative stress. Truncated Trx (80 amino acids) was expressed from a plasmid containing the ORF for tTrx that had been introduced into E.coli BL-21(DE3) cells. The protein was initially extracted using a combination of high concentrations of urea, high pH levels, and multiple sonification steps to remove the tTrx from inclusion bodies formed during expression. This procedure produced a stable solution of tTrx. Purification of tTrx from this protein solution required anion exchange chromatography followed by gel permeation in a HPLC system to obtain fully purified, recombinant tTrx which allowed further characterisation studies to be undertaken. An initial investigation into tTrx was performed to determine some basic physical, biochemical and functional aspects of this hitherto relatively undefined protein. Analysis by sedimentation equilibrium indicated that freshly prepared tTrx forms a single species with a molecular weight of 18.8kDa. This value indicates that recombinant tTrx naturally forms a dimer in solution that was shown to be non-covalent in nature and stable in solution. The capacity of tTrx to reduce protein disulphide bonds was determined using the insulin reduction assay. Results show that tTrx lacks this particular redox ability. The rate of oxidisation at 4 degrees C was analysed using free thiol determination, sedimentation equilibrium and SDS-PAGE patterning. Results indicated a steady rise in the degree of oxidation of tTrx over an eight day period. After six days the oxidated protein consistently displayed the presence of intramolecular disulphide bonds. Covalently-linked disulphide dimers and higher molecular weight oligomers were detectable after eight days oxidation. An investigation of the reducing capacity of the basic Trx system determined that fully oxidised tTrx was unable to act alone as a substrate for thioredoxin reductase (TR). However, when reduced Trx was added to the system, it appeared capable of acting as an electron donor to the oxidised tTrx in order to reduce disulphide groups. Recombinant tTrx was successfully radiolabelled with Trans 35S-methionine/cysteine for use in cell association studies. No evidence was found to indicate the presence of a receptor for tTrx on either MCF-7 or U-937 cells. Findings suggest that a low level of non-specific binding of tTrx to these cell lines rather than a classical ligand-binding mechanism occurs thus suggesting the absence of a cell surface receptor for tTrx. The role that Trx may play in the cellular responses to oxidative stress was also investigated. The chemical oxidants hydrogen peroxide (H2O2) and diamide were used to establish an in vitro model of oxidative stress for the choriocarcinoma cytotrophoblast cell line JEG-3. Cellular function was assessed in terms of membrane integrity, metabolic activity and the ability to synthesis new DNA following exposure to these oxidants. Results indicated that both agents were capable of causing cells to undergo oxidative stress without inducing immediate apoptosis or necrosis. Initially, JEG-3 cells exposed to 38μM or 75μM H2O2 or 100μM diamide were shown to display altered cell metabolism and DNA synthesis without loss to cell viability or membrane integrity. Cells were also shown to be capable of some short-term recovery but later lapsed into a more stressed state. Expression levels of Trx were studied to determine whether this type of chemical stress caused a change in intercellular protein levels. Both cELISA and western blotting results indicated that only cells exposed to 100μM diamide displayed any significant increase in Trx protein levels after 6 or 8hrs exposure to the oxidant. Further studies over a longer time-frame were also performed. These found that when JEG-3 cells were exposed to 18μM H2O2 or 200μM diamide over 12-48hrs, a positive correlation between increasing endogenous Trx protein levels and a decline in cell proliferation was observed. Cytotrophoblast cells, which are responsible for implantation and placentation, are susceptible to oxidative stress in vivo and their anti-oxidant capacity is fundamental to the establishment of pregnancy. The findings obtained during these studies suggest that Trx plays a role in this process.
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2

Gregory, Mary Sarah-Jane. "Thioredoxin and Oxidative Stress." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367183.

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The experiments described in this thesis involve the expression and characterisation of recombinant truncated thioredoxin (tTrx) and the potential involvement that thioredoxin (Trx) has in the cellular responses to oxidative stress. Truncated Trx (80 amino acids) was expressed from a plasmid containing the ORF for tTrx that had been introduced into E.coli BL-21(DE3) cells. The protein was initially extracted using a combination of high concentrations of urea, high pH levels, and multiple sonification steps to remove the tTrx from inclusion bodies formed during expression. This procedure produced a stable solution of tTrx. Purification of tTrx from this protein solution required anion exchange chromatography followed by gel permeation in a HPLC system to obtain fully purified, recombinant tTrx which allowed further characterisation studies to be undertaken. An initial investigation into tTrx was performed to determine some basic physical, biochemical and functional aspects of this hitherto relatively undefined protein. Analysis by sedimentation equilibrium indicated that freshly prepared tTrx forms a single species with a molecular weight of 18.8kDa. This value indicates that recombinant tTrx naturally forms a dimer in solution that was shown to be non-covalent in nature and stable in solution. The capacity of tTrx to reduce protein disulphide bonds was determined using the insulin reduction assay. Results show that tTrx lacks this particular redox ability. The rate of oxidisation at 4 degrees C was analysed using free thiol determination, sedimentation equilibrium and SDS-PAGE patterning. Results indicated a steady rise in the degree of oxidation of tTrx over an eight day period. After six days the oxidated protein consistently displayed the presence of intramolecular disulphide bonds. Covalently-linked disulphide dimers and higher molecular weight oligomers were detectable after eight days oxidation. An investigation of the reducing capacity of the basic Trx system determined that fully oxidised tTrx was unable to act alone as a substrate for thioredoxin reductase (TR). However, when reduced Trx was added to the system, it appeared capable of acting as an electron donor to the oxidised tTrx in order to reduce disulphide groups. Recombinant tTrx was successfully radiolabelled with Trans 35S-methionine/cysteine for use in cell association studies. No evidence was found to indicate the presence of a receptor for tTrx on either MCF-7 or U-937 cells. Findings suggest that a low level of non-specific binding of tTrx to these cell lines rather than a classical ligand-binding mechanism occurs thus suggesting the absence of a cell surface receptor for tTrx. The role that Trx may play in the cellular responses to oxidative stress was also investigated. The chemical oxidants hydrogen peroxide (H2O2) and diamide were used to establish an in vitro model of oxidative stress for the choriocarcinoma cytotrophoblast cell line JEG-3. Cellular function was assessed in terms of membrane integrity, metabolic activity and the ability to synthesis new DNA following exposure to these oxidants. Results indicated that both agents were capable of causing cells to undergo oxidative stress without inducing immediate apoptosis or necrosis. Initially, JEG-3 cells exposed to 38μM or 75μM H2O2 or 100μM diamide were shown to display altered cell metabolism and DNA synthesis without loss to cell viability or membrane integrity. Cells were also shown to be capable of some short-term recovery but later lapsed into a more stressed state. Expression levels of Trx were studied to determine whether this type of chemical stress caused a change in intercellular protein levels. Both cELISA and western blotting results indicated that only cells exposed to 100μM diamide displayed any significant increase in Trx protein levels after 6 or 8hrs exposure to the oxidant. Further studies over a longer time-frame were also performed. These found that when JEG-3 cells were exposed to 18μM H2O2 or 200μM diamide over 12-48hrs, a positive correlation between increasing endogenous Trx protein levels and a decline in cell proliferation was observed. Cytotrophoblast cells, which are responsible for implantation and placentation, are susceptible to oxidative stress in vivo and their anti-oxidant capacity is fundamental to the establishment of pregnancy. The findings obtained during these studies suggest that Trx plays a role in this process.
Thesis (Masters)
Master of Philosophy (MPhil)
School of Health Sciences
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3

Kerkmann, Heiko. "Differentielle Interaktionen hochpotenter Lokalanästhetika mit TTX-sensitiven und TTX-resistenten Natriumströmen an Spinalganglienzellen der erwachsenen Ratte." Wettenberg : VVB Laufersweiler, 2005. http://deposit.d-nb.de/cgi-bin/dokserv?idn=978034708.

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Iakovleva, Irina. "Selection of transthyretin amyloid inhibitors." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123939.

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Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). ATTR occurs through the aggregation of either wild-type plasma protein transthyretin (TTR) or a mutated form. TTR is a homotetramer that under normal circumstances functions as a carrier of thyroxine and retinol binding protein. The aggregation cascade requires dissociation of the tetramer into monomers, and preventing this dissociation represents a potential mode of intervention. Interestingly, small molecules, referred as kinetic stabilizers, can bind to TTR’s thyroxine-binding site (TBS) and such molecules are currently being used as a therapeutic approach to impair tetramer dissociation. The efficacy of TTR stabilization is directly correlated to the binding affinity of the ligand to TBS. However, the binding of the ligand to TTR in vivo can be affected by other plasma components resulting in poor efficacy. Thus, the selectivity of ligands is an important parameter. We have designed an assay where the ability to stabilize TTR can be directly evaluated in plasma and we have investigated the stabilizing effect of nine potential TTR binders (Paper I). The results, surprisingly, revealed that the binding affinity of molecules has a poor correlation to its selectivity. However, the nature of protein-ligand complex formation can also be described by enthalpic (∆H) and entropic (∆S) energy contributions. ∆H represents the change in chemical bonds and frequently requires a higher order of orientation compared to the ∆S component, which mainly represents the hydrophobic effect via the exclusion of water. We hypothesized that ligands possessing high ΔH in binding to their co-partner would also be more specific in a complex environment such as plasma. By applying a thermodynamic analysis using isothermal titration calorimetry, we found that the selectivity in plasma correlates well with the ∆H contribution and might, therefore, be a better predictor for selectivity. Luteolin was found to be a highly selective stabilizer of TTR and was investigated further (Paper II). The ligand displayed a significant rescuing effect in both cell culture and animal models. However, luteolin undergoes rapid enzymatic degradation in the liver and this impairs its use as a potential therapeutic drug. To attempt to circumvent this issue, we modified the most exposed hydroxyl group thus rendering the molecule inert towards glucuronidation (Paper III). The substitutions resulted in higher stability in the face of hepatic degradation molecules, but they also affected the selectivity in a negative manner. The screening for new TTR stabilizers resulted in the discovery of tetrabromobisphenol A, which displayed a very high selectivity (Paper IV). This study also included a comparison with the drug Vyndaqel™ which currently is in clinically use, and showed how the dosage could be altered to acquire a better level of saturation and possibly also a better clinical effect. Taken together we present new molecules with the ability to stabilize TTR, and these can serve as scaffolds for the design of new drugs. We present a method to measure the efficacy of a TTR-stabilizing drugs in a complex matrix and as well as a way to adjust the dosage of existing drugs. We also show that the selectivity of a drug is affected by the relative proportion of ∆H and ∆S, and this is of interest for drug design in general.
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Kerkmann, Heiko [Verfasser]. "Differentielle Interaktionen hochpotenter Lokalanästhetika mit TTX-sensitiven und TTX-resistenten Natriumströmen an Spinalganglienzellen der erwachsenen Ratte / Heiko Kerkmann." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1069740705/34.

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Pullmann, Martin. "Dynamische Blockierung TTX-resistenter Natriumkanäle durch Lokalanästhetika." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969813872.

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Panenic, Robert. "TTX-induced disuse of mammalian skeletal muscle." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59523.

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Previous reports of the effects of tetrodotoxin (TTX)-induced muscular disuse have demonstrated alterations in muscle force, speed, and fatiguability that might suggest changes in the quality of contractile proteins. These studies were extended to the effects of TTX-induced disuse on the Ca$ sp{2+}$-activation characteristics of myofibrillar ATPase of the rat gastrocnemius. Atrophic responses after TTX treatment were as previously reported with a significant decrease in left gastrocnemius weight (g) compared to the control-pump (C) group (1.25 $ pm$ 0.04 for C vs 0.72 $ pm$ 0.04 for TTX, X $ pm$ SEM, p $ leq$ 0.01). Myofibrillar protein yield (mg$ cdot$g$ sp{-1}$ wet weight) was also depressed (92.8 $ pm$ 4.6 for C vs 70.3 $ pm$ 3.7 for TTX; p $ leq$ 0.01). Maximum ATPase of myofibrils (nmol Pi$ cdot$mg$ sp{-1} cdot$min$ sp{-1}$) was decreased (424 $ pm$ 46 for C vs 199 $ pm$ 27 for TTX, p $ leq$ 0.01). Furthermore, the Hill n which reflects the cooperative aspects of Ca$ sp{2+}$-activation of the myofibrillar ATPase was significantly depressed (1.58 $ pm$ 0.07 for C vs 1.29 $ pm$ 0.09 for TTX; p $ leq$ 0.05) after TTX treatment. The results of the present study suggest that muscle perturbations that result from TTX-induced disuse are at least partially related to changes in the myofibrillar fraction.
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Kerkmann, Heiko [Verfasser]. "Differentielle Interaktionen hochpotenter Lokalanästhetika mit TTX-sensitiven und TTX-resistenten Natriumströmen an Spinalganglienzellen der erwachsenen Ratte / vorgelegt von Heiko Kerkmann." Wettenberg : VVB Laufersweiler, 2005. http://d-nb.info/978034708/34.

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9

Azevedo, Ana do Carmo Ramalho Moreira. "Familial amyloid polyneuropathy: TTR sequencing and "in silico" analysis." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15608.

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Mestrado em Biomedicina Molecular
Familial amyloid polyneuropathy (FAP) or paramiloidosis is an autosomal dominant neurodegenerative disease with onset on adult age that is characterized by mutated protein deposition in the form of amyloid substance. FAP is due to a point alteration in the transthyretin (TTR) gene and until now more than 100 amyloidogenic mutations have been described in TTR gene. FAP shows a wide variation in age-at-onset (AO) (19-82 years, in Portuguese cases) and the V30M mutation often runs through several generation of asymptomatic carriers, before expressing in a proband, but the protective effect disappear in a single generation, with offspring of late-onset cases having early onset. V30M mutation does not explain alone the symptoms and AO variability of the disease observed in the same family. Our aim in this study was to identify genetic factors associated with AO variability and reduced penetrance which can have important clinical implications. To accomplish this we genotyped 230 individuals, using a directautomated sequencing approach in order to identify possible genetic modifiers within the TTR locus. After genotyping, we assessed a putative association of the SNPs found with AO and an intensive in silico analysis was performed in order to understand a possible regulation of gene expression. Although we did not find any significant association between SNPs and AO, we found very interesting and unreported results in the in silico analysis since we observed some alterations in the mechanism of splicing, transcription factors binding and miRNAs binding. All of these mechanisms when altered can lead to dysregulation of gene expression, which can have an impact in AO and phenotypic variability. These putative mechanisms of regulation of gene expression within the TTR gene could be used in the future as potential therapeutical targets, and could improve genetic counselling and follow-up of mutation carriers.
A Polineuropatia amiloidótica familiar (FAP) ou paramiloidose é uma doença neurodegenerativa autossómica dominante com início na vida adulta sendo caracterizada pela deposição da proteína mutada na forma de substância amilóide. A FAP é devida a uma mutação pontual no gene transtirretina (TTR) e até agora mais de 100 mutações amiloidogénicas foram descritas neste gene. A FAP apresenta uma grande variação na idade de início (AO) (19-82 anos, nos casos portugueses) e a mutação V30M pode segregar através de várias gerações de portadores assintomáticos, antes de se expressar num probando. No entanto, este efeito protetor pode desaparecer numa única geração, com os filhos de casos tardios a apresentarem um início precoce. A mutação V30M não explica por si só os sintomas e a variabilidade da AO observada dentro de uma mesma família. O nosso objetivo neste trabalho foi identificar fatores genéticos associados com a variabilidade da AO e a penetrância reduzida. De modo a cumprir este objetivo genotipámos 230 doentes, por sequenciação automática, para identificar possíveis modificadores genéticos dentro do locus da TTR. Após a genotipagem, investigamos uma possível associação dos SNPs encontrados com a AO e realizamos uma intensiva análise in silico de modo a perceber uma possível regulação da expressão génica. Apesar de não termos encontrado nenhuma associação entre os SNPs e a AO, encontrámos resultados não descritos e muito interessantes na análise in silico dado termos observado algumas alterações a nível do mecanismo de splicing, ligação de fatores de transcrição e ligação de miRNAs. Todos estes mecanismos quando alterados podem levar à desregulação da expressão do gene, o que pode ter um impacto na AO e variabilidade fenotípica. Estes mecanismos hipotéticos da regulação da expressão génica no gene da TTR podem ser úteis para no futuro serem aplicados como potenciais alvos terapêuticos, beneficiando o aconselhamento genético e o follow-up dos portadores da mutação.
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Lobato, Luísa Maria Correia Lopes. "A nefropatia na Polineuropatia Amiloidótica Familiar de Tipo Português (TTR V30M)." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2003. http://hdl.handle.net/10216/63699.

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Books on the topic "TTrx"

1

Maria, Adolfo. Na terra dos TTR. [Lisboa]: Edições Colibri, 2014.

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Wyatt, Ian Tony. O gmundar tha ttr Dytts. Birmingham: University of Birmingham, 1989.

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Sabin, Vlad, and Institutul de Lingvistică și Istorie Literară "Sextil Pușcariu", eds. Tezaurul toponimic al României,Transilvania (TTRT): Valea Ierii. București: Editura Academiei Române, 2010.

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Casdorph, David G. The freight car data book: Trailer Train Company, TTX Company. [Monrovia, CA]: Society of Freight Car Historians, 1995.

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Cowper-Benoit, Gail. Comparison of TTX- and denervation-induced disuse on rat plantaris myofibrillar proteins. Sudbury, Ont: Laurentian University, Chemistry and Biochemistry Department, 1992.

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Travel and Tourism Research Association. Annual Conference. Proceedings of the Travel Research Workshop: Papers presented at the TTRA sixteenth annual conference, Palm Springs, California, June 9-12, 1985. [S.l.]: Travel and Tourism Research Association, 1985.

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International, Symposium on Familial Amyloidotic Polyneuropathy and Other TTR Related Disorders (3rd 1995 Lisbon Portugal). Abstracts from the third International Symposium on Familial Amyloidotic Polyneuropathy and Other TTR Related Disorders: 2nd International Workshop on Liver Transplantation in FAP ; held in Lisbon, 27-29 October 1995. London: Pergamon, 1996.

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Casdorph, David. Intermodal Well Car Directory TTX Fleet. Modern Transport History Press, 2011.

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Casdorph, David. Intermodal Well Car Directory Non-TTX Operators. Modern Transport History Press, 2011.

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Rothstein, Kristian. Composition Notebook: Ttrs Sports Car Journal Notebook Blank Lined Ruled 6x9 100 Pages. Independently Published, 2020.

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Book chapters on the topic "TTrx"

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Cooper, Robin. "Perception, Types and Frames." In Language, Cognition, and Mind, 165–77. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-50200-3_8.

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AbstractWe present a view of perception as the classification of objects and events in terms of types in the sense of TTR, a Type Theory with Records. We argue that such types can be used to give a formal model of concepts and cognitive processing involving concepts. This yields a view that natural language semantics is based on our cognitive perceptual ability. The paper provides an overview of some key ideas in TTR including the important notion of record type. We suggest that record types can be used to model frames in a way that relates to the Düsseldorf notion of frame as well as those of Fillmore and Barsalou.
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Liu, Jiandong, and Robert G. Wilhelm. "Genetic Algorithms for TTRS tolerance analysis." In Geometric Product Specification and Verification: Integration of Functionality, 73–82. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-017-1691-8_8.

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Salvi, F., R. Plasmati, R. Michelucci, P. Zonari, A. Ferlini, M. R. Almeida, P. P. Costa, et al. "Clinical Characterization of a New TTR Variant in an Italian Family: TTR ALA 49." In Amyloid and Amyloidosis 1990, 603–6. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3284-8_148.

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Johnson, Steven M., Luke Wiseman, Johan F. Paulsson, Sungwook Choi, Evan T. Powers, Joel N. Buxbaum, and Jeffery W. Kelly. "Understanding and Ameliorating the TTR Amyloidoses." In Protein Misfolding Diseases, 967–1003. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470572702.ch45.

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Giglio, A., M. Carestia, A. D’Ambrogio, D. Di Giovanni, P. Gaudio, and A. Malizia. "A Framework for TTX Specification and Evaluation." In Enhancing CBRNE Safety & Security: Proceedings of the SICC 2017 Conference, 409–16. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-91791-7_47.

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Villaseñor, Luis. "Data Acquisition System for the GEM TTR." In Supercollider 5, 881–84. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2439-7_206.

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Amade, Philippe, Mohamed Mehiri, and Richard J. Lewis. "Outstanding Marine Biotoxins: STX, TTX, and CTX." In Outstanding Marine Molecules, 23–44. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527681501.ch02.

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Valade, C., and A. Riviere. "The TTRE: Micro tolerancing Model for CAD-CAM Modelers." In Integrated Design and Manufacturing in Mechanical Engineering, 339–48. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5588-5_34.

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Rückert, J. C., H. Sobel, M. Egert, and J. M. Müller. "Standardisierte Analyse der thorakoskopischen Thymektomie (tThx) bei Myasthenia gravis (MG)." In Zurück in die Zukunft, 695. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55611-1_502.

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Pirelli, Blagovesta, and Alain Wegmann. "Technology-Transfer Requirements Engineering (TTRE) – on the Value of Conceptualizing Alternatives." In Lecture Notes in Computer Science, 249–59. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-01391-2_30.

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Conference papers on the topic "TTrx"

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Cheng, Yongming, Lixin Xu, and Paul Stanton. "Design Challenges of Top Tensioned Risers in Ultra Deepwater Applications." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-50127.

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A Top Tensioned Riser (TTR) system provides direct access to subsea wells from a floating platform for drilling, workover, and completion operations. TTRs have been widely used with floating production systems such as Spars and TLPs in deepwater field developments. This paper investigates design challenges of TTRs in ultra deepwater applications. As application moves to ultra deepwater, challenges of TTRs increase in terms of riser design, analysis, installation and global performance. This paper first introduces a typical TTR configuration in ultra deepwater applications. The TTR design issues cover riser wall thickness which is especially driven by extreme high pressure and high temperature, tension limits, high payload, and long tensioner stroke. The installation concerns come from hook capacity limit, riser Vortex-Induced Vibration (VIV) when the riser is disconnected, and riser bottom drift caused by vessel motion during installation. This paper further investigates the coupling between the risers and floating platform, the interference between riser pairs, riser VIV, and tensioner stick-slip phenomenon. Examples are given to illustrate various aspects of TTRs in ultra deepwater applications. In addition, this paper also explores likely solutions to TTR design challenges.
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Deka, Dhyanjyoti, Mike Campbell, Vinayak Patil, Michael Long Ge, Steve Wong, and Tim Frame. "TRACS JIP – TTR Life Extension Process." In Offshore Technology Conference. OTC, 2021. http://dx.doi.org/10.4043/31060-ms.

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Abstract The Tensioned Riser Assessment for Continued Service (TRACS) JIP develops a structured life extension process for TTR systems including single casing, dual casing, buoyancy can supported and tensioner supported TTRs. The JIP bridges regulatory and API frameworks and achieves industry consensus on analysis, inspections, and documentation. The life extension process developed in this JIP consists of detailed roadmaps that guide the operator through the different assessment steps starting from initial data gathering through to the development of the forward-looking IMP. The JIP life extension process is based on a threat assessment philosophy which ensures identification and assessment of all possible threats to the integrity of the TTR in its extended life. The JIP process is validated against three real life TTR systems that are nearing the end of their design lives. Potential threats to the integrity of these TTRs during the projected continued service beyond the design life are identified and specific inspection and analysis recommendations to safely manage or mitigate these threats are made. The JIP also provides TTR life extension analysis guidance while considering the opportunities to reduce conservatism compared to new designs. Inspection of TTRs is challenging due to accessibility issues and the pipe in pipe construction. Several subsea NDE inspection tools are surveyed in this JIP and their applicability to TTRs is discussed.
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Cheng, Yongming, Kostas F. Lambrakos, Roger Burke, and Paul Stanton. "Time Domain VIV Prediction for Top Tensioned Risers." In ASME 2010 29th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/omae2010-20100.

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Top Tensioned Risers (TTRs) have been widely used with floating production systems such as Spars and TLPs in deepwater field developments. A TTR system provides direct access to subsea wells from a floating platform for drilling, workover, and completion operations. It is often subjected to Vortex-Induced Vibration (VIV) caused by ambient ocean currents or vessel motions. This paper investigates time domain VIV prediction for TTRs used in a typical Spar floating production system. A typical TTR has strong nonlinear and time-varying dynamic characteristics. The existing gaps between the riser and keel guide and between riser top centralizers and the supporting conductor result in intermittent VIV behaviors of the riser. In addition, hydraulic tensioners are widely used to provide tension to a TTR. The tension from tensioners varies with the riser’s dynamic response especially in the vertical direction. The time domain approach, which has been benchmarked and published in about ten technical papers, is thus more appropriate to predict TTRs’ VIV performance than a frequency domain method. This paper first introduces a typical TTR structure and then presents the analysis methodology and features of the time domain VIV prediction program ABAVIV. An example TTR is used to illustrate intermittent VIV behaviors such as top tension, interaction load at the keel guide, and VIV response at the location of top centralizers. This paper further studies the sensitivity of the VIV response to different current profiles. It finally uses the time domain approach to analyze the VIV response of the riser with its boundary conditions fixed and compares the results with those from a frequency domain program. A conclusion is finally drawn about the use of time domain VIV prediction for Spar TTRs.
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Frazer, G. Ross, Daniel Reagan, Wolfgang Ruf, and Jun Cheng. "Top Tension Riser Fatigue Monitoring System." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49181.

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ATP Oil and Gas Corporation (ATP) is utilizing the MinDOC 3 vessel design for their Mirage, Morgus and Telemark fields. The modeling techniques utilized during the design and verification stages of the project suggest that the production top tension risers (TTR) may be affected by a phenomenon known as Wake Induced Oscillation (WIO). The current modeling techniques are insufficient at predicting the expected amplitude the TTRs will experience due to the WIO and what effect the occurrence will have on the overall fatigue performance of the TTR’s. To acquire a thorough understanding of the effects of WIO, ATP has prudently undertaken an extensive assurance initiative with the purpose of assessing and maintaining structural integrity of their TTRs. As part of ATP’s Integrity Management (IM) program, ATP is monitoring localized strain as well as the motion response of the riser at discrete locations. The paper presents, in detail, ATP’s real-time TTR monitoring system deployed on the ATP MinDOC 3 vessel for their Telemark field. Specific topics to be covered are the monitoring system configuration drivers such as; monitoring objectives, instrumentation requirements, specification, and installation. The paper will cover the number and location of monitoring devices and justification for selection. The data acquired will provide state-of-the-art full-scale riser response information especially during significant events such as hurricanes and loop currents. The goals of the project are: 1. To gain a more in depth understanding of WIO with respect to large diameter hull columns and smaller diameter production TTR’s; 2. Bolster the understanding of the fundamental hydrodynamic behaviour of TTRs and, specifically, vessel-motion induced response of TTRs, and VIV of the TTRs with varying levels of strake fouling. 3. To accurately assess the role of WIO in fatigue damage to the TTR(s).
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Mousavi, Mir Emad, Sanjeev Upadhye, and Kevin Haverty. "Simplified Strength Reliability and Integrity Analysis of TTRs." In ASME 2014 33rd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/omae2014-24289.

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The design of riser systems can be improved if structural reliability methods are used to assess their safety and integrity and confirm that such design meets a target annual probability of failure. TTRs are typically multi–bore assemblies involving several sub-assemblies. The failure of any of the components of a TTR under extreme or service environmental conditions can lead to an immediate failure of the entire assembly and impose a direct risk of damaging the wellheads, conductors, casing and tubing hangers, or other subsea equipment, because they are installed directly on top of the wellhead. However, the actual strength safety of the TTR cannot be examined unless after it is installed and examined under extreme events. Because of the numerous uncertainties associated with the design of TTRs, a probabilistic approach based on structural reliability methods can account for many of those uncertainties and serve as a basis for their reliable and cost-effective design. In turn, a comprehensive reliability assessment of a TTR requires extensive analysis that is considerably more complex and time consuming compared to a conventional deterministic-based analysis. This paper presents a probabilistic-based simplified methodology for the strength reliability assessment of TTR systems. In this method, marginal values on some uncertain model inputs are considered similar to the conventional analysis methods but, some key random variables related to environmental demands and component capacities are considered with their associated probability distributions. As a result, this method can be used to estimate the minimum level of safety of the TTR under extreme events. Additionally, results of the proposed method are discussed for integrity analysis and integrity-based optimal design of the TTR system, which compare the safety of the TTR components and estimate the component Optimality Factors for improving the design integrity and meeting a target minimum annual probability of failure.
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Tang, Yougang, Liyuan Wang, Yangqing Li, and Zhongbai Liu. "The Dynamic Response Induced by the Random Heave of Platform and Vortex for TTRs." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-10203.

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The dynamic responses of TTRs in the deep water were studied considering coupled the random heave of platform and VIV. The random parametric excitation is set up considering the random motion of platform. The vortex lift force is calculated with the time-varying lift coefficient based on the Van der Pol drafting oscillator model. The equation of coupled VIV and parametric excitation vibration (PEV) is established and the program of solving coupled PEV and VIV is developed. The coupled dynamic response induced by random parametrical excitation and VIV is calculated for the TTR of Truss Spar, and the dynamic characteristics are investigated. The results show that the random parametrical excitation can magnify the dynamic response of TTRs, and it will change the main frequency of TTRs vibration.
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Koska, Ryan, Jim Kaculi, Mike Campbell, and Darren Mills. "Minimizing Interference Between Top Tension Risers for Tension Leg Platforms." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-11182.

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Interference between TTRs is a key design challenge. For spars, this is typically mitigated by having a large spacing between wellheads, thus increasing the distance between risers along the water depth. However, due to lower TTR tensioner stroke limits combined with larger vessel offsets, the feasibility of spacing out the wellheads for TTRs on a TLP is limited. The result is TTRs that are closer together through depth and therefore more likely to contact each other in extreme current conditions. This paper presents the approach used to minimize the interference between the top tension risers on TLPs. Specific topics include considering current profiles with varying directions through the water depth, adjusting the top tension of the risers, and utilizing low-drag vortex-induced vibration (VIV) suppression strakes. The relative effect of each of these topics is also discussed.
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Mercan, Bulent, Mike Campbell, and Clay Thompson. "Fatigue Monitoring and Life Extension for Top Tensioned Production Riser Systems." In Offshore Technology Conference. OTC, 2021. http://dx.doi.org/10.4043/31259-ms.

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Abstract Top tensioned production riser (TTR) systems are exposed to fatigue loading in deep water as a result of vessel motions and high currents. The accuracy of predictions of the in-place fatigue response, which is a key input for any life extension requests, is dependent on the operating condition during the life of field including fluid contents and top tension. One solution to reduce this uncertainty is to deploy a fatigue monitoring system to assure the long-term integrity and performance of these riser systems. This paper presents results from a recent TTR monitoring campaign and focuses on the impact of top tension variation on riser motion and fatigue response in the field. Standalone and ROV deployable motion loggers offer a low cost and robust method of fatigue monitoring. The motion loggers are installed at discrete locations along the TTR to measure riser motions and then determine fatigue accumulations. During one of the recent monitoring campaigns, riser top tension was changed due to operational requirements, which in turn affected the riser fatigue response in the field. Field data is collected from two periods for two TTRs. The top tension was adjusted between each campaign allowing the effect of tension on riser fatigue response to be better understood using field measurements. The resulting riser motions and fatigue accumulations will be presented to demonstrate the sensitivity to top tension and highlight the importance of maintaining good records during the field life. Currently, there is no single guideline in the US that addresses TTR life-extension programs in detail. The results from this monitoring program are one step forward in better understanding system behavior of deep water TTRs and assessing the feasibility of an extended service life.
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Chen, Cheng-Yo, and Prahoro Nurtjahyo. "Numerical Prediction of Spar Motions Considering Top Tension Riser Stiffness." In ASME 2004 23rd International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2004. http://dx.doi.org/10.1115/omae2004-51289.

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Spar motions are often predicted without explicitly considering the stiffness effect of the buoyancy can of top tension risers (TTRs). This may result from the inability of most motion prediction programs to take this effect into consideration. The forces exerted by the TTR buoyancy can on the spar provide a net beneficial righting moment. Hence, neglecting the effect of TTR stiffness could produce excessive predicted spar motions, particularly maximum pitch angle. The derived spar configurations based on such predicted motions are likely to be conservative and not optimal. This paper proposes a simple “Linearized P-Delta” model to account for the effect of TTR stiffness on spar motions. The predicted motions using the proposed model are compared with the model test results for a production truss spar in the Gulf of Mexico. The comparison results indicate that the proposed model is quite rigorous and correlates reasonably well with the model test results.
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Zhang, Hanqing, and Derek Smith. "Interference of Top Tensioned Risers for Tension Leg Platforms." In ASME 2017 36th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/omae2017-61334.

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Dry tree top-tensioned risers (TTRs) are widely used on floating production systems such as TLPs and Spars for drilling, completion, workover and production. The interference between neighboring TTRs is an important consideration which has a direct impact on the total TTR payload budget and the wellbay size for floater sizing and cost. Since the realistic sizing of a floater is essential towards the concept selection process for a field development, TTR interference should be addressed at the early stages of an offshore oilfield development. If the floater is a tension leg platform (TLP) and the field has strong current with associated extreme waves, riser interference may be very challenging and can have direct impact on riser design and the sizing and layout of the TLP. The waves and the oscillating motions of the TLP will have effects on riser interference. The oscillating motion of the TLP can excite the vibrational motion of the risers, and the wave-induced velocity of water particles and the motions of the risers with the movement of the TLP increases the relative flow acting on each riser. The combined effects will increase the deflection of the risers and thus the likelihood of riser interference. The industry has not seen an acceptable interference analysis approach yet which can account for the combined effects of current, waves, and TLP motions. This paper proposes two engineering approaches for the interference analysis of top tensioned risers for tension leg platforms with the combined effects of current, surface waves, and associated floater motions being addressed.
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Reports on the topic "TTrx"

1

Cipriani, Ralph J. TTR Sub-Area Plan. Office of Scientific and Technical Information (OSTI), March 2016. http://dx.doi.org/10.2172/1561161.

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Morrison, Robert. DOE Occurrence Report - Legacy Depleted Uranium (DU) Discovered on TTR Lakebed (subsurface). Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1670253.

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Witt, D. C. Am/Cm TTR testing -- 3/8-inch glass beads evaluation in CIM5[Technical Task Request]. Office of Scientific and Technical Information (OSTI), January 2000. http://dx.doi.org/10.2172/750865.

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Mark Krauss. Closure Report for Corrective Action Unit 408: Bomblet Target Area Tonopah Test Range (TTR), Nevada, Revision 0. Office of Scientific and Technical Information (OSTI), September 2010. http://dx.doi.org/10.2172/990672.

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VINER, BRIAN. RADIONUCLIDES OF THE SAVANNAH RIVER SITE ENVIRONMENT: RECENT DATA AND MONITORING TECHNIQUES IN SUPPORT OF WAES TTX#3. Office of Scientific and Technical Information (OSTI), October 2020. http://dx.doi.org/10.2172/1673317.

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Matthews, Patrick. Closure Report for Corrective Action Unit 413: Clean Slate II Plutonium Dispersion (TTR) Tonopah Test Range, Nevada, Revision 0. Office of Scientific and Technical Information (OSTI), October 2018. http://dx.doi.org/10.2172/1496629.

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Matthews, Patrick. Closure Report for Corrective Action Unit 412: Clean Slate I Plutonium Dispersion (TTR) Tonopah Test Range, Nevada, Revision 0. Office of Scientific and Technical Information (OSTI), August 2016. http://dx.doi.org/10.2172/1330101.

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Author, Not Given. Addendum to the Closure Report for Corrective Action Unit 412: Clean Slate I Plutonium Dispersion (TTR), Tonopah Test Range, Nevada. Office of Scientific and Technical Information (OSTI), January 2018. http://dx.doi.org/10.2172/1466410.

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Wright, Emily D., and Matthew Cattaneo. Causal Analysis Report for ?Demolition of Historic and Yet-to-be-Determined Radar Towers at TTR Without Completing Required NEPA Process?. Office of Scientific and Technical Information (OSTI), April 2018. http://dx.doi.org/10.2172/1483199.

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Matthews, Patrick, Mark Burmeister, and Patricia Gallo. Corrective Action Investigation Plan for Corrective Action Unit 413: Clean Slate II Plutonium Dispersion (TTR) Tonopah Test Range, Nevada, Revision 1. Office of Scientific and Technical Information (OSTI), April 2016. http://dx.doi.org/10.2172/1257276.

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