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1
Nasta, Rodolphe. "TELECOMMUNICATION SATELLITE TELEMETRY TRACKING AND COMMAND SUB-SYSTEM." International Foundation for Telemetering, 1998. http://hdl.handle.net/10150/607355.
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International Telemetering Conference Proceedings / October 26-29, 1998 / Town & Country Resort Hotel and Convention Center, San Diego, California<br>This paper gives an overview on Telemetry, Tracking and Command (TTC) sub-system
that are used onboard some telecommunication satellites. Then, a description of the
equipments of such a sub-system is given, together with the main performances.
2
Fiebig, U. C., and R. Schweikert. "PN CODES FOR USE IN TTC SPREAD-SPECTRUM MULTIPLE-ACCESS SYSTEMS." International Foundation for Telemetering, 1990. http://hdl.handle.net/10150/613818.
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International Telemetering Conference Proceedings / October 29-November 02, 1990 / Riviera Hotel and Convention Center, Las Vegas, Nevada<br>Various PN codes for use in TTC spread-spectrum systems are considered. The evaluation is based on peak magnitudes and amplitude distributions of both the even and the odd autocorrelation and crosscorrelation functions. Furthermore the influence of the phase of a sequence on the correlation parameters is studied, multiple-access characteristics in terms of the total interference parameter are evaluated and synchronous as well as asynchronous code generation is considered.1
3
Viljoen, Gerhardus Petrus. "The development and implementation of new TTC flotation chemicals / Gerhardus Petrus Viljoen." Thesis, Potchefstroom University for Christian Higher Education, 1998. http://hdl.handle.net/10394/9716.
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Batch floats were done on Merensky ore from Section 10 at Impala Platinum. The
ultimate objective of this project was a pilot plant trial and certain questions had to be
answered before the trial could be conducted. To circumvent decomposition of
trithiocarbonates (TIC's) in water, tablets, solvents and emulsions were prepared and
tested as carriers of TIC's in the flotation system. The emulsion gave the best result.
The decomposition rate of short chain ionic and covalent collectors in water were
measured. In water iC3-TIC was less stable and decomposed faster than the
corresponding xanthates.
Long and short chain ionic TTC's, covalent TTC and long chain mercaptans were
evaluated and compared to the standard collector. iC3-TTC dosed in an emulsion
showed significant improvement on the standard at Impala Platinum. Combinations of
the collectors also showed good results. Mineral potential data for the TTC's differed
from xanthates. The TIC dosed as a powder or in emulsion showed a two step drop in
potential. At this stage the only conclusion from this is that xanthates and TTC have a
different mechanism of adsorption.
Three collectors were chosen for testing on a continuous 60 litre cell at Impala Platinum.
iC3-TTC dosed in water and the emulsion were compared to the standard collector. A
2.8% and 5% improvement on PGM and nickel recovery was observed with the
emulsion.<br>Thesis (MIng)--Potchefstroom University for Christian Higher Education, 2000
4
Zhao, Liang. "Multi-area network analysis." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1482.
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After the deregulation of the power systems, the large-scale power systems may contain
several areas. Each area has its own control center and each control center may have its
own state estimator which processes the measurements received from its local
substations. When scheduling power transactions, which involve several control areas a
system-wide state estimation solution is needed. In this dissertation, an estimation
approach which coordinates locally obtained decentralized estimates while improving
bad data processing capability at the area boundaries is presented. It is assumed that
synchronized phasor measurements from different area buses are available in addition to
the conventional measurements provided by the substation remote terminal units. The
estimator with hierarchical structure is implemented and tested using different
measurement configurations for two systems having 118 and 4520 buses. Furthermore,
we apply this multi-area solution scheme to the problem of Total Transfer Capability
(TTC) calculation. In a restructured power system, the sellers and buyers of power
transactions may be located in different areas. Computation of TTC will then require
system-wide studies. We investigate a multi-area solution scheme, which takes
advantage of the system-wide calculated Power Transfer Distribution Factors (PTDF) in
order for each area to calculate its own TTC while a central entity coordinates these
results to determine the final value. The proposed problem formulation and its solution
algorithm are presented. 30 and 4520 bus test systems are used to demonstrate the
approach and numerically verify the proposed TTC calculation method.
5
MARTINELLI, PAOLA. "Codifica e modulazione per una maggiore robustezza al Jamming del collegamento satellitare TTC." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/214223.
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6
Karjalainen, M. (Marika). "Optimizing reaction conditions for an LPMO-enzyme from Trichoderma reesei with a downscaled TTC-assay." Master's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201711293191.
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<div lang="en" class="abs">
Abstract
The increasing awareness of the causes and consequences of climate chance has led to actions to reduce the dependency on oil and other finite energy and raw material sources. Plant biomass is used in increasing amounts as a resource for biofuel, biochemical and fiber production. Carbohydrate enzymology has provided new ways to utilize and modify renewable carbon sources, especially the lignocellulolytic systems of fungi. Cellulolytic enzymes work in a synergistic manner on recalcitrant structure of cellulose, hydrolyzing it into soluble oligosaccharides, and eventually, glucose. Lytic polysaccharide monooxygenases (LPMOs) contribute to this system by oxidizing either C1- or C4-carbon from the carbohydrate chain on a crystalline cellulose with the help of copper-core induced radicals, thus creating available substrates for the other cellulolytic enzymes. Since their discovery in 2010, the research on their activities and specificities have increased rapidly, but the analytical methods to investigate this diverse group of enzymes is mostly limited to short and soluble products, which are only a fraction of the oxidation products. In addition, most of the methods require special equipment, wide range of standards and expertise to interpret the results. In this study, HPLC and HPAEC-PAD were tested, unsuccessfully, to quantify soluble products from LPMO-catalysis. A TTC-method, in which 2,3,5-triphenyl-2H-tetrazolium chloride is reduced into red and spectrophotometrically quantifiable formazan by reducing ends from insoluble LPMO-products, was successfully optimized and downscaled, and used to optimize reaction conditions for a type 3 LPMO from Trichoderma reesei, TrAA9A, with Whatman filter paper 1 as a substrate. Experiments were conducted to investigate the effects of pH, temperature, donor, time and the presence/absence of H₂O₂ to the accumulation of reducing ends. The results did not show any substantial differences in the accumulation of aldehydes in different reaction conditions. This study showed that cellulose degrades in the presence of TrAA9A and an electron donor. The greatest effects were observed with longer reaction times and the addition of H₂O₂, both increasing the amount of measured aldehydes in the insoluble products. The highest yield was recorded from the reactions with gallic acid as a donor at pH 6, and in the presence of 0.7 mM H₂O₂. The results from this study could lead to understanding the rate-limiting factors of the LPMOs and further improve the utilization of this enzyme in the degradation of lignocellulosic biomass.
7
Karunakaran, Chandrapriya. "Role of Cavitation during Bulk ultrasound Ablation: Ex vivo and In vivo Studies." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1343051845.
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8
Casas, Atala Mariana Victoria. "Caractérisation de modèles animaux pour l' étude des différents types de motoneurones." Paris 6, 2005. http://www.theses.fr/2006PA066014.
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9
Bensalem, Mohamed. "Développement d’imagerie THz de champs de teneur en eau et de température en vue de la caractérisation thermique et massique de coefficients de diffusions." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0176/document.
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Le mouvement d’humidité dans le réseau poreux de certains matériaux est très souvent à l’origine de phénomènes préjudiciables pour la durabilité des constructions du génie civil. C’est en particulier le cas pour le séchage du bois, générateur de fissures et de délaminations aux interfaces de collage, et pour le béton en situation d’incendie où le mouvement d’humidité peut induire des désordres irréversibles (écaillage). Le recours à des modèles prédictifs de ruine des structures nécessite donc la simulation du mouvement d’humidité au sein des matériaux. Ces modèles de transfert de masse et de chaleur sont sophistiqués et nécessitent d’être confrontés à des mesures afin d’être validés. Peu de techniques expérimentales existent pour mesurer les mouvements ou gradients d’humidité dans les réseaux poreux, en particulier en régime transitoire (séchage, incendie). Les techniques existantes sont de plus généralement coûteuses et imposent des conditions sévères de sécurité pour les chercheurs. L’objectif de la thèse est donc de mettre au point un dispositif de mesure de gradients d’humidité basé sur l’imagerie Térahertz. Il s’agit d’une technique de mesure relativement peu onéreuse et permettant de réaliser des mesures en régime transitoire. Un banc expérimental existant sera donc adapté à la mesure du champ d’humidité sur éprouvettes de bois en conditions thermo-hydriques variables, et sur éprouvettes de béton en situation de chauffage. Les résultats constitueront une base de données utile à la compréhension des phénomènes de dégradation des matériaux et seront directement utilisables comme outil de validation de modèles de calcul<br>The movement of moisture in the porous network of certain materials is very often at the origin of phenomena prejudicial to the durability of the constructions of the civil engineering. This is particularly the case for the drying of wood, which creates cracks and delaminations at bonding interfaces, and for concrete in situations of fire where the movement of moisture can induce irreversible disorders (chipping). The use of predictive models of structural ruin therefore requires the simulation of the moisture movement within the materials. These mass and heat transfer models are sophisticated and need to be confronted with measurements in order to be validated. Few experimental techniques exist to measure moisture movements or gradients in porous networks, especially in transient conditions (drying, fire). Existing techniques are often expensive and impose severe conditions of safety for the researchers. The objective of the thesis is therefore to develop a device for measuring gradients of moisture based on Terahertz imagery. This is a comparatively inexpensive measuring technique and makes it possible to carry out transient measurements. An existing experimental bench will therefore be adapted to the measurement of the moisture field on wood specimens under variable water-moisture conditions and on concrete specimens in a heating situation. The results will constitute a database useful for understanding the phenomena of degradation of materials and will be directly usable as a validation tool for calculation models
10
Baser, Abdul Jabar. "THE ROLE OF VISUAL AIDS IN TEACHING : A study of visual aids used by TTC teachers in two provinces of Afghanistan." Thesis, Karlstads universitet, Institutionen för pedagogiska studier, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-31081.
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This research is about the usage of visual aids in education which takes place in teacher training colleges (TTCs) of Afghanistan. The data is collected from two TTCs, Kabul and Wardak provinces. It covers a specific area, which is the use of visual aids during teaching and learning. The views of 100 teachers regarding usage of visual aids, providing visual aids, as well as male and female differences are considered and views of experienced and less experienced teachers are investigated. The necessary data is collected by using questionnaires. The responses of teachers’ show, that all of them use visual aids. Some teachers use less and some of them use more visual aids during teaching and learning. All respondents believe on the importance of using visual aids. Also the result shows that male and female teachers use the visual aids but, with some differences, as it is clearly shown in the findings some use one type, but some use other types. Kabul TTC teachers use more visual aids than Wardak province TTC teachers. In addition to that the important finding is the differences between experienced and less experienced teachers, the junior teachers use more visual aids than senior or experienced ones. These findings would not be generalized for the whole country. But it could be considered for the central region of Afghanistan, because the two TTCs are located in the central region of Afghanistan.
11
Pei, Jiantao, and n/a. "The Accuracy of Time-to-Contact Estimation in the Prediction Motion Paradigm." University of Canberra. Applied Science, 2002. http://erl.canberra.edu.au./public/adt-AUC20050627.143329.
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This thesis is concerned with the accuracy of our estimation of time to make contact
with an approaching object as measured by the “Prediction Motion” (PM) technique.
The PM task has commonly been used to measure the ability to judge time to contact
(TTC). In a PM task, the observer's view of the target is occluded for some period
leading up to the moment of impact. The length of the occlusion period is varied and
the observer signals the moment of impact by pressing a response key. The interval
separating the moment of occlusion and the response is interpreted as the observer's
estimate of TTC made at the moment of occlusion. This technique commonly
produces large variability and systematic underestimation. The possibility that this
reflects genuine perceptual errors has been discounted by most writers, since this
seems inconsistent with the accuracy of interceptive actions in real life. Instead, the
poor performance in the PM task has been attributed to problems with the PM
technique. Several hypotheses have been proposed to explain the poor PM
performance. The motion extrapolation hypothesis asserts that some form of mental
representation of the occluded part of the trajectory is used to time the PM response;
the errors in PM performance are attributed to errors in reconstructing the target
motion. The clocking hypothesis assumes that the TTC is accurately perceived at the
moment of occlusion and that errors arise in delaying the response for the required
period. The fear-of-collision hypothesis proposes that the underestimation seen in
the PM tasks reflects a precautionary tendency to anticipate the estimated moment of
contact. This thesis explores the causes of the errors in PM measurements.
Experiments 1 and 2 assessed the PM performance using a range of motion scenarios
involving various patterns of movement of the target, the observer, or both. The
possible contribution of clocking errors to the PM performance was assessed by a
novel procedure designed to measure errors in the wait-and-respond component of
the PM procedure. In both experiments, this procedure yielded a pattern of
systematic underestimation and high variability similar to that in the TTC estimation
task. Experiment 1 found a small effect of motion scenario on TTC estimation.
However, this was not evident in Experiment 2.
The collision event simulated in Experiment 2 did not involve a solid collision. The
target was simply a rectangular frame marked on a tunnel wall. At the moment of
“contact”, the observers passed “through” the target without collision. However,
there was still systematic underestimation of TTC and there was little difference
between the estimates obtained in Experiments 1 and 2. Overall, the results of
Experiments 1 and 2 were seen as inconsistent with either the motion extrapolation
hypothesis or the fear-of-collision hypothesis. It was concluded that observers
extracted an estimate of the TTC based on optic TTC information at a point prior to
the moment of collision, and used a timing process to count down to the moment of
response. The PM errors were attributed to failure in this timing process. The results
of these experiments were seen as implying an accurate perception of TTC.
It was considered possible that in Experiments 1 and 2 observers based their TTC
judgements on either the retinal size or the expansion rate of the target rather than
TTC. Experiments 3 and 4 therefore investigated estimation of TTC using a range of
simulated target velocities and sizes. TTC estimates were unaffected by the resulting
variation in expansion rate and size, indicating that TTC, rather than retinal size or
image expansion rate per se, was used to time the observers' response.
The accurate TTC estimation found in Experiments 1-4 indicates that the TTC
processing is very robust across a range of stimulus conditions. Experiment 5 further
explored this robustness by requiring estimation of TTC with an approaching target
which rotated in the frontoparallel plane. It was shown that moderate but not fast
rates of target rotation induced an overestimation of TTC. However, observers were
able to discriminate between TTCs for all rates of rotation. This shows that the
extraction of TTC information is sensitive to perturbation of the local motion of the
target border, but it implies that, in spite of these perturbations, the mechanism is
flexible enough to pick up the optic TTC information provided by the looming of the
retinal motion envelop of the rotating stimulus.
12
Zhang, Yu. "Mechanisms of chromosomal instability induced by unstable DNA repeats in yeast S.cerevisiae." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52185.
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DNA repetitive sequences capable of adopting non-B DNA structures are a potent source of instability in eukaryotic genomes. They are strong inducers of chromosomal fragility and genome rearrangements that cause various hereditary diseases and cancers. In addition, a subset of repeats also has an ability to expand, which leads to more than 20 human genetic diseases that are collectively known as repeat expansion diseases. However, the mechanisms underlying the potential of these structure-prone motifs to break and expand are largely unknown.
In this study, a systematic genome-wide screen was employed in yeast Saccharomyces cerevisiae to investigate the contributing factors of the instability of two representative non-B DNA-forming repeats: the triplex-adopting GAA/TTC tracts and the inverted repeats that can form hairpin and cruciform structures.
The GAA/TTC screen revealed that DNA replication and transcription initiation are the two major pathways governing the GAA/TTC stability in yeast, as corresponding mutants strongly induce both fragility and large-scale expansions of the repeats. The inverted repeats screen and follow-up experiments revealed that both replication-dependent and -independent pathways are involved in maintaining the stability of palindromic sequences.
We propose that similar mechanisms could operate in the human cells to mediate the deleterious metabolism of GAA and inverted repeats.
13
Morato, Tiago Nóbrega. "Avaliação da dinâmica normal da circulação do meio de contraste em estruturas vasculares nos exames de tomografia computadorizada das artérias coronárias." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.D.18431.
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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2015.<br>Submitted by Cristiane Mendes (mcristianem@gmail.com) on 2015-07-07T19:15:02Z
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2015_TiagoNobregaMorato.pdf: 275774 bytes, checksum: 53d29410be3596461f972180faf17305 (MD5)<br>Introdução: O uso de agentes de contraste intravenoso é corriqueiro em pacientes submetidos à tomografia computadorizada (TC) de tórax. Sabe-se que o tempo de trânsito de contraste (TTC) do sítio de injeção até a circulação sistêmica tem relação com o débito cardíaco e pode trazer importantes informações funcionais, pouco estudadas até o momento. Objetivos: Medir o TTC entre o tronco pulmonar e aorta ascendente em exames de TC de artérias coronárias de pacientes saudáveis, definindo padrões de normalidade para estes tempos de circulação. Métodos: Pacientes ambulatoriais sadios encaminhados para realização de TC de artérias coronárias arrolados de forma consecutiva. Os TTC entre o sítio de injeção e a veia cava superior, tronco pulmonar e aorta ascendente foram medidos com base nas imagens de monitorização (bolus tracking). O débito cardíaco foi calculado a partir das imagens da TC pelo método geométrico e correlacionado com os TTC. Resultados: Foram analisados 18 pacientes. O TTC médio entre a artéria pulmonar e a aorta ascendente foi de 6,8 ± 1,6s. Não houve correlação significativa entre o TTC na circulação pulmonar e o débito cardíaco medido pelo método geométrico. Conclusão: O valor de normalidade do TTC entre a artéria pulmonar e aorta ascendente foi estabelecido, servindo de base para avaliação clínica.<br>Introduction: The use of contrast agents is a common radiological practice in chest tomography (CT) examinations. It’s known that the transit time of the contrast agent (TTC) between the injection site and the systemic circulation is related to the cardiac output and can add important functional information. Nevertheless, there is little information regarding the normal transit times. Objectives: Measure the TTC between main pulmonary artery and ascending aorta in coronary artery CT’s of healthy patients, defining the normality values for such circulatory times. Methods: Healthy ambulatorial patients who underwent coronary artery CT were included. The TTC’s between the injection site and inferior vena cava, main pulmonary artery and ascending aorta were measured using the bolus tracking images. The cardiac output was measured from the CT images using the geometric method. Results: 18 patients were included in the analysis. The mean TTC between the mean pulmonary artery and aorta was 6,8 ± 1,6s. There was no significant correlation between the TTC and cardiac output measured by the geometric method. Conclusion: The normal value for the TTC between main pulmonary artery and ascending aorta was determined, and can be used as a reference for future publications.
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Ahlqvist, Sigge, and Matteus Arriaza-Hult. "How to measure the degree of PIT-ness in a credit rating system for a low default portfolio?" Thesis, KTH, Matematisk statistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273632.
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In order to be compliant with the Basel regulations, banks need to compute two probabilities of default (PDs): point-in-time (PIT) and through-the-cycle (TTC). The aim is to explain fluctuations in the rating system, which are expected to be affected by systematic and idiosyncratic factors. Being able to, in an objective manner, determine whether the rating system is taking the business cycle - i.e the systematic factors - into account when assigning a credit rating to an obligor is useful in order to evaluate PD-models. It is also necessary for banks in order to use their own risk parameters and models instead of standardized models, which is desirable for most banks as it could lower capital requirements. This thesis propose a new measure for the degree of PIT-ness. This measure aims to be especially useful when examining a low default portfolio. The proposed measure is built on a markovian approach of the credit rating system. In order to find a suitable measure for a low default portfolio, the proposed measure takes into account credit rating migrations, the seasonal component of the business cycle and time series analysis. An analysis were performed between two different credit portfolios in order to interpret results. The results demonstrated that the degree of PIT-ness was lower in a low default portfolio in comparison with a sampled portfolio which displayed a greater amount of rating migrations with a larger magnitude. The importance of considering relevant macroeconomic variables to represent the business cycle was mentioned amongst the most important factors to consider in order to receive reliable results given the proposed measure.<br>För att uppfylla Basel regelverken behöver banker beräkna två sannolikheter för fallissemang (PD): point-in-time (PIT) och through-the-cycle (TTC). Målet är att förklara fluktuationer i betygssystemet, som förväntas påverkas av systematiska och idiosynkratiska faktorer. Att på ett objektivt sätt kunna avgöra om betygssystemet tar hänsyn till affärscykeln - dvs de systematiska faktorerna - när man tilldelar en kredittagare ett kreditbetyg är användbart för att utvärdera PD-modeller. Detta är också nödvändigt för att banker ska få använda sina egna riskparametrar och modeller istället för standardiserade modeller, vilket är önskvärt för de flesta banker eftersom det kan sänka kapitalkraven. Denna avhandling föreslår ett nytt mått för att mäta graden av PIT-ness. Detta mått syftar till att vara särskilt användbart när man utvärderar en kreditportfölj med få fallissemang. Det föreslagna måttet är byggt på en Markov tillämpning på kreditbetygssystemet. För att hitta ett lämpligt mått för en kreditportfölj med få fallissemang, tar det föreslagna måttet hänsyn till kreditbetygsmigrationer, säsongskomponenten i affärscykeln och tidsserieanalys. En analys utfördes mellan två olika kreditportföljer för att tolka resultaten. Resultaten visade att graden av PIT-ness var lägre i en kreditportfölj med få fallissemang jämfört med en testportfölj som uppvisade en större mängd kreditbetygsmigrationer med en större magnitud. Vikten av att beakta relevanta makroekonomiska variabler för att representera affärscykeln nämndes bland de viktigaste faktorerna att beakta för att få tillförlitliga resultat givet det föreslagna måttet.
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Kim, Hyun-Min. "Genome instability induced by triplex forming mirror repeats in S.cerevisiae." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/33874.
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The main goal of this research is to understand molecular mechanisms of GAA/TTC-associated genetic instability in a model eukaryotic organism, S. cerevisiae. We demonstrate that expanded GAA/TTC repeats represent a threat to eukaryotic genome integrity by triggering double-strand breaks and gross chromosomal rearrangements. The fragility potential strongly depends on the length of the tracts and orientation of the repeats relative to the replication origin and to block replication fork progression. MutSbeta complex and endonuclease activity of MutLalpha play an important role in facilitation of fragility. In addition to GAA/TTC triplex forming repeats, non-GAA polypurine polypyrimidine mirror repeats that are prone to the formation of similar structures were found to be hotspots for rearrangements in humans and other model organisms. These include H-DNA forming sequences located in the major breakpoint cluster region at BCL2, intron 21 of PKD1, and promoter region of C-MYC. Lastly, we have investigated the effect of the triplex-binding small molecules, azacyanines, on GAA-mediated fragility using the chromosomal arm loss assay. We have found that in vivo, azacyanines stimulate (GAA/TTC)-mediated arm loss in a dose dependent manner in actively dividing cells. Azacyanines treatment enhances the GAA-induced replication arrest. We discovered that also, azacyanines at concentrations that induce fragility also inhibit cell growth. Over 60% of yeast cells are arrested at G2/M stage of the cell cycle. This implies an activation of DNA-damage checkpoint response.
16
Saini, Natalie. "Understanding the mechanisms underlying DSB repair-induced mutagenesis at distant loci in yeast." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51843.
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Increased mutagenesis is a hallmark of cancers. On the other hand, this can trigger the generation of polymorphisms and lead to evolution. Lately, it has become clear that one of the major sources of increased mutation rates in the genome is chromosomal break formation and repair.
A variety of factors can contribute to the generation of breaks in the genome. A paradoxical source of breaks is the sequence composition of the genomic DNA itself. Eukaryotic and prokaryotic genomes contain sequence motifs capable of adopting secondary structures often found to be potent inducers of double strand breaks culminating into rearrangements. These regions are therefore termed fragile sequence motifs. Here, we demonstrate that in addition to being responsible for triggering chromosomal rearrangements, inverted repeats and GAA/TTC repeats are also potent sources of mutagenesis. Repeat-induced mutagenesis extends up to 8 kb on either side of the break point. Remarkably, error-prone repair of the break by Polζ reconstitutes the repeats making them a long term source of mutagenesis.
Despite its negative connotations for genome stability, the mechanisms underlying the unstable nature of double strand break repair pathways are not known. Previous studies have demonstrated that break induced replication (BIR), a mechanism employed to repair broken chromosomes with only one repairable end, is highly mutagenic, undergoes frequent template switching and often yields half-crossovers. In the work presented here, we show that the instabilities inherent to BIR can be attributed to its unusual mode of synthesis. We determined that BIR proceeds via a migrating bubble with long stretches of single-stranded DNA and culminates with conservative inheritance of the newly synthesized DNA.
We propose that the mechanisms described here might be important for generation of repair-associated mutagenesis in higher organisms. Secondary structure forming repeats like inverted repeats have been found to be enriched in cancer cells. These motifs often constitute chromosomal rearrangement hot-spots and demonstrate the phenomenon of kataegis. This study provides a mechanistic insight into how such breakage-prone motifs contribute to hypermutability of cancer genomes.
17
Barona, Marco Antonio Acevedo. "Epistasia e interação epistasia por locais para a produção de grãos em soja." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-20032008-173225/.
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Nos programas de melhoramentos de soja as progênies endogâmicas são frequentemente avaliadas como possíveis cultivares. O estudo da estrutura da variação genética entre progênies de diferentes gerações de autofecundação depende da ação dos locos envolvidos e da variação do caráter sob estudo. Em soja o caráter produção de grãos (PG) é considerado o de maior importância econômica e destaca-se por apresentar herança quantitativa e ser altamente influenciada pelo ambiente. As estratégias de seleção utilizadas para o desenvolvimento de cultivares em soja poderiam ser otimizadas através do estudo da importância relativa dos componentes de variância, particularmente a proporção de variação devida à interação não alélica (epistasia). Com o objetivo de estudar a variação epistática e sua interação com ambientes (locais) para a produção de grãos em soja utilizou-se o delineamento "Triple Test Cross Modificado" (TTC) de JINKS, PERKINS e BREESE (1969). Uma amostra de 32 linhagens (Pi) derivadas de um cruzamento biparental foi cruzada com duas linhagens divergentes (L1 e L2) contrastantes para PG, derivadas da mesma população (testadores). Os experimentos de avaliação foram conduzidos no ano agrícola de 2006/2007 em dois locais (Piraciacaba e Anhembi) em delineamentos em látice triplo 10 x 10. Os tratamentos correspondiam aos 32 cruzamentos Pi x L1, 32 cruzamentos Pi x L2, 34 linhas puras (32 Pi + 2 testadores) e duas testemunhas comerciais. De acordo com a metodologia utilizada foram estudados os contrastes ( i 2i 1i P L L - + ) para avaliar a ocorrência de epistasia. Os resultados das análises individuais mostraram que a epistasia afetou a expressão da produção de grãos em ambos os locais. A análise conjunta permitiu detectar significância para locais, epistasia e interação epistasia por locais, indicando que a produção de grãos em soja é afetada pela interação não alélica (epistasia) e que esta não é consistente entre locais. O estudo do contraste ( i 2i 1i P L L - + ) das médias individuais nas análises por local e na análise conjunta indicou haver contribuição diferencial dos genótipos para a epistasia. Os resultados gerais indicam que a epistasia pode ser um componente importante para a expressão da produção de grãos de soja e, consequentemente, esta deveria ser incluída nos modelos para a decomposição dos componentes da variância genética.<br>In soybean breeding programs the selfing progenies are generally evaluated as possible cultivars. The study of the structure of the genetic variation among progenies in different generations of selfing depends upon the action of the loci involved and the variability of the trait under study. In soybeans, grain yield is the most important trait and it is characterized by a quantitative inheritance and highly influenced by the environment. The selection strategies used for the development of soybean cultivars could be optimized through the study of the relative importance of the variance components, in particular the proportion of the non-allelic interaction component (epistasis). In order to study the epistatic variation and its interaction with locations for grain yield in soybeans the "Modified Triple Test Cross" (TTC) method (JINKS, PERKINS e BREESE, 1969) was used. A sample of 32 inbred lines (Pi) derived from a single cross were crossed with two divergent inbred lines (L1 e L2) of the same population (testers). The experiments were carried out in the 2006/2007 growing season in two locations (Piracicaba and Anhembi) in a 10x10 triple lattice design. Entries consisted of the 32 Pi x L1 crosses, 32 Pi x L2 crosses, 34 lines (Pi + 2 testers) and 2 commercial checks. Following the methodology, the contrasts ( i 2i 1i P L L - + ) were studied in order to evaluate the occurrence of epistasis. General results showed that epistasis affected grain yield in soybeans in both locations. Significance for locations, epistasis and epistais by locations interactions were also detected in the joint analysis of variance, indicating that grain yield in soybeans is affected by the non-allelic interaction (epistasis) and that the epistasis is not consistent in different locations. A study of the contrast ( i 2i 1i P L L - + ) of individual means for each location and in the joint analyses indicated the occurrence of differential contribution of the genotypes for the epistasis. General results had demonstrated that epistasis could be an important component for the expression of grain yield in soybeans and consequently it should be included in the model for the partition of the genetic components of variance.
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Zhang, Chi. "Tic-tac-toe game design based on Xilinx FPGA." Thesis, Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-6135.
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This design accomplished Tic-Tac-Toe game on Xilinx Spartan-IIE FPGA platformin VHDL. Firstly, designing the circuits and wiring on experiment board. Secondly,designing the algorithm and programming it in Active-HDL. Thirdly, synthesizingit in Synplicity Synplify Pro and then implementing it in Xilinx ISE developingsuite. Finally download it onto FPGA to run it. This design allows two players to play Tic-Tac-Toe game on the experiment board.Pressing the key, the corresponding LED will be light up to represent thechessman. There are two LEDs indicate whose turn next is. If the grid one wantsto place chessman has been taken up, then LCD will alarm it and ask the playerto replace it. The first player who forms 3 chessmen in a row, column or diagonalwins, LCD will display it and the three LEDs in the winning line will blink. If nobody wins after filling the whole chessboard, then LCD displays draw.
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Lennon, Todd L. "Object oriented design of Tactical Tic-Tac-Toe C4I simulation." Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1996. http://handle.dtic.mil/100.2/ADA313558.
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Thesis (M.S. in Systems Technology (Command, Control and Communications)) Naval Postgraduate School, June 1996.<br>"June 1996." Thesis advisor(s): Gary R. Porter,Michael G. Sovereign. Bibliography: p. 85. Also Available online.
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Tandazo, Balladares Elmer. "Las TIC TAC y su influencia en la práctica pedagógica." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2018. http://tesis.pucp.edu.pe/repositorio/handle/123456789/10578.
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Al realizar el análisis de los resultados de los aprendizajes de los estudiantes de los tres últimos años se observó que no están logrando los aprendizajes esperados como también deserción y repitencia del año escolar por tal razón el presente Plan de Acción está elaborado con la intención de fortalecer las capacidades docentes en estrategias didácticas y metodológicas del enfoque por competencias mediante talleres de actualización de las TIC TAC para desarrollar sesiones de aprendizaje más interactivas, entretenidas, motivadoras y significativas y así elevar el porcentaje de estudiantes en el nivel de satisfactorio de los aprendizajes ya que la mayoría de nuestros estudiantes se ubican nivel de inicio, según Mónica Moya López incorporación de las TIC TAC en las sesiones de aprendizaje favorecen al modelo TPACK donde fomenta el desarrollo de la competencia digital en los estudiantes siendo un tema transversal en currículo nacional de educación básica basado en un enfoque socio-constructivista, Roser Lozano plantea que se debe cambiar el aprendizaje de la tecnología por el aprendizaje con la tecnología, enfoque que está orientado al desarrollo de competencias fundamentales como el aprender a aprender, al aplicar este plan de acción en la institución educativa, nuestros estudiantes desarrollaran sus aprendizajes basado en un paradigma por competencia enfocado en potenciar sus capacidades cognitivas, socio emocionales y digitales que el mundo actual lo requiere.<br>Trabajo académico
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Villasevil, Marco F. Xavier (Francesc Xavier). "Influencia de los multimedia (TIC-TAC) en el proceso enseñanza/aprendizaje." Doctoral thesis, Universitat Politècnica de Catalunya, 2016. http://hdl.handle.net/10803/385747.
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There is a gap between the potential of ICT incorporated into classrooms and limited renewal of the educational process and thechnology is nothing without pedagogical innovation. ICT/TAC have been incorporated in our univers ities, often associated with little participatory policies and teaching practices. For example, in many cases they have simply replaced the traditional blackboards for Power Point presentations and the queues in reprographics have disappeared, "hanging" files on Campus.
This problem leads us to conclude that neither at the beginning of this investigation, nor now, it doesen't exist, for the training of the future engineers, a docent methodology equal to the proposed that have been applied and evaluated successfully in its aplication; and in this research it has also elaborated, implemented and evaluated multimedia tools "ad hoc"; although we do observe essays with proposals that collect partial and isolated aspects of it.
In a synthetic way, this is precisely what gives this present Thesis: A tool multimedia designed specifically to apply with a methodology that links with the premises of new European Higher Education Area; and further proposes a real change in the mentalities and docent structures of the technical education, avoiding any temptation of "cosmetic" changes.
A methodology wiht a multimedia that pivot on the learning, on the training on skills, abilities and dexterity; it means, a balanced training that provides an adequate personal competence, oriented to the employability and to the knowledge generation. It is therefore we have proposed and achieved the following objectives:
* Develop a multimedia supported by a methodological system to allow the students achieve metacognitive levels that facilitate the labor marked access and let them evolve quickly toward an expert engineer levels.
* Determine the influence that has the "ad hoc" multimedia applied to the methodological process proposed about the conceptual and procedural learning.
* Apply and check the influence of both the model and the multimedia in engineering studies about the meta-cognitive development and in the autonomy or self-regulatory capacity of the student.
* Investigate the student attitudinal change by appliying multimedia "ad hoc".
* Promote the meta-knowledge of students of Engineering.
Provide solutions to the current problems in the formation of the future Engineer, in the social and technological context.
Strengthen the type of skills needed to develop successful professional work related to desingn and diagnosi.<br>Existe un desfase entre la potencialidad de las TIC incorporadas a las aulas y la escasa renovación del proceso pedagógico, y la tecnología no es nada sin la innovación pedagógica. Las TIC/TAC se han ido incorporando en nuestras universidades, a menudo asociadas a prácticas docentes directivas y poco participativas. Por ejemplo, en muchos casos simplemente se han sustituido las tradicionales pizarras por presentaciones "Power Point" y han desaparecido las colas en reprografía, "colgando" los archivos en el Campus. Esta problemática nos lleva a concluir que ni al inicio de la presente investigación, ni en la actualidad, existe de manera generalizada en la formación de los futuros Ingenieros una metodología docente de características iguales a la planteada y que haya sido aplicada y evaluada con éxito en su aplicación; y en la presente investigación además se han elaborado, aplicado y evaluado herramientas multimedia "ad hoc"; aunque si vamos observando ensayos con propues tas que recogen aspectos parciales y aislados de la misma. Dicho de manera sintética, esto es lo que aporta precisamente la presente Tesis: Unos multimedia diseñados específicamente para aplicar junto a la metodología que enlaza con las premisas del nuevo Espacio Europeo de Educación Superior; y que además propone un cambio real en las mentalidades y estructuras docentes de las enseñanzas técnicas, evitando cualquier tentación de cambios cosméticos. Una metodología con unos multimedia que pivotan sobre el aprendizaje, sobre la formación en competencias, capacidades y destrezas; es decir, una formación equilibrada que proporcione una competencia personal suficiente, orientada a la empleabilidad y a la generación de conocimiento. Es por ello que se han planteado y conseguido los siguientes objetivos: * Elaborar unos multimedia apoyados en un sistema metodológico destinado a conseguir que los alumnos alcancen unos niveles meta cognitivos que le faciliten la salida al mundo laboral y le permitan evolucionar en poco tiempo hacia los niveles de un Ingeniero experto. *Determinar la influencia que los multimedia "ad hoc" aplicados al proceso metodológico propuesto tienen sobre el aprendizaje conceptual y procedimental. *Aplicar y comprobar la influencia que ejercen tanto el modelo como los multimedia propios, en los estudios de Ingeniería, sobre el desarrollo meta-cognitivo y en la autonomía o capacidad de autorregulación del alumno. * Investigar el cambio actitudinal del estudiante al aplicar los multimedia "ad hoc". * Potenciar el meta-conocimiento de los alumnos de Ingeniería. *Aportar soluciones a la problemática actual en la formación del futuro Ingeniero, en el contexto social y tecnológico. * Potenciar el tipo de habilidades que se requieren para desarrollar con éxito los trabajos profesionales relacionados con diseño y diagnóstico
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Hayes, Julie Anne. "TAC-TIC : a non-pharmacological approach to the alleviation of neonatal pain." Thesis, University of Wolverhampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339912.
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Intensive care IS a stressful environment and this thesis addresses the controversy as to whether tactile stimulation can mitigate the negative influences in ventilated preterms. There is an underlying assumption throughout the thesis that the pre term infant in intensive care experiences and is able to manifest physical and/or psychological pain. Preterms (n=75) were recruited with parental consent against strict entry criteria. A pre-test, post-test time series, counterbalanced design was used to evaluate the impact of an intervention to alleviate pain. The intervention [Touching and Caressing, Tender in Caring (T AC-TIC)] was compared with a control condition (spontaneous activity). Indicators of pain represented in the experiments were immunologic, physiological, and neurobehavioural. Data were analysed using parametric and non-parametric tests. The ontogeny of the secretory Immune system was investigated (n=70) using an enzyme-linked immunosorbant assay for Secretory Immunoglobulin A (SIgA). Ventilated preterms had significantly lower SIgA than infants requiring no mechanical ventilation. Breast milk fed preterms showed increased SIgA compared to other modes of nutrition. TACTIC increased SIgA in a subsample of ventilated preterms (n=35) with no changes following the control condition. Cardiovascular responses remained stable throughout T AC-TIC and spontaneous activity. No changes in gastric pH were observed in a sub-sample of 18 preterms. A neurobehavioural checklist was used to analyse videos for pain and comfort behaviours (n=29). Significantly more comfort behaviours were reported during T AC-TIC. Analysis of behavioural state indicated that more time was spent inactive sleep during than after TAC-TIC. No differences In state occurred between TAC-TIC and control condition. A ventilated subsample (n=25) of the original cohort was subjected to analysis at individual level for determination of congruence between simultaneously measured outcome variables. T AC-TIC produced increases more often in two or three variables. Pilot work has also been conducted addressing further controversies in tactile stimulation. The results are discussed within the theoretical frameworks of Gottlieb's hierarchical systems model, and Adamson-Macedo's Equilibrium model
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Richardson, Jeffrey S. "Comparison of information delay types and levels in Tactical Tic-Tac-Toe (T4)." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA267407.
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Thesis (M.S. in Systems Technology)--Naval Postgraduate School, March 1993.<br>Thesis advisor(s): Sovereign, Michael G. ; Porter, Gary R. "March 1993." Includes bibliographical references. Also available online.
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Norris, Lisa A. "Modeling C3 : the effects of information delay in Tactical Tic-Tac-Toe (T4)." Thesis, Monterey, California. Naval Postgraduate School, 1992. http://hdl.handle.net/10945/23964.
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Zarrillo, Eugene M. "A systems evaluation approach to analysis of Tactical Tic-Tac-Toe (T4) generated data." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA271746.
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Thesis (M.S. in Systems Technology) Naval Postgraduate School, June 1993.<br>Thesis advisor(s): Michael G. Sovereign ; Gary R. Porter. "June 1993." Includes bibliographical references. Also available online.
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Duvvuri, Sri Rama Bhaskara Kumari. "Driver Safety and Emissions at Different PPLT Indications." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/75236.
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According to NCHRP Report 493, there are five major left turn signal indications for permitted operations in the United States. They are: Circular Green (CG), Flashing Circular Red (FCR), Flashing Red Arrow (FRA), Flashing Circular Yellow (FCY) and Flashing Yellow Arrow (FYA). The main goal of this thesis is to study the driver behavior and analyze safety of drivers for different left turn indications using a real-time driving simulator. Different signal indications alter driver behavior which influences velocity and acceleration profiles. These profiles influence vehicular emissions and hence need to be studied as well. For this purpose, different scenarios are implemented in the driving simulator. Data is analyzed using Microsoft Excel, JMP Statistical tool and MATLAB. Safety of drivers is analyzed with respect to the parameter "Time to Collision (TTC)" which is directly obtained from simulator data. Vehicular emissions and fuel consumption are calculated using VT-Micro microscopic emissions model. Graphs are plotted for TTC and total emissions. Results indicate that for a day-time scenario, FCY and FYA are the most suitable left-turning indications whereas FCR and FRA are most suitable for a night-time scenario.<br>Master of Science
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Nègre, Amaury. "Evitement d'obstacles par invariants visuels." Phd thesis, Grenoble INPG, 2009. http://www.theses.fr/2009INPG0016.
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Dans un contexte de navigation visuelle en environnement ouvert et dynamique, la détection d'obstacles constitue un élément indispensable. Dans cette thèse, nous nous intéressons à la caractérisation des obstacles par le temps avant collision (TTC). Ayant montré que ce TTC peut être calculé directement dans une image à l'aide de l'échelle intrinsèque, nous avons mis au point un détecteur ainsi qu'un algorithme de suivi invariant au changement d'échelle et adapté à un environnement urbain. Ce détecteur permet d'extraire des régions d'intérêt appelées segments de crête correspondant à des formes contrastées et rectilignes dans l'image. Le suivi de ces régions d'intérêt est fondé sur un filtre à particules et permet de mesurer la variation d'échelles afin d'estimer le TTC. Enfin, nous avons étudié deux applications de navigation visuelle d'un véhicule telles que l'arrêt du véhicule avant collision et un système d'évitement réactif d'obstacles bayésien<br>In the context of visual navigation in an open and dynamic environment, obstacle detection play a major role. In this thesis, we are interested in the characterization of obstacles by the Time To Collision (TTC). We showed that this TTC can be computed directly in an image by using the characteristic scale. Next, we developed a detector and a tracker invariant to change of scale and well adapted to urban environments. This detector can extract regions of interest called “ridge segments” corresponding to contrasted and elongated shapes in the image. The tracking of such structures is based on a particles filter and allows the calculation of the scale in order to estimate the TTC. At last, we studied two applications for visual navigation such as automatic stopping of vehicle and a Bayesian reactive obstacles avoidance system
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Nègre, Amaury. "Evitement d'obstacles par invariants visuels." Phd thesis, Grenoble INPG, 2009. http://tel.archives-ouvertes.fr/tel-00371261.
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Dans un contexte de navigation visuelle en environnement ouvert et dynamique, la détection d'obstacles constitue un élément indispensable. Dans cette thèse, nous nous intéressons à la caractérisation des obstacles par le temps avant collision (TTC). Ayant montré que ce TTC peut être calculé directement dans une image à l'aide de l'échelle intrinsèque, nous avons mis au point un détecteur ainsi qu'un algorithme de suivi invariant au changement d'échelle et adapté à un environnement urbain. Ce détecteur permet d'extraire des régions d'intérêt appelées segments de crête correspondant à des formes contrastées et rectilignes dans l'image. Le suivi de ces régions d'intérêt est fondé sur un filtre à particules et permet de mesurer la variation d'échelles afin d'estimer le TTC. Enfin, nous avons étudié deux applications de navigation visuelle d'un véhicule telles que l'arrêt du véhicule avant collision et un système d'évitement réactif d'obstacles bayésien.
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Tonello, Karolina Pereira dos Santos. "Compósitos de alumina com adições de NbC, TaC e TiC para aplicação em ferramentas de corte." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-29052013-092205/.
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No presente trabalho foram desenvolvidos compósitos à base de alumina, com adição de carbetos de metais de transição, NbC, TaC e TiC, como reforço. Os carbetos, na forma de partículas, foram adicionados em 1,5% em volume à matriz de alumina durante a moagem em attritor. O processamento foi realizado por moagem em attritor, secagem em rotoevaporadora e desaglomeração em peneira. A dinâmica de oxidação dos carbetos e das composições dos compósitos foi estudada para a definição de parâmetros de sinterização e processamento dos compósitos. A cinética de sinterização foi estudada por dilatometria, com taxa de 10°C/min. até 1600°C em atmosfera de ar sintético, e até 1800°C, em atmosfera de argônio, com esta etapa foi possível verificar que o NbC e o TiC dificultaram a sinterização da alumina e que o TaC auxiliou nos processos de retração. Nas amostras que foram sinterizadas em dilatômetro ao ar foram detectadas fases resultantes de fusão congruente nos compósitos Al2O3/NbC e Al2O3/TaC, foram também observadas evidências de formação de líquido no compósito com adição de TaC. Com base nesses resultados foram estudadas duas técnicas de produção das ferramentas de corte: prensagem uniaxial seguida de sinterização sem pressão e sinterização por prensagem a quente. Todas as amostras foram caracterizadas microestruturalmente e quanto às propriedades mecânicas, tendo-se determinado que as amostras produzidas por prensagem a quente possuem microestrutura mais controlada e propriedades mecânicas superiores às produzidas por sinterização sem pressão. Pelos processos estudados foi observado que os carbetos influenciam diferentemente a sinterização da alumina. De maneira geral a presença destas fases nos contornos de grãos promove alterações na microestrutura modificando o tamanho de grãos da alumina. Foi proposta a hipótese de que esse comportamento é afetado pela formação de uma camada superficial resultante da oxidação dos reforços, com isto, de acordo com os diagramas de fase é possível a formação de soluções sólidas entre alumina e Ta2O5 e Nb2O5 além da formação de fase líquida, estes mecanismos alterariam a mobilidade dos contornos de grão da alumina. Para o processamento das ferramentas de corte foi utilizada prensagem a quente, escolhido pelo critério da microestrutura e propriedades mecânicas. Os testes de usinagem foram realizados com ferramentas de corte de geometria quadrada, em peças de ferro fundido cinzento e vermicular. O tempo de vida útil da ferramenta produzida com o compósito Al2O3/ NbC foi 13% superior quando comparado à uma ferramenta cerâmica comercial no teste de usinagem de ferro fundido cinzento.<br>In the present work alumina based composites with addition of transition metal carbides, NbC, TaC and TiC as reinforcement phase were developed. The carbides, in particulate form, were added in 1.5vol.% on the alumina matrix during attritor milling. The processing was conducted by attritor milling, drying in a rotoevaporator and deagglomeration in sieve. The oxidation dynamics of carbides and composities were studied in order to define the sintering and processing parameter of composites. The sintering kinetics was studied by dilatometry at 10° C/min. up to 1600 ° C in synthetic air atmosphere and up to 1800°C in argon, with this step it was possible to verify that the NbC and TiC hindered the sintering of alumina and the TaC helped in the retraction process. In the sintered by dilatometer in air phases resultant from congruent melting on Al2O3/NbC and Al2O3/TaC composites were detected in the composite with TaC addition was also observed evidence of liquid phase. In the samples sintered in dilatometer in air were detected solid solutions on composites CN and CTa and evidence of liquid formation in the composite with TaC addition. Based on these results two techniques were studied in order to produce cutting tools: uniaxial pressing, followed by pressureless sintering and hot pressing. All samples were characterized by microstructure and mechanical properties, and it was shown that samples produced by hot pressing have more controlled microstructure and mechanical properties superior to those produced by pressureless sintering. With the studied processes it was observed that the carbides influence differently alumina sintering. Generally the presence of these phases at the grain boundary causes changes in the microstructure modifying alumina grain size alumina. The proposed hypothesis is that this behavior would be affected by the formation of a surface layer resulting from oxidation of reinforcements with that, according to the phase diagrams, it is possible to find solid solutions between alumina and Ta2O5 and Nb2O5 and possible formation of liquid phase, which alter the mobility of the grain boundary of alumina. Hot pressing was used for the processing of cutting tools, chosen due to the microstructure and mechanical properties. The machining tests were performed with square geometry cutting tools, in samples of gray cast iron and compacted graphite iron. The tool life of cutting tool produced with Al2O3 / NbC composite was 13% higher when compared to a commercial ceramic cutting tool on machining of gray cast iron.
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TONELLO, KAROLINA P. dos S. "Compósitos de alumina com adições de NbC, TaC e TiC para aplicação em ferramentas de corte." reponame:Repositório Institucional do IPEN, 2013. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10206.
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Made available in DSpace on 2014-10-09T12:36:00Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:59:33Z (GMT). No. of bitstreams: 0<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Söderstedt, Hanna. "Filmrecensioner ur ett genusperspektiv : En receptionsanalys av Drömprinsen-filmen om Em, Tic tac, Patrik 1,5 och Varg." Thesis, Växjö University, School of Humanities, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-2558.
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<p>Denna uppsats analyserar filmrecensioner skrivna om två filmer av Ella Lemhagen och två filmer av Daniel Alfredson. Recensionerna är lästa ur ett genusperspektiv för att undersöka om recensentens sätt att skriva avsöljar om regissören är en man eller en kvinna, och i så fall hur detta kan se ut.</p>
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Pelletier, Aurore. "Fonctions des peptides smORF Tic-Tac et Sem1 dans la reproduction et le développement chez la Drosophile." Electronic Thesis or Diss., Toulouse 3, 2023. http://www.theses.fr/2023TOU30269.
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De récentes avancées technologiques ont révélé que des petits ORF (Open Reading Frame), dont la taille est inférieure à 100 codons et qui étaient jusqu'à présent considérés comme non codants à cause de leur petite taille, peuvent être traduits en des milliers de petits peptides smORF (small ORF) dans tous les organismes. Plusieurs études ont montré que des peptides smORF peuvent interagir avec des protéines canoniques et réguler leur activité. La famille des peptides smORF représente ainsi un réservoir largement inexploré de potentiels régulateurs. Un crible fonctionnel mené chez la Drosophile nous a permis d'identifier de nouveaux peptides smORF impliqués dans le développement, dont plusieurs sont issus de la traduction d'ARN polycistroniques. Mon projet de recherche de thèse a été de caractériser la fonction chez la Drosophile de 1) Tic et Tac, deux peptides smORF inconnus codés par un ARN bicistronique , et de 2) Sem1/DSS1, un peptide très conservé. La première partie de mes travaux de thèse a été d'analyser la fonction biologique de deux peptides smORF inconnus codés par un ARN bicistronique que nous avons nommé tictac. J'ai démontré que Tic et Tac sont deux peptides traduits à partir du même ARN bicistronique tictac, dont la séquence en AA et la localisation cellulaire sont différentes. In vivo, tictac est fortement exprimé dans les organes reproducteurs mâles. A la suite d'un accouplement, les changements comportementaux et physiologiques caractérisant la réponse post-accouplement de la femelle, induits par le fluide séminal, sont affectés en absence de tictac chez les mâles. Grâce à l'analyse du transcriptome sur les organes reproducteurs mâles, je montre que l'absence de tictac conduit à une dérégulation transcriptionnelle de 150 gènes, dont 10% codent pour des composants du liquide séminal, montrant que tictac régule sa composition. La délétion spécifique de tic ou de tac, montre qu'ils ont des fonctions in vivo différentes mais que tous deux sont impliqués dans la synthèse du liquide séminal. L'analyse des glandes accessoires, l'organe fonctionnel équivalent de la prostate humaine fabriquant le fluide séminal, révèle que leur maturation et que leur fonction sécrétrice sont régulées par tictac. La recherche d'homologues de Tic et de Tac indique que Tic possède un domaine peptidique présentant une homologie avec un sous-domaine de RQC1 de levure, impliquée dans le contrôle qualité des ribosomes, alors que Tac possède un domaine serglycine, connu chez l'homme pour avoir des fonctions importantes dans la sécrétion. Ainsi, les peptides smORF Tic et Tac contribueraient à la synthèse et à la sécrétion des protéines du fluide séminal. Dans un second temps, j'ai mené l'analyse moléculaire de Sem1, une protéine intrinsèquement désordonnée connue pour interagir et réguler plusieurs complexes macromoléculaires. Comme ces données ont été générées dans des modèles in cellulo et in vitro, j'ai mené l'analyse moléculaire de Sem1 pour la première fois in vivo. J'ai montré que Sem1 est essentielle car sa délétion induit une létalité au stade larvaire. De plus, son absence entraine une apoptose massive se généralisant à l'ensemble du tissu de manière non-cellulaire autonome. Pour découpler les fonctions moléculaires de Sem1 et identifier le(s) domaine(s) protéique(s) essentiels à la survie cellulaire, j'ai généré pour chaque domaine fonctionnel une forme mutée, dont j'ai induit l'expression dans un contexte déplété de Sem1. Cette analyse structure-fonction met en évidence que les deux domaines interagissant avec l'ubiquitine sont essentiels au développement. En conclusion, mes travaux de thèse mettent en lumière de nouvelles fonctions des peptides smORF dans la reproduction et la survie cellulaire, illustrant la capacité des peptides smORF à agir sur de multiples complexes macro-moléculaires et contrôler ainsi de nombreux processus physiologiques<br>Recent technological advances have revealed that small ORFs (Open Reading Frame), which are less than 100 codons in size and were previously considered non-coding due to their small size, can be translated into thousands of smORF (small ORF) peptides in all organisms. Several studies have shown that smORF peptides can interact with canonical proteins and regulate their activity. Thus, the smORF peptide family represents a vast unexplored reservoir of potential regulators. A functional screen carried out in Drosophila identified new smORF peptides involved in development, several of which are derived from polycistronic RNA translation. My thesis research project was to characterize the function in Drosophila of 1) Tic and Tac, two unknown smORF peptides encoded by a bicistronic RNA, and 2) Sem1/DSS1, a highly conserved peptide. The first part of my thesis was to analyze the biological function of two unknown smORF peptides encoded by a bicistronic RNA that we named tictac. I demonstrated that Tic and Tac are two peptides translated from the same bicistronic RNA tictac, but with different AA sequences and cellular localization. In vivo, tictac is highly expressed in male reproductive organs. Following mating, behavioral and physiological changes characterizing the post-mating response in female, which are mainly induced by the seminal fluid, are affected in the absence of tictac in males. Using transcriptome analysis on male reproductive organs, I show that the absence of tictac leads to transcriptional deregulation of 150 genes. Among them, 10% code for seminal fluid components, proving that tictac regulates its composition. Specific deletion of either tic or tac highlights that they have different in vivo functions, but that both are involved in seminal fluid synthesis. The analysis of accessory glands, the functional seminal fluid-producing organ equivalent to the human prostate, reveals that their maturation and secretory function are regulated by tictac. The search for homologs of Tic and Tac indicates that Tic has a peptide domain with strong homology to a subdomain of RQC1, a yeast protein involved in ribosome quality control, and Tac has a serglycin domain, known in human to have important functions in secretion. My data therefore suggests that Tic and Tac smORF peptides may contribute to the synthesis and secretion of seminal fluid proteins. In a second step, I carried out the molecular analysis of Sem1, an intrinsically disordered protein known to interact with and regulate several macromolecular complexes. As these data were only generated in cellulo and in vitro models, I carried out the molecular analysis of Sem1 for the first time in vivo. I showed that Sem1 is essential, as its deletion induces lethality at the larval stage. Moreover, its absence leads to massive apoptosis that generalizes to the whole tissue in a non-cell-autonomous manner. To uncouple the molecular functions of Sem1 and identify the protein domains essential for cell survival, I generated a mutated form of each functional domain, then induced its expression in the absence of endogenous Sem1. This structure-function analysis revealed that two domains known to interact with ubiquitin are essential for development. In conclusion, my thesis work highlights new functions of smORF peptides in reproduction and cell survival, illustrating the ability of smORF peptides to act on multiple macro-molecular complexes, thus controlling numerous physiological processes
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Malass, Imane. "Design of an integrated streak camera based on a time correlated single photon counting system." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAD001/document.
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Nous présentons une caméra à balayage de fente intégrée basée sur un système de comptage de photon unique résolu en temps (TCSPC-SC) employant l'architecture linéaire « streak » pour surmonter la limitation de l'espace inhérent aux systèmes TCSPC bidimensionnels. Cette solution permet l'intégration de fonctionnalités électroniques complexes dans les pixels sans l'inconvénient d'un faible facteur de remplissage conduisant à une faible efficacité de détection. Le TCSPC-SC se compose de deux blocs principaux: une photodiode à avalanche (SPAD) et un bloc de mesure de temps, les deux blocs sont intégrés en technologie 180 nm CMOS standard. La structure de la SPAD utilisée a été sélectionnée parmi 6 structures différentes après un processus de caractérisation précise et approfondie. Le bloc de mesure du temps se compose d'un TOC hybride capable d'atteindre des résolutions de temps élevées et ajustables avec une large dynamique de mesure grâce à un système de conversion de temps (TOC) hybride qui combine l'approche analogique basée sur un convertisseur de temps vers amplitude(TAC), et les approches numériques utilisant une boucle à verrouillage de retard (DLL) et un compteur numérique. Le TOC hybride a été spécialement conçu pour être utilisé dans un système TCSPC qui intègre une ligne de TOC nécessitant ainsi une conception appropriée pour limiter la consommation d'énergie et la surface d'occupation et parvenir à une architecture flexible et facilement extensible. Suite à la conception et la réalisation de ces deux blocs dans une technologie180 nm CMOS standard, une structure de test de la caméra à balayage de fente (TCSPC-SC) qui englobe 8 unités a été réalisée dans le but final de mettre en œuvre un modèle TCSPC-SC complet et plus large<br>In this work we present a TCSPC Streak Camera (TCSPC-SC) that takes advantage of the streak mode imaging ta overcome the space limitation inherent ta 20 TCSPC sensor arrays. This cost-effective solution allows the integration of complex functionalities in the pixel without the inconvenience of low fill factor that leads ta low detection efficiency. The TCSPC~SC consists of two main building blacks: a SPAD and a time measurement black bath integrated in 180 nm Standard CMOS technology. The SPAD was selected among 6 different SPAD structures following a thorough characterization process ta fully determine its performance figures. The time measurement black consists of a hybrid TOC capable of achieving high adjustable time resolutions with large dynamic range owing ta a time conversion scheme that combines traditional Analog Time to Amplitude Converter (TAC), Digital DLL-based and counter-based TOC. Furthermore, thehybrid TOC was especially designed ta be used in a TCSPC system that incorporates an array of TDCs which required a careful design ta limit power consumption and occupation area in order to achieve a flexible and easily scalable architecture. These two building blacks were bath fabricated in a 180 nm standard CMOS technology and employed ta demonstrate a TCSPC Streak Camera(TCSPC-SC) test structure that englobes 8 units in order ta demonstrate the system's operation principle with the final aim of implementing a complete and bigger TCSPC-SC model in the near future
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Youssef, Daniel. "Návrh aplikace pro výukový model manipulátoru se třemi stupni volnosti." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231172.
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Tato práce popisuje další vývoj výukového sériového manipulátoru se třemi stupni volnosti. Práce se zabývá jednoduchou mechanickou úpravou manipulátoru, ale především pak softwarovou částí. Výsledkem je pak hra piškvorky, kdy manipulátor umožňuje hru proti lidskému protějšku. První část práce je věnována zlepšení inicializačního procesu manipulátoru a následně pak i návrhem vhodné polohové regulace. V další části je manipulátor rozšířen o jeden stupeň volnosti. Součástí je i návrh koncového efektoru vhodného pro psaní. Z takto upraveného manipulátoru je sestaven kinematický model vhodný pro real-time řízení. Dalším krokem v práci je návrh samotné aplikace hry piškvorky. Je navržen vhodný hrací algoritmus, včetně detekce a rozpoznání znaků v hracím poli pomocí kamery. Následně je vše implementováno do real-time aplikace, kde komunikaci s uživatelem zajišťuje navržené uživatelské rozhraní.
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COUTINHO, ANA C. de S. "Influência da adição de carbetos (NbC,TaC, SiC e TiC) na sinterização de cerâmicas à base de Sisub(3)Nsub(4)." reponame:Repositório Institucional do IPEN, 2005. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11351.
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Made available in DSpace on 2014-10-09T12:50:59Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:09:55Z (GMT). No. of bitstreams: 1
11324.pdf: 10687435 bytes, checksum: 865d33b683c2da8d9d7ce12197aa8245 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP<br>FAPESP:01/01889-4
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Steinwall, Lina, and Elinn Åkerlund. "Språk- och kommunikationsutvecklingi förskolan : Med fokus på Tecken som Alternativ och Kompletterande Kommunikation." Thesis, Umeå universitet, Institutionen för tillämpad utbildningsvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155343.
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För att idag kunna känna en delaktighet i samhället behöver varje människa kunna samspela. Detta samspel bygger på kommunikation med varandra. Det finns personer som har svårt för att kommunicera då det kan finnas ett språk och/eller en kommunikationsbarriär. För att komma över den här barriären kan man använda sig av stödtecken. I Sveriges förskolor arbetas det ibland med tecken som hjälpmedel. Denna teckenanvändning kallas för TAKK (Tecken som Alternativ och Kompletterande Kommunikation). Vårt syfte med rapporten var att ta reda på hur förskolor arbetar med tecken. Hur ofta de används, vad pedagogerna ser för utmaningar och möjligheter med det och om de anser att det kan vara till stöd för barnen i deras språk- och kommunikationsutveckling och i så fall på vilket sätt. För att få fram ett resultat utifrån detta syfte intervjuades sex stycken pedagoger i norra delen av Sverige. När vi analyserade intervjuerna gjorde vi en transkribering av vårt insamlade material. Därefter använde vi oss av fenomenografisk analysmetod. Detta kommer vi beskriva mer ingående i metodavsnittet. I resultatet framgick det att tecken endast användes i enstaka situationer men att pedagogerna skulle vilja arbeta mer med det. Pedagogerna såg många möjligheter med att använda TAKK och de menade bland annat att det kunde gynna barnens språkutveckling på olika sätt. Det fanns även utmaningar med TAKK som till exempel kunde vara att pedagogerna inte hade någon eller otillräckligt med utbildning inom TAKK vilket vi tolkar kan vara en nackdel. I rapporten kommer TAKK, tecken och tecken som stöd användas som synonymer.
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Baudry, Antoine. "Analyse fonctionnelle des protéines TT2, TT8 et TTG1 : étude de leur rôle dans la régulation de la biosynthèse des flavoni͏̈des chez Arabidopsis thaliana." Paris 11, 2004. http://www.theses.fr/2004PA112137.
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Au cours du développement de la graine d'Arabidopsis thaliana, les proanthocyanidines (PA) s'accumulent spécifiquement dans la couche la plus interne des téguments de la graine. Il a été montré précédemment que TT2 et TT8 codent, respectivement, pour des facteurs de transcription à domaine MYB et bHLH, impliqués dans la régulation du métabolisme des PA. Avec TTG1, une protéine à domaine WDR, ces facteurs régulent l'expression d'un gène codant pour une enzyme clé de la biosynthèse des PA : BANYULS (BAN). Nous avons étudié les interactions entre TT2, TT8, TTG1 et le promoteur de BAN. Les premiers résultats obtenus en utilisant des protéines de fusion avec le récepteur aux glucocorticoi͏̈des (GR) suggèrent fortement que TT2, TT8 et TTG1 peuvent activer directement l'expression de BAN. Des expériences de double-hybride ont démontré que ces protéines peuvent former un complexe stable. L'expression simultanée de TT2 et TT8 dans la levure s'est révélée suffisante pour permettre une liaison au promoteur de BAN, même si l'activité de ce complexe est corrélée au niveau d'expression de TTG1 chez A. Thaliana. Des expériences d'expression transitoire en protoplastes ont montré que TTG1 agit principalement par la régulation de l'activité du partenaire bHLH et que TT2 ne peut pas être remplacé par les MYB les plus proches d'A. Thaliana pour activer BAN. En accord avec ces résultats, l'expression ectopique de TT2 a été suffisante pour déclencher l'activation de BAN dans les parties végétatives, mais uniquement où TTG1 est exprimé. L'ensemble de ces résultats indique que TT2, TT8 et TTG1 forment un complexe contrôlant directement l'expression de BAN in planta<br>During Arabidopsis thaliana seed development, proanthocyanidins accumulate specifically in the most inner cell layer of the seed coat. Previous results have demonstrated that TT2 and TT8 encode an R2R3-MYB and a bHLH transcription factors involved in the regulation of PA metabolism, respectively. Together with TTG1, a WD-Repeat protein, these factors regulate the expression of the gene encoding a core enzyme of PA biosynthesis: BANYULS (BAN). We investigated the interplays between TT2, TT8, TTG1 and the BAN promoter. Results obtained using chimeric protein with the Glucocorticoid Receptor (GR) in planta strongly suggested that TT2, TT8, and TTG1 can directly activate BAN expression. Experiments using yeast two- and three-hybrid clearly demonstrated that TT2, TT8, and TTG1 can form a stable ternary complex. Furthermore, although TT2 and TT8 were able to bind to the BAN promoter when simultaneously expressed in yeast, the activity of the complex correlated with the level of TTG1 expression in A. Thaliana. In addition, transient expression experiments revealed that TTG1 acts mainly through the bHLH partner (i. E. TT8, GL3 or EGL3) and that TT2 cannot be replaced by any other related A. Thaliana MYB protein (e. G. PAP1) to activate BAN. Consistently with these results, the ectopic expression of TT2 was sufficient to trigger BAN activation in vegetative parts of the plant, but only where TTG1 is expressed. Taken together, these results indicated that TT2, TT8, and TTG1 can form a ternary complex directly regulating BAN expression in planta
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Ascencio, Arizola Nahomy Maricruz, Cabellos Karina Alicia Saldaña, Portugal Andrea Alejandra Sánchez, Palpan Fiorella Lesly Solorzano, and Pari Vanessa Uscapi. "TRAMI-TEC." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/656947.
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En la actualidad, todas las personas tienen miedo de contagiarse del COVID-19, es por ello que buscan soluciones óptimas y eficientes, que no involucren tanto contacto con otras personas, por medio de las nuevas tecnologías. Además, se ha visto un incremento en el uso de metodologías y sistemas ágiles para acelerar determinados procesos, que involucran gran pérdida de tiempo y dinero. Un gran ejemplo; es el uso de los medios digitales como intermediario para contactar a un experto legal y administrativo con el objetivo de que realice determinados trámites sin necesidad de que el cliente salga de su casa, se exponga al covid y realice colas afuera de la institución para solicitar asesoría; evitando así, pérdida de tiempo y mal humor. Por estas razones, hemos visto una oportunidad de negocio para generar valor en dichas personas; la cual se basa en la resolución de trámites más solicitados en la actualidad con la ayuda de profesionales capacitados y las nuevas redes de contacto, que permiten que todo sea más rápido y eficiente.
En este presente trabajo, se procederá a desarrollar una investigación con el fin de ver la viabilidad y rentabilidad de nuestro proyecto con el fin de poder proceder a comercializar dicho servicio. Asimismo, se aplicará y desarrollará los conocimientos aprendidos durante el transcurso de la carrera al tratar temas relacionados a distintas áreas como finanzas, marketing, negocios internacionales, logística, entre otros.<br>At present, all people are afraid of catching COVID-19, which is why they seek optimal and efficient solutions, which are not involved as much contact with other people, through new technologies. In addition, there has been an increase in the use of agile methodologies and systems for certain processes, which involve a great loss of time and money. A great example; is the use of digital media as an intermediary to contact a legal and administrative expert in order to carry out certain procedures without the need for the client to leave their home, expose themselves to covid and queue outside the institution to request advice ; thus avoiding waste of time and bad mood. For these reasons, we have seen a business opportunity to generate value in these people; which is based on the resolution of the most requested procedures nowadays with the help of trained professionals and the new contact networks, which allow everything to be faster and more efficient.
In this present work, an investigation will be carried out in order to see the viability and profitability of our project in order to be able to proceed to commercialize said service. Likewise, the knowledge learned during the course of the degree will be applied and developed by dealing with issues related to different areas such as finance, marketing, international business, logistics, among others.<br>Trabajo de investigación
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Sista, Subrahmanya Srivathsava. "Adversarial Game Playing Using Monte Carlo Tree Search." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479820656701076.
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Wilde, James Richard. "Ni+TaC nanocomposites." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621704.
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Conte, Nathalie [Aude]. "TACC-TIC cellulaires." Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX22079.
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Arosemena, Almanza Amed. "Aditivos Pro Tec." Tesis, Universidad de Chile, 2016. http://repositorio.uchile.cl/handle/2250/145825.
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TESIS PARA OPTAR AL GRADO DE MAGÍSTER EN MARKETING<br>La República de Panamá como país no productor de petróleo, se ve condicionado a la
adquisición de sus derivados con base en las oscilaciones del precio del mercado internacional.
Una rebaja en los derivados del crudo nace precisamente de la competencia por parte de los
oferentes (productores), entre los que extraen con tecnología tradicional y los que emplean
tecnología más perfeccionada para extraer petróleo del esquisto. Esto impacta directamente a
los consumidores finales, los cuales cuando conducen en la ciudad o realizan viajes más largos,
desean ahorrar dinero en la bomba de gasolina.
El rendimiento de motores puede elevarse o compensarse con la utilización de
productos químicos que mejoran las propiedades del combustible y del aceite, permitiendo que
funcionen de mejor manera. En este sentido, el uso de aditivos contribuye a eliminar las
impurezas del sistema de combustión y de lubricación. A pesar de sus beneficios, en términos
de ahorros y prolongación de la vida útil del auto, en el mercado panameño se puede notar una
ausencia de concienciación sobre los beneficios reales que ofrece un motor de auto limpio para
prolongar su vida útil así como el ahorro de combustible. Un punto no explotado en campañas
de marketing, dirigidas a este segmento.
Seguidamente se presenta un plan de marketing para la promoción de Engine Flush,
aditivo desarrollado y comercializado por PRO TEC, el cual ha sido estructurado en tres partes.
En su primera sección, se presenta un análisis situacional del mercado de aditivos en
Panamá, permitiendo establecer una posición más clara respecto al tema, desde la perspectiva
del Marketing, evaluando sus principales afectaciones positivas y negativas respecto al entorno
y sus grupos de interés, para determinar planes tácticos de acción. La segunda parte de este
documento establece el marco general de un Plan Estratégico de Mercadeo. Dicha planeación
comprende, entre otros puntos, la definición de objetivos de mercadotecnia, viabilidad de la
propuesta, barreras o limitaciones, estrategia creativa y de comunicación, selección de medios y
presupuesto de una campaña, correspondiente de enero a diciembre 2017, que apoyará la
promoción del producto antes mencionado. Finalmente, en su tercera parte, se establecen y
sugieren, tanto métricas como sus respectivos instrumentos, que permitan monitorear el
cumplimiento de los objetivos del plan de marketing y definir otras posibles ejecutorias.
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Sakalauskaitė, Giedrė. "Sergančiųjų TBC ir medicinos personalo žinių lygis apie TBC Vilniaus mieste." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20101125_185300-26523.
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Darbo tikslas: Išnagrinėti Vilniaus mieste sergančiųjų TBC ir šeimos gydytojų žinių lygį apie TBC; Uždaviniai: 1. Nustatyti, kaip pagrindinius faktus apie tuberkuliozę žino Vilniaus miesto Šeimos gydytojai; 2. Nustatyti, kaip pagrindinius faktus apie tuberkuliozę žino Vilniaus miesto sergantys tuberkulioze; Tuberkuliozė - infekcinė liga, kurią sukelia tuberkuliozės mikobakterijos, perduodamos oro lašeliniu būdu. Iš viso sergančiųjų yra apie 20 mln., maždaug pusė jų – sergantys atvira tuberkulioze. Atviros tuberkuliozės priežastys – nereguliarus ir netinkamas gydymas. Galima būtų teigti, kad atviros tuberkuliozės plitimą įtakoja medicinos pagalbos sistemos spragos, tačiau remiantis PSO duomenimis, tik apie 10 proc. sveikatos problemų sprendžia medicinos pagalbos sistema, 20 proc. priklauso nuo genetinio pagrindo, 20 proc. aplinkos, kurioje gyvename, 50 proc. nuo gyvensenos. Tuberkuliozė – socialinė problema, kurią galima būtų išspręsti sujumgus individo ir visuomenės, bei jos struktūrų pastangas plėtojant efektyvią profilaktiką ir medicinos pagalbą. Todėl galima teigti, kad BPG gydytojų ir sergančiųjų TBC žinių lygio įvertinimas yra aktuali problema, tiek teorijos, tiek praktikos, tyrimų atžvilgiu. Tyrimo metodika. Tyrimas buvo atliktas, Vilniaus mieste, Všį VUL Santariškių klinikų Šeimos centre, Centro poliklinikoje, Šeškinės poliklinikoje, Respublikinėj tuberkuliozės ir plaučių ligų ligoninėje. Kiekybiniam tyrimui atlikti buvo apklausta 62 respondentai, šeimos gydytojai ir... [toliau žr. visą tekstą]<br>Purpose of Work: Patients' with Tuberculosis and Family Doctors' Level of Knowledge about Tuberculosis in Vilnius City.Goals: 1. To evaluate how family doctors know basic facts about tuberculosis in Vilnius City. 2. To evaluate how ill with tuberculosis know basic facts about tuberculosis in Vilnius City General characteristic and relevance of the theme. Tuberculosis is infectious disease, which is caused by tuberculosis mycobacteria, transferred through the air when a person with TB of the lungs or throat coughs, sneezes or talks. There are 20 million people ill with TBC, about half of them – ill with open tuberculosis. Irregular and improper treatment is main cause of open tuberculosis. We can claim that spread of open tuberculosis is influenced by gaps of health system, however, according to WHO data, only 10 per cent of medical problems are solved by health system, 20 per cent depend on genetic background, 20 per cent on living surroundings, and 50 per cent on lifestyle. Tuberculosis is a social problem, which can be solved by joint individual and public and its structures efforts expanding effective prevention and system of medical help. Therefore we can claim, that evaluation of knowledge of medical doctors and TBC patients is a hot problem, in regard of both theoretical and practical research. Research modes. Research was carried out in Vilnius City, Public Enterprise VUH Santariškių Clinic Family Center, Center Clinic, Šeškinė Clinic, and Republic Hospital of... [to full text]
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Kong, Jia Huey. "SINTERING PROPERTIES OF TiC-Ni-Mo CERMET USING NANOSIZED TiC POWDERS." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/theses/1898.
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The sintering behavior to form TiC-Ni-Mo cermet using a nano-size TiC powders was investigated in flowing Argon gas at 1500°C. Nano-sized titanium carbide powders with high purity, high surface area, and low cost were synthesized from carbon coated Ti containing precursors utilizing a patented process. The sintering studies showed that an increase in theoretical density (TD) with increasing molybdenum content. TiC based cermets were characterized using X-ray diffraction (XRD), Vickers hardness, and scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS). Mechanical properties, electrical conductivity and oxidation resistance results shows potential applications as interconnect for Low/Intermediate Temperature Solid Oxide Fuel Cells (SOFC) and machining tool tips.
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Briki, Jalel. "Rôle exercé par une addition de manganèse sur le comportement structural des fontes à graphite sphéroïdal." Paris 11, 1985. http://www.theses.fr/1985PA112298.
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L’étude de l'influence exercée par le manganèse sur le comportement structural des fontes GS a concerné des matériaux contenant de 0,26 à 2,15 % pds Mn. A l'état brut de coulée, l'accroissement de la teneur en manganèse favorise nettement la structure perlitique. Le comportement au chauffage de la fonte riche en manganèse s'avère similaire à celui de la fonte non chargée en cet élément, excepté en ce qui concerne le phénomène de graphitisation dont la cinétique est fortement ralenti Les courbes des diagrammes TRC de la fonte GS (tracées à partir de 930°C) sont d'autant plus déportées vers les temps croissants que la teneur en manganèse excède 1 à 1 ,5% pds : ce fait traduit une amélioration sensible de la trempabilité (Vc = 5°/s). Lors des trempes étagées, le comportement de l'austénite enrichie en manganèse (teneur > 1 ,5% pds) se caractérise en particulier par la possibilité - entre ‘10 et 580°C - de développer la précipitation d'une cémentite substitué en Mn et Si. Le diagramme TTT est également déplacé vers les temps croissants en fonction de l'augmentation de la teneur en Mn. A la faveur d'un revenu de la structure, résultant d'une trempe préalable à 20°C et pour une concentration en Mn supérieure à 1,5 % pds, l'austénite résiduelle (ϒR) évolue en deux temps : rejet du carbone en excès sous forme d'une cémentite substituée (Mn + Si) et formation concomitante d’une austénite appauvrie ϒa; cette dernière se transforme en (α + carbures) lors d'une deuxième étape<br>The influence of manganese on the structural behaviour of spheroidal graphite cast iron was investigated in samples containing, 26 to 2. 15 wt % Mn. In the as-cast state, increasing the amount of manganese assists the development of a perlitic structure. On heating the behaviour of the material enriched in Mn, is similar to that of the unalloyed cast iron; nevertheless, kinetics of graphitization is considerably reduced. Transformation diagrams on continuous cooling (CCT) drawn from 930°C are shifted towards longer long-term as the percentage of manganese exceeds 1. 5 wt % this leads to a better quenchability (Vc > 5°/s). During isothermal treatments, austenite enriched in Mn (> 1. 5 wt %). May transform to a cementite with substitutional elements (Mn and/or Si). The isothermal transformation diagrams (TTT) are also shifted towards longer time as Mn content more and more important. When tempering the structure previously quenched down to ambient (and with Mn > 1. 5 wt %), the residual austenite ϒR transforms in two steps: rejection of carbon in excess in a (Mn + Si) substituted cementite with correlative impoverishment of the austenitic phase, this later ϒa phase being decomposed into (α+ carbide)during the second stade
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Gao, Yong 1955. "The behavior of TaC and TaC+Al electrodes in TiCL4 plasma gases /." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60022.
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An experimental study was carried out to identify a suitable electrode material for the treatment of TiCl$ sb4$ in a plasma arc. The behavior of the arc voltage, velocity and rate of electrode erosion were examined in a DC plasma torch using concentric cylindrical electrodes and arc rotation by an axial magnetic field. The results of the experiments and analyses showed that pure TaC was not suitable as an electrode material because of its mechanical failure under thermal stress. A new composite material, TaC infiltrated with Al proved to be successful.<br>Stable plasmas were produced containing up to 30% titanium tetrachloride in argon at a current of 100 amperes, an interelectrode gap of 4 mm, and a magnetic field strength of 1000 Gauss. The cathode erosion rate was less than 30 micrograms/C at a titanium tetrachloride concentration of 14.3%.
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Chávez, Monteblanco Álvaro Jorge, Medina James Javier Castillo, and Loli Sandra Pamela Torres. "Tu pequeño constructor - TPC." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/623436.
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El proyecto escogido tiene como nombre “Tu Pequeño Constructor” y utilizará las siglas TPC. Esta idea de negocio nace con la expectativa de cubrir una demanda insatisfecha del mercado peruano de juguetes alternativos el cual consta de construir estructuras con pequeños ladrillos hechos a base de arcilla según un modelo pre establecido, el mismo que se podrá pintar, pegar y diseñar a su gusto. El valor agregado es que la estructura construida logrará ser apreciada y compartida en las redes sociales, además de añadir un foco led a la construcción.<br>Trabajo de investigación
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Robertson, Mary M. "What makes us tic?" Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/17485.
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Flores, Panta Mary Rosy, Zumaeta Margiorith Liliana Gilio, Rosillo Ivette Anel Saldarriaga, and Vilchez Valeria Lizeth Junnet Girón. "TEC Técnico en casa." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/652641.
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El presente trabajo de investigación tiene por objeto la creación de una plataforma virtual útil para conectar a técnicos y clientes que deseen satisfacer una necesidad técnica a domicilio en el menor tiempo posible. Además, mediante la plataforma virtual se garantizará la seguridad y calidad de los servicios a ofrecer, ya que la selección de técnicos será minuciosa para realizar dicho contacto. En suma, para rectificar nuestro servicio de calidad, se realizará una supervisión del servicio realizado, con el objeto de realizar mejoras y ofrecer beneficios a los clientes, en caso que el cliente no esté a gusto con el servicio ofrecido. La idea de negocio surge a consecuencia de una necesidad frecuente como reparar objetos domésticos y, ello se dificulta ante el requerimiento de un experto con experiencia y que, a su vez, éste sea confiable. Añadido a esto, contratan a trabajadores informales que proliferan sus capacidades técnicas en lugares peligrosos, pero que forman parte de su marketing personal. En los primeros apartados, se apreciará los aspectos más importantes y relevantes para el entendimiento del proyecto como es el caso del modelo del negocio, sus validaciones, estudios de mercado, entre otros puntos. En el presente documento se analiza la viabilidad y escalabilidad del negocio y se desarrollara la proyección de ventas a partir del plan concierge de TEC, asimismo, la planeación estratégica, los planes entre ellos el operativo, de marketing y financiero, definidos así por áreas. Posteriormente, se presenta un análisis cuantitativo y cualitativo de dichos planes mediante los estados financieros. Por último, se desarrolla un breve resumen de lo más importante por medio de conclusiones.<br>The purpose of this research work is to create a useful virtual platform to connect technicians and clients who wish to satisfy a technical need at home in the shortest possible time. In addition, the virtual platform will guarantee the safety and quality of the services to be offered, since the selection of technicians will be meticulous to make such contact. In short, to rectify our quality service, a supervision of the service performed will be carried out, in order to make improvements and offer benefits to customers, in case the customer is not comfortable with the service offered.
The business idea arises as a result of a frequent need such as repairing household objects and this is hindered by the requirement of an experienced expert who, in turn, is reliable. Added to this, they hire informal workers who proliferate their technical skills in dangerous places, but who are part of their personal marketing.
In the first sections, the most important and relevant aspects for understanding the project will be appreciated, such as the business model, its validations, market studies, among other points.
This document analyzes the viability and scalability of the business and will develop the sales projection based on TEC's concierge plan, as well as strategic planning, including operational, marketing and financial plans, defined by area. Subsequently, a quantitative and qualitative analysis of these plans is presented through the financial statements.
Finally, a brief summary of the most important is developed through conclusions.<br>Trabajo de investigación
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Verdier, Benoît. "TIC et groupes sociaux /." Paris : Hermès science publications-Lavoisier, 2007. http://catalogue.bnf.fr/ark:/12148/cb41164095h.
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