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1

Tzvetkov, Petre, Xifeng Yan, and Jiawei Han. "TSP: Mining top-k closed sequential patterns." Knowledge and Information Systems 7, no. 4 (May 2005): 438–57. http://dx.doi.org/10.1007/s10115-004-0175-4.

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2

Farbstein, Boaz, and Asaf Levin. "Deadline TSP." Theoretical Computer Science 771 (June 2019): 83–92. http://dx.doi.org/10.1016/j.tcs.2018.11.016.

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3

Armon, Amitai, Adi Avidor, and Oded Schwartz. "Cooperative TSP." Theoretical Computer Science 411, no. 31-33 (June 2010): 2847–63. http://dx.doi.org/10.1016/j.tcs.2010.04.016.

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4

Chaourar, Brahim. "The Kth TSP is pseudopolynomial when TSP is polynomial." Discrete Mathematics, Algorithms and Applications 10, no. 05 (October 2018): 1850058. http://dx.doi.org/10.1142/s1793830918500581.

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Given an undirected graph [Formula: see text] with a weight function [Formula: see text], and a positive integer [Formula: see text], the Kth Traveling Salesman Problem (Kth TSP) is to find [Formula: see text] Hamilton cycles [Formula: see text] such that, for any Hamilton cycle [Formula: see text], we have [Formula: see text]. This problem is NP-hard even for [Formula: see text] fixed. We prove that Kth TSP is pseudopolynomial when TSP is polynomial.
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5

Barlow, David, and David M. Lilien. "Micro TSP 7.0." Economic Journal 102, no. 410 (January 1992): 191. http://dx.doi.org/10.2307/2234878.

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6

Pesch, Erwin, and Fred Glover. "TSP ejection chains." Discrete Applied Mathematics 76, no. 1-3 (June 1997): 165–81. http://dx.doi.org/10.1016/s0166-218x(96)00123-0.

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7

Farbstein, Boaz, and Asaf Levin. "Discounted Reward TSP." Algorithmica 80, no. 2 (December 12, 2016): 472–95. http://dx.doi.org/10.1007/s00453-016-0264-2.

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8

Martens, Rainer. "TSP Publisher Statement." Sport Psychologist 1, no. 1 (March 1987): 1. http://dx.doi.org/10.1123/tsp.1.1.1.

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9

Shi, X. H., Y. C. Liang, H. P. Lee, C. Lu, and Q. X. Wang. "Particle swarm optimization-based algorithms for TSP and generalized TSP." Information Processing Letters 103, no. 5 (August 2007): 169–76. http://dx.doi.org/10.1016/j.ipl.2007.03.010.

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10

Hwang, Sook-Hi, Il-Yong Weon, Sung-Bum Ko, and Chang-Hoon Lee. "S-MINE Algorithm for the TSP." KIPS Transactions:PartB 18B, no. 2 (April 30, 2011): 73–82. http://dx.doi.org/10.3745/kipstb.2011.18b.2.073.

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11

Cho, Jun-Hyon, and Jong-Han Kim. "A Proximal Mapping Method for TSP." Journal of Institute of Control, Robotics and Systems 28, no. 12 (December 31, 2022): 1103–8. http://dx.doi.org/10.5302/j.icros.2022.22.0132.

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12

Ban, Ha-Bang, and Dang-Hai Pham. "Multifactorial Evolutionary Algorithm for Simultaneous Solution of TSP and TRP." Computing and Informatics 40, no. 6 (2021): 1370–97. http://dx.doi.org/10.31577/cai_2021_6_1370.

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13

Kowalik, Łukasz, Shaohua Li, Wojciech Nadara, Marcin Smulewicz, and Magnus Wahlström. "Many-visits TSP revisited." Journal of Computer and System Sciences 124 (March 2022): 112–28. http://dx.doi.org/10.1016/j.jcss.2021.09.007.

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14

S.Choubey, Nitin. "Solving TSP using DARO." International Journal of Computer Applications 58, no. 9 (November 15, 2012): 28–31. http://dx.doi.org/10.5120/9311-3543.

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15

Plumelle, Y. "HAM/TSP pathogenesis hypothesis." Medical Hypotheses 52, no. 6 (June 1999): 595–604. http://dx.doi.org/10.1054/mehy.1998.0714.

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16

Manthey, Bodo. "On approximating multicriteria TSP." ACM Transactions on Algorithms 8, no. 2 (April 2012): 1–18. http://dx.doi.org/10.1145/2151171.2151180.

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17

Cohen, J. H., W. C. Maurer, and P. A. Westcott. "High-Power TSP Bits." Journal of Energy Resources Technology 116, no. 1 (March 1, 1994): 33–37. http://dx.doi.org/10.1115/1.2906007.

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This paper reviews a three-year R&D project to develop advanced TSP bits that can operate at power levels 5 to 10 times greater than those typically delivered by rotary rigs. These bits are designed to operate on advanced drilling motors that drill 3 to 6 times faster than rotary rigs. TSP bit design parameters that were varied during these tests include cutter size, shape, density, and orientation. Drilling tests conducted in limestone, sandstone, marble, and granite blocks showed that these optimized bits drilled many of these rocks at 500 to 1000 ft/hr (150 to 300 m/h), compared to 50 to 100 ft/hr (15 to 30 m/h) for roller bits. These tests demonstrated that TSP bits are capable of operating at the high speeds and high torques delivered by advanced drilling motors now being developed. These advanced bits and motors are designed for use in slim-hole and horizontal drilling applications.
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18

Gent, Ian P., and Toby Walsh. "The TSP phase transition." Artificial Intelligence 88, no. 1-2 (December 1996): 349–58. http://dx.doi.org/10.1016/s0004-3702(96)00030-6.

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19

Engebretsen, Lars, and Marek Karpinski. "TSP with bounded metrics." Journal of Computer and System Sciences 72, no. 4 (June 2006): 509–46. http://dx.doi.org/10.1016/j.jcss.2005.12.001.

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20

Leon-S., Fidias E., and Tomas A. Alarcon. "HAM/TSP in Ecuador." Transactions of the Royal Society of Tropical Medicine and Hygiene 89, no. 3 (May 1995): 342. http://dx.doi.org/10.1016/0035-9203(95)90576-6.

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21

Silk, Julian. "TSP 4.4: a review." Journal of Applied Econometrics 12, no. 4 (July 1997): 445–53. http://dx.doi.org/10.1002/(sici)1099-1255(199707)12:4<445::aid-jae448>3.0.co;2-c.

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22

WANG, WEI-CHI, YANBIN LI, MICHAEL F. SLAVIK, and HUA XIONG. "Trisodium Phosphate and Cetylpyridinium Chloride Spraying on Chicken Skin to Reduce Attached Salmonella typhimurium." Journal of Food Protection 60, no. 8 (August 1, 1997): 992–94. http://dx.doi.org/10.4315/0362-028x-60.8.992.

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Spraying treatments with trisodium phosphate (TSP) and cetylpyridinium chloride (CPC) were evaluated for their effectiveness in reducing Salmonella typhimurium attached to chicken skins. Chicken skins with an area of 38.5 cm2 were cut from the breast areas of pre-chill chicken carcasses, mounted in a plastic holder, and inoculated with S. typhimurium. The inoculated skins were sprayed with tap water, 10% (wt/vol) TSP, or 0.1 % CPC solutions at 10, 35, or 60°C and 206.8, 413.7, 620.5, 827.4, or 1034.2 kPa for 30 s. After spraying, each skin was rinsed with tap water, transferred to a plastic bag containing 50 ml buffered peptone water, and stomached for 1 min. The stomaching water was collected, diluted serially, plated on xylose lysine tergitol 4 (XLT4) agar and Petrifilm aerobic count plates, and incubated for 18 to 24 h at 37°C. The results showed that tap water spraying reduced S. typhimurium by 0.7 to 1.6 log, while the reduction ranges for TSP and CPC spraying treatments were 1.6 to 2.3 and 1.5 to 2.5 log, respectively. Greater reductions in the numbers of S. typhimurium were obtained in TSP spraying treatments in the high pressure range (620.5 to 1034.2 kPa) and in CPC spraying treatments at 10°C.
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23

CAPITA, ROSA, CARLOS ALONSO-CALLEJA, MIGUEL PRIETO, MARÍA del CAMINO GARCÍA-FERNÁNDEZ, and BENITO MORENO. "Effectiveness of Trisodium Phosphate against Listeria monocytogenes on Excised and Nonexcised Chicken Skin." Journal of Food Protection 66, no. 1 (January 1, 2003): 61–64. http://dx.doi.org/10.4315/0362-028x-66.1.61.

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The influence of sample type (i.e., excised versus nonexcised chicken skin) on the efficiency of trisodium phosphate (TSP) solutions in reducing Listeria monocytogenes populations and inhibiting their growth during refrigerated storage was studied. Whole chicken legs and excised chicken leg skin fragments inoculated with 108 CFU of L. monocytogenes per ml were dipped for 15 min in sterile tap water (control) or in a solution containing 8, 10, or 12% TSP. L. monocytogenes counts were determined after 0, 1, 3, and 5 days of refrigerated storage (2°C). The decontamination effect of TSP was greater for excised skin than for whole legs. Microbial differences between control and TSP-treated samples were significantly larger for excised skin than for whole legs for 9 (75%) of 12 tested combinations of TSP concentrations and storage times. These differences varied from 1.05 ± 0.26 log10 cycles (day 1) to 3.30 ± 0.14 log10 cycles (day 5) for nonexcised-skin samples (whole legs) and from 1.54 ± 0.48 log10 cycles (day 1) to 4.28 ± 0.86 log10 cycles (day 5) for excised-skin samples. Significantly larger reductions were observed from the third day of refrigerated storage onward. The TSP concentration was a significant factor in the reduction of L. monocytogenes populations. These results suggest that bacteria are more readily accessible to TSP in excised than in nonexcised chicken skin and that the type of sample used to ascertain the efficacy of antimicrobial surface treatments may influence the findings of this type of study.
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24

Ficoń, Krzysztof. "DUALIZM LOGISTYCZNO-KOMBINATORYCZNY ZADANIA KOMIWOJAŻERA." Systemy Logistyczne Wojsk 1, no. 42 (July 10, 2015): 45–64. http://dx.doi.org/10.5604/01.3001.0012.7153.

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W pracy został przedstawiony dualny charakter problemu komiwojażera (TPS -Travelling Salesman Problem), który może być jednocześnie rozpatrywany jako utylitarne zadanie transportowe według kryteriów logistycznych oraz jako złożony problem kombinatoryczny optymalizacji dyskretnej. W aspekcie optymalizacyjnym zadanie TSP należy do problemów NP-zupełnych, dla których w ogólności nie istnieją efektywne metody rozwiązań. Ze względu na bardzo szeroki zakres logistycznych aplikacji zadania TSP dokonano prezentacji najbardziej popularnych metod jego rozwiązania. Szczególną uwagę zwrócono na nowoczesne podejście oparte na metodach sztucznej inteligencji i algorytmach mrówkowych. Klasyczny problem TSP jest szczególnym przypadkiem bardzo ważnego we współczesnej logistyce wielowymiarowego problemu marszrutacji rzutującego m.in. na globalne koszty działalności transportowej i logistycznej
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25

Rybickova, Ing Alena, Ing DenisaMockova Ing. DenisaMockova, and Ing Bc AdelaKaraskova Ing.Bc. AdelaKaraskova. "Application of Genetic Algorithm to The TsP Problem." Paripex - Indian Journal Of Research 3, no. 7 (January 1, 2012): 1–3. http://dx.doi.org/10.15373/22501991/july2014/35.

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26

Setty, Yamaja B. N., Suhita Gayen Betal, Surekha Kulkarni, and Marie J. Stuart. "Phosphatidylserine (PS)-Positive Erythrocytes Bind to Both Immobilized and Soluble Thrombospondin-1 (TSP-1) Via Its Heparin Binding Domain." Blood 108, no. 11 (November 16, 2006): 1568. http://dx.doi.org/10.1182/blood.v108.11.1568.1568.

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Abstract Phosphatidylserine (PS)-dependent erythrocyte adhesion to both cultured endothelial cells and the components of sub-endothelial matrix appears to be mediated in part via thrombospondin-1 (TSP). While TSP exhibits multiple cell-binding domains, the PS-binding site on TSP has not been identified. Since a cell-binding domain for anionic heparin is located at the amino-terminal domain of TSP, we hypothesized that anionic PS-positive (PS+ve) red cells bind to this domain. In a recent preliminary study, using a flow adhesion system and PS+ve erythrocytes (prepared by treating control AA red cells with A23187), we have demonstrated that heparin inhibited PS+ve erythrocyte adhesion to immobilized TSP in a concentration-dependent manner with 58 to 77% inhibition noted at concentrations between 1 and 50 U/ml (n=9, P<0.001). Other anionic polysaccharides including high molecular weight dextran sulfate and chondroitin sulfate A also inhibited PS+ve erythrocyte adhesion to immobilized TSP with the magnitude of the inhibitory effects comparable to heparin. These results suggested that the heparin-binding domain on TSP may be involved in PS-mediated red cell adhesion to immobilized TSP. We have extended these studies to characterize the PS-binding site on TSP using monoclonal antibodies directed against specific cell-binding domains on the molecule and also using specific TSP peptides. We demonstrate that pre-incubation of immobilized TSP with an antibody directed against the heparin-binding domain on TSP (TSP-Ab9, Lab Vision) blocked PS-mediated red cell adhesion to immobilized TSP (80% inhibition compared to an isotype-matched negative control antibody, n=7, P<0.001), whereas an antibody that recognizes the collagen-binding domain on TSP (TSP-Ab4) did not affect this process. In addition, incubation of PS+ve erythrocytes with a TSP peptide containing the specific heparin-binding motif, KKTRG, inhibited PS-mediated red cell adhesion by 55% (P<0.001, n=6), whereas a peptide lacking the binding motif had no effect. Since protein confirmation of immobilized TSP appears to be different from that of soluble TSP, we next investigated whether soluble TSP, like immobilized TSP, also interacted with PS+ve erythrocytes. Erythrocytes containing 8 to 10% PS+ve cells were incubated in the absence or the presence of increasing concentrations of soluble TSP (0.1 to 10 μg/ml), and then analyzed by flow cytometry for surface bound TSP using both adhesion blocking (TSP-Ab9) and non-blocking (TSP-Ab4) anti-TSP antibodies. We demonstrate that soluble TSP binds to PS+ve erythrocytes in a concentration-dependent manner with 3 to 11% TSP-positive (TSP+ve) red cells measured at soluble TSP concentrations between 1 to 10 μg/ml (n=4). In addition, TSP binding could be detected only with the non-adhesion blocking antibody TSP-Ab4, which recognizes the collagen-binding domain on TSP. The adhesion blocking antibody TSP-Ab9 that interacts with the heparin binding domain, failed to detect any TSP+ve red cells. No TSP+ve erythrocytes were detected when PS-negative control red cells were evaluated in binding assays. In parallel adhesion experiments, soluble TSP inhibited PS+ve erythrocyte adhesion to immobilized TSP at concentrations at which significant TSP binding to erythrocytes occurred (43% and 44% inhibition at 5 and 10 μg of soluble TSP per ml, n=4). These results conclusively demonstrate that PS-positive erythrocytes interact with both immobilized and fluid phase TSP through the heparin-binding domain, and that heparin blocks this interaction.
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27

CAPITA, ROSA, CARLOS ALONSO-CALLEJA, ROBERTO RODRÍGUEZ-PÉREZ, BENITO MORENO, and MARÍA del CAMINO GARCÍA-FERNÁNDEZ. "Influence of Poultry Carcass Skin Sample Site on the Effectiveness of Trisodium Phosphate against Listeria monocytogenes." Journal of Food Protection 65, no. 5 (May 1, 2002): 853–56. http://dx.doi.org/10.4315/0362-028x-65.5.853.

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The aim of this study was to determine the influence of skin sample site on the efficacy of trisodium phosphate (TSP) solutions in reducing Listeria monocytogenes populations on chicken carcasses during refrigerated storage. Chicken skin samples from the legs, the breasts, and the dorsal area inoculated with L. monocytogenes (108 CFU/ml) were dipped for 15 min in sterile tap water (control) or in 8, 10, or 12% TSP. L. monocytogenes counts and surface pH values were determined after 0, 1, 3, and 5 days of storage at 2°C. For all sampling times and TSP concentrations, the reductions in L. monocytogenes numbers in breast skin were significantly larger (P &lt; 0.05) than those in leg skin or dorsal skin. No significant differences were found in pH values as an effect of skin site. Our results suggest that skin sampling site is an important factor that needs to be considered when decontamination protocols are developed for poultry carcasses with the TSP treatment.
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28

NAKAKITA, Kazuyuki, Yosuke SUGIOKA, and Hiroki NAGAI. "Unsteady PSP/TSP Measurement Techniques." Journal of the Visualization Society of Japan 38, no. 148 (2018): 3–9. http://dx.doi.org/10.3154/jvs.38.148_3.

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29

Jones, Scott, P. Mark Kayll, Bojan Mohar, and Walter D. Wallis. "On constant-weight TSP-tours." Discussiones Mathematicae Graph Theory 23, no. 2 (2003): 287. http://dx.doi.org/10.7151/dmgt.1203.

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30

Y, Sreenuvasulu, Vijayalakshmi R, Somasekhar Srinivas .V K, and Sundaramurthy M. "Three Dimensional Constrained P-Tsp." IOSR Journal of Mathematics 12, no. 04 (April 2016): 69–83. http://dx.doi.org/10.9790/5728-1204016983.

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31

Kubota, Ryuji. "Clinical diversity of HAM/TSP." Rinsho Shinkeigaku 51, no. 11 (2011): 1044–46. http://dx.doi.org/10.5692/clinicalneurol.51.1044.

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32

Duník, Barbora, and Robert Lukoťka. "Cubic TSP: A 1.3-Approximation." SIAM Journal on Discrete Mathematics 32, no. 3 (January 2018): 2094–114. http://dx.doi.org/10.1137/15m1032247.

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33

Slater, Carla Maria Sena Andrade, Luiz Claudio Pereira Ribeiro, and Marzia Puccioni-Sohler. "Difficulties in HAM/TSP diagnosis." Arquivos de Neuro-Psiquiatria 70, no. 9 (September 2012): 686–90. http://dx.doi.org/10.1590/s0004-282x2012000900007.

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The World Health Organization recommends the use of Osame's criterion (1990) for the diagnosis of HTLV-I-associated myelopathy (HAM/TSP). In 2006, a group of neurologists developed a Brazilian criterion that can diagnose HAM/TSP from its onset. OBJECTIVE: It was to test the agreement between both criteria. METHODS: The study included evaluation of clinical and laboratory findings of 35 patients. The ELISA, Western blot and/or polymerase chain reaction was used to search for anti-HTLV-I antibodies. The analysis of agreement was based on the calculation of Kappa. RESULTS: Concordance of 100% (Kappa=1) occurred in cases of "defined" HAM/TSP, but not in patients with "probable" diagnosis. CONCLUSION: The Brazilian criteria was as effective as Osame's criteria for the diagnosis of "defined" HAM/TSP. However, both require more specific biological markers in cerebrospinal fluid for the laboratory diagnosis of probable cases.
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34

Krylov, V. A., E. A. Azizov, V. N. Dokouka, R. R. Khayrutdinov, V. A. Korotkov, I. A. Kovan, Yu G. Krasikov, et al. "The tokamak TSP-AST concept." Fusion Engineering and Design 56-57 (October 2001): 825–29. http://dx.doi.org/10.1016/s0920-3796(01)00416-1.

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35

Di Guglielmo, Gianni M. "TSP-1 in lung fibrosis." Journal of Cell Communication and Signaling 4, no. 4 (September 23, 2010): 185–86. http://dx.doi.org/10.1007/s12079-010-0097-8.

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36

Hassin, Refael, and Shlomi Rubinstein. "Better approximations for max TSP." Information Processing Letters 75, no. 4 (September 2000): 181–86. http://dx.doi.org/10.1016/s0020-0190(00)00097-1.

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37

Abrahamson, Jeff, and Ali Shokoufandeh. "Euclidean TSP on two polygons." Theoretical Computer Science 411, no. 7-9 (February 2010): 1104–14. http://dx.doi.org/10.1016/j.tcs.2009.12.003.

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38

Jarrett, Jeffrey. "SYSTAT/SYGRAPH and Micro-TSP." Statistics and Computing 2, no. 4 (December 1992): 231–36. http://dx.doi.org/10.1007/bf01889683.

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39

Karpinski, Marek, Michael Lampis, and Richard Schmied. "New inapproximability bounds for TSP." Journal of Computer and System Sciences 81, no. 8 (December 2015): 1665–77. http://dx.doi.org/10.1016/j.jcss.2015.06.003.

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40

Zhangcan, Huang, and Lu Kuang. "A hybrid algorithm for TSP." Wuhan University Journal of Natural Sciences 1, no. 3-4 (December 1996): 461–64. http://dx.doi.org/10.1007/bf02900870.

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41

Liu, Zhiyu, Herong Shi, and Jun Liu. "The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function." PLOS Genetics 18, no. 1 (January 28, 2022): e1009936. http://dx.doi.org/10.1371/journal.pgen.1009936.

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Tetraspanin proteins are a unique family of highly conserved four-pass transmembrane proteins in metazoans. While much is known about their biochemical properties, the in vivo functions and distribution patterns of different tetraspanin proteins are less understood. Previous studies have shown that two paralogous tetraspanins that belong to the TspanC8 subfamily, TSP-12 and TSP-14, function redundantly to promote both Notch signaling and bone morphogenetic protein (BMP) signaling in C. elegans. TSP-14 has two isoforms, TSP-14A and TSP-14B, where TSP-14B has an additional 24 amino acids at its N-terminus compared to TSP-14A. By generating isoform specific knock-ins and knock-outs using CRISPR, we found that TSP-14A and TSP-14B share distinct as well as overlapping expression patterns and functions. While TSP-14A functions redundantly with TSP-12 to regulate body size and embryonic and vulva development, TSP-14B primarily functions redundantly with TSP-12 to regulate postembryonic mesoderm development. Importantly, TSP-14A and TSP-14B exhibit distinct subcellular localization patterns. TSP-14A is localized apically and on early and late endosomes. TSP-14B is localized to the basolateral cell membrane. We further identified a di-leucine motif within the N-terminal 24 amino acids of TSP-14B that serves as a basolateral membrane targeting sequence, and showed that the basolateral membrane localization of TSP-14B is important for its function. Our work highlights the diverse and intricate functions of TspanC8 tetraspanins in C. elegans, and demonstrates the importance of dissecting the functions of these important proteins in an intact living organism.
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42

王, 锦彪. "The Review of Backbone Algorithm about TSP." Computer Science and Application 03, no. 08 (2013): 374–80. http://dx.doi.org/10.12677/csa.2013.38065.

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43

Pimanda, John E., Douglas S. Annis, Mark Raftery, Deane F. Mosher, Colin N. Chesterman, and Philip J. Hogg. "The von Willebrand factor–reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974." Blood 100, no. 8 (October 15, 2002): 2832–38. http://dx.doi.org/10.1182/blood-2002-03-0770.

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Plasma von Willebrand factor (VWF) is a multimeric protein that mediates adhesion of platelets to sites of vascular injury; however, only the very large VWF multimers are effective in promoting platelet adhesion in flowing blood. The multimeric size of VWF can be controlled by the glycoprotein, thrombospondin-1 (TSP-1), which facilitates reduction of the disulfide bonds that hold VWF multimers together. The TSP family of extracellular glycoproteins consists of 5 members in vertebrates, TSP-1 through TSP-4 and TSP-5/COMP. TSP-1 and TSP-2 are structurally similar trimeric proteins composed of disulfide-linked 150-kDa monomers. Recombinant pieces of TSP-1 and TSP-2 incorporating combinations of domains that span the entire subunit were produced in insect cells and examined for VWF reductase activity. VWF reductase activity was present in the Ca++-binding repeats and C-terminal sequence of TSP-1, but not of TSP-2. Alkylation of Cys974 in the C-terminal TSP-1 construct, which is a serine in TSP-2, ablated VWF reductase activity. These results imply that the reductase function of TSP-1 centers around Cys974 in the C-terminal sequence.
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44

Capita, R., C. Alonso-Calleja, M. T. García Arias, B. Moreno, and M. C. García-Fernández. "Note. Effect of trisodium phosphate on mesophilic and psychrotrophic bacterial flora attached to the skin of chicken carcasses during refrigerated storage Nota. Efecto del fosfato trisódico en los microorganismos mesófilos y psicrotrofos presentes en la piel de canales de pollo durante su almacenamiento en refrigeración." Food Science and Technology International 6, no. 4 (August 2000): 345–50. http://dx.doi.org/10.1177/108201320000600410.

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The potential for using trisodium phosphate (TSP) to reduce mesophilic and psychrotrophic popula tions on the skin of chicken carcasses was explored. Skin samples were immersed in sterile tap water (control) or an 8%, 10% or 12% solution of TSP at 20 °C for 15 min. Surface pH values and mesophilic and psychrotrophic plate counts were determined after 0, 1, 3 and 5 days of storage at 2° C. After washing, bacterial populations were significantly smaller in the samples treated with TSP than in the controls. The concentration of the TSP solution was a significant factor in reducing the populations of the bacteria on chicken skin. Before storage, the reduction in the presence of bacteria achieved in treated samples with respect to controls ranged between 0.95 log10 cycles and 1.78 log10 cycles in the case of mesophilic microorganisms, and 0.92 log10 cycles and 1.94 log10 cycles in the case of psychrotrophic strains. These differences between the concentrations of bacteria in samples immersed in water and those treated with TSP increased over time, ranging from 2.35 log 10 cycles to 3.08 log10 cycles (mesophilic microorganisms), and from 2.79 log10 cycles to 4.09 log10 cycles (psychrotrophic microorganisms) on day 5 of storage. The pH of the skin remained more or less constant throughout the study period, ranging between 8 and 9 in skin treated with TSP, depending on the concentration, while it was two units lower in the control samples.
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45

Murphy-Ullrich, J. E., S. Schultz-Cherry, and M. Höök. "Transforming growth factor-beta complexes with thrombospondin." Molecular Biology of the Cell 3, no. 2 (February 1992): 181–88. http://dx.doi.org/10.1091/mbc.3.2.181.

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Thrombospondin (TSP) was demonstrated to inhibit the growth of bovine aortic endothelial cells, an activity that was not neutralized by antibodies to TSP or by other agents that block TSP-cell interactions but that partially was reversed by a neutralizing antibody to transforming growth factor-beta (TGF-beta). Similar to TGF-beta, TSP supported the growth of NRK-49F colonies in soft agar in a dose-dependent manner, which required epidermal growth factor and was neutralized by anti-TGF-beta antibody. Chromatography of a TSP preparation did not separate the TGF-beta-like NRK colony-forming activity from high molecular weight protein. However, when chromatography was performed at pH 11, this activity was dissociated from TSP. These results suggest that at least some growth modulating activities of TSP are due to TGF-beta associated with TSP by strong non-covalent forces. Most of the active TGF-beta released from platelets after degranulation was associated with TSP, as demonstrated by anti-TSP immunoaffinity and gel permeation chromatography. 125I-TGF-beta binds to purified TSP in an interaction that is specific in the sense that bound TGF-beta could be displaced by TGF-depleted TSP but not significantly by native TSP, heparin, decorin, alpha 2-macroglobulin, fibronectin, or albumin. Hence, TGF-beta can bind to TSP, and the complex forms under physiological conditions. Furthermore, TSP-associated TGF-beta is biologically active, and the binding of TGF-beta to TSP may protect TGF-beta from extracellular inactivators.
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46

DROR, MOSHE, YUSIN LEE, JAMES B. ORLIN, and VALENTIN POLISHCHUK. "THE TSP AND THE SUM OF ITS MARGINAL VALUES." International Journal of Computational Geometry & Applications 16, no. 04 (August 2006): 333–43. http://dx.doi.org/10.1142/s0218195906002063.

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This paper introduces a new notion related to the traveling salesperson problem (TSP) — the notion of the TSP ratio. The TSP ratio of a TSP instance I is the sum of the marginal values of the nodes of I divided by the length of the optimal TSP tour on I, where the marginal value of a node i ∈ I is the difference between the length of the optimal tour on I and the length of the optimal tour on I\i. We consider the problem of establishing exact upper and lower bounds on the TSP ratio. To our knowledge, this problem has not been studied previously. We present a number of cases for which the ratio is never greater than 1. We establish a tight upper bound of 2 on the TSP ratio of any metric TSP. For the TSP on six nodes, we determine the maximum ratio of 1.5 in general, 1.2 for the case of metric TSP, and 10/9 for the geometric TSP in the L1 metric. We also compute the TSP ratio experimentally for a large number of random TSP instances on small number of points.
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47

Knaapen, A. M., G. J. den Hartog, A. Bast, and P. JA Borm. "Ambient particulate matter induces relaxation of rat aortic rings in vitro." Human & Experimental Toxicology 20, no. 5 (May 2001): 259–65. http://dx.doi.org/10.1191/096032701678227677.

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Epidemiological studies have shown an association between ambient levels of particulate matter (PM) and increased mortality from cardiovascular diseases. However, the underlying mechanisms are still not clear. We hypothesised that PM, when translocated after inhalation, could affect vascular smooth muscle function. Therefore, total suspended particulate matter (TSP) was sampled and investigated for its ability to affect aortic muscle contraction. Both TSP and TSP supernatant (TSP-sup) induced a concentration-dependent relaxation of phenylephrine (PE)-precontracted aortic rings. Relaxation induced by 100 jg/ml TSP was 51.5 t 3.1% of total contraction. At 60 and 100 Hg/ ml, relaxation induced by TSP was significantly higher compared to TSP-sup. Ultrafine TiO2, used as a model to investigate the role of ultrafine particles, did not show an effect. Soluble iron, present in TSP suspensions, seems not to be involved, as chelating with deferoxamine did not affect TSP-induced relaxation. However, TSP effects were inhibited by Trolox, suggesting a role of oxidants. Nudation of aortic rings showed that effects of TSP were only partly endothelium-dependent, while preincubation with LNAME increased TSP-induced relaxation. From these data, we conclude that both the particle core and soluble components of TSP can affect the smooth muscle function, leading to changes in the vascular contractile response.
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48

Cerron-Vela, Carmen Rosa, Percy Moreno Navarro, and William J. Araujo-Banchon. "Características tomográficas del tumor sólido pseudopapilar de páncreas (tumor de Frantz)." Revista de la Facultad de Ciencias Médicas de Córdoba 77, no. 1 (March 16, 2020): 33–38. http://dx.doi.org/10.31053/1853.0605.v77.n1.26228.

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Introducción: El tumor sólido pseudopilar de páncreas (TSP), o tumor de Frantz, es una neoplasia rara de bajo grado que acontece principalmente en mujeres jóvenes. Fue descrita en 1959 por Virginia Frantz y constituye del 0.2-2.7% de todos los tumores pancreáticos. La tomografía computada (TC) desempeña un papel importante en el diagnóstico de esta patología de escaso reporte. El objetivo del presente estudio es describir las características epidemiológicas y tomográficas del TSP en el Instituto Nacional de Enfermedades Neoplásicas (INEN) del Perú. Métodos: Estudio transversal descriptivo realizado con historias clínicas (HC) de todos los pacientes con diagnóstico de TSP entre los años 2004 y 2014. Las variables descritas fueron tamaño del tumor, ubicación, forma, bordes, grosor de la cápsula, composición, calcificaciones y captación de contraste. Las variables categóricas fueron expresadas en frecuencias absolutas y relativas; mientras que las variables numéricas fueron descritas con mediana y desviación intercuartílica (DIC). Se utilizó como soporte estadístico STATA Versión 12.0. Resultados: De todos los tumores quísticos de páncreas (TQP), el 51.9 % correspondió a casos confirmados de TSP. La mediana de la edad fue 23.5 años. Predominó la ubicación aislada en cabeza (33.3 %); la ubicación mixta más frecuente fue la de cuerpo y cola (16.7 %); fue más frecuente el diámetro entre 5.1-10 cm y el contenido de la mayoría fue a predominio sólido. El 30.0 % de los TSP presentaron calcificaciones. Conclusión principal: La mayoría casos de TSP del INEN (2004-2014) tienen características similares a lo reportado en la literatura internacional.
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49

Nicosia, RF, and GP Tuszynski. "Matrix-bound thrombospondin promotes angiogenesis in vitro." Journal of Cell Biology 124, no. 1 (January 1, 1994): 183–93. http://dx.doi.org/10.1083/jcb.124.1.183.

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Thrombospondin (TSP) is a multidomain adhesive protein postulated to play an important role in the biological activity of the extracellular matrix. To test this hypothesis, TSP-containing fibrin and collagen matrices were evaluated for their capacity to support angiogenesis and cell growth from explants of rat aorta. This serum-free model allowed us to study the angiogenic effect of TSP without the interference of attachment and growth factors present in serum. TSP promoted dose-dependent growth of microvessels and fibroblast-like cells. The number of microvessels in TSP-containing collagen and fibrin gels increased by 136 and 94%, respectively. The TSP effect was due in part to cell proliferation since a 97% increase in [3H]thymidine incorporation by the aortic culture was observed. The effect was TSP-specific because TSP preparations adsorbed with anti-TSP antibody showed no activity. TSP did not promote angiogenesis directly since no TSP-dependent growth of isolated endothelial cells could be demonstrated. Rather TSP directly stimulated the growth of aortic culture-derived myofibroblasts which in turn promoted microvessel formation when cocultured with the aortic explants. Angiogenesis was also stimulated by myofibroblast-conditioned medium. Partial characterization of the conditioned medium suggests that the angiogenic activity is due to heparin-binding protein(s) with molecular weight &gt; 30 kD. These results indicate that matrix-bound TSP can indirectly promote microvessel formation through growth-promoting effects on myofibroblasts and that TSP may be an important stimulator of angiogenesis and wound healing in vivo.
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50

Ko, Hee-Jung, Chang-Hee Kang, Won-Hyung Kim, Soon-Bong Lee, and Hwa-Suk Kang. "Long-term Variation of Ionic Constituent Concentrations in TSP at Jeju Island." Journal of Korean Society for Atmospheric Environment 26, no. 4 (August 31, 2010): 420–31. http://dx.doi.org/10.5572/kosae.2010.26.4.420.

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