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Dissertations / Theses on the topic 'TRPV1'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Hering, Nils [Verfasser]. "Elektrophysiologische Charakterisierung der Ionenkanäle TRPV1, TRPV3 und TRPV4 exprimiert in Xenopus Oozyten. / Nils Hering." Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/1096220881/34.

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2

Hasan, S. M. Raquibul. "Modulation of the TRPA1 and TRPV1 ion channels." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708079.

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3

Hellwig, Nicole. "Protonenleitfähigkeit von TRPV1 und Multimerisierung von TRPV-Kanaluntereinheiten." [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2005/177/index.html.

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4

Sinha, Sayantani. "Role of TRPA1 and TRPV1 in Propofol Induced Vasodilation." Thesis, Kent State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3618926.

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<p> <b>Aims:</b> Propofol, clinically named as Diprivan is an intravenous anesthetic known to cause hypotension in patients presenting for surgery. We have investigated the vasodilatory signaling cascade by which propofol causes hypotension using both <i>in vivo</i> and <i>in vitro </i> experimental approaches. </p><p> <b>Methods and Results:</b> Using high-fidelity microtip transducer catheter, mean arterial blood pressure (MAP) was measured in control, transient receptor potential ankyrin subtype 1 knock-out (TRPA1<sup>-/-</sup>), transient receptor potential vanilloid 1 knock-out (TRPV1<s
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5

SINHA, SAYANTANI. "Role of TRPA1 and TRPV1 in Propofol Induced Vasodilation." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1384901930.

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6

Sprague, Jared Michael. "TRPV1 Sensitization in Primary Sensory Neurons." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11441.

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Pain is a major personal and community burden throughout the world with currently limited treatment options for persistent pain due to unacceptable side effects, dependence or frank inefficacy. It is necessary to understand the anatomical and molecular pathways leading to pain to better cope with the current challenge of treating it.
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7

O'Leary, Caitriona. "The role of TRPV1 and TRPV4 channels in retinal angiogenesis." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709849.

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Abnormal angiogenesis is a key pathological process associated with many diseases such as metastatic cancer, atherosclerosis, and sight-threatening disorders including proliferative diabetic retinopathy, neovascular age-related macular degeneration, and retinopathy of prematurity. Calcium signalling is fundamental for many endothelial functions including the regulation of blood vessel tone, barrier selectivity and angiogenesis. Calcium influx has been implicated in retinal endothelial cell angiogenic response, but the molecular identity of the underlying calcium channels remains to be fully el
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8

Sinharoy, Pritam. "Cross Talk Between TRPA1 and TRPV1 Ion-Channels: Role of Nitric Oxide." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1467381679.

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9

Chen, Lan [Verfasser]. "Functional TRPV1 and TRPV4 channels in the murine renal vasculature / Lan Chen." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148425926/34.

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10

SUGIHARA, YASUO, MINORU UEDA, HIDEYUKI NAKASHIMA, et al. "INVOLVEMENT OF GLIAL ACTIVATION IN TRIGEMINAL GANGLION IN A RAT MODEL OF LOWER GINGIVAL CANCER PAIN." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/20551.

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11

Fernandes, Maria Antionetta. "An investigation of the roles of TRPV1, TRPA1 and hydrogen sulfide in thermoregulation." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/an-investigation-of-the-roles-of-trpv1-trpa1-and-hydrogen-sulfide-in-thermoregulation(811086d3-46c1-4f3f-9288-131bebf36431).html.

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The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is an integrator of noxious stimuli, including noxious heat ( > 43°C), low pH ( < 6) and capsaicin (the pungent component of chilli peppers). Transient Receptor Potential Ankyrin 1 (TRPA1) is a closely related channel, activated by reactive oxygen species, hydrogen sulfide (H2S) and mustard oil. Their expression on primary sensory neurons is well characterised. Recent studies show that they are also expressed in non‐neuronal tissue. Whilst TRPV1 and TRPA1 antagonism is a promising analgesic and anti‐inflammatory strategy, early g
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12

Grace, Megan Stacey. "Investigating the role of TRPA1 and TRPV1 ion channels in the cough reflex." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/14571.

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Cough is under the control of sensory afferents which innervate the airways via the vagus nerve. Cough is an important protective reflex that clears the airway, but can become exacerbated and deleterious when associated with airways diseases, in which there is enhanced release of inflammatory mediators and a decrease in lung pH. These mediators sensitise airway afferents and could be driving enhanced cough associated with inflammation. Transient Receptor Potential (TRP) ion channels are associated with several disease pathologies. TRPV1 has an established role in cough, and is implicated in th
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13

Colton, Craig K. "TRPV3 is a polymodal receptor." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164046830.

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14

EL, Andaloussi-Lilja Johanna. "Activation and regulation of TRPV1 : studies in recombinant human neuroblastoma TRPV1-SHSY5Y cells /." Stockholm : Department of Neurochemistry, Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-30182.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2009.<br>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: In press. Paper 4: In press. Härtill 4 uppsatser.
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15

Cao, Deshou. "Role of Transient Receptor Potential (TRP) Channels in Nociception." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/dissertations/71.

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Transient receptor potential (TRP) channels play an important role in sensory and nonsensory functions. TRPVanilloid 1 and TRPVanilloid 4 are proposed to be involved in inflammation-induced pain. TRPV1 is extensively studied and it is specifically involved in inflammatory thermal hypersensitivity. Mechanical hypersensitivity is one of the significant components of nociception. Several receptors have been proposed to underlie mechanosensation. The molecular entities responsible for mechanosensation are not fully understood. In this study, I have characterized the properties of TRPV4, a putative
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16

Ibarra, Yessenia Michelle. "Characterization of human TRPA1 and TRPV1 channels in response to naturally occurring defensive compounds." Thesis, Harvard University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3566933.

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<p> The transient receptor potential channels, ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1), are non-selective cation-permeable channels that have retained their function as chemical sensors since their first appearance in metazoan species several hundred million years ago. In vertebrates, TRP channels have evolved multiple functions which make it difficult to understand exactly how they transmit signals to the brain that are interpreted very differently. For example, TRPA1 and TRPV1 are sensitive to various chemicals and activation of these channels produce sensations with opposing effects. Pain
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17

DEMARTINI, CHIARA. "The role of TRPA1 and TRPV1 channels in trigeminal pain: data from animal models." Doctoral thesis, Università degli studi di Pavia, 2018. http://hdl.handle.net/11571/1214824.

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Experimental and clinical observations pointed out a critical involvement of transient receptor potential (TRP) channels, particularly TRPA1 and TRPV1, in trigeminal pain and associated symptoms, including hyperalgesia and allodynia. In this study the role of TRP channels was investigate in two animal models of diseases related to the trigeminal system: migraine and trigeminal neuropathic pain (TNP). TRPA1 and TRPV1 antagonists (ADM_12 and AMG9810 respectively) were used in the nitroglycerin (NTG)-induced hyperalgesia at the trigeminal level induced by means of the orofacial formalin test, a
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18

Leonelli, Mauro. "Receptores vanilóides TRPV1 na retina." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-22072011-131242/.

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A expressão do receptor de potencial receptor transiente, vanilóide 1 (TRPV1) começa desde estágios pré-sinaptogênicos da retina. O bloqueio farmacológico desse receptor nesse período diminui a apoptose fisiológica, havendo possível envolvimento da sinalização de MAP quinases. Na retina do animal adulto, observamos que a expressão de TRPV1 é amplamente difundida, albergando neurônios, células endoteliais e células da microglia. A ativação dos receptores TRPV1 é potencialmente citotóxica, e os mecanismos que podem estar envolvidos incluem a liberação de glutamato, a excitotoxicidade e o estress
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19

Goswami, Chandan. "Identification of tubulin as a TRPV1-interacting protein and functional characterization of TRPV1-cytoskeleton regulation." [S.l.] : [s.n.], 2006. http://www.diss.fu-berlin.de/2006/315/index.html.

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20

Rosano, Giulio. "Structure-function studies of TRPV1 alcohol modulation." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19298/.

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The TRPV1 channel is a member of the Transient Receptor Potential (TRP) family of cation channels and is responsible for the perception of different noxious stimuli. It is mainly found in the peripheral terminals of primary sensory neurons where pain is produced and in various brain regions such as hypothalamus, cerebellum and cerebralcortex. It can be activated by a large number of physical and chemical stimuli and themost known ones include capsaicin (the active component of hot chili peppers), noxiousheat (greater than 42◦C), voltage and acidity. There is now evi
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21

Schwarz, Holger Jens [Verfasser], and Bela [Akademischer Betreuer] Szabo. "Die Rolle des TRPV1-Rezeptors im Cerebellumcortex." Freiburg : Universität, 2016. http://d-nb.info/1119806062/34.

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22

Pritchard, Sara. "Modulation of TRPV1 function in sensory neuropathy." Thesis, University of Hertfordshire, 2015. http://hdl.handle.net/2299/15360.

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This thesis examined how and why TRPV1 function is being modulated in sensory neuropathy and explored the potential of its rescue in the urinary bladder of STZ-­‐induced diabetic rats. Diabetes induced a rapid decline in TRPV1 function and changes in neurogenically mediated electrically-­‐evoked responses together with a gradual decline in muscarinic function. Diabetic bladder was also deficient in muscarinic and TRPV1 organ bath temperature-­‐induced changes but not in those affecting spontaneous contractile activity. Exposure to a potential neuropathy causative agent, methylglyoxal was studi
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23

Saffran, Alexander. "Activation of TRPV1 by Capsaicin Regulates ENaC." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5544.

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ENaC is a constitutively open heterotrimeric channel which regulates Na+ transport in tight epithelia of the kidney, lungs, colon and anterior tongue containing fungiform taste buds. The amiloride-sensitive ENaC is comprised of aβg subunits. Humans express an additional subunit, the d subunit. Therefore, humans contain both aβg-ENaC and dβg-ENaC functional channels. Relative to aβg-ENaC, the dβg-ENaC is 10-fold less sensitive to amiloride. In the mammalian anterior tongue, ENaC is expressed in fungiform salt sensing taste receptor cells and is the Na+-specific salt taste receptor. In mammals,
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24

Hadrovic, Banina. "A study of TRPV1 and TRPV4 ion channels in the beta cells by using fura-2 based microfluorometry." Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-7350.

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<p>The calcium ion (Ca<sup>2+</sup>) is an important ion that regulates many cellular functions including exocytosis, contraction of muscles, neural functions, fertilization and cell division. In the plasma membrane of cells there are different Ca<sup>2+</sup> channels, including the transient receptor potential (TRP) family of cation channels. The TRP channels are activated by physical stimuli like temperature, stretch, osmolality, and also various ligands. These channels are divided into seven subfamilies, namely TRPC, TRPV, TRPM, TRPML, TRPA, TRPP, and TRPN.</p><p> </p><p>TRP channels can r
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25

Niedermirtl, Florian [Verfasser], and Carla [Akademischer Betreuer] Nau. "Das intravenöse Anästhetikum Propofol aktiviert nozizeptive Neurone über TRPA1-, TRPV1- und GABAA-Rezeptoren / Florian Niedermirtl. Betreuer: Carla Nau." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2011. http://d-nb.info/1018309101/34.

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26

Wong, Benjamin. "Functional roles of different TRPV1 populations in calcium signalling of rat sensory neurons and HEK 293 cells expressing rat TRPV1." Thesis, University of Hertfordshire, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632998.

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The TRPV1 vanilloid receptor is thought to be expressed on both plasmalemmal (TRPV1PM) and intracellular (TRPV1ER) membranes. Membrane-impermeable TRPV1PM restricted antagonists (SB-497794-D and ruthenium red) were used to investigate the functional roles of TRPV1PM and TRPV1ER in capsaicin-activated calcium signalling of TRPV1-expressing cells (rat DRG neurons and rat TRPV1-expressing HEK 293 cells). The ability of TRPV1PM restricted antagonists to completely block capsaicin activation of TRPV1PM when TRPV1-expressing cells were challenged with capsaicin enabled the remaining capsaicin-activa
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27

Leffler, Andreas. "TRPV1 ist ein polymodaler Rezeptor von nozizeptiven Spinalganglienzellen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972880216.

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28

Hanack, Christina [Verfasser]. "Proteomics reveal insights into TRPV1 function / Christina Hanack." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1050978390/34.

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29

Païta, Lucille. "Caractérisation du canal cationique TRPV1 dans les cardiomyocytes." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1329/document.

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L'infarctus du myocarde, une des causes majeures de mortalité à travers le monde, engendre une mort irréversible du muscle cardiaque suite à une ischémie. Cette ischémie, c'est-à-dire une privation de dioxygène et de nutriments, déclencher un stress réticulaire qui perturbe l'équilibre calcique de la cellule cardiaque. Plusieurs pompes et canaux calciques situés à la membrane plasmique ou réticulaire sont des intervenants clés dans le maintien de l'homéostasie calcique. Parmi eux, il existe des canaux de fuites calciques passives, comme les TRPs, et peu d'informations sont actuellement connus
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30

Jorge, Carolina Ocanha 1990. "Envolvimento dos receptores TRPV1 e TRPA1 na hiperalgesia muscular induzida pela contração isométrica sustentada no músculo gastrocnêmio de ratos." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/244490.

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Orientadores: Maria Cláudia Gonçalves de Oliveira Fusaro, Andrea Maculano Esteves<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas<br>Made available in DSpace on 2018-08-27T04:11:06Z (GMT). No. of bitstreams: 1 Jorge_CarolinaOcanha_M.pdf: 1325403 bytes, checksum: 6635807ae28ce8dbb49ec5d1bcc74a75 (MD5) Previous issue date: 2015<br>Resumo: A dor musculoesquelética é um importante problema de saúde mundial. Dentre todos os tipos de dor, àquela induzida pela contração isométrica sustentada está relacionada com os movimentos corporais nas atividades d
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31

Gu, C. "Signalling pathways underlying sensitization of TRPV1 by RET receptors." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599771.

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Here I report that artemin, a member of the glial cell line-derived neurontrophic factor (GDNF) family, can potentiate TRPV1 activity. Analysis of capsaicin-evoked Ca<sup>2+</sup> transients in isolated mouse dorsal root ganglion (DRG) neurons and neuro-2a cells revealed a rapid, potent and prolonged sensitization caused by artemin (~60% cells sensitized with ~2-fold increase in peak response to capsaicin). The mechanism of sensitization of TRPV1 by artemin was further investigated by observing the effects of inhibitors of potential members of artemin-activated second messenger signalling path
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32

CABRAL, Layla Dutra Marinho. "Influência do receptor vanilóide tipo 1 (TRPV1) na endotoxemia." Universidade Federal de Alfenas, 2016. https://bdtd.unifal-mg.edu.br:8443/handle/tede/997.

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A presença de endotoxina bacteriana na corrente circulatória é associada ao início e manutenção da sepse, condição complexa e heterogênea que promove a liberação de mediadores inflamatórios, os quais conduzem a alterações no sistema nervoso central e subsequente resposta imunológica inflamatória desequilibrada, com desencadeamento da síndrome da disfunção de múltiplos órgãos (SDMO). Os receptores TRPV1, por sua vez, participam da modulação de diversos sistemas e podem influenciar processos fisiológicos comprometidos por inflamação, representando potencial alvo terapêutico. O objetivo do
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33

Rossato, Mateus Fortes. "Eriodictiol: um flavonóide antagonista do receptor trpv1 com atividade antioxidante." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/11134.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The transient receptor potential vanilloid 1 (TRPV1) is a calcium permeable channel responsible for the transduction and modulation of acute and chronic pain signaling, being a potential target for treatment of different pain disorders. In spite of that, AMG517, a TRPV1 antagonist, presents several clinical limitations, such as the development of severe hypertermia. The aim of this study was to investigate the possible interaction of the flavonoid eriodictyol with the TRPV1 receptor and its putative antinociceptive and hypertherm
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34

Kiasalary, Reineh Zahra. "Anatomical and functional studies on TRPV1- expressing primary sensory neurons." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420426.

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35

Sadofsky, Laura Rachel. "Molecular pharmacology of the capsaicin receptor (TRPV1) in the airways." Thesis, University of Hull, 2005. http://hydra.hull.ac.uk/resources/hull:8630.

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The capsaicin receptor (vanilloid receptor I, transient receptor potential vanilloid 1 or TRPV I) is a member of the transient receptor potential (TRP) family of proteins. This cation channel is sensitive to a range of inflammatory mediators such as some lipoxygenase products, as well as the tussive agents capsaicin, resiniferatoxin and protons. It has been proposed that TRPV I is a cough receptor and may be important in airways inflammation. Rat TRPVI (rTRPVI) and human TRPVI (hTRPVl) permanently expressing cell lines were generated and successfully characterised by agonist triggered changes
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36

Bhattacharjee, Anupam. "The biophysics and pharmacology of native and recombinant TRPV1 receptors." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409218.

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37

Paule, Cleoper. "Molecular bases underlying the sensitivity of the capsaicin receptor TRPV1." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6144.

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Individual human beings report highly variable pain experiences following exposure to the same noxious stimulus, including noxious heat. A series of missense single nucleotide polymorphisms (SNPs) have been found in the human noxious heat transducer, transient receptor potential vanilloid type 1 ion channel (hTRPV1), which responds to, exogenous, and endogenous, vanilloids, protons, and depolarisation. The aim of this project was to examine the effect of SNPs on the sensitivity of hTRPV1 to certain activators. The three most frequently occurring SNPs (I315M, T469I, V585I) were used to generate
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Saunders, Cecil James. "The respiratory response of Trpv1 knockout mice to trigeminal irritants." Winston-Salem, NC : Wake Forest University, 2008. http://dspace.zsr.wfu.edu/jspui/handle/10339/37483.

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Tessier, Nolwenn. "Rôle du canal calcique TRPV1 dans l’ischémie-reperfusion du myocarde." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1165.

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Au cours de l’infarctus du myocarde, aussi bien l’ischémie que la reperfusion (I/R) entrainent des dégâts irréversibles au sein du myocarde. Parmi ces lésions cellulaires, la dérégulation de l’homéostasie calcique mène à la mort cellulaire. Afin d’augmenter la récupération suite à un épisode d’I/R, le « remote », pré- et post-conditionnement ont été montré comme cardioprotecteur. En particulier, certaines stratégies basées sur des molécules pharmacologiques modulant les canaux TRPV1 (Transient Receptor Vanilloid 1) ont été utilisées. Le but de cette étude est de comprendre le rôle de TRPV1 dan
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Hua, Pierce. "Characterization of a novel pre-pore loop antibody against rat TRPV1." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111948.

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Splice variants of the transient receptor potential vanilloid type-1 (TRPV1) channel appear to be involved in the physiological detection of extracellular fluid (ECF) osmolality in the supraoptic nucleus (SON) and organum vasculosum lamina terminalis (OVLT). It remains to be determined whether these splice variants are directly involved as pore-forming proteins in the osmosensory transduction complex. Since these TRPV1 splice variants are not sensitive to capsaicin antagonists, such as capsazepine (Sharif Naeini et al., 2007), novel tools that specifically interfere with ion permeation through
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Sharif, Naeini Reza. "Contribution of the Trpv1 gene to the physiology of supraoptic neurons." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111867.

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The release of vasopressin (VP) from magnocellular neurosecretory cells (MNCs) of the supraoptic (SON) and paraventricular (PVN) nuclei is essential to hydromineral homeostasis. This release is controlled by several physiological stimuli, including changes in the osmotic pressure of the extracellular fluid, and in core body temperature. The osmotic control of VP release is mediated by specific and highly sensitive 'osmoreceptors'. Indeed, VP-releasing neurons in the SON are directly osmosensitive, and this osmosensitivity is mediated by stretch-inhibited cation channels. The molecular identity
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42

Kasper, Christian [Verfasser]. "Die Modulation des TRPV1 Kanals durch das Adapterprotein ARMS / Christian Kasper." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1160514763/34.

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43

Bonacin, Yuri da Silva. "Expressão e quantificação de receptores vanilóides TRPV1 na dermatite digital bovina /." Jaboticabal, 2017. http://hdl.handle.net/11449/150352.

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Orientador: José Antonio Marques<br>Coorientador: Sérgio Britto Garcia<br>Banca: Deborah Penteado Martins Dias<br>Banca: Paulo Aléscio Canola<br>Resumo: A Dermatite Digital Bovina (DDB) constitui uma das principais causas de graus elevados de claudicação em bovinos leiteiros, em função da dor que estes animais aparentam frente ao estímulo nocioceptivo. A hiperalgesia em alguns casos de dor crônica está relacionada à expressão exacerbada de fibras dos receptores vaniloides TRPV1, podendo haver forte correlação com casos crônicos da DDB. No presente estudo foram utilizados 15 bovinos, fêmeas, da
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Mak, Stephanie Wai Yin. "Modulation of temperature sensitive ion channels TRPV1 and TRPM8 by Bradykinin." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611520.

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45

Santos, Fabio Martinez dos. "Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-05102015-150313/.

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A técnica de Mobilização Neural (MOB) é um método não invasivo que demonstrou tanto na pesquisa básica, como na pesquisa clinica ser eficaz na redução da sensibilidade à dor. O presente, estudo visa examinar os efeitos da MOB na disfunção locomotora, na força muscular, nas alterações morfológicas no nervo isquiático e nas alterações moleculares induzida pela constrição crônica (CCI) do nervo isquiático de ratos Wistar. Para analisar a disfunção locomotora utilizamos o índice funcional do nervo Isquiático (IFC). Para analisar a força muscular, o sistema Biopac System. A ultraestrutura do nervo
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46

JÃnior, Roberto CÃsar Pereira Lima. "Antinociceptive effect of the mixture of pentacyclic triterpenes alpha- and beta- amyrin in models of visceral nociception in mice." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Protium heptaphyllum March (Burseraceae), a medicinal plant commonly found in the Amazon and in the Northeast regions of Brazil, releases an oil-resin rich in pentacyclic triterpenes, such as the binary mixture of alpha- and beta- amyrin, that manifests antiinflamatory, antinociceptive and gastroprotective properties. This work was aimed to evaluate the antinociceptive effect of the alpha- and beta- amyrin mixture in the cyclophosphamide (400 mg/kg), acetic acid (0,6%, 10mL/kg, i.p.) and mustard oil-induced visceral nociception mod
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47

Dias, MarÃlia Leite. "Atividade antinociceptiva da riparina IV: participaÃÃo dos receptores TRPV1, TRPM8, receptores glutamatÃrgicos e do Ãxido nÃtrico." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8632.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A Riparina IV, uma alcamida sintetizada de Aniba riparia, foi testada em modelos animais padronizados de dor, bem como os possÃveis mecanismos de aÃÃo envolvidos. Foram utilizados camundongos Swiss (20-30g), e a Riparina IV foi administrada de forma aguda em todos os testes, nas doses de 25 e 50 mg/kg, por via oral. Foram utilizados os testes de contorÃÃes abdominais induzidas por Ãcido acÃtico; placa quente; teste da formalina; hipernocicepÃÃo mecÃnica induzida pela carragenina; teste da nocicepÃÃo induzida por capsaicina, cinamal
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48

Zhou, Bolu. "Activation Of Trpv1 Channel Contributes To Serotonin-Induced Constriction Of Mouse Facial Artery." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/754.

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Tight regulation of cephalic blood circulation is critical under normal physiological conditions, and dysregulation of blood flow to the head occurs in pathophysiological situations such as stroke and migraine headache. The facial artery is an extracranial artery which is one of branches from the external carotid artery territory and its extracranial position indicates its importance in regulating head hemodynamics. Transient receptor potential vanniloid type 1 (TRPV1) is a cation channel permeable to Ca2+ and Na+. Intracellular Ca2+ increase causes vasoconstriction. A previous study indicated
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49

Vidal, Mosquera Miguel. "Chemical modulation of the nociceptive receptor TRPV1: Synthetic, biological and computational studies." Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/369846.

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El canal iònic Receptor Vanil·loide Tipus 1 (sigles en anglès TRPV1) es considera un important integrador de diverses senyals de dolor. D'entre tots els productes que interaccionen amb TRPV1, aquells que bloquegen el senyal doloros de forma no competitiva han atret l'interès dels investigadors que treballen en el camp. A partir de resultats prèviament obtinguts per a diversos peptoides que van mostrar activitat com antagonistes no competitius de TRPV1 i que van permetre proposar una senzilla hipòtesi farmacoforica que incloïa un grup catiònic i dos aromàtics idèntics, la present tesi es va cen
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Hoffmeister, Carin Gorete Hendges. "PAPEL DO TRPV1 EM UM MODELO ARTICULAR DE GOTA AGUDA EM RATOS." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/3838.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The gout is an extremely painful type of arthritis. Despite the large number of drugs available for its treatment, they usually cause many adverse effects that limit their use. Then, further investigations are necessary for a better understanding the different mechanisms involved in gout. It was found previously that TRPV1 receptor, an ion channel modulated by various inflammatory mediators mediated edema and the nociceptive responses induced by subcutaneous injection of MSU in rats. In this plantar model, activation of TRPV1 dep
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