Relevant bibliographies by topics / Triple T

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Academic literature on the topic 'Triple T'

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Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Triple T"

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Kunkler, Charlotte N., Jacob P. Hulewicz, Sarah C. Hickman, Matthew C. Wang, Phillip J. McCown, and Jessica A. Brown. "Stability of an RNA•DNA–DNA triple helix depends on base triplet composition and length of the RNA third strand." Nucleic Acids Research 47, no. 14 (July 2, 2019): 7213–22. http://dx.doi.org/10.1093/nar/gkz573.

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AbstractRecent studies suggest noncoding RNAs interact with genomic DNA, forming an RNA•DNA–DNA triple helix that regulates gene expression. However, base triplet composition of pyrimidine motif RNA•DNA–DNA triple helices is not well understood beyond the canonical U•A–T and C•G–C base triplets. Using native gel-shift assays, the relative stability of 16 different base triplets at a single position, Z•X–Y (where Z = C, U, A, G and X–Y = A–T, G–C, T–A, C–G), in an RNA•DNA–DNA triple helix was determined. The canonical U•A–T and C•G–C base triplets were the most stable, while three non-canonical base triplets completely disrupted triple-helix formation. We further show that our RNA•DNA–DNA triple helix can tolerate up to two consecutive non-canonical A•G–C base triplets. Additionally, the RNA third strand must be at least 19 nucleotides to form an RNA•DNA–DNA triple helix but increasing the length to 27 nucleotides does not increase stability. The relative stability of 16 different base triplets in DNA•DNA–DNA and RNA•RNA–RNA triple helices was distinctly different from those in RNA•DNA–DNA triple helices, showing that base triplet stability depends on strand composition being DNA and/or RNA. Multiple factors influence the stability of triple helices, emphasizing the importance of experimentally validating formation of computationally predicted triple helices.
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Wjst, Matthias. "The Triple T Allergy Hypothesis." Clinical and Developmental Immunology 11, no. 2 (2004): 175–80. http://dx.doi.org/10.1080/10446670410001722258.

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The early induction of allergy is a complex process involving protective and destructive gene variants, environmental and nutritional co-factors as well as allergen exposure. Although critical doses, interactions and susceptible time frames have not been identified so far, late gestation and early childhood seem to be important time periods for allergic sensitization.At least three risk factors can be distinguished based on altered early Th1 lymphocyte development. First, the number of children with an inborn maturation defect may have increased since the beginning of the last century, when this condition would otherwise have had a lethal outcome without antibiotics and other modern health care (survival hypothesis). Second, another group of children in industrialized countries may have a deficit of environmental Th1 triggers during early life (hygiene hypothesis). A third factor may also be found predominantly in western societies. The prophylaxis of rickets with vitamin D has the apparent side effect of suppressing Th1 development (vitamin hypothesis).Experimental as well as epidemiological studies now provide evidence for the vitamin hypothesis, which is examined in this paper by a time-course analysis of vitamin D application in Germany. Also paper studies in Swedish anthroposophic school children, the Tristan da Cunha islanders, and Swiss, Austrian and Bavarian farmers may be linked to either excessive or absent early vitamin D exposure.
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Lin, Jie, Yan Wang, and Shaoqiang Deng. "T∗-extension of Lie triple systems." Linear Algebra and its Applications 431, no. 11 (November 2009): 2071–83. http://dx.doi.org/10.1016/j.laa.2009.07.001.

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Zhou, Jia, Liangyun Chen, and Yao Ma. "Generalized derivations of Lie triple systems." Open Mathematics 14, no. 1 (January 1, 2016): 260–71. http://dx.doi.org/10.1515/math-2016-0024.

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AbstractIn this paper, we present some basic properties concerning the derivation algebra Der (T), the quasiderivation algebra QDer (T) and the generalized derivation algebra GDer (T) of a Lie triple system T, with the relationship Der (T) ⊆ QDer (T) ⊆ GDer (T) ⊆ End (T). Furthermore, we completely determine those Lie triple systems T with condition QDer (T) = End (T). We also show that the quasiderivations of T can be embedded as derivations in a larger Lie triple system.
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Baues, H. J., and F. Muro. "Cohomologically triangulated categories I." Journal of K-Theory 1, no. 1 (January 3, 2008): 3–48. http://dx.doi.org/10.1017/is007011018jkt019.

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AbstractWe introduce cohomologically triangulated categories as triples (A,t,▽) given by an additive category A, an additive equivalence t:AA and a cohomology class ▽ in the translation cohomology H3(A,t). A stable homotopy theory C with A = HoC yields such a triple and the class of distinguished triangles in A is deduced from ▽.
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Baklouti, Amir. "Quadratic Jordan Triple Systems." Journal of Mathematics Research 11, no. 2 (March 4, 2019): 68. http://dx.doi.org/10.5539/jmr.v11n2p68.

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In this work, We show that every Jordan triple system can be viewed as a T∗extension of another one or an ideal of co-dimension one of a Jordan triple system whose represent the T∗extension of another Jordan triple system. Moreover, several result involving the structure of quadratic Jordan triple systems are given.
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Cao, Yan, Jian Zhang, and Yunan Cui. "On split Lie color triple systems." Open Mathematics 17, no. 1 (April 9, 2019): 267–81. http://dx.doi.org/10.1515/math-2019-0023.

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Abstract In order to begin an approach to the structure of arbitrary Lie color triple systems, (with no restrictions neither on the dimension nor on the base field), we introduce the class of split Lie color triple systems as the natural generalization of split Lie triple systems. By developing techniques of connections of roots for this kind of triple systems, we show that any of such Lie color triple systems T with a symmetric root system is of the form T = U + ∑[α]∈Λ1/∼ I[α] with U a subspace of T0 and any I[α] a well described (graded) ideal of T, satisfying {I[α], T, I[β]} = 0 if [α] ≠ [β]. Under certain conditions, in the case of T being of maximal length, the simplicity of the triple system is characterized.
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Nicholson, Ian A., and Hugh S. Paterson. "Modified T graft for triple-vessel disease." Annals of Thoracic Surgery 64, no. 2 (August 1997): 451–53. http://dx.doi.org/10.1016/s0003-4975(97)00538-9.

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Rudenko, A. S. "T-odd triple momentum correlations in decays." Nuclear Physics B - Proceedings Supplements 225-227 (April 2012): 260–62. http://dx.doi.org/10.1016/j.nuclphysbps.2012.02.054.

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Ateljevic, Irena, and Renata Tomljenovic. "Triple T: Tourism, transmodernity and transformative learning." Turisticko poslovanje, no. 17 (2016): 25–31. http://dx.doi.org/10.5937/turpos1617025a.

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Dissertations / Theses on the topic "Triple T"

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Peres, Michaël. "Caractérisation d’une signature sphingolipidique d’immunoéchappement dans le cancer du sein triple négatif." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30337.

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Le cancer du sein est le cancer féminin le plus fréquent et celui qui cause le plus de décès dans le monde. Il existe plusieurs types de cancer du sein qui diffèrent par l’expression des récepteurs aux œstrogènes, à la progestérone et du récepteur HER2. Le cancer du sein dit triple négatif (TNBC) n’exprime aucun de ces récepteurs. Le métabolisme des sphingolipides (SL) est fréquemment altéré dans les cancers du sein et semble participer à la progression tumorale. Tandis que les SL ont été décrits comme modulateurs des réponses immunitaires dans des modèles précliniques de cancer, il n’existe pas à ce jour d’étude chez l’Homme évaluant l’impact des altérations du métabolisme des SL sur le développement tumoral et la réponse immunitaire associée. Dans ce contexte, l’objectif de nos travaux est double. Le premier objectif est de caractériser une signature sphingolipidique dans des biopsies de tumeurs mammaires humaines de divers sous-types histologiques. Une analyse par spectrométrie de masse à haute résolution nous a permis d’identifier dans les TNBC des taux élevés de SL en -C24:0, qui pourraient constituer des biomarqueurs potentiels pour ce type de cancer. Le deuxième objectif est d’établir une signature sphingolipidique associée à la réponse immunitaire dans le cancer du sein. Nous avons analysé les lymphocytes infiltrant la tumeur (TIL) par cytométrie en flux et par immunohistochimie dans nos échantillons tumoraux. Ces analyses nous ont permis de montrer que, dans les TNBC, les taux de C16:0-céramide sont corrélés positivement avec la proportion de TIL CD8+ et négativement avec celle des Treg FoxP3+. Afin d’évaluer l’influence potentielle des SL sur la topologie d’infiltration des lymphocytes (intratumoral versus adjacent), nous avons aussi comparé les taux de SL dans les tumeurs ayant une forte ou une faible proportion de lymphocytes T CD8+ intratumoraux. Nous avons observé notamment des taux élevés de sphingosine-1-phosphate (S1P) dans les tumeurs faiblement infiltrées par les lymphocytes T CD8+ intratumoraux. Nos observations suggèrent que la production de C16:0-céramide soit en faveur d’un recrutement préférentiel des lymphocytes T CD8+ dans les TNBC, tandis que la S1P pourrait être un facteur d’immunoéchappement, impactant négativement sur la topologie des TIL CD8+ dans les tumeurs mammaires. L’ensemble de nos travaux indique que certains SL pourraient constituer des biomarqueurs originaux de TNBC. De plus, la reprogrammation de ce métabolisme pourrait augmenter (i) quantitativement et qualitativement l’infiltration intratumorale des lymphocytes, et (ii) potentiellement l’efficacité des immunothérapies dans le cancer du sein
Breast cancer, the most common malignancy affecting women, is responsible for the majority of woman death by cancer worldwide. There are three different breast cancer types defined by the expression of oestrogen and progesterone and HER2 receptors. The so-called triple negative breast cancer (TNBC), doesn’t express any of these receptors. Sphingolipid (SL) metabolism is frequently altered in breast cancer, alterations are associated with tumour progression. Although SL can act as immune response modulators in preclinical cancer models, there are, to date, no study assessing the impact of SL metabolism alterations on tumor development and associated immune response in Humans. In this setting, our aim was double. Our first objective was to characterize the SL signature in human mammary tumour biopsies from different pathological subtypes. Using high-resolution mass spectrometry assay, we identified elevated levels of C24:0-SL in TNBC, which could be used as potential biomarkers of this cancer subtype. Our second objective was to identify a SL signature associated with immune responses in breast cancer tissues. Tumour-infiltrating lymphocytes (TIL) were analyzed by flow cytometry and immunohistochemistry. Those analyses showed that, in TNBC, levels of C16:0-ceramide are positively correlated with the proportion CD8+ TIL and negatively correlated with that of FoxP3+ Treg TIL. In order to evaluate the potential influence of SL on the topology of infiltrating lymphocytes (intratumoural versus adjacent), we compared the SL levels in tumors depicting high or low proportions of intratumoral CD8+ T cells. We observed higher levels of sphingosine-1-phosphate (S1P) in low infiltrated intratumoral CD8+ T cells. Our observations suggest that C16:0-ceramide production could favor CD8+ T cell recruitment in TNBC, whereas S1P could act as an immune escape factor, negatively impacting on CD8+ TIL topology in mammary tumours. Our whole work indicates that a set of specific SL could constitute original biomarkers in TNBC. Moreover, reprogramming SL metabolism could improve (i) the infiltration of tumours by lymphocytes, both in terms of quality and quantity, and (ii) possibly, the efficacy of immunotherapy in breast cancer
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Farmiloe, Bridget Joy Anne, and n/a. "An exploration of the personal experience of peer leadership." University of Canberra. Professional & Community Education, 1998. http://erl.canberra.edu.au./public/adt-AUC20060710.094543.

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Drug use and misuse among young people in Australia has caused concern throughout the community and has prompted nationwide action to address the problem. One component of intervention strategies with young people is drug education. Drug education in Australia represents an international philosophy of prevention and takes a harm minimisation approach to intervention. One strategy that has had international success in the area of drug education with young people, and that has been used effectively in health education in Australia since the 1970s, is peer education. Peer drug education involves young people conducting drug education sessions with their peers. An example of peer drug education in Australia is the Teenagers Teaching Teenagers' (Triple T) program, conducted in the Australian Capital Territory (ACT). Evaluations and descriptions of peer drug education programs tend to focus more on outcomes pertaining to program recipients and fail to explore in detail the specific experience of peer leaders. Existing research on the experience of peer leadership does not explore in detail the personal experience of leaders, that being the effect of peer leadership training and duties on leaders' personal perceptions of drugs, their behaviour with drugs and their own feelings and skills. This thesis explores the personal experience of a group of peer leaders who participated in the Triple T program in 1994. It considers their perceptions of the program at the time of training and then goes on to explore the impact of this experience on their formulation of ideas about drugs to the present day. The thesis is a qualitative project which utilises in-depth interviewing and focus groups to gather data and then presents a thematic analysis of participant response. The thesis asks two research questions, 1. What do young men and women involved in the Triple T program take from the experience of peer leadership training and duties? 2. In what way does the Triple T' experience appear to contribute to the development of drug related ideas of these young people in the two years following involvement in the program? The findings suggest that the participants gained information, skills and personal development from the training and generally found it to be a positive experience. However, participants distanced themselves personally from a substantial amount of the training content and did not personally reflect on the training content to any great extent at the time of training. Training processes and some aspects of leadership duties more personally affected them, although again there was personal distancing from this part of the program. In exploring the findings there was difficulty determining the influence of the training experience due to participant reluctance to attribute influence to any one source on the formulation of ideas. Instead, participants describe a complex interaction of influences on the formulation of ideas about drugs and a process which involves maintaining control, upholding the notion of informed choice and incorporating ideas about drugs into the formation of an adult identity. Influences on these ideas include the training, actual experiences with drugs and observations of others. The thesis exploration suggests that being involved in peer drug education does impact on peer leaders but this experience was not personalised to any great degree at the time of training. However, in the following two years, participants called on the training information as well as other influences as they formed their ideas about drugs. The thesis raises some issues of how to maximise leaders' personal connection to the peer drug education process, if this is in fact a desired outcome of peer education. It also suggests the need for further research into the experience of peer leaders who seem to have remained the least considered party in the peer education movement.
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Hidri, Samiha. "Formes bilinéaires invariantes sur les algèbres de Leibniz et les systèmes triples de Lie (resp. Jordan)." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0237/document.

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Dans cette thèse, on étudie la structure de quelques types d'algèbres (binaires et ternaires) munies d'une forme bilinéaire symétrique, non dégénérée et associative (ou invariante). La première partie de cette thèse est consacrée à l'étude des algèbres de Leibniz quadratiques. On montre que ces algèbres sont symétriques. De plus, on utilise la T*-extension et la double extension pour montrer plusieurs résultats sur ce type d'algèbres. Ensuite, on a remarqué que l'anti-commutativité du crochet de Lie donne naissance à de nouveaux types d'invariance pour les algèbres de Leibniz : L'invariance à gauche et l'invariance à droite. Alors, on s'est intéresse à l'étude des algèbres de Leibniz (gauche et droite) munies d'une forme bilinéaire symétrique, non dégénérée et invariante à gauche (et invariante à droite). On prouve que ces algèbres sont Lie admissibles. En second lieu, on s'intéresse aux systèmes triples de Lie et de Jordan. On débute la deuxième partie de cette thèse par la description inductive des systèmes triples de Lie quadratiques au moyen de la double extension. En plus, on introduit la T*extension des systèmes triples de Jordan pseudo-Euclidien. Finalement, on donne deux nouvelles caractérisations des systèmes triples de Jordan semi-simples parmi les systèmes triples de Jordan pseudo-Euclidiens
In this thesis, we study the stucture of several types of algebras endowed with Symmetric, non degenerate and invariant bilinear forms. In the first part, we study quadratic Leibniz algebras. First, we prove that these algebras are symmetric. Then, we use the T*-extension and the double extension to prove some properties of this type of Leibniz algebras. Besides, since we observe that the skew-symmetry of the Leibniz bracket gives rise to other types of invariance for a bilinear form on a Leibniz algebra: The left invariance and the right invariance. We focus on the study of left (resp. right) Leibniz algebras with symmetric, non degenerate and left (resp. right) invariant bilinear form. In particular, we prove that these algebras are Lie admissibles. The second part of this work is dedicated to the study of quadratic Lie triple systems and pseudo-euclidien Jordan triple systems. We start by giving an inductive description of quadratic Lie triple systems using double extension. Next, we introduce the T*-extension of Jordan triple systems. Finally, we give new caracterizations of semi-simple Jordan triple systems among pseudo-euclidian Jordan triple systems
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Rothe, Katherina. "Einfluss CD4+CD25+ regulatorischer T-Zellen auf die hämatopoetische Rekonstitution nach syngener und allogener Stammzelltransplantation in einem dreifach transgenen Mausmodell." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-68783.

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Regulatorische CD4+CD25+ T-Zellen (Tregs) stellen eine kleine Zellpopulation dar (1-5% der peripheren Blutzellen), die hauptsächlich für die Regulierung von Immunreaktionen verantwortlich ist. In der vorliegenden Arbeit wurden diese Zellen gemeinsam mit Stammzellen syngen und allogen kotransplantiert, um ihren Effekt auf das Anwachsen der Spenderzellen und die Rekonstitution der Hämatopoese nach Ganzkörperbestrahlung zu untersuchen. Es wurden humanisierte dreifach transgene Empfängermäuse (C57Bl/6-TTG) verwendet (human CD4+, murin CD4-, human HLA-DR+), wodurch sowohl bei syngener als auch bei allogener Transplantation eine Unterscheidung zwischen Spender- und Empfängerzellen möglich ist. Zunächst wurden CD4+CD25+ T-Zellen durch Separation aus Milzzellen bzw. Buffy Coats gewonnen und in vitro mittels Durchflusszytometrie und ELISpot charakterisiert. Anschließend fanden syngene und allogene Transplantationen mit einer Laufzeit von 61 Tagen statt. Überleben und Gewicht wurden täglich ermittelt und außerdem wurden wöchentlich Blutbilder erstellt und durchflusszytometrische Chimärismusanalysen (murines und humanes CD4, CD8, MHC (H2Db, H2Kd)) durchgeführt. Durch die magnetische Separation konnte die FoxP3-Expression der murinen Zellen (Transplantat) von 1,6% in der Ausgangspopulation auf 68,5% in der CD4+CD25+ Population gesteigert werden. In den ELISpot-Assays zeigten diese separierten Zellen, wie für Tregs typisch, keine Produktion von Interleukin-2. Nach syngener Transplantation (Spender: wildtyp C57Bl/6) von 2x106 Knochenmarkzellen und 1x106 CD4+CD25+ T-Zellen überlebten 100% der Tiere, wie zu erwarten war. Dabei setzte bei Tregs-kotransplantierten Tieren die Blutbildung nach bestrahlungsbedingter Leukozytopenie aufgrund bisher nicht bekannter Mechanismen früher wieder ein und der Donor-Zell-Chimärismus war an Tag 19 nach Transplantation signifikant höher als in der Kontrollgruppe. Dies zeigt, dass regulatorische T-Zellen im syngenen Transplantationsmodell einen positiven Effekt auf die Akzeptanz bzw. das Anwachsen des Transplantats haben. Dieses Modell entspricht klinisch einer autologen Transplantation. Nach einer knochenmarkzerstörenden Therapie werden dem Patienten eigene Stammzellen reinfundiert, um die Blutbildung und das Immunsystem wieder in Gang zu bringen. Der Zusatz von regulatorischen T-Zellen zum autologen Stammzelltransplantat könnte das Anwachsen der Zellen beschleunigen und die gefährliche Phase der Immunsuppression, in der es häufig zu Sekundärinfektionen kommt, verkürzen. Die Transplantation der gleichen Zahl von allogenen Spenderzellen (wildtyp Balb/c) führte überraschend zum Tod aller dreifach transgenen Empfängertiere. Der Vergleich zu Experimenten mit wildtyp C57Bl/6-Empfängertieren zeigte, dass dreifach transgene Mäuse sehr viel höhere Zellzahlen im Transplantat zum Überleben benötigen (Daten nicht gezeigt). Das Ausbleiben der Blutbildung nach der Bestrahlung führte zu vermindertem Allgemeinbefinden, gestörter Futter- und Wassseraufnahme und Exsikkose bis zum Tod bzw. aus Tierschutzgründen zur Euthanasie. Durch Erhöhung der Zellzahl im Transplantat auf 1x107 Knochenmark + 5x106 Milzzellen überlebten 25% der Mäuse, bei 3x107 Knochenmark + 5x106 Milzzellen waren es 50%. Anders als im syngenen Modell führte die Kotransplantation 1,5x106 allogener CD4+CD25+ T-Zellen zu 3x107 Knochenmark + 5x106 Milzzellen zum Versterben der Tiere. Dies verdeutlicht, dass regulatorische T-Zellen in diesem allogenen Transplantationsmodell das Anwachsen des Transplantats behindern (Transplantatversagen). Hier gilt es zu klären, ob dieser Effekt spezifisch für die gewählten Mausstämme ist und welche Mechanismen für das Transplantatversagen verantwortlich sind. In einem dreifach transgenen Mausmodell konnte ein positiver Effekt von regulatorischen T-Zellen auf die Rekonstitution der Hämatopoese bei syngener Kotransplantation nachgewiesen werden. Im allogenen Transplantationsmodell hingegen führte die Kotransplantation CD4+CD25+ T-Zellen zum Versterben der Empfänger. Der beschriebene und schon publizierte positive Effekt spenderspezifischer Tregs zur Behandlung von Graft versus Host Disease nach allogener Stammzelltransplantation widerspricht diesen Ergebnissen nicht, da es bei diesen Patienten schon zum Engraftment von hämatopoetischen Stammzellen gekommen ist. Dies hat weitreichende Konsequenzen für die therapeutische Anwendung regulatorischer T-Zellen bei hämatologischen Erkrankungen in der Human- und Veterinärmedizin
Regulatory CD4+CD25+ T cells (Tregs) represent a small cell population (1-5% of peripheral blood cells) mainly responsible for the regulation of the immune system. In the present work, these cells were cotransplanted with syngeneic and allogeneic stem cells in order to analyze the effect of Tregs on the reconstitution of hematopoiesis after total body irradiation. Humanized triple transgenic hosts (C57Bl/6-TTG) (human CD4+, murine CD4-, human HLA-DR+) were applied allowing differentiation of donor and host cells in syngeneic and allogeneic transplantation settings. Murine and human CD4+CD25+ T cells were magnetically separated out of splenocytes or buffy-coats and characterized in vitro by means of flow cytometry and ELISpot. Afterwards syngeneic and allogeneic transplantation experiments were performed for a period of 61 days. Survival and weight were assessed daily and once a week blood parameters and chimerism analyses (murine and human CD4, CD8, MHC (H2Db/ H2Kd)) were carried out. FoxP3 expression increased from 1,6% in the initial murine cell fraction to 68,5% in the separated CD4+CD25+ T cells. ELISpot assays showed the typical lack of interleukin 2 production of Tregs. After syngeneic transplantation (donor: wildtype C57Bl/6) of 2x106 bone marrow cells and 1x106 CD4+CD25+ T cells, 100% of mice survived what was to be expected. Cotransplanted animals showed earlier reconstitution of hematopoiesis after leukocytopenia and significant higher donor-cell-chimerism on day 19 after transplantation. The mechanisms for this positive effect of Tregs in syngeneic transplantation on the engraftment have to be investigated. This model clinically correspond an autologous transplantation where patients are treated with their own stem cells after a myeloablative treatment (chemotherapy or irradiation). The addition of regulatory T cells to the transplant could accelerate the engraftment and shorten the risky period of immunosuppression. Injection of the same numbers of allogeneic cells (donor: wildtype Balb/c) did not preserve hosts from mortality. Compared to experiments with wildtype recipients, results showed that triple transgenic mice need much higher cell numbers in the transplant for survival (data not shown). The failure of hematopoiesis after irradiation led to reduced general condition, disordered ingestion and exsikkosis leading to death respectively to euthanasia for reasons of protection of animals. By scaling up the cell number in the inoculum to 1x107 bone marrow cells + 5x106 splenocytes 25% of mice survived, with 3x107 bone marrow cells + 5x106 splenocytes survival was 50%. In contrast to syngeneic experiments, cotransplantation of 1,5x106 allogeneic CD4+CD25+ T cells and 3x107 bone marrow cells + 5x106 splenocytes did not prevent animals from mortality. In this allogeneic transplantation model Tregs restrain engraftment (graft failure). It has to be clarified if this effect is specific for the utilized mouse strains and which mechanisms are responsible for the graft failure. In the syngeneic triple transgenic mouse model cotransplantation of CD4+CD25+ T cells showed a positive effect on reconstitution of hematopoiesis after irradiation. In the allogeneic setting however cotransplantation of allogeneic regulatory T cells avoided the engraftment of transplanted cells. The described and published effect of donor-specific Tregs for treatment of graft versus host disease after allogeneic transplantation does not contradict the presented results because treated patients already possessed engrafted hematopoietic stem cells. The results have wide consequences for the therapeutic appliance of regulatory T cells in hematological diseases in human and veterinary medicine
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Mitchell, Therese. "The sustainability of donor funded projects in the health sector / T. Mitchell." Thesis, North-West University, 2013. http://hdl.handle.net/10394/10173.

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The need for donor funding has increased significantly over the last decade. Without donor funding millions of people wouldn’t be alive today. Thanks either to research finding a cure, successful treatment, funds donated for food, aid toward building infrastructure, or giving people the opportunity to further their education. Donor funding thus facilitates a better future. A literature review was conducted to give background on the health sector and how these funds were distributed, ethical clearance, different types of reporting, the role project managers pays in a project and the sustainability of projects. Expenses in different countries were evaluated by gathering data from the internet, while two international funded projects are also used to state how funders divide their line items into different categories. The empirical study used a qualitative research approach by collecting and analysing data obtained from the MDG 2010 report and other freely available data on the web. The main findings from this thesis are: *The Millennium Development Goals (MDG’s) influence donor funding as it gives donors a guide towards funding needs. Donors are also influenced by their own preferences or what poses a burden to them individually. *The different types of reporting required for funding received, delay a project and the bureaucratic structures thereof are a hindrance. *Ethical clearance plays a fundamental role in the outcome of a project, as without ethical clearance a project cannot commence. *The objectives of a project play a critical role when applying for funding. This can change the focus of a project. *Expenses differ from country to country and funders need to take this into account when giving funding to recipient countries. *Project Managers and community involvement plays a critical role in ensuring sustainability of projects. THE SUSTAINABILITY OF DONOR FUNDED PROJECTS IN THE HEALTH SECTOR *The MDG’s are not on track and aid are focus on singular goals instead of multiple goals, to ensure an overall improved result. There is a major gap between needed funds and given funds. A single injection of funds will not be the solution to our health problem; different sectors need to collaborate together as we are facing a multi-dimensional problem. Trade and reform must also form part of this aid, ensuring a sustainable progression in the life’s of people. Donor funded projects may have a sustainable future, when taking in account the abovementioned findings. With the world trend in reporting changing rapidly, cost and management accountants as well as financial accountants and project managers have to equip them to adhere to the new way of reporting, namely integrated and sustainability reporting. South Africa is way behind and needs to catch up fast if they want to stay competitive in the “global donor funding market”. The limitations in this study were that not all expenses were evaluated and only 15 countries were looked at. An indebt look was taken into Africa with the empirical review, while Asia is also combating poor health issues. Some African countries like Sierra Leone and Zimbabwe did not have sufficient data to compare with other countries. From the research conducted, the following topics were identified that require further research: *Why are most projects in Third World countries not sustainable? *What plans are put into action to ensure that the MDG goals are reached? *Investigate what works for First World countries health systems and consider how that can be applied to Third World countries to ensure that they also get the best health care available. *Do donors take into account the different costs of countries when allocating funding to that specific country? *Establishing models to evaluate the sustainability of pilot projects and normal projects. *Establishing a model on how to distribute donor funds across different needs and not only one specific need.
MCom (Management Accountancy), North-West University, Vaal Triangle Campus, 2013
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GRA?A, Luziray Braga. "A percep??o da comunidade escolar sobre o Instituto Federal do Amazonas campus Tabatinga: realidades e perspectivas." Universidade Federal Rural do Rio de Janeiro, 2016. https://tede.ufrrj.br/jspui/handle/jspui/2461.

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This dissertation is the result of a survey conducted in the city of Tabatinga, interior of the State of Amazonas, located in the triple border Brazil, Colombia and Peru. If addressed, in principle, consistent information to the border region, highlighting the educational, political, economic and social relations between the countries. In addition, the study highlighted the implementation of the Federal Institutes, created by Law 11.892/08, and the operation since its installation in the city of Tabatinga. Its general objective is to understand the perception of the school community about the Instituto Federal de Educa??o, Ci?ncia e Tecnologia do Amazonas (IFAM) - campus Tabatinga, weaving an analysis guided the views of internal and external students at the Institute. At first, the focus of the work focused on the presentation of the IFAM campus Tabatinga to tabatinguense school community, considering the offer of vocational technical education to the population. In the second phase, the research highlighted the perception of the school community about the training at the Federal Institute, established in the municipality. The proposal was developed through an exploratory research, with qualitative and quantitative approaches, and using the literature research, document and case study. As data collection instruments were used participant observation and questionnaires. So with the analysis of the study, we believe that the reality experienced by the school community of Tabatinga, and the prospects of these students make up aspects that enable discussion and planning strategies capable of enhancing positive actions for the educational development process, also remedying the obstacles that hinder local growth, guiding the defining issues of the direction of the institution and the region.
A presente disserta??o ? resultado de uma pesquisa realizada no ?mbito do munic?pio de Tabatinga, interior do estado do Amazonas, localizado na tr?plice fronteira Brasil, Col?mbia e Peru. Abordou-se, a princ?pio, informa??es relativas ? regi?o fronteiri?a, destacando as rela??es educacionais, pol?ticas, econ?micas e sociais entre os pa?ses. Al?m disso, o estudo ressaltou a implanta??o dos Institutos Federais, criados atrav?s da Lei 11.892/08, e a atua??o do IFAM desde sua instala??o na cidade de Tabatinga. Teve como objetivo geral a compreens?o da percep??o da comunidade escolar sobre o Instituto Federal de Educa??o, Ci?ncia e Tecnologia do Amazonas (IFAM) campus Tabatinga, tecendo uma an?lise pautada nas vis?es de alunos internos e externos ao Instituto. No primeiro momento, o foco do trabalho concentrou-se na apresenta??o do IFAM campus Tabatinga ? comunidade escolar tabatinguense, considerando a oferta da educa??o t?cnica profissional ? popula??o. No segundo momento, a pesquisa destacou a percep??o da comunidade escolar quanto ? forma??o no Instituto Federal, implantado no munic?pio. A proposta foi desenvolvida atrav?s de uma pesquisa explorat?ria com abordagens qualitativa e quantitativa, utilizando-se a investiga??o bibliogr?fica, documental e o estudo de caso. Como instrumentos de coleta de dados foram empregados a observa??o participante e o uso de question?rios. Assim, atrav?s da an?lise do estudo, considerou-se que a realidade vivenciada pela comunidade escolar de Tabatinga, bem como as perspectivas desses estudantes, comp?e aspectos que possibilitam a discuss?o e o planejamento de estrat?gias capazes de intensificar a??es positivas em prol do processo de evolu??o educacional, sanando tamb?m os entraves que dificultam o crescimento local, norteando as quest?es definidoras dos rumos da institui??o e da regi?o.
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Pfeifer, Rita [Verfasser], and Stefan [Akademischer Betreuer] Stevanovic. "Evaluation of SSEA-4 as a CAR T cell therapeutic target for the treatment of chemoresistant triple negative breast cancers / Rita Pfeifer ; Betreuer: Stefan Stevanovic." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1173700102/34.

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Voloshina, Elena, Denis Usvyat, Martin Schütz, Yuriy Dedkov, and Beate Paulus. "On the physisorption of water on graphene: a CCSD(T) study." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-138776.

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The electronic structure of the zero-gap two-dimensional graphene has a charge neutrality point exactly at the Fermi level that limits the practical application of this material. There are several ways to modify the Fermi-level-region of graphene, e.g. adsorption of graphene on different substrates or different molecules on its surface. In all cases the so-called dispersion or van der Waals interactions can play a crucial role in the mechanism, which describes the modification of electronic structure of graphene. The adsorption of water on graphene is not very accurately reproduced in the standard density functional theory (DFT) calculations and highly-accurate quantum-chemical treatments are required. A possibility to apply wavefunction-based methods to extended systems is the use of local correlation schemes. The adsorption energies obtained in the present work by means of CCSD(T) are much higher in magnitude than the values calculated with standard DFT functional although they agree that physisorption is observed. The obtained results are compared with the values available in the literature for binding of water on the graphene-like substrates
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
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Voloshina, Elena, Denis Usvyat, Martin Schütz, Yuriy Dedkov, and Beate Paulus. "On the physisorption of water on graphene: a CCSD(T) study." Royal Society of Chemistry, 2011. https://tud.qucosa.de/id/qucosa%3A27779.

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The electronic structure of the zero-gap two-dimensional graphene has a charge neutrality point exactly at the Fermi level that limits the practical application of this material. There are several ways to modify the Fermi-level-region of graphene, e.g. adsorption of graphene on different substrates or different molecules on its surface. In all cases the so-called dispersion or van der Waals interactions can play a crucial role in the mechanism, which describes the modification of electronic structure of graphene. The adsorption of water on graphene is not very accurately reproduced in the standard density functional theory (DFT) calculations and highly-accurate quantum-chemical treatments are required. A possibility to apply wavefunction-based methods to extended systems is the use of local correlation schemes. The adsorption energies obtained in the present work by means of CCSD(T) are much higher in magnitude than the values calculated with standard DFT functional although they agree that physisorption is observed. The obtained results are compared with the values available in the literature for binding of water on the graphene-like substrates.
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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Broad, Barbara Patricia, and n/a. "An analysis of peer drug education : a case study." University of Canberra. Education, 1992. http://erl.canberra.edu.au./public/adt-AUC20060613.132241.

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Drug use and misuse by young people is a problem and concern in the Australian and Australian Capital Territory (ACT) communities. There are concerns regarding illicit and licit drugs but licit drug use has been identified as the major area of concern. Young people in the ACT reflect the drug use/misuse patterns and trends of other states. Commonly used drugs by young people are alcohol, tobacco, cannabis and analgesics. Strategies to address the problem of drug use/misuse by young people include intervention and community drug education programs. Peer drug education (as an example of community drug education), trains young people as peer educators to implement drug education programs with younger age groups. A case study analysis based on qualitative, naturalistic and new paradigm research is the research method used in this thesis. An eclectic model of drug education including key components from a variety of drug education models provides a comprehensive overview of peer drug education. The literature review showed the complexity of influences on drug use/misuse. These influences relate to individual, peer, parental and family, community and societal factors. Peer drug education is generally recognised as an effective drug education strategy. Peer drug education programs (Triple T: Teenagers Teaching Teenagers) were conducted in the ACT from 1988-1990. Reports documenting these programs (including evaluation data) and a literative review are the main data analysed for the case study. The case study analysis of five ACT peer drug education programs and one interstate program showed the key planning issues for effective peer drug education were: collaborative decision making as a central concept; detailed planning and liaison with target groups; established structures within schools and communities to support the trained peer educators; team work and small group work as intrinsic and extrinsic factors within the program; clarification of responsibilities and roles of all personnel involved in the program; and facilitators/leaders with attributes and qualities that encourage peer drug educators as social change agents. Analysis of data from the case study reports showed young people can be effective peer drug educators. Residential programs are preferred over non-residential programs. Peer drug education programs are effective in both school and community agencies. The literature review and analysis of reports also indicated that peer drug education needs to focus on establishing positive norms in groups of young people. Collaborative decision making and positive role modelling assist in the establishment of these norms. Peer drug education links to the wider changes occurring in education and health settings. Peer drug education is about collaborative decision making, social justice, development of key competencies and social change. This thesis confirmed the complexity and dynamic nature of peer drug education and there were many questions raised for further research from the literature review and analysis of program reports.
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Books on the topic "Triple T"

1

Hemingway, Bruce S. On the AlSiO triple point and the natural occurrence of two AlSiO polymorphs under the same P-T conditions. Reston, VA: U.S. Geological Survey, 1992.

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al-T ̣abīʻah al-qānūnīyah li-Ghurfat al-Shūrá. Marrākush: Tawzīʻ Maktabat al-Manārah Kutub, 2002.

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Simpson, Anne Key. Hard trials: The life andmusic of Harry T. Burleigh. Metuchen: Scarecrow, 1990.

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A-t-on jugé Marie Besnard?: Le dossier de l'affaire. Bordeaux-Le Bouscat: L'Esprit du Temps, 1995.

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Simpson, Anne Key. Hard trials: The life and music of Harry T. Burleigh. Metuchen, N.J: Scarecrow Press, 1990.

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Akayesu, Jean-Paul. The prosecutor versus Jean-Paul Akayesu: Case no. ICTR 96-4-T : judgement. Arusha, Tanzania]: United Nations, International Criminal Tribunal for Rwanda, 1998.

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Diabaté, Modibo. Jésus a-t-il dit la vérité à ses juges? Paris: Éditions Edilivre AParis, 2011.

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Kayishema, Clément. The prosecutor versus Clément Kayishema and Obed Ruzindana: Case no. ICTR-9501-T : judgement. [Arusha, Tanzania]: United Nations, International Criminal Tribunal for Rwanda, 1999.

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Kayishema, Clément. The prosecutor versus Clément Kayishema and Obed Ruzindana: Case no. ICTR-9501-T : judgement. [Arusha, Tanzania]: United Nations, International Criminal Tribunal for Rwanda, 1999.

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Evans, Don. The trials and tribulations of Staggerlee Booker T. Brown: A play in two acts. New York, N.Y. (440 Park Ave. S., New York 10016): Dramatists Play Service, 1985.

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Book chapters on the topic "Triple T"

1

Rahman, Md Saifur, and Hassan Reza. "Big Data Analytics in Social Media: A Triple T (Types, Techniques, and Taxonomy) Study." In Advances in Intelligent Systems and Computing, 479–87. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-70416-2_62.

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Hsiao, Feng-Hsiag, and Po-Han Lin. "Applying Triple Data Encryption Algorithm to a Chaotic Systems: T-S Fuzzy Model-Based Approach." In Information Science and Applications 2018, 53–66. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1056-0_6.

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Faifman, M. P., and L. I. Ponomarev. "Resonant formation of dtμ mesic molecules in the triple H 2 + D 2 + T 2 mixture." In The Future of Muon Physics, 210–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77960-2_33.

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Bohm, Lisa. "T-SQL Triage." In Refactoring Legacy T-SQL for Improved Performance, 3–19. Berkeley, CA: Apress, 2020. http://dx.doi.org/10.1007/978-1-4842-5581-0_1.

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Schneiders, Famke L., Rik J. Scheper, Hetty J. Bontkes, B. Mary E. von Blomberg, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, and Hans J. van der Vliet. "Clinical Trials with α-Galactosylceramide (KRN7000) in Advanced Cancer." In Natural Killer T cells, 169–83. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0613-6_10.

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Motohashi, Shinichiro, Yoshitaka Okamoto, and Toshinori Nakayama. "Clinical Trials of Invariant Natural Killer T Cell-Based Immunotherapy for Cancer." In Natural Killer T cells, 185–98. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0613-6_11.

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Guelachvili, G., and N. Picqué. "Table 50. H2 16O (H16OH): Spectroscopic constants derived from the CCSDT − 1 Potential Energy Surface (PES) (CCSD(T): Coupled Cluster with Single and Double and partial Triple excitations)." In Non-linear Triatomic Molecules, 149–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-47383-1_52.

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Suppan, Arnold. "Masaryk and the Trials for High Treason against South Slavs in 1909." In T. G. Masaryk (1850–1937), 210–24. London: Palgrave Macmillan UK, 1990. http://dx.doi.org/10.1007/978-1-349-20596-7_10.

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Guelachvili, G., and N. Picqué. "Table 49. H2 16O (H16OH): Normal coordinate force constants derived from the CCSDT − 1 Potential Energy Surface (PES) (CCSD(T): Coupled Cluster with Single and Double and partial Triple excitations)." In Non-linear Triatomic Molecules, 147–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-47383-1_51.

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Rischin, Danny. "Biomarkers for Immune Modulatory Treatment in Head and Neck Squamous Cell Carcinoma (HNSCC)." In Critical Issues in Head and Neck Oncology, 83–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_6.

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AbstractImmune checkpoint inhibitors have changed the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, only a minority of patients respond, hence the search for predictive biomarkers. Potential predictive biomarkers for immune checkpoint inhibitors discussed in this chapter include (1) Immune checkpoint ligand expression e.g., PD-L1, (2) biomarkers of a T-cell inflamed tumour microenvironment (TME) such as gene expression profiles of activated T cells, (3) biomarkers of tumour neoepitope burden such as tumour mutation burden (TMB) and (4) multidimensional quantitative techniques. At present only PD-L1 expression has been shown to have clinical utility in head and neck cancer. It enriches for populations more likely to respond, but the false positive predictive value remains high. In the pivotal Keynote−048 trial that established a role for pembrolizumab (anti-PD1) monotherapy and pembrolizumab + chemotherapy as treatment options in first-line R/M HNSCC, primary endpoints included overall survival in defined subgroups based on PD-L1 expression. In this trial the combined positive score (CPS) was used which takes into account PD-L1 expression in tumour and immune cells. Based on this trial regulatory approvals for first-line pembrolizumab in R/M HNSCC require assessment of PD-L1 expression using the CPS. Finally we discuss emerging evidence that locoregionally advanced HPV-associated oropharyngeal cancers that have high expression of CD103 positive CD8 T cells have an excellent prognosis and features that suggest increased probability of responding to anti-PD1/PD-L1, raising the possibility of incorporating these immune therapies as part of a de-escalation trial strategy.
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Conference papers on the topic "Triple T"

1

Hartmann, Bjoern. "Session details: Triple t: touch, tables, tablets." In CHI '12: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2012. http://dx.doi.org/10.1145/3250508.

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Bensalem, Wafia. "T-odd triple product asymmetries in beauty decays." In High energy physics at the millennium: MRST (Montreal-Rochester-Syracuse-Ontario)’99 "The sundarfest". American Institute of Physics, 1999. http://dx.doi.org/10.1063/1.1301300.

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Naumenko, V., V. Solodovnik, A. Totsky, A. Zelensky, and J. Astola. "Bispectrum-based demodulation technique using triple-channel heterodyning of triplet-signal." In 2015 Second International Scientific-Practical Conference Problems of Infocommunications Science and Technology (PIC S&T). IEEE, 2015. http://dx.doi.org/10.1109/infocommst.2015.7357319.

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Caillaud, B., B. Bellini, and J. L. de Bougrenet de la Tocnaye. "High speed large viewing angle shutters for triple-flash active glasses." In IS&T/SPIE Electronic Imaging, edited by Andrew J. Woods, Nicolas S. Holliman, and John O. Merritt. SPIE, 2009. http://dx.doi.org/10.1117/12.807094.

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Tumari, N. F., M. F. Jamlos, H. Lago, and S. K. A. Rahim. "T-shape slotted array antenna through via for triple band applications." In 2015 IEEE International RF and Microwave Conference (RFM). IEEE, 2015. http://dx.doi.org/10.1109/rfm.2015.7587722.

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Xu, Zhaodi, Xiaoyi Li, and Wanxi Chou. "New method of constructing triple system with order s×t." In 2012 24th Chinese Control and Decision Conference (CCDC). IEEE, 2012. http://dx.doi.org/10.1109/ccdc.2012.6244603.

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YASHIRO, Tsukasa. "CELL-COMPLEXES FOR t-MINIMAL SURFACE DIAGRAMS WITH 4 TRIPLE POINTS." In Intelligence of Low Dimensional Topology 2006 - The International Conference. WORLD SCIENTIFIC, 2007. http://dx.doi.org/10.1142/9789812770967_0047.

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Luo, Minxia, and Xiaoling Zhou. "Reverse Triple I Algorithms Based on Schweizer-Sklar Interval-Valued t-Norms." In 2015 10th International Conference on Intelligent Systems and Knowledge Engineering (ISKE). IEEE, 2015. http://dx.doi.org/10.1109/iske.2015.10.

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Li, Xiao-Yi, Zhao-Di Xu, and Wan-Xi Chou. "Construction and enumeration of Steiner triple systems with order s×t." In 2011 23rd Chinese Control and Decision Conference (CCDC). IEEE, 2011. http://dx.doi.org/10.1109/ccdc.2011.5968971.

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Luo, Minxia, and Ni Sang. "Triple I method based on residuated implications of left-continuous pseudo-t-norms." In 2012 9th International Conference on Fuzzy Systems and Knowledge Discovery (FSKD). IEEE, 2012. http://dx.doi.org/10.1109/fskd.2012.6233740.

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Reports on the topic "Triple T"

1

Colgan, James P., and Gregory Armstrong. T-shape break-up patterns in the triple photoionization of Li. Office of Scientific and Technical Information (OSTI), April 2013. http://dx.doi.org/10.2172/1073730.

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Abachi, S. Measurement of inclusive triple differential dijet cross section, d{sup 3}{sigma}/dE{sub T}d{eta}{sub 1}d{eta}{sub 2} in p{bar p} collisions at {radical}s = 1.8 TeV. Office of Scientific and Technical Information (OSTI), July 1995. http://dx.doi.org/10.2172/96930.

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White, Richard M., John P. McConnell, and Daniel S. Newton. Analysis of Trimble Mini-T GPS Receiver. Fort Belvoir, VA: Defense Technical Information Center, March 2009. http://dx.doi.org/10.21236/ada499938.

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Junghans, Richard P. Trials of Anti-PSMA Designer T Cells in Advanced Prostate Cancer (Phase 1). Revision. Fort Belvoir, VA: Defense Technical Information Center, July 2007. http://dx.doi.org/10.21236/ada477450.

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Junghans, Richar P. Trial of Anti-PSMA Designer T Cells in Advanced Prostate Cancer. Phase 1. Fort Belvoir, VA: Defense Technical Information Center, July 2006. http://dx.doi.org/10.21236/ada484575.

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Drommond, Ray. Normative data for the Tennessee test of rhythm and intonation patterns (T-TRIP). Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.3288.

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Gulley, James, William Dahut, Philip M. Arlen, Kwong Tsang, and Jeffrey Schlom. Analysis of PSA-Specific T-Cell Responses of Prostate Cancer Patients Given a PSA-Based Vaccine on a Clinical Trial. Fort Belvoir, VA: Defense Technical Information Center, April 2003. http://dx.doi.org/10.21236/ada428064.

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Lee, Chung, Timothy Kuzel, Richard Meagher, Ximing Yang, Norm Smith, and Qiang Zhang. Preparation for a Clinical Trial Using Adoptive Transfer of Tumor-Reactive TGF_Beta-Insensitive CD8+ T Cells for Treatment of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2006. http://dx.doi.org/10.21236/ada462885.

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Lee, Chung. Preparation for a Clinical Trial Using Adoptive Transfer of Tumor-Reactive TGF_Beta-Insensitive CD8+ T Cells for Treatment of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2006. http://dx.doi.org/10.21236/ada463479.

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Frisancho, Verónica, and Martín Valdivia. Savings Groups Reduce Vulnerability, but Have Mixed Effects on Financial Inclusion. Inter-American Development Bank, December 2020. http://dx.doi.org/10.18235/0002910.

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This paper evaluates the impact of the introduction of savings groups on poverty, vulnerability, and financial inclusion outcomes in rural Peru. Using a cluster randomized control trial and relying on both survey and administrative records, we investigate the impact of savings groups after more than two years of exposure. We find t hat savings groups channel expensive investments such as housing improvements and reduce households' vulnerability to idiosyncratic shocks, particularly among households in poorer districts. The treatment also induces changes in households labor allocation choices: access to savings groups increases female labor market participation and, in poorer areas, it fosters greater specialization in agricultural activities. Access to savings groups also leads to a four-percentage point increase in access to credit among women, mainly driven by access to the groups loans. However, the introduction of savings groups has no impact on the likelihood of using formal financial services.On the contrary, it discourages access to loans from formal financial institutions and microfinance lenders among the unbanked.
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