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Journal articles on the topic 'Trigonella foenum graecum Linn'

Author: Grafiati

Published: 18 May 2024

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1

Susilawati, Putu, Bagus Komang Satriyasa, and I. Gusti Ayu Widianti. "Pemberian Ekstrak Etanol Biji Klabet (Trigonella foenum-graecum L.) Menurunkan Kualitas Spermatozoa Mencit (Mus musculus) Dewasa Muda." Metamorfosa: Journal of Biological Sciences 9, no. 2 (October 19, 2022): 318. http://dx.doi.org/10.24843/metamorfosa.2022.v09.i02.p11.

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Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol Biji Klabet (Trigonella foenum-graecum Linn.) dapat menurunkan kualitas spermatozoa mencit (Mus musculus) dewasa muda sebagai bahan kontrasepsi pria alami. Penelitian ini merupakan penelitian eksperimental dengan menggunakan rancangan penelitian post-test only control group design. Sampel penelitian ini terdiri dari 36 ekor mencit (Mus musculus) jantan galur Swiss Webster usia 2-3 bulan dengan berat badan 20-30 gram yang dibagi menjadi dua kelompok secara acak. Kelompok kontrol (P0) diberikan CMC Na 0,3% sebanyak 0,5 ml dan kelompok perlakuan (P1) diberikan ekstrak etanol Biji Klabet (Trigonella foenum-graecum Linn.) 0,4 mg/gram BB sebanyak 0,5 ml selama 36 hari per oral. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak etanol Biji Klabet (Trigonella foenum-graecum Linn.) dapat menurunkan kualitas (konsentrasi, motilitas, viabilitas, dan morfologi) spermatozoa (P?0,05), sehingga Biji Klabet (Trigonella foenum-graecum Linn.) memiliki potensi sebagai bahan alami kontrasepsi pria.

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2

B Kadam, Vasant. "Phytochemical Profile of Trigonella foenum graecum Linn." International Journal of Pharmaceutics & Pharmacology 2, no. 2 (June 30, 2018): 1–4. http://dx.doi.org/10.31531/2581-3080.1000130.

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3

Kapoor*, Madhu Kanta, and Sasikumar S. "Comparative foliar studies in saline sand and fresh water soil - grown Trigonella foenum - graecum Linn. plants." International Journal of Bioassays 6, no. 03 (February 28, 2017): 5304. http://dx.doi.org/10.21746/ijbio.2017.03.004.

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Vegetable markets in Mumbai sell “methi” at two stages of growth, the full grown vegetative to flowering stage and another at two cotyledonary-leaves stage. The latter are commonly grown in the sandy beaches of Mumbai whereas the former are the regular soil-grown ones. The beach grown Trigonella foenum-graecum L. plants are watered with saline beach- well waters whereas the soil-grown ones are watered with regular fresh water. The research work focused on studying the impact of this difference in growing conditions on many growth parameters, viz., morphology, anatomy and biochemical analyses of the sand and soil-grown plants in addition to sand, soil and water analyses. Current paper deals with the impact of these different growing conditions on some foliar parameters viz., anatomy, stomatal index, palisade ratio and venation patterns, in the two types of Trigonella foenum-graecum L. plants.

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4

Agustini, Kurnia, Wahono Sumaryono, and R. Micho Widyanto. "Activity of Trigonella foenum-graecum on Some Cell Lines." Indonesian Journal of Cancer Chemoprevention 2, no. 2 (June 28, 2011): 234. http://dx.doi.org/10.14499/indonesianjcanchemoprev2iss2pp234-241.

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Trigonella foenum-graecum (TFG) is one of medicinal plants contains some steroidal sapogenin such as diosgenin, yamogenin, gitogenin, tigogenin and trigoneoside, also alkaloid trigonellin, which is have many activity as antidiabetic, estrogenic and also as anti cancer. This experiment was done to explore the activity of some extract of TFG on some cell lines such as MCF7 (Human Breast Cancer Cell-line), T47D (Human Breast Cancer Cell-line), PC3 (Human Prostate Cell-line) and SKOV (Human Ovarian Carcinoma Cell-line). This assay was done using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium) methods. Results showed that ethyl acetate fraction gives the lowest IC50 than another extracts. IC50 for PC3 is 66.24 ppm, IC50 for MCF7 is 41.81 ppm, IC50 for T47D is 58.63 ppm. These datas can be used for further research to isolate the active compound from TFG.Keywords : Trigonella foenum-graecum, MCF-7, T47D, SKOV, PC3

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5

Chourasiya, Anand, Rakesh Kumar Sahu, and Mohd Azaz Khan. "Anti-Anemic and Haemopoietic Evaluation of Trigonella foenum-graecum (Fenugreek) in Rodent Model." Journal of Drug Delivery and Therapeutics 9, no. 4-s (August 15, 2019): 332–37. http://dx.doi.org/10.22270/jddt.v9i4-s.3335.

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The health benefits and medicinal properties of herbal food products are known since antiquity. Fenugreek, Trigonella foenum-graecum Linn (T. foenum-graecum, Fabaceae), a seed spice used to enhance flavor, color and texture of food is employed for medicinal purposes in many traditional systems. Ethno botanical survey of T. foenum-graecum revealed the seeds of the plant to be useful in anemia. The objective of this study was to study the ant-anemic effect of hydroalcoholic extract of seeds of T. foenum-graecum against phenylhydrazine induced anemic rat model. The hydroalcoholic extracts of seeds were prepared by soxhlation. Phytochemical analysis of the extracts was performed using standard testing procedures. Hemolytic anemia was induced in male Wistar rats by intraperitoneal administration of phenylhydrazine HCl (PHZ) at doses of 40 mg/kg of body weight during two successive days then one day after the animals were treated orally by the hydroalcoholic extracts with the amounts of 200 mg/kg and 400 mg/kg of body weight and Dexorange (reference drug) up to 13 days. The rats were analyzed for hematological parameters such as hemoglobin (Hb), red blood cell count (RBC) and white blood cell count (WBC) on day 2 and 13. Phytochemical screening of the extracts indicated the presence of carbohydrates, saponins, sterols, polyphenols, tannins and flavonoids. Anemia was induced successfully in Groups II, III, IV and V which was indicated by a mean reduction of 51.6% in RBC count; 52.85% in Hb content and 54.9% in WBC. Analysis of hematological parameters on day 13 showed that extract significantly (p<0.05) improved Hb, RBC and WBC count at a dose of 400 mg/kg body weight. This study, not only substantiates the folklore use of the seed of T. foenum-graecum, but also suggests its inclusion in the treatment of anemia as it exhibited significant anti-anemic activity Keywords: Trigonella foenum-graecum, Anemia, Phytochemical analysis, Phenyl hydrazine, Dexorange

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6

Nahar, Nilufar, and AKM Ahsan Habib. "Soluble dietary fibers from Trigonella foenum graecum Linn. seed and their structures." Journal of Bangladesh Academy of Sciences 38, no. 1 (August 27, 2014): 19–26. http://dx.doi.org/10.3329/jbas.v38i1.20201.

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Soluble dietary fibers of Trigonella foenum graecum Linn. seed were isolated and fractionatedinto neutral and acidic parts. Structures of both the fractions were determined by sugar analysis andhigh resolution 2D NMR spectroscopic studies including total correlation (TOCSY) spectroscopy.Main chain of the neutral SDF fraction was found to be a galactomannan composed of mannoseand galactose (~1 : 1.5 ratio) having 1,3-? linkages between each other. Terminal mannose residuewas linked to galactose residue of the main chain at its 4 position by ?-linkage. The acidic SDF wasa rhamnogalacturonan, in the main chain, galacturonic acids and rhamnose had 1,4-?- and 1,2-?-linkeages, respectively. Terminal ?-galactose and ?-glucuronic acid were linked to ?-galacturonicacid of the main chain at its 3-position DOI: http://dx.doi.org/10.3329/jbas.v38i1.20201 Journal of Bangladesh Academy of Sciences, Vol. 38, No. 1, 19-26, 2014

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7

Pundarikakshudu, Kilambi, DeepakH Shah, AashishH Panchal, and GordhanbhaiC Bhavsar. "Anti-inflammatory activity of fenugreek (Trigonella foenum-graecum Linn) seed petroleum ether extract." Indian Journal of Pharmacology 48, no. 4 (2016): 441. http://dx.doi.org/10.4103/0253-7613.186195.

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8

Assad, Tahira, Rafeeq Alam Khan, and Muhammad Ali Rajput. "Effect of Trigonella foenum-graecum Linn. seeds methanol extract on learning and memory." Metabolic Brain Disease 33, no. 4 (April 21, 2018): 1275–80. http://dx.doi.org/10.1007/s11011-018-0235-1.

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9

Agustini, Kurnia, Firdayani Firdayani, and Churiyah Churiyah. "Cytotoxic Activity on MCF-7 Cells and in Silico Study of Sapogenin Steroids From Trigonella foenum-graecum L." Indonesian Journal of Cancer Chemoprevention 6, no. 1 (January 30, 2017): 1. http://dx.doi.org/10.14499/indonesianjcanchemoprev6iss1pp1-6.

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Trigonella foenum-graecum (TFG) is one of medicinal plants containing several steroidal sapogenins, such as diosgenin, yamogenin, gitogenin, tigogenin and trigoneoside, and also alkaloid trigonellin and some flavonoids such as vitexin, isovitexin, orientin, isoorientin, which has many activities, such as antidiabetic, estrogenic, and also anticancer. As phytoestrogen, TFG was predicted to have potency as Selective Estrogen Receptor Modulators (SERMs) which is used for hormonal-dependent breast cancer treatment. This experiment was carried out to investigate interaction of some sapogenin steroids and flavonoids in TFG to estrogen receptor alpha (ERα) and its activity to breast cancer cell line as confirmation. In silico prediction was carried out to investigate their estrogenic activity by analyzing their binding affinity to ERα using AutoDock Vina program. In vitro activity confirmation of TFG extract and its fractions were carried out using MTT assay on Erα-positive human breast cancer cell line, MCF-7. Results showed that free binding energies of diosgenin and yamogenin were -6.4 kcal/mol, estradiol was -6.0 kcal/mol, and tamoxifen was -5.1 kcal/mol. While cytotoxicity assay showed that ethyl acetate fraction gave the lowest IC50 of 41.81 ppm, with total steroid content of 20.03 ppm. From these results, we can conclude that diosgenin and yamogenin have greater binding affinity to ERα comparing to estradiol and tamoxifen. In vitro assay confirmation showed that ethyl acetate fraction has cytotoxic effect on MCF-7 cells.Keywords: Trigonella foenum-graecum, sapogenin steroids, MCF-7, estrogen receptor alpha, binding affinity

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10

Zahra, Kaenat, Abdullah ., and Razia Shaheen. "Hulba (Trigonella foenum graecum Linn.): the blessed medicinal herb of Unani System of Medicine." American Journal of PharmTech Research 9, no. 6 (December 8, 2019): 267–77. http://dx.doi.org/10.46624/ajptr.2019.v9.i6.023.

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11

Kasaye, Tamiru. "Utilization of Fenugreek (Trigonella foenum-graecum Linn) to Develop Value Added Biscuits and Breads." European Journal of Nutrition & Food Safety 5, no. 5 (January 10, 2015): 602–3. http://dx.doi.org/10.9734/ejnfs/2015/20986.

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12

Daman, Janhavi Jatin, Radiya Pacha-Gupta, and Nandita Mangalore. "Maltase Inhibitory Activity of Aqueous Extracts of Zingiber officinale Rosc. and Trigonella foenum-graecum Linn." Pharmacognosy Journal 10, no. 2 (March 15, 2018): 226–29. http://dx.doi.org/10.5530/pj.2018.2.39.

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13

John, Biby Sara, Sophia D, Ramamurthy V, and Mathew Joe Prasad. "Chemopreventive Activities of Trigonella foenum graecum Against Hepatocellular Carcinoma Cell Line." International Journal of Zoological Investigations 9, no. 2 (2023): 1188–97. http://dx.doi.org/10.33745/ijzi.2023.v09i02.132.

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14

Hanafi, Noorul Izzati, Noor Hafizoh Saidan, Maizan Mohamed, KNS Sirajudeen, Siew Hua Gan, Khomaizon A. K. Pahirulzaman, and Rao Pasupuleti Visweswara. "REVIEW: ISCHEMIC HEART DISEASE AND THE POTENTIAL ROLE OF FENUGREEK (TRIGONELLA FOENUM GRAECUM LINN.) IN CARDIOPROTECTION." Jurnal Teknologi 84, no. 2 (February 23, 2022): 183–97. http://dx.doi.org/10.11113/jurnalteknologi.v84.17542.

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Ischemic heart disease, often known as coronary heart disease (CHD), is a term for heart disorders caused by narrowing heart arteries (coronary arteries) that provide blood to the heart's muscles. The body is prone to heart attacks when there is less oxygen supply (hypoxia) to the heart resulting a major cell death in the heart tissues. Cardiovascular disease (CVD) is the leading cause of death worldwide. Over the last few decades, the potential therapeutic effects of herbs and other types of complementary medicines for managing risk factors for CVD have gotten a lot of attention. Fenugreek (Trigonella foenum graecum Linn.) is a very important spice in most Asian dishes. In Malaysia, fenugreek, locally known as ‘halba’, is used in the preparation of popular dishes; ‘nasi dagang’ for breakfast, and ‘putu halba’ as snacks for hi-tea and sometimes applied in drinks. Although, to date, the effect of fenugreek against diabetes and heart diseases is well investigated, most studies do not focus on its the effects at molecular levels. This review gives an insight on the ischemic heart disease and the nutritional values of fenugreek as functional food in protecting the heart.

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15

Osman Magdoleen G, Daffalla H M, Ahmad Magda M M, Ali Kauther Sir el-khatim, Saleh Salma A, and Hamza Abdelhalim A. "Total phenolic content, antioxidant and antimicrobial activities of seeds and callus of Trigonella foenum-graecum Linn." GSC Biological and Pharmaceutical Sciences 10, no. 3 (March 30, 2020): 001–9. http://dx.doi.org/10.30574/gscbps.2020.10.3.0033.

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16

Pawar, Vinod S., and Shivakumar Hugar. "Adaptogenic activity of Trigonella foenum graecum (Linn) seeds in rodents exposed to anoxia and immobilization stress." Asian Pacific Journal of Tropical Biomedicine 2, no. 1 (January 2012): S208—S211. http://dx.doi.org/10.1016/s2221-1691(12)60161-0.

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17

Puri, D., K. M. Prabhu, and P. S. Murthy. "Antidiabetic Effect of GII Compound Purified from Fenugreek (Trigonella foenum graecum Linn) Seeds in Diabetic Rabbits." Indian Journal of Clinical Biochemistry 27, no. 1 (September 20, 2011): 21–27. http://dx.doi.org/10.1007/s12291-011-0151-1.

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18

Bhandari, Uma, and Parveen Kumar. "Protective effect of Trigonella foenum-graecum Linn. on monosodium glutamate-induced dyslipidemia and oxidative stress in rats." Indian Journal of Pharmacology 45, no. 2 (2013): 136. http://dx.doi.org/10.4103/0253-7613.108288.

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19

Bansode, Twinkle, Amit Gupta, Sushama Chaphalkar, and B. Salalkar. "Integrating In-silico and In-vitro Approaches to Screen the Antidiabetic Drug from Trigonella foenum graecum Linn." International Journal of Biochemistry Research & Review 14, no. 3 (January 10, 2016): 1–10. http://dx.doi.org/10.9734/ijbcrr/2016/29875.

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20

Premanath, Ramya, N. Lakshmidevi, K. Jayashree, and R. N. Suresh. "Evaluation of anti-diabetic effect of Trigonella foenum graecum Linn. Leaf extract in streptozotocin induced diabetic rats." International Journal of Diabetes in Developing Countries 32, no. 3 (August 12, 2012): 138–44. http://dx.doi.org/10.1007/s13410-012-0081-3.

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21

Rose, Beena P. K., Anita K. Patel, and Asha K V. "A REVIEW ON METHIKA (TRIGONELLA FOENUM GRAECUM LINN): A WIDELY USED DRUG IN POSTNATAL CARE IN KERALA, INDIA." International Journal of Research in Ayurveda and Pharmacy 11, no. 3 (June 16, 2020): 61–63. http://dx.doi.org/10.7897/2277-4343.110361.

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22

Bhaumik, C., and P. P. C. Datta. "THE EFFECT OF N, P AND K DEFICIENCY ON TISSUE DIFFERENTIATION AND DIOSGENIN CONTENT IN TRIGONELLA FOENUM-GRAECUM LINN." Acta Horticulturae, no. 188 (June 1986): 221–24. http://dx.doi.org/10.17660/actahortic.1986.188.27.

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23

Kumar, Tarun, PShyamasakhi Devi, Priyotosh Banerjee, and NMeena Devi. "ANTICONVULSANT EFFECT OF ETHANOLIC EXTRACT OF TRIGONELLA FOENUM GRAECUM LINN. AND SODIUM VALPROATE - A COMPARATIVE STUDY IN ALBINO MICE." International Journal of Advanced Research 5, no. 11 (November 30, 2017): 350–54. http://dx.doi.org/10.21474/ijar01/5776.

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24

Vats, V., J. K. Grover, and S. S. Rathi. "Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats." Journal of Ethnopharmacology 79, no. 1 (February 2002): 95–100. http://dx.doi.org/10.1016/s0378-8741(01)00374-9.

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25

Singh, M., P. Mahala, T. V. Yadav, and B. L. Kakraliya. "Influence of Brassinolide in Mitigating the Adverse Effect of Drought on Yield Attributes in Fenugreek (Trigonella foenum-graecum Linn) Genotypes." International Journal of Current Microbiology and Applied Sciences 7, no. 06 (June 10, 2018): 1475–78. http://dx.doi.org/10.20546/ijcmas.2018.706.175.

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26

Hameed, Saleha, Ali Imran, Mehr un Nisa, Muhammad Sajid Arshad, Farhan Saeed, Muhammad Umair Arshad, and Muhammad Asif Khan. "Characterization of extracted phenolics from black cumin (Nigella sativa linn), coriander seed (Coriandrum sativum L.), and fenugreek seed (Trigonella foenum-graecum)." International Journal of Food Properties 22, no. 1 (January 1, 2019): 714–26. http://dx.doi.org/10.1080/10942912.2019.1599390.

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27

Ghayur, Muhammad Nabeel, Mohnad Abdalla, Asaad Khalid, Saeed Ahmad, and Anwarul Hassan Gilani. "Trigonella foenum-graecum Methanolic Extract on Isolated Smooth Muscles and Acetylcholinesterase Enzyme: An In Vitro and Mechanistic In Silico Investigation." BioMed Research International 2022 (April 5, 2022): 1–12. http://dx.doi.org/10.1155/2022/4849464.

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Background and Objective. Trigonella foenum-graecum Linn., also called fenugreek, is a popular medicinal plant cultivated all over the globe. Fenugreek seeds are known for their many medicinal properties. We present our findings on the effect of a 70% aqueous methanolic fenugreek seed extract (Tfg.Cr) on isolated GI smooth muscles (rabbit jejunum and rat ileum) and the effect of extract and its constituent diosgenin on acetylcholinesterase (AChE) enzyme. Results. When tested on the baseline of isolated tissues, Tfg.Cr was devoid of any activity (stimulant or relaxant) till 10 mg/ml. This is an interesting finding, keeping in mind that the fenugreek seeds are used to alleviate constipation and diarrhoea. When Tfg.Cr was tried for any potential AChE inhibitory activity, it did show an inhibitory effect in increasing concentrations (47-380 μg/ml). This inhibitory effect was comparable to the effect produced by a standard AChE inhibitor physostigmine. One of the known fenugreek constituents, diosgenin, was also tested, and it also showed an AChE inhibitory effect in a concentration-dependent manner (11-190 μg/ml). Interaction between diosgenin and AChE was further investigated by molecular docking and molecular dynamics simulations for 100 ns, which showed that diosgenin interacted with the active-site gorge of AChE through hydrophobic, pi-pi stacking, and hydrogen bonds with various amino acids of the AChE enzyme. Conclusion. The results show that the fenugreek extract does not possess any GI stimulant or relaxant activity even though it is used traditionally in GI motility disorders. The extract and diosgenin could inhibit the AChE enzyme pointing towards their benefit to enhance the memory.

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Ali, Nada M., Mazin A. Zamzami, and Samir M. Khoja. "Regulation of hepatic and mucosal 6-phosphofructo-1-kinase activity by trigonella foenum-graecum linn (fenugreek) seeds of streptozotocin-induced diabetic rats." Journal of Diabetes Research and Clinical Metabolism 2, no. 1 (2013): 18. http://dx.doi.org/10.7243/2050-0866-2-18.

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29

Nimbalkar, Vikram V., Ravina P. Shelke, Urmila E. Kadu, and Pandurang M. Gaikwad. "PROTECTIVE EFFECT OF DIOSGENIN AGAINST CARBON TETRACHLORIDE AND CISPLATIN INDUCED HEPATOTOXICITY IN RATS." International Journal of Clinical and Biomedical Research 4, no. 3 (July 31, 2018): 50–56. http://dx.doi.org/10.31878/ijcbr.2018.43.11.

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Background: Activation of hepatic stellate cells (HSC) plays central role in the development of liver fibrosis. In HSC activation, the transforming growth factor-β1 (TGF-β1) is considered to be the main stimuli factor. Diosgenin are the steroidal saponin and found in Trigonella foenum graecum Linn (Fenugreek) and some other species of Dioscorea. Diosgenin attenuates HSC activation by inhibiting transforming growth factor-β. Aim: In present study an attempt was made to explore the effect of diosgenin on liver fibrosis. Methods: Liver fibrosis was induced in rats by carbon tetrachloride (CCl4) 1 ml/kg intraperitoneally twice a week for 28 days and cisplatin 3mg/kg intraperitoneally at 0, 1, 3 week for 4 weeks. The extent of liver fibrosis was assessed by measuring the weight of liver and levels of total bilirubin (TBL), hydroxyproline (HP) and serum enzymes due to deposition of extracellular matrix (ECM). Results: The administration of diosgenin reduced the liver weight of CCl4 and cisplatin treated animals and reduced the TBL, HP level and serum enzymes significantly and inhibited liver fibrosis induced by CCl4 and cisplatin. Conclusion: The result obtained in the present investigation, Diosgenin treatment exerted significant hepatoprotective effect in animals by inhibiting ECM deposition and HSCs activation.

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30

Nursanti, Okta, Dayu Liandra, Ginayanti Hadisoebroto, and Dytha Andri Deswati. "MOLEKULER DOCKING TERHADAP RESEPTOR PEROXISOME PROLIFERATOR-ACTIVED RECEPTOR-GAMMA (PPAR-y) SEBAGAI ANTIDIABETES." Medical Sains : Jurnal Ilmiah Kefarmasian 8, no. 1 (March 1, 2023): 315–24. http://dx.doi.org/10.37874/ms.v8i1.521.

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Diabetes mellitus (DM) merupakan penyakit kronik yang muncul baik ketika pancreas tidak mampu memproduksi cukup insulin ataupun ketika tubuh tidak dapat menggunakan insulin yang diproduksi secara efektif tanaman atau tumbuhan telah banyak digunakan oleh masyarakat sebagai pencegah serta pengobatan penyakit diabetes dan juga sebagai suplemen kesehatan. Di dalam nya terkandung senyawa-senyawa yang dapat berperan sebagai obat antidiabetes. Salah satu reseptor yang berperan dalam pengobatan diabetes adalah Peroxisome Proliferator-Actived Receptor-Gamma (PPAR-y) yang bertanggung jawab terhadap sensitisasi insulin dalam jaringan adiposa. Dalam penelitian ini, interaksi antara senyawa-senyawa dalam tanaman paitan (Tithonia diversifolia), klabet (Trigonella foenum-graecum Linn), daun salam (Syzygium polyanthum), mengkudu (Morinda citrifolia, L), dan lidah buaya (Aloe vera) sebagai ligan, dengan PPAR-y diamati menggunakan perangkat lunak Arguslab, merupakan suatu program yang dapat menambatkan molekul ligan pada makromolekul reseptor. Perangkat lunak penambatan molekul yang digunakan adalah Arguslab versi 4.0.1 Dari hasil penambatan molekul (Molecular Docking) menunjukan bahwa senyawa-senyawa digunakan aman dan lolos dari uji ADMET, Binding Energy delapan ligan tersebut lebih besar dibandingkan ligan alami pioglitazone pada RMSD < 2 Angstrom, tetapi ada satu ligan yang binding energy nya mendekati pioglitazone yaitu lycine dengan nilai binding energy -7.34728 Kcal/mol. Kata kunci : Diabetes, PPAR-y, Penambatan molekul, Arguslab, Daun paitan

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31

Journal, Baghdad Science. "Study of Cytotoxic Effect of Aqueous Extract Fenugreek(Trigonella Foenum Graecum L.S) Seeds and The New Complexes of Rh (?) and Pd (?) on Cancer Cell Lines." Baghdad Science Journal 9, no. 2 (December 11, 2018): 289–95. http://dx.doi.org/10.21123/bsj.9.2.289-295.

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The effect of the aqueous extract of fenugreek seeds (Trigonella Foenum Graecum L.), Rhodium complex (?) with formula [RhL2CLH2O].1 1/2 ETOH and palladium (?) [pdl2].2ETOH,where L=2-hydroxy phenyl piperonalidine was studied on two cancer cell lines. The first cell line was intestine cancer of female albino mice (L20B), the second one was Rhabdomysarcomas (RD)cell line in human. The activity of the new complexes and the aqueous extract was compared to the well-known anticancer drug (cis-platin) by utilizing the in vitro system. The cell lines were treated with four concentrations of cis-platin 31.25,62.5,125 and 250 ?g/ml for 72 hour exposure time. The same concentrations were used with extract and the new complexes. This study showed that the aqueous extract, Rhodium (?) and palladium (?) complexes have a promising anticancer cell activity as noticed from their effect on inhibition of the cancer cells . Inhibition rate was increased with concentration for the three treatments and it was found to be significant differences (p

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32

Journal, Baghdad Science. "Comparison of The Effect of Aqueous Extracts of two Plants, Origanum Vulgare L. and Fenugreek Seeds with Anticancer Drug Cis-Platin on the Growth of Cancer Cell Lines." Baghdad Science Journal 10, no. 2 (June 2, 2013): 368–76. http://dx.doi.org/10.21123/bsj.10.2.368-376.

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This study involved the effect of the aqueous extracts of two plants, Origanum vulgare L.(1), Trigonella Foenum Graecum L. (Fenugreek) seeds(2) on the growth of cancer cell lines. Rhabdomyo sarcomas (RD) of human cell line and female intestine cells of Albino mice (L20B) in vitro System. These extracts were compared with the known anticancer drug Cis-platinum(Cis-Pt) as a positive control. The phytochemical tests were used for screening the active compounds in plants. The inhibition activity assay was used as a parameter of the cytotoxic effect of these extracts. Cancer cell lines were treated with four concentrations of Cis-platin, 31.25, 62.5, 125 and 250 ?g/ml for 72 hour exposure time. The same concentrations were used for the other extracts. This study found that the two aqueous extracts (1,2) have a cytotoxic effects on cancer cells as could be seen from their effects on inhibition percentage and the significant differences (p

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Hussain, Jinan, Iman Hashim, Farooq Ibrahem Mohammed, Ashgan Salman, and Noora Saad. "Comparison of The Effect of Aqueous Extracts of two Plants, Origanum Vulgare L. and Fenugreek Seeds with Anticancer Drug Cis-Platin on the Growth of Cancer Cell Lines." Baghdad Science Journal 10, no. 2 (June 2, 2013): 368–76. http://dx.doi.org/10.21123/bsj.2013.10.2.368-376.

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This study involved the effect of the aqueous extracts of two plants, Origanum vulgare L.(1), Trigonella Foenum Graecum L. (Fenugreek) seeds(2) on the growth of cancer cell lines. Rhabdomyo sarcomas (RD) of human cell line and female intestine cells of Albino mice (L20B) in vitro System. These extracts were compared with the known anticancer drug Cis-platinum(Cis-Pt) as a positive control. The phytochemical tests were used for screening the active compounds in plants. The inhibition activity assay was used as a parameter of the cytotoxic effect of these extracts. Cancer cell lines were treated with four concentrations of Cis-platin, 31.25, 62.5, 125 and 250 ?g/ml for 72 hour exposure time. The same concentrations were used for the other extracts. This study found that the two aqueous extracts (1,2) have a cytotoxic effects on cancer cells as could be seen from their effects on inhibition percentage and the significant differences (p

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Zahra, Kaenat, Dr Abdull, and Dr Razia Shaheen. "Clinical Efficacy of Hulba (Trigonella foenum graecum Linn.) and Dry Cupping (Hijamat Bila Shurt) in the Management of Primary Dysmenorrhoea (Usre Tams Ibtidae) ’." American Journal of PharmTech Research 9, no. 6 (December 8, 2019): 175–90. http://dx.doi.org/10.46624/ajptr.2019.v9.i6.014.

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Tiwari, Gaurav, and Ruchi Tiwari. "Assessment of Nutraceutical Potential of Herbs for Promoting Hair Growth: Formulation Considerations of Herbal Hair Oil." Open Dermatology Journal 15, no. 1 (December 31, 2021): 78–83. http://dx.doi.org/10.2174/1874372202115010078.

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Background: Hair loss is a relatively common occurrence that causes concern in people of all ages. In most cases, hair loss is permanent, but it can lead to alopecia. Hair root activation is necessary to improve hair development and prevent hair loss. Herbal cosmetics are increasingly widely used by the general public due to the concept of fewer adverse effects and a higher level of safety and security. Objective: The primary goal of this study is to prepare and evaluate herbal hair oil made from fresh components of various plants. Methods: Herbs were acquired from Pranveer Singh Institute of Technology's medicinal garden. Herbs were collected, dried, then ground in a mortar and pestle. Grinded herbs (Murraya koenigii, Hibiscus rosa-sinensis Linn., Nigella sativa, Trigonella foenum-graecum) were combined with 60% Cocos nucifera oil, heated, cooled, and filtered. Physical appearance, viscosity, pH, sensitivity test, hair growth activity, hair weight, antimicrobial test, stability test, and other criteria were determined and are reported in this text for the created herbal hair oil. Results: Herbal hair oil was odourless and reddish brown in appearance. Herbal hair oil had an appropriate refractive index, pH, saponification value, and specific gravity. After application, the herbal oil demonstrated Newtonian flow, as well as good hair growth and weight, with no irritation. Phytochemical screening showed the presence of ascorbic acid, sulphur and saponins. The formulation was found to be stable for 30 days. Conclusion: Conclusively, combination of effective herbs could be used to improve hair growth.

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Agustini, Kurnia, Michael Wink, Wahono Sumaryono, Frans Suyatna, and Nurjati Chairani Siregar. "TRIGONELLA FOENUM-GRAECUM L. EXHIBITS ESTROGENIC EFFECT THROUGH PRESENILIN 2 GENE EXPRESSION IN THE BREAST CANCER CELL LINE MCF-7." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (January 7, 2019): 438. http://dx.doi.org/10.22159/ajpcr.2018.v12i1.29340.

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Objective: The objective of this study is to investigate the estrogenic and antiestrogenic activity of Fenugreek seeds, Trigonella foenum-graecum L. in the estrogen-dependent breast cancer cell line, MCF-7, including its effect on the expression of estrogen-dependent presenilin 2 (pS2) gene.Methods: An activity guided fractionation was carried out with extracts from fenugreek seeds in MCF-7 cells. Cytotoxic activity assays were conducted with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. Most fractions were also tested also tested in media with estradiol 10 nM We also analysed the expression of pS2 gene. For the analysis of pS2 gene expression we employed PCR primers for pS2 and for β-actin as a housekeeping gene using real-time polymerase chain reaction (RT-PCR).Results: Based on cytotoxic activity assay in MCF-7, the active fractions are ethyl acetic fraction and its phases ethyl acetic (EA) 2 and EA 2.2. The most active fraction was EA 2.2 (IC50=27.129 ppm), which exhibited a biphasic effect; at low concentrations, it stimulated the growth, and at high concentrations it showed strong cytotoxic effects. EA2.2 fraction in concentration 20 ppm, also could induce pS2 gene expression in media with and without estrogen.Conclusion: The most active fraction was the ethyl acetate phase and further subfractions. The most active fraction also induced the expression of pS2 gene which was studied by RT-PCR.

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Wink, Michael, Wahono Sumaryono, Frans Suyatna, and Nurjati Chairani Siregar. "TRIGONELLA FOENUM-GRAECUM L. EXHIBITS ESTROGENIC EFFECT THROUGH PRESENILIN 2 GENE EXPRESSION IN THE BREAST CANCER CELL LINE MCF-7." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (January 7, 2019): 438. http://dx.doi.org/10.22159/ajpcr.2019.v12i1.29340.

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Objective: The objective of this study is to investigate the estrogenic and antiestrogenic activity of Fenugreek seeds, Trigonella foenum-graecum L. in the estrogen-dependent breast cancer cell line, MCF-7, including its effect on the expression of estrogen-dependent presenilin 2 (pS2) gene.Methods: An activity guided fractionation was carried out with extracts from fenugreek seeds in MCF-7 cells. Cytotoxic activity assays were conducted with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. Most fractions were also tested also tested in media with estradiol 10 nM We also analysed the expression of pS2 gene. For the analysis of pS2 gene expression we employed PCR primers for pS2 and for β-actin as a housekeeping gene using real-time polymerase chain reaction (RT-PCR).Results: Based on cytotoxic activity assay in MCF-7, the active fractions are ethyl acetic fraction and its phases ethyl acetic (EA) 2 and EA 2.2. The most active fraction was EA 2.2 (IC50=27.129 ppm), which exhibited a biphasic effect; at low concentrations, it stimulated the growth, and at high concentrations it showed strong cytotoxic effects. EA2.2 fraction in concentration 20 ppm, also could induce pS2 gene expression in media with and without estrogen.Conclusion: The most active fraction was the ethyl acetate phase and further subfractions. The most active fraction also induced the expression of pS2 gene which was studied by RT-PCR.

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Kartal, Sevtap, Zeynep Baturay, and Lale Efe. "Effect of Planting Times on the Yield and Quality of Fenugreek (Trigonella Foenum-Graecum L.) Under the Conditions of Kahramanmaraş." Turkish Journal of Agriculture - Food Science and Technology 11, no. 2 (February 28, 2023): 296–302. http://dx.doi.org/10.24925/turjaf.v11i2.296-302.5662.

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This study was performed in the 2013-2014 cultivation season with the purpose of determining the most suitable planting season of fenugreek under the ecological conditions of Kahramanmaraş. The trial was established in two different cultivation periods as winter and spring at the Eastern Mediterranean Transition Zone Agricultural Research Station in according to factorial randomized block design with three replications. In the study, the Gürarslan fenugreek variety as well as Candicate Line-1 and Genotype-1 fenugreek genotypes were used as material. In the study, features such as plant height, first pod height, number of branches per plant, pod length, number of pods per plant, number of seeds per pod, seed yield per plant, seed yield per decare, thousand seed weight, mucilage rate, fixed oil ratio, fixed oil yield, crude protein ratio, humidity, raw ash ratio, and the rates of linoleic acid, alpha linoleic acid, oleic acid, palmitic acid, stearic acid as important fatty acids were studied. Variance analysis made on the data obtained by using SPSS statistical package program. In the comparison of the means, Duncan multiple comparison test was used. As a result, in this study, was found that in the region where the study was performed, the most suitable planting season for fenugreek cultivators is the winter planting dated winter planting when the highest values of plant height, number of pods per plant, seed yield per plant were obtained. From the features studied in the research the difference between genotypes was found significant only from the perspective of seed yield per plant and fixed oil ratio. While the best results were obtained from Genotype-1 for seed yield per plant, the best results for fixed oil yield were obtained from Candicate Line-1.

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Chadchan, Kailash S., Swastika N. Das, Jameel G. Jargar, and Kusal K. Das. "A Comparative Study on Anti-diabetic Effects of Aqueous Trigonella foenum graecum, Hibiscus cannabinus Linn, and Cicer arietinum extracts on Alloxan Induced Diabetic Male Albino Rats." Journal of Young Pharmacists 9, no. 2 (April 5, 2017): 230–33. http://dx.doi.org/10.5530/jyp.2017.9.45.

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İnanan, Burak Evren, and Mahir Kanyılmaz. "Kakule, Ayçiçeği ve Çemen Otu Tohumları Ekstraktlarının Sazan Balığı (Cyprinus carpio L.) Sperm Motilitesine ve Oksidatif Strese In Vitro Etkileri." Turkish Journal of Agriculture - Food Science and Technology 8, no. 1 (January 31, 2020): 214. http://dx.doi.org/10.24925/turjaf.v8i1.214-219.2974.

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The aim of the present study is to assess the effects Fenugreek (Trigonella foenum-graecum, Fabaceae), sunflower (Helianthus annuus, Asteraceae), green cardamom (Elettaria cardamomum, Zingiberaceae) and seed extracts, which they belonged to three different plant families, on common carp (Cyprinus carpio L.) spermatozoa motility parameters and oxidative stress conditions. For this reason, sperm samples treated with seed extracts at the ratios of 0.1%, %0.5, 1%, and 2%, were incubated at 4°C and sampled at 2nd and 48th hours. Among sperm motility parameters, curvilinear velocity (VCL), average path velocity (VAP), straight-line velocity (VSL), straightness STR), linearity (LIN), and wobble (WOB) were determined by computer-assisted sperm analysis (CASA). According to the results, sunflower and green cardamom seed extracts have attenuated motility parameters at all tested concentrations. However, motility parameters measured in %0.5 of fenugreek seed extract were higher than all other groups including the control at 48th hour. Also, TBARS values as an oxidative stress indicator in this group were decreased. 2% of all seed extracts had negative effects on the sperm samples. Particularly, 2% sunflower seed extract caused the higher oxidative stress. These results indicate that fenugreek seed extract is more proper for the maintenance of common carp spermatozoa at 4°C, comparing to those of sunflower and green cardamom.

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Gupta, Piyush, Nagendra Chauhan, and Anupam Pathak. "Effect of <i>Trigonella foenum-graecum</i> Linn. (seeds) and <i>Butea monosperma</i> Lam. (flowers) on chemotherapy-induced alopecia." Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery 3, no. 3 (2013): 121. http://dx.doi.org/10.5455/spatula.20130909073404.

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Rehan S., Ahmad, Dutta Sumana, and Shamsi Intikhab Alam. "A Systematic Investigation of Trigonelline, Diosgenin, Protodioscin, and Dioscin from Trigonella foenum-graecum (fenugreek seeds) has Anti-cancer and Antioxidant Properties Without Side Effects." International Journal of Zoological Investigations 08, no. 02 (2022): 404–18. http://dx.doi.org/10.33745/ijzi.2022.v08i02.050.

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Systematic review and meta-analysis criteria were used to plan and conduct this systematic review (PRISMA). Different literature of reviews explicit that Fibers, flavonoids, polysaccharides, and saponins are the principal chemical components of Trigonella foenum-graecum. Some of the components may have mitogenic actions, which result in immune-competent cells being restored. Some of these ingredients are also antioxidants and may have immune-stimulant characteristics. In vitro, the extract from the seeds of the fenugreek seed was found to be cytotoxic to numerous cancers, including T-cell lymphoma, but not to normal cells. Breast, pancreatic, and prostate cancer cell lines showed growth inhibition after being treated with a specific amount of the extract. Diosgenin suppressed MCF-7 cell proliferation in a dose-dependent manner, according to in vitro tests. Diosgenin's effect on a human mammary carcinoma cell line, as well as its therapeutic potential for N-nitroso-N-methyl urea-induced breast cancer. Fenugreek extracts and their isolated constituents have been revealed to have anti-cancer activities in several investigations. Trigonelline, Diosgenin, Protodioscin, and Dioscin were found to be the most potent anticancer ingredients in fenugreek. Furthermore, fenugreek seeds are high in many essential chemicals, which show asignificant role in the suppression and inhibition of various malignancies. In addition, studies on the estrogenic effects of fenugreek seeds in vitro and in vivo have demonstrated its potential as an HRT alternative.

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Naik, Archana, Chhaya Gadgoli, Nikita Patil, and Ruchira Salunkhe. "Simultaneous Estimation for Diosgenin, Charantin and Hydroxychalcone from Herbal Antidiabetic Formulation using Validated HPTLC Method." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 03 (September 25, 2023): 612–17. http://dx.doi.org/10.25258/ijpqa.14.3.26.

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Most antidiabetic polyherbal preparations contain Trigonella foenum-graecum, Momordica charantia and Cinnamomum zeylanicum as active components. Although all ingredients are popular as antidiabetic agents, but the analytical method is not available for simultaneous estimation of marker compounds from herbal formulations due to several challenges. Hence, the HPTLC method was developed for simultaneous estimation of three active phytoconstituents viz. diosgenin, charantin and hydroxychalcone in polyherbal formulation. The stationary phase of the optimized HPTLC method is silica gel 60 GF254 and the mobile phase is chloroform: glacial acetic acid: methanol: water (4:3:2:1v/v). The Rf value of phytoconstituents charantin, diosgenin, and hydroxychalcone was found to be 0.72, 0.61 and 0.30 at detection wavelength 342 nm. According to ICH criteria, the analytical method validation was performed. All three markers showed linear and proportional responses in the 400 to 1400 ng/band range, which confirmed the markers’ linearity. Precision measurements were made at the intraday and interday levels, and the results were satisfactory and in line with the specifications. Accuracy was determined by the recovery method and %recovery was found to be in the range of 85.20 to 97.19. The validated HPTLC method was utilized to analyze the marketed Quanto Diab Forte capsule formulation containing charantin, diosgenin, and hydroxychalcone. The proposed validated analytical method was found to be simple, precise and accurate.

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Paul, Santanu, and Debarupa Hajra. "Study of glucose uptake enhancing potential of fenugreek (Trigonella foenum graecum) leaves extract on 3T3 L1 cells line and evaluation of its antioxidant potential." Pharmacognosy Research 10, no. 4 (2018): 347. http://dx.doi.org/10.4103/pr.pr_50_18.

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Hind, Brogi, Moumen Zineb, Hajji Elbachir, EL Amrani Najat, Amsaguine Siham, and Radallah Driss. "Evaluation of potential effects of the aqueous extract of fenugreek seeds on fertility in male rats." Journal of Ayurvedic and Herbal Medicine 3, no. 4 (December 30, 2017): 210–15. http://dx.doi.org/10.31254/jahm.2017.3408.

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Fenugreek (Trigonella foenum-graecum L.) has long been used as a medicinal plant for the treatment of nutritional and metabolic dysfunctions. It has been shown that the daily intake of fenugreek seeds improves feeding behavior in animals. A number of studies have also suggested a link between Fenugreek seeds extracts and fertility but have yielded contradictory results. In this paper, particular attention has been paid to the impact of consumption of the aqueous extract of fenugreek seeds, prepared according to the traditional Moroccan method, on the spermatic parameters and the pathophysiology of the reproductive system of Wistar rats receiving 450 and 900 mg / kg /day, respectively. Our study results show the benefits of fenugreekseeds aqueous extract, used in the traditional Moroccan pharmacopoeia on appetite stimulation and weight gain without any significant impact on the fertility and the reproductive performances. Both quantitative and qualitative analysis of sperm parameters (morphology, mobility and vitality) showed no significant variation compared to the controls. In addition, histological examination of seminiferous tubules and reproductive accessory glands (prostate and seminal vesicles) in fenugreek treated rats showeda normal tissue architecture without visible lesion. These data exclude all potential risks from the consumption of aqueous extract of fenugreek seeds on the fertility and reproductive function in male rats. However, taking into account other data from the literature, this regular consumption should be closely monitored in order to allow the organism to fully benefit from a multiple phytotherapeutic virtues of this plant.

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Elghazaly, Nawal A., Hala H. Zaatout, Eman H. Radwan, Mohamed M. Elghazaly, and Eman A. Elsheikha. "Trigonella Foenum Graecum Extract Benefits on Hematological, Biochemical and Male Reproductive System of as a Complementary Therapy with Glimepiride in Treating Streptozotocin Induced Diabetic Rats." Journal Of Bioinformatics And Diabetes 1, no. 3 (February 22, 2019): 45–59. http://dx.doi.org/10.14302/issn.2374-9431.jbd-19-2613.

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Diabetes mellitus (DM) is a chronic metabolic disorder. Streptozotocin is a naturally occurring cytotoxic chemical, particularly toxic to the pancreas and insulin producing beta cells in mammals and induces diabetes. Glimepiride is a second generation sulfonylurea, used as second-line or add-on treatment options for type 2 diabetes. Fenugreek (Trigonellafoenum graecum) seeds have been documented as a traditional plant treatment for diabetes. Soluble dietary fiber of Fenugreek significantly improved oral glucose tolerance in diabetic rats. It also exerts anti-diabetic effects mediated through the inhibition of carbohydrate digestion and absorption and the enhancement of peripheral insulin action. Most herbal remedies can interact with allopathic drugs resulting in altered activity and toxicity. At the same time, herbal remedies might produce the same kind of effects as the drug produce. Current published research information on herb-drug interactions is scanty. So, the aim of this study was to investigate the possible interaction between conventional drug used for the management of diabetes; (Glimepiride) and a traditional herbal remedy; Fenugreek aqueous extract in Streptozotocin induced diabetic male albino rats. In conclusion, combination therapy induces better hematological, biochemical effects and improves the oxidative stress biomarkers and antioxidant enzymes. Histological studies showed better results on some organ functions. The results emphasize the benefit of using the combination of Fenugreek seeds aqueous extracts as supportive complementary anti-diabetic therapy.

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Salam, Shaimaa G. Abdel, Mohamed M. Rashed, Nabih A. Ibrahim, Emam A. Abdel Rahim, Hadeil Muhanna Alsufiani, Rasha A. Mansouri, Mohamed Afifi, and Ammar Al-Farga. "Cell Growth Inhibition, DNA Fragmentation and Apoptosis-Inducing Properties of Household-Processed Leaves and Seeds of Fenugreek (Trigonella Foenum-Graecum Linn.) against HepG2, HCT-116, and MCF-7 Cancerous Cell Lines." Current Issues in Molecular Biology 45, no. 2 (January 19, 2023): 936–53. http://dx.doi.org/10.3390/cimb45020060.

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Household processing of fenugreek seeds and leaves, including soaking, germination, and boiling of the seeds, and air-drying of the leaves, has improved the levels of human consumption of the bitter seeds and increased the shelf life of fresh leaves, respectively. The potential anticancer activity of either unprocessed or processed fenugreek seeds or leaves and the relative expression of pro-apoptotic and anti-apoptotic genes of the studied cancerous cell lines exposed to IC50 crude extracts was investigated to observe the apoptotic-inducing property of this plant as an anticancer agent. The protein expression of IKK-α and IKK-β, as inhibitors of NF-KB which exhibit a critical function in the regulation of genes involved in chronic inflammatory disorders, were studied in the tested cancerous cell lines. In this study, the anticancer activity of household-processed fenugreek leaves and seeds against HepG2, HCT-116, MCF-7, and VERO cell lines was measured using an MTT assay. DNA fragmentation of both HepG2 and MCF-7 was investigated by using gel electrophoresis. RT-PCR was used to evaluate the relative expression of each p53, caspase-3, Bax, and Bcl-2 genes, whereas ELISA assay determined the expression of caspase-3, TNF-α, and 8-OHDG genes. Western blotting analyzed the protein-expressing levels of IKK-α and IKK-β proteins in each studied cell line. Data showed that at 500 µg mL−1, ADFL had the highest cytotoxicity against the HepG2 and HCT-116 cell lines. Although, each UFS and GFS sample had a more inhibitory effect on MCF-7 cells than ADFL. Gel electrophoresis demonstrated that the IC50 of each ADFL, UFS, and GFS sample induced DNA fragmentation in HepG2 and MCF-7, contrary to untreated cell lines. Gene expression using RT-PCR showed that IC50 doses of each sample induced apoptosis through the up-regulation of the p53, caspase-3, and Bax genes and the down-regulation of the Bcl-2 gene in each studied cell line. The relative expression of TNF-α, 8-OHDG, and caspase-3 genes of each HepG2 and MCF-7 cell line using ELISA assays demonstrated that ADFL, UFS, and GFS samples reduced the expression of TNF-α and 8-OHDG genes but increased the expression of the caspase-3 gene. Protein-expressing levels of IKK-α and IKK-β proteins in each studied cell line, determined using Western blotting, indicated that household treatments decreased IKK-α expression compared to the UFS sample. Moreover, the ADFL and SFS samples had the most activity in the IKK-β expression levels. Among all studied samples, air-dried fenugreek leaves and unprocessed and germinated fenugreek seeds had the most anti-proliferative and apoptotic-inducing properties against human HepG2, MCF-7, and HCT-116 cell lines, as compared to the VERO cell line. So, these crude extracts can be used in the future for developing new effective natural drugs for the treatment of hepatocellular, breast, and colon carcinomas.

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Chrubasik-Hausmann, Sigrun. "Bockshornklee (Trigonella foenum-graecum)." Zeitschrift für Komplementärmedizin 12, no. 05 (September 2020): 54–56. http://dx.doi.org/10.1055/a-1228-2074.

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Brendieck-Worm, Cäcilia. "Bockshornklee, Trigonella foenum-graecum." Zeitschrift für Ganzheitliche Tiermedizin 29, no. 04 (November 12, 2015): 111–17. http://dx.doi.org/10.1055/s-0035-1558147.

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Susilowati, Retno, and Ulfa Maynisa Rohmanningrum. "Effective Combination of Nigella sativa and Trigonella foenum-graecum Seed Extract on Wound Healing in Diabetic Mice." Jurnal Biodjati 8, no. 1 (May 30, 2023): 106–16. http://dx.doi.org/10.15575/biodjati.v8i1.19968.

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High levels of free radicals in diabetic wounds often cause chronic inflammation. Nigella sativa and Trigonella foenum-graecum seed extracts are rich in antioxidants and have anti-inflammatory effects. Trigonella foenum-graecum seed extracts can also accelerate the reepithelialization process in wound healing. This study aimed to determine the combination of ethanol extract of Nigella sativa and Trigonella foenum-graecum seeds on wound length and the number of neutrophils, macrophages, fibroblasts, and collagen density in the incision wound of diabetic mice induced by streptozotocin. T. This study used three types of controls, namely Normal (Normal mice, HPMC 3%), DM (Diabetic mice, HPMC 3%), and Iodine (Diabetic mice, Povidone Iodine 10%). Topical treatment with 70% ethanol extract ointment combined with Nigella sativa and Trigonella foenum-graecum in various variations, namely N (20%:0%), T (0%:10%), NT (10%:5%), Observations of the wound healing process were carried out on 3rd, 7th and 14th day. Data were analyzed using the One Way ANOVA and Duncan Multiple Range Test. The study's results by observing the morphology of the wound length on day 7th day showed that the combination treatment of extracts of Nigella sativa and Trigonella foenum-graecum resulted in the shortest wound, which was significantly different from the wound in untreated diabetic mice. In addition, diabetic wounds without treatment showed infection, and on the contrary, the infection did not occur in wounds treated with a combination of extracts of Nigella sativa and Trigonella foenum-graecum. The results of wound histology observations showed that the combination treatment of extracts of Nigella sativa and Trigonella foenum-graecum showed a decrease in inflammation which was indicated by a significant decrease in the number of neutrophil cells, macrophages, and accelerated reepithelialization of wound healing as indicated by a significant increase in the number of fibroblasts and collagen density since the third day of treatment.

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