Log in

Relevant bibliographies by topics / TRIAZOLO-TRIAZINE / Journal articles

Journal articles on the topic 'TRIAZOLO-TRIAZINE'

To see the other types of publications on this topic, follow the link: TRIAZOLO-TRIAZINE.

Author: Grafiati

Published: 1 April 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'TRIAZOLO-TRIAZINE.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Wang, Qian, Yanli Shao, and Ming Lu. "Amino-tetrazole functionalized fused triazolo-triazine and tetrazolo-triazine energetic materials." Chemical Communications 55, no. 43 (2019): 6062–65. http://dx.doi.org/10.1039/c9cc01777a.

Full text

Abstract:

In this study, two insensitive energetic compounds using fused triazolo-triazine and tetrazolo-triazine as the framework, one amino and one tetrazole as functional groups, were prepared through a two-step reaction.

APA, Harvard, Vancouver, ISO, and other styles

2

Pathak, Suraj Kumar, Yepeng Xiang, Manli Huang, Taian Huang, Xiaosong Cao, He Liu, Guohua Xie, and Chuluo Yang. "Fused tetracyclic tris[1,2,4]triazolo[1,3,5]triazine as a novel rigid electron acceptor for efficient thermally activated delayed fluorescence emitters." RSC Advances 10, no. 26 (2020): 15523–29. http://dx.doi.org/10.1039/d0ra01925a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Zeng, Qun, Yanyang Qu, Jinshan Li, and Hui Huang. "Theoretical studies on the derivatives of tris([1,2,4]triazolo)[4,3-a:4′,3′-c:4′′,3′′-e][1,3,5]triazine as high energetic compounds." RSC Advances 6, no. 7 (2016): 5419–27. http://dx.doi.org/10.1039/c5ra22524h.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Navarro, Amparo, M. Paz Fernández-Liencres, Gregorio García, José M. Granadino-Roldán, and Manuel Fernández-Gómez. "A DFT approach to the charge transport related properties in columnar stacked π-conjugated N-heterocycle cores including electron donor and acceptor units." Physical Chemistry Chemical Physics 17, no. 1 (2015): 605–18. http://dx.doi.org/10.1039/c4cp04220d.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Bernat, Zofia, Anna Szymanowska, Mateusz Kciuk, Katarzyna Kotwica-Mojzych, and Mariusz Mojzych. "Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives." Molecules 25, no. 17 (August 29, 2020): 3948. http://dx.doi.org/10.3390/molecules25173948.

Full text

Abstract:

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.

APA, Harvard, Vancouver, ISO, and other styles

6

Hojo, Ryoga, Don M. Mayder, and Zachary M. Hudson. "Donor–acceptor materials exhibiting deep blue emission and thermally activated delayed fluorescence with tris(triazolo)triazine." Journal of Materials Chemistry C 9, no. 40 (2021): 14342–50. http://dx.doi.org/10.1039/d1tc03480d.

Full text

Abstract:

Five emitters with the tris(triazolo)triazine acceptor core are reported, with emission from deep blue to green. These emitters show promising thermally activated delayed fluorescence and/or two-photon fluorescence properties.

APA, Harvard, Vancouver, ISO, and other styles

7

Hojo, Ryoga, Don M. Mayder, and Zachary M. Hudson. "Donor–acceptor materials exhibiting deep blue emission and thermally activated delayed fluorescence with tris(triazolo)triazine." Journal of Materials Chemistry C 9, no. 40 (2021): 14342–50. http://dx.doi.org/10.1039/d1tc03480d.

Full text

Abstract:

Five emitters with the tris(triazolo)triazine acceptor core are reported, with emission from deep blue to green. These emitters show promising thermally activated delayed fluorescence and/or two-photon fluorescence properties.

APA, Harvard, Vancouver, ISO, and other styles

8

Hundemer, Fabian, Ettore Crovini, Yoshimasa Wada, Hironori Kaji, Stefan Bräse, and Eli Zysman-Colman. "Tris(triazolo)triazine-based emitters for solution-processed blue thermally activated delayed fluorescence organic light-emitting diodes." Materials Advances 1, no. 8 (2020): 2862–71. http://dx.doi.org/10.1039/d0ma00659a.

Full text

Abstract:

We report a new emitter 3,4,5-3TCz-TTT based on a tris(triazolo)triazine acceptor that shows thermally activated delayed fluorescence and cross-compare its performance with the recently reported analogue, 3DMAC-TTT.

APA, Harvard, Vancouver, ISO, and other styles

9

Fang, Zhou, Shengyue Wang, Junxu Liao, Xinrui Chen, Yuanyuan Zhu, Weiguo Zhu, and Yafei Wang. "Asymmetric sky-blue thermally-activated delayed fluorescence emitters bearing tris(triazolo)triazine moiety for solution-processable organic light-emitting diodes." Journal of Materials Chemistry C 10, no. 12 (2022): 4837–44. http://dx.doi.org/10.1039/d1tc05372h.

Full text

Abstract:

Two sky-blue TADF emitters bearing the tris(triazolo)triazine acceptor moiety were designed and synthesized. The solution-processed OLEDs based on these two emitters achieved a maximum EQE of 10.01% at 474 nm.

APA, Harvard, Vancouver, ISO, and other styles

10

Anikin, Oleg V., Nikita E. Leonov, Michael S. Klenov, Aleksandr M. Churakov, Alexey A. Voronin, Nikita V. Muravyev, Yurii A. Strelenko, Ivan V. Fedyanin, and Vladimir A. Tartakovsky. "An Energetic (Nitro-NNO -azoxy)triazolo-1,2,4-triazine." European Journal of Organic Chemistry 2019, no. 26 (June 13, 2019): 4189–95. http://dx.doi.org/10.1002/ejoc.201900314.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Molina, Pedro, Mateo Alajar地, Ma Jes徭 P屍ez de Vega, and Antonio L用ez. "Preparation of [1,2,4]Triazolo[5,1-c][1,2,4]triazine Derivatives from 3,4-Diamino[1,2,4]triazine." HETEROCYCLES 29, no. 8 (1989): 1607. http://dx.doi.org/10.3987/com-89-5056.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Piercey, Davin G., David E. Chavez, Brian L. Scott, Greg H. Imler, and Damon A. Parrish. "An Energetic Triazolo-1,2,4-Triazine and its N-Oxide." Angewandte Chemie International Edition 55, no. 49 (November 9, 2016): 15315–18. http://dx.doi.org/10.1002/anie.201608723.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Piercey, Davin G., David E. Chavez, Brian L. Scott, Greg H. Imler, and Damon A. Parrish. "An Energetic Triazolo-1,2,4-Triazine and its N-Oxide." Angewandte Chemie 128, no. 49 (November 9, 2016): 15541–44. http://dx.doi.org/10.1002/ange.201608723.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Abdel-Rahman, Reda M., Abdulrahman S. Alharbi, Nawaa A. Alshammari, and Yousuf O. Adnan. "Design, Synthesis and Molluscicidal Activity of New Phosphorus Compounds Bearing Fluorine Substituted 1,2,4-Triazolo[3,2-c][1,2,4]triazine Derivatives." Letters in Organic Chemistry 17, no. 3 (February 19, 2020): 184–90. http://dx.doi.org/10.2174/1570178616666190718120953.

Full text

Abstract:

Novel phosphorus compounds bearing fluorine substituted 1,2,4-triazolo[3,2-c][1,2,4]triazine derivatives have been synthesized, starting from ring closure reactions of 3-hydrazino-4-(4`- fluorophenyl)-5-(prydin-4`-yl)-1,2,4-trizole (4) with 1,2-bioxygen compounds followed by the treatment with functional phosphorus compounds. The new systems obtained were evaluated as molluscicidal targets against some snails. Structures of these targets were elucidated upon their elemental and spectral data.

APA, Harvard, Vancouver, ISO, and other styles

15

Heravi, Majid M., Naser Montazeri, Mohammad Rahimizadeh, Mehdi Bakavoli, and Mitra Ghassemzadeh. "Synthesis of 1,2,4-triazolo[1,5-d]-1,2,4-triazine-5-thiones." Journal of Heterocyclic Chemistry 42, no. 5 (July 2005): 1021–25. http://dx.doi.org/10.1002/jhet.5570420544.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Kumar, Dheeraj, Gregory H. Imler, Damon A. Parrish, and Jean'ne M. Shreeve. "A Highly Stable and Insensitive Fused Triazolo-Triazine Explosive (TTX)." Chemistry - A European Journal 23, no. 8 (December 21, 2016): 1743–47. http://dx.doi.org/10.1002/chem.201604919.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Epishina, Margarita A., Alexander S. Kulikov, and Leonid L. Fershtat. "Revisiting the Synthesis of Functionally Substituted 1,4-Dihydrobenzo[e][1,2,4]triazines." Molecules 27, no. 8 (April 15, 2022): 2575. http://dx.doi.org/10.3390/molecules27082575.

Full text

Abstract:

A series of novel 1,4-dihydrobenzo[1,2,4][e]triazines bearing an acetyl or ester moiety as a functional group at the C(3) atom of the 1,2,4-triazine ring were synthesized. The synthetic protocol is based on an oxidative cyclization of functionally substituted amidrazones in the presence of DBU and Pd/C. It was found that the developed approach is suitable for the preparation of 1,4-dihydrobenzo[e][1,2,4]triazines, but the corresponding Blatter radicals were isolated only in few cases. In addition, a previously unknown dihydrobenzo[e][1,2,4]triazolo[3,4-c][1,2,4]triazine tricyclic open-shell derivative was prepared. Studies of thermal behavior of the synthesized 1,4-dihydrobenzo[1,2,4][e]triazines revealed their high thermal stability (up to 240–250 °C), which enables their application potential as components of functional organic materials.

APA, Harvard, Vancouver, ISO, and other styles

18

Bianchi, Mario, Alina Butti, and Jacques Perronnet. "A new heterocyclic structure. The [1,2,3]triazolo[1,5-d][1,2,4]triazine." Journal of Heterocyclic Chemistry 25, no. 3 (May 1988): 743–50. http://dx.doi.org/10.1002/jhet.5570250309.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Fahim, Asmaa, Ahmad Farag, Mohamed Shaaban, and Eman Ragab. "Microwave Assisted Synthesis of Pyrazolo[1,5-a]pyrimidine, Triazolo[1,5-a]pyrimidine, Pyrimido[1,2-a]benzimdazole, Triazolo[5,1-c][1,2,4]triazine and Imidazo[2,1-c][1,2,4]triazine." Current Microwave Chemistry 5, no. 2 (January 8, 2019): 111–19. http://dx.doi.org/10.2174/2213335605666180425144009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Akahoshi, Fumihiko, Shinji Takeda, Takehiro Okada, Masahiko Kajii, Hiroko Nishimura, Masanori Sugiura, Yoshihisa Inoue, et al. "Synthesis and Pharmacological Activity of Triazolo[1,5-a]triazine Derivatives Inhibiting Eosinophilia." Journal of Medicinal Chemistry 41, no. 16 (July 1998): 2985–93. http://dx.doi.org/10.1021/jm970759u.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Mironovich, L. M., M. A. Ivanov, and E. P. Koval'chuk. "ChemInform Abstract: Synthesis of 8-tert-Butyl-9-oxo-1,2,4-triazolo[4,5-b]-1,2,4-triazolo [3,4-c]-1,2,4-triazine." ChemInform 33, no. 32 (May 20, 2010): no. http://dx.doi.org/10.1002/chin.200232154.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

El-Shehry, M. F., F. A. A. El-Hag, and E. F. Ewies. "Synthesis and Antimicrobial Study of New Fused Thiazolo[3,2-b]triazine, Triazolo[4,3-b]triazine, and 1,2,4-Triazinone Derivatives." Russian Journal of Organic Chemistry 56, no. 1 (January 2020): 129–36. http://dx.doi.org/10.1134/s1070428020010200.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Fedotov, S. O., and A. S. Hotsulia. "Synthesis and properties of 3-(ethylthio)-9-methyl-6-(alkylthio)pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines." Current issues in pharmacy and medicine: science and practice 15, no. 3 (November 15, 2022): 227–34. http://dx.doi.org/10.14739/2409-2932.2022.3.263994.

Full text

Abstract:

The combination of pyrazole and 1,2,4-triazole fragments in one structure makes it possible to achieve some success in creating potential biologically active compounds. Various factors contribute to this process. Among them, we can note the significant possibilities of chemical transformation involving these cycles, the simplicity, and reliability of methods, the creation of molecules with a certain level of bioavailability and the ability to influence a number of biochemical processes. Taking into account the presented facts, the creation of new compounds in a number of pyrazolo-triazole condensed systems is scientifically attractive with endowed features of practical significance and relevance. The aim of the work was to identify optimal conditions for the production of 3-(ethylthio)-9-methyl-6-(alkylthio)pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines and to study the properties of the target reaction products. Materials and methods. The chemical part of the work involved the step-by-step creation of target reaction products in the form of 3-(ethylthio)-9-methyl-6-(alkylthio)pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines. The first stage was aimed at conducting the interaction of diethyloxalate with acetone with the participation of sodium methylate in a methanol medium. Ethyl-2,4-dioxopentanoate was used in the conversion process to 3-methylpyrazole-5-carbohydrazide with the participation of hydrazine hydrate. Further modification of the molecule consisted of the gradual formation of the structure of 4-amino-5-(3-methylpyrazol-5-yl)-1,2,4-triazole-3-thiol. The next step involved the synthesis of 3-ethylthio-5-(3-methylpyrazol-5-yl)-1,2,4-triazole-4-amine. Further conversion included the production of potassium 3-ethylthio-9-methylpyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazine-6-thiolate and its S-alkyl derivatives along the triazine fragment. Cyclooxygenase-2, lanosterol-14α-demethylase and receptor tyrosine kinase were selected as model enzymes for docking, the crystal structure of which was loaded from the Protein Data Bank. Results. The synthesis of 3-(ethylthio)-9-methyl-6-(alkylthio)-pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines were carried out and the optimal conditions for the production of these substances were determined. The structure of the chemical transformation products was proved and the results of the study of the main physical properties were recorded. The results of virtual studies provided an opportunity to substantiate the prospects of the selected chemical transformation vector, which ultimately made it possible to determine the biological potential of the obtained compounds. Conclusions. Based on the results of the study, information was obtained that gives a certain idea of the possible level of influence of synthesized compounds on the activity of lanosterol-14α-demethylase, which makes it advisable to further search for substances with fungistatic and fungicidal effects.

APA, Harvard, Vancouver, ISO, and other styles

24

Ezema, B. E., L. E. S. Akpanisi, C. G. Ezema, and A. E. Onoabedje. "A New Method of Dimroth Rearrangement in Fused Triazolo[1,5-d]-1,2,4-triazine." Journal of Heterocyclic Chemistry 52, no. 5 (July 31, 2014): 1411–14. http://dx.doi.org/10.1002/jhet.2252.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Kurella, M. G., L. G. Vorontsova, A. R. Amamchyan, and V. A. Dorokhov. "Crystal and molecular structure of 7-phenyl-1,2,4-triazolo[1,5-a]-1,3,5-triazine." Bulletin of the Russian Academy of Sciences Division of Chemical Science 41, no. 6 (June 1992): 1084–86. http://dx.doi.org/10.1007/bf00866591.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Khalil, Mohamed A., Samia M. Sayed, and Mohamed A. Raslan. "Synthesis of New Pyrazolo[5,1-c]triazine, Triazolo[5,1-c]triazine, Triazino[4,3-b]indazole and Benzimidazo[2,1-c]triazine Derivatives Incorporating Chromen-2-one Moiety." Journal of the Korean Chemical Society 57, no. 5 (October 20, 2013): 612–17. http://dx.doi.org/10.5012/jkcs.2013.57.5.612.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Deeb, Ali, Medhat El-Mobayed, Abdel Naby Essawy, Adel Abd El-Hamid, and Atef Mohamid Abd El-Hamid. "Heterocyclic synthesis from 3-amino-4-cyanopyrazole." Collection of Czechoslovak Chemical Communications 55, no. 3 (1990): 728–33. http://dx.doi.org/10.1135/cccc19900728.

Full text

Abstract:

3-Amino-4-cyanopyrazole I reacts with hydroxylamine and with hydrazine to yield 1H,6H-3-aminopyrazolo[3,4-c]pyrazole (III and IV). Diazotized IV couples with 2-naphthol to give the arylazo derivative VI which cyclizes to 9H-naphthol[2,1-e]pyrazolo[3',4':3,4]pyrazolo[5,1-c]-[1,2,4]triazine VII by means of acetic acid. The pyrazol-5-ylthiourea obtained from I and phenyl isothiocyanate undergoes base-catalyzed cyclization to give pyrazolo[3,4-d]pyrimidinethione derivative IX. Compound I reacts with cyclohexane in the presence of zinc chloride to give the tetrahydropyrazolo[3,4-b]quinoline derivative XI. The reaction of I with pyridine 1-oxide affords 4H,5H-pyrazolo[5',1':2,3] [1,2,4]triazolo[1,5-a]pyridine-3-carbonitrile XII.

APA, Harvard, Vancouver, ISO, and other styles

28

Krutošíková, Alžbeta, Slavomír Mastik, Miloslava Dandárová, and Antonín Lyčka. "Synthesis and Reactions of 8-Hydrazinofuro[2',3':4,5]pyrrolo-[1,2-d][1,2,4]triazines." Collection of Czechoslovak Chemical Communications 62, no. 10 (1997): 1612–22. http://dx.doi.org/10.1135/cccc19971612.

Full text

Abstract:

5-Ethyl-8-hydrazinofuro[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine (4a) and its 2-methyl derivative 4b were prepared from 4H-furo[3,2-b]pyrrole-5-carbohydrazides 1a and 1b, respectively. Compounds 1a and 1b reacted with triethyl orthopropionate to give 2a and 2b which afforded with phosphorus(V) sulfide corresponding thiones 3a and 3b. The title compounds 4a and 4b were made by treatment of 3a and 3b with hydrazine hydrate. By reactions of triethyl orthoesters with the title compounds and similar derivatives furo[2'3':4,5]pyrrolo[1,2-d][1,2,4]triazolo[3,4-f][1,2,4]triazines 5a-5j were prepared. Reactions of compounds 4 with some aldehydes and isocyanates led to hydrazones 6a-6c and semicarbazones 7a and 7b, respectively.

APA, Harvard, Vancouver, ISO, and other styles

29

Gomha, Sobhi, and Hatem Abdel-Aziz. "Synthesis of new functionalized derivatives of indolo[2,3-e][1,2,4]-triazolo-[4,5-b]-1,2,4-triazine." Journal of the Serbian Chemical Society 78, no. 8 (2013): 1119–25. http://dx.doi.org/10.2298/jsc120914013g.

Full text

Abstract:

New functionalized 1,2,4-triazolo-[4,3-b]-1,2,4-triazino-[5,6-b]indole derivatives were synthesized via reaction of the hydrazonoyl halides with 5H-2,3-dihydro-1,2,4-triazino[5,6-b]indole-3-thione or its 3-methylthio derivative. The mechanism and the regioselectivity of the studied reactions have been discussed.

APA, Harvard, Vancouver, ISO, and other styles

30

NAITO, Y., and ET AL ET AL. "ChemInform Abstract: Synthesis and Pharmacological Activity of Triazolo[1,5-a]triazine Derivatives Inhibiting Eosinophilia." ChemInform 29, no. 48 (June 18, 2010): no. http://dx.doi.org/10.1002/chin.199848167.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Zhang, Guojie, Wei Hu, Jinchao Ma, Hongwei Yang, and Guangbin Cheng. "Combining 5,6-fused triazolo-triazine with pyrazole: A novel energetic framework for heat-resistant explosive." Chemical Engineering Journal 426 (December 2021): 131297. http://dx.doi.org/10.1016/j.cej.2021.131297.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Qu, Yanyang. "Synthesis and Properties for Benzotriazole Nitrogen Oxides (BTzO) and Tris[1,2,4]triazolo[1,3,5]triazine Derivatives." International Journal of Materials Science and Applications 7, no. 2 (2018): 49. http://dx.doi.org/10.11648/j.ijmsa.20180702.13.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Bera, Hriday, Anton V. Dolzhenko, Lingyi Sun, Sayan Dutta Gupta, and Wai-Keung Chui. "Synthesis andin vitroEvaluation of 1,2,4-Triazolo[1,5-a][1,3,5]triazine Derivatives as Thymidine Phosphorylase Inhibitors." Chemical Biology & Drug Design 82, no. 3 (August 22, 2013): 351–60. http://dx.doi.org/10.1111/cbdd.12171.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Abdelrehim, El-sayed M., and Doaa S. El-Sayed. "A New Synthesis of Poly Heterocyclic Compounds Containing [1,2,4]triazolo and [1,2,3,4]tetrazolo Moieties and their DFT Study as Expected Anti-cancer Reagents." Current Organic Synthesis 17, no. 3 (June 9, 2020): 211–23. http://dx.doi.org/10.2174/1570179417666200226092516.

Full text

Abstract:

Background: 2-amino-3-cyanopyridines are good starting reagents that have been used in synthesis of many heterocyclic compounds such as pyridopyrimidines, [1,2,4]triazolo and [1,2,3,4] tetrazolo derivatives which have biological activities as anti-microbial and cytotoxic activities. Meanwhile [1,2,4]triazolo and [1,2,3,4]tetrazolo derivatives are well known to possess many physiological activities, such as anticancer , antifungal, muscle relaxant, hypnotic, anti-inflammatory, diuretic and antihypertensive activities. A broad class of heterocyclic compounds has been studied to demonstrate their biological activity on the structures of DNA and RNA. Several of important functions make Tankyrases acts as targets in potential drug. Objective: The article focuses on synthesis of [1,2,4]triazolo and [1,2,3,4]tetrazolo derivatives and their theoretical calculations that suggest they are anti-cancer substances. Materials and Methods: DFT and computational studies were performed on the structural properties of experimental molecules experimentally, and significant theoretical calculations were performed based on density functional theory (DFT) with Becke’s three-parameter exchange function21-22 of correlation functional Lee Yang Parr (B3LYP) with the basis set 6-31G (d,p) using Gaussian 03 software23. Geometrical parameters of the optimized structures were calculated and also the charge on each atom (Mulliken charge). Chemcraft program24 was used to visualize the optimized structure and ChemBio3D ultra 12.0 was used to visualize the highest occupied and lowest unoccupied molecular orbitals. Results: Preliminary screening in five studied ligands acts as inhibitors for different active sites along the target. The molecular docking study also revealed that the compound 6c was the most effective compounds in inhibiting Tankyrase I enzyme (2rf5), this result can help strongly in inhibition of carcinogenic cells and cancer treatment. Conclusion: We have described a new practical cyclocondensation synthesis for a series of [1,2,4]triazolo[4,3- c]pyrido[3,2-e] pyrimidine and pyrido[2',3':4,5] pyrimido[6,1-c][1,2,4] triazine from 2-amino-3-cyano-4.6- diarylpyridines. Also polyheterocyclic compounds containing [1,2,4]triazolo and [1,2,3,4]tetrazolo moieties were also synthesized through the reactions of 3-hydrazino-8,10-diaryl [1,2,4]triazolo[4,3-c]pyrido[3,2- e]pyrimidine with both formic acid and the formation of diazonuim salt respectively. Newly synthesized heterocycles structures were confirmed using elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectral data. DFT and computational studies were carried out on five of the synthesized poly heterocyclic compounds to show their structural and geometrical parameters involved in the study. Molecular docking using Tankyrase I enzyme as a target showed how the studied heterocyclic compounds act as a ligand interacting most of active sites on Tankyrase I with a type of interactions specified for H-bonding and VDW. We investigated that the five studied ligands act as inhibitors for different active sites along the target. The molecular docking study also revealed that the compound 6c was the most effective compounds in inhibiting Tankyrase I enzyme (2rf5), this result can help strongly in inhibition of carcinogenic cells and cancer treatment.

APA, Harvard, Vancouver, ISO, and other styles

35

Zohdi, Hussein F. "Reactions with 3-Amino-5-trifluoromethyl[1,2,4]-triazole: A Convenient Route to Fluorinated Triazolo[1,5-c]thiadiazine, Triazolo[1,5-a]triazine, Thiazoles and Thiadiazoles." Journal of Chemical Research, no. 9 (1998): 536–37. http://dx.doi.org/10.1039/a802034e.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

El-Sayed, Wael A., Ibrahim F. Nassar, and Adel A. H. Abdel-Rahman. "Synthesis and antitumor activity of new 1,2,4-triazine and [1,2,4]triazolo[4,3-b][1,2,4]triazine derivatives and their thioglycoside and acyclic C-nucleoside analogs." Journal of Heterocyclic Chemistry 48, no. 1 (September 10, 2010): 135–43. http://dx.doi.org/10.1002/jhet.522.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Hajri, A., and L. Marzouki. "Easy Strategy for the Synthesis of New 5,6-Dihydro-[1,2,4]triazolo[4,3-a][1,3,5]triazine Derivatives." Russian Journal of Organic Chemistry 55, no. 9 (September 2019): 1394–98. http://dx.doi.org/10.1134/s1070428019090203.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

HAJRI, A., and L. MARZOUKI. "EASY STRATEGY FOR THE SYNTHESIS OF NEW 5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A][1,3,5]TRIAZINE DERIVATIVES." Журнал органической химии 55, no. 9 (September 2019): 1475. http://dx.doi.org/10.1134/s0514749219090222.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Vu, Chi B., Bo Peng, Gnanasambandam Kumaravel, Glenn Smits, Xiaowei Jin, Deepali Phadke, Thomas Engber, et al. "Piperazine Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2aReceptor Antagonists." Journal of Medicinal Chemistry 47, no. 17 (August 2004): 4291–99. http://dx.doi.org/10.1021/jm0498405.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

F. Zohdi, Hussein. "Reactions with 3-Amino-5-trifluoromethyl-1,2,4-triazole: a Simple Route to Fluorinated Poly-substituted Triazolo[1,5-a]pyrimidine and Triazolo[5,1-c]triazine Derivatives." Journal of Chemical Research, no. 11 (1997): 392. http://dx.doi.org/10.1039/a701093a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

M. Farag, Ahmad, Mohamed R. Shaaban, and Tamer S. Saleh. "An Efficient Single Step Synthesis of Pyridazine, Pyrazolo[5,1-c]-1,2,4-triazine, 1,2,4-Triazolo[5,1-c]-1,2,4-triazine and 1,2,4-Triazino[4,3-a]benzimidazole Derivatives." HETEROCYCLES 78, no. 3 (2009): 699. http://dx.doi.org/10.3987/com-08-11559.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Abdel-Aziz, Hatem A., Nehal A. Hamdy, Issa M. I. Fakhr, and Ahmad M. Farag. "Synthesis of some novel pyrazolo[1,5-a]pyrimidine, 1,2,4-triazolo[1,5-a]pyrimidine, pyrido[2,3-d]pyrimidine, pyrazolo[5,1-c]-1,2,4-triazine and 1,2,4-triazolo[5,1-c]-1,2,4-triazine derivatives incorporating a thiazolo[3,2-a]benzimidazole moiety." Journal of Heterocyclic Chemistry 45, no. 4 (July 2008): 1033–37. http://dx.doi.org/10.1002/jhet.5570450413.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Kruglenko, V. P., V. P. Gnidets, and M. V. Povstyanoi. "Synthesis of 2-methyl-1,2,4-triazolo[4,3-d]-1,2,4-triazino[2,3-a]-benzimidazole and 2-methyl-9-phenylimidazo[1,2-b]-1,2,4-triazolo[4,3-d]-1,2,4-triazine." Chemistry of Heterocyclic Compounds 36, no. 1 (January 2000): 103–4. http://dx.doi.org/10.1007/bf02256854.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Zohdi, Hussein F. "ChemInform Abstract: Reactions with 3-Amino-5-trifluoromethyl[1,2,4]triazole: A Convenient Route to Fluorinated Triazolo[1,5-c]thiadiazine, Triazolo[1,5-a]triazine, Thiazoles, and Thiadiazoles." ChemInform 30, no. 12 (June 17, 2010): no. http://dx.doi.org/10.1002/chin.199912144.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Li Huixue, 李会学, 胥亨霞 Xu Hengxia, 李志峰 Li Zhifeng, 王晓峰 Wang Xiaofeng, 董小宁 Dong Xiaoning, 袁昆 Yuan Kun, 朱元成 Zhu Yuancheng, and 萧泰 Xiao Tai. "Crystal Structure and Photoelectric Properties of 3-Phenyl-6-(4-Methylphenyl)-1,2,4-Triazolo[4,3-b]-1,2,4-Triazine." Acta Optica Sinica 29, no. 1 (2009): 236–43. http://dx.doi.org/10.3788/aos20092901.0236.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

MIYAMOTO, Yoshiko, Hitoshi KOHNO, Wolfgang PFLEIDERER, Peter BÖGER, and Ko WAKABAYASHI. "Synthesis of 1, 2, 4-Triazolo[1, 5-a]-1, 3, 5-triazine Derivatives for Phytotoxic Activity." Journal of Pesticide Science 20, no. 2 (1995): 119–28. http://dx.doi.org/10.1584/jpestics.20.119.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

El-Mahdy, Kamelia M. "Facile synthesis of novel carbothioylbis[1,2,4]triazolo [4,3-a]pyrimidine and carbothioylbispyrimido[2,1-c] [1,2,4]triazine derivatives." Journal of Sulfur Chemistry 34, no. 5 (February 12, 2013): 539–45. http://dx.doi.org/10.1080/17415993.2013.765431.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Vu, Chi B., Deborah Pan, Bo Peng, Gnanasambandam Kumaravel, Glenn Smits, Xiaowei Jin, Deepali Phadke, et al. "Novel Diamino Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2aReceptor Antagonists." Journal of Medicinal Chemistry 48, no. 6 (March 2005): 2009–18. http://dx.doi.org/10.1021/jm0498396.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Montazeri, Nasser, Majid M. Heravi, Farzaneh Tajfirooz, and Niousha Nazari. "Synthesis of bis[1,2,4]triazolo[4,3-b:1′,5′-d][1,2,4]triazine, a novel polynitrogenated heterocyclic system." Monatshefte für Chemie - Chemical Monthly 148, no. 4 (August 17, 2016): 691–94. http://dx.doi.org/10.1007/s00706-016-1810-y.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

MIRONOVICH, L. M. "ChemInform Abstract: Synthesis of 3-Hydrazino-6-tert-butyl-1,2,4-triazolo(3,4-c)-1,2,4- triazine-5-one." ChemInform 26, no. 25 (August 17, 2010): no. http://dx.doi.org/10.1002/chin.199525170.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!