Relevant bibliographies by topics / Triazol

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Academic literature on the topic 'Triazol'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2022

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Journal articles on the topic "Triazol"

1

Vashchenko, Oleksandr, Dmytro Khomenko, Roman Doroschuk, Ilona Raspertova, and Rostyslav Lampeka. "Synthesis of 3-(2-Hydroxyphenyl)-5-(2-Pyridinyl)-1,2,4-triazoles as a potential chelate ligand for Uranyl ion." French-Ukrainian Journal of Chemistry 8, no. 2 (2020): 1–6. http://dx.doi.org/10.17721/fujcv8i2p1-6.

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Two new uranyl complexes with the molecular formula [(UO2)(H2L1)](СH3OH) and [(UO2)(H3L2)](СH3OH) {H4L1 = 2-[5-[[5-[[5-(2-pyridyl)-1H-1,2,4-triazol-3‑yl]methyl]-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]phenol and H5L2 = 2-[5-[[5-[[5-[[5-(2-pyridyl)-1H-1,2,4‑triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]phenol)} have been synthesized. All compounds have been characterized by NMR and IR spectroscopy. With H4L1 and H5L2 uranyl ion forms mononuclear complexes. In [(UO2)(H3L2)](СH3OH) pyridyl nitrogen was uncoordinated and bonding of H5L2 was realized only through phenol oxygen and N4-nitrogens of triazole cycles.
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2

Nahlé, A., R. Salim, F. El Hajjaji, M. R. Aouad, M. Messali, E. Ech-chihbi, B. Hammouti, and M. Taleb. "Novel triazole derivatives as ecological corrosion inhibitors for mild steel in 1.0 M HCl: experimental & theoretical approach." RSC Advances 11, no. 7 (2021): 4147–62. http://dx.doi.org/10.1039/d0ra09679b.

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The present paper illustrates the investigation of two novel ecological triazole derivative corrosion inhibitors, namely ethyl 2-(4-phenyl-1H-1,2,3-triazol-1-yl) acetate [Tria-CO2Et], and 2-(4-phenyl-1H-1,2,3-triazol-1-yl) acetohydrazide [Tria-CONHNH2].
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Safonov, A. A. "Synthesis, physico-chemical properties of derivatives 3-(alkylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-4-amine." Farmatsevtychnyi zhurnal, no. 3-4 (August 14, 2018): 50–54. http://dx.doi.org/10.32352/0367-3057.3-4.16.03.

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Recently, the search for new compounds with high biological activity, which can be the basis for potential drugs, becomes topical for world scientists. A heterocyclic compound cause particular interest in this area as highly pharmacologically active compounds. Scientists extends interest due to the low toxicity and high reactivity 1,2,4-triazole of the system. It is proved that the combination of triazole nucleus with other heterocyclic systems, especially in the fifth position, causes increased biological effect, and, sometimes, the appearance of new pharmacological activities. The aim of the work was the synthesis of 3-(alkylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-4-amines and their derivatives, study of their physico-chemical properties. A series of new derivatives of the compounds 4-amino-5-R-1,2,4-triazole-3-thione (3-(alkylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-4-amines and N-R-idene)-3-(nonylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-4-amines) was synthesizes. The structure of compounds is set with modern physico-chemical methods of analysis (elemental analysis, 1H-NMR spectroscopy). Individuality is proved by HPLC-MS.
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Panchal, Ashvin D., and Pravin M. Patel. "Synthesis ofN-(5-(Substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine from 4-Amino-4H-1,2,4-triazole." E-Journal of Chemistry 8, no. 3 (2011): 1180–85. http://dx.doi.org/10.1155/2011/658708.

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N-(4H-1,2,4-Triazol-4-yl)acetamide (2) were prepared by reaction of 4-amino-4H-1,2,4-triazole (1) with acetyl chloride in dry benzene. It has been reacted with various aromatic aldehyde to afford 3-(substitutedphenyl)-N-(4H-1,2,4-triazol-4-yl)acrylamide (3a-e). The synthesis ofN-(5-substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine (4a-e) is achieved by the cyclisation of3a-ewith hydrazine hydrate in ethanol. The structures of synthesized compounds were characterized by1H NMR and IR spectroscopic studies. The purity of the compounds was checked by thin layer chromatography.
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Adamchyk, S. V., and A. L. Michal’chuk. "Potential aromatase inhibitors and antiestrogen agents based on stilbene and stilbazole derivatives." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 56, no. 1 (March 19, 2020): 81–87. http://dx.doi.org/10.29235/1561-8331-2020-56-1-81-87.

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Abstract. Widely used forms of endocrine therapy for women with hormone-dependent breast cancer include blocking the biosynthesis of estrogens through using inhibitors of cytochrome P450 19A1 (aromatase). A series of new stilbene and stilbazole based aromatase inhibitors on are prepared. Z-isomers of 4-(2-(pyridin-4-yl)-1-(1H-1,2,4-triazol-1-yl)vinyl) benzonitrile, 4-(2-(pyridin-3-yl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile, 4-(2-(4-fluorophenyl)-1-(1H-1,2,4-triazol1-yl)vinyl)benzonitrile, 4-(2-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile, 4-(2-(4-bromophenyl)-1-(1H-1,2,4triazol-1-yl)vinyl)benzonitrile, 4-(2-(3,4-dimethoxyphenyl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile were prepared by condensation of 4-((1H-1,2,4-triazol-1-yl)methyl)benzonitrile and corresponding aldehyde in presence of strong base followed by dehydration of obtained alcohols. Isomerization to corresponded E-isomers was carried out in the presence of UV light.
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Srinivasa Reddy, T., Hitesh Kulhari, V. Ganga Reddy, A. V. Subba Rao, Vipul Bansal, Ahmed Kamal, and Ravi Shukla. "Synthesis and biological evaluation of pyrazolo–triazole hybrids as cytotoxic and apoptosis inducing agents." Organic & Biomolecular Chemistry 13, no. 40 (2015): 10136–49. http://dx.doi.org/10.1039/c5ob00842e.

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A series of pyrazolo–triazole hybrids were designed and synthesized by combining the 1,3-diphenyl pyrazole and triazole scaffolds to obtain (1-benzyl-1H-1,2,3-triazol-4-yl)(1,3-diphenyl-1H-pyrazol-4-yl)methanones.
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Bai, Shi-Qiang, Lu Jiang, David James Young, and T. S. Andy Hor. "Hybrid 1,2,3-Triazole Supported CuII Complexes: Tuning Assembly and Weak Interaction-Driven Crystal Growth." Australian Journal of Chemistry 69, no. 4 (2016): 372. http://dx.doi.org/10.1071/ch15650.

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Two new dinuclear CuII complexes [Cu2Cl4(L1)2] (1) and [Cu2Cl4(L2)2] (2) (L1 = 2-((4-(2-(cyclopentylthio)ethyl)-1H-1,2,3-triazol-1-yl)methyl)pyridine; L2 = 2-((4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)methyl)benzonitrile) were synthesised and characterised by single-crystal X-ray diffraction (XRD), powder XRD, thermogravimetric analysis, elemental analysis and IR measurements. The picolyl-triazole ligand L1 coordinates in a chelate-bridging mode forming a dinuclear structure 1. The more rigid pyridyl-triazole ligand L2 chelates only, generating a chloride-bridged dinuclear complex 2. Both crystals of complexes 1 and 2 show dominant plate shapes that correlate with weak 2D H-bonding interactions in the lattice. A mononuclear structure (3, [CuCl2(L3)2]⋅6H2O, L3 = 3-((4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)methyl)benzonitrile) yields block shape crystals that correlate with 3D H-bonding interactions. This study demonstrates tunable assembly at the molecular level and the relationship of crystal shape with weak lattice interactions.
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Karpun, Yevhen, and Nataliia Polishchuk. "Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol." ScienceRise: Pharmaceutical Science, no. 3(31) (June 30, 2021): 64–69. http://dx.doi.org/10.15587/2519-4852.2021.235976.

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The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was to obtain new S-substituted derivatives of 1,2,4-triazole-3-thiols, study physicochemical parameters of the substances synthesized, evaluate the antimicrobial activity of new S-derivatives of the 4-R1-5-((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol series, and study some regularities of the “structure – biological activity” relationship for the synthesized compounds as well. Materials and methods. The subject of the study was new S-substituted 1,2,4-triazoles containing 2-oxopropan-1-yl and 2-aryl-2-oxoethan-1-yl substituents. The antimicrobial activity was studied by double serial dilutions on test cultures of Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), and Candida albicans (ATCC 885-653). The results of the biological screening showed that at a concentration of 125 g/mL, all synthesized substances showed activity (MIC – in the range of 31.25 - 62.5 μg/mL, MBCK - in the range of 62.5–125 μg/mL) against strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans. Variation of substituents on the sulfur atom did not lead to a significant change in antimicrobial and antifungal activities among derivatives of 4-R1-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl) thio)methyl)-4H-1,2,4-triazole-3-thiols. Conclusions. Biological screening data indicate the prospects for the search for new antimicrobial substances among the abovementioned derivatives of 1,2,4-triazoles. The most active compounds were 1-((4-ethyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazol-3-yl)thio)propan-2-one and 1-(4-methoxyphenyl)-2-(4-ethyl-5-(((3-(pyridin-4-yl)-1H)-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazol-3-yl)thio)ethanone, which showed the most pronounced antimicrobial activity against the Pseudomonas aeruginosa strain (MIC – 31.25 μg/mL, MBcK - 62.5 μg/mL)
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Childs, Bradley J., Donald C. Craig, Marcia L. Scudder, and Harold A. Goodwin. "Coordination of the Strong Field Terimine System 6-Triazol-3-yl-2,2′-bipyridine and Substituted Derivatives. Electronic and Structural Properties of Bis(ligand)iron(II) Complexes." Australian Journal of Chemistry 51, no. 10 (1998): 895. http://dx.doi.org/10.1071/c97202.

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A terminal pyridine ring in terpyridine has been replaced by a triazole or substituted triazole moiety to give the tridentates 6-(1,2,4-triazol-3-yl)-2,2´-bipyridine, 6-(1-methyl-1,2,4-triazol-3-yl)-2,2´-bipyridine, 6-(5-methyl-1,2,4-triazol-3-yl)-2,2´-bipyridine and 6-(1,5-dimethyl-1,2,4-triazol-3-yl)-2,2´-bipyridine. The effects of coordination of these on the electronic and structural properties of the [FeN6]2+ species are considered. The primary effect is a reduction in the ligand field but salts of the [FeN6]2+ derivatives are essentially low spin (singlet ground state) at room temperature. A small and temperature-dependent population of quintet state species is indicated by Mössbauer spectra but in no instance is a complete singlet → quintet transition observed up to 383 K. The electronic spectra of the [FeN6]2+ species are similar to that of [Fe(trpy)2]2+ but the energy of the charge-transfer transition is higher, indicating less effective metal ion → donor π-interaction than in the terpyridine complex. Consistent with this, the Mössbauer isomer-shift values are greater than for [Fe(trpy)2]2+ and the E½ values for the [FeN6]3+ /[FeN6]2+ couples are less positive than for [Fe(trpy)2]2+. Structural data reveal average Fe–N distances normal for low-spin iron(II) but with greater distortion of the coordination environment than in [Fe(trpy)2]2+. When present, the >NH group of the triazole moiety is hydrogen-bonded to solvate water and the anion in the hydrated tetrafluoroborate salts. Bis(6-(1,2,4-triazol-3-yl)-2,2´-bipyridine)iron(II) tetrafluoroborate tetrahydrate: monoclinic, space group P21/c, a 15·917(7), b 18·432(5), c 10·845(5) Å, β 94·36(2)°, Z 4; bis(6-(1-methyl-1,2,4-triazol-3-yl)-2,2´-bipyridine)iron(II) tetrafluoroborate: triclinic, space group P−1, a 11·68(1), b 11·96(2), c 12·46(2) Å, α 82·93(8), β 72·30(9), γ 68·49(10)°, Z 2; bis(6-(5-methyl-1,2,4-triazol-3-yl)-2,2´-bipyridine)iron(II) tetrafluoroborate monohydrate: monoclinic, space group P21/c, a 10·715(4), b 25·818(5), c 11·039(4) Å, β 90·08(2)°, Z 4; bis(6-(1,5-dimethyl-1,2,4-triazol-3-yl)-2,2´-bipyridine)iron(II) triflate tetrahydrate: orthorhombic, space group P bcn; a 20·654(6), b 11·618(3), c 16·080(6) Å, Z 4.
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Nami, Navabeh, Mehdi Forozani, Vida Khosravimoghadam, and Rahmatallah Taherinasab. "Synthesis and Characterization of Mono- and Bicycle Heterocyclic Derivatives Containing 1, 2,4-Triazole, 1,3,4-Thiadiazine and 1,3-Thiazole Rings." E-Journal of Chemistry 9, no. 1 (2012): 161–66. http://dx.doi.org/10.1155/2012/867637.

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Reaction of tartaric acid with thiocarbohydrazide(2)and thiosemicarbazide(6)afforded 1,2-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-ethane-1,2-diol(3)and 1,2-bis(5-mercapto-4H-1,2,4-triazol-3-yl)-ethane-1,2-diol(7). Reaction of compounds3and7with DMAD (dimethylacety lendi carboxylate) and DEAD (diethylacetylendicarboxylate) gave 1,2-bis(7-[(z)-methoxycarbonylmethylen]-5,6-dihydro-5H-6-one-[1,2,4] riazolo[3,4-b] [1,3,4] thiadiazin-3-yl)-ethan-1,2-diol(4), 1,2-bis(7-[(z)-ethoxycarbonylmethylen] -5,6-dihydro -5H-6-one-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-ethan-1,2- diol(5)and 1,2-bis(6-[(z)-methoxycarbonylmethylen]-5-oxo-[1,3]thiazolo[2,3-c] [1,2,4]triazol-3-yl)-ethan-1,2-diol(8)in good yields.
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Dissertations / Theses on the topic "Triazol"

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Fiscus, David Michael. "The chemistry of 3-diazo-3H̲-1,4-triazole and 3H̲-1,2,4- triazol-3-ylidene /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487260135358319.

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Canduzini, Hugo Antonio. "Síntese e funcionalização de 1,2,3-triazóis via reação de cicloadição [3+2] de azidas e acetilenos terminais." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-07032013-094439/.

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O objetivo deste trabalho é explorar a síntese e funcionalização de 1,2,3- triazóis empregando o uso de reações do tipo \"Click-chemistry\", que é uma abordagem para a síntese de diversos compostos com base em reações de formação de ligação carbono-heteroátomo, onde a reação é estereoespecífica, altamente eficiente e geralmente com elevados rendimentos e em alguns casos ausência de subprodutos. O composto 1,2,3-triazol, sendo o material de partida para a continuidade do projeto foi preparado a partir do álcool propargílico (4) em presença de uma azida orgânica (1) e utilizando cobre(I) como agente promotor. Após a obtenção de uma série de compostos 1,2,3-triazólicos (2), procedeu-se a etapa de tosilação da hidroxila e posterior cicloadição multicomponente de um novo 1,2,3-triazol formando compostos bis-triazólicos. Os bis-triazóis (5) obtidos foram testados frente a cepas fúngicas, responsáveis por dermatites, com resultados satisfatórios. Ainda essas estruturas poderão ser empregados como blocos construtores para a síntese de estruturas mais complexas.
The aim of this work has been exploring the synthesis and functionalization of 1,2,3-triazoles employing the use of \"click-chemistry\" concept, which is defined as an approach for synthesis of various compounds based on reactions of carbon-heteroatom bond formation, which the reaction is stereospecific, high-efficiently, commonly gives high yields and in some cases no by-products are formed. The compound 1,2,3-triazole, which is the main starting material for the next steps was prepared from propargyl alcohol (4) in the presence of an organic azide (1) and copper(I) as a reaction promoter. Subsequently with a series of 1,2,3-triazole (2n) prepared we proceeded to the next step which is the substitution of hydroxyl for a tosyl group and after that a multicomponent cycloaddition of a new 1,2,3-triazole compound forming bis-triazoles. Bis-triazoles (5) were tested against fungal strains, responsible for dermatitis, with delighted results, furhtermore this class of strutures can be used as building blocks to improve efficiency in some other more complex structure.
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Wagner, Daniel [Verfasser], and Peter [Akademischer Betreuer] Strohriegl. "Neue Triazol- und Triazin-basierte Matrixmaterialien für blaue organische Leuchtdioden / Daniel Wagner. Betreuer: Peter Strohriegl." Bayreuth : Universität Bayreuth, 2014. http://d-nb.info/1064499899/34.

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Bortolotto, Guilherme Pivotto. "Síntese de 1,2,4-triazol-5-ilamino pirimidinas trifluormetil substituídas." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/10456.

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This work describes the synthesis and characterization of fourteen 4-trifluoromethyl-2-[3-(pyridyl)-1H-1,2,4-triazol-5-ylamino]pyrimidines (6, 7), from the cyclocondensation reaction of N-[3-(pyridyl)-1H-1,2,4-triazol-5-yl]guanidines (4, 5), a 1,3-dinucleophile precursor of the type (N-C-N), with 1,1,1-trifluoro-4-alkoxy-3-alken-2-ones (1), a versatile 1,3-dieletrophile. The 1,1,1-trifluoro-4-alkoxy-3-alken-2-ones (1), of the general formula F3C-C(O)- CH=C(R)-OR1 where R1 = Me, Et and R = H, Me, Ph, 4-FPh, 4-MePh, 4-OMePh, Furyl, were obtained from trifluoroacetylation reactions of enolethers or acetals derived of acyclic ketones. The reactions of 1,1,1-trifluoro-4-alkoxy-3-alken-2-ones (1) with N-[3-(pyridyl)-1H-1,2,4-triazol-5-yl]guanidines (4, 5) was carried in ethanol in reflux for 18 hours, leading to end products in 40-68% yield. The compounds were characterized by 1H and 13C NMR experiments, and the purity these compounds proved by elemental analysis.
Este trabalho descreve a síntese e caracterização de uma série de catorze 4-trifluormetil-2-[3-(piridil)-1H-1,2,4-triazol-5-ilamino]pirimidinas (6, 7), a partir de reações de ciclocondensação de N-[3-(piridil)-1H-1,2,4-triazol-5-il]guanidinas (4, 5), precursores 1,3-dinucleofílicos do tipo (N-C-N), com 1,1,1-triflúor-4-alcóxi-3-alquen-2-onas (1), versáteis precursores 1,3-dieletrofílicos. As 1,1,1-triflúor-4-alcóxi-3-alquen-2-onas (1), de fórmula geral F3C-C(O)-CH=C(R)- OR1 onde R1 = Me, Et e R = H, Me, Ph, 4-FPh, 4-MePh, 4-OMePh, Furil, foram obtidas a partir de reações de trifluoracetilação de enoléteres ou de acetais derivados de cetonas acíclicas. As reações de 1,1,1-triflúor-4-alcóxi-3-alquen-2-onas (1) com N-[3-(piridil)-1H-1,2,4-triazol-5-il]guanidinas (4, 5) foram realizadas em etanol sob refluxo por 18 horas, levando aos produtos finais com rendimentos de 40-68%. Os compostos sintetizados foram caracterizados por experimentos de RMN de 1H e 13C, e sua pureza comprovada por Análise Elementar.
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González, Mojica Norberto. "Estudio de la Oxidación de 1,2,3-triazoles en presencia de un sistema H2O2-CF3CO2H." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/71110.

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El estudio de la reactividad de N-óxidos de heterociclos aromáticos es un tema de interés creciente hoy en día. La investigación se ha enfocado en la formación de enlaces C-X por medio de metales de transición en N-óxidos de 1,2,3-triazoles tipo 1,2, tal y como lo demostró Keith Fagnou y colaboradores con en el N-óxido de piridina.1-4 Esta área de la química puede desempeñar un papel importante en la formación eficiente de nuevos derivados de 1,2,3-triazoles, que se sabe, tienen un rol importante en muchas áreas de la ciencia. La química de N-óxidos tipo 1,3 de 1,2,3-triazoles no ha sido explorada, pero, como se demuestra, resulta ser una química relevante al tener una reactividad hacia los C4 y C5 sin la racionalización de estructuras resonantes, muy semejante a las sales de triazolonio para la formación de carbenos atípicos. En los estudios reportados, los 1,2,3-triazoles empleados son sintetizados por algún método de ciclación oxidativa.5,6 Esta tesis describe la obtención de N-óxidos tipo 1,3 de 1,2,3-triazoles provenientes de la cicloadicón alquino-azida catalizada por Cu (I) en un sistema H2O2-CF3CO2H. Se describe la ventaja de usar el TFPAA en comparación de otros peroxiácidos empleados. La aplicación de esta metodología se limita a 1,2,3-triazoles cuyos grupos funcionales no sean sensibles a medios ácidos fuertes; tal fue el caso del estudio de la N-oxidación de 1,2,3-triazoles derivados de éteres propargílicos. Se hizo un estudio comparativo de las propiedades químicas y físicas de los N-óxidos y los 1,2,3-triazoles con los resultados obtenidos de Resonancia Magnética Nuclear de 1H, 13C, Espectroscopía de Infrarrojo y Espectrometría de masas. Los resultados obtenidos de nueve nuevos ejemplos de N-óxidos de 1,2,3-triazoles, que no se han informado en la literatura, reflejan las ventajas de utilizar la cicloadición alquino-azida catalizada por cobre (I); ésta resulta ser una nueva metodología, sencilla y práctica para síntesis de estos compuestos, lo cual es un buen comienzo para determinar su reactividad hacia reacciones como la O-acilación y reacciones de acoplamiento cruzado.
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6

Lima, Milena Moreira. "Síntese de peptídeo modificado contendo grupo 1,2,3-triazol 1,4-dissubstituído." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-05092013-135757/.

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Peptídeos são biomoléculas que apresentam extensa variedade estrutural e funcional, atuando em diversos processos biológicos relevantes. Estas moléculas são amplamente utilizadas na terapêutica, constituindo, atualmente, um campo investigativo bastante promissor para o desenvolvimento de novos fármacos, especialmente no desenvolvimento de vacinas sintéticas. Os avanços científicos relacionados às técnicas de identificação, análise e purificação tem estimulado diversas pesquisas na busca por fármacos baseados em peptídeos, os quais podem ser obtidos a partir de fontes naturais ou por métodos químicos (em solução ou em fase sólida), enzimático ou combinação de ambos (semi-síntese) e via tecnologia do DNA recombinante. Entretanto, devido às limitações próprias dos peptídeos naturais, tais como, suscetibilidade proteolítica, toxicidade e baixa biodisponibilidade, torna-se necessária a síntese de peptídeos modificados. Como a função biológica de um peptídeo é definida por sua conformação estrutural, a inserção de modificação em uma estrutura peptídica deve ser capaz de manter ou estabilizar esta conformação estrutural. O desenvolvimento de novas e eficientes rotas de síntese de peptídeos modificados torna-se necessário para superar as limitações relacionadas à suscetibilidade proteolítica, toxicidade e baixa biodisponibilidade, afim de contribuir para novas estratégias terapêuticas, em especial no desenvolvimento de vacinas. Desta forma, a inserção de grupo 1,2,3-triazol tem fornecido propriedades físicoquímicas desejáveis no desenvolvimento de fármacos. O objetivo deste trabalho foi desenvolver um método de síntese de peptídeos contendo grupo 1,2,3-triazol 1,4- dissubstituído, como o peptídeo 1, o qual é constituído por dezesseis resíduos de treonina e um grupo 1,2,3-triazol 1-4-dissubstituído entre os resíduos Thr8 e Thr9 (NH2-(Thr)7-Thr-(ciclo 1,2,3-triazol 1,4-dissubstituído)-Thr-(Thr)7-OH). Adicionalmente, devido à semelhança com mucinas de T. cruzi, as quais apresentam rica composição em resíduos de treonina, 1 poderá ser empregado na preparação de peptideomiméticos destas mucinas e no desenvolvimento de vacinas relacionadas à processos infecciosos causados por T. cruzi. A preparação de 1 envolveu uma associação entre síntese de peptídeo em fase sólida e reações de ciclo-adição azido-alcino 1,3 dipolar catalisada por cobre (I) (CuAAC). Inicialmente, o método utilizado foi padronizado a partir da síntese do modelo dipeptídeo de treonina (8), cuja ligação peptídica foi substituída pelo grupo 1,2,3-triazol 1,4- dissubstituído (NHFmoc-Thr-(ciclo 1,2,3-triazol 1,4 dissubstituído)-Thr-OH). A estratégia via CuAAC conduziu à obtenção do dipeptídeo modificado em excelente rendimento (98%) e permitiu estabelecer as condições a serem empregadas na obtenção do peptídeo mais complexo de cadeia longa 1. A reação de CuAAC gerou o peptídeo 1 com rendimento bruto satisfatório (70%). A obtenção de 1 foi confirmada pela análise de Ressonância Magnética Nuclear de próton (RMN 1H), a qual permitiu identificar a presença do grupo 1,2,3-triazol 1,4-dissubstituído. Adicionalmente, análises posteriores por espectrometria de massas (ESI-MS) sugerem a obtenção do peptídeo 1.
Peptides are biomolecules which present great structural and functional variety, acting in several biological processes. These molecules are widely used in therapeutics, and recently represent a very promising field for development of novel drugs, specially on synthetic vaccines. Scientific advances related to identification techniques, analysis and purification stimulate researches in attempt to produce peptides-based drugs, which can be extracted from natural sources or chemically synthesized (in liquid or solid phase), enzymatic process or both (semi-synthesis) and recombinant DNA technology. However, due to limitations concerning natural peptides, such as, proteolytic liability, toxicity and low bioavailability, becomes necessary the synthesis of modified peptides. Being biological function of a peptide defined by its structural conformation, adding a modification in a peptide structure must be able to maintain or stabilize it. The development of novel and efficient synthetic route of modified peptides is necessary to overcome the limitations related to proteolytic liability, toxicity and low bioavailability, to contribute with novel therapeutic strategies, mostly development of vaccines. So, adding a 1,2,3-triazole group can afford desirable chemical-physical properties in drug discovery. The objective was develop a method to synthesize peptides containing 1,4-disubstituted 1,2,3-triazole group, such as peptide 1, which is constituted by sixteen threonine residues and one 1,4 disubstituted 1,2,3-triazole group (NH2-(Thr)7-Thr-(1,4- disubstituted 1,2,3-triazole cycle)-Thr-(Thr)7-OH). Moreover, due to the similarity with T. cruzi mucins that present great composition of threonine, 1 can be employed in development of vaccines related to infectious processes caused by T. cruzi. The preparation of 1 envolved an association between the solid-phase synthesis of peptide and reactions of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Initially, the method was standardized from synthesis of threonine dipeptide (8), whose peptide bond was replaced by 1,4-disubstituted 1,2,3-triazole group (NHFmoc-Thr-(1,4-disubstituted 1,2,3-triazole cycle)-Thr-OH). The strategy via CuAAC gave the modified dipeptide in good yield (98%) and allowed to establish the conditions to prepare the more complex peptide with long chain 1. The CuAAC reaction gave the peptide 1 with good yield (70%). Compound 1 was confirmed by NMR proton analysis which showed the presence of 1,4-disubstituted 1,2,3-triazole group. Additionally, further analysis of mass spectrometry (ESI-MS) suggest the achievement of peptide 1.
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Moura, Paula Caroline Silva. "Efeitos fisiológicos da aplicação de triazol e estrobilurina em soja." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/11/11144/tde-19042013-102707/.

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Com o aumento da população mundial, torna-se necessário a busca de tecnologias para o incremento da produção de alimentos. O cultivo da soja (Glycine max (L.) Merrill) destaca-se entre as atividades econômicas mundiais que apresentam crescimentos expressivos nas últimas décadas e apesar da crescente expansão territorial e produção agrícola, tem a produtividade influenciada por fatores externos e internos durante o cultivo, sendo o principal deles, a incidência de doenças. Atualmente, a doença mais preocupante é a ferrugem da soja, causada pelo fungo Phakopsora pachyrhizi Sydow & Sydow. Para o controle desta doença devastadora, recomenda-se a aplicação concomitante de fungicidas triazóis e estrobilurinas, que, conforme alguns dados da literatura, além de atuarem de forma protetora e curativa, apresentam efeitos na produtividade. O objetivo do trabalho foi esclarecer o efeito fisiológico do triazol ciproconazol e da estrobilurina azoxistrobina em plantas de soja sem incidência de ferrugem. O trabalho foi realizado em casa de vegetação no Departamento de Ciências Biológicas da ESALQ/ USP, em Piracicaba, SP no período entre dezembro de 2008 a maio de 2009 com plantas de soja cultivar Pintado. As condições hídricas e do solo foram mantidas conforme as recomendações para a cultura. Os tratamentos foram constituídos pelos fungicidas Ciproconazol (triazol), Azoxistrobina (estrobilurina) e Óleo mineral (Nimbus) e as aplicações realizadas nos estádios R1, R4 (duas aplicações) e R1, R4 R5,4 (três aplicações). Foram analisados aspectos de produção (Número, massa fresca, seca e média das vagens, massa seca de grãos e peso de 100 grãos) e aspectos anatômicos (espessura do limbo foliar, espessura e largura da nervura central, espessura do xilema e do floema), sendo que nestas análises, foram utilizados apenas os tratamentos em que foram realizados três aplicações do fungicida. O delineamento experimental foi em blocos inteiramente ao acaso, com 9 tratamentos e 5 blocos. Os resultados apontam redução no número de vagens por planta, massa fresca e seca das vagens, número de grãos e massa seca de grãos tratados com a mistura entre o triazol e a estrobilurina. Sob o aspecto anatômico, houve incremento na espessura do limbo foliar, espessura e largura da nervura central e a espessura do sistema vascular (xilema e floema). Com base nos dados obtidos no trabalho, conclui-se que, nas condições em que foi realizado, a aplicação do triazol e da estrobilurina em plantas de soja restringe o potencial de produção de grãos no cultivar Pintado.
With increasing world population, it is necessary to search for technologies to increase food production. The cultivation of soybean (Glycine max (L.) Merrill) stands out among the economic activities that present significant growth worldwide in recent decades, and despite the increasing territorial expansion and agricultural production, productivity is influenced by external and internal factors during cultivation , the main one being, the incidence of diseases. Currently, the disease more worrying soybean is rust caused by Phakopsora pachyrhizi Sydow & Sydow. To control this devastating disease, we recommend the application of triazole and strobilurin fungicides, which, according to some literature data, act so protective and curative, and have effects on productivity. The objective of this study was to clarify the physiological effect of the triazole cyproconazole and strobilurin azoxystrobin in soybean without rust incidence. The study was conducted in a greenhouse at the Department of Biological Sciences ESALQ / USP, Piracicaba, SP, Brazil in the period between December 2008 and May 2009 with soybean cultivar Pintado. The soil and water conditions were maintained as recommended for the crop. The treatments consisted of fungicides cyproconazole (triazole), azoxystrobin (strobilurin) and mineral oil (Nimbus) under applications at the stages R1, R4 (two applications) and R1, R4, R5, 4 (three applications). We analyzed aspects of production (number, fresh, dry and average pod dry grain and 100-grain weight) and anatomical aspects (leaf thickness, width and thickness of the midrib, thickness of xylem and phloem), and in these analyzis, we used only the treatments that were performed three applications of fungicide. The experimental design was a randomized block design with 9 treatments and 5 blocks. The results showed a reduction in the number of pods per plant, fresh and dry weight of pods, number of grains and dry grain treated with the mixture of triazole and strobilurin. Under the anatomical aspect, there was an increase in leaf thickness, width and thickness of the midrib and the thickness of the vascular system (xylem and phloem). By the data obtained in the study, it was concluded that, under the conditions in which it was performed, the application of triazole and strobilurin in soybean plants restricts the potential for grain production in the cultivar Pintado.
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Schmollinger, Daniel [Verfasser], and Thomas [Akademischer Betreuer] Ziegler. "Synthese 1,2,3-triazol-verknüpfter Kohlenhydrat-Übergangsmetallkomplexe / Daniel Schmollinger ; Betreuer: Thomas Ziegler." Tübingen : Universitätsbibliothek Tübingen, 2014. http://d-nb.info/1196877408/34.

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Hölzel, Torsten [Verfasser]. "Triazol- und Imidazolylidene - von elektronenarmen Carbenen zu lumineszenten Komplexen / Torsten Hölzel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/120115930X/34.

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Meudtner, Robert M. "Neuartige Triazol-basierte aromatische Rückgrate für die Makromolekulare und Supramolekulare Chemie." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16057.

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Ein Ansatz der Darstellung von neuartigen funktionalen Materialien basiert auf der Synthese von Foldameren mit charakteristischen Eigenschaften, die eine Kontrolle über Formgebung und Gestaltung der Makromoleküle und derer Aggregate zulassen. Bislang sind gerade größere Foldamerstrukturen definierter Größe und Form meist schwer darstellbar und eine strukturelle Modifizierbarkeit nicht ohne weiteres möglich. In dieser Arbeit konnte gezeigt werden, dass die hohe Effizienz der seit 2002 bekannten Kupfer(I)-katalysierten 1,3-dipolaren Azid-Alkin-Cycloaddition, kurz “Klick“-Reaktion genannt, verwendet werden kann, um neuartige heteroaromatische Gerüste für die Konstruktion von diversen (makromolekularen) Strukturen zu generieren. Hierbei wird der bei der Reaktion entstehende Triazol-Ring gezielt als funktionale und strukturgebende Einheit genutzt. Zunächst wurden auf einfache und hochmodulare Weise 2,6-Bis(1-aryl-1,2,3-triazol-4-yl)pyridine (BTPs) dargestellt, die in einer hufeisenförmigen, planaren Konformation vorliegen und sich daher als helikogene Einheiten für die Konstruktion von helikalen aromatischen Foldameren eignen. Zudem stellen die BTP-Strukturen eine neue Klasse von pyridinzentrierten, tridentaten Liganden dar. Sie koordinieren an eine Vielzahl von Übergangsmetallionen unter Ausbildung von Metallkomplexen, die über interessante magnetische und lumineszierende Eigenschaften verfügen. Durch die Koordination, aber auch bei Protonierung, lassen sich die BTP-Gerüste von der gebeugten anti-anti-Konformation in eine gestreckte syn-syn-Konformation schalten. Dies wurde in Lösung, im kristallinen Festkörper und an der Flüssig-Fest-Grenzfläche zu Graphit untersucht. Über Selbstorganisation großflächig ausgebildete hochgeordnete BTP-Monoschichten an der Graphitoberfläche lassen sich mit Hilfe der Rastertunnel-Mikroskopie visualisieren und durch oben genannte externe Stimuli umstrukturieren. Eine neue Klasse von (BTP-basierten) responsiven heteroaromatischen oligomeren und polymeren Foldameren wurde mit Hilfe der „Klick“-Reaktion generiert. Die Oligomeren, sogenannte ”Klickamere“, mit einer Länge von 17 aromatischen Ringen zeigen in polaren Lösungsmitteln ein ausgeprägtes helikales Faltungsverhalten. Ein aus 17 aromatischen Ringen bestehender Foldamerstrang ist gegenüber Chloridionen responsiv, wobei es durch die Wechselwirkung mit diesem achiralen Stimulus bemerkenswerter Weise zu einer Helixinversion kommt. Die entsprechenden responsiven Polymere falten in eine stabile helikale Konformation, die bei Zugabe von Metallionen aufbricht und zu der Bildung von koordinativ kreuzverlinkten, stark viskosen Gelen führt.
One approach to develop novel functional materials is based on the synthesis of macromolecules with characteristic properties, in particular foldamers. However, preparation and structural variation of macromolecules of controllable size and specific shape are often cumbersome and versatile synthetic routes are still needed. In this dissertation, the high efficiency of the so called “click”-reaction, i.e. the Cu(I)-catalyzed Huisgen-type 1,3-dipolar cycloaddition, has been used to design a novel class of heteroaromatic (macromolecular) scaffolds. In these structures the formed triazole moieties constitute an essential integral part rather than a mere connecting unit. In a first step, structurally varying 2,6-Bis(1-aryl-1,2,3-triazolyl-4-yl)pyridines (BTPs) have been generated in an easy and modular way. The BTP scaffold adopts a kinked conformation and therefore functions as helicogenic building block for the construction of helical foldamers. Additionally, the BTP framework is responsive towards protonation and transition metal ion complexation, thereby undergoing a significant structural change from the kinked anti-anti into the extended syn-syn conformation. The conformational switching has been investigated in solution and in the solid state but can also be visualized at the liquid-solid interface on graphite by STM imaging. The BTPs represent a novel class of pyridine-centered, tridentate ligands, which form complexes with interesting magnetic and luminescent properties by the coordination to numerous transition metal ions. Varying heteroaromatic oligomeric and polymeric foldamers with remarkable properties have been generated using the “click”-reaction as synthesis tool. The BTP building blocks, which have (partly) been integrated into the backbones, support the stability of the helical conformation and provide responsiveness towards external stimuli. Three oligomer series of different length have been synthesized and analyzed. Oligomers consisting of 17 aromatic rings, termed clickamers, fold into a helical conformation in polar solvents. One of the three clickamers shows an unexpected phenomenon of helix inversion upon interaction with chloride ions as an achiral stimulus. The corresponding polymeric strands fold into an even more stable helical conformation, which breaks up upon exposure to transition metal ions leading to coordinatively crosslinked, highly viscous gels.
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Books on the topic "Triazol"

1

Trianon. Bratislava: Ministerstvo kultúry SR, 1995.

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Moscato, Enzo. Trianon. Napoli: A. Guida, 1999.

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Trianon. Napoli: A. Guida, 1999.

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Deák, Ladislav. Trianon. Bratislava: Ministerstvo kultúry Slovenskej republiky, 1995.

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Aira, César. Triano. [Place of publication not identified]: Milena Caserola, 2014.

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László, Bitó. Trianon trilógia. [Budapest]: Aura, 1994.

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Trianon-legendák. Budapest: Jaffa, 2010.

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Košmrlj, Janez, ed. Click Triazoles. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-29429-7.

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Száraz, Miklós György. Fájó Trianon. Budapest: Mérték, 2011.

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Trial by trial. Eugene, Or: Harvest House Publishers, 1985.

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Book chapters on the topic "Triazol"

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) perchlorate complex with 1,2,4-triazol (hydrated)." In Magnetic Properties of Paramagnetic Compounds, 43–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_20.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) perchlorate complex with 1,2,4-triazol (anhydrous, smaple1)." In Magnetic Properties of Paramagnetic Compounds, 45–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_21.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) perchlorate complex with 1,2,4-triazol (anhydrous, sample2)." In Magnetic Properties of Paramagnetic Compounds, 47–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_22.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) complex with 2-(triazol-3-yl)-1,10-phenanthroline." In Magnetic Properties of Paramagnetic Compounds, 78–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_38.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) complex with 2-(triazol-3-yl)-1,10-phenanthroline." In Magnetic Properties of Paramagnetic Compounds, 80–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_39.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) complex with 2-(triazol-3-yl)-1,10-phenanthroline." In Magnetic Properties of Paramagnetic Compounds, 82–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_40.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) complex with 2-(triazol-3-yl)-1,10-phenanthroline." In Magnetic Properties of Paramagnetic Compounds, 84–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_41.

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Railliet, Antoine P., Anil D. Naik, Aurelian Rotaru, Jacqueline Marchand-Brynaert, and Yann Garcia. "1D iron(II) spin crossover complexes with 1,2,4-triazol-4-yl-propanoic acid." In ICAME 2011, 199–203. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-4762-3_31.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) perchlorate complex with 2,6-bis(1,2,4-triazol-3-yl)pyridine." In Magnetic Properties of Paramagnetic Compounds, 22–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_6.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) tetrafluoroborate complex with 2,6-bis(1,2,4-triazol-3-yl)pyridine." In Magnetic Properties of Paramagnetic Compounds, 24. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54231-6_7.

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Conference papers on the topic "Triazol"

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Gnoatto, Eduarda Socovoski, Vitoria Karolini Betim Fieldkircher Caus, Cristian Ferreira Corona, Letiére Cabreira Soares, and Dalila Moter Benvegnú. "EFEITO ANTIMICROBIANO DE COMPOSTOS TRIAZÓLICOS EM CEPAS DE Staphylococcus aureus ISOLADAS DE CASOS DE MASTITE EM BOVINOS." In I Congresso Nacional de Microbiologia Clínica On-Line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1198.

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Introdução: A mastite bovina é a principal enfermidade da indústria leiteira mundial, a qual desencadeia um processo inflamatório na glândula mamária de bovinos. Esta doença é causada principalmente por bactérias, que predominam devido às más condições higiênico-sanitárias no ambiente e péssimas condições de saúde dos animais. O uso indiscriminado de antibióticos em rebanhos leiteiros tem gerado aumento da resistência bacteriana, dificultando o tratamento dessa doença, o que por sua vez acaba prejudicando o bem-estar do animal e a qualidade do leite produzido. E, dentre as diversas bactérias pode ser citado o Staphylococcus aureus, que se destaca devido á sua resistência. À vista disso, pesquisas têm buscado alternativas para tratamento desta doença, os quais não acarretem mais resistência bacteriana. Um exemplo disto é a utilização de compostos triazólicos e seus derivados, que se destacam na área de química medicinal e podem ser usados para a síntese de vários compostos heterocíclicos com diferentes atividades biológicas como: antiviral, antibacteriana, antifúngica e antituberculose. Objetivo: Realizar uma revisão da literatura sobre ação antimicrobiana de compostos triazólicos sobre S. aureus. Métodos: Foi realizada uma revisão bibliográfica no banco de dados Scholar Google no qual foram selecionados trabalhos entre os anos de 2008 e 2020 com um nº de 16, cujos termos utilizados foram: "triazol", "antimicrobial" e "S. aureus". Resultado: Os métodos mais utilizados para avaliação da atividade antimicrobiana foram Difusão em poço e Concentração Inibitória Mínima. Os compostos derivados de triazol, em todos os estudos apresentaram efeito antimicrobiano significativo em relação às cepas de S. aureus. Alguns trabalhos relataram que geralmente a presença de qualquer substituinte no anel benzeno presente no composto levou ao aumento da atividade antimicrobiana frente a todas as cepas bacterianas testadas. Além disso, foi demonstrado que a presença de átomos ou grupos que retiram ou doam elétrons nas posições orto ou para em relação à fenila ligada ao triazol é capaz de aumentar a atividade antibacteriana desses compostos. Conclusão: Por meio da revisão bibliográfica deste estudo, observou-se que os compostos derivados de triazol têm sido relatados por apresentarem notável efeito antimicrobiano em cepas de S. aureus.
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Seijas, Julio A., M. Pilar Vázquez-Tato, Alberto Diaz-Seivane, and María García-Fernández. "Microwave Assisted Synthesis of Tripodal Tris(1H-1,2,3-triazol-4-yl) Cyanurates and Melamines." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-c013.

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Jesus da Silva Júnior, Heber, and Alcino Palermo de Aguiar. "SÍNTESE E CARACTERIZAÇÃO DE SAL ENERGÉTICO DERIVADO DA 3-NITRO-1,2,4-TRIAZOL-5-ONA." In 10º Encontro Técnico de Materiais e Química. Rio de Janeiro, Rio de Janeiro: Even3, 2020. http://dx.doi.org/10.29327/etmq10.238310.

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do Nascimento Martinez, Leandro, Marcinete Latorre Almeida, QUELLI LARISSA OLIVEIRA SANTANA, SABRINA BAPTISTA FERREIRA, and Carolina Bioni Garcia Teles. "CARACTERIZAÇÃO DA CINÉTICA DE MORTE E DO ESTÁGIO ESPECÍFICO DO COMPOSTO BI-TRIAZOL 7RJ." In Semana Nacional de Ciência e Tecnologia - IFRO-Campus Cacoal. ,: Even3, 2021. http://dx.doi.org/10.29327/snctcacoal2020.282254.

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Kovalovs, Armands, Māris Turks, and Ērika Bizdēna. "Synthesis and reactions of 2,6-bis-(4-substituted-1,2,3-triazol-1-yl)-9-(β-D-arabinofuranosyl)purines." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112304.

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Cosyn, Liesbet, Kenneth A. Jacobson, and Serge Van Calenbergh. "2-(1,2,3-Triazol-1-yl) N6-CH3-substituted adenosine derivatives: Highly potent and selective A3 receptor ligands." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507393.

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Jansa, Petr, Petr Špaček, Antonín Holý, Ivan Votruba, and Zlatko Janeba. "Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112467.

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Seijas, Julio, M. Pilar Vázquez-Tato, Xesús Feás, and Marta Carracedo-Taboada. "Click reactions in the synthesis of tripodal 1H-1,2,3-triazol derivatives of 1,3,5-triazinane-2,4,6-trione." In The 15th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00689.

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Keung Chui, Wai, Anton Dolzhenko, and Hriday Bera. "Synthesis of N-(3(5)-Aryl-1,2,4-triazol-5(3)-yl)-N'-carbethoxythioureas and Their Tautomerism in DMSO Solution." In The 13th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00187.

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Tokareva, M. A., K. L. Obydennov, P. A. Slepukhin, O. A. Vysokova, and T. V. Glukhareva. "Reaction of sodium 4-acetyl-1-phenyl-1H-1,2,3-triazol-5-olate with 1,2,3-thiadiazole-4-carboxylic acid hydrazide." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087392.

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Reports on the topic "Triazol"

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Haley, Mark V., Roman G. Kuperman, and Ronald T. Checkai. Aquatic Toxicity of 3-Nitro-1,2,4-Triazol-5-One. Fort Belvoir, VA: Defense Technical Information Center, September 2009. http://dx.doi.org/10.21236/ada508035.

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Adams, Valerie H. In Vitro Endocrine Disruption Screening of 3-nitro-1,2,4-triazol-5-one (NTO). Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ad1007533.

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Becher, Julie, Samuel Beal, Susan Taylor, Katerina Dontsova, and Dean Wilcox. Photo-transformation of aqueous nitroguanidine and 3-nitro-1,2,4-triazol-5-one : emerging munitions compounds. Engineer Research and Development Center (U.S.), August 2021. http://dx.doi.org/10.21079/11681/41743.

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Two major components of insensitive munition formulations, nitroguanidine (NQ) and 3-nitro-1,2,4-triazol-5-one (NTO), are highly water soluble and therefore likely to photo-transform while in solution in the environment. The ecotoxicities of NQ and NTO solutions are known to increase with UV exposure, but a detailed accounting of aqueous degradation rates, products, and pathways under different exposure wavelengths is currently lacking. We irradiated aqueous solutions of NQ and NTO over a 32-h period at three ultraviolet wavelengths and analyzed their degradation rates and transformation products. NQ was completely degraded by 30 min at 254 nm and by 4 h at 300 nm, but it was only 10% degraded after 32 h at 350 nm. Mass recoveries of NQ and its transformation products were >80% for all three wavelengths. NTO degradation was greatest at 300 nm with 3% remaining after 32 h, followed by 254 nm (7% remaining) and 350 nm (20% remaining). Mass recoveries of NTO and its transformation products were high for the first 8 h but decreased to 22–48% by 32 h. Environmental half-lives of NQ and NTO in pure water were estimated as 4 and 6 days, respectively. We propose photo-degradation pathways for NQ and NTO supported by observed and quantified degradation products and changes in solution pH.
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Crouse, Lee C., and Arthur J. O'Neill. Acute Inhalation Toxicity and Blood Absorption of 3-Nitro-1,2,4-Triazol-5-One (NTO) in Rats. Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada590390.

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Beal, Samuel, Susan Taylor, Rebecca Crouch, and Anthony Bednar. Environmental analysis of aqueous 3-nitro-1,2,4-triazol-5-one (NTO) by ion chromatography with conductivity detection. Engineer Research and Development Center (U.S.), July 2020. http://dx.doi.org/10.21079/11681/37415.

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Crouse, Lee C., and Emily M. Lent. Repeated-Dose and Reproductive/Developmental Toxicity of NTO (3-Nitro-1,2,4-Triazol-5-One) in the Rat. Fort Belvoir, VA: Defense Technical Information Center, March 2014. http://dx.doi.org/10.21236/ada597490.

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Lent, Emily M., Lee C. Crouse, and Allison M. Jackovitz. Extended One-Generation Reproductive Toxicity Test in Rats Exposed to 3-Nitro-1,2,4 Triazol-5-One (NTO), October 2013-March 2014. Fort Belvoir, VA: Defense Technical Information Center, April 2016. http://dx.doi.org/10.21236/ad1007621.

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Song, Jian. Test for Chemical Induction of Chromosome Aberrations in Cultured Chinese Hamster Ovary (CHO) Cells with and without Metabolic Activation, Test Article: 3-Nitro-1,2,4-Triazol-5-one (NTO). Fort Belvoir, VA: Defense Technical Information Center, October 2008. http://dx.doi.org/10.21236/ada518834.

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Shukla, Manoj K., Luidmyla K. Sviatenko, Sergly I. Okovytyy, Danuta Leszczynska, and Jerzy Leszczynski. Catalytic Role of Solvated Electron in the Spontaneous Degradation of Insensitive Munition Compounds : Computational Chemistry Investigation. Engineer Research and Development Center (U.S.), July 2021. http://dx.doi.org/10.21079/11681/41122.

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The DNAN (2,4-dinitroanisole), NTO (3-nitro-1,2,4-triazol-5-one), and NQ (nitroguanidine) are important insensitive energetic materials used in military applications. They may find their way to the environment during manufacturing, transportation, storage, training, and disposal. A detailed investigation of possible mechanisms for self-degradation of radical-anions formed by addition of solvated electron to DNAN, NTO, and NQ species was performed by computational study using the PCM(Pauling)/M06-2X/6-311++G(d,p) approach. Obtained results suggest that only NQ radical-anion is able for self-degradation by elimination of nitrite anion. Formation of urea radical on the earlier stage of the NQ radical-anion degradation was also predicted.
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Song, Jian. Evaluation of a Test Article in the Salmonella typhimurium/Escherichia coli Plate Incorporation Mutation Assay in the Presence and Absence of Induced Rat Liver S-9. Test Article 3-Nitro-1,2,4-Triazol-5-one (NTO). Fort Belvoir, VA: Defense Technical Information Center, October 2008. http://dx.doi.org/10.21236/ada518833.

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