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Relevant bibliographies by topics / Tri-delivery

Academic literature on the topic 'Tri-delivery'

Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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Journal articles on the topic "Tri-delivery"

1

Zhao, Yinan, Shubiao Zhang, Yuan Zhang, Shaohui Cui, Huiying Chen, Defu Zhi, Yuhong Zhen, Shufen Zhang, and Leaf Huang. "Tri-peptide cationic lipids for gene delivery." Journal of Materials Chemistry B 3, no. 1 (2015): 119–26. http://dx.doi.org/10.1039/c4tb01312c.

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Norris, Debra A., Joy P. Burke, and Anna L. Speer. "Tri-level service delivery: An alternative consultation model." School Psychology Quarterly 5, no. 2 (1990): 89–110. http://dx.doi.org/10.1037/h0090605.

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Mondal, Pravakar, Hemant H. Alur, and Thomas P. Johnston. "Evaluation of TRI-726 as a drug delivery matrix." Drug Development and Industrial Pharmacy 37, no. 8 (March 21, 2011): 995–1001. http://dx.doi.org/10.3109/03639045.2011.555913.

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Rao, Shasha, Yunmei Song, Frank Peddie, and Allan M. Evans. "A novel tri-layered buccal mucoadhesive patch for drug delivery: assessment of nicotine delivery." Journal of Pharmacy and Pharmacology 63, no. 6 (May 3, 2011): 794–99. http://dx.doi.org/10.1111/j.2042-7158.2011.01283.x.

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Zaw Thin, May, Helen Allan, Robin Bofinger, Tomas D. Kostelec, Simon Guillaume, John J. Connell, P. Stephen Patrick, et al. "Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours." Nanoscale 12, no. 31 (2020): 16570–85. http://dx.doi.org/10.1039/d0nr03237a.

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Zhao, Y. N., Y. Z. Piao, C. M. Zhang, Y. M. Jiang, A. Liu, S. H. Cui, D. F. Zhi, Y. H. Zhen, and S. B. Zhang. "Replacement of quaternary ammonium headgroups by tri-ornithine in cationic lipids for the improvement of gene delivery in vitro and in vivo." J. Mater. Chem. B 5, no. 39 (2017): 7963–73. http://dx.doi.org/10.1039/c7tb01915g.

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Gamache, Raymond F., Kirstin A. Zettlitz, Wen-Ting K. Tsai, Jeffrey Collins, Anna M. Wu, and Jennifer M. Murphy. "Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging." Chemical Science 11, no. 7 (2020): 1832–38. http://dx.doi.org/10.1039/c9sc05007h.

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To provide a universal approach towards the targeted delivery of PET and optical imaging agents, we have developed a tri-functional platform (TFP) for the facile construction of modular, target-specific tracers.

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Gajendiran, M., and S. Balasubramanian. "Biodegradable Amphiphilic Tri-Block Copolymeric Nanoparticles for Controlled MTB Drug Delivery." Advanced Materials Research 584 (October 2012): 460–64. http://dx.doi.org/10.4028/www.scientific.net/amr.584.460.

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. A series of biodegradable amphiphilic tri-block copolymers (PLGA–PEG–PLGA) have been derived from the diblock copolymer poly (lactic–co–glycolic acid (PLGA)) and polyethylene glycol (PEG). The mycobacterium tuberculosis (MTB) drug pyrazinamide (PZA) loaded polymer nanoparticles (NPs) have been prepared by probe-sonication followed by w/o/w double emulsification technique. The copolymers have been characterized by FTIR and 1HNMR spectroscopic techniques, TG-DTA analysis, GPC analysis and powder XRD pattern. The MTB drug loaded polymeric NPs have been characterized by FESEM, powder XRD, HRTEM and XPS analysis. The drug loading efficiency, drug content and in vitro drug release studies have been carried out by spectrophotometry. The drug loading efficiency and drug content of triblock copolymeric NPs were higher than these of diblock copolymeric microparticles (MPs). The in vitro drug release studies indicate that the NPs exhibit initial burst release followed by controlled release of PZA for longer durations. The drug release kinetics mechanism has been evaluated by zero order, first order, Korsemeyer-Peppas (KP) and Higuchi models.

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Newby, Gemma E., Erik B. Watkins, Daniel Hermida Merino, Paul A. Staniec, and Oier Bikondoa. "In situ Rheo-GISANS of triblock copolymers: gelation and shear effects on quasi-crystalline structures at interfaces." RSC Advances 5, no. 126 (2015): 104164–71. http://dx.doi.org/10.1039/c5ra20215a.

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The behaviour of polymeric systems at surfaces and under flow is very important in many applications, from drug delivery to lubrication. Here, we have studied the thermotropic phases formed by a model tri-block copolymer using in situ Rheo-GISANS.

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Megawari, Megawari, Djoni Djoni, and Culita Culita. "Analisis dan Perancangan Sistem Pembelian dan Pengolahan TBS pada PT. Tri Bahtera Srikandi." remik 6, no. 1 (November 30, 2021): 70–81. http://dx.doi.org/10.33395/remik.v6i1.11223.

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Perkembangan teknologi informasi yang pesat mendorong pelaku usaha untuk mengadopsinya sebagai bagian dalam aktivitas operasionalnya. Salah satunya adalah dengan menerapkan sistem informasi dalam mendukung operasional bisnis dan menghasilkan informasi untuk mendukung pengambilan keputusan. PT. Tri Bahtera Srikandi merupakan salah satu perusahaan di Tandikek yang bergerak dibidang perkebunan dan industri pengolahan tandan buah segar (TBS) menjadi Crude Palm Oil (CPO) yang memiliki pabrik di Desa Tandikek, Kecamatan Ranto Baek, Kabupaten Mandailing Natal. Saat ini, proses pembelian pada PT. Tri Bahtera Srikandi masih dilakukan secara manual dan belum memiliki sistem yang terkomputerisasi. Aktivitas pembelian mulai dari pembuatan kontrak, pembelian dan penerimaan barang masih menggunakan metode konvensional. Hal ini menimbulkan banyak masalah seperti kesalahan pencatatan, data yang duplikat ataupun tidak valid serta kesulitan mengetahui informasi terkait pembelian, penerimaan dan pembayaran. Oleh karena itu, penelitian ini bertujuan menganalisis dan merancang sistem informasi pembelian dan pengolahan data Tandan Buah Segar (TBS) pada PT. Tri Bahtera Srikandi. Metodologi yang digunakan dalam penelitian ini adalah System Development Life Cycle (SDLC). Sistem informasi ini dirancang dengan menggunakan Microsoft Visual Studio 2012 dan Microsoft SQL 2012. Untuk rancangan proses dan alur data dikembangkan dengan menggunakan Data Flow Diagram (DFD). Dari hasil penelitian diperolah rancangan sistem usulan yang dapat memberikan kemudahan dalam mengetahui delivery order dari supplier, menyesuaikan penomoran delivery order dengan kontrak, pengelolaan pembelian, menyajikan laporan yang dibutuhkan dan mempermudah dalam melihat pembayaran. Diharapkan hasil dari analisis dan perancangan sistem informasi ini dapat dijadikan referensi untuk pengembangan sistem informasi pembelian Tandan Buah Segar (TBS) bagi PT. Tri Bahtera Srikandi.

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Dissertations / Theses on the topic "Tri-delivery"

1

Zheng, Xian-Ling, and 丁先玲. "Risk factors of preterm delivery of tri-service general hospital a case-control study." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/91312089189074654128.

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DING, XIAN-LING, and 丁先玲. "Risk factors of preterm delivery of tri-service general hospital a case-control study." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/13015420107419128591.

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Choonara, Bibi Fatima. "A Tri-Functionalized Oral Core-Melt Tablet (OCMT) for enhanced delivery of gastro-sensitive proteins and synthetic peptides." Thesis, 2017. https://hdl.handle.net/10539/24911.

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A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfillment of the requirements for the degree of Doctor of Philosophy. Department of Pharmacy and Pharmacology, University of the Witwatersrand, South Africa Johannesburg, 2017.
The global pharmaceutical biotechnology industry is continually growing and increased amounts of protein and peptide-based therapeutics are entering into the market. Conventionally, these therapeutic proteins and peptides are administered intravenously, subcutaneously or intramuscularly as oral routes of administration may result in their degradation in the gastrointestinal tract (O’ Connor, 2009). The parenteral route limits patient acceptability and convenience. Oral dosage forms, particularly tablets, are considered one of the most common and widely used routes of drug administration and accounts for approximately 50% of all dosage forms on the market (Oh et al., 2012). Thus, the development of oral technologies for therapeutic proteins and peptides remain a dynamic research field despite its many challenges. Successful oral delivery of proteins and peptides require the accomplishment of three key tasks: protection of the macromolecules from degradation in the gastrointestinal tract (GIT), permeation through the intestinal barrier and the absorption of molecules into the systemic circulation. Currently, no clinically useful oral formulations have been approved but several attempts have been made to overcome the challenges of low oral bioavailability resulting from poor absorption, poor permeation and enzymatic degradation of the proteins and peptides in the GIT. Present strategies attempt to provide structural protection of the proteins and peptides and improved absorption through the use of enzyme inhibitors, absorption enhancers, novel polymeric delivery systems and chemical modification. However, each of these technologies possesses limitations that preclude the successful oral delivery of proteins and peptides. The design and development of the novel Tri-functionalized OCMT attempts to breakthrough this market by triple targeting the major challenges governing successful oral delivery of proteins and peptides. Essentially, the Tri-functionalized OCMT is made up of three distinct functional components; the core-eutectic region, the outer polymer shell and the ‘smart’ polymeric sheet. Triple targeting was achieved by incorporating the bioactive into a core-melt archetype within the tablet and facilitating the process of in situ crosslinking which significantly affects the way the bioactive is protected within the compressed tablet matrix as well providing desirable bioactive release kinetics. In addition, the incorporation of a co-inhibitory ‘smart’ polymeric sheet provided added protection and enabled an improved absorption by virtue of its intrinsic properties and co-inhibition of the major determinants, CYP3A4 and Pgp, of poor absorption and low oral bioavailability. Lastly, targeting of enzymatic degradation was achieved by incorporation of a pH modifier that functions to transiently lower the micro-environmental pH and reduce the optimal environment for enzyme activity. The combination of the distinct formulatory components contained within the Tri-functionalized OCMT was extensively evaluated through in-depth in vitro physicochemical and physicomechanical characterization, ex vivo analyses and in vivo performance. In vitro and ex vivo characterization enabled the optimization of design variables and promoted the achievement of desirable functionalities for the attainment of optimum in vivo performance. In vivo analyses of the Tri-functionalized OCMT in the Large White pig model revealed an enhanced oral bioavailability of the incorporated peptides, octreotide and exenatide, following oral administration, as compared to their conventionally administered subcutaneous counterparts. In addition, pharmacokinetic analysis of the Tri-functionalized OCMT confirmed the maintenance of sustained, therapeutic levels of both octreotide and exenatide over the 24 hour period, supporting a convenient once-daily dosing. The rate at which protein and peptide-based therapeutics are developing is astounding, and this consequently increases the demand and focus towards achieving a simpler and more effective oral delivery of therapeutic proteins and peptides. The Tri-functionalized OCMT has successfully demonstrated its feasibility in enhancing the oral delivery of therapeutic proteins and peptides up to a preclinical stage. It may potentially serve as a viable alternative to the conventional parenteral route of administration for the treatment of various disease conditions by incorporating a multitude of proteins and peptides into its versatile design. The advancement of the Tri-functionalized OCMT to the clinical stage and beyond may ultimately improve patient outcomes and change the face of therapeutic protein and peptide delivery globally.
LG2018

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Yun, Seonho. "Intracellular Microenvironment Triggered Co-delivery of Anticancer Drugs and Genes." Thesis, 2019. http://hdl.handle.net/2440/120605.

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Currently, infallible cancer treatment has not been achieved. Doxorubicin (DOX), an active anticancer drug, initiates the apoptotic signaling pathway by intercalating topoisomerase-II, resulting in DNA replication disorder and producing reactive oxygen species that can damage DNA and activate cell death receptors. However, long-term DOX administration is always accompanied with serious multidrug resistance (MDR) and adverse side-effects. Therefore, delivery systems for DOX and gene drug, such as miRNA-21 inhibitor (miR-21i) which mitigates MDR, have been developed to reduce side-effects caused by non-selective cellular uptake of co-drugs in the absence of suitable delivery systems. However, difficulties in designing delivery systems for different types of drugs to achieve both high therapeutic efficacy and low side-effects have been reported. In this thesis, various biodegradable and biocompatible smart microgels are developed for DOX and gene co-delivery to achieve maximal anticancer performance and minimal side-effects. The microgel delivery carriers are prepared by crosslinking biocompatible low molecular weight polyethyleneimine (PEI800) using glutathione-cleavable diselenide crosslinkers. To the carriers, DOX is conjugated via various intracellular microenvironment sensitive linkers, and genes are electrostatically loaded to glutathione-cleavable polyethyleneimine. Finally, anionic hyaluronic acid (HA) surface coating is able to inhibit serum protein adsorption during blood circulation and promote HA receptor-mediated endocytosis for selective metastatic cancer cells. The hydrodynamic sizes of resulting nano-drugs at 100–200 nm allow prolonged circulation. The developed nano-drugs degrade into less than 10 nm fragments in the glutathione-rich cytosol of cancer cells by cleaving diselenide crosslinkers, allowing intensive gene release and complete urinary excretion. Real-time tracks of release profiles are developed using fluorescence quenching technique. On the other hand, to eliminate premature release, DOX is conjugated to microgel carriers through various linkers for efficiently controlled spatiotemporal release in cancer lysosomes, such as acid-responsive hydrazone linkers, glutathione-cleavable diselenide linkers and enzyme-cleavable peptide linkers. The system comprising of DOX with a hydrazone bond demonstrates 4.4-fold higher in vitro anticancer performance on MDA-MB-231 cell line than free DOX. The nano-drug system of miR-21i and conjugated DOX via hydrazone and diselenide dual bonds completely surpasses DOX premature leakage in physiological condition and results in a high survival rate of over 95 % for HEK293T kidney cell line at a DOX concentration of 2.5 μg mL−1, but it reveals 3.2-fold increase in therapeutic effect on the multidrug-resistant cancer cell line of MDA-MB-231-R12w compared with free DOX. To simplify DOX loading process, diselenide crosslinkers can be used for both microgel synthesis and DOX conjugation to produce a simultaneous release system of gene and DOX in cytosol. The introduction of ATP aptamer to the miR-21i and DOX co-delivery system further increases intracellular DOX accumulation in MDA-MD-231-R12w cells with 4.2-fold higher anticancer performance than free DOX but with low cytotoxicity to healthy cells. To achieve sequential release, the nano-drug system of miR-21i and conjugated DOX with a caspase-3-cleavable DEVDC peptide linker enables the step release of miR-21i followed by DOX. Compared with free DOX, this systems demonstrates a 7.3-fold increase in anticancer effect on MDA-MB-231-R24w and negligible side effects. In summary, we have developed various smart nano-drugs with outstanding advantages of low cytotoxicity, complete biodegradability, targeting and selective delivery and high anticancer performance to MDR cells. Our approach suppresses traditional gene and drug delivery concepts, and advances knowledge for successive design of delivery systems in clinical applications.
Thesis (Ph.D.) -- University of Adelaide, School of Chemical Engineering and Advanced Materials, 2019

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Books on the topic "Tri-delivery"

1

Schneider, Dona. Public health and public health services: The Connecticut-New Jersey-New York, Tri-State Region. New Brunswick, N.J: Center for Urban Policy Research, 1992.

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Book chapters on the topic "Tri-delivery"

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Zhai, Congcong, Junni Zou, and Yunfei Zhang. "Video Content Caching and Delivery for Tri-Party Joint Profit Optimization." In Lecture Notes in Computer Science, 239–51. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-71589-6_22.

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Nasongkla, N., P. Akarajiratun, and S. Hongeng. "Development of Tri-component Copolymer Rods as Implantable Drug Delivery Systems for Liver Cancer Therapy." In IFMBE Proceedings, 317–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03887-7_92.

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Manisekaran, Ravichandran. "Designing a Nanocargo with Fe3O4@Au: A Tri-pronged Mechanism for MR Imaging, Synaphic Drug-Delivery, and Apoptosis Induction in Cancer Cells." In Springer Theses, 91–113. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67609-8_4.

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Conference papers on the topic "Tri-delivery"

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Kwon, Ohyeon, and Jong-Un Won. "Measurement of the Delivery Environment Using Demo Parcel with Tri-axial Accelerometer." In 2019 34th International Technical Conference on Circuits/Systems, Computers and Communications (ITC-CSCC). IEEE, 2019. http://dx.doi.org/10.1109/itc-cscc.2019.8793436.

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Mair, Hugh, Gordon Lin, Achuta Thippana, Kent Li, Manzur Rahman, Wuan Kuo, David Yen, et al. "3.4 A 10nm FinFET 2.8GHz tri-gear deca-core CPU complex with optimized power-delivery network for mobile SoC performance." In 2017 IEEE International Solid-State Circuits Conference (ISSCC). IEEE, 2017. http://dx.doi.org/10.1109/isscc.2017.7870258.

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Kelsey, Matthew, Thomas Fanchin, Steffen Van Der Veen, Espen Dahl, and Kristina Harila Skjold. "Multilateral Technology Enables Record Reservoir Contact in North Sea Subsea Well." In SPE Annual Technical Conference and Exhibition. SPE, 2022. http://dx.doi.org/10.2118/210399-ms.

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Abstract In the 1990's many oil plays in the North Sea were originally deemed uneconomical due to the limited technology available to address the associated challenges. Horizontal and eventually multilateral applications were introduced to address this challenge. For over two decades multilateral technology has extended the production life of these fields by continuing to evolve to meet the demands of increasingly complex subsea applications. Over this history, multilateral applications have evolved from dual-laterals with standalone screens and commingled flow to tri-lateral and quad-lateral intelligent completions as common multilateral completion strategies in the North Sea. A significant number of wells originally completed as a dual-lateral have since been recompleted twice or even three times to produce reserves previously left behind. As investment and availability of new fields decline, operators face challenges to extend the production life of mature fields while also working to reduce overall development cost, cycle times, and carbon footprint. Further challenges include delivery of wells and facility systems using less in-field construction hours at a lower baseline cost. This paper will focus on the evolution of a mature well in a region that has been installing multilateral wells for over two decades. Originally drilled as the world's first tri-lateral well and several years later re- drilled again as a quad-lateral to add further reservoir contact. As production decline and strategic targets esteemed to be more profitable are within reach from the same template, further re-drills as a dual-lateral and then a further quad-lateral has been utilized to add significant reservoir contact for further economic production. It highlights the technology used to keep this well on production for over two decades and the benefits of expanding the use of this technology as fields become slot restricted. It also highlights the benefits this technology delivers in significantly increasing reservoir exposure and the time savings brought by drilling new lateral legs in existing subsea wells. The case study will include discussion of workover operations, completions, isolation methods, and lateral creation systems. Through four separate multilateral installations in one subsea slot, the production life has been extended beyond 20 years. The paper also provides insight as to methodology for continually improving reliability of multilateral installations to maximize efficiencies.

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Krishnakumar, D., and K. S. Jaganathan. "Development of nasal HPV vaccine formulations." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685403.

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Cervical cancer is the second most cancer in women worldwide with over 500000 new cases and 275000 deaths being registered every year. With nearly 73000 women dying every year, India now tops the world in cervical cancer deaths. India represents 26.4% of all women dying of cervical cancer globally. Cervical cancer estimated to be responsible for about 5% of human cancers worldwide. Currently available vaccines may not provide complete protection against all HPV types as the protection is primarily type specific. Furthermore, the available vaccines are delivered via intramuscular route and require three doses and require cold chain supply which increases the cost of vaccine. Therefore a single dose vaccine delivered via non-invasive route (nasal) that protects against multiple HPV types would be a cost effective and better alternative to the currently available HPV vaccines. The main objective of this study was to prepare HPV antigen loaded poly (lactic-co-glycolic acid) (PLGA) and Tri Methyl Chitosan (TMC) coated PLGA microparticles and compare their efficacy as nasal vaccine. The developed formulations were characterized for size, zeta potential, entrapment efficiency, mucin adsorption ability, in vitro and in vivo studies. PLGA microparticles demonstrated negative zeta potential whereas PLGA-TMC microparticles showed higher positive zeta potential. The protein loading efficiency was found as above 80%. Results indicated that PLGA-TMC microparticles demonstrated substantially higher mucin adsorption when compared to PLGA microparticles. HPV antigen encapsulated in PLGA-TMC particles elicited a significantly higher secretory (IgA) immune response compared to that encapsulated in PLGA particles. Present study demonstrates that PLGA-TMC microparticles with specific size range can be a better carrier adjuvant for nasal subunit vaccines. Surface modified PLGA microparticles proved great potential as a nasal delivery system for HPV infections where systemic and mucosal responses are necessary particularly in conditions after viral pathogens invade the host through the mucosal surface.

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Kuyken, Chris Wilhelm, Mohamed Elsaied Elkasrawy, Ali Mubarak Saeed Al Breiki, Yahia Abdelfattah Mahmoud Elgendy, and Ahmed Gamal Abdelaal. "High Performance Drilling Onshore Abu Dhabi." In SPE/IADC Middle East Drilling Technology Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/202142-ms.

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Abstract High performance drilling is an approach applied in the drilling of hole sections that are not primarily benefitting from data acquisition except the minimum like gamma ray and directional. Therefore these sections are drilled with high ROP and subsequently cased in support of reducing well costs. High performance drilling leading to continuous ROP optimization has been proven a key enabler for invisible lost time reduction (ILT), being one of the current regional well delivery challenges. In this paper we explain the approach followed by the team comprising of operator, service provider and equipment provider in reducing the impact of ILT during the actual drilling phase. We learnt that creating a performance culture based on rigorously applying of best practices and the eagerness to continuously improve on past performance as a first strategy and the application of novel directional drilling motor technology as the second resulted in ROP performance records. For example in one field an average ROP record was achieved of 188 ft / hour a 15 % improvement from the previous record. We learnt that in particular the communication between all parties i.e. the client office, the service provider and the team on the rig was the most important factor in order to create a shared vision on the need to improve the ROP based on the last ROP performance benchmark. Secondly the latest motor technology and the way of how it gets deployed, available to the team played a major role, and brought the performance level to a new dimension whereby the ROP was targeted to be optimum instead of maximum thereby reducing the risk for NPT related incidents (hole problems, equipment break-down) and repair and maintenance cost becoming cost prohibitive. This paper is specifically meant to share best practices from the last 10 years with the larger UAE drilling community. It is service provider contribution to provide insights for the new generation drilling engineers and directional drillers in safely pushing the drilling performance to higher levels all the time targeting the ILT in hole making. The work has proved that a combination of low torque high speed and high torque low speed can successfully performance drill all vertical hole sizes in the UAE on-shore fields either using tri-cone or PDC bits.Figure 1High performance motor

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Kelsey, Matthew, Thomas Fanchin, Steffen Van Der Veen, and Marie Houge Nesheim. "Multilateral Re-Entry Technology Compounding Benefits and Extending Production Life Past Two Decades." In Offshore Technology Conference. OTC, 2022. http://dx.doi.org/10.4043/31855-ms.

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Abstract For over two decades multilateral technology has extended the production life of fields in the North Sea by continuing to evolve to meet the demands of increasingly complex deepwater applications. The use of multilateral technology delivers a higher recovery factor supported by the cumulative production of the multiple laterals. Over this history, multilateral applications have evolved from dual-laterals with standalone screens and commingled flow to the subject well of this paper whose slot has been kept active for over two decades through the use of re-entry multilateral systems. The well was originally completed as a dual-lateral and has since been recompleted twice to produce reserves previously left behind. As investment and availability of new fields decline, operators face challenges to extend the production life of mature fields while also working to reduce overall development cost, cycle times, and carbon footprint. Further challenges include delivery of wells and facility systems using less in-field construction hours at a lower baseline cost. The expectation is that the projects will also reduce typical greenhouse gas emissions compared with traditional pads. This paper will focus on the evolution of a mature field in a region that has been installing multilateral wells for over two decades. Wells originally drilled as dual-laterals have several years later been re-drilled as tri-lateral installations. As the wells once again reached the end of their expected production life, the use of re-entry multilateral technology has been utilized to extend field life for further economic production. This paper discusses three multilateral installations on the same subsea well over a 20-year period. It highlights the technology used to keep this well slot active for over two decades and the benefits of expanding the use of this technology as fields become slot restricted. It also highlights the benefits this technology delivers in enhancing reservoir exposure and the time savings brought by drilling new lateral legs in existing subsea wells without spending significant time having to first retrieve the xmas tree or tieback liner. The case study will include discussion of workover operations, completions, isolation methods, and lateral creation systems. Through three separate multilateral installations in one subsea slot, the production life has been extended beyond 20 years. The paper focuses on a particular multilateral well and the technology used to extend its production life past two decades. The paper also provides insight as to methodology for continually improving reliability of multilateral installations to maximize efficiencies.

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7

Kelsey, Matthew, Thomas Fanchin, Steffen Van Der Veen, and Marie Houge Nesheim. "Multilateral Re-Entry Technology Compounding Benefits and Extending Production Life Past Two Decades." In Offshore Technology Conference. OTC, 2022. http://dx.doi.org/10.4043/31855-ms.

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Abstract For over two decades multilateral technology has extended the production life of fields in the North Sea by continuing to evolve to meet the demands of increasingly complex deepwater applications. The use of multilateral technology delivers a higher recovery factor supported by the cumulative production of the multiple laterals. Over this history, multilateral applications have evolved from dual-laterals with standalone screens and commingled flow to the subject well of this paper whose slot has been kept active for over two decades through the use of re-entry multilateral systems. The well was originally completed as a dual-lateral and has since been recompleted twice to produce reserves previously left behind. As investment and availability of new fields decline, operators face challenges to extend the production life of mature fields while also working to reduce overall development cost, cycle times, and carbon footprint. Further challenges include delivery of wells and facility systems using less in-field construction hours at a lower baseline cost. The expectation is that the projects will also reduce typical greenhouse gas emissions compared with traditional pads. This paper will focus on the evolution of a mature field in a region that has been installing multilateral wells for over two decades. Wells originally drilled as dual-laterals have several years later been re-drilled as tri-lateral installations. As the wells once again reached the end of their expected production life, the use of re-entry multilateral technology has been utilized to extend field life for further economic production. This paper discusses three multilateral installations on the same subsea well over a 20-year period. It highlights the technology used to keep this well slot active for over two decades and the benefits of expanding the use of this technology as fields become slot restricted. It also highlights the benefits this technology delivers in enhancing reservoir exposure and the time savings brought by drilling new lateral legs in existing subsea wells without spending significant time having to first retrieve the xmas tree or tieback liner. The case study will include discussion of workover operations, completions, isolation methods, and lateral creation systems. Through three separate multilateral installations in one subsea slot, the production life has been extended beyond 20 years. The paper focuses on a particular multilateral well and the technology used to extend its production life past two decades. The paper also provides insight as to methodology for continually improving reliability of multilateral installations to maximize efficiencies.

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Reports on the topic "Tri-delivery"

1

Gaffney, Anne, Richard Boardman, Shannon Bragg-Sitton, Gary Groenewold, Daniel Ginosar, Jeff Aguiar, Gabriel Ilevbare, et al. Materials Challenges and Opportunities for Energy Generation, Conversion, Delivery, and Storage (Applied Energy Tri-Laboratory Consortium Workshop Report). Office of Scientific and Technical Information (OSTI), June 2021. http://dx.doi.org/10.2172/1785315.

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