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1

Nespoulous, C., P. Fabisch, A. Radunz, and G. H. Schmid. "Immunological Study on the Structural Difference between Ribulose- 1,5-bisphosphate Carboxylase/Oxygenase from Nicotiana tabacum var. John William's Broadleaf and the Tobacco Mutant Su/su." Zeitschrift für Naturforschung C 43, no. 9-10 (October 1, 1988): 717–26. http://dx.doi.org/10.1515/znc-1988-9-1014.

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Abstract In the present paper we have attempted to characterize by means of immunological methods the molecular difference between ribulose 1,5-bisphosphate carboxylase/oxygenase from the wild type TV. tabacum var. John William's Broadleaf and the tobacco mutant Su/su. The tobacco mutant Su/su exhibits in comparison to the wild type a higher photorespiratory activity. The reagents used in the present study are monospecific antisera to the two bifunctional enzymes to be compared. We have analyzed the oxygenase activity of the two enzymes in dependance on the binding of the amount of antibodies out of the homologous and the not homologous antiserum. These analyses have shown, that the enzymes of both phenotypes were 4 0 % stronger inhibited in the equivalence regions with respect to their oxygenase function by antibodies of the antiserum to ribulose 1,5-bisphosphate carboxylase/oxygenase of the mutant than by antibodies of the wild type antiserum. It should be noted that the antiserum to the mutant enzyme exhibits a 25 % lower antibody titer, than the antiserum to the wild type enzyme. In the region of extreme antibody excess, i.e. when antibodies are mostly monovalently bound and most antigenic determinants are saturated with antibodies, the oxygenase activity of both enzymes decreases towards zero in the presence of the homologous as well as in the presence of non-homologous antibodies. In the region of excess of antigenic determinants, that is when only a few antibody molecules can bind onto the enzymes, only the oxygenase activity of the mutant enzyme is inhibited by its homologous antibodies by 40 % . This apparent difference in the molecular structure of the two bifunctional enzymes to be compared is neither caught in the double immuno diffussion test nor in the tandem crossed immuno electrophoresis, using the two antisera as test reagents. In all cases only fused precipitation bands are observed. Chemical modification of ribulose 1,5-bisphosphate carboxylase/oxygenase by hydroxylamine treatment or treatment with o-(p-nitrophenyl)hydroxylamine or simple heating of the enzyme to 50 °C are immunologically characterized. As a consequence of such treatment considerably less antibodies are adsorbed. The strongest influence exerts a treatment with o-(p-nitrophenyl)-hydroxylamine with simultaneous heat treatment of the enzyme for 20 min at 50 °C.
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2

Lansdell, M. "15 years of practical sewage treatment in Venezuela." Water Science and Technology 33, no. 3 (February 1, 1996): 39–46. http://dx.doi.org/10.2166/wst.1996.0057.

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A summary of fifteen years of experience of the design, operation and performance several Venezuelan municipal wastewater treatment systems to serve a population of 5 million is presented. Technical and institutional problems which occurred during construction and operation are described and some of the solutions are presented. It was found that the most simple systems were the most effective and that it was important to develop solutions appropriate to local needs and avoid the technological dependance on imported spare parts.
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3

Sachs, David P. L. "Tobacco Dependence Treatment." Chest 129, no. 4 (April 2006): 836–39. http://dx.doi.org/10.1378/chest.129.4.836.

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4

Rajaram, Prashanth, Poornima C., Poornima G., and Shruthi R. "Treatment of Tobacco Dependence." Indian Journal of Contemporary Dentistry 1, no. 1 (2013): 53. http://dx.doi.org/10.5958/j.2320-5962.1.1.015.

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5

Burke, Michael V., Jon O. Ebbert, and J. Taylor Hays. "Treatment of Tobacco Dependence." Mayo Clinic Proceedings 83, no. 4 (April 2008): 479–84. http://dx.doi.org/10.4065/83.4.479.

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6

Kathuria, Hasmeena, Frank T. Leone, and Enid R. Neptune. "Treatment of tobacco dependence." Current Opinion in Pulmonary Medicine 24, no. 4 (July 2018): 327–34. http://dx.doi.org/10.1097/mcp.0000000000000491.

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7

OʼBRIEN, MAUREEN. "Certification in Tobacco Treatment." Home Healthcare Nurse: The Journal for the Home Care and Hospice Professional 25, no. 3 (March 2007): 162–66. http://dx.doi.org/10.1097/01.nhh.0000263433.85190.02.

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8

Fiore, Michael C. "Effective Tobacco Dependence Treatment." JAMA 288, no. 14 (October 9, 2002): 1768. http://dx.doi.org/10.1001/jama.288.14.1768.

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9

Chaibi, P., N. Magne, S. Breton, A. Chebib, J. Duron, M. Tagzirt, L. Hannoun, F. Piette, D. Khayat, and J. Spano. "Influence of geriatric consultation with Comprehensive Geriatric Assessment (CGA) on therapeutic decision in elderly cancer patients." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 9505. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.9505.

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9505 Background: Elderly patients represent an heterogeneous population in which anticancer therapeutic decision is often difficult and may be helped by CGA. We report 2 years activity of the geriatric assessment consultation of our institution, and its impact on therapeutic decision Methods: Since January 2007, we propose a geriatric consultation for elderly cancer patients for whom therapeutic decision appears complex to oncologists. This consultation included a CGA, with focuses on items like comorbidity, dependance, cognitive impairment, depression and malnutrition using international well known scales. Results: 161 patients (57 men, 104 women) (median age 82,4 years, extremes 73 -97) were seen at the geriatric consultation. Most of the patients (134/161) were in fist line treatment for colorectal (54), other digestive (28), breast (30) and pulmonary (14) cancers. Cancer was metastatic in 86 patients (53 %). Geriatric assessment found: severe comorbidity (grade 3 or 4 in CIRS-G scale) in 75 patients, dependance for at least one activity of daily living (ADL) in 52 patients, cognitive impairment in 42 patients, including 13 patients with already diagnosed Alzheimer disease, malnutrition in 104 patients (65 %), depression in 39 patients. According to prior oncologist decision, there have been no change in therapeutic decision in 29 patients only. Geriatric interventional treatment was delivered to 122 patients (76 %). Anticancer treatment was changed in 79 patients (49 %), including delayed therapy in 5 patients, less intensive therapy in 29 patients and more intensive therapy in 45 patients. Patients for whom final decision was delayed or less intensive therapy had significantly more frequent severe comorbidity (23/34, p < 0.01) and dependance for at least one ADL (19/34, p < 0.01). Patients for whom final decision was more intensive therapy had significantly more frequent metastatic disease (33/45, p < 0.01) Conclusions: Geriatric evaluation did influence therapeutic decision in 82 % of the patients. Follow up data will be presented to evaluate quality of final therapeutic decision, especially data concerning dose intensity and toxicity for patients with a more intensive therapy final decision. No significant financial relationships to disclose.
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10

Finlayson, A. J. Reid. "The Tobacco Dependence Treatment Handbook." Journal of Clinical Psychiatry 65, no. 5 (May 15, 2004): 727–28. http://dx.doi.org/10.4088/jcp.v65n0521b.

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11

Pbert, Lori, Jane Zapka, Denise G. Jolicoeur, Mary Jo White, Karin Valentine Goins, George Reed, and Judith K. Ockene. "Implementing State Tobacco Treatment Services." Health Promotion Practice 12, no. 6 (May 13, 2011): 802–10. http://dx.doi.org/10.1177/1524839910376035.

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This case study was conducted between 2000 and 2003 to examine the implementation of community based tobacco treatment programs funded by the Massachusetts Department of Public Health Tobacco Control Program (MTCP). Four dimensions of implementation, drawn from several models of program evaluation are explored: (a) quantity of services, (b) quality of services, (c) implementation/use of systems, and (d) sustainability. The quantity of services delivered was high, reflecting MTCP’s focus on increasing availability of services, particularly in underserved populations. The quality of physician-delivered tobacco intervention did not meet national benchmarks for delivery of all 5As (Ask, Advise, Assess, Assist, Arrange follow-up) and only about half of organizations reported routine systems for auditing tobacco use documentation. Implementation of systems to identify tobacco users and deliver tobacco treatment varied widely by community health settings, with low rates of tobacco use documentation found. Finally, in an era of greater competition for scarce prevention dollars, sustainability of services over time must be planned for from the outset, as indicated by the success of programs that sustained services by proactively and creatively incorporating tobacco treatment into their organizations. This case study can inform states’ policies in their design of tobacco treatment services in community health settings.
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12

Lewith, G. T. "The treatment of tobacco addiction." Complementary Therapies in Medicine 3, no. 3 (July 1995): 142–45. http://dx.doi.org/10.1016/s0965-2299(95)80054-9.

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13

Berlin, Ivan, Jean Perriot, and François Letourmy. "Tobacco Treatment Specialists in France." Journal of Smoking Cessation 4, no. 2 (December 1, 2009): 102–3. http://dx.doi.org/10.1375/jsc.4.2.102.

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14

Folan, Patricia A., Harlan R. Juster, Susan E. Lennon, Patricia J. Briest, and C. Beth Gero. "Improving Tobacco Dependence Treatment Delivery." American Journal of Preventive Medicine 49, no. 2 (August 2015): e9-e12. http://dx.doi.org/10.1016/j.amepre.2015.04.005.

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15

Harris, Debra S., and Robert M. Anthenelli. "Expanding treatment of tobacco dependence." Current Psychiatry Reports 7, no. 5 (September 2005): 344–51. http://dx.doi.org/10.1007/s11920-005-0034-3.

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16

Jarvik, Murray E., and Jack E. Henningfield. "Pharmacological treatment of tobacco dependence." Pharmacology Biochemistry and Behavior 30, no. 1 (May 1988): 279–94. http://dx.doi.org/10.1016/0091-3057(88)90456-x.

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17

Carlini, Beatriz H., Susan M. Zbikowski, Harold S. Javitz, T. Mona Deprey, Sharon E. Cummins, and Shu-Hong Zhu. "Telephone-Based Tobacco-Cessation Treatment." American Journal of Preventive Medicine 35, no. 1 (July 2008): 73–76. http://dx.doi.org/10.1016/j.amepre.2008.03.025.

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18

Hunt, Jamie J., A. Paula Cupertino, Susan Garrett, Peter D. Friedmann, and Kimber P. Richter. "How is tobacco treatment provided during drug treatment?" Journal of Substance Abuse Treatment 42, no. 1 (January 2012): 4–15. http://dx.doi.org/10.1016/j.jsat.2011.06.007.

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19

Beslic, Nermina, Sabrina Licina, Amera Sadija, and Renata Milardovic. "Incidence of Hypothyreoidism after Radioactive Iodine-I131 Treatment in Dependance of Hyperthyreoidism Etiology and Therapy Dose." Medical Archives 71, no. 4 (2017): 270. http://dx.doi.org/10.5455/medarh.2017.71.270-273.

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20

Guydish, Joseph, Kwinoja Kapiteni, Thao Le, Barbara Campbell, Erika Pinsker, and Kevin Delucchi. "Tobacco use and tobacco services in California substance use treatment programs." Drug and Alcohol Dependence 214 (September 2020): 108173. http://dx.doi.org/10.1016/j.drugalcdep.2020.108173.

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21

Perka, Edward J. "Culture Change in Addictions Treatment." Health Promotion Practice 12, no. 6_suppl_2 (November 2011): 159S—165S. http://dx.doi.org/10.1177/1524839911414410.

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Targeted training and technical assistance can have a major impact on the attitudes and beliefs of addiction service providers with respect to the treatment of tobacco dependency. Major gains have been made with the general public since the mid-1960s with respect to the reduction of tobacco use behavior and tobacco-related diseases. Tobacco use continues to be a major public health problem, and tobacco control initiatives are significantly affecting public attitudes and norms regarding tobacco use. There is, however, a specific population that has not benefited from these gains and, in fact, has been encouraged to continue smoking rather than make an attempt to quit. Individuals with a substance use disorder and/or mental health disorder have a much higher percentage of tobacco use than the general population, resulting in major health disparities. The addiction treatment and recovery community has lagged behind the general public in addressing tobacco use. New York State’s project, “Integrating Tobacco Use Interventions Into Chemical Dependence Services,” is a model that demonstrates how innovative regulations, and training and technical assistance developed specifically for addiction service providers, can initiate culture change with respect to tobacco use within addiction treatment settings, resulting in improved treatment outcomes and longer term stable recovery.
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22

McDaniel, Anna M., Renee M. Stratton, and Maria Britain. "Systems Approaches to Tobacco Dependence Treatment." Annual Review of Nursing Research 27, no. 1 (December 2009): 345–63. http://dx.doi.org/10.1891/0739-6686.27.345.

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Nurses have been at the forefront of initiatives to improve patient outcomes through systems change. Nursing research addressing systems approaches to treatment of tobacco dependence has demonstrated increased implementation of evidence-based practice guidelines. Existing health system research conducted by nurse scientists has focused on four strategies: tobacco use identification systems, education and training of nursing staff to deliver tobacco intervention, dedicated staff for tobacco dependence treatment in both acute and primary care settings, and institutional policies to support tobacco intervention. Nursing involvement in multidisciplinary health services research focusing on tobacco treatment has lagged behind advances in clinical nursing research of individual-focused smoking cessation interventions. Health information technology shows promise as part of an integrated approach to systems changes to support tobacco intervention, particularly in light of the current national emphasis on adoption and meaningful use of electronic health records. Future directions for translational research present unprecedented opportunity for nurse scientists to respond to the call for policy and systems changes to support tobacco treatment.
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23

Leone, Frank T., Sarah Evers-Casey, Mary A. Mulholland, and David P. L. Sachs. "Integrating Tobacco Use Treatment Into Practice." Chest 149, no. 2 (February 2016): 568–75. http://dx.doi.org/10.1378/chest.15-0441.

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24

Rigotti, Nancy A. "Treatment of Tobacco Use and Dependence." New England Journal of Medicine 346, no. 7 (February 14, 2002): 506–12. http://dx.doi.org/10.1056/nejmcp012279.

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25

Williams, Jill M., and Jonathan Foulds. "Successful Tobacco Dependence Treatment in Schizophrenia." American Journal of Psychiatry 164, no. 2 (February 2007): 222–27. http://dx.doi.org/10.1176/ajp.2007.164.2.222.

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26

Hughes, John R. "Tobacco Treatment Specialists: A New Profession." Journal of Smoking Cessation 2, S1 (December 1, 2007): 2–7. http://dx.doi.org/10.1375/jsc.2.supp.2.

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AbstractTobacco treatment specialists (TTS) are essential to developing an adequate system of treatment for smoking. Tobacco cessation treatment should be seen, not solely as a public health or prevention activity, but rather as a clinical activity. TTS should increase their professionalism by embracing evidence-based medicine. TTS should form professional organizations and credentialing bodies to insure a high quality professional identity.
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27

Thun, M. "Improving the treatment of tobacco dependence." BMJ 321, no. 7257 (August 5, 2000): 311–12. http://dx.doi.org/10.1136/bmj.321.7257.311.

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28

Sachs, D. P. L., and N. L. Benowitz. "Individualizing medical treatment for tobacco dependence." European Respiratory Journal 9, no. 4 (April 1, 1996): 629–31. http://dx.doi.org/10.1183/09031936.96.09040629.

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29

Shelley, Donna, Deanna Jannat-Khah, and Mark Wolff. "Tobacco-use treatment in dental practice." Journal of the American Dental Association 142, no. 6 (June 2011): 592–96. http://dx.doi.org/10.14219/jada.archive.2011.0229.

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30

Miranda, John. "Tobacco use in the treatment trenches." Alcoholism & Drug Abuse Weekly 32, no. 17 (April 24, 2020): 5–6. http://dx.doi.org/10.1002/adaw.32702.

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31

Hughes, John R. "Treatment Regulation in Promoting Tobacco Control." JAMA 299, no. 7 (February 20, 2008): 763. http://dx.doi.org/10.1001/jama.299.7.763-a.

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32

Berlin, Ivan. "Comorbidities and Tobacco Dependence Treatment Initiation." Nicotine & Tobacco Research 18, no. 8 (February 24, 2016): 1683. http://dx.doi.org/10.1093/ntr/ntw039.

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33

Sarna, Linda. "Resources for Treatment of Tobacco Dependency." Cancer Practice 8, no. 5 (September 2000): 248–53. http://dx.doi.org/10.1046/j.1523-5394.2000.85009.x.

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34

Kalkhoran, Sara, Neal L. Benowitz, and Nancy A. Rigotti. "Prevention and Treatment of Tobacco Use." Journal of the American College of Cardiology 72, no. 9 (August 2018): 1030–45. http://dx.doi.org/10.1016/j.jacc.2018.06.036.

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35

Shorstky, I. A., M. D. Sosnin, E. V. Gnuchikh, and E. E. Ulyanchenko. "Microplasma treatment for tobacco leaves drying." Processes and Food Production Equipment 14, no. 1 (2021): 25–33. http://dx.doi.org/10.17586/2310-1164-2021-14-1-25-33.

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36

Sheffer, Christine E., Thomas Payne, Jamie S. Ostroff, Denise Jolicoeur, Michael Steinberg, Sharon Czabafy, Jonathan Foulds, Matthew Bars, Ken Wassum, and Barbara Perry. "Increasing the Quality and Availability of Evidence-based Treatment for Tobacco Dependence through Unified Certification of Tobacco Treatment Specialists." Journal of Smoking Cessation 11, no. 4 (December 30, 2014): 229–35. http://dx.doi.org/10.1017/jsc.2014.30.

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Each year, tobacco use causes over 6 million deaths and is responsible for hundreds of billions of dollars in health care and economic costs in the world (WHO, 2011). If current trends continue, tobacco is expected to kill over 1 billion people in the 21st century, making it one of the single greatest causes of preventable death and disease in history (WHO, 2011). Long-term abstinence from tobacco use dramatically improves individuals’ health, reduces the incidence of tobacco-related disease, and is clearly responsible for saving lives (Anthonisen et al., 2005). Most tobacco users express a desire to achieve long-term abstinence from tobacco use and make numerous unsuccessful quit attempts over the course of many years (Borland, Partos, Yong, Cummings, & Hyland, 2012; CDC, 2011). Evidence-based treatments for tobacco use and dependence greatly improve the chances that quit attempts result in long-term abstinence (Chambless & Hollon, 1998; Chambless et al., 1998; Compas, Haaga, Keefe, Leitenberg, & Williams, 1998; Fiore et al., 2008; Zwar et al., 2004). Increasing the availability of high-quality evidence-based treatment for tobacco use and dependence will make it more likely that tobacco users use evidence-based treatments and that quit attempts translate into long-term abstinence. The professionalisation of treatment for tobacco dependence by the development of a rigorous, unified Tobacco Treatment Specialist (TTS) certification process will increase the availability of high-quality evidence-based treatment for tobacco use and dependence for all tobacco users.
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37

WILLIAMS, J., J. FOULDS, M. DWYER, B. ORDERCONNORS, M. SPRINGER, P. GADDE, and D. ZIEDONIS. "The integration of tobacco dependence treatment and tobacco-free standards into residential addictions treatment in New Jersey." Journal of Substance Abuse Treatment 28, no. 4 (June 2005): 331–40. http://dx.doi.org/10.1016/j.jsat.2005.02.010.

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38

Friend, Karen B., and David T. Levy. "Adoption of Tobacco Treatment Interventions by Substance-abuse-treatment Clinicians." Drugs: Education, Prevention and Policy 11, no. 1 (February 2004): 1–20. http://dx.doi.org/10.1080/0968763031000105038.

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39

Enyioha, Chineme, Graham W. Warren, Glen D. Morgan, and Adam O. Goldstein. "Tobacco Use and Treatment among Cancer Survivors." International Journal of Environmental Research and Public Health 17, no. 23 (December 6, 2020): 9109. http://dx.doi.org/10.3390/ijerph17239109.

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40

Hays, J. Taylor, and Jon O. Ebbert. "Bupropion for the Treatment of Tobacco Dependence." CNS Drugs 17, no. 2 (2003): 71–83. http://dx.doi.org/10.2165/00023210-200317020-00001.

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41

Fertig, Joanne B. "Overview-Alcohol and Tobacco: Mechanisms and Treatment." Alcoholism: Clinical and Experimental Research 26, no. 12 (December 2002): 1909–10. http://dx.doi.org/10.1111/j.1530-0277.2002.tb02499.x.

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42

Sobell, Mark B. "Alcohol and Tobacco: Clinical and Treatment Issues." Alcoholism: Clinical and Experimental Research 26, no. 12 (December 2002): 1954–55. http://dx.doi.org/10.1111/j.1530-0277.2002.tb02517.x.

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43

SARNA, LINDA, STELLA A. BIALOUS, VIRGINIA H. RICE, and MARY ELLEN WEWERS. "Promoting tobacco dependence treatment in nursing education." Drug and Alcohol Review 28, no. 5 (September 2, 2009): 507–16. http://dx.doi.org/10.1111/j.1465-3362.2009.00107.x.

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44

Mann, Lee S., Robert W. Johnson, and Daniel J. Levine. "Tobacco dependence: Psychology, biology, and treatment strategies." Psychosomatics 27, no. 10 (October 1986): 713–18. http://dx.doi.org/10.1016/s0033-3182(86)72621-2.

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45

Wewers, Mary Ellen, Linda Sarna, and Virginia Hill Rice. "Nursing Research and Treatment of Tobacco Dependence." Nursing Research 55, Supplement 1 (July 2006): S11—S15. http://dx.doi.org/10.1097/00006199-200607001-00003.

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46

Leone, Frank T., Sarah Evers-Casey, Benjamin A. Toll, and Anil Vachani. "Treatment of Tobacco Use in Lung Cancer." Chest 143, no. 5 (May 2013): e61S-e77S. http://dx.doi.org/10.1378/chest.12-2349.

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47

Hatsukami, Dorothy K., Joni Jensen, Raymond Boyle, Michael Grillo, and Robin Bliss. "Characteristics of smokeless tobacco users seeking treatment." Addictive Behaviors 24, no. 4 (July 1999): 551–57. http://dx.doi.org/10.1016/s0306-4603(98)00092-6.

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48

Raw, Martin, Judith Mackay, and Srinath Reddy. "Time to take tobacco dependence treatment seriously." Lancet 387, no. 10017 (January 2016): 412–13. http://dx.doi.org/10.1016/s0140-6736(15)00950-2.

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49

Warnakulasuriya, Saman, Gay Sutherland, and Crispian Scully. "Tobacco, oral cancer, and treatment of dependence." Oral Oncology 41, no. 3 (March 2005): 244–60. http://dx.doi.org/10.1016/j.oraloncology.2004.08.010.

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50

Zaparoli, Juçara Xavier, and José Carlos Fernandes Galduróz. "Treatment for tobacco smoking: A new alternative?" Medical Hypotheses 79, no. 6 (December 2012): 867–68. http://dx.doi.org/10.1016/j.mehy.2012.09.009.

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