Academic literature on the topic 'TRDMT1'

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Journal articles on the topic "TRDMT1"

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Yi, Xiaohua, Shuai He, Shuhui Wang, Haidong Zhao, Mingli Wu, Shirong Liu, and Xiuzhu Sun. "Detection of genetic variation and activity analysis of the promoter region of the cattle tRNA-modified gene <i>TRDMT1</i>." Archives Animal Breeding 64, no. 1 (April 30, 2021): 147–55. http://dx.doi.org/10.5194/aab-64-147-2021.

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Abstract. The tRNA modification gene in eukaryotes is relatively conservative. As an important modification gene, the TRDMT1 gene plays an important role in maintaining tRNA structural maintenance and reducing mistranslation of protein translation by methylation of specific tRNA subpopulations. Mouse and zebrafish TRDMT1 knockout experiments indicate that it may mediate growth and development through tRNA modification. However, there are no systematic reports on the function of tRNA-modified genes in livestock. In this study, Qinchuan cattle DNA pool sequencing technology was used. A G>C mutation in the −1223 bp position upstream of the TRDMT1 translation initiator codon was found. At this locus, the dual-luciferase assay indicated that different genotypes cause differences in transcriptional activity (P<0.05). Our experiment detected a natural genetic variation of a tRNA modification gene TRDMT1, which may provide potential natural molecular materials for the study of tRNA modification.
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Filip, Kamila, Anna Lewińska, Jagoda Adamczyk-Grochala, Antonella Marino Gammazza, Francesco Cappello, Marianna Lauricella, and Maciej Wnuk. "5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells." Cells 11, no. 7 (April 4, 2022): 1213. http://dx.doi.org/10.3390/cells11071213.

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5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellular stress responses such as apoptosis, autophagy, and senescence. The action of 5-azaC is complex and can be modulated by dose, time of treatment, and co-administration with oxidants. Insulinoma is a rare pancreatic neuroendocrine tumor with limited chemotherapeutic options. In the present study, two cellular models of insulinoma were considered, namely NIT-1 and β-TC-6 mouse cells, to evaluate the effects of 5-azaC post-treatment during hydrogen peroxide-induced oxidative stress. 5-azaC attenuated the development of oxidant-induced senescent phenotype in both cell lines. No pro-apoptotic action of 5-azaC was observed in cells treated with the oxidant. On the contrary, 5-azaC stimulated an autophagic response, as demonstrated by the increase in phosphorylated eIF2α and elevated pools of autophagic marker LC3B in oxidant-treated β-TC-6 cells. Notably, autophagy resulted in increased necrotic cell death in β-TC-6 cells with higher levels of nitric oxide compared to less affected NIT-1 cells. In addition, 5-azaC increased levels of RNA methyltransferase Trdmt1, but lowered 5-mC and m6A levels, suggesting Trdmt1 inhibition. We postulate that the 5-azaC anticancer action may be potentiated during oxidative stress conditions that can be used to sensitize cancer cells, at least insulinoma cells, with limited drug responsiveness.
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Ghanbarian, Hossein, Nicole Wagner, Beatrice Polo, Delphine Baudouy, Jafar Kiani, Jean-François Michiels, François Cuzin, Minoo Rassoulzadegan, and Kay-Dietrich Wagner. "Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth." PLOS ONE 11, no. 6 (June 6, 2016): e0156953. http://dx.doi.org/10.1371/journal.pone.0156953.

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Govindaraju, Gayathri, CA Jabeena, Devadathan Valiyamangalath Sethumadhavan, Nivethika Rajaram, and Arumugam Rajavelu. "DNA methyltransferase homologue TRDMT1 in Plasmodium falciparum specifically methylates endogenous aspartic acid tRNA." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860, no. 10 (October 2017): 1047–57. http://dx.doi.org/10.1016/j.bbagrm.2017.08.003.

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Sha, Chunli, Lu Chen, Li Lin, Taoqiong Li, Hong Wei, Meiling Yang, Wujiang Gao, et al. "TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure." Aging 13, no. 11 (June 8, 2021): 15193–213. http://dx.doi.org/10.18632/aging.203080.

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Betlej, Gabriela, Tomasz Ząbek, Anna Lewińska, Dominika Błoniarz, Iwona Rzeszutek, and Maciej Wnuk. "RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines." Journal of Bone Oncology 36 (October 2022): 100448. http://dx.doi.org/10.1016/j.jbo.2022.100448.

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Bloniarz, Dominika, Jagoda Adamczyk-Grochala, Anna Lewinska, and Maciej Wnuk. "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence." Aging 13, no. 12 (June 17, 2021): 15833–74. http://dx.doi.org/10.18632/aging.203203.

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Wnuk, Maciej, Piotr Slipek, Mateusz Dziedzic, and Anna Lewinska. "The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections." International Journal of Molecular Sciences 21, no. 21 (October 31, 2020): 8176. http://dx.doi.org/10.3390/ijms21218176.

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Eukaryotic 5-methylcytosine RNA methyltransferases catalyze the transfer of a methyl group to the fifth carbon of a cytosine base in RNA sequences to produce 5-methylcytosine (m5C). m5C RNA methyltransferases play a crucial role in the maintenance of functionality and stability of RNA. Viruses have developed a number of strategies to suppress host innate immunity and ensure efficient transcription and translation for the replication of new virions. One such viral strategy is to use host m5C RNA methyltransferases to modify viral RNA and thus to affect antiviral host responses. Here, we summarize the latest findings concerning the roles of m5C RNA methyltransferases, namely, NOL1/NOP2/SUN domain (NSUN) proteins and DNA methyltransferase 2/tRNA methyltransferase 1 (DNMT2/TRDMT1) during viral infections. Moreover, the use of m5C RNA methyltransferase inhibitors as an antiviral therapy is discussed.
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Xue, Songlei, Hui Xu, Zhen Sun, Hui Shen, Shihao Chen, Juan Ouyang, Qiqi Zhou, Xuming Hu, and Hengmi Cui. "Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration." Biochemical and Biophysical Research Communications 520, no. 1 (November 2019): 60–66. http://dx.doi.org/10.1016/j.bbrc.2019.09.098.

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Li, Zhengguang, Xiaolong Qi, Xu Zhang, Lei Yu, Lijuan Gao, Weining Kong, Wei Chen, et al. "TRDMT1 exhibited protective effects against LPS ‐induced inflammation in rats through TLR4‐NF‐κB / MAPK‐TNF ‐α pathway." Animal Models and Experimental Medicine 5, no. 2 (April 2022): 172–82. http://dx.doi.org/10.1002/ame2.12221.

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Dissertations / Theses on the topic "TRDMT1"

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FILIP, Kamila Maria. "Effects of 5-Azacitidine on Dnmt2/Trdmt1 expression levels and endoplasmic reticulum stress in cellular models of insulinoma." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/514949.

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Diabetes mellitus affects people all over the world of all ages or social groups making it a worldwide healthcare challenge. Moreover, untreated or badly treated diabetes carries a risk of serious complications including premature death (IDF Diabetes Atlas 9th edition, 2019). The main symptom of diabetes is insulin secretion and/or action disorder leading to hyperglycemia what results in impaired carbohydrate, fat, and protein metabolism (“Diagnosis and Classification of Diabetes Mellitus,” 2013). Dnmt2/ Trdmt1 in its structure and sequence is similar to DNA methyltransferases, however, it has been shown that mainly methylates aspartic acid transfer RNA, specifically at the cytosine-38 residue (Goll et al., 2006; Okano et al., 1998). tRNA methylation ensures accurate protein synthesis, tRNA structure stabilization, codon-anticodon interaction strengthening, and prevention from any mistakes in a frameshift (Hori, 2014). Different tRNA deficiency and various enzymes modifying ribonucleotides in tRNAs can disturb ER function. In the presented study we wanted to explore the potential role of 5-Azacitidine and Dnmt2/Trdmt1 in pancreatic β-cells. To investigate Trdmt1, ER stress, senescence, and aging and potential implications in diabetes insulin production and but also possible promotion of senescent cells elimination, insulinoma pancreatic β-cells were treated with two compounds: hydrogen peroxide, a wellknown pro-oxidant inducing aging, and SISP, and 5-Azacitidine, an inhibitor of DNA methylation and tRNA methylation suppressor at C38 position which is a major Trdmt1 target (Lewinska et al., 2018; Schaefer et al., 2009). In the presented study two insulin secreting pancreatic β-cell lines were treated with hydrogen peroxide and 5-Azacitidine. NIT-1 is an insulinoma cell line established from NOD/Lt (nonobese diabetic) mice and transgenic for the SV40 T-antigen. BetaTC6 is derived from insulinoma transgenic mice expressing SV40 T-antigen. Both cell lines secrete insulin in a response to the presence of glucose in the medium. Moreover, NIT-1 spontaneously develops type 1 diabetes what makes it a good model to understand T1D pathogenesis and treatment (Pearson et al., 2016; Poitout et al., 1995). Presented results indicate 5-AzaC mediated endoplasmic reticulum stress in pancreatic βcells thus UPR and UPS activation. 5-AzaC induced tRNA methylation inhibition at the Trdmt1 target site in T1D representative leads to ER stress mediated autophagy pathway which prevents apoptosis and maintains proliferation rate. Furthermore, 5-AzaC boosted 5 insulin production in the non-obese diabetic cell line. It has been shown that BetaTC6 cells are more vulnerable to stress and HP induced excessive NO production, ER stress, and related activation of apoptotic cell death pathway and decreased proliferation. Moreover, HP mediated premature senescence, signaling inhibition, and proliferation blockage of senescent cells indicates its senostatic activity and HP/5-AzaC mediated selective elimination of senescent cells treatment demonstrates senolytic activity. Additionally, Trdmt1 may help to cope with the cellular stress induction either by augmented translocation to the cytoplasm or increased biosynthesis. 5-AzaC modulates insulin secretion by senescent insulinoma cells and enhanced insulin production in the NOD cell line may be considered as a factor preventing T1D. The combined therapy of prooxidants and 5-AzaC can be studied as a promising candidate for insulinoma treatment.
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Darestani, Mostafa Yousefi. "Response of concrete pavements under moving vehicular loads and environmental effects." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16662/1/Mostafa_Yousefi_Darestani_Thesis.pdf.

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The need for modern transportation systems together with the high demand for sustainable pavements under applied loads have led to a great deal of research on concrete pavements worldwide. Development of finite element techniques enabled researchers to analyse the concrete pavement under a combination of axle group loadings and environmental effects. Consequently, mechanistic approaches for designing of concrete pavements were developed based on results of finite element analyses. However, unpredictable failure modes of concrete pavements associated with expensive maintenance and rehabilitation costs have led to the use of empiricalmechanistic approach in concrete pavement design. Despite progressive knowledge of concrete pavement behaviour under applied loads, concrete pavements still suffer from deterioration due to crack initiation and propagation, indicating the need for further research. Cracks can be related to fatigue of the concrete and/or erosion of materials in sub-layers. Although longitudinal, midedge and corner cracks are the most common damage modes in concrete pavements, Austroads method for concrete pavement design was developed based on traditional mid-edge bottom-up transverse cracking introduced by Packard and Tayabji (1985). Research presented in this thesis aims to address the most common fatigue related distresses in concrete pavements. It uses comprehensive finite element models and analyses to determine the structural behaviour of concrete pavements under vehicular loads and environmental effects. Results of this research are supported by laboratory tests and an experimental field test. Results of this research indicate that the induced tensile stresses within the concrete pavement are significantly affected by vehicle speed, differential temperature gradient and loss of moisture content. Subsequently, the interaction between the above mentioned factors and concrete damage modes are discussed. Typical dynamic amplifications of different axle groups are presented. A new fatigue test setup is also developed to take into consideration effects of pavement curvature on fatigue life of the concrete. Ultimately, results of the research presented in this thesis are employed to develop a new guide for designing concrete pavements with zero maintenance of fatigue damage.
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Darestani, Mostafa Yousefi. "Response of concrete pavements under moving vehicular loads and environmental effects." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16662/.

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The need for modern transportation systems together with the high demand for sustainable pavements under applied loads have led to a great deal of research on concrete pavements worldwide. Development of finite element techniques enabled researchers to analyse the concrete pavement under a combination of axle group loadings and environmental effects. Consequently, mechanistic approaches for designing of concrete pavements were developed based on results of finite element analyses. However, unpredictable failure modes of concrete pavements associated with expensive maintenance and rehabilitation costs have led to the use of empiricalmechanistic approach in concrete pavement design. Despite progressive knowledge of concrete pavement behaviour under applied loads, concrete pavements still suffer from deterioration due to crack initiation and propagation, indicating the need for further research. Cracks can be related to fatigue of the concrete and/or erosion of materials in sub-layers. Although longitudinal, midedge and corner cracks are the most common damage modes in concrete pavements, Austroads method for concrete pavement design was developed based on traditional mid-edge bottom-up transverse cracking introduced by Packard and Tayabji (1985). Research presented in this thesis aims to address the most common fatigue related distresses in concrete pavements. It uses comprehensive finite element models and analyses to determine the structural behaviour of concrete pavements under vehicular loads and environmental effects. Results of this research are supported by laboratory tests and an experimental field test. Results of this research indicate that the induced tensile stresses within the concrete pavement are significantly affected by vehicle speed, differential temperature gradient and loss of moisture content. Subsequently, the interaction between the above mentioned factors and concrete damage modes are discussed. Typical dynamic amplifications of different axle groups are presented. A new fatigue test setup is also developed to take into consideration effects of pavement curvature on fatigue life of the concrete. Ultimately, results of the research presented in this thesis are employed to develop a new guide for designing concrete pavements with zero maintenance of fatigue damage.
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Burgess, Alice Louise. "Conservation and function of RNA 5-methylcytosine in plants." Thesis, 2016. http://hdl.handle.net/2440/113323.

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Post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m⁵C) is an important modification that regulates RNA metabolism, translation and stress responses and occurs in both eukaryotes and prokaryotes. Yet, to date, no transcriptome-wide identification of m⁵C sites has been undertaken in plants. Here, we present over a thousand m⁵C sites transcriptome-wide in mRNAs and ncRNAs (non-coding RNAs) in three tissue types; siliques, shoots and roots of Arabidopsis thaliana at single nucleotide resolution using high-throughput Illumina sequencing of bisulfite treated RNA (RBS-seq). We show that m⁵C methylation sites can be tissue-specific, or shared among the tissue types investigated. Among the shared m⁵C sites, some are differentially regulated between tissue types, while others are constitutively methylated at the same level across all three tissue types. Within mRNAs, the majority of m⁵C sites are located within coding sequences. A small, significant enrichment of m⁵C sites in 3’UTRs of mRNAs was observed when normalizing for length and sequence coverage. We also investigated ncRNAs and demonstrate conservation of rRNA and tRNA m⁵C sites across six species in the kingdom Plantae, suggesting important and highly conserved roles of this post-transcriptional modification. We identified over 100 m⁵C sites in diverse RNA classes such as mRNAs, lncRNAs (long non-coding RNAs), snoRNAs (small nucleolar RNAs) and tRNAs mediated by Arabidopsis tRNA methyltransferase 4B (TRM4B) in siliques, shoots and roots. TRM4 plays broad roles in many organisms for mediating oxidative stress tolerance and balancing stem cell self-renewal and differentiation. We discovered that these roles are also conserved in plants, as Arabidopsis trm4b mutants have shorter primary roots, which is linked to a reduced capacity for cells to divide in the root meristem. Furthermore, trm4b mutants are also more sensitive to oxidative stress and have reduced stability of non-methylated tRNAs. Here, we extend the known m⁵C sites in tRNAs mediated by Transfer RNA aspartic acid methyltransferase 1 (TRDMT1) and find no evidence of m⁵C sites mediated by TRDMT1 in other RNA classes. Additionally we demonstrate that rRNA methylation requires the conserved RNA methyltransferase (RMTase) NSUN5. Our results also suggest functional redundancy of the three predicted RMTase NOP2 paralogs in Arabidopsis. This thesis provides the first maps of the Arabidopsis m⁵C epitranscriptome and characterization of Arabidopsis genetic mutants needed to further probe functions of this new layer of gene regulation in plants.
Thesis (Ph.D.) (Research by Publication) -- University of Adelaide, School of Biological Sciences, 2016.
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Kao, Ming-Hsuan, and 高旻暄. "Training Sequence Design for Channel Estimation in Uplink TRDMA System with Receive Beamforming." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/39272500666982383589.

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碩士
國立臺灣大學
電信工程學研究所
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This thesis is focus on the channel estimation of TRDMA system with receive beamforming. We address the problem of how to design a good train- ing sequence for this system and also address the problem that how BS could make a good training sequence assignment so that the multi-user interference (MUI) by way of the limitation resource of training sequence could be re- duce and mitigate. Our proposed method appropriately arranged the training sequence for users and make a good decision that some training sequence re- source could be reuse. This could be accommodate more and more users to estimate the channel in the same time. Simulation results show that the pro- posed method can reduce the channel estimation error than randomly assign sequence and the performance gap is clear to see when the number of user grow up. In the final, we further construct the uplink TRDMA transmission with receive beamforming, and simulate the BER. The performance of our proposed method is still better than randomly assign the training sequences and further verify that the concept of TRDMA system is more promising in the future.
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Books on the topic "TRDMT1"

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Balayan, Tigran. Trdat: Chʻapʻatso drama. Erevan: "Nairi", 1999.

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Trdat mets: Patmavep. Erevan: Amaras, 2001.

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Trdat Metsi khachě. Erevan: "Arevik", 1996.

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Santʻryan, Vanik. Askʻ Grigor Lusavorchʻi ev Trdat Metsi. Erevan: "Hrazdan-1" SPĚ, 1999.

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Nalbandyan, Varuzhan. Trdat III: Drama erku masitsʻ ev ině patkerov. Erevan: Anahit, 1997.

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Käsper, Kalle. Üksindus on hommikuti hell: Trdat See-ja-See-jani elu. [Tallinn]: Faatum, 1997.

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Trdat, Uzunean. Kutsal kitap İbranicesi okuma rehberi: Surbgrayin Ebrayerēni ěntʻertsʻanutʻean ughetsʻoytsʻ / Trdat Kʻhny. Uzunean. Istanbul: Hratarakutʻiwn Polsoy Patriarkʻutʻean, 2013.

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L, Manaseryan Ṛ. Hayastaně Artavazditsʻ minchʻev Trdat Mets: Artakʻin kʻaghakanutʻyun, petakan gaghapʻarabanutʻyan problemner ev kʻristoneutʻyan ěndunum. Erevan: "Areg", 1997.

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1930-50 Amer Trdmks. William Morrow & Company, 1991.

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Balayan, Tigran. Trdat: Chapatso drama. "Nairi", 1999.

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Book chapters on the topic "TRDMT1"

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Shekhar, Shashank, Shanidul Hoque, Ashraf Hossain, and Wasim Arif. "Performance Analysis of TRDMA Under Multi-path Rician Fading Channel." In Lecture Notes in Electrical Engineering, 677–88. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8234-4_54.

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"Combating Strong-Weak Resonances in TRDMA." In Wireless AI, 393–422. Cambridge University Press, 2019. http://dx.doi.org/10.1017/9781108597234.017.

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"VII. Des évêques et princes d'Arménie; quels d'entre eux sont élus primate et ont été établis chefs de sièges, par Trdat-Le-Grand et par S. Grégoire, par ses fils et petits-fils; titre particulier et rang des évêques de Siounie." In Histoire de la Siounie, edited by Marie-Félicité Brosset, 15–17. Piscataway, NJ, USA: Gorgias Press, 2013. http://dx.doi.org/10.31826/9781463229832-006.

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"V. Le pays de Siounie est éclairé de la connaissance de Dieu; ses princes croient en la divinité de J.-C., en môme temps que Trdat, par l'entremise de Grégoire, notre saint Illuminateur; les temples du fen sont détroits, les églises se bâtissent, nn évêqoe de Sioonie est sacré; antres notices utiles." In Histoire de la Siounie, edited by Marie-Félicité Brosset, 8–11. Piscataway, NJ, USA: Gorgias Press, 2013. http://dx.doi.org/10.31826/9781463229832-004.

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Conference papers on the topic "TRDMT1"

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Mokh, Ali, Ramin Khayatzadeh, Julien de Rosny, Mohamed Kamoun, Abdelwaheb Ourir, and Arnaud Tourin Mathias Fink. "Indoor Experimental Evaluation of Ultra-wideband MU-MISO TRDMA." In 2021 IEEE 93rd Vehicular Technology Conference (VTC2021-Spring). IEEE, 2021. http://dx.doi.org/10.1109/vtc2021-spring51267.2021.9448893.

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Feng Han and K. J. Ray Liu. "An interference cancellation scheme for the multiuser TRDMA uplink system." In 2013 IEEE Global Communications Conference (GLOBECOM 2013). IEEE, 2013. http://dx.doi.org/10.1109/glocom.2013.6831629.

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Umaisaroh, Halimah M. Mustika, Gamantyo Hendrantoro, and Takeshi Fukusako. "TRDMA multiuser downlink communication system over HF channels in equatorial region." In 2015 IEEE 4th Asia-Pacific Conference on Antennas and Propagation (APCAP). IEEE, 2015. http://dx.doi.org/10.1109/apcap.2015.7374395.

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Wang, Zhi-wen, Shao-zi Li, Mei-zhen Liu, and Qi-xian Cai. "Research of compress storage technique for C-TRDM." In 2009 IEEE International Symposium on IT in Medicine & Education (ITME2009). IEEE, 2009. http://dx.doi.org/10.1109/itime.2009.5236249.

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Cai, Qixian, Xiaolu Wang, and Ping Tan. "Temporal Data Store and Access Based on C-TRDM." In 2009 International Conference on Information Management, Innovation Management and Industrial Engineering. IEEE, 2009. http://dx.doi.org/10.1109/iciii.2009.159.

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Qixian, Cai, Huang Xiaolu, Cai Hongbo, and Pei Feng. "Mutual Temporal Data store approach based on C-TRDM." In 2010 2nd IEEE International Conference on Information Management and Engineering. IEEE, 2010. http://dx.doi.org/10.1109/icime.2010.5477627.

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Rudolph, J., S. Bergholz, K. Metzger, F. Silber, A. Klenk, and T. Müller. "Advanced Component Fatigue Monitoring Approaches Using the Example of a Boiler Recirculation Pump." In ASME 2020 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/pvp2020-21053.

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Abstract In the past, lifetime consideration of conventional power plant components focused on the creep behavior under internal pressure loading. Changing operating conditions towards flexible loads and load cycles as well as occurring damages underline the necessity to consider the fatigue and creep-fatigue behavior of the components. It is recommendable to integrate components such as boiler recirculation pumps into a fatigue monitoring program with continuous measurement of thermo-mechanical loads as a key feature. The paper describes the pilot fatigue monitoring of the boiler recirculation pump of block 8 of the GKM AG (including GKM, Framatome GmbH, KSB and MPA Stuttgart as actors). Thanks to the continuous data acquisition the thermal loading conditions were identified in much more detail than any available design data. The results of the measurement campaign were used for a qualified fatigue assessment based on the Fast Fatigue Evaluation (FFE) technology of Framatome. It was shown that the established monitoring approach (e.g. based on TRD301) is insufficient for complex geometries and loading conditions as it is the case for the boiler recirculation pump. The thermal loads as a consequence of temperature transients and temperature stratification are dominant. The consideration of these dominant loads in the fatigue assessment is indispensable. Based on a qualified fatigue evaluation approach reliable lifetime consumption, quantifications and extrapolations can be made for each component and fatigue relevant location. The FFE counts every closed cycle and allows for a continuous monitoring of the fatigue usage factor.
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Cai, Qixian, Hongbo Cai, Xiaolu Huang, and Zhiwen Wang. "Researching into the time filtration operator and temporal view based on the C-TRDM." In 2011 3rd International Conference on Computer Research and Development (ICCRD). IEEE, 2011. http://dx.doi.org/10.1109/iccrd.2011.5764010.

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