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1

Hyperacute xenograft rejection. New York: Springer-Verlag, 1995.

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2

Kelso, Anne. Cytokines in transplantation. Austin: R.G. Landes, 1996.

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3

Thayer, Meryman Harold, ed. Transplantation: Approaches to graft rejection : proceedings of the XVIII Annual Scientific Symposium of the American Red Cross, Washington, DC, April 28-30, 1986. New York: Liss, 1986.

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4

Alexander, J. Wesley. Transplantation tolerance induction. New York: Springer, 1996.

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5

Van den Elsen, Peter J., 1951-. The human T-cell receptor repertoire and transplantation. New York: Springer Verlag, 1995.

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6

L, Touraine J., Fondation Marcel Mérieux, and Université Claude Bernard, eds. Rejection and tolerance: Proceedings of the 25th Conference on Transplantation and Clinical Immunology, 24-26 May 1993. Dordrecht: Kluwer Academic Publishers, 1994.

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7

Takumi, Takeuchi, ed. The Th1, Th2 paradigm and transplantation tolerance. Austin: R.G. Landes, 1994.

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8

Conference on Transplantation and Clinical Immunology (28th 1996). Late graft loss: Proceedings of the 28th Conference on Transplantation and Clinical Immunology, 3-5 June, 1996. Dordrecht: Kluwer Academic Publishers, 1997.

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9

Conference on Transplantation and Clinical Immunology (29th 1997). Retransplantation: Proceedings of the 29th Conference on Transplantation and Clinical Immunology, 9-11 June 1997. Dordrecht: Kluwer Academic Publishers, 1998.

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10

Bone marrow transplantation across major genetic barriers. Hackensack, New Jersey [u.a.]: World Scientific, 2010.

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11

Narula, Jagat. Cardiac Allograft Rejection. Springer, 2012.

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12

H, Bach Fritz, and Auchincloss Hugh, eds. Transplantation immunology. New York: Wiley-Liss, 1995.

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13

(Editor), Sathia Thiru, and Herman Waldmann (Editor), eds. Pathology and Immunology of Transplantation and Rejection. Blackwell Publishers, 2001.

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14

(Editor), Nicholas L. Tilney, Terry B. Strom (Editor), and Leendert C. Paul (Editor), eds. Transplantation Biology: Cellular and Molecular Aspects. Lippincott Williams & Wilkins, 1996.

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15

L, Tilney Nicholas, Strom T. B, and Paul Leendert C, eds. Transplantation biology: Cellular and molecular aspects. Philadelphia: Lippincott-Raven, 1996.

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16

Transplantation: Approaches to graft rejection : Proceedings of the XVIII Annual Scientific Symposium of the American Red Cross, Washington, DC, April ... in clinical and biological research). Liss, 1986.

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17

Kobayashi, Takumi, and Riku Arai. Acute Rejection: Risk Factors, Management and Complications. Nova Science Publishers, Incorporated, 2013.

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18

1934-, Alexander J. Wesley, and Good Robert A. 1922-, eds. Transplantation tolerance induction. New York: Springer, 1996.

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19

1948-, Racusen Lorraine C., Solez Kim 1946-, and Burdick James F. 1941-, eds. Kidney transplant rejection: Diagnosis and treatment. 3rd ed. New York: M. Dekker, 1998.

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20

Philip, Hornick, and Rose Marlene L, eds. Transplantation immunology: Methods and protocols. Totowa, N.J: Humana Press, 2006.

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21

1946-, Solez Kim, Racusen Lorraine C. 1948-, and Billingham Margaret E. 1930-, eds. Solid organ transplant rejection: Mechanisms, pathology, and diagnosis. New York: Marcel Dekker, Inc., 1996.

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22

(Editor), Craig Halberstadt, and Dwaine F. Emerich (Editor), eds. Cellular Transplantation: From Laboratory to Clinic. Academic Press, 2006.

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23

Transplantation. Cold Spring Harbor Laboratory Press, 2014.

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24

G, Gubernatis, ed. Acute rejection of liver grafts. Austin: R.G. Landes, 1993.

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25

Craig, Halberstadt, and Emerich Dwaine F, eds. Cellular transplantation: From laboratory to clinic. Amsterdam: Elsevier Academic Press, 2007.

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26

(Editor), Craig Halberstadt, and Dwaine F. Emerich (Editor), eds. Cellular Transplantation: From Laboratory to Clinic. Academic Press, 2006.

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27

(Editor), J. L. Touraine, J. Traeger (Editor), H. Bétuel (Editor), J. M. Dubernard (Editor), J. P. Revillard (Editor), and C. Dupuy (Editor), eds. Rejection and Tolerance: Symposia Fondation Marcel Mérieux (Transplantation and Clinical Immunology). Springer, 1993.

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28

New immunosuppressive modalities and anti-rejection approaches in organ transplantation. Austin: R.G. Landes Co., 1994.

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29

Touraine, J. L. Transplantation And Clinical Immunology V21: LATE FAILURE AND CHRONIC REJECTION IN ORGAN TRANSPLANTATION (Discontinued (Symposia Foundation Merieux)). Edited by J. L. Touraine. Elsevier Science Publishing Company, 1990.

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30

E, Broxmeyer Hal, ed. Cellular characteristics of cord blood and cord blood transplantation. Bethesda, Md: AABB Press, 1998.

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31

C, Paul Leendert, and Solez Kim 1946-, eds. Organ transplantation: Long-term results. New York: Marcel Dekker, 1992.

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32

(Editor), Lawrence Rosenberg, and William P. Duguid (Editor), eds. Cellular Inter-Relationships in the Pancreas: Implications for Islet Transplantation (Medical Intelligence Unit). Chapman & Hall, 1996.

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33

(Editor), C. Ronco, Stefano Chiaramonte (Editor), and Giuseppe Remuzzi (Editor), eds. Kidney Transplantation: Strategies To Prevent Organ Rejection (Contributions to Nephrology). S. Karger AG (Switzerland), 2004.

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34

1941-, Burdick James F., ed. Kidney transplant rejection: Diagnosis and treatment. 2nd ed. New York: Dekker, 1992.

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35

Donna, Przepiorka, ed. New immunosuppressive drugs. Glenview, Ill. (P.O. Box 435, Glenview 60025): Physicians & Scientists Pub. Co., 1994.

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36

Solez, Kim, James F. Burdick, and Lorraine C. Racusen. Kidney Transplant Rejection: Diagnosis and Treatment (Kidney Disease, Vol. 9). 2nd ed. Marcel Dekker Inc, 1991.

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37

(Editor), J. L. Touraine, J. Traeger (Editor), H. Bétuel (Editor), J. M. Dubernard (Editor), J. P. Revillard (Editor), and C. Dupuy (Editor), eds. Retransplantation - Symposium Fondation Marcel Merieux. Springer, 1998.

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38

Muthukumar, Thangamani, Darshana Dadhania, Choli Hartono, and Manikkam Suthanthiran. Immunology, sensitization, and histocompatibility. Edited by Jeremy R. Chapman. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0279.

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Allograft rejection of the histo-incompatible allograft involves a highly orchestrated action of multiple cell types and mediators, with lymphocytes responsible for the identification of the foreignness of the allograft. The immune response directed against the donor is primarily, but not exclusively, directed at the donor’s major histocompatibility complex region class I and class II proteins. This chapter describes the immunobiology of the T cell and the role of human leucocyte antigens in clinical transplantation, thus identifying the targets for manipulation of the immune response by immune suppressants and through strategies designed to create a state of tolerance of the allograft.
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39

Stanislaw, Lukiewicz, and Zweier Jay L, eds. Nitric oxide in transplant rejection and anti-tumor defense. Boston: Kluwer Academic Publishers, 1998.

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40

P, Cronkite Eugene, Bond Victor P, Chandra Pradeep, Rai Kanti R, United States. Dept. of Energy., Brookhaven National Laboratory, and Associated Universities Inc, eds. Hematopoietic cellular proliferation: An international conference in honor of Eugene P. Cronkite. New York, N.Y: New York Academy of Sciences, 1985.

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41

Elsen, Peter Van Den. Human T Cell Recepter Repertoire and Trans. R G Landes Co, 1996.

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42

D, Galmarini, ed. Drugs and the liver: High risk patients and transplantation. Dordrecht: Kluwer Academic Publishers, 1993.

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43

Morris, Peter J., and Jeremy R. Chapman. The evolution of kidney transplantation. Edited by Jeremy R. Chapman. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0275.

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The history of kidney transplantation starts in 1902 with Ullman transplanting kidneys between dogs, and Carrel’s development of vascular anastomotic techniques. The developments in the 1950s in Boston, Paris, and the laboratories of Medawar and others demonstrated both proof of the principle and some of the barriers to clinical kidney transplantation. The 1960s laid the groundwork for organ preservation, immunosuppression, and histocompatibility leading to the creation of transplant units in many countries. In the 1970s, there was steady progress in understanding the immunology of allograft rejection and its suppression. The advent of azathioprine used with steroids in the early 1960s resulted in 1-year graft survival rates of around 60% and patient survival of 90% in good units. However, with the introduction of ciclosporin in the early 1980s, renal transplantation became an even more reliable renal replacement option as there was a dramatic reduction in the incidence of irreversible acute rejection. The 1990s saw the introduction of both better immunosuppression and better infection prophylaxis, which further improved patient outcomes. The first decade of the twenty-first century has been characterized by the promise of new technologies in many areas, only some of which have delivered clinical benefit. Molecular human leucocyte antigen (HLA) typing and detection of antibodies to HLA antigens, standardized immunosuppression and anti-infective prophylaxis, surveillance biopsy, and developing systems for increasing donation rates are delivering major benefits. Gene biomarkers, stem cell therapy, and tolerance protocols have yet to make an impact. This chapter describes the historical development of transplantation and how it has yielded the results delivered in clinical practice today.
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44

Johnson, R. W. G. Rational Use of Neoral Medicine. Royal Society of Medicine Press Ltd, 1996.

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45

Rational use of Neoral. London, UK: Royal Society of Medicine Press, 1996.

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46

T, Mohanakumar, ed. The role of MHC and non-MHC antigens in allograft immunity. Austin: R.G. Landes Co., 1994.

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47

Gardiner, Matthew D., and Neil R. Borley. Transplant surgery. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199204755.003.0014.

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This chapter begins by discussing the basic principles of immunology and transplant rejection and immunosuppression, before focusing on the key areas of knowledge, namely organ donation, renal transplantation, and transplantation of other organs. The chapter concludes with relevant case-based discussions.
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