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Tumin, Makmor, Khaled Tafran, Wan Ahmad Hafiz Wan Md Adnan, and Ahmad Farid Osman. "Assessing Countries’ Deceased Organ Donation and Transplantation Performance." MARCH 2023 19, no. 2 (March 13, 2023): 170–74. http://dx.doi.org/10.47836/mjmhs.19.2.25.
Introduction: Donors per million population and transplantations per million population are standardized, widely used indicators to assess and compare countries’ performance in organ donation and transplantation. This study aims to investigate these two particular metrics of organ donation and transplantation performance, and to introduce a new index, namely, ‘transplantations per patients on the waiting list’. Methods: Secondary analyses of data on 23 countries in 2016 were used to construct the transplantations per patients on the waiting list indicator for kidney, liver, pancreas, heart, and lung transplantation, as well as for the transplantation of any of the five aforementioned organs. Results: According to the transplantations per patients on the waiting list, the best-performing countries in terms of organ donation and transplantation are Belarus for kidney transplantation, Finland for liver and pancreas transplantation, Australia for heart transplantation, and France for lung transplantation. Considering all five organs together, Sweden, Australia, Finland, Austria, and Poland were the top five best-performing countries, followed by Spain in the sixth position. Conclusion: The deceased transplantations per patients on the waiting list can be an alternative indicator to assess performance, along with the widely-used donors and transplantations per million population, but still has its limitations in certain scenarios.
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Ratkovic, Marina, Nikolina Basic Jukic, Danilo Radunovic, Vladimir Prelevic, and Branka Gledovic. "Kidney Transplantation Program in Montenegro." BANTAO Journal 13, no. 2 (December 1, 2015): 68–72. http://dx.doi.org/10.1515/bj-2015-0015.
AbstractIntroduction.There was no transplantation program in Montenegro until 2012. On the other hand, there were 93 patients with transplanted kidney. These transplantations were performed abroad; 15% in areas of black organ markets (India, Pakistan, Russian Federation). Beside the ethical problems, these transplantations carried a high risk of complications.Methods.Our health system had to ensure solution for patients with terminal organ failure. Preparation of all neccessary conditions for the beginning of transplantation program in Montenegro started in 2006 with different activities including public, legal, medical, educational and international cooperation aspects.Results.The first kidney transplantation from living donor in Montenegro was preformed on September 25th, 2012. In the period from 2012 until now 23 kidney transplantations from living related donor were performed and one kidney transplantation from deceased donor in the Clinical Center of Montenegro. In the a two year-follow-up period, all patients to whom kidney transplantation was performed are in a good condition and without serious complications in posttransplant period.Conclusion.Development of the transplantation program allowed controlled transplantation and safety of patients. Our next steps are development of deceased organ donor transplantation and achievement of higher rate of deceased donor organ transplantation and individualization of immunosuppressive therapy.
Abstract Sickle cell disease (SCD) is the most common inherited hemoglobinopathy. Despite antenatal counseling and neonatal screening programs implemented in higher income countries, SCD is still associated with multiple morbidities and early mortality. To date, the only curative approach to SCD is hematopoietic stem cell transplantation, but this therapy is not yet established worldwide. The registries of the European Blood and Marrow Transplant (EBMT) and the Centre for International Blood and Marrow Transplant Research (CIBMTR) account, respectively, for 611 and 627 patients receiving transplantations for SCD. Most of these patients were transplanted with grafts from an HLA-identical sibling donor. The main obstacles to increasing the number of transplantations are a lack of awareness on the part of physicians and families, the absence of reliable prognostic factors for severity, and the perceived risk that transplantation complications may outweigh the benefits of early transplantation. Results show that more than 90% of patients having undergone an HLA-identical sibling transplantation after myeloablative conditioning are cured, with very limited complications. Major improvement is expected from the use of new reduced-toxicity conditioning regimens and the use of alternative donors, including unrelated cord blood transplantations and related haploidentical bone marrow or peripheral blood stem cell transplantations.
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Fatobene, Giancarlo, Vanderson Rocha, Andrew St. Martin, Mehdi Hamadani, Stephen Robinson, Asad Bashey, Ariane Boumendil, et al. "Nonmyeloablative Alternative Donor Transplantation for Hodgkin and Non-Hodgkin Lymphoma: From the LWP-EBMT, Eurocord, and CIBMTR." Journal of Clinical Oncology 38, no. 14 (May 10, 2020): 1518–26. http://dx.doi.org/10.1200/jco.19.02408.
PURPOSE To compare the outcomes of patients with Hodgkin or non-Hodgkin lymphoma undergoing nonmyeloablative haploidentical or unrelated cord blood (UCB) hematopoietic cell transplantation. PATIENTS AND METHODS We retrospectively studied 740 patients with Hodgkin lymphoma (n = 283, 38%) and non-Hodgkin lymphoma (n = 457, 62%) age 18-75 years who received transplantations from 2009 to 2016. Data were reported to the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation, Eurocord, or Center for International Blood and Marrow Transplant Research. Of the 526 patients who received haploidentical transplantation, 68% received bone marrow and 32% received peripheral blood. All patients received a uniform transplantation conditioning regimen (2 Gy of total-body irradiation, cyclophosphamide, and fludarabine) and graft-versus-host disease prophylaxis (calcineurin inhibitor and mycophenolate). In addition, patients who received a haploidentical transplantation received posttransplantation cyclophosphamide. RESULTS Compared with haploidentical bone marrow and peripheral-blood transplantations and adjusted for age, lymphoma subtype, and disease status, survival was lower after UCB transplantation (hazard ratio [HR], 1.55; P = .001; and HR, 1.59; P = .005, respectively). Similarly, progression-free survival was lower after UCB transplantations compared with haploidentical bone marrow and peripheral-blood transplantations (HR, 1.44; P = .002; and HR, 1.86; P < .0001), respectively. The 4-year overall and progression-free survival rates after UCB transplantation were 49% and 36%, respectively, compared with 58% and 46% after haploidentical bone marrow transplantation and 59% and 52% after peripheral-blood transplantation, respectively. Lower survival was attributed to higher transplantation-related mortality after UCB transplantation compared with haploidentical bone marrow and peripheral-blood transplantation (HR, 1.91; P = .0001; and HR, 2.27; P = .0002, respectively). CONCLUSION When considering HLA-mismatched transplantation for Hodgkin or non-Hodgkin lymphoma, the data support haploidentical related donor transplantation over UCB transplantation.
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Gautier, S. V., and S. M. Khomyakov. "ORGAN DONATION AND TRANSPLANTATION IN RUSSIAN FEDERATION IN 2015. 8th report of National Register." Russian Journal of Transplantology and Artificial Organs 18, no. 2 (June 25, 2016): 6–26. http://dx.doi.org/10.15825/1995-1191-2016-2-6-26.
Aim. To carry out monitoring of the organization and development of the organ donation and transplantation in theRussian Federationaccording to 2015.Materials and methods. Questioning of heads of all the centers of transplantation is carried out. The comparative analysis of the obtained data in dynamics by years, between certain regions of theRussian Federation, the transplantation centers is done.Results. According to the register in2015 inthe Russian Federation 36 centers of renal transplantation, 17 centers of liver transplantation and 10 centers of heart transplantation were functioning. The waiting list of kidney transplantation in 2015 included 4167 potential recipients that make 13% of the total number of the patients (31 500) receiving a dialysis. The rate of donor activity in 2015 made 3.0 pmp. Efficiency of donor programs in 2015 continues to increase: the share of multiorgan retrievals made 57.8%, average number of organs, received from one effective donor, made 2.7. In 2015 the rate of kidney transplantation made 6.5 pmp; the rate of liver transplantation made 2.2 pmp; the rate of heart transplantation made 1.2 pmp. The number of transplantations of liver and heart in theRussian Federationcontinues to increase. The number of transplantations of kidney remains approximately at one level in the range of 950–1050.Moscowcapital region continues to be the center of stability and development of the organ donation and transplantation in the country, in which 10 centers of transplantation are functioning and nearly a half from all kidney transplantations and more than 65% of all liver and heart transplantations are carried out.Conclusion. The potential for further development of the transplantation care in theRussian Federationcontinues to persist. In particular, at the expense of increasing efficiency of regional donation programs, expanding practices of multiorgan recuperation and transplantations of extrarenal organs, through interregional transplant coordination. It is critical to keep the volumes of the state order to deliver transplantological medical care to the population and to implement federal funding to conduct donation programs.
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Gajewski, James L., Viviana V. Johnson, S. Gerald Sandler, Antoine Sayegh, and Thomas R. Klumpp. "A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation." Blood 112, no. 8 (October 15, 2008): 3036–47. http://dx.doi.org/10.1182/blood-2007-10-118372.
Abstract The increased use of hematopoietic progenitor cell (HPC) transplantation has implications and consequences for transfusion services: not only in hospitals where HPC transplantations are performed, but also in hospitals that do not perform HPC transplantations but manage patients before or after transplantation. Candidates for HPC transplantation have specific and specialized transfusion requirements before, during, and after transplantation that are necessary to avert the adverse consequences of alloimmunization to human leukocyte antigens, immunohematologic consequences of ABO-mismatched transplantations, or immunosuppression. Decisions concerning blood transfusions during any of these times may compromise the outcome of an otherwise successful transplantation. Years after an HPC transplantation, and even during clinical remission, recipients may continue to be immunosuppressed and may have critically important, special transfusion requirements. Without a thorough understanding of these special requirements, provision of compatible blood components may be delayed and often urgent transfusion needs prohibit appropriate consultation with the patient's transplantation specialist. To optimize the relevance of issues and communication between clinical hematologists, transplantation physicians, and transfusion medicine physicians, the data and opinions presented in this review are organized by sequence of patient presentation, namely, before, during, and after transplantation.
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Meirelles Júnior, Roberto Ferreira, Paolo Salvalaggio, Marcelo Bruno de Rezende, Andréia Silva Evangelista, Bianca Della Guardia, Celso Eduardo Lourenço Matielo, Douglas Bastos Neves, et al. "Liver transplantation: history, outcomes and perspectives." Einstein (São Paulo) 13, no. 1 (March 2015): 149–52. http://dx.doi.org/10.1590/s1679-45082015rw3164.
In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two patients who had undergone liver transplantation. In 1989, Starzl et al. reported a series of 1,179 consecutives patients who underwent liver transplantation and reported a survival rate between one and five years of 73% and 64%, respectively. Finally, in 1990, Starzl et al. reported successful use of tacrolimus in patents undergoing liver transplantation and who had rejection despite receiving conventional immunosuppressive treatment. Liver Transplantation Program was initiated at Hospital Israelita Albert Einstein in 1990 and so far over 1,400 transplants have been done. In 2013, 102 deceased donors liver transplantations were performed. The main indications for transplantation were hepatocellular carcinoma (38%), hepatitis C virus (33.3%) and alcohol liver cirrhosis (19.6%). Of these, 36% of patients who underwent transplantation showed biological MELD score > 30. Patient and graft survival in the first year was, 82.4% and 74.8%, respectively. A major challenge in liver transplantation field is the insufficient number of donors compared with the growing demand of transplant candidates. Thus, we emphasize that appropriated donor/receptor selection, allocation and organ preservation topics should contribute to improve the number and outcomes in liver transplantation.
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Gautier, S. V., Ya G. Moysyuk, and S. M. Khomyakov. "ORGAN DONATION AND TRANSPLANTATION IN THE RUSSIAN FEDERATION IN 2014 7th REPORT OF NATIONAL REGISTER." Russian Journal of Transplantology and Artificial Organs 17, no. 2 (May 26, 2015): 7–22. http://dx.doi.org/10.15825/1995-1191-2015-2-7-22.
Aim. To carry out monitoring of the organization and development of organ donation and transplantation in the Russian Federation according to 2014. Materials and methods. Questioning of heads of all the centers of transplantation is carried out. The comparative analysis of the obtained data in dynamics of years, between certain regions of the Russian Federation, the transplantation centers, and also with data of the international registers is made. Results. According to the Register in 2014 in the Russian Federation functioned 36 centers of kidney transplantation, 14 centers of liver transplantation and 9 centers of heart transplantation. The waiting list of kidney transplantation in 2014 included 4636 potential recipients that makes 16% of total number of the patients 29 000 receiving dialysis. The rate of donor activity in 2014 made 3.2 per million population (pmp). Efficiency of donor programs in 2014 continued to increase: the share of effective donors after brain death in 2014 increased to 77.2%, the share of multiorgan explantation made 50.5%, average number of organs received from one effective donor made 2.6. In 2014 the rate of kidney transplantation made 7.0 pmp, the rate of liver transplantation made 2.1 pmp and the rate of heart transplantation made 1.1 pmp. In the Russian Federation the number of transplantations of liver and heart continues to increase. The significant contribution to development of the organ donation and transplantation brings the Moscow region in which 11 centers of transplantation function and nearly a half from all kidney transplantations and more than 65% of all liver and heart transplantations are carried out. Conclusion. In theRussian Federation the potential for further development of the transplantology remains. In particular, at the expense of increase in the efficiency of regional donation programs, introduction of technologies, expansion of the practices of multiorgan donation and transplantations of extrarenal organs, interregional transplant coordination. Preservation of volumes of public funding for transplantological medical care and federal financing of donation programs in regions are of great importance.
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Pinchuk, A. V., N. V. Shmarina, I. V. Dmitriev, V. E. Vinogradov, and A. I. Kazantsev. "Analysis of recipient and graft survival after primary and second kidney transplantation." Russian Journal of Transplantology and Artificial Organs 23, no. 2 (July 12, 2021): 21–29. http://dx.doi.org/10.15825/1995-1191-2021-2-21-29.
Objective: to evaluate the 1- and 5-year graft and recipient survival after primary and second kidney transplantation, to compare the outcomes depending on the age of recipients.Material and methods. The treatment outcomes for 364 patients who underwent kidney transplantation at Sklifosovsky Research Institute of Emergency Care, Moscow over the period from 2007 to 2019. Of these, 213 patients underwent kidney transplantation for the first time, while 151 patients were having a second transplantation. We analyzed the effect of previous transplants, as well as the age of the recipients on long-term survival rates.Results. No significant difference in 1- and 5-year survival of kidney recipients after primary and second transplantations was found. In contrast, the long-term graft survival significantly depended on this criterion and turned out to be significantly higher after primary transplantations. The 1- and 5-year survival of older recipients was lower than the survival of younger recipients after primary and second kidney transplantation. The 1-year graft survival after primary kidney transplantation was higher in young recipients than in older recipients of the same group, however, but there were no significant differences in the 5-year graft survival. After second transplantations, there were no significant differences in the 1- and 5-year graft survival depending on the age of recipients.Conclusion. A history of previous transplantation is an important factor in kidney transplantation outcome, which must be taken into account in clinical practice.
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Gautier, S. V., and S. M. Khomyakov. "Organ donation and transplantation in the Russian Federation in 2016 9th report of the National Registry." Russian Journal of Transplantology and Artificial Organs 19, no. 2 (June 23, 2017): 6–26. http://dx.doi.org/10.15825/1995-1191-2017-2-6-26.
Aim. To carry out monitoring of the organization and tendencies in the development of organ donation and transplantation in the Russian Federation in 2016. Materials and methods. Questioning of the heads of all the centers of transplantation is carried out. The comparative analysis of the obtained data in dynamics of the years, between certain regions of the Russian Federation and transplantation centers is done. Results. According to the register 35 centers of kidney transplantation, 22 centers of liver transplantation and 11 centers of heart transplantation were functioning in the Russian Federation in 2016. The waiting list of kidney transplantation in 2016 included 4818 potential recipients that make 14% of total number of the patients (35 000) receiving dialysis. The rate of donor activity in 2016 made 3.3 p. m. p. Efficiency of donor programs in 2016 continued to increase: the share of multiorgan retrieval made 64.1%, average number of organs received from one effective donor made 2.7. In 2016 the rate of kidney transplantation made 7.4 p. m. p., the rate of liver transplantation made 2.6 p. m. p.; the rate of heart transplantation made 1.5 p. m. p. In 2016 the number of transplantations in the Russian Federation increased by 14.8% in comparison with 2015 having overcome the level of 1700 organs transplantation. The Moscow region still remains to be the core of stability and development of the organ donation and transplantation in the country where 10 centers of transplantation function and half of all kidney transplantations and more than 70% of all liver and heart transplantations are carried out. Conclusion. The results of 2016 were positively affected by the introduction of targeted financial support of medical activity, related to organ donation, from federal budget resources. Among unresolved problems which constrain the development there are collision of legal regulation of licensing of medical activities for organ donation and transplantation, lack of the state order for the organization of transplantological medical care in each region, lack of responsibility of the heads of the regions and medical organizations for the organization of organ donation. Positive tendencies of the development of organ donation and transplantation in Russia call for further monitoring, strengthening and building.
Mari, Elisabeth Rose. "Factors affecting the induction of transplantation tolerance in bone marrow transplantation." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9919.
The engraftment of allogeneic haematopoietic stem cells (HSC) relies on the use partially or fully myeloablative regimens to condition the transplant recipient in order to “make space” in the bone marrow microenvironment and establish immunological tolerance to donor alloantigens. In murine models of bone marrow transplantation where donor-recipient pair differ for a single minor histocompatibility (H) antigen, HY, engraftment can be obtained using low-dose irradiation. Such conditioning favours the homeostatic expansion of regulatory (Treg) cells that play a crucial role in generating host versus graft tolerance (HvG). However, the HY model has some limitations because, in the clinical setting, HLA-matched donor and recipient still differ for several minor H antigens. Although there is evidence that immune responses across minor H differences concentrate on immunodominant epitopes, it was fundamental to understand whether increasing the number of donor antigenic disparities necessitated a proportional increment in the dose of conditioning to achieve engraftment. I utilised a bone marrow transplantation model in which donor and recipient differed for multiple minor H antigens and whereby immune responses were prominently skewed against a single immunodominant epitope. Recipient mice were C57BL/6 and bone marrow was obtained from BALB.B donors, whereby the immunodominant epitope was H60. My results showed that low-dose irradiation was not sufficient to obtained BALB.B donor cell engraftment but a fully myeloablative dose of (850cGy) was required. When the amount of antigenic determinants was decreased, by transplanting (BALB.BxC57BL/6) F1 cells, donor cell engraftment was achieved at an irradiation dose of 500cGy. These data show that the dose of conditioning regimen required for engraftment is proportional to the magnitude of the antigenic differences across donor and recipient. Different doses of myeloablation certainly bear different impacts on the depletion of lymphocyte subsets and lympho-haemopoietic reconstitution. Therefore, I investigated the kinetics and extent of Treg expansion. In all groups of transplanted mice the engrafted mice had significantly increased proportions of Treg cells which peaked during the second week post-transplant. When host Treg cells were depleted prior to transplantation with male C57BL/6 or (BALB.BxC57BL/6) F1 donor bone marrow under irradiated at 500cGy or 600cGy, the level of donor cell engraftment was not affected. However, there was a delay in the engraftment of (BALB.BxC57BL/6) F1 bone marrow, thus suggesting a marginal role for Treg cells using higher doses of conditioning. These data imply that the magnitude of antigenic disparities between the donor and recipient deeply impacts on the dose of irradiation required to obtain durable engraftment. The dose of irradiation does not correlate with the level of Treg cell expansion and Treg depletion only marginally affects engraftment. These data indicate that, in the presence of multiple antigenic disparities, depletion of T cell effecting HvG responses rather than induction of immune regulation is necessary.
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Poyet, Pierre. "Les reflux vésico-urétéraux en transplantation rénale : A propos de 9 reflux concernant 408 transplantations." Saint-Etienne, 1990. http://www.theses.fr/1990STET6217.
Lord, Stephen. "Reinnervation after cardiac transplantation." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410568.
Hyperlipidemia is prevalent following heart transplantation, and may play a role in the development of late graft atherosclerosis. The charts of 35 heart transplant recipients (n = 32 males and 3 females) were reviewed retrospectively up until three years post transplantation, to describe a time-course of hypercholesterolemia after transplantation, and to determine the mechanisms involved in its pathogenesis. All patients received prednisone, cyclosporine, and azathioprine for immunosuppression. A progressive rise in both serum cholesterol (2.4 $ pm$ 0.4 mmol/l, p $<$ 0.01), and body weight (8.4 $ pm$ 1.6 kg, p $<$ 0.01) were observed during the first 8 and 10 months respectively. Levels stabilized thereafter, remaining above pretransplant levels. Triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol concentrations were all above normal limits following transplantation. Tapering of prednisone dose had a significant effect on serum cholesterol levels, whereas diet had a beneficial effect on body weight. A randomized, controlled, dietary intervention study then followed to further assess the effect of dietary intervention on minimizing or preventing post transplantation hyperlipidemia and weight gain. Five patients were counselled the Step One Lipid-Lowering diet, two patients were controls. All study patients demonstrated a lower overall increase in serum cholesterol levels than other transplant recipients. Reported nutritional intakes were similar between both groups. Increases in body weight were related to increases in body fat. Patients in the diet group demonstrated improvements in their level of nutrition knowledge, which correlated with lower serum cholesterol levels. Changes in serum cholesterol were also associated with appetite, hunger, perceived interest, perceived benefits, perceived barriers, and attitudes toward food. Changes in body weight were associated with appetite, hunger, perceived barriers, and stress. As
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Honey, Karen J. "Mechanisms of transplantation tolerance." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301519.
Jamieson, N. V. "Liver preservation for transplantation." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605054.
Nagel, Eckhard, and Petra Schmidt. Transplantation. Edited by Rudolf Pichlmayr. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-80042-9.
Kleinberger, Gunther, Kurt Lenz, Rudolf Ritz, Hans-Peter Schuster, and F. Stockenhuber, eds. Transplantation. Vienna: Springer Vienna, 1995. http://dx.doi.org/10.1007/978-3-7091-7678-8.
Reddi, Alluru S. "Transplantation." In Absolute Nephrology Review, 421–75. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22948-5_11.
Orosz, Charles G., M. Elaine Wakely, Ginny L. Bumgardner, and Elora J. Weringer. "Transplantation." In In Vivo Models of Inflammation, 265–90. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-7775-6_11.
Gilbert-Barness, Enid, Diane E. Spicer, and Thora S. Steffensen. "Transplantation." In Handbook of Pediatric Autopsy Pathology, 581–91. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6711-3_21.
Raja, Deepak. "Transplantation." In Encyclopedia of Ophthalmology, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-35951-4_819-1.
Haase, Hajo. "Transplantation." In Immunologie für Einsteiger, 175–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44843-4_12.
Zain, Jasmine. "Transplantation." In Cancer Treatment and Research, 269–87. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99716-2_13.
Georgiev, Vassil St. "Transplantation." In National Institute of Allergy and Infectious Diseases, NIH, 693–708. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-297-1_44.
Holzman, Robert S., Thomas J. Mancuso, Navil F. Sethna, and James A. DiNardo. "Transplantation." In Pediatric Anesthesiology Review, 441–62. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-1617-4_29.
You, J. Y., S. Park, J. B. Turowski, K. McCurry, and A. C. Mehta. "Lung Transplantation Following a Heart Transplantation." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6334.
"Abstracts of the 31st Annual Meeting of the German Transplantation Society, Erlangen, Germany, 29 September–1 October 2022." In 31st Annual Meeting of the German Transplantation Society. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88976-968-1.
Barr, Earl T., Mark Harman, Yue Jia, Alexandru Marginean, and Justyna Petke. "Automated software transplantation." In ISSTA '15: International Symposium on Software Testing and Analysis. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2771783.2771796.
Thomas, J., D. Emerson, Q. Chen, J. Malas, S. Premananthan, A. Krishnan, J. Chikwe, et al. "Robotic Lung Transplantation." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6333.
Páramo, J. A., R. Arcas, J. Fernández, J. Herreros, R. Llorens, and E. Rocha. "FIBRINOLYSIS AFTER HEART TRANSPLANTATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643114.
Some aspects of the function of the fibrinolytic system were investigated in 12 patients undergoing cardiac transplantation. Plasminogen, euglobulin fibrinolytic activity (EFA), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor activity (PAI),α2-antiplasmin (α2-Ap) and fibrinogen degradation products (FDP) were determined preo-peratively and on postoperative days 1 and 5. Results showed a significant decrease of plasminogen (p <0.005), EFA (p <0.0001) and t-PA (p ^.0.001) on postoperative day 1 as compared to the baseline value, followed by recovery on day 5. There was a significant increase of PAI (p < 0 . 005) , α2-AP (p <0.0001) and FDP (p < 0.02) on postoperative day 1 as compared to the preoperative value. PAI and FDP reached the baseline value on postoperative day 5, but α2AP also increased on postoperative day 5. Our data show that there is an impairment in blood fibrinolytic activity early after cardiac transplantation, mainly related to a decrease of plasminogen and t-PA and a increase of PAI and α2AP. The clinical relevance of these data needs further evaluation.
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Pritsker, A. Alan B., Michael E. Kuhl, John P. Roberts, Margaret D. Allen, James F. Burdick, David L. Martin, Janet S. Reust, et al. "Organ transplantation policy evaluation." In the 27th conference. New York, New York, USA: ACM Press, 1995. http://dx.doi.org/10.1145/224401.224813.
Staiano, M. T., C. Alberto, M. Sacco, C. Donatella, C. De Angelis, G. M. Saracco, R. Romagnoli, and S. Martini. "Pancreatic cystic neoplasm prevalence in liver transplantation candidates and post-transplantation outcome." In ESGE Days 2024. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/s-0044-1783024.
Erickson, Geoffrey R., Jeffrey M. Gimble, Dawn Franklin, and Farshid Guilak. "Adipose Tissue-Derived Stromal Cells Grown in Three-Dimensional Aliginate Constructs Display a Chondrogenic Phenotype." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2503.
Abstract Articular cartilage is the connective tissue that lines the surfaces of diarthrodial joints in the human body. Because cartilage is avascular, aneural, and alymphatic, it has a limited capacity for repair. Techniques such as microfracture, transplantation of autologous cartilage, and allograft or xenograft transplantations have not proven fully effective in treating cartilage damage. Current therapy is focusing on cell-based treatments such as autologous chondrocyte transplantation [1,2]. However, this method faces several limitations, as the donor site can provide a limited number of cells and the harvesting procedure itself may cause significant local morbidity. The goal of this study was to examine the chondrogenic potential of an autologous source of undifferentiated stromal cells derived from subcutaneous fat. It has been shown that chondrocytes embedded in a three-dimensional matrix retain a differentiated phenotype and produce cartilage-associated proteins [3]. In addition, it has been shown that alginate or agarose can support the formation of an extracellular matrix over time [4,5]. The goal of this study was to examine the chondrogenic potential of adipose-derived stromal cells with the ultimate goal of developing a “tissue engineering” method to regenerate articular cartilage.
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Manca, Camilla, Alexandre Candolo, Cintia Albino, Emerson Rafael Lopes, João Victor Feliciano, Laila Fortunato, and Murilo Moura. "INVASIVE FUNGAL INFECTION BY TRICHOSPORON ASAHII IN A PATIENT SUBMITTED TO HAPLOIDENTICAL HEMATOPOIETIC CELL TRANSPLANTATION FOR RELAPSED ACUTE MYELOID LEUKEMIA." In Anual Meeting of the Brazilian Society of Bone Marrow Transplantation. Journal of Bone Marrow Transplantation and Cellular Therapy, 2020. http://dx.doi.org/10.46765/2675-374x.2020v3n1.
Cassino, Theresa R., Masaho Okada, Lauren Drowley, Johnny Huard, and Philip R. LeDuc. "Mechanical Stimulation Improves Muscle-Derived Stem Cell Transplantation for Cardiac Repair." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192941.
Muscle-derived stem cells (MDSCs) have been successfully transplanted into both skeletal (1) and cardiac muscle (2) of dystrophin-deficient (mdx) mice, and show potential for improving cardiac and skeletal dysfunction in diseases like Duchenne muscular dystrophy (DMD). Our previous study explored the regeneration of dystrophin-expressing myocytes following MDSC transplantation into environments with distinct blood flow and chemical/mechanical stimulation attributes. After MDSC transplantation within left ventricular myocardium and gastrocnemius (GN) muscles of the same mdx mice, significantly more dystrophin-positive fibers were found within the myocardium than in the GN. We hypothesized that the differences in mechanical loading of the two environments influenced the transplantation and explored whether using MDSCs exposed to mechanical stimulation prior to transplantation could improve transplantation. Our study shows increased engraftment into the heart and GN muscle for cells pretreated with mechanical stretch for 24 hours. This increase was significant for transplantation into the heart. These studies have implications in a variety of applications including mechanotransduction, stem cell biology, and Duchenne muscular dystrophy.
Reports on the topic "Transplantation":
1
Cohen, Isaac. Megakaryocytopoiesis in Stem Cell Transplantation. Fort Belvoir, VA: Defense Technical Information Center, October 1997. http://dx.doi.org/10.21236/adb233503.
Fallon, John, Richard Dumbill, and Peter Friend. Organ preservation in renal transplantation. BJUI Knowledge, September 2023. http://dx.doi.org/10.18591/bjuik.0753.
Brännström, Mats, Ylva Carlsson, and Henrik Hagberg. Obstetric outcome after uterus transplantation. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2023.1.0052.
Review question / Objective: Is delivery by elective cesarean section as safe for the mother and the neonate after uterus transplantation as after delivery by elective cesarean section for reasons such as breech and psychological indication regarding stillbirth/neonatal mortality, neonatal morbidity, maternal mortality, and morbidity? Rationale: To compare pregnancy, obstetrical and neonatal complications at delivery by cesarean section in patients that have undergone uterus transplantation and in a normal groups of women.
4
Coppo, Patricia A., Judy W. Davis, and Steve M. Spellman. HLA Typing for Bone Marrow Transplantation. Fort Belvoir, VA: Defense Technical Information Center, January 2007. http://dx.doi.org/10.21236/ada462775.
Spellman, Stephen. HLA Typing for Bone Marrow Transplantation. Fort Belvoir, VA: Defense Technical Information Center, July 2011. http://dx.doi.org/10.21236/ada546709.
Setterholm, Michelle, Judy W. Davis, and Steve M. Spellman. HLA Typing for Bone Marrow Transplantation. Fort Belvoir, VA: Defense Technical Information Center, October 2007. http://dx.doi.org/10.21236/ada473611.
There is a growing debate over organ transplantation which is a successive therapeutic option for the treatment of end-stage organ diseases but the ethical issues associated with the shortage of transplantable organs must also be taken into account.
8
Villamaria, C. Y., T. E. Rasmussen, J. R. Spencer, S. Patel, and M. R. Davis. Characterization and Optimization of Auto-Transplantation and Allo-transplantation of Free Composite Tissue for Reconstruction of Battlefield Injuries. Fort Belvoir, VA: Defense Technical Information Center, January 2014. http://dx.doi.org/10.21236/ada592171.
Reshef, Ran. Chemokine Receptor Signatures in Allogeneic Stem Cell Transplantation. Fort Belvoir, VA: Defense Technical Information Center, August 2014. http://dx.doi.org/10.21236/ada610688.
Woelders, Henri. Gene banking and transplantation of (mammalian) ovarian tissue. Wageningen: Centre for Genetic Resources, the Netherlands (CGN), Wageningen University & Research, 2020. http://dx.doi.org/10.18174/514882.
