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1

Hlscher, Christian. Neuronal Mechanisms of Memory Formation: Concepts of Long-term Potentiation and Beyond. Cambridge: Cambridge University Press, 2000.

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2

Georg, Hertting, Spatz Hanns-Christof, and North Atlantic Treaty Organization. Scientific Affairs Division., eds. Modulation of synaptic transmission and plasticity in nervous systems. Berlin: Springer-Verlag, 1988.

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3

The cerebellum: Brain for an implicit self. Upper Saddle River, N.J: FT Press, 2012.

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4

Synaptic plasticity: Dynamics, development and disease. Wien: Springer, 2012.

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5

Tomas, Hökfelt, Fuxe Kjell, Pernow Bengt, and Marcus Wallenberg Foundation for International Cooperation in Science., eds. Coexistence of neuronal messengers: A new principle in chemical transmission : proceedings of the Marcus Wallenberg Symposium, held at the Grand Hotel, Saltsjöbaden, Stockholm, on 26-28 June, 1985. Amsterdam: Elsevier, 1986.

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6

Taupin, Philippe. The hippocampus: Neurotransmission and plasticity in the nervous system. New York: Nova Biomedical Books, 2007.

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7

Nonsynaptic diffusion neurotransmission and late brain reorganization. New York: Demos, 1995.

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8

(Foreword), Per Anderson, Michel Baudry (Editor), and Joel L. Davis (Editor), eds. Long-Term Potentiation, Vol. 1: A Debate of Current Issues. The MIT Press, 1991.

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9

Michel, Baudry, and Davis Joel 1948-, eds. Long-term potentiation: A debate of current issues. Cambridge, Mass: MIT Press, 1991.

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10

Apergis-Schoute, John, Geoffrey Burnstock, Michael P. Nusbaum, David Parker, Miguel A. Morales, Louis-Eric Trudeau, and Erik Svensson, eds. Neuronal Co-transmission. Frontiers Media SA, 2019. http://dx.doi.org/10.3389/978-2-88945-945-2.

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11

R, Wolpaw Jonathan, Schmidt John T, and Vaughan Theresa M, eds. Activity-driven CNS changes in learning and development. New York, N.Y: New York Academy of Sciences, 1991.

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12

R, Wolpaw Jonathan, Schmidt John T, Vaughan Theresa M, State University of New York at Albany., and New York Academy of Sciences., eds. Activity-driven CNS changesin learning and development. New York, N.Y: New York Academy of Sciences, 1991.

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13

Neuronal Noise. Springer, 2012.

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14

W, Winlow, ed. Neuronal communications. Manchester: Manchester University Press, 1990.

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15

Neuronal cytoskeleton: Morphogenesis, transport and synaptic transmission. Tokyo: Japan Scientific Societies Press, 1993.

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16

Heinemann, Uwe. Calcium Electrogenesis and Neuronal Functioning. Springer, 2011.

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17

H, Ehrlich Yigal, ed. Molecular mechanisms of neuronal responsiveness. New York: Plenum Press, 1987.

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18

Christian, Hölscher, ed. Neuronal mechanisms of memory formation: Concepts of long-term potentiation and beyond. Cambridge: Cambridge University Press, 2001.

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19

Levine, Michael S., Elizabeth A. Wang, Jane Y. Chen, Carlos Cepeda, and Véronique M. André. Altered Neuronal Circuitry. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199929146.003.0010.

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In mouse models of Huntington’s disease (HD), synaptic alterations in the cerebral cortex and striatum are present before overt behavioral symptoms and cell death. Similarly, in HD patients, it is now widely accepted that early deficits can occur in the absence of neural atrophy or overt motor symptoms. In addition, hyperkinetic movements seen in early stages are followed by hypokinesis in the late stages, indicating that different processes may be affected. In mouse models, such behavioral alterations parallel complex biphasic changes in glutamate-mediated excitatory, γ‎-aminobutyric acid (GABA)-mediated inhibitory synaptic transmission and dopamine modulation in medium spiny neurons of the striatum as well as in cortical pyramidal neurons. The progressive electrophysiologic changes in synaptic communication that occur with disease stage in the cortical and basal ganglia circuits of HD mouse models strongly indicate that therapeutic interventions and strategies in human HD must be targeted to different mechanisms in each stage and to specific subclasses of neurons.
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20

Gillies, Andrew, David Willshaw, David Sterratt, and Bruce Graham. Principles of Neuronal Modelling. Cambridge University Press, 2008.

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21

1944-, Heinemann U., and Lux H. Dieter, eds. Calcium electrogenesis and neuronal functioning. Berlin: Springer-Verlag, 1986.

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22

Tatsuno, Masami. Analysis and Modeling of Coordinated Multi-neuronal Activity. Springer, 2014.

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23

Tatsuno, Masami. Analysis and Modeling of Coordinated Multi-neuronal Activity. Springer, 2016.

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24

Serena, Dudek, ed. Transcriptional regulation by neuronal activity: To the nucleus and back. New York: Springer, 2007.

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25

K, Kaczmarek Leonard, and Levitan Irwin B, eds. Neuromodulation: The biochemical control of neuronal excitability. New York: Oxford University Press, 1987.

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26

(Editor), Leonard K. Kaczmarek, and Irwin B. Levitan (Editor), eds. Neuromodulation: The Biochemical Control of Neuronal Excitability. Oxford University Press, USA, 1986.

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27

Fuxe, Kjell, Sweden) Marcus Wallenberg Symposium (1985 Saltsjobaden, and Tomas Hokfelt. Coexistence of Neuronal Messengers: A New Principle in Chemical Transmission (Progress in Brain Research). Elsevier Publishing Company, 1987.

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28

Phosphoproteins in Neuronal Functions (Progress in Brain Research). Elsevier, 1987.

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29

Hirokawa, Nobutaka. Neuronal Cytoskeleton: Morphogenesis, Transport, and Synaptic Transmission (Taniguchi Symposia on Brain Sciences, No 16). CRC, 1994.

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30

Bates, David, and Nima Bassiri. Plasticity and Pathology: On the Formation of the Neural Subject. Fordham University Press, 2016.

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31

Plasticity and Pathology: On the Formation of the Neural Subject. Fordham University Press, 2016.

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32

Bates, David, and Nima Bassiri. Plasticity and Pathology: On the Formation of the Neural Subject. Fordham University Press, 2016.

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33

Sala, Carlo, and Michael R. Kreutz. Synaptic Plasticity: Dynamics, Development and Disease. Springer, 2012.

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34

G, Shulman R., and Rothman D. L, eds. Brain energetics and neuronal activity: Applications to fMRI and medicine. Chichester: Wiley, 2004.

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35

(Editor), Robert G. Shulman, and Douglas L. Rothman (Editor), eds. Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine. Wiley, 2004.

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36

Josef, Kittler, and Moss Stephen 1962-, eds. The dynamic synapse: Molecular methods in ionotropic receptor biology. Boca Raton: CRC/Taylor & Francis, 2006.

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37

(Editor), Josef T. Kittler, and Stephen J. Moss (Editor), eds. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology (Frontiers in Neuroscience). CRC, 2006.

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38

The dynamic synapse: Molecular methods in ionotropic receptor biology. Boca Raton, FL: CRC/Taylor & Francis, 2006.

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39

G, Burdet, Combe Philippe 1940-, and Parodi O, eds. Neuronal information processing: From biological data to modelling and applications : Cargèse, France, 30 June-12 July 1997. Singapore: World Scientific, 1999.

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40

F, Kaiser Tim, and Peters Felix J, eds. Synaptic plasticity: New research. New York: Nova Science Publishers, 2008.

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41

Mason, Peggy. Perceiving the World. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0014.

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As exemplified by sensory illusions, perception is interpretative rather than faithfully representational of the changes in the world. All perceptual pathways involve stimulus transduction, transmission, and modulation before sensory events are coded by the nervous system. The set of stimuli that humans respond to are a subset of the stimuli that elicit reactions across the animal kingdom. The brain processes visual, auditory, mechanical, and vestibular stimuli by breaking stimuli into their sinusoidal components for neuronal processing. The probabilistic response of sensory receptors to stimulation within a receptive field is described. A fundamental property of sensory perception is responsiveness to a wide range of stimulus intensities over several orders of magnitude. Yet, at any one time, the response to a stimulus is proportional to the background level of stimulation. The concept of labeled line sensory transmission is described, and the reality of multimodal integration is revealed through examples.
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42

M, Nitsch Roger, and International Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting, eds. Alzheimer's disease: Amyloid precursor proteins, signal transduction, and neuronal transplantation. New York, N.Y: New York Academy of Sciences, 1993.

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43

Gaitanis, John, Phillip L. Pearl, and Howard Goodkin. The EEG in Degenerative Disorders of the Central Nervous System. Edited by Donald L. Schomer and Fernando H. Lopes da Silva. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228484.003.0013.

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Nervous system alterations can occur at any stage of prenatal or postnatal development. Any of these derangements, whether environmental or genetic, will affect electrical transmission, causing electroencephalogram (EEG) alteration and possibly epilepsy. Genetic insults may be multisystemic (for example, neurocutaneous syndromes) or affect only the brain. Gene mutations account for inborn errors of metabolism, channelopathies, brain malformations, and impaired synaptogenesis. Inborn errors of metabolism cause seizures and EEG abnormalities through a variety of mechanisms, including disrupted energy metabolism (mitochondrial disorders, glucose transporter defect), neuronal toxicity (amino and organic acidopathies), impaired neuronal function (lysosomal and peroxisomal disorders), alteration of neurotransmitter systems (nonketotic hyperglycinemia), and vitamin and co-factor dependency (pyridoxine-dependent seizures). Environmental causes of perinatal brain injury often result in motor or intellectual impairment (cerebral palsy). Multiple proposed etiologies exist for autism, many focusing on synaptic development. This chapter reviews the EEG findings associated with this myriad of pathologies occurring in childhood.
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44

H, Yu Albert C., ed. Neuronal-astrocytic interactions: Implications for normal and pathological CNS function. Amsterdam: Elsevier, 1992.

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45

L, Pichler Florian, ed. Neural pathways research. New York: Nova Science Publishers, 2008.

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46

Spike Timing: Mechanisms and Function. Taylor & Francis Group, 2013.

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47

Hendrik, Gispen Willem, Routtenberg Aryeh, United States. Air Force. Office of Scientific Research., and International Workshop on "Phosphoproteins in Neuronal Function" (2nd : 1985 : State University of Utrecht), eds. Phosphoproteins in neuronal function: Proceedings of the second international workshop at the State University of Utrecht, September 1985. Amsterdam: Elsevier, 1986.

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48

Sajikumar, Sreedharan. Synaptic Tagging and Capture: From Synapses to Behavior. Springer, 2016.

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49

Sajikumar, Sreedharan. Synaptic Tagging and Capture: From Synapses to Behavior. Springer, 2014.

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50

David, Evered, and Whelan Julie, eds. Plasticity of the neuromuscular system. Chichester: Wiley, 1988.

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