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1

Chung, Seung-Wook. "Modeling and analysis of the transforming growth factor beta signaling pathway." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 115 p, 2008. http://proquest.umi.com/pqdweb?did=1597632591&sid=15&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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2

Porteous, C. "Epidermal growth factor, α-transforming growth factor and breast cancer". Thesis, University of Aberdeen, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383650.

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Evidence exists that epidermal growth factor (EGF) and alpha transforming growth factor (αTGF) are important in breast cancer. An inverse relationship between epidermal growth factor receptor (EGF-R) and oestrogen receptor (ER) has been reported by some, (1) but not all workers (2). The aim in this thesis was to develop assays to measure, levels of EGF, and determine EGF-R status in human breast tumours. These results were then correlated with each other, with ER and node status and histological grade (Bloom & Richardson). An additional aim in this thesis was to develop a source of αTGF in con
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3

Smith, Cheryl A. "Skeletal muscle injury, fibrosis and transforming growth factor-[beta]." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1744.

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Thesis (Ph. D.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains xii, 146 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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4

Gu, Ye. "Homo & heterodimeric TGF-[beta] family growth factors." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610106.

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5

Lanxon-Cookson, Erinn Claire. "Lovastatin decreases TGF-ß1 concentration of glomerular endothelial cells cultured in high glucose." Online access for everyone, 2008. http://www.dissertations.wsu.edu/Thesis/Spring2008/e_lanxon_cookson_040308.pdf.

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6

Zhang, Min Fen. "The role of milk transforming growth factor-[beta](TGF-[beta]) in the development of the infant gut and gut mucosal immune system." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phz51.pdf.

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In title, [beta] is represented by the Greek letter. Copies of author's previously published articles inserted. Errata pages pasted onto back end-paper. Bibliography: leaves 104-137. Studies milk TGF-[beta] and its receptors in the post-natal gut using a rat model to investigate a link between milk TGF-[beta] and the development of the infant gut and gut mucosal immune system. Finds maternal milk may be a major source of TGF-[beta] to the immature gut and may react with receptors on the cells of the mucosal immune system along the gastro-intestinal tract, modulating infant mucosal immune respo
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7

Pascal, M. M. "The role of transforming growth factor beta and other growth factors in the development of diabetic retinopathy." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593270.

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The present study showed that TFG-β mRNA and protein expression is regulated by glucose concentration in HREC. Maximal secreted protein levels and mRNA were produced at a concentration of 15 mM and the majority of the TGF-β is found in an active form in these cells. These results were novel and specific as HREC have not been shown before to express TFG-β in response to glucose. TGF-β appears to be central to a wide range of pathological features involved in the disease and this first study highlights a possible important role for TGF-β in the mechanism of induction of microvascular abnormaliti
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8

Kam, Siu-kei Christy. "The role of TGF-[beta] signaling in the initiation of TNF-[beta] expression in human PBMC derived macrophages." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38746049.

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9

Kam, Siu-kei Christy, та 甘笑琪. "The role of TGF-{221} signaling in the initiation of TNF-α expression in human PBMC derived macrophages". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38746049.

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10

Ni, Xueying. "Activin and a putative novel activin receptor-like kinase in the human placenta." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39215.pdf.

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11

Tajsić, Tamara. "Nuclear envelope proteins modulate Transforming growth factor β superfamily signalling". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610759.

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12

Chaudhury, Arindam. "Transforming growth factor-beta (TGFß)-mediated post-transcriptional regulation of epithelial-mesenchymal transdifferentiation (EMT)." Cleveland, Ohio : Cleveland State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1268963035.

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Thesis (Ph.D.)--Cleveland State University, 2010.<br>Abstract. Title from PDF t.p. (viewed on April 15, 2010). Includes bibliographical references (p. 151-187). Available online via the OhioLINK ETD Center and also available in print.
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13

Liu, Xiaoying. "Molecular mechanisms of myofibroblast differentiation and the role of TGF beta1, TNF alpha, and thrombin signal transduction." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1236711907.

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14

Helterline, Deri Lila Icenoggle. "Embryonic and tissue-specific regulation of myostatin-1 and -2 gene expression in zebrafish." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Thesis/Spring2006/d%5Fhelterline%5F050106.pdf.

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15

Liu, Ye. "Generation and utilization of knockout mice to elucidate the functions of the TGF-[beta] pathway in mammalian endodermal specification and placental development." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1158673346.

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16

Festing, Maria Helen. "Generation of novel conditional and hypomorphic alleles of the Smad2 gene and the effects of Smad2 removal in environments with elevated retinoid signaling." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180467148.

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17

Wu, Xuewei, and 吴雪伟. "Isthmin, a novel extracellular regulator in nodal signaling pathway." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://sunzi.lib.hku.hk/hkuto/record/B45586573.

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18

Mei, Jie, and 梅節. "The physiological role of transforming growth factor-beta in gastrointestinal development in the pig." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29960861.

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19

Glinsmann-Gibson, Betty Jean 1961. "Molecular mechanism of autocrine regulation by TGF-alpha in T(3)M(4) human pancreatic carcinoma cells." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/277113.

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The human pancreatic cancer cell line T3M4, is known to produce transforming growth factor-alpha (TGF-alpha); as well as overexpress the receptor for this ligand, epidermal growth factor (EGF) receptor. TGF-alpha messenger RNA (mRNA) levels were assayed using northern blot, after addition of epidermal growth factor or TGF-alpha. The level of TGF-alpha mRNA was found to increase 2-fold at 2 hours and then return to near basal levels at 10 hours, after treatment with either ligand. Both ligands were also equipotent in a 2 hour dose response assay, with half maximal stimulation seen at 1 nM and m
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20

Emmanuel, Catherine. "Apoptotic And Morphometric Synergies Between Tumour Necrosis Factor-A And Transforming Growth Factor-B1 For Human Endothelial Cells." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/4864.

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21

Boelaert, Kristien. "Pituitary tumor transforming gene (PTTG) and related growth factors in endocrine tissues." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424097.

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22

Lam, Sze-man Joyce. "Expression of transforming growth factors (TGF-alpha and TGF-beta 1) on postmortem skin wounds /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38480566.

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23

Fong, Sitt Wai. "The effects of transforming growth factor-β2 on synaptic transmission at the mammalian neuromuscular junctions". Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=133996.

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Transforming growth factor-βs (TGF-βs) are highly expressed in neural development but why the adult nervous system continues to express them is unclear. TGF-β2 is concentrated at mature neuromuscular junctions (NMJs) of mammalian skeletal muscle fibres, and the nerve terminal expresses TβR-II receptors. To test the role of TGF-β2 at mammalian NMJs, I performed four experiments. The first study tested whether TGF-β2 acutely modulates synaptic transmission at mature mammalian NMJs. Second, I asked if chronically reduced TGF-β2 expression disrupts synaptic transmission. Third, I asked if TGF-β2’s
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24

O'Keeffe, Fiona. "The effects of Pitx3 and GDF-5 on the generation and survival of midbrain dopaminergic neurons." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610732.

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25

Cheung, Ho-ki, and 張可琪. "Detection and characterization of transforming growth factor beta (TGF-?) and betaglycan in porcine and human milk." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29275805.

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26

Lee, B. C. Bob. "Probing the molecular mechanisms of how polymorphisms in Cerberus-like result in low bone mineral density." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39711481.

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27

Sheils, Emma. "The TGF-β signalling pathway in Trichinella spiralis : phylogenetic and functional analysis of TGF-β ligands". Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=184012.

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The release of genome sequence information is revolutionising the study of helminth parasites by providing important datasets for comparative genomics, allowing the comprehensive analysis of signalling pathways that regulate nematode development. Much of the current knowledge of nematode signalling pathways is based on studies of the free-living model Caenorhabditis elegans. The recent availability of the Trichinella spiralis genome sequence presented an opportunity to study signalling pathways of this, and other, parasitic nematodes, providing a phylum-wide overview of a given signalling path
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28

Wang, Feng. "The role of TGFBI in development and cancer." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610043.

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29

Odhiambo, John F. "Evaluation of weaning regimen and seminal plasma biology on reproductive management in cattle." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6057.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains ix, 122 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 99-122).
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30

Wang, Qian. "Role of growth factors in regulating of lens fibre differentiation." Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28141.

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The lens is a good developmental biology model owing to its simplicity and distinct polarity. The anterior lens compartment constitutes a monolayer of cuboidal-shaped epithelial cells, which overly a mass of precisely aligned elongated fibre cells. Lens growth throughout life is mediated by proliferation of epithelial cells and their subsequent differentiation into fibres, to form a transparent and tightly-packed lens. During lens growth and development, cell proliferation is mainly restricted to a specialised region at the periphery of the lens epithelium known as the gerrninative zone.
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31

Woodward, Terry L. "Inhibition of cellular proliferation by retinoids and transforming growth factor-betas in bovine mammary cells correlates with increased connexin43 expression." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40283.

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Bovine fibroblasts and epithelial cells were isolated from surgically biopsied mammary tissue. Characterization of population doubling time, cytoskeletal intermediate filaments, cryopreservation survival, and viability were performed on all fibroblast and epithelial cells. Several clonal fibroblast cell lines were cotransfected with a plasmid bearing the SV-40 Large-T-antigen, and the pSV-2 neo plasmid. Transfected cells were subsequently selected with G418 sulfate and cloned.<br>MAC-T cells and non-clonal primary bovine mammary epithelial cells proliferated in response to IGF-I, insulin, seru
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32

To, Man-yan. "Potential oncogenic role of FOXGI in ovarian cancer." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557856.

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33

Yan, Qi. "Regulation of retinal endothelial cells and pericytes by VEGF, TGF-beta1, and SPARC /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/5686.

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34

Kong, Pui-ching Christie. "Nucleocytoplasmic shuttling of Smad7 that plays paradoxical roles in hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B44226883.

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35

林詩敏 and Sze-man Joyce Lam. "Expression of transforming growth factors (TGF-alpha and TGF-beta 1) on postmortem skin wounds." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011400.

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36

Liu, Chi 1963. "Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63768.

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37

Wang, Qian-Shu. "Alterations in Transforming Growth Factors and G1 Cyclins in N- Nitrosomethylbenzylamine-Induced Rat Esophageal Tumorigenesis /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487935125881887.

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38

Ekrikpo, Udeme Ekpenyong. "Chronic kidney disease in HIV populations: prevalence, risk factors and role of transforming growth factor beta (TGF-߀1) polymorphisms." Doctoral thesis, Faculty of Health Sciences, 2019. https://hdl.handle.net/11427/31740.

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Background and purpose: With the advent of antiretroviral therapy, HIV-infected individuals now live longer and are at increased risk of chronic kidney disease (CKD). Also, recent studies indicate a genetic predisposition to CKD in the African HIV population. This work investigated the prevalence of CKD (and its correlates) in the global and local HIV population and proceeded to investigate the diagnostic utility of urinary transforming growth factor-beta-1 (TGF-β1) for CKD in the HIV population and determine the association between polymorphisms of TGF-β1 gene and prevalent CKD. Methods: A me
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39

Lee, Yin-yin Candice. "The role of thrombospondin-1 in the synthesis and activation of TGF-[beta]1 in human proximal tubular epithelial cells under elevated glucose concentrations /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31596010.

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40

Rohe, Benjamin G. "Regulation of 1,25D(3)-MARRS expression by TGFB1 in a rat intestinal epithelial cell line." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 4.38 Mb., 108 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1435850.

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41

Mace, Peter, and n/a. "Biochemistry of ovine bone and morphogenetic proteins and receptors." University of Otago. Department of Biochemistry, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070508.133410.

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The transforming growth factor (TGF)-β superfamily mediates a wide range of differentiation and developmental processes across many genera. GDF9 and BMP15 are expressed exclusively in the mammalian ovary and are the only TGF-β ligands that lack the conserved cysteine residue used for dimerisation. As a platform for studying the interactions between GDF9 and BMP15 and their receptors, BMPRII and BMPRIb, a variety of strategies were attempted to produce soluble and active proteins from recombinant systems. Both ligands and receptors showed a tendency to form insoluble aggregates when expressed i
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42

Guo, Hong. "Molecular therapy for peritoneal fibrosis targeting the TGF-b/Smad signaling pathway /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557509.

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43

Guo, Hong, and 郭紅. "Molecular therapy for peritoneal fibrosis: targeting the TGF-{221}/Smad signaling pathway." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557509.

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44

Lee, B. C. Bob, and 李卜駿. "Probing the molecular mechanisms of how polymorphisms in Cerberus-likeresult in low bone mineral density." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793771.

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45

Herbert, Brittney-Shea. "Mechanisms of RRR-[alpha]-tocopheryl succinate- and N-(4-hydroxyphenyl)retinamide-induced apoptosis of human HL-60 myelocytic leukemia and MDA-MB-435 breast cancer cells : a role for TGF-[beta] and C-JUN /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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46

Allende, Marie Alexandra. "Blood vessel growth in primate retinal development relationship of retinal maturation with choriocapillaris growth and a role for TGF-ß in the retina /." Connect to full text, 2008. http://hdl.handle.net/2123/4145.

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Thesis (Ph. D.)--University of Sydney, 2008.<br>Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Clinical Ophthalmology and Eye Health, Faculty of Medicine. Title from title screen (viewed Apr. 8, 2009) Includes bibliography. Also available in print form.
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47

Laurens, Ilze. "Development of a new extraction method for platelet-rich plasma and partial purification of platelet-derived growth factor and transforming growth factor beta." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40717.

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Platelet-rich plasma (PRP) is the cell free plasma, which has an enriched concentration of platelets and clotting factors with the ability to enhance the natural healing process. PRP is often used by physicians in an office setting to accelerate the healing of a variety of sports related injuries, chronic wounds and enhance skin rejuvenation. PRP mimics the wound healing cascade by enhancing the recruitment, proliferation and differentiation of cells involved in tissue regeneration. Although PRP is used to enhance healing, the efficacy thereof is debated as no clear-cut set of parameters
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48

陳嘉威 and Ka-wai Patrick Chan. "Transforming growth factor-{221}1 induces cell invasiveness via the downregulation of junctional adhesion molecule-A." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47151602.

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49

Hester, Mark Edward. "Utilization of gene knockout approaches in the mouse to elucidate additional functions of smad proteins during mammalian development." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1118656704.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 137 p.; also includes graphics. Includes bibliographical references (p. 122-137). Available online via OhioLINK's ETD Center
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50

Popescu, Olivia. "Characterization of Dante, a novel member of the DANCerberus family TGF-[beta] inhibitors." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80856.

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TGFbeta signaling peptides have been shown to play increasingly diverse roles in metazoan development and tissue homeostasis. Negative regulation of TGFbeta ligands such as Nodal can be achieved by physical interactions with inhibitory molecules. Dante is a recently identified putative member of DAN/Cerberus family of TGFbeta inhibitors. Previously shown to be unilaterally expressed on the right side of the mouse node, Dante has been suggested to play a role in Left-Right axis formation possibly by inhibition of Nodal molecules. The aim of this study was to further characterize Dante an
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