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Dissertations / Theses on the topic 'Transferrin'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Fouquet, Guillemette. "Régulation de l’érythropoïèse : rôle des récepteurs à la transferrine et d’un phytoestrogène." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS293.

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L’érythropoïèse est un processus extrêmement prolifératif, et qui doit donc être très étroitement régulé. L’érythropoïétine (EPO) est l’un des facteurs absolument nécessaires à l’érythropoïèse. Cependant, dans la moelle osseuse, la quantité d'EPO circulante est sous-optimale et la capacité des érythroblastes à survivre dépend donc de leur sensibilité à l'EPO. Les facteurs modulant la réponse à l'EPO au cours de l'érythropoïèse sont encore largement inconnus.Nous avons donc voulu explorer plusieurs facteurs pouvant potentiellement être impliqués dans la régulation de l’érythropoïèse et plus pré

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2

Sharma, Nita Devi. "Molecular definition of the interaction of transferrin with the meningococcal and human transferrin receptor." Thesis, Birkbeck (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338641.

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3

Stokes, Russell Hayden. "Meningococcal transferrin binding proteins A and B form a functional human serum transferrin receptor." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313503.

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4

Booyjzsen, Claire. "Fibril formation by human transferrin." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/51615/.

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There is a well-established connection between anomalous protein aggregates and disease, exemplified by the amyloidoses. Many neurological disorders such as Al heimer’s and Parkinson’s disease also show increased concentrations of iron deposits along with protein fibres. The increased metal concentrations observed in these instances have yet to be fully understood or explained. The research in this thesis is concerned with the aggregation of the protein transferrin, especially on surfaces. Human serum transferrin is an ~80 kDa iron-transporting glycoprotein found at 35 μM in the blood. It is a

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5

Baptista, Rafaela Speranza [UNESP]. "Proteinograma sérico de cordeiros nascidos a termo ou prematuros." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/146742.

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Baptista, Rafaela Speranza. "Proteinograma sérico de cordeiros nascidos a termo ou prematuros /." Araçatuba, 2016. http://hdl.handle.net/11449/146742.

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Orientador: Luiz Claudio Nogueira Mendes<br>Coorientadora: Fernanda Bovino<br>Banca:Francisco Leydson Formiga Feitosa<br>Banca:Marcio Carvalho da Costa<br>Resumo: Ao final da gestação o neonato deve estar preparado, por meio de modificações funcionais e estruturais de órgãos e sistemas para dar início à vida extra-uterina. Os animais prematuros nascem antes deste processo estar completo, apresentando falhas na maturação. O objetivo deste estudo foi tentar identificar por meio da técnica de eletroforese em gel de poliacrilamida em dodecil sulfato de sódio (SDS-PAGE) proteínas de fase aguda, den

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7

Trimble, Esther R. "Carbohydrate-deficient transferrin and alcohol abuse." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388195.

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8

Kaur, Ishwinder. "Nuclear translocation and transferrin-transferrin receptor interaction of IPSE/[alpha}-1, a secretory glycoprotein from Schistosoma mansoni." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508222.

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Helminthic parasites have evolved with immune modulating machinery to manipulate their host's immune response and thus survive unscathed for years and in some cases even decades. However, the underlying molecular mechanisms governing the host-parasite relationship are still largely unknown. Therefore detailed investigation and evaluation of parasitic molecules is desirable. One such molecule worthy of attention is IPSE/a-1 (lnterleukin-4 inducing principle from schistosome eggs). IPSE/a-1 is a secretory glycoprotein produced exclusively by the egg stage of Schistosoma mansoni, which activates

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9

Bergström, Jonas P. "Human serum transferrin glycosylation pattern : population differencies, analytical methodology and application as biomarker for testing of alcohol abuse and CDG /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-432-7/.

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10

Houldershaw, David. "The electrostatics of iron binding to transferrin." Thesis, Birkbeck (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244463.

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11

Bunyan, Kerry Emma. "Chemical and biological studies of manganese transferrin." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/15569.

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This thesis is concerned with the loading of transferrin with manganese and some of its chemical and biological properties. Manganese is bound to transferrin as Mn(III) with a characteristic ligand (Tyr) to metal (Mn(III) charge-transfer band at a wavelength of 430 nm. Caeruloplasmin is shown to enhance the uptake of manganese from MnC1<sub>2</sub> by apo-hTf. However binding is often incomplete and slow. A novel method of loading hTf with Mn using KMnO<sub>4</sub> is reported. This method leads to rapid uptake and inductively coupled plasma atomic emission spectroscopy (ICP-AES) determinants

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12

Price, Gregory A. "Immunogenicity of the Gonococcal Transferrin Binding Proteins." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd_retro/76.

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The gonococcal transferrin binding proteins (Tbps) are two surface-exposed outer membrane proteins, TbpA and TbpB, which together function to remove and internalized iron from human transferrin. Iron is an essential nutrient to the gonococcus, without which it cannot survive. The Tbps have been established as virulence factors, demonstrating their importance in establishing infection. Both TbpA and TbpB are well conserved among gonococcal isolates, and have been considered potential vaccine targets. Vaccine studies with the closely related species Neisseria meningitidis, have demonstrated

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13

Hodgkins, Paul S. "Reduced metal transferrin binding in neurological diseases." Thesis, Aston University, 1992. http://publications.aston.ac.uk/12605/.

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By employing G75 gel-filtration chromotography, it has been demonstrated that human plasma gallium speciation (and by implication, Al speciation) is bimodal. Normally, gallium was predominantly bound to a high molecular weight fraction which was presumably transferrin. Literature reviews and experimental work throughout this thesis provided evidence to support this idea. An aluminium-transferrin species was assumed to be relatively non-toxic and a protective function for this complex has been suggested. A second, low molecular weight species of gallium was observed and its identity has been su

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14

Ulin, Desirée. "Metodverifiering av ny upparbetningsmetod för kolhydratfattigt transferrin." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-85498.

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Transferrin är ett protein som har uppgiften att transportera järn i kroppen. Transferrin är ett glykoprotein med två kolhydratkedjor med två, tre förgreningar med terminala sialinsyror. Antalet sialinsyror ger proteinet olika isoformer och benämns därefter, så som tetrasialotransferrin som har fyra terminala sialinsyror och är den vanligaste förekommande isoformen. Disialotransferrin används som en biokemisk markör för att identifiera individer som har en hög alkoholkonsumtion under en längre period. Disialotransferrin ökar i koncentrationen vid hög alkoholkonsumtion under minst 14 dagar. Den

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15

Lok, Chun-nam, and 陸振南. "Regulation of transferrin receptor expression in human leukemic HL-60 cells: gene expression and cellular signaling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31235141.

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16

Lok, Chun-nam. "Regulation of transferrin receptor expression in human leukemic HL-60 cells : gene expression and cellular signaling /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17310659.

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17

Giannetti, Anthony Michael Rees Douglas C. "Biochemical, biophysical, and cellular investigations of the interactions of transferrin receptor with transferrin and the hereditary hemochromatosis protein, HFE /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-05262004-173612.

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18

CABRAL, FILHO Paulo Euzébio. "Desenvolvimento de sondas multimodais baseadas em pontos quânticos para aplicações biomédicas." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18443.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-03-28T13:13:15Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Cabral Filho, PE Tese - PPGCB.pdf: 40667296 bytes, checksum: 0fe805957d5ab95d53bed853da61deb5 (MD5)<br>Made available in DSpace on 2017-03-28T13:13:15Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Cabral Filho, PE Tese - PPGCB.pdf: 40667296 bytes, checksum: 0fe805957d5ab95d53bed853da61deb5 (MD5) Previous issue date: 2016-07-15<br>CAPES<br>Os pon

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19

Adam, Mohammed A. "Fate of the transferrin receptor during in vitro maturation of sheep reticulocytes and post-translational modifications of the transferrin receptor." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70354.

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The transferrin receptor is a membrane protein which is involved in the binding and endocytosis of transferrin, the main Fe$ sp{3+}$ carrying protein. The receptor and transferrin function to provide cells with iron, an essential nutrient. As red cells mature and lose their ability to make hemoglobin, they also lose their capacity to bind transferrin and take up iron. The transferrin receptor in sheep reticulocytes has been shown to undergo externalization in vesicular form during maturation of sheep reticulocytes in vitro. Microscopic studies show that the receptor is internalized into endoso

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20

Sun, Xuesong. "Iron metabolism mediated by MtsA, transferrin and desferrioxamine." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37552995.

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21

Zuccola, Harmon Jay. "The crystal structure of monoferric human serum transferrin." Diss., Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/26304.

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22

Sun, Xuesong, and 孫雪松. "Iron metabolism mediated by MtsA, transferrin and desferrioxamine." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38722446.

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23

Boulton, Ian Charles. "In vitro characterisation of the meningococcal transferrin receptor." Thesis, Birkbeck (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266085.

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24

Oakhill, Jonathan Stuart. "Structural studies of meningococcal transferrin-binding protein A." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271430.

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25

Okyere-Boakye, Ivan W. "Studies on genetic variants of human plasma transferrin." Thesis, Queen Mary, University of London, 1997. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1639.

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The work presented in this thesis is concerned with the characterisation of human plasma transferrins showing abnormal electrophoretic mobilities on polyacrylamide gels. The work is divided into three studies: (i) a study of transferrin variants detected by nondenaturing polyacrylamide gel electrophoresis; (ii) a study of the plasma concentrations of individuals showing transferrin phenotypes associated with the three most common Tf C alleles, Tf Cl, Tf C2 and Tf C3; and (iii) a study of a reported nondegenerate nucleotide difference in the sequence of the cloned human transferrin gene. In the

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26

Kim, Jonghan. "Pharmacokinetics and pharmacodynamics of protein turnover and production in vivo." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1100554543.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xxi, 203 p.; also includes graphics. Includes bibliographical references (p. 191-203).

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27

Vieillevoye, Maud. "Role and expression of transferrin receptor 2 in erythropoiesis." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05S020.

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L’érythropoïèse est le processus de différentiation d’un progéniteur érythroïde multipotent en globules rouges. La différentiation érythroïde est essentiellement contrôlée par le récepteur à l’érythropoïétine (EPOR). Nous avons montré que le récepteur à la transferrine de type 2 (TFR2) est un membre important du complexe formé par l’EPOR. Le TFR2 présente, comme l’EPOR une expression restreinte qui dépend du type cellulaire. Ainsi son expression n’a pu être détectée que dans le foie, l’érythron et l’intestin grêle. Le rôle du TFR2 a été exploré dans les hépatocytes et il a été montré qu’il jou

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28

Pulido-Cejudo, Gabriel. "Chemical and biological properties of iron-pyruvate-transferrin complexes." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74529.

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The preparation of a novel complex, ferric bromopyruvate, is described. In solutions from which most of the carbonate has been removed, ferric bromopyruvate can be used both as an iron and pyruvate source for the full iron saturation of apotransferrin. Using ferric bromopyruvate as an iron donor, iron incorporation into human apotransferrin is biphasic; the N-terminal domain is saturated three times faster than its homologous C-terminal iron binding site. Following the reaction of apotransferrin with ferric bromopyruvate, 4 moles of pyruvate per mole of transferrin are covalently bound. Based

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29

Yoon, Hye-Sun Melissa 1977. "Molecular cloning and characterization of mouse transferrin receptor 2." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33861.

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Iron (Fe) plays an essential role in numerous metabolic processes. The transferrin receptor (TfR) is a cell membrane-associated protein that serves as a gatekeeper in regulating cellular uptake of Fe from transferrin (Tf) by TfR-mediated endocytosis. TfRs are expressed ubiquitously, but their highest levels of expression are on immature erythroid cells (which are the most avid consumers of Fe in the organism) and on rapidly dividing cells, both normal and malignant. In proliferating non-erythroid cells TfR expression is feedback inhibited by Fe through the interaction of specific binding prote

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30

Modun, Belinda J. "Identification and characterisation of transferrin-binding proteins in staphylococci." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283401.

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31

Hsuan, J. J. "Study of the oxidation of transferrin by periodate anions." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372042.

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32

Ali, Stuart Alvaro. "Transferrin trojan horses : a novel approach for drug delivery?" Thesis, Brunel University, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285047.

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33

Araujo, Felipe Saldanha de. "Avaliação fenotípica dos linfócitos T em um modelo animal de deficiência de ferro." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-17052007-094115/.

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O ferro é um elemento chave em muitos processos metabólicos, como transporte de oxigênio, síntese de hormônios esteróides, respiração celular, transporte de elétrons, síntese de DNA, proliferação e diferenciação celular e regulação gênica. A deficiência de ferro é a desordem nutricional mais comum afetando aproximadamente um terço da população mundial. Pequenos déficits no compartimento funcional de ferro têm sérias conseqüências sobre o sistema imune, principalmente na imunidade mediada por células. A abordagem dos pais ou responsáveis, as exigências éticas e a aderência de crianças da mesma

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34

Hudson, David M. "Studies on the role of hephaestin and transferrin in iron transport." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1491.

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Iron homeostasis is essential for maintaining the physiological requirement for iron while preventing iron overload. Multicopper ferroxidases regulate the oxidation of Fe(II) to Fe(III), circumventing the generation of harmful hydroxyl-free radicals. Ceruloplasmin is the major multicopper ferroxidase in blood; however, hephaestin, a membrane-bound ceruloplasmin homolog, has been implicated in the export of iron from duodenal enterocytes into blood. These ferroxidases supply transferrin, the iron-carrier protein in plasma, with Fe(III). Transferrin circulates through blood and delivers iron

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35

Lokey, Laurie Kathleen. "The expression of human serum transferrin in E. Coli (Part I) : Part II: The cloning of the reverse transcriptase of human immunodeficiency virus I." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/27380.

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36

Morris, Patricia Ann. "EXAFS of non-heme iron containing proteins." Diss., Georgia Institute of Technology, 1986. http://hdl.handle.net/1853/27402.

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37

Steinlein, Lauren Marie. "Recombinant expression of human serum transferrin in escherichia coli and pichia pastoris." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/30947.

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38

Zablith, Nadine. "The association between amniotic fluid albumin, prealbumin or transferrin and the fetal growth /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98526.

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The study objectives were to measure the concentrations of albumin, prealbumin and transferrin in amniotic fluid (AF), and to establish if these concentrations were associated with infant birth weight (BW). At St Mary's Hospital (Montreal, Quebec), 294 AF samples were collected from mothers undergoing routine amniocentesis (12-19 weeks gestation). Exclusion criteria included subjects having gestational diabetes, multiple births or fetal genetic abnormalities. AF samples were analyzed by capillary electrophoresis (CE) at 190 nm. Analysis of variance and multiple linear regressions were performe

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39

Jordan, Peter A. "Physico-chemical studies of aluminium biochemistry." Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294654.

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40

Chan, Yuen-yee Roxanne. "Studies on receptor-mediated uptake of transferrin and iron acquisition by rabbit reticulocytes and a rat hepatoma cell line /." Hong Kong : University of Hong Kong, 1986. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12325193.

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41

Koehl, Philipp. "Untersuchung von Carbohydrat-Deficient Transferrin (CDT) als Parameter für Alkoholkonsum /." Regensburg, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254401.

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42

Wiescher, Christina. "Mini-Isoelektrofokussierung von Serum-Transferrin bei Patienten mit CDG-Syndrom." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-12684.

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43

Lazarus, Alan H. "Involvement of transferrin receptors in human natural killer cell specificity." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75860.

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Natural Killer (NK) cells are able to recognize and lyse tumor cells without prior immunization or sensitization. The initial events leading to target cell lysis by NK cells involves a poorly defined recognition and binding phase. It has been hypothesized however that human NK cells may recognize transferrin receptors as target structures on tumor cells.<br>To determine the possible involvement of transferrin receptors in human NK cell specificity, a correlation study between transferrin receptor expression and competitive activity for NK cell mediated lysis was undertaken. We have determined

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44

Sandrini, Sara M. "Interaction of Escherichia coli with catecholamine hormones, transferrin and lactoferrin." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/9946.

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The correlation between stress and increased susceptibility to infectious disease has been widely established. A direct consequence of stress, whether physical or mental, is the release of catecholamine stress hormones (adrenaline and noradrenaline), which as well as reducing immune function, have recently been shown to directly enhance the growth of a variety of Gram positive and Gram negative bacteria. The mechanism of catecholamine-induced growth stimulation involved catecholamines facilitating iron removal from the high affinity mammalian iron binding proteins transferrin and lactoferrin.

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45

Hutchinson, Carol. "Iron absorption and serum non-transferrin bound iron in humans." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429314.

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46

Gordon, Harriet Mary. "Serum carbohydrate-deficient transferrin as a marker of alcohol abuse." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396017.

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47

Chang, Jiang. "Transferrin-PLGA nanoparticles applications to brain, glioma and trypanosoma targeting." Lille 2, 2009. http://www.theses.fr/2009LIL2S015.

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L'utilisation de nanoparticules pour la vectorisation de médicaments connaît un intérêt croissant en vue de diminuer les doses de médicaments administrés et de réduire leur toxicité. Dans le cadre de ce travail de thèse nous avons préparé des poly (D, L-lactide-co-glycolide) (PLGA) nanoparticules (NPs) biodégradables de taille de 80-nm en vue de les utiliser pour cibler les cellules surexprimant le récepteur de la transferrine (Tf-R). Lors de la préparation de ces nanoparticules nous avons montré que nous pouvions éviter l'utilisation de surfactants utilisés pour éviter l'agrégation des nanopa

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48

DeRocco, Amanda Jean. "Molecular Analysis of Transferrin Binding Protein B in Neisseria Gonorrhoeae." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/52.

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The transferrin iron acquisition system of Neisseria consists of two dissimilar proteins, transferrin binding protein A and B (TbpA and TbpB). TbpA and TbpB both specifically and independently bind human transferrin (Tf). TbpA is a TonB-dependent transporter, expression of which is necessary for Tf iron acquisition. In contrast, the lipoprotein TbpB is not necessary for iron internalization; however it makes this process more efficient. The role of TbpB in the transferrin iron acquisition system has not been completely elucidated. It has been suggested that TbpB is entirely surface expose

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49

Winsper, Sarah J. "Metal binding to transferrin and immune reactions in Parkinson's disease." Thesis, Aston University, 1995. http://publications.aston.ac.uk/11045/.

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The binding of iron (59Fe) and gallium (67Ga) to the plasma protein transferrin (Tf) was investigated by G75 gel filtration chromatography in control patients and treated and untreated patients with Parkinson's disease (PD). Fe-Tf binding was 100% in all controls and PD patients suggesting that a defect in Fe-Tf binding was not involved in the aetiology of PD. Ga-Tf binding was significantly reduced in both untreated and treated PD patients compared to controls. In addition, treated PD patients had significantly higher Ga-Tf binding than untreated patients. A reduction in metal binding to Tf c

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50

Ghebreamlak, Weyni. "Identification of Trypsin Digested Transferrin using HPLC and MALDI-MS." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-266157.

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In this project, separation of trypsin digested transferrin (Tf) has been studied, using a RP HPLC- UV system equipped with a C18 column. 0.1% TFA/MQ-water and 90% MeOH were used as mobile phase A and mobile phase B, respectively. For economic reasons, the protein cytochrome c (cyt-C) was used to optimize the digestion procedure and LC system, before analysis of Tf. Four digestion methods were applied for analyzing cyt-C and Tf. The first method was digestion with no denaturing, reducing or alkylating agent. The other digestion methods used urea or heating as a denaturing agent, and lastly dit

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