Academic literature on the topic 'Transcriptional Regulation'

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Journal articles on the topic "Transcriptional Regulation"

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Cornut, Maxence, Emilie Bourdonnay, and Thomas Henry. "Transcriptional Regulation of Inflammasomes." International Journal of Molecular Sciences 21, no. 21 (2020): 8087. http://dx.doi.org/10.3390/ijms21218087.

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Inflammasomes are multimolecular complexes with potent inflammatory activity. As such, their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this review, we present the transcriptional regulation of inflammasome genes from sensors (e.g., NLRP3) to substrates (e.g., IL-1β). Lineage-determining transcription factors shape inflammasome responses in different cell types with profound consequences on the responsiveness to inflammasome-activating stimuli. Pro-inflammatory signals (sterile or microbial) have a key transcriptional impact on inflammasome genes,
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Lee, Pauline, Truksa Jaroslav, Hongfan Peng, and Ernest Beutler. "Transcriptional Regulation of Hepcidin by Iron." Blood 110, no. 11 (2007): 2664. http://dx.doi.org/10.1182/blood.v110.11.2664.2664.

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Abstract Transcriptional regulation by iron in mammalian systems is poorly understood. Hepcidin, a 25 amino acid peptide that plays a central role in iron homeostasis, is transcriptionally regulated by iron. A region of the murine hepcidin promoter 1.6 to 1.8 kb upstream from the start of translation was recently identified to be important in transcriptional regulation by iron (Truksa J, et al. The distal location of the iron responsive region of the hepcidin promoter. Blood DOI 10.1182/blood-2007-05-091108, 2007). In order to identify transcription factors that might be important in regulatio
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Wilson, Nicola K., Fernando J. Calero-Nieto, Rita Ferreira, and Berthold Göttgens. "Transcriptional regulation of haematopoietic transcription factors." Stem Cell Research & Therapy 2, no. 1 (2011): 6. http://dx.doi.org/10.1186/scrt47.

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Dutta, Chaitali, Prasanta K. Patel, Adam Rosebrock, Anna Oliva, Janet Leatherwood, and Nicholas Rhind. "The DNA Replication Checkpoint Directly Regulates MBF-Dependent G1/S Transcription." Molecular and Cellular Biology 28, no. 19 (2008): 5977–85. http://dx.doi.org/10.1128/mcb.00596-08.

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ABSTRACT The DNA replication checkpoint transcriptionally upregulates genes that allow cells to adapt to and survive replication stress. Our results show that, in the fission yeast Schizosaccharomyces pombe, the replication checkpoint regulates the entire G1/S transcriptional program by directly regulating MBF, the G1/S transcription factor. Instead of initiating a checkpoint-specific transcriptional program, the replication checkpoint targets MBF to maintain the normal G1/S transcriptional program during replication stress. We propose a mechanism for this regulation, based on in vitro phospho
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Shimizu, Kiminori, Julie K. Hicks, Tzu-Pi Huang, and Nancy P. Keller. "Pka, Ras and RGS Protein Interactions Regulate Activity of AflR, a Zn(II)2Cys6 Transcription Factor in Aspergillus nidulans." Genetics 165, no. 3 (2003): 1095–104. http://dx.doi.org/10.1093/genetics/165.3.1095.

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Abstract Sterigmatocystin (ST) is a carcinogenic polyketide produced by several filamentous fungi including Aspergillus nidulans. Expression of ST biosynthetic genes (stc genes) requires activity of a Zn(II)2Cys6 transcription factor, AflR. aflR is transcriptionally and post-transcriptionally regulated by a G-protein/cAMP/protein kinase A (PkaA) signaling pathway involving FlbA, an RGS (regulator of G-protein signaling) protein. Prior genetic data showed that FlbA transcriptional regulation of aflR was PkaA dependent. Here we show that mutation of three PkaA phosphorylation sites in AflR allow
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Hahn, Steven. "Transcriptional regulation." EMBO reports 9, no. 7 (2008): 612–16. http://dx.doi.org/10.1038/embor.2008.99.

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Helntz, Nathaniel. "Transcriptional regulation." Trends in Biochemical Sciences 16 (January 1991): 393. http://dx.doi.org/10.1016/0968-0004(91)90161-n.

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Matthews, J. L., M. G. Zwick, and M. R. Paule. "Coordinate regulation of ribosomal component synthesis in Acanthamoeba castellanii: 5S RNA transcription is down regulated during encystment by alteration of TFIIIA activity." Molecular and Cellular Biology 15, no. 6 (1995): 3327–35. http://dx.doi.org/10.1128/mcb.15.6.3327.

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Transcription of large rRNA precursor and 5S RNA were examined during encystment of Acanthamoeba castellanii. Both transcription units are down regulated almost coordinately during this process, though 5S RNA transcription is not as completely shut down as rRNA transcription. The protein components necessary for transcription of 5S RNA and tRNA were determined, and fractions containing transcription factors comparable to TFIIIA, TFIIIB, and TFIIIC, as well as RNA polymerase III and a 3'-end processing activity, were identified. Regulation of 5S RNA transcription could be recapitulated in vitro
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Desvergne, Béatrice, Liliane Michalik, and Walter Wahli. "Transcriptional Regulation of Metabolism." Physiological Reviews 86, no. 2 (2006): 465–514. http://dx.doi.org/10.1152/physrev.00025.2005.

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Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made towards elucidating the mechanisms controlling the major regulatory pathways are now being rewarded. At the molecular level, the crucial role of transcription factors is particularly well-illustrated by the link between alterations of their functions and the occurrence of major metabolic diseases. In addition, the possibility of manipulating the ligand-dependent activity of some of these transcription factors makes them attractive as therapeutic targets. The aim of this review is to summarize recent knowle
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Geng, Yanbiao, Peter Laslo, Kevin Barton, and Chyung-Ru Wang. "Transcriptional Regulation ofCD1D1by Ets Family Transcription Factors." Journal of Immunology 175, no. 2 (2005): 1022–29. http://dx.doi.org/10.4049/jimmunol.175.2.1022.

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Dissertations / Theses on the topic "Transcriptional Regulation"

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Adegoke, Oluwajoba Oluwapelumi. "Transcriptional and post-transcriptional regulation in testicular toxicity." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/31979.

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The control of gene expression occurs at multiple levels one of which is controlled by epigenetic regulation. In this work, it was hypothesised that changes in DNA methylation (transcriptional level) and miRNA expression (post-transcriptional level) might be involved in the mechanism of compound-induced testicular toxicity. mRNA and miRNA analysis of mouse testis was performed following exposure to dibutyl phthalate, 17β-estradiol and doxorubicin. Pathway analysis of transcriptional changes revealed all three chemicals interfered with the steroidogenic pathway, with further modulation of oxida
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Dennis, Jonathan Hancock. "Transcriptional regulation by Brn 3 POU domain containing transcription factors." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249684.

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Koutsoulidou, Andrie. "Investigation of transcriptional and post-transcriptional regulation of myogenesis." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559081.

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Skeletal myogenesis IS a complicated and tightly regulated process, at both transcriptional and post-transcriptional levels. Muscle cells isolated from different stages of the human foetal development displayed increased capacity to differentiate in vitro at late stages of the development. Twist is an early developmental transcription factor shown to inhibit muscle differentiation in mice. Endogenous human TWIST (H-TWIST) protein levels were found to be inversely proportional to the state of foetal muscle development and the capacity of isolated myoblasts to differentiate in vitro. Investigati
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Asif, Hafiz Muhammad Shahzad. "Inference dynamics in transcriptional regulation." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6238.

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Computational systems biology is an emerging area of research that focuses on understanding the holistic view of complex biological systems with the help of statistical, mathematical and computational techniques. The regulation of gene expression in gene regulatory network is a fundamental task performed by all known forms of life. In this subsystem, modelling the behaviour of the components and their interactions can provide useful biological insights. Statistical approaches for understanding biological phenomena such as gene regulation are proving to be useful for understanding the biologica
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Kang, Martin Hubert. "Post-transcriptional regulation of ABCA1." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43655.

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Epidemiological studies consistently demonstrate an inverse relationship between HDL levels and cardiovascular disease (CVD), independent of LDL and triglyceride levels. Due to the crucial role ABCA1 plays in HDL biogenesis, increasing ABCA1 expression is considered an attractive strategy to increase plasma HDL levels. In this thesis we attempt to identify novel post-transcriptional and post-translational mechanisms that regulate ABCA1 expression and/or function. Prior to translation, ABCA1 protein expression is regulated by non-coding RNA molecules known as microRNAs which bind and inhibit tr
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Glasspool, Rosalind M. "The transcriptional regulation of telomerase." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398635.

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Weintraub, Abraham S. (Abraham Selby). "Transcriptional regulation and genome structure." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117886.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.<br>Cataloged from PDF version of thesis. Page 162 blink.<br>Includes bibliographical references.<br>The regulation of gene expression is fundamental to the control of cell identity, development and disease. The control of gene transcription is a major point in the regulation of gene expression. Transcription is regulated by the binding of transcription factors to DNA regulatory elements known as enhancers and promoters. This leads to the formation of a DNA loop connecting the enhancer and the promoter resulting
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McCormick, Margaret M. (Margaret Mary). "Transcriptional regulation in Corynebacterium glutamicum." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/11197.

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Hochhauser, Daniel. "Transcriptional regulation of topoisomerase II." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333178.

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Reid, John Edward. "Probabilistic models of transcriptional regulation." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648864.

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Books on the topic "Transcriptional Regulation"

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L, McKnight Steven, and Yamamoto Keith R, eds. Transcriptional regulation. Cold Spring Harbor Laboratory Press, 1992.

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Vancura, Ales, ed. Transcriptional Regulation. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-61779-376-9.

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MUKHTAR, SHAHID, ed. Modeling Transcriptional Regulation. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1534-8.

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Dassi, Erik, ed. Post-Transcriptional Gene Regulation. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1851-6.

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Wilusz, Jeffrey, ed. Post-Transcriptional Gene Regulation. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-033-1.

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Dassi, Erik, ed. Post-Transcriptional Gene Regulation. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3067-8.

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Jeffrey, Wilusz, ed. Post-transcriptional gene regulation. Humana Press, 2008.

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Courey, Albert J. Mechanisms in transcriptional regulation. Blackwell Pub., 2008.

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Wajapeyee, Narendra, and Romi Gupta, eds. Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6518-2.

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NATO/CEC, Advanced Research Workshop on "Post-Transcriptional Control of Gene Expression" (1990 Goslar Germany). Post-transcriptional control of gene expression. Springer-Verlag, 1990.

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Book chapters on the topic "Transcriptional Regulation"

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Scotto, Kathleen W., and Tan A. Ince. "Transcriptional Regulation." In Basic Science of Cancer. Current Medicine Group, 2000. http://dx.doi.org/10.1007/978-1-4684-8437-3_6.

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Huang, Yufei. "Transcriptional Regulation." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_815.

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Snyder, Lori A. S. "Transcriptional Regulation." In Bacterial Genetics and Genomics, 2nd ed. Garland Science, 2024. http://dx.doi.org/10.1201/9781003380436-8.

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Tuckermann, Jan, Peter Herrlich, and Giorgio Caratti. "Transcriptional Regulation." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-21573-6_255-1.

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Tuckermann, Jan, Peter Herrlich, and Giorgio Caratti. "Transcriptional Regulation." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_255.

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Provero, Paolo. "Transcriptional Regulation." In Principles of Computational Genomics. Chapman and Hall/CRC, 2025. https://doi.org/10.1201/9781003449928-5.

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Moyano, Tomás C., Rodrigo A. Gutiérrez, and José M. Alvarez. "Genomic Footprinting Analyses from DNase-seq Data to Construct Gene Regulatory Networks." In Modeling Transcriptional Regulation. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1534-8_3.

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Aljedaani, Fatimah, Naganand Rayapuram, and Ikram Blilou. "A Semi-In Vivo Transcriptional Assay to Dissect Plant Defense Regulatory Modules." In Modeling Transcriptional Regulation. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1534-8_13.

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Wang, Xingwei, Yufeng Xu, Mian Zhou, and Wei Wang. "Assessing Global Circadian Rhythm Through Single-Time-Point Transcriptomic Analysis." In Modeling Transcriptional Regulation. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1534-8_14.

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AbuQamar, Synan F., Khaled A. El-Tarabily, and Arjun Sham. "Co-expression Networks in Predicting Transcriptional Gene Regulation." In Modeling Transcriptional Regulation. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1534-8_1.

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Conference papers on the topic "Transcriptional Regulation"

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Pinard, Desre. "Eucalyptus grandis organellar gene transcriptional and post-transcriptional regulation in developing xylem." In ASPB PLANT BIOLOGY 2020. ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1053020.

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Ogul, Hasan, and Giray S. Ozcan. "A framework for integrative analysis of transcriptional and post-transcriptional gene regulation." In 2013 7th International Conference on Application of Information and Communication Technologies (AICT). IEEE, 2013. http://dx.doi.org/10.1109/icaict.2013.6722723.

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Canteiro, Beatriz, Maria Mendes, Filipa Jacques, et al. "Effects of Quercetin in transcriptional and post-transcriptional regulation of fetal hemoglobin." In 2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG). IEEE, 2023. http://dx.doi.org/10.1109/enbeng58165.2023.10175363.

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"Reconstruction of mathematical frame models of bacterial transcription regulation based on transcriptional regulatory networks." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-120.

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Krivosheev, Ivan, Lei Du, and Xia Li. "Transcriptional Regulation of Human Gene Coexpression Network." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5163698.

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Giaretta, Alberto. "Noise in transcriptional, splicing and translational regulation." In 2020 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). IEEE, 2020. http://dx.doi.org/10.1109/cibcb48159.2020.9277724.

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Bolt, Tayah. "Transcriptional Regulation of the Plant Shikimate Pathway." In ASPB PLANT BIOLOGY 2020. ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1052617.

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"STRUCTURAL MOTIF ENUMERATION IN TRANSCRIPTIONAL REGULATION NETWORKS." In International Conference on Bioinformatics. SciTePress - Science and and Technology Publications, 2010. http://dx.doi.org/10.5220/0002760001870192.

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Yaglova, Nataliya Valentinovna, Sergey Stanislavovich Obernikhin, Valentin Vasilyevich Yaglov, and Svetlana Vladimirovna Nazimova. "TRANSCRIPTIONAL REGULATION OF ADRENAL CORTEX POSTNATAL DEVELOPMENT AND FUNCTION." In International conference New technologies in medicine, biology, pharmacology and ecology (NT +M&Ec ' 2020). Institute of information technology, 2020. http://dx.doi.org/10.47501/978-5-6044060-0-7.08.

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Expression of transcriptional factor Oct4 and Shh in rat adrenal cortex during postnatal development and the role for this factors in functional activity of adrenal cortex and tissue homeostasis was determined.
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Rao, Arvind, Alfred Hero, David States, and James Engel. "Manifold embedding for understanding mechanisms of transcriptional regulation." In 2006 IEEE International Workshop on Genomic Signal Processing and Statistics. IEEE, 2006. http://dx.doi.org/10.1109/gensips.2006.353127.

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Reports on the topic "Transcriptional Regulation"

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Thakur, Sanjay, and Carlo M. Croce. Transcriptional Regulation of BRCA1. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada398226.

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Thakur, Sanjay, and Carlo Croce. Transcriptional Regulation of BRCA1. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada390711.

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Payne, Shannon R., and Mary C. King. Transcriptional Regulation of BRCA1. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada392036.

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Payne, Shannon R., and Mary C. King. Transcriptional regulation of BRCA1. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada392061.

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Couch, Fergus. Characterization of BRCA2 Transcriptional Regulation. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada382428.

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Rich, Alexander. Transcriptional Regulation in the Cell Cycle. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada200715.

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Rodenhiser, David I. Transcriptional Regulation and Targeting of NF1 Gene Expression. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada407208.

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Bredow, Sebastian. Transcriptional Regulation of VEGF Expression in Breast Cancer. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada407270.

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Bredow, Sebastian. Transcriptional Regulation of VEGF Expression in Breast Cancer. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada427135.

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Long-Sheng, Chang. Post Transcriptional Regulation of the Neurofibromatosis 2 Gene. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada428293.

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