Dissertations / Theses on the topic 'Transcription; gene regulation; obesity'
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Grossman, Sharon R. (Sharon Rachel). "Combinatorial gene regulation by transcription factors." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/128406.
Full textCataloged from PDF of thesis. "The Table of Contents does not accurately represent the page numbering"--Disclaimer page.
Includes bibliographical references.
Combinatorial gene regulation is encoded in enhancers and promoters in the form of binding sites for transcription factors (TFs), which collaboratively recruit the transcriptional machinery and drive gene expression. Using high-throughput and quantitative technologies developed by our lab and others, we studied TF binding sites in enhancers from numerous different cell types and regulatory systems, shedding light general principles of motif composition and organization in typical cellular regulatory elements. We find extensive synergy between TF binding sites, some with organizational constraints and some with flexible positioning. We demonstrate that different TFs bind at distinct positions within regulatory elements, suggesting a new type of architectural constraint in enhancers. Importantly, our analysis of both TF organization and cooperativity revealed distinctive patterns that separates TFs into potential functional classes. Together, our results suggest a structure of the regulatory code at the level of TF function and generate new hypotheses about regiospecific binding patterns and functions of TF classes within enhancers.
by Sharon R. Grossman.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biology
Deavall, Damian Gregory. "The physiological regulation of cholecystokinin gene transcription." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367183.
Full textDunham, Lee. "Dynamic regulation of growth hormone gene transcription." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/dynamic-regulation-of-growth-hormone-gene-transcription(62354b9b-c755-43b6-a3f0-d108c32232c9).html.
Full textPang, Ting-kai Ronald. "Transcriptional regulation of the human secretin receptor gene /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25059324.
Full textMastrangelo, Peter. "Transcription regulation of the Saccharomyces cerevisiae actin gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27461.pdf.
Full textGarnier, France. "Study of transcription regulation of the gene mdr1." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56986.
Full textLi, Yifan. "Gene regulation by WT1 and related transcription factors." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509772.
Full textJahangiri, Leila. "Combinatorial gene regulation by T-domain transcription factors." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610328.
Full textGay, Robert Daniel. "Neuronal gene regulation by POU family transcription factors." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267026.
Full textTshuikina, Wiklander Marina. "Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9206.
Full textPang, Ting-kai Ronald, and 彭鼎佳. "Transcriptional regulation of the human secretin receptor gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243514.
Full textDalton, Stephen. "Transcriptional regulation of histone gene expression /." Title page, contents and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phd152.pdf.
Full textLee, Tsz-on, and 李子安. "Transcriptional regulation of the human secretin gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30163389.
Full textTrowern, Angus Robert. "Regulation of the neurone-specific protein gene product (PGP) 9.5 gene." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262908.
Full textNygård, Maria. "Regulation of gene transcription by the thyroid hormone receptors /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-756-1/.
Full textHolmqvist, Per-Henrik. "Transcription factor effects on chromatin organisation and gene regulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-453-8/.
Full textMiller, Christian. "Gene regulation during stress response transcription in Saccharomyces Cerevisiae." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155087.
Full textHsu, Yu-Shen. "Regulation of transcription of a developmental gene in Dictyostelium." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268168.
Full textInada, Akari. "The regulation of insulin gene transcription by CREM family." Kyoto University, 2001. http://hdl.handle.net/2433/150503.
Full textYe, Chaoyang. "Transcription regulation of adeno-associated viruses." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4709.
Full text"May 2007" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.
Sasmono, R. Tedjo. "Transcriptional regulation of c-fms gene expression /." [St. Lucia, Qld.], 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17479.pdf.
Full textWong, Kam Wai. "Gene expression and transcriptional regulation of the mouse frizzled related protein-4 gene /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202002%20WONGK.
Full textIncludes bibliographical references (leaves 95-108). Also available in electronic version. Access restricted to campus users.
Kiełbasa, Szymon M. "Bioinformatics of eukaryotic gene regulation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2006. http://dx.doi.org/10.18452/15562.
Full textUnderstanding the mechanisms which control gene expression is one of the fundamental problems of molecular biology. Detailed experimental studies of regulation are laborious due to the complex and combinatorial nature of interactions among involved molecules. Therefore, computational techniques are used to suggest candidate mechanisms for further investigation. This thesis presents three methods improving the predictions of regulation of gene transcription. The first approach finds binding sites recognized by a transcription factor based on statistical over-representation of short motifs in a set of promoter sequences. A succesful application of this method to several gene families of yeast is shown. More advanced techniques are needed for the analysis of gene regulation in higher eukaryotes. Hundreds of profiles recognized by transcription factors are provided by libraries. Dependencies between them result in multiple predictions of the same binding sites which need later to be filtered out. The second method presented here offers a way to reduce the number of profiles by identifying similarities between them. Still, the complex nature of interaction between transcription factors makes reliable predictions of binding sites difficult. Exploiting independent sources of information reduces the false predictions rate. The third method proposes a novel approach associating gene annotations with regulation of multiple transcription factors and binding sites recognized by them. The utility of the method is demonstrated on several well-known sets of transcription factors. RNA interference provides a way of efficient down-regulation of gene expression. Difficulties in predicting efficient siRNA sequences motivated the development of a library containing siRNA sequences and related experimental details described in the literature. This library, presented in the last chapter, is publicly available at http://www.human-sirna-database.net
Göndör, Anita. "Epigenetic Regulation of Higher Order Chromatin Conformations and Gene Transcription." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8296.
Full textCheng, Kwai Wa. "Transcription regulation of human gonadotropin-releasing hormone receptor gene expression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61070.pdf.
Full textKolodziej, Katarzyna Ewa. "Characterization of transcription factor complexes involved in globin gene regulation." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/11813.
Full textDallosso, Anthony Richard. "Epigenetic regulation and transcription at the Wilms' tumour suppression gene." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288408.
Full textRichmond, Laura. "Development of engineered CRISPR transcription factors for programmable gene regulation." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30942/.
Full textSykes, Michelle Christine. "Regulation of endothelial gene transcription by shear stress in a." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24824.
Full textCommittee Chair: Jo, Hanjoong; Committee Member: Griendling, Kathy; Committee Member: Harrison, David; Committee Member: Wang, May; Committee Member: Yoganathan, Ajit.
Finch, Rosalynde J. "Regulation of interleukin-2 gene transcription in CD8 positive cells /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8352.
Full textVUILLAUMIER, BARROT SANDRINE. "Etude de la regulation transcriptionnelle du gene cftr." Paris 5, 1997. http://www.theses.fr/1997PA05N062.
Full textSmith, Stuart Barrie. "The role of transcription factor IUF1 in the regulation of insulin gene transcription by nutrients." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361786.
Full textEl-Kady, A. "A study on regulation of a transcription factor CTCF, by phosphorylation." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275324.
Full textTsai, Pei-Fang. "TAF1 regulation of gene expression genome-wide localization and transcription profiling /." Diss., [Riverside, Calif.] : University of California, Riverside, 2010. http://proquest.umi.com/pqdweb?index=0&did=2019822761&SrchMode=2&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1273863805&clientId=48051.
Full textIncludes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed April 24, 2010). Includes bibliographical references. Also issued in print.
Rada-Iglesias, Alvaro. "From Single Gene to Whole Genome Studies of Human Transcription Regulation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7463.
Full textSubramaniam, Nanthakumar. "Transcription factors involved in negative and positive gene regulation by glucocorticoids /." Stockholm, 1999. http://diss.kib.ki.se/1999/19990115subr/.
Full textHuang, Charlie Chia Wei. "Regulation of Cat-1 gene transcription during physiological and pathological conditions." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270242874.
Full textDonovan, Benjamin Thomas. "Nucleosome Regulation of Transcription Factor Binding Kinetics: Implications for Gene Expression." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574774626880568.
Full textChang, Miao. "Cell type specific regulation of human placenta growth factor gene transcription /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1597612421&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Full text"Department of Molecular Biology, Microbiology and Biochemisty." Includes bibliographical references (p. 123-150). Also available online.
Khoyratty, Tariq. "Interferon regulatory factor 5 : a systematic study of macrophage gene regulation." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:b820f612-ceb7-4e2c-af26-52999e368c41.
Full textXia, Ninuo. "Non-coding RNA's role in epigenetic gene regulation." Diss., UC access only, 2009. http://proquest.umi.com/pqdweb?index=109&did=1871884811&SrchMode=1&sid=1&Fmt=7&retrieveGroup=0&VType=PQD&VInst=PROD&RQT=309&VName=PQD&TS=1270486124&clientId=48051.
Full textIncludes abstract. Includes bibliographical references (leaves 105-122). Issued in print and online. Available via ProQuest Digital Dissertations.
Panjaworayan, Nattanan, and n/a. "Post-transcriptional regulation of gene expression in Hepatitis B virus." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071218.143835.
Full textJawdekar, Gauri W. "Transcriptional regulation of the human small nuclear RNA gene family." Diss., Connect to online resource - MSU authorized users, 2006.
Find full textTitle from PDF t.p. (viewed on June 19, 2009) Includes bibliographical references. Also issued in print.
Hock, Thomas D. "Regulation of the human heme oxygenase-1 gene." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/hock.pdf.
Full textEisen, Timothy George Quentin. "Regulation of cell type-specific gene expression in melanocytes and melanoma." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336364.
Full textGrzeskowiak, Rafal. "Involvement of the paired-domain transcription factor Pax6 in the regulation of glucagon gene transcription by insulin." Doctoral thesis, [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961362200.
Full textHo, Siu-hong. "Characterization of the transcriptional regulation of C. elegans mab-21 gene and its genetic partner, a sin3-like gene /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202002%20HO.
Full textIncludes bibliographical references (leaves 175-187). Also available in electronic version. Access restricted to campus users.
Almeida, Diego Melo. "Regulation of the OsNHX1 Gene Expression: Identification and Characterization of Novel Transcription Factors." Doctoral thesis, Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de Lisboa, 2016. http://hdl.handle.net/10362/51890.
Full textinfo:eu-repo/semantics/publishedVersion
West, Adam Geoffrey. "Molecular interactions of the MADS-box transcription factors." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362415.
Full textDunn, Stephanie May. "Transcription factors involved in regulation of immune and haemopoietic cytokine gene expression." Adelaide Thesis (Ph.D.) -- University of Adelaide, Department of Microbiology and Immunology, 1993. http://hdl.handle.net/2440/21642.
Full textThesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1993