Dissertations / Theses on the topic 'Trachea'
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Lynch, Thomas John. "Adult stem cells in the trachea and tracheal submucosal glands." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/6464.
Yamashita, Masaru. "Regeneration of the larynx and trachea." Kyoto University, 2007. http://hdl.handle.net/2433/135671.
Sellitri, Francesco <1968>. "Trapianto eterotopico della trachea: studio sperimentale." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/447/1/Tesi_Sellitri_Francesco.pdf.
Sellitri, Francesco <1968>. "Trapianto eterotopico della trachea: studio sperimentale." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/447/.
Sugano, Yoshimi Teresa. "Bronchoskopische Vermessung und dreidimensionale Darstellung der Trachea." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15419.
In this paper a new bronchoscopic method was developed and tested, that performs measuring both cross-sectional areas and length of central airway stenoses in real-time. Furthemore this method enables to represent a three-dimensional reconstruction of the airway section that was analysed. To measure th cross-section area, a laser probe inserted into the operating channel of a bronchoscope projects a ring of light onto the trachal wall and marks the cross-sectional area. A new software especially developed for this method makes it possible to identify the projected ring of light and measures the cross-sectional area after applying lens distortion correction algorithms. By saving a succession of cross-sections 3D-data is provided for visualizing and volume calculation. The measuring accurracy was first tested employing plastic tubes with known diameters and 17 models of porcine trachea. The cilinical evaluation was realized in a pilot study. Sections of different length of tracheas of 10 patients were analysed by both the new method and by CT. The results of the experimental part showed good correlation between the reference methods and a very good reliability. The correlation between CT and bronchoscopic measuring results was slightly less good than the experimental correlation, but they showed no systematic measuring error. A little systematic error in the experimental evaluation prooved to be irrelevant for clinical results. The new method enabels objective description of stenoses and makes it possible to develop a standardized classification. In future indvidual stent construcions or calculation of tumor volumes are conceivable.
Okuyama, Hideaki. "Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea." Kyoto University, 2020. http://hdl.handle.net/2433/253142.
Hemphälä, Johanna. "Genetic dissection of tubulogenesis in the Drosophila trachea /." Stockholm : Department of Developmental Biology, Wenner-Gren institute, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-430.
Khawaja, Aamir Mahmoud. "Inhibition of neurogenic mucus secretion in ferret trachea." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286452.
Sakaguchi, Yasuto. "Development of a novel tissue-engineered nitinol-frame artificial trachea with native-like physical characteristics." Kyoto University, 2018. http://hdl.handle.net/2433/235063.
Karkhanis, Teja. "Intra-animal and Inter-animal Variations in the Biomechanical Properties of Tracheal Cartilage Rings." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037942.
Hermawan, Vera. "Experimental techniques to determine the Young's Modulus of the trachea thesis submitted in partial fulfilment of the degree of Master of Engineering, Auckland University of Technology, September 2004." Full thesis. Abstract, 2004.
Amoako, Daniel Kwasi. "Cyclopiazonic acid changes the mode of excitation-contraction coupling in acetylcholine-stimulated bovine tracheal smooth muscle /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1865017X.
Ramnarine, Sean Issac. "Neurogenic mucus secretion in ferret trachea : excitatory and inhibitory control." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338873.
鄧兆庭 and Siu-ting Alvin Tang. "Implementation and evaluation of evidence-based practice guidelines for open endotracheal suctioning in mechanically-ventilated adult patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193027.
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Kurujareon, Jutarat. "Simulation of airflow in the human tracheobronchial network." Thesis, University of Hertfordshire, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391374.
Боханов, Г. Ю., and В. Ф. Кривецький. "Моделювання аллопротезу для оптимізації циркулярної подовженої резекції трахеї." Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/57997.
Fabre, Dominique. "Reconstruction trachéale autologue." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114835.
Autologous tracheal reconstruction has been standardized and optimized in parallel with the development of experimental research and clinical practice. This is a therapeutic solution that replaces reproducibly more than 50% of tracheallength. All the other tracheal replacement techniques, developed by many teams and their experimental and clinical results, were studied and classified according to the substitute used.After an experimental study at the Laboratory of Surgical Research in the Marie Lannelongue, center, we started to work towards the use of autologous tissue (free flaps and costal cartilages). Thoses tissues were shaped using technical advances including microsurgery to create a new tracheal conduit.This tracheal substitute does not contain any prosthetic material. It may therefore resist to infection and it resists to respiratory pressures and especially respiratory depression.The development of this technique was conducted in parallel with research studies, that improved and optimized the surgical process and the results.The first experimental work was the creation of an animal model tracheal replacement using an armed autologous pedicle flap. We confirmed the strength and viability of the cartilage strip inserted between the dermal layers and the sustainability of this type of reconstruction.The following work was carried out in collaboration with two other teams specialized in Tissue Engineering.The first experimental work of tissue engineering tried to produce cartilage rings from stem cells. The objective was to obtain complete cartilaginous rings that could be inserted into the thickness of the flap.The next objective was to develop a technique to transform the superficial layer of the skin in a respiratory epithelium. Four tissue engineering techniques were used and tested: peritoneum of the graft, oral mucosa transplant, seeding cells from the tracheal mucosa and graft culture respiratory epithelial cells.Despite advances in technology, the culture of cartilage cells in three dimensions on Silicone mold were not viable and could not be used in clinical practice.The various alternative processes of skin covering highlighted the need for additional steps in advance of surgery.Among the techniques used to replace the epithelium with an expanded graft buccal mucosa, transplantation of culture respiratory epithelium is the most reliable.Autologous reconstruction is so far the best alternative for extended tracheal replacement using only autologous tissue. The pursuit of an experimental approach is fundamental to improve our results.Thus, this work will be pursued by an experimental work on the replacement of cartilage rings using porous titanium ring on an animal model
Nunes, Sandro Filipe Fernandes. "Influenza A infection dynamics in an Ex vivo organ culture of pig trachea." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609311.
Partington, L. "Development of a pressurised transmural decellularisation method for application in tissue engineering trachea." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1465826/.
Borthwick, Duncan William. "An investigation of murine trachea cellular kinetics : implications for stem cell gene therapy." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21636.
Amendola, Richard Lee. "Graph-based segmentation of the pediatric trachea in MR images to model growth." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/2810.
Negosanti, Luca <1981>. "Allotrapianto di trachea: studio anatomico sull'utilizzo del lembo ALT nell'allestimento del trapianto composito." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7703/1/negosanti_luca_tesi.pdf.
Trachea surgery has always been a challenge for the surgeon in view of remarkable difficulty in restoring the anatomy and the function. Currently revascularized human trachea transplantation is not possible due to the lack of a single vascular pedicle. In 2008 Paul Delaere described a tracheal transplantation technique using a cadaveric donor. The chinese flap used by Delaere to harvest the compiste flap is a good alternative, but today perforator flaps represent a better choice. The possibility to use the anterolateral thigh perforator flap in place of the chinese flap was studied on cadavers in the present stduy.
Negosanti, Luca <1981>. "Allotrapianto di trachea: studio anatomico sull'utilizzo del lembo ALT nell'allestimento del trapianto composito." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7703/.
Trachea surgery has always been a challenge for the surgeon in view of remarkable difficulty in restoring the anatomy and the function. Currently revascularized human trachea transplantation is not possible due to the lack of a single vascular pedicle. In 2008 Paul Delaere described a tracheal transplantation technique using a cadaveric donor. The chinese flap used by Delaere to harvest the compiste flap is a good alternative, but today perforator flaps represent a better choice. The possibility to use the anterolateral thigh perforator flap in place of the chinese flap was studied on cadavers in the present stduy.
Roberts, Andrew T. "Aerosol delivery of mammalian cells for tissue engineering." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0429103-192655.
Boers, James Evan. "Composition and proliferation of normal human tracheobronchial mucosa." Maastricht : Maastricht : Datawyse/Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5926.
Tonning, Anna. "Genetic and molecular regulation of epithelial tube morphogenesis /." Göteborg : Institute of Biomedicine, Sahlgrenska Academy, Göteborg University, 2006. http://hdl.handle.net/2077/704.
Belchior, Luciana Dias. "Estudo das alteraÃÃes da contratilidade de anÃis de traquÃia isolada de ratos em resposta ao carbacol e ao potÃssio apÃs treinamento fÃsico." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5151.
A presente pesquisa visou determinar a contratilidade do mÃsculo liso traqueal de ratos submetidos a exercÃcio leve de curto prazo, ou seja, treinados 1h ou prÃ-treinados e posteriormente exercitados por 1, 5 e 10 hs (PT1, PT5 e PT10, respectivamente), bem como de animais sensibilizados com OVA, submetidos ao exercÃcio por 5hs e posteriormente desafiados, com o objetivo de verificar as alteraÃÃes causadas pelo exercÃcio neste mÃsculo determinando tambÃm a interferÃncia da broncoprovocaÃÃo antigÃnica sobre a contratilidade traqueal de animais previamente exercitados. Para a realizaÃÃo da pesquisa, ratos machos (250-350g) foram submetidos a diferentes protocolos de nado, por 1, 5 e 10hs, sendo um grupo submetido à sensibilizaÃÃo com OVA e, 21 dias depois, desafiados em intervalos de 15 minutos atravÃs da inalaÃÃo do antÃgeno sensibilizante (grupo S/D). No grupo sensibilizado e submetido ao exercÃcio, este Ãltimo foi realizado durante 5 dias antes do desafio (grupo S/E prà desafio). O sacrifÃcio dos animais ocorreu 30 min apÃs a sessÃo de nado ou 24 horas apÃs o desafio antigÃnico no caso dos animais submetidos ao modelo de asma. Os ratos sedentÃrios nÃo foram submetidos a nenhum treino. Os controles do grupo asma inalaram apenas o veÃculo (NaCl 0,9%). Para os experimentos in vitro a traquÃia foi removida e montada em cuba para ÃrgÃo isolado contendo 5ml de soluÃÃo Tyrod (mantida a 37  0,5 ÂC) e aerada com mistura de O2. Foram confeccionadas curvas concentraÃÃo-efeito (CCE) para carbacol e cloreto de potÃssio. Os resultados mostraram que o pD2 nÃo apresentou valores significativos nos grupos em estudo, exceto em PT5 e PT10, ambos em relaÃÃo ao grupo PT1. A resposta mÃxima (%) apresentou valores significativamente crescentes e maiores nos grupos PT1 (107,62  3,57),PT5 (116,35  0,54) e PT10 (123,50  2,59) em relaÃÃo ao grupo sedentÃrio (82,70  5,90), quando o carbacol foi utilizado como estÃmulo contrÃtil. SituaÃÃo semelhante ocorreu nos grupos PT1 (105,19 Â1,12), PT5 (112,02  1,44) e PT10 (119,56  0,95) em relaÃÃo ao grupo sedentÃrio (90,45  2,22), para o potÃssio e nos grupos S/D (100,74  4,79) e S/E prÃ-desafio (109,09 Â3,68) em relaÃÃo ao grupo sensibilizado (82,69 Â5,90) para o carbacol, e nos grupos S/D (105,50  2,37) e S/E prÃ-desafio (115,05  1,96) em relaÃÃo ao grupo sensibilizado (93,11  3,58). Para verificar a participaÃÃo do Ãxido nÃtrico, acetilcolina e estresse oxidativo no mecanismo da aÃÃo prÃcontrÃtil da musculatura lisa traqueal induzida pelo exercÃcio foram determinados, respectivamente os nÃveis de nitrito, atividade da acetilcolinesterase (AChE) e espÃcies reativas ao Ãcido tiobarbitÃrico (TBARs) como uma maneira de determinar a peroxidaÃÃo lipÃdica. Os valores de nitrito foram significativos para o grupo PT5 em relaÃÃo aos grupos sedentÃrio e treinado 1h. Nos animais submetidos ao protocolo da asma ocorreu queda significativa dos nÃveis de nitrito nos grupos S/D e S/E prÃ-desafio. Ocorreu aumento da peroxidaÃÃo lipÃdica nos grupos PT1, PT5 e PT10 em relaÃÃo ao grupo sedentÃrio. Jà no grupo asmÃtico, os valores foram significativamente maiores nos grupos S/D e S/E prÃdesafio em relaÃÃo ao grupo controle. A atividade da AChE apresentou reduÃÃo significativa nos grupos PT1, PT5 e PT10 em relaÃÃo aos grupos sedentÃrio e treinado 1h. No grupo asmÃtico, tambÃm ocorreu reduÃÃo na atividade da AChE nos grupos S/D e S/E prÃ-desafio. Portanto, os resultados mostram que o exercÃcio a curto prazo aumenta a contratilidade da musculatura lisa traqueal isolada em ratos, para o carbacol e o potÃssio dos grupos em estudo; provavelmente com a participaÃÃo do Ãxido nÃtrico, acetilcolina e peroxidaÃÃo lipÃdica neste mecanismo prÃ-contrÃtil.
This work aimed to determine the contractility of tracheal smooth muscle of rats submitted to short-term light exercise, trained for 1h or pre-trained and, then, trained for 1, 5 and 10hs (PT1, PT5 and PT10, respectively), as well as, animals sensitized with OVA, submitted to exercise for 5hs and subsequently challenged, with the objective of verifying the changes caused by exercise in this muscle, also determining the interference of antigen bronchoprovocation on the contractility of tracheal smooth muscle of animals previously exercised. To conduct the study male rats (250-350g) were subjected to different protocols of swimming, by 1, 5 and 10hs, in addition to one group that was subjected to sensitization with OVA and 21 days later, challenged at intervals of 30 min through sensitizing antigen inhalation (group S/D). In the sensitized group submitted to exercise, this latter was held for 5 days before OVA challenge (group S/E pre-challenge). The animals were sacrificed 15 min after the swimming session or 24 hs after antigen challenge, in the case of rats submitted to asthma model. Sedentary rats were not subjected to any training session. Asthma control group inhaled only the vehicle (NaCl 0.9%). For in vitro experiments the trachea was removed and mounted in an isolated organ bath containing 5ml of Tyrode solution (maintained at 37 Â 0.5 ÂC) and aerated with O2. Concentration-effect curves (CEC) were designed for carbachol and potassium chloride. The results showed that the pD2 values were not significant among the groups except in PT5 and PT10, both in relation to group PT1. The maximum response values were significantly increased and higher in the groups PT1 (107,62 Â 3,57), PT5 (116,35 Â 0,54) and PT10 (123,50 Â 2,59) compared to the sedentary group (82.70 Â 5,90), when carbachol was used as the contractile stimulus. A similar situation occurred in the groups PT1 (105,19 Â 1,12), PT5 (112,02 Â 1,44) and PT10 (119,56 Â 0,95) as compared to the sedentary group (90,45 Â 2,22), for potassium and S/D (100,74 Â 4,79) and S/E pre-challenge groups (109,09 Â 3,68) as compared to the sensibilized group (82,69 Â 5,90) for carbachol, as well as, S/D (105,50 Â 2,37) and S/E pre-challenge (115,05 Â 1,96) groups when compared to the sensibilized one for potassium (93,11 Â 3,58). To verify the involvement of nitric oxide, acetylcholine, and oxidative stress on the pro-contractile mechanism of the tracheal smooth muscle induced by exercise, nitrite levels, acetylcholinesterase (AChE) activity and thiobarbituric acid reactive species (TBARS), as a way of determining lipid peroxidation, were determined. Nitrite levels decreased in the PT5 group as compared to sedentary and 1h trained groups. In the animals subjected to the asthma protocol there was a significant decrease in the nitrite levels in the S/D and S/E prechallenge groups. An increase in lipid peroxidation occurred in the groups PT1, PT5 and PT10 in relation to the sedentary one. In the asthmatic group, the TBARS values were significantly higher in S/D and S/E pre-challenge groups as compared to the control one. The AChE activity showed a significant reduction in the groups PT1, PT5 and PT10 in relation to sedentary and 1h trained groups. The groups S/D and S/E pre-challenge also presented a decrease on AChE activity. Therefore, the results showed that short-term light exercise increases the tracheal smooth muscle contractility of the study groups, probably with the participation of nitric oxide, acetylcholine, and lipid peroxidation in this pro-contractile mechanism.
Geers, Teresa Anne. "The effect of subinhibitory concentrations of antibiotics on Pseudomonas aeruginosa infection /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011222273.
Liu, Yu. "Immunosuppressant-free allotrasplantation of the trachea : The antigenicity of tracheal grafts can be reduced by removing the epithelium and mixed glands from the graft by detergent treatment." Kyoto University, 2000. http://hdl.handle.net/2433/151405.
Sands, Joyce Ann 1958. "THE INCIDENCE OF PULMONARY ASPIRATION IN INTUBATED PATIENTS RECEIVING ENTERAL NUTRITION THROUGH WIDE- AND NARROW-BORE NASOGASTRIC FEEDING TUBES." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276693.
Günther, Catherine Pascale [Verfasser]. "Untersuchungen zur mikrobiellen Besiedlung von Rachen und Trachea bei Bartagamen (Pogona spp.) / Catherine Pascale Günther." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1046709941/34.
Salehi, Mehran. "Experimental Assessment of the Laryngeal Jet Effect on the Fluid Flow Pattern within the Trachea." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470386999.
Tabcheh, Lina. "Tracheal mineralization : cellular and molecular mechanisms in mice." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0239/document.
The trachea is a very complex structure of the respiratory tract, composed of C-shaped cartilaginous rings, made of hyaline cartilage, and muscular bands, made of smooth muscle cells, conferring rigidity and compliance to the windpipe, respectively. In contrast to other intensely studied cartilages such as the ones found in the developing growth plate and in the adult joints or smooth muscle cells from the vasculature, very little information is available on the development of the tracheal cartilage and smooth muscle tissues and on their innate propensity to mineralize, although calcification of the trachea is a common finding in the elderly population and also a rare manifestation of pathologic conditions. In this context, this PhD work sought to better characterized the poorly studied tracheal cartilage and smooth muscle tissue and understand the molecular mechanisms regulating tracheal mineralization that has been unexplored so far. We tackle these questions in the mouse model. Setting up a novel in-vitro culture of tracheal cells, we demonstrated that tracheal chondrocytes and smooth muscles cells are prone to mineralize when treated with high level of Pi, through different molecular mechanisms. In parallel, we found that in vivo mineralization of the trachea only happens in the cartilaginous rings, as early as 30 days after birth. Histological and molecular evidence suggest that tracheal mineralization occurs through a BMP-dependent rostro-caudal progression
Tsuji, Takuya. "Long-term preservation of planar cell polarity in reversed tracheal epithelium." Kyoto University, 2018. http://hdl.handle.net/2433/232475.
Schulte, Dagmar [Verfasser]. "Der Einfluss von Tumornekrosefaktor-alpha auf den ziliären Transport in der Trachea der Maus / Dagmar Schulte." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1069065366/34.
Braxton, Joi Requan. "Effect of preload on the response of mouse trachea smooth muscle to cholinergic stimulation a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=33&CISOBOX=1&REC=10.
Loan, Lori A. "The relationship between ventilator inspired gas temperature and tracheal injury in neonates /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/7316.
Marcus, Hilda. "Adherence of Pseudomonas aeruginosa to perfused tracheal epithelium : adhesin [i.e. adhesion] - receptor interactions /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259580261697.
Marquardt, Claudio David [Verfasser]. "Funktionsuntersuchungen zum Einfluß von Temperatur auf den ziliären Transport in der Trachea von Mäusen / Claudio David Marquardt." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1078220271/34.
Shibeshi, Alemayehu Workineh. "Etablierung und Charakterisierung primärer equiner Trachealepithelzellen: Ein in vitro-Modell zur Untersuchung der Expression und Funktion pulmonaler beta-adrenerger Rezeptoren." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-38013.
Roethlisberger-Holm, Karin. "Transtracheal pressure recordings in the exercising horse /." Uppsala : Sveriges lantbruksuniv, 1995. http://epsilon.slu.se/avh/1995/91-576-4956-1.gif.
Amoako, Daniel Kwasi. "Cyclopiazonic acid changes the mode of excitation-contraction couplingin acetylcholine-stimulated bovine tracheal smooth muscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B3121387X.
Servin, Silvio Oscar Noguera. "Tubo endotraqueal atraumático para ventilação mecânica." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313790.
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Mèdicas
Made available in DSpace on 2018-08-17T20:11:17Z (GMT). No. of bitstreams: 1 Servin_SilvioOscarNoguera_D.pdf: 954922 bytes, checksum: 98d734a92e137d605954e5dfefe3a20a (MD5) Previous issue date: 2011
Resumo: Introdução: Pacientes que necessitam permanecer sob intubação endotraqueal por longos períodos ou que são submetidos à anestesia geral, poderão ter lesão na luz da traquéia devido a pressões exercidas pelo balonete terminal do tubo endotraqueal (TET). Em alguns casos, estas lesões no epitélio poderão evoluir para estenose ou ocasionalmente necrose. Objetivo: Apresentar um modelo de tubo endotraqueal modificado (TETM) em que a pressão do balonete é variável com o ciclo da ventilação mecânica, sendo o mesmo avaliado em simulador pulmonar e animal. Método: Em simulador pulmonar acoplado a ventilador mecânico (VM) ajustado para dois volumes correntes (VC) de 10 e 15 mL/Kg e complacência de 60 mL/cmH²0, foram utilizados dois modelos de tubos endotraqueais para avaliar a eficiência da ventilação do TETM. O primeiro, identificado como modificado (TETM), e o segundo como convencional (TETC) ambos de número 7,5 mm e 8,0 mm. Foi ainda realizado comparação entre os dois modelos de tubos em suinos da raça Large White sob anestesia geral e VM por período de 48 horas contínuas, sendo os animais posteriormente eutanasiados para análise histopatológica das traquéias. Resultados: Ambos TETM (7,5 e 8,0 mm) apresentaram escape de ar no simulador pulmonar. O menor escape (13%) foi observado no TETM de 7,5 mm com VC = 15 mL/Kg e o maior escape (32%) no TETM de 8,0 mm com VC = 10 mL/Kg. Apesar disto, ambos TETM apresentaram boa eficiência no simulador pulmonar. Na avaliação do uso dos TET em porcos, a análise histopatológica dos cortes seriados de suas traquéias foi observado que o TETM causou menos áreas traumáticas em seu epitélio tanto macro como microscopicamente, quando comparado com o TETC. Conclusão: O uso de novo modelo de TET poderá diminuir o risco da ocorrência de lesão traqueal sem prejuízo relevante para a mecânica respiratória
Abstract: Introduction: Patients who need to undergo endotracheal intubation for a long periods or who are under general anesthesia, may have damage in the trachea light due to pressure from the cuff end. In some cases, the lesions in the tracheal epithelium may progress to stenosis or occasionally necrosis. Objective: Show a modified endotracheal tube (TETM) in both a lung simulator and animals in which the cuff pressure is variable according to the mechanical ventilation cycle. Method: In a lung simulator coupled to a mechanical ventilator (MV) fitted with two tidal volumes (Vt) (10 and 15mL/Kg) and compliance of 60mL/cmH20, two types of endotracheal tubes were used: modified (TETM) and conventional (TETC) with numbers 7.5 and 8.0 in order to evaluate the efficiency of TETM ventilation. There was also a comparison between two pipe models in MV anesthetized pigs for a period of 48 hours after which the animals were put down and a histopathology of the tracheas was carried out. Results: Both TETMs (7.5 and 8.0) had air leaks in the lung simulator. The smallest air leak (13%) was observed at 7.5 with TETM VC = 15 mL / kg and the highest (32%) at 8.0 with TETM VC = 10 mL / kg. In spite of that, both TETM showed good efficiency at lung simulator. From histopathological evaluation, in serial sections of the animals' trachea, we observed that TETM caused less traumatic areas in their epithelium, both macro and microscopically, when compared to TETC. Conclusion: The use of this new TETM may decrease the risk of occurrence of tracheal injury without relevant damage in respiratory mechanics
Doutorado
Fisiopatologia Cirúrgica
Doutor em Ciências da Cirurgia
Nasr, Talia S. "Identification of Hedgehog/Gli Targets during Tracheoesophageal Development." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593273349807685.
Haberman, Adam. "The role of trachealess and serrate in the development of the salivary glands and trachea of drosophila melanogaster." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/308067.
Graulich, Tilman [Verfasser]. "Stereologische Untersuchungen der Gas-Austauschregion der Lunge und der Innervation der Trachea bei der tumorkachektischen Maus / Tilman Graulich." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/1140734997/34.
Lemaitre, Philippe. "Early role of IL-17 and calcineurin inhibitor-mediated Th2- and Th17-polarization of chronic trachea allograft rejection pathways." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209243.
We first demonstrated that interleukin-17 contributes to inflammatory lesions in the early phase post-transplantation. Interleukin-17 was found to be produced by &61543;&61540;+ T cells and CD4+ T cells infiltrating the graft and interleukin-17 neutralization significantly reduced the development of epithelial lesions together with inhibition of interleukin-6 and heat-shock-protein 70 gene transcription.
We then investigated the contribution of interleukin-17 to obliterative airway disease. Although interleukin-17 did not play a dominant role in absence of immunosuppression, it was found to contribute to airway pathology in animals receiving cyclosporin A. Under this treatment, we first observed dramatic changes in the composition of the lymphocyte populations infiltrating the graft: the numbers of CD8+ T cells producing interferon-&61543; and type 1 CD4+ T cells were dramatically decreased while the numbers of type 17, and also type 2 CD4+ T cells were unaffected. The pathological relevance of these findings was first demonstrated by the prolongation of graft survival afforded by the depletion of CD4+ T cells in cyclosporin A-treated animals. Furthermore, graft rejection was also delayed in mice genetically deficient in either interleukin-17 or interleukin-4, providing evidence that type 17 and type 2 CD4+ T cells actively contribute to graft rejection in cyclosporin A-treated recipients. On the other hand, parallel experiments in interferon-&61543;-deficient mice revealed that interferon-&
Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished
Sabarinathan, Ranjani. "Development of a Software Application to Extract the Features of Normal Respiratory Sounds from the Lungs and the Trachea." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1838.
Soares, Semyramis Maria Freire [UNESP]. "Comparação do uso do tubo traqueal com balonete preenchido com ar, solução fisiológica ou lidocaína alcalinizada a 1% e a 0,5% em pacientes pediátricos." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/100137.
A intubação traqueal de pacientes pediátricos, especialmente de crianças com idade inferior a oito anos, foi por muito tempo realizada exclusivamente com uso de tubos traqueais sem balonete devido ao risco do mesmo causar lesão na mucosa traqueal. Diversos estudos demonstraram a possibilidade do uso de cânulas traqueais com balonete de alta complacência e baixa pressão em crianças sem ter ocorrido aumento do risco de lesões de via aérea. O emprego da lidocaína alcalinizada no preenchimento do balonete apresentou diminuição na incidência de morbidade laringotraqueal no pós-operatório em adultos. Contudo, não há estudos comparando o uso de balonete preenchido com lidocaína alcalinizada e seus benefícios na população pediátrica. Comparar a utilização de cânulas traqueais com balonetes preenchidos com solução fisiológica, ar ou lidocaína alcalinizada a 1% e a 0,5% na prevenção de morbidades laringotraqueais, da agitação e da alteração hemodinâmica, no período pós-operatório, em pacientes com idade de três a 13 anos submetidos à anestesia geral. Cento e sessenta e quatro pacientes pediátricos submetidos à anestesia geral balanceada foram distribuídos em quatro grupos, de acordo com o preenchimento do balonete do tubo traqueal: grupo SF (n 41) preenchido com solução fisiológica 0,9%; grupo AR (n= 41) preenchido com ar ambiente; grupo L1% (n=41) preenchido com lidocaína alcalinizada a 1%; grupo L 0,5% (n=41) preenchido com lidocaína alcalinizada a 0,5%. Os balonetes foram lubrificados com gel hidrossolúvel antes da intubação traqueal e, após a intubação traqueal, preenchidos com ar ou a solução de acordo com o grupo até ser obtida a pressão de selo. A pressão do balonete foi mantida abaixo ou igual a 20 cm H2O. Os dados relativos aos atributos hemodinâmicos...
Tracheal intubation in pediatric patients, especially children under 8 years old, was for long performed exclusively with uncuffed tracheal tubes due to the risk of tracheal mucosal damage. Several studies have demonstrated the possibility of the use of cuffed tracheal tube with high compliance and low pressure in children. Its use has occurred without increasing risk of airway injury. The use of alkalized lidocaine filling the cuff showed a decrease in the incidence of laryngotracheal morbidity in adults postoperatively. However, there are no studies comparing the use of cuff filled with alkalinized lidocaine and its benefits in the pediatric population. compare the use of cuffed tracheal tubes filled with saline, air or alkalized 1% and 0.5% lidocaine in preventing laryngotracheal morbidity, and hemodynamic changes in the postoperative period in patients aged between 3 and 13 years undergoing general anesthesia. one hundred sixty four pediatric patients undergoing balanced general anesthesia were divided into four groups, according to the filling of the tracheal tube cuff: saline group (n=41) filled with 0.9% saline; AR group (n=41) filled with ambient air; L1% group (n=14) filled with alkalinized 1% lidocaine; group L 0.5% (n=41) filled with alkalinized 0.5% lidocaine. All cuffs were lubricated with water-soluble gel before tracheal intubation. After tracheal intubation, they were filled until reaching sealing pressure. The cuff pressure was kept below or equal to 20 cm H2O. Data on respiratory and hemodynamic parameters were obtained before intubation and after 30, 60, 90 and 120 minutes of anesthesia and at the end of surgery, immediately before and after extubation. After 30 minutes of intubation, a sample of peripheral venous blood was collected from patients who had the cuffs filled with lidocaine for determination of its plasma concentration... (Complete abstract click electronic access below)
Silva, Irene Raimundo dos Santos. "Influência dos corticosteróides nas propriedades biomecânicas da traquéia de coelhas albinas." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-04022005-155455/.
The effects of methilprednisolona in the adults trachea albinos female rabbits were studied. The goal of this study was examine the potential effects of this armorial traction. The animals were divided in two groups. Ten female rabbits of control group received by way of subcutaneous 2mg/kg/day of salt bed diluted solution. These ten female rabbits of the control group also received by way of subcutaneous proportional volumes of salt bed solution. After 21 days, the animals were sacrificed and their trachea were subjected to traction tests and anatomical pathological studies. Animals of the experimental group presented inferior weight significant from the control group in the end of the treatment (C = 8,94 ± 314g X E = 3555 ± 373g). The groups didnt differ from the statistic point of view as regards of the following variables: limit load of proportionality (C = 8,94 ± 1,68 N X E = 8,93 ± 1,52 N); maxim load (C = 9,12 ± 2,2 N X E = 9,57 ± 1,90 N); stretch out on the limit of proportionality (C = (683 ± 2,08) x '10 POT.-3' m X E = (6,05 ± 1,50) x '10 POT.-3' m); maxim stretch out (C = (7,44 ± 2,60) x '10 POT.-3' J X E = (6,85 ± 1,55) x '10 POT.-3' J); absorbed energy in the elastic phase (C = 28,70 ± 14,43) x '10 POT.-3' m J X E = (27,75 ± 11,06) x '10 POT.-3' J); rigidity (C = 1,08 ± 0,41) x '10 POT.-3' N/m X E = (1,2 + 0,37) x '10 POT.-3' N/m). It was concluded in the end of the treatment that there werent any morphological and biomechanical alterations of the trachea studied, although, the animals of the experimental group suffered a significant slimming in the end of the treatment when compared with the experimental group