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Journal articles on the topic 'TP3®'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Jung, Jin, Jae-Ho Yoon, Seok Lee, et al. "Measurable Residual Disease in Adult B Lymphoblastic Leukemia: A Study of Concordance between Multiparametric Flow Cytometry, Next-Generation Sequencing of Immunoglobulin Gene Rearrangements, and Quantitative PCR." Blood 144, Supplement 1 (2024): 1468. https://doi.org/10.1182/blood-2024-209989.

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Introduction: Measurable residual disease (MRD) is the strongest independent prognostic factor in B lymphoblastic leukemia (B-ALL). The methods used for MRD monitoring include multiparametric flow cytometry (MFC), next-generation sequencing (NGS) of immunoglobulin gene rearrangements, and quantitative PCR (qPCR). In this study, we aim to evaluate the concordance between these three well-defined MRD assessment methods to better characterize the biology of MRD in adult B-ALL patients. Method: This study involved adult patients aged 19 or older with B-ALL, treated with modified hyper-CVAD (hyperf

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Gois, Marjana, Eliara Pinto Vieira Biaggio, Mirtes Bruckmann, Isadora Pelissari, Rubia Soares Bruno, and Michele Vargas Garcia. "Habilidade de ordenação temporal e nível de especificidade nos diferentes testes tonais." Audiology - Communication Research 20, no. 4 (2015): 293–99. http://dx.doi.org/10.1590/2317-6431-2015-1593.

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RESUMO Objetivo: Avaliar a habilidade de ordenação temporal com diferentes testes, verificar a especificidade desses testes e comparar o resultado com o grau de facilidade/dificuldade relatado pelos sujeitos. Métodos: Os indivíduos realizaram avaliação audiológica básica e Teste Dicótico de Dígitos, para triagem do processamento auditivo, e foram submetidos ao Teste Padrão de Frequência (TPF) e ao Teste Padrão de Duração (TPD), nas versões de Taborga-Lizarro, Musiek e Auditec®, para avaliar a habilidade de Ordenação Temporal. Após, foi apresentada a Escala Visual Analógica (EVA), para que os s

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Stroop, D. M., C. J. Glueck, H. I. Glueck, T. Hamer, T. Tracy, and H. R. Schumacher. "Measurement of tPA antigen: Comparison of tintelize® and imubind® methods." Fibrinolysis 8 (January 1994): 122. http://dx.doi.org/10.1016/0268-9499(94)90626-2.

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Stern, Raphael A., Daniel Stern, Moshe Harpaz, and Shmuel Gazit. "Applications of 2,4,5-TP, 3,5,6-TPA, and Combinations Thereof Increase Lychee Fruit Size and Yield." HortScience 35, no. 4 (2000): 661–64. http://dx.doi.org/10.21273/hortsci.35.4.661.

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Application of TP as Tipimon® or TPA as Maxim® at the young fruitlet stage significantly increased yield in three lychee (Litchi chinensis Sonn.) cultivars: `Mauritius', `Floridian', and `Kaimana'. Application of TP followed by TPA a week later increased yield more than did either substance alone. In all experiments, TPA increased fruit size and weight, relative to both controls and TP-treated trees. The increased yield did not prevent the increase in fruit size. Use of sprays of TPA may be an effective way of satisfying the market demand for large lychee fruit. Chemical names used: 2,4,5-tric

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Zrimsek, Matej, Jakob Gubensek, and Andreja Marn Pernat. "A Pilot Study on the Replacement of Fibrinogen with Fibrinogen Concentrates During Therapeutic Plasma Exchange with Mild to Moderate Bleeding Risk—A Comparison with Fresh Frozen Plasma and Albumin Replacement." Journal of Clinical Medicine 13, no. 24 (2024): 7662. https://doi.org/10.3390/jcm13247662.

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Background: Therapeutic plasma exchange (TPE) removes coagulation factors and leads to depletion coagulopathy. The aim of the study was to compare hemostasis between TPE procedures without coagulation factor replacement (electrolyte group), the partial replacement of fibrinogen with fibrinogen concentrates (fibrinogen group) and partial coagulation factors replacement with fresh frozen plasma (partial FFP group). Methods: A total of 73 TPE procedures in patients with fibrinogen levels 1–2 g/L were divided into three study groups depending on clinically estimated bleeding risk. Standard coagula

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Komommo Omini Abam, Tubonimi Joseph Kio Ideriah, Akuro Ephraim Gobo, and Francis Egobueze. "Bio-remediation of crude oil-contaminated soils in Eleme, Ogoni-land using CLOGEN, MicroSORB®, PRP® and a combination of Electro-Kinetic Action+KEEN®+Ors-SORB plus®." World Journal of Advanced Research and Reviews 25, no. 2 (2025): 142–54. https://doi.org/10.30574/wjarr.2025.25.2.0331.

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This study evaluated the efficiency, effectiveness and ecological impacts of bio-stimulation, bio-augmentation, and electro-bio-remediation interventions in phase-1 Ogoni-land remediated areas, focusing on the rate of Total Petroleum Hydrocarbon (TPH) degradation, soil health, soil physicochemical and biological properties across four selected locations in Eleme, using CLOGEN, MicroSORB®, Petroleum Remediation Product® and a combination of Electro-Kinetic Action plus KEEN® and Ors-SORB plus®. Nkeleoken Alode LOT 04 with the largest total area of 0.64Ha and remediated soil volume of 46,100m3 us

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Lopes Monteiro Neto, João Luiz, José De Anchieta Alves de Albuquerque, Anderson Tiago de Oliveira, et al. "Environments and substrates for “pimenta-de-cheiro” (Capsicum chinense Jacq.) seedling production in the Amazon savana." REVISTA AGRO@MBIENTE ON-LINE 16 (November 6, 2022): 1–15. http://dx.doi.org/10.18227/1982-8470ragro.v16i0.7309.

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Quality seedlings production is one of the most important steps in the cultivation of vegetable species. In this sense, the objective was to evaluate the influence of different environments and substrates on the production of “pimenta-de-cheiro” (Capsicum chinense Jacq.) seedlings in Boa Vista, Roraima. An experiment was installed in a completely randomized design (CRD), with treatmentsarranged in subdivided plots. Five environments were evaluated: AG - agricultural greenhouse; TV35 - red shading net with 35% shading (red ChromatiNet®); TV50 - red shading net with 50% shading (red ChromatiNet®

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van Niekerk, Jan A. "Recent Advances in the BIOX^® Technology." Advanced Materials Research 71-73 (May 2009): 465–68. http://dx.doi.org/10.4028/www.scientific.net/amr.71-73.465.

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The past number of years has seen a sharp rise in the gold price. This has led to renewed activity in the gold sector and especially in refractory ore-bodies that are not economically feasible at lower gold prices. There have, historically, been a total of eleven BIOX® plants commissioned world wide with eight currently in operation. The most recent plants to be commissioned were Bogoso and Jinfeng in 2007 and Kokpatas in Uzbekistan in 2008. Design of the Bogoso BIOX® plant was started by Minproc in 2005. The design throughput of the sulphide BIOX® circuit is 820 tpd concentrate at a feed sulp

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Rahkio, T. M., and H. J. Korkeala. "Use of Hygicult-tpc® in Slaughterhouse Hygiene Control." Acta Veterinaria Scandinavica 38, no. 4 (1997): 331–38. http://dx.doi.org/10.1186/bf03548479.

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Boughton, Philip, James Merhebi, C. Kim, et al. "An Interlocking Ligamentous Spinal Disk Arthroplasty with Neural Network Infrastructure." Journal of Biomimetics, Biomaterials and Tissue Engineering 7 (October 2010): 55–79. http://dx.doi.org/10.4028/www.scientific.net/jbbte.7.55.

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An elastomeric spinal disk prosthesis design (BioFI™) with vertebral interlocking anchors has been modified using an embedded TiNi wire array. Bioinert styrenic block copolymer (Kraton®) and polycarbonate urethane (Bionate®) thermoplastic elastomer (TPE) matrices were utilized. Fatigue resistant NiTi wire was pretreated to induce superelastic martensitic microstructure. Stent-like helical structures were produced for incorporation within homogenous TPE matrix. Composite prototypes were fabricated in a vacuum hot press using transfer moulding techniques. Implant prototypes were subject to axial

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Bailey, Olivia, Ljiljana Zlatanovic, Jan Peter van der Hoek, et al. "A Stochastic Model to Predict Flow, Nutrient and Temperature Changes in a Sewer under Water Conservation Scenarios." Water 12, no. 4 (2020): 1187. http://dx.doi.org/10.3390/w12041187.

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Reducing water use could impact existing sewer systems but this is not currently well understood. This work describes a new flow and wastewater quality model developed to investigate this impact. SIMDEUM WW® was used to generate stochastic appliance-specific discharge profiles for wastewater flow and concentration, which were fed into InfoWorks® ICM to quantify the impacts within the sewer network. The model was validated using measured field data from a sewer system in Amsterdam serving 418 households. Wastewater concentrations of total suspended solids (TSS), chemical oxygen demand (COD), to

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Abdul Wahab, Shafizi, Alia Aryssa Mohd Haris, Lay Ching Chai, et al. "Rapid Detection of Microbial Contamination on Food Contact Surfaces in Restaurants with Long Operating Hours using Mobile Flow Cytometer." Sains Malaysiana 54, no. 2 (2025): 473–81. https://doi.org/10.17576/jsm-2025-5402-13.

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Cross-contamination on food contact surfaces (FCS) increases the risk of foodborne diseases incidence. Traditional microbial detection methods are time-consuming, prompting the exploration of the rapid method; CytoQuant® mobile flow cytometer which employ perturbation of low-frequency electric fields between intact membrane and cytoplasm. The cross-sectional study used CytoQuant® and total plate count (TPC) involved 30 FCS from six (n = 6) selected restaurants with long operating hours in the Lembah Klang area. Findings showed that the CytoQuant® was able to detect the presence of microbial co

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Freitas Pedrosa, Simone Silveira de, Geraldo Magela Salomé, Paulo Roberto Maia, Matheus Henrique Lopes Dominguete, and José Dias da Silva Neto. "Dental Cavity Lining, Composite Resin and Bioceramic: Randomized Clinical Trial." International Journal of Innovative Research in Medical Science 7, no. 02 (2022): 79–85. http://dx.doi.org/10.23958/ijirms/vol07-i02/1357.

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Objective: Evaluation of postoperative sensitivity in posterior teeth restored with CIMMO DTA® liner, in composite resin restorations. Method: Randomized, double-blind clinical trial. There were 20 male participants, with an average age of 20 years. Totaling 70 treated teeth, divided into two groups: Group R (Control n=35), treated with standard restorative procedure. Group D (Study n=35), treated using CIMMO DTA® cement, as an indirect liner, the assessment was performed by a masked examiner. Sensitivity tests were performed before the restorative procedure, at 48 hours, 7, 15 and 30 days aft

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Endi Adriansyah and M. Syaiful. "Korelasi Suhu, pH, TSS Terhadap Pengukuran Parameter Besi Di Sumur Pantau TPA Dengan Minitab 17®." Jurnal Ilmiah Teknik dan Sains 2, no. 1 (2024): 20–24. http://dx.doi.org/10.62278/jits.v2i1.30.

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Lindi merupakan cairan akibat masuknya air hujan ke dalam sampah yang dapat membuat rembesan ke dalam air sumur atau perairan sekitar. Air lindi juga bisa merembes ke sumur di sekitar TPA. Pengukuran air di sumur pantau membutukan analisa secara laboratorium, dibutuhkan analisa yang cepat dan murah untuk mengukur air sumur pantau TPA. Pengukuran dapat dilakukan, seperti Suhu, pH, TSS, dan Besi. Penelitian ini menggunakan software Minitab 17®. Minitab 17® adalah aplikasi untuk menganalisis data statistik untuk menemukan hubungan antara parameter. Tujuan Penelitian ini mengetahui hubungan Suhu,

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Guadalupi, Marta, Alberto Maria Crovace, Donato Monopoli Forleo, Francesco Staffieri, and Luca Lacitignola. "Pressure-Sensitive Walkway System for Evaluation of Lameness in Dogs Affected by Unilateral Cranial Cruciate Ligament Rupture Treated with Porous Tibial Tuberosity Advancement." Veterinary Sciences 10, no. 12 (2023): 696. http://dx.doi.org/10.3390/vetsci10120696.

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The aim of this study was to objectively evaluate lameness in dogs affected by a unilateral cranial cruciate ligament rupture (CrCLR) treated with porous tibial tuberosity advancement before surgery and at three different timepoints after surgery, using the GAITRite® system (version 4.9Wr), a pressure-sensitive walkway system that is able to calculate several spatiotemporal gait parameters simultaneously for each limb. The dogs walked on the pressure-sensitive walkway before (T0) and 30 (T1), 90 (T2), and 120 (T3) days after surgery. Pressure measurements (gait lameness score and total pressur

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Kim, Jae Cheon, Eun Ji Park, and Dong Hee Na. "Gastrointestinal Permeation Enhancers for the Development of Oral Peptide Pharmaceuticals." Pharmaceuticals 15, no. 12 (2022): 1585. http://dx.doi.org/10.3390/ph15121585.

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Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have been developed and are considered as a breakthrough in peptide and protein drug delivery system development. In 2019, the Food and Drug Administration (FDA) approved an oral dosage form of semaglutide developed by Novo Nordisk (Rybelsus®) for the treatment of type 2 diabetes. Subsequently, the octreotide capsule (Mycapssa®), developed through Chiasma’s Transient Permeation Enhancer (TPE) technology, also received FDA approval in 2020 for the treatment of acromegaly. These two oral peptide products have be

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Dillon, Christian. "Abstract 6052: Systematic identification of novel targeted protein degradation mechanisms using SITESEEKER® technology." Cancer Research 84, no. 6_Supplement (2024): 6052. http://dx.doi.org/10.1158/1538-7445.am2024-6052.

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Abstract The rise of Targeted Protein Degradation (TPD) is rapidly changing perceptions about therapeutic target druggability and is rewriting many preconceived notions on drug design. However, the majority of monovalent molecular glue and heterobifunctional degraders in clinical and preclinical development rely predominantly on the recruitment of a single E3 ligase, Cereblon. Arising resistance, toxicities and restricted Protein-of-Interest scope may limit clinical potential, highlighting the need to uncover novel TPD mechanisms. To expand the potential of this modality, we have developed SIT

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Cenni, Elisabetta, Gabriela Ciapetti, Susanna Stea, Alessandro Di Leo, Daniela Cavedagna, and Arturo Pizzoferrato. "Functional Alterations of Endothelial Cells Cultured In Vitro in Contact with Biomaterials." Alternatives to Laboratory Animals 20, no. 1 (1992): 61–65. http://dx.doi.org/10.1177/026119299202000108.

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In order to evaluate in vitro the suitability of various prosthetic materials for endothelial seeding, human endothelial cells derived from the umbilical vein were placed in direct contact with a variety of polymers. As a control, endothelial cells were cultured in the absence of material. After 24, 48, 72 and 96 hours, the cells were counted and a viability test with neutral red was performed. Assays of 6-keto prostaglandinFla (6-keto-PGF1a), tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) were carried out on the supernatants. The cell counting technique demon

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Kicel, Agnieszka, and Monika Anna Olszewska. "Evaluation of Antioxidant Activity, and Quantitative Estimation of Flavonoids, Saponins and Phenols in Crude Extract and Dry Fractions of Medicago lupulina Aerial Parts." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000326.

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This study was designed to evaluate the flavonoid, saponin (TSC) and phenolic (TPC) contents and in vitro antioxidant activity of the crude (CME) and dry extracts and fractions of Medicago lupulina L. aerial parts. A validated RP-HPLC method led to quantitation of flavonols (kaempferol, quercetin and myricetin) and flavones (apigenin and luteolin) in the hydrolyzed extract. TSC and TPC were assayed spectrophotometrically at 560 and 760 nm, respectively. The antioxidant activity of the CME and the dry fractions were followed in vitro by DPPH free radical and ferric reducing antioxidant power (F

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Nasrallah, Gheyath K., Raniya Al-Buainain, Nadin Younes, et al. "Screening and diagnostic testing protocols for HIV and Syphilis infections in health care setting in Qatar: Evaluation and recommendations." PLOS ONE 18, no. 2 (2023): e0278079. http://dx.doi.org/10.1371/journal.pone.0278079.

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Background HIV and Syphilis are common STIs, which have become a concern and burden on healthcare systems, as many infections go untreated and lead to potentially serious complications. HIV is usually diagnosed with Western blot, PCR, and p24 antigen testing. Whereas, Syphilis is mainly diagnosed through clinical findings and serologic testing. The Medical Commission Department (MC) under MOPH is responsible for screening all newcomers to Qatar, aiming to keep the country free from serious infectious diseases. Objective We aimed to evaluate the diagnostic efficiency of the protocols used in th

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Endi Adriansyah, Monik Kasman, Ira Galih Prabasari, and Edwin Permana. "Korelasi parameter pencemar fisika dan mikrobiologi dalam leachate dengan response surface methodology." Jurnal Teknik Kimia 25, no. 3 (2019): 86–89. http://dx.doi.org/10.36706/jtk.v25i3.132.

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Leachate adalah cairan yang ditimbulkan oleh sampah akibat masuknya air eksternal yang dapat melarutkan materi-materi terlarut. Analisis parameter dalam leachate memerlukan analisis khusus maka diperlukan suatu kegiatan monitoring sederhana terhadap kualitas leachate yang dihasilkan oleh suatu TPA. Kegiatan monitoring dapat dilakukan dengan melakukan pengukuran terhadap parameter fisika, kimia dalam leachate. Response Surface Methodology di dalam penelitian ini menggunakan Minitab® 17. Minitab® 17 adalah salah satu program komputer yang dirancang untuk melakukan pengolahan statistik. Hal ini m

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Tsuchiya, Yasuo, Sergio Baez, Alfonso Calvo, et al. "Evidence that Genetic Variants of Metabolic Detoxication and Cell Cycle Control Are Not Related to Gallbladder Cancer Risk in Chilean Women." International Journal of Biological Markers 25, no. 2 (2010): 75–78. http://dx.doi.org/10.1177/172460081002500203.

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Background and aims High consumption of red chili pepper has been shown to be a risk factor for gallbladder cancer (GBC) in Chilean women. However, genetic factors in addition to this and other environmental factors may also be associated with an increased risk of GBC. We aimed to examine the associations of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumor protein p53 (TP53) polymorphisms with the risk of GBC in Chilean women. Methods A hospital-based case-control study of 57 patients with GBC, 119 patients with gallstones, and 70 controls was conducted. The

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Li, Cong-Jun, and Robert W. Li. "Bioinformatic Dissecting of TP53 Regulation Pathway Underlying Butyrate-induced Histone Modification in Epigenetic Regulation." Genetics & Epigenetics 6 (January 2014): GEG.S14176. http://dx.doi.org/10.4137/geg.s14176.

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Butyrate affects cell proliferation, differentiation, and motility. Butyrate inhibits histone deacetylase (HDAC) activities and induces cell-cycle arrest and apoptosis. TP53 is one of the most active upstream regulators discovered by ingenuity pathways analysis (IPA) in our RNA-sequencing data set. TP53 signaling pathway plays key role in many cellular processes. TP53 pathway and their involvement in cellular functions modified by butyrate treatment were scrutinized in this report by data mining the RNA-sequencing data using IPA (Ingenuity System®). The TP53 mechanistic pathway targets more th

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Makkiya, Nisreen Mazin, and Israa Abdul wahab Al-baldawi. "Biodegradation of Total Petroleum Hydrocarbon from Al-Daura Refinery Wastewater by Rhizobacteria." Journal of Engineering 26, no. 1 (2019): 14–23. http://dx.doi.org/10.31026/j.eng.2020.01.02.

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Due to the deliberate disposal of industrial waste, a great amount of petroleum hydrocarbons pollute the soil and aquatic environments. Bioremediation that depends on the microorganisms in the removal of pollutants is more efficient and cost-effective technology. In this study, five rhizobacteria were isolated from Phragmites australis roots and exposed to real wastewater from Al-Daura refinery with 70 mg/L total petroleum hydrocarbons (TPH) concentration. The five selected rhizobacteria were examined in a biodegradation test for seven days to remove TPH. The results showed that 80% TPH degrad

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Schär, Matthias, Lucian Zweifel, Delal Arslan, Stefan Grieder, Christoph Maurer, and Christian Brauner. "Fused Filament Fabrication of Bio-Based Polyether-Block-Amide Polymers (PEBAX) and Their Related Properties." Polymers 14, no. 23 (2022): 5092. http://dx.doi.org/10.3390/polym14235092.

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This paper describes the application of poly(ether-block-amide) polymers, so-called Pebax, in fused filament fabrication (FFF). Pebax® is a thermoplastic elastomer (TPE), a copolymer based on rigid polyamide and soft polyether blocks. By variation of the blocks, unique properties such as soft or rigid behaviour are tailored without additional additives and plasticisers. Pebax®Rnew® polyamide blocks are bio-based and made from castor beans that allow the design of sustainable applications. In this study, two types of Pebax were selected, processing parameters were characterised, filaments were

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Sánchez-Matiz, Juan José, Hair Santiago Lozano-Puentes, David A. Villamarín-Raad, Sergio A. Díaz-Gallo, and Lucía Ana Díaz-Ariza. "Dynamic of Phenolic Compounds in Guadua angustifolia Kunth under Chemical, Organic, and Biological Fertilization." Agronomy 13, no. 11 (2023): 2782. http://dx.doi.org/10.3390/agronomy13112782.

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Guadua angustifolia produces phenolic compounds, and this production may be influenced by the application of chemical, organic, and biological fertilizers. Currently, the effect of such fertilizers on the synthesis dynamics of this group of metabolites in bamboo is unknown. In this study, the total phenolic content (TPC) and total flavonoid content (TFC) in the leaves of plants fertilized with diammonium phosphate (DAP) and humus in combination with the biofertilizers Promofort®, Azospirillum brasilense, Pseudomonas fluorescens, and Stenotrophomonas sp. were determined using colorimetric techn

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Bhudolia, Somen K., Goram Gohel, Durga Vasudevan, Kah Fai Leong, and Pierre Gerard. "Behaviour of Rectangular Hollow Thin Ply Carbon Thermoset and Thermoplastic Composite Tubes Subjected to Bending." Polymers 14, no. 7 (2022): 1386. http://dx.doi.org/10.3390/polym14071386.

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Tubular composites are widely used in many industrial applications, and there is need to use new material and reliable manufacturing processes to improve the performance and process aspects. The current research presents a detailed study to understand the flexure response of rectangular tubular composites based on thin ply carbon fibres and Elium® resin. Another aim was to understand the failure mechanisms of novel tubular thermoplastic composite systems and carry out a baseline comparison with Epoxy-based tubular systems. In the current research, a bladder-assisted resin transfer moulding pro

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Zahid, Hafza Fasiha, Chaminda Senaka Ranadheera, Zhongxiang Fang, and Said Ajlouni. "Functional and Healthy Yogurts Fortified with Probiotics and Fruit Peel Powders." Fermentation 8, no. 9 (2022): 469. http://dx.doi.org/10.3390/fermentation8090469.

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The application of processing waste by-products along with probiotics is an interesting choice to confer potential functional aspects to food products. This study was designed to investigate the nutritional capacity of freeze-dried mango peel powder (MPP) and banana peel powder (BPP) in the presence of a mixture of three probiotic species (1% of each of three probiotics (Lacticaseibacillus casei (431®), Lacticaseibacillus rhamnosus (LGG®) and Bifidobacterium subsp. Lactis (Bb-12®)) as sources of additional nutrients and prebiotics in fresh and rehydrated freeze-dried (RFD) yogurts for 28 days

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Horta, André, Ana M. Duarte, Sónia Barroso, et al. "Extraction of Antioxidants from Brown Macroalgae Fucus spiralis." Molecules 29, no. 10 (2024): 2271. http://dx.doi.org/10.3390/molecules29102271.

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In this study, different extraction methods and conditions were used for the extraction of antioxidants from brown macroalgae Fucus spiralis. The extraction methodologies used were ultrasound-assisted extraction (ultrasonic bath and ultrasonic probe), extraction with a vortex, extraction with an Ultra-Turrax® homogenizer, and high-pressure-assisted extraction. The extracts were analyzed for their total phenolic content (TPC) and their antioxidant activity, and evaluated through the 2,2-difenil-1-picrilhidrazil (DPPH) free radical scavenging method and ferric reducing antioxidant power (FRAP) a

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Pinto, Regina, and Fernando Schmitt. "A Real-World Study Reporting the Use of Foundation Medicine® Testing in Portugal." Journal of Molecular Pathology 4, no. 3 (2023): 156–65. http://dx.doi.org/10.3390/jmp4030014.

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Foundation Medicine® testing is a next-generation sequence (NGS)-based platform that allows clinicians to obtain the comprehensive genomic profiling (CGP) of several cancers. By using NGS approaches, relevant genomic alterations can be identified in a short timeframe, providing guidance to diagnostic and therapeutic decisions. This study reports the implementation of three commercially available Foundation Medicine® tests in a Portuguese institution and explores the genomic alterations identified. Data obtained from 72 patients tested with Foundation Medicine® between July 2017 and December 20

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El Kantar, Sally, Hiba N. Rajha, André El Khoury, et al. "Phenolic Compounds Recovery from Blood Orange Peels Using a Novel Green Infrared Technology Ired-Irrad®, and Their Effect on the Inhibition of Aspergillus flavus Proliferation and Aflatoxin B1 Production." Molecules 27, no. 22 (2022): 8061. http://dx.doi.org/10.3390/molecules27228061.

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The intensification of total phenolic compound (TPC) extraction from blood orange peels was optimized using a novel green infrared-assisted extraction technique (IRAE, Ired-Irrad®) and compared to the conventional extraction using a water bath (WB). Response surface methodology (RSM) allowed for the optimization of ethanol concentration (E), time (t), and temperature (T) in terms of extracted TPC and their antiradical activity, for both WB extraction and IRAE. Using WB extraction, the multiple response optimums as obtained after 4 h at 73 °C and using 79% ethanol/water were 1.67 g GAE/100 g fo

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Scheipl, Susanne, Iva Brcic, Tina Moser, et al. "Molecular profiling of soft-tissue sarcomas with FoundationOne® Heme identifies potential targets for sarcoma therapy: a single-centre experience." Therapeutic Advances in Medical Oncology 13 (January 2021): 175883592110291. http://dx.doi.org/10.1177/17588359211029125.

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Background: Molecular diagnosis has become an established tool in the characterisation of adult soft-tissue sarcomas (STS). FoundationOne® Heme analyses somatic gene alterations in sarcomas via DNA and RNA-hotspot sequencing of tumour-associated genes. Methods: We evaluated FoundationOne® Heme testing in 81 localised STS including 35 translocation-associated and 46 complex-karyotyped cases from a single institution. Results: Although FoundationOne® Heme achieved broad patient coverage and identified at least five genetic alterations in each sample, the sensitivity for fusion detection was rath

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Mohammadi, Farzad, Nicolas Bertrand, and Iwona Rudkowska. "C57bl/6 Mice Show Equivalent Taste Preferences toward Ruminant and Industrial Trans Fatty Acids." Nutrients 15, no. 3 (2023): 610. http://dx.doi.org/10.3390/nu15030610.

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Two distinct types of trans fatty acids (TFA) are found in the diet. Industrial TFA such as elaidic acid (EA) have deleterious effects on metabolic risk factors, and oppositely ruminant TFA including trans-palmitoleic acid (TPA) may have beneficial effects. The objective is to evaluate the taste preference between EA, TPA, lecithin or water. In this study, 24 female C57BL/6 mice were microchipped and placed in two separate IntelliCages®. Nano encapsulated TFA or lecithin were added to drinking water in different corners of the cage with normal diet. The study was carried out over 5 weeks, duri

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Jha, Dinesh Kumar, Luis Javier Martinez Gonzalez, Jiwan Prasad Rijal, Bhinu Shova Tuladhar, and Nirajan Thapa Chhetri. "Allele Frequencies of 15 AmpFISTR Identifiler loci in the Nepalese population." Scientific World 10, no. 10 (2012): 20–23. http://dx.doi.org/10.3126/sw.v10i10.6856.

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Allele frequencies for the 15 STR loci in the AmpFlSTR® Identifiler® and statistical parameters were estimated from a sample of 233 unrelated individuals from different area of Nepal. A total of 161 alleles were found, with corresponding allelic frequencies ranging from 0.0021 to 0.4077. The MP, PD, PIC, PE, TPI, Ho and He ranged from 0.0282 to 0.1511, 0.8489 to 0.9717, 0.6478 to 0.8700, 0.4546 to 0.7631, 1.7651 to 4.3148, 0.7167 to 0.8841 and 0.7009 to 0.8833 respectively. Deviations from the Hardy–Weinberg Equilibrium were observed for D16S539, D18S51, D21S11 and TPOX Markers. One new allele

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Emeje, Martins, Lucy John-Africa, Yetunde Isimi, Olobayo Kunle, and Sabinus Ofoefule. "Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline." Acta Pharmaceutica 62, no. 1 (2012): 71–82. http://dx.doi.org/10.2478/v10007-012-0001-6.

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Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline Sustained release (SR) dosage forms enable prolonged and continuous deposition of the drug in the gastrointestinal (GI) tract and improve the bioavailability of medications characterized by a narrow absorption window. In this study, a new strategy is proposed for the development of SR dosage forms for theophylline (TPH). Design of the delivery system was based on a sustained release formulation, with a modified coating technique and swelling features aimed to extend the release time of the drug. Diff

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Pagès, Geoffrey, Meike Hammer, Jean-Guillaume Grand, and Iban Irubetagoyena. "Long-term outcome of tibial plateau leveling osteotomy using an antimicrobial silver-based coated plate in dogs." PLOS ONE 17, no. 8 (2022): e0272555. http://dx.doi.org/10.1371/journal.pone.0272555.

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Objectives To evaluate long-term outcome using the BioMedtrix™ TPLO Curve® plate in dogs with cranial cruciate ligament disease (CrCLd) treated by tibial plateau leveling osteotomy (TPLO). Study design Retrospective case study. Animals Dogs (n = 323, 337 stifles). Methods Medical records were searched for dogs presented with CrCLd and treated by TPLO with the BioMedtrix™ TPLO Curve® plate for 3.5 mm screws between March 2018 and December 2020. Tibial plateau angles (TPA) were measured on preoperative, postoperative, and follow-up radiographs. Changes in TPA between postoperative and follow-up

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Singh, Kuldeep, Qing Zhao Ruan, Jonathan Schor, Garry Lachhar, Sumit Saha, and Jonathan Deitch. "Thigh Compartment Syndrome After Thrombolytic Therapy of an Occluded Lower Extremity Bypass Graft." Vascular and Endovascular Surgery 54, no. 8 (2020): 752–55. http://dx.doi.org/10.1177/1538574420947855.

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Compartment syndrome is caused by increased pressure within fascial compartment. We present a unique case of a thigh compartment syndrome that occurred after overnight catheter delivered Tissue plasminogen activator (tPA) thrombolysis of an acutely thrombosis femoral-to above knee popliteal artery Propaten® PTFE (WL Gore & Associates, Flagstaff, AZ) bypass graft. The condition was treated by emergency fasciotomy and the patient recovered uneventfully.

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Yu, Shuhao, Dennis L. Martin, Justin Q. Moss, and Yanqi Wu. "Advanced Turf-type Bermudagrass Experimental Genotypes Show Marked Variation in Drought Response." HortScience 58, no. 6 (2023): 600–607. http://dx.doi.org/10.21273/hortsci17085-23.

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Bermudagrass (Cynodon sp.) is one of the most commonly used warm-season turfgrasses in the southern areas and transition zone of the United States. Due to the increasing demand for water resources and periodic drought, it is important to improve the drought resistance of bermudagrass for water savings and persistence under drought stress. This study was conducted to determine whether experimental bermudagrass genotypes have improved drought resistance compared with the standard cultivars Tifway and Riley’s Super Sport (Celebration®) at Stillwater, OK. The trials were designed as randomized com

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Giordano, Maria, Christophe El-Nakhel, Petronia Carillo, et al. "Plant-Derived Biostimulants Differentially Modulate Primary and Secondary Metabolites and Improve the Yield Potential of Red and Green Lettuce Cultivars." Agronomy 12, no. 6 (2022): 1361. http://dx.doi.org/10.3390/agronomy12061361.

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The use of biostimulants in modern agriculture has rapidly expanded in recent years, owing to their beneficial effects on crop yield and product quality, which have come under the scope of intensive research. Accordingly, in the present study we appraised the efficacy of two plant-derived biostimulants, the legume-derived protein hydrolysates Trainer®® (PH), and the tropical plant extract Auxym®® (TPE) on two lettuce cultivars (green and red salanova®®) in terms of morpho-physiological and biochemical traits (primary and secondary metabolites). The two cultivars differed in their acquisition c

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Ward, Laura Sterian, Larissa Teodoro Rabi, Elisângela de Souza Teixeira, et al. "ODP272 ROUNDUP IS AN IMPORTANT DISRUPTOR THAT CAUSES PROLIFERATIVE EFFECTS ON NORMAL AND ON CANCER THYROID CELLS." Journal of the Endocrine Society 6, Supplement_1 (2022): A433—A434. http://dx.doi.org/10.1210/jendso/bvac150.901.

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Abstract Glyphosate has long be suspected to promote endocrine disruptive and even carcinogenic effects, but little is known about its effect at different concentrations on normal and on cancer thyroid cells. Since the endocrine system responds to low chemical concentrations and abnormal cells may have different sensitivity, it is essential to determine the effects of this compound at different levels, including the Acceptable Occupational Exposure Level (AOEL) and the Acceptable Daily Intake (IDA) doses. We used two human thyroid-derived cell lines strains, Nthy-ori 3-1 (from thyroid normal f

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Janssens, Michiel Etienne, and Stuart Wakelin. "Centrifugal and Membrane Therapeutic Plasma Exchange – A Mini-review." European Oncology & Haematology 14, no. 2 (2018): 105. http://dx.doi.org/10.17925/eoh.2018.14.2.105.

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During therapeutic plasma exchange (TPE), a large volume of a patient’s plasma is separated from the cellular components of the blood and replaced with appropriate fluids to remove circulating plasma components and disease mediators such as antibodies, cholesterol, toxins and drugs. Automated TPE systems can be categorised into two distinct groups based on the method of plasma separation: centrifugal TPE (cTPE) and membrane filtration TPE (mTPE). While technical and performance parameters for various TPE systems have been reported previously, the recent publication of several head-to-head stud

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Yang, Yang, and Yang Li. "Improvement of Packaging Structure and Materials about Daily Chemical Products Plastic Hose Packaging." Advanced Materials Research 690-693 (May 2013): 3406–9. http://dx.doi.org/10.4028/www.scientific.net/amr.690-693.3406.

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Because of a waste problem in plastic hose packaging of daily chemical products, this article recommends an improvement to the structure and material of packaging design for these products. Through the use of a Ziploc®-type structure, this re-design achieves the needs for making full use of package contents and for package reloading functionality. TPE rubber replaces traditional PE plastic, making the improved structure more reasonable to produce, while promoting environmental protection.

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Di Mola, Ida, Eugenio Cozzolino, Lucia Ottaiano, et al. "Effect of Vegetal- and Seaweed Extract-Based Biostimulants on Agronomical and Leaf Quality Traits of Plastic Tunnel-Grown Baby Lettuce under Four Regimes of Nitrogen Fertilization." Agronomy 9, no. 10 (2019): 571. http://dx.doi.org/10.3390/agronomy9100571.

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Nitrogen (N) fertilizers play a crucial role in agriculture, representing a powerful tool for farmers for increasing yields throughout the seasons under both optimal and suboptimal conditions. At the same time, their synthetic/chemical nature could have several influences on ecosystems and human health. For this reason, there is an urgent need to find new and more sustainable means of production to increase plant productivity and optimize nitrogen use. An experiment was conducted in a plastic tunnel to assess the response of baby lettuce crop to the foliar application of three plant biostimula

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Nova, Paulo, Sara A. Cunha, Ana R. Costa-Pinto, and Ana Maria Gomes. "Chemical and Antioxidant Properties of Solvent and Enzyme-Assisted Extracts of Fucus vesiculosus and Porphyra dioica." Marine Drugs 22, no. 7 (2024): 319. http://dx.doi.org/10.3390/md22070319.

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Extraction strategies impact the efficiency and nature of extracted compounds. This work assessed the chemical composition and antioxidant capacity of ethanolic, hydroethanolic, and aqueous versus enzyme-assisted extracts (isolated or with the sequential use of alcalase®, cellulase®, and viscozyme®) of the macroalgae Fucus vesiculosus (brown, Phaeophyceae) and Porphyra dioica (red, Rhodophyta. For both macroalgae, enzyme-assisted extraction (EAE) was the most efficient process compared to solvent-assisted extraction (SAE), independent of solvent. Fucus vesiculosus extraction yields were higher

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Hognert, Helena, Bachar Ghanoum, Helena Gustafsson, Ian Milsom та Karin Manhem. "Acute Effects of Transdermal 17β-Estradiol on Hemostatic Variables after 24-hour Treatment". Clinical and Applied Thrombosis/Hemostasis 8, № 3 (2002): 239–43. http://dx.doi.org/10.1177/107602960200800307.

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The aim of this study was to investigate the acute effects of transdermal 17β-estradiol (Estraderm®) on plasma levels of coagulatory and fibrinolytic factors in postmenopausal normotensive and hypertensive women. Eleven normotensive and 13 hypertensive women were included in this placebo-controlled crossover study. In a randomized order each subject was treated with a patch of 100 yig 17β-estradiol or placebo for 24 hours. Serum levels of tissue type plasminogen activator (tPA) activity, plasminogen activator inhibitor I (PAI-1) activity, tPA antigen, PAI-I antigen, FVII, FX, and fibrinogen we

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Yen, Dang Thi Kim, and Nguyen Vu Hong Ha. "Effects of maturity stages and fermentation of cocoa beans on total phenolic contents and antioxidant capacities in raw cocoa powder." Vietnam Journal of Biotechnology 14, no. 4 (2018): 743–52. http://dx.doi.org/10.15625/1811-4989/14/4/12309.

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Consumption of cocoa (Theobroma cacao L.) and cocoa products is associated with numerous health benefits due to their high levels of polyphenols and antioxidant capacities. In this study, changes of total phenolic contents (TPC) and antioxidant capacities (AC) of raw cocoa powder at four maturity stages, under different fermentation methods and fermentation duration of cocoa beans were investigated. The TPC and AC were measured using Folin–Ciocalteu and Trolox equivalent antioxidant capacity (TEAC)/ABTS assay, respectively. In term of maturity stages, the powder of unfermented cocoa beans harv

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Dempfle, C. E., S. A. Pfitzner, M. Dollman, K. Huck, G. Stehle, and D. L. Heene. "Comparison of Immunological and Functional Assays for Measurement of Soluble Fibrin." Thrombosis and Haemostasis 74, no. 02 (1995): 673–79. http://dx.doi.org/10.1055/s-0038-1649796.

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SummaryVarious assays have been developed for quantitation of soluble fibrin or fibrin monomer in clinical plasma samples, since this parameter directly reflects in vivo thrombin action on fibrinogen. Using plasma samples from healthy blood donors, patients with cerebral ischemic insult, patients with septicemia, and patients with venous thrombosis, we compared two immunologic tests using monoclonal antibodies against fibrin-specific neo-epitopes, and two functional tests based on the cofactor activity of soluble fibrin complexes in tPA-induced plasminogen activation. Test A (Enzymun®-Test FM)

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Helbig, Stefanie, and J. Corinna Eule. "Evaluation des Applanationstonometers Tono-Pen Avia® Vet™ für die Bestimmung des Augeninnendrucks bei Hunden und Katzen." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 49, no. 02 (2021): 86–92. http://dx.doi.org/10.1055/a-1197-4709.

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Zusammenfassung Gegenstand und Ziel Tonometer messen den Augeninnendruck (IOD) nur indirekt, sodass es zu Messungenauigkeiten kommt. Alle Geräte müssen daher durch vergleichende manometrische Messungen für die einzelnen Tierarten kalibriert werden. Im Rahmen dieser Studie wurde das Applanationstonometer Tono-Pen Avia® Vet™ (TPA) für Hund und Katze kalibriert und ein Korrekturfaktor berechnet. Anschließend wurden anhand einer augengesunden Population Referenzwerte bestimmt und der Einfluss von Alter, Körpergewicht und Geschlecht untersucht. Material und Methoden Für die manometrische Studie erf

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Zátroch, István, Anikó Smudla, Barna Babik, et al. "Procoagulatio, hypercoagulatio és fibrinolysis „shut down” kimutatása ClotPro® viszkoelasztikus tesztek segítségével COVID–19-betegekben." Orvosi Hetilap 161, no. 22 (2020): 899–907. http://dx.doi.org/10.1556/650.2020.31870.

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Absztrakt: Bevezetés: Nemzetközi tapasztalatok alapján a COVID–19-fertőzött, kórházban kezelt betegek több mint 30%-ában vénás, artériás és microvascularis thrombosis, disszeminált intravascularis véralvadási zavar, illetve thromboembolia alakul ki. Ennek laboratóriumi jellemzői a magas D-dimer- és fibrinogénszint, valamint a megnyúlt prothrombinidő és aktivált parciális thromboplastinidő. Módszer: Az esetbemutatások során intenzív osztályon kezelt, COVID–19-fertőzött betegek (n = 3) ClotPro® trombolasztométeres (EX-test, IN-test, FIB-test, RVV-test és TPA-test) eredményeit értékeltük a klinik

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Widijanto, Utami, Trilaksana Nugroho, and Maharani Cahyono. "Effect Of Topical DLBS 1425 On Tissue Plasminogen Activator (tPA) Expression In Trabecular Meshwork Of Wistar Rats." Medica Hospitalia : Journal of Clinical Medicine 8, no. 1 (2021): 15–20. http://dx.doi.org/10.36408/mhjcm.v8i1.553.

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Introduction: Tissue plasminogen activator (tPA) in the trabecular meshwork (TM) is a serine protease that important to maintain the aquos outflow resistance by activating the matrix metalloproteinase (MMP). It can cause a degradation of the extracellular matrix, which can maintain the normal flow of aquos humor. However, the use of anti-inflammatory drugs has been shown to reduce the expression of tPA, leading to an increase in the outflow resistance. Therefore, we propose the use of DLBS 1425, an extract of Phaleria macrocarpa which has been proven to have anti-inflammatory effects. Ai

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