Relevant bibliographies by topics / Tp20

Academic literature on the topic 'Tp20'

Author: Grafiati
Published: 26 July 2024

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Journal articles on the topic "Tp20"

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Devaquet, Jérôme, Björn Jonson, Lisbet Niklason, Anne-Gaëlle Si Larbi, Leif Uttman, Jérôme Aboab, and Laurent Brochard. "Effects of inspiratory pause on CO2 elimination and arterial Pco2 in acute lung injury." Journal of Applied Physiology 105, no. 6 (December 2008): 1944–49. http://dx.doi.org/10.1152/japplphysiol.90682.2008.

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A high respiratory rate associated with the use of small tidal volumes, recommended for acute lung injury (ALI), shortens time for gas diffusion in the alveoli. This may decrease CO2 elimination. We hypothesized that a postinspiratory pause could enhance CO2 elimination and reduce PaCO2 by reducing dead space in ALI. In 15 mechanically ventilated patients with ALI and hypercapnia, a 20% postinspiratory pause (Tp20) was applied during a period of 30 min between two ventilation periods without postinspiratory pause (Tp0). Other parameters were kept unchanged. The single breath test for CO2 was recorded every 5 min to measure tidal CO2 elimination (VtCO2), airway dead space (VDaw), and slope of the alveolar plateau. PaO2, PaCO2, and physiological and alveolar dead space (VDphys, VDalv) were determined at the end of each 30-min period. The postinspiratory pause, 0.7 ± 0.2 s, induced on average <0.5 cmH2O of intrinsic positive end-expiratory pressure (PEEP). During Tp20, VtCO2 increased immediately by 28 ± 10% (14 ± 5 ml per breath compared with 11 ± 4 for Tp0) and then decreased without reaching the initial value within 30 min. The addition of a postinspiratory pause significantly decreased VDaw by 14% and VDphys by 11% with no change in VDalv. During Tp20, the slope of the alveolar plateau initially fell to 65 ± 10% of baseline value and continued to decrease. Tp20 induced a 10 ± 3% decrease in PaCO2 at 30 min (from 55 ± 10 to 49 ± 9 mmHg, P < 0.001) with no significant variation in PaO2. Postinspiratory pause has a significant influence on CO2 elimination when small tidal volumes are used during mechanical ventilation for ALI.
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Komárková, Martina, Jakub Chromý, Eva Pokorná, Petr Soudek, and Pavlína Máchová. "Physiological and Transcriptomic Response of Grey Poplar (Populus ×canescens Aiton Sm.) to Cadmium Stress." Plants 9, no. 11 (November 4, 2020): 1485. http://dx.doi.org/10.3390/plants9111485.

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(1) Background: Populus ×canescens (Aiton) Sm. is a fast-growing woody plant belonging to the family Salicaceae. Two poplar genotypes characterized by unique phenotypic traits (TP11 and TP20) were chosen to be characterized and tested for a physiological and transcriptomic response to Cd stress. (2) Methods: A comparative analysis of the effects of exposure to high cadmium (Cd) concentrations (10 µM and 100 µM) of TP11 and TP20 was performed. (3) Results: Neither of the tested Cd concentration negatively affected plant growth; however, the chlorophyll content significantly decreased. The potassium (K) content was higher in the shoots than in the roots. The magnesium concentrations were only slightly affected by Cd treatment. The zinc content in the shoots of TP20 was lower than that in the shoots of TP11. Cd accumulation was higher in the roots than in the shoots. After 10 days of exposure, 10 µM Cd resulted in comparable amounts of Cd in the roots and shoots of TP20. The most significant change in transcript amount was observed in endochitinase 2, 12-oxophytodienoate reductase 1 and phi classglutathione S-transferase. (4) Conclusions: Our study provided new insights for effective assessing the ability of different poplar genotypes to tolerate Cd stress and underlying Cd tolerance.
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Schmid, R. A., S. Hillinger, J. Hamacher, and U. Stammberger. "TP20 is superior to TP10 in reducing ischemia/reperfusion injury in rat lung grafts." Transplantation Proceedings 33, no. 1-2 (February 2001): 948–49. http://dx.doi.org/10.1016/s0041-1345(00)02279-x.

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P. Hardy, Matthew, Tony Rowe, and Sandra Wymann. "Soluble Complement Receptor 1 Therapeutics." Journal of Immunological Sciences 6, no. 4 (October 21, 2022): 1–17. http://dx.doi.org/10.29245/2578-3009/2022/4.1240.

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Human Complement Receptor 1 (CR1/CD35) is a potent negative regulator of the complement system. Its mechanism of action is through interaction with the complement activation fragments, C3b and C4b to mediate decay acceleration of the C3 and C5 convertase complexes as well as cleavage of both ligands into inactive fragments via cofactor activity. The result is inhibition of the classical, lectin, and alternative complement pathways. This article will focus on recombinant soluble forms of CR1 that have been generated as potential therapeutics for complement-mediated disorders. Specifically, we will review and contrast the in vitro and in vivo properties of: sCR1 (BRL55730/TP10/CDX-1135), the soluble full-length extracellular domain of human CR1; sCR1-sLex (TP20), a glyco-engineered version of sCR1 additionally targeted to activated endothelium; APT070 (Mirococept), a CR1 fragment conjugated to a myristoylated peptide to enhance tissue targeting; and CSL040, a soluble truncated version of the CR1 extracellular domain which exhibits altered potency and pharmacokinetic properties as compared to the parental molecule. The data obtained from studies on the effects of these CR1-based molecules in animal models of disease and their therapeutic applications will also be discussed.
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Stajić, Slaviša, Patrycja Skwarek, Sanja Đurđević, Małgorzata Karwowska, Boris Pisinov, Igor Tomasevic, and Vladimir Kurćubić. "Tomato Pomace Powder as a Functional Ingredient in Minced Meat Products—Influence on Technological and Sensory Properties of Traditional Serbian Minced Meat Product Ćevapi." Processes 12, no. 7 (June 27, 2024): 1330. http://dx.doi.org/10.3390/pr12071330.

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The aim of this research is to evaluate the impact of tomato pomace (TP) on the technological and sensory properties of ćevapi. Four treatments were prepared as follows: control (CON) and samples with the addition of TP in amounts of TP5 (0.5%—5 g/kg), TP10 (1%—10 g/kg), and TP20 (2%—20 g/kg). Technological properties (pH values, water activity (aw) cooking loss, length reduction), instrumental colour and texture, and sensory properties were examined. The addition of TP powder did not result in significant differences in pH and aw values between CON and modified treatments (in both raw and grilled). The addition of TP in the amounts higher than 10 g/kg significantly reduced cooking loss, while length reduction was observed when 20 g/kg was added. Also, significantly higher values of yellowness were observed in both the raw and grilled ćevapi, when 10 g/kg and more of TP was added. Significantly higher hardness and chewiness were observed in all experimental treatments. However, differences in instrumental colour and texture were not negatively perceived by the assessors, and there were no significant differences in any observed sensory properties between the CON and experimental treatments. Moreover, all the experimental treatments received a relatively high mark of around seven and higher on a nine-point hedonic scale. Further research could focus on the examination of salt/meat reduction as well as oxidative stability during freeze storage.
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Gulay, Lubomir D., and Dariusz Kaczorowski. "Crystal structure and low-temperature magnetic properties of R2Au2Pb (R = Y, La–Nd, Sm, Gd–Lu) plumbides." Low Temperature Physics 49, no. 3 (March 2023): 338–44. http://dx.doi.org/10.1063/10.0017237.

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Polycrystalline samples of the ternary compounds R2Au2Pb (R = Y, La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) were studied by means of powder X-ray diffraction and magnetic measurements. All these materials were found to crystallize with a tetragonal crystal structure of the Er2Au2Sn type (space group P42 /mnm, Pearson code tP20). The Y-, La-, and Lu-based phases were established to be diamagnetic, while Yb2Au2Pb was characterized as an intermediate valence system due to an unstable 4 f shell. All the other R2Au2Pb ternaries were found to order antiferromagnetically at low temperatures ( TN in the range 2–30 K) due to the localized magnetic moments carried on trivalent R3+ ions.
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Zaidi, Syeda Huma Haider, Abida Ash Mohd, Mohd Imran, Menwah Khalifah Alshammari, and Khattab Fahed Alfrah. "Design, In Silico Studies, and Synthesis of Some Azole Derivatives as Antimicrobial Agents." Oriental Journal Of Chemistry 39, no. 6 (December 27, 2023): 1579–88. http://dx.doi.org/10.13005/ojc/390618.

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This work relates to the discovery of safer and more potent triazole-pyridazinone hybrid (TP) compounds as an inhibitor of sterol 14α-demethylase (SDM). The chemical structures of thirty-three TPs (TP1 to TP33) were designed. The docking scores (DS) of TPs were determined by molecular docking software utilizing three different proteins of SDM (PDB IDs: 3LD6, 5FSA, and 5TZ1). The ProTox II web server predicted TPs' oral LD50 and toxicity class (TC), whereas the Swiss-ADME database anticipated their pharmacokinetic parameters. Based on the in silico study data, four TPs (TP18, TP22, TP27, and TP33) were synthesized and evaluated for their in vitro antifungal activity against seven fungi. The DS (kcal/mol) of TP18 (3LD6 = -8.27; 5FSA = -9.07; 5TZ1 = -9.42), TP22 (3LD6 = -8.23; 5FSA = -8.93; 5TZ1 = -9.57), TP27 (3LD6 = -8.31; 5FSA = -9.12; 5TZ1 = -9.38), and TP33 (3LD6 = -8.19; 5FSA = -8.98; 5TZ1 = -9.94) were better than the DS of fluconazole (3LD6 = -8.18; 5FSA = -8.79; 5TZ1 = -9.18) and ketoconazole (3LD6 = -8.16; 5FSA = -8.86; 5TZ1 = -9.06) implying high potency of TP18, TP22, TP27 and TP33 than fluconazole and ketoconazole against SDM. The anticipated LD50 and toxicity class (TC) of TP18 (500 mg/kg; TC 4), TP22 (500 mg/kg; TC 4), TP27 (1000 mg/kg; TC 4), and TP33 (1000 mg/kg; TC 4) was better than ketoconazole (166 mg/kg; TC 3). The Swiss-ADME database results revealed that TP18, TP22, TP27, and TP33 passed Lipinski’s drug-likeliness rule and demonstrated high oral absorption and bioavailability comparable to ketoconazole and fluconazole. The synthesized compounds' spectral data (FTIR, 1H-NMR, 13C-NMR, and Mass) aligned to their designed chemical structure. The antifungal activity data implies that TP18, TP22, TP27, and TP33 were better antifungal agents than fluconazole and ketoconazole against tested fungi. These findings concurred with the DS of TP18, TP22, TP27, and TP33. In conclusion, TP18, TP22, TP27, and TP33 represent a new chemical template for developing safer and better SDM inhibitors as antifungal agents.
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Phuong, Nguyen Van, Nguyen Thuy Linh, Trinh Dinh Duy, Tran Le Nam Khanh, Do Doan Thu Giang, Ta Thi Thuy Linh, Mai Thi Phuong Nga, et al. "Identification and evaluation of enzymes gelatinase, amylase, and catalase produced by rice root endophytic bacteria isolated from Hai Duong with antimicrobial properties against \(\textit{Xanthomonas oryzea}\) pv. Oryzea." Academia Journal of Biology 43, no. 2 (June 30, 2021): 107–17. http://dx.doi.org/10.15625/2615-9023/15906.

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Endophytic bacteria (EB) possess different beneficial traits. Endophytic microbes are often functional in that they may carry nutrients from the soil into plants, modulate plant development, increase stress tolerance of plants, suppress virulence in pathogens, increase disease resistance in plants, and suppress development of competitor plant species. They may enhance plant development by carrying nutrients from the soil into plants and protect plants against phytopathogens by synthesizing extra-/intracellular proteolytic enzymes, as well as releasing antimicrobial metabolites and competing with pathogens for habitation and nutrients. In this study, we investigated the ability to produce exo/endo-enzymes such as gelatinase, amylase, and catalase, and antagonistic activity of 77 EB strains isolated from lowland rice roots grown in Doan Ket commune, Thanh Mien district, Hai Duong province, Vietnam. Out of 77 isolates, 76 (98.71%) showed the ability to liquefy gelatin after 7 days with different rates of hydrolysis. The test of starch hydrolysis revealed 58 (75.33%) isolates that were able to hydrolyze starch. Fifty-one out of 77 isolates (66.24%) were able to produce catalase. The antagonistic activity of rice root endophytic bacteria was determined against bacterial leaf blight disease-causing pathogen Xanthomonas oryzae pv. oryzae (Xoo), strains X19.2 and VX41. We found that three isolates (TP5, TP7, TP11) showed the ability to inhibit the growth of strain VX41 and twelve isolates (TP3, TP7, TP8, TP9, TP10, TP11, TP12, TP13, TP15, TP17, TP21, TP23) were able to inhibit the growth of strain X19.2. These results are served as a venue for further investigation in planta under the conditions of net house and field trials in order to confirm the potential strains for the development of bioinoculant toward controlling the disease caused by Xoo.
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Guo, Yan You, Cheng Shan Wang, and Jie Yang. "Global-Scale Atmospheric Change with the Tibetan Plateau Uplift in a Coupled Climate Model (CESM)." Advanced Materials Research 962-965 (June 2014): 1392–99. http://dx.doi.org/10.4028/www.scientific.net/amr.962-965.1392.

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Large topography can affect the global climate change significantly. Many studies have revealed that the altitude of the Tibetan Plateau (TP) is related to the Asian regional climate. In order to find how the global-scale atmospheric circulation changes in response to the TP uplift in summer, a fully coupled model, Community Earth System Model (CESM), was used in this paper. Four experiments were run with the altitude of TP set to 25%, 50%, 75%, and 100% of the modern height, respectively (referred to as TP25, TP50, TP75, TP100 experiments). The results show that the uplift of the TP causes the change of the subtropical circulation over the northern hemisphere as well as the southern hemisphere. In the TP25 experiment, the South Asian High (SAH) at the 150mb is comparatively weak, and with the elevated surface heating, the vertical motion in the middle troposphere strengthens greatly. The ascending air over the TP leads to the forming and sustaining of the SAH, a dominate subsystem of the upper troposphere. The perturbation of the SAH propagates in the upper troposphere and stimulates stronger planetary waves on the globe and it also affects the circulation in the low level atmosphere. The subtropical highs over seal level strengthen over the Southern Ocean as well as the North Pacific and Atlantic Oceans. Furthermore, the westerlies around the Antarctica become stronger with the increasing altitude of the TP. This is meaningful that the stronger westerlies may be a forcing to accelerate the Cenozoic global cooling during the geological history.
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Bi, Nan, Yufan Yang, Jianyang Wang, Jingbo Wang, Xiaotian Zhao, Yin Yang, Minyi Zhu, and Luhua Wang. "ctDNA for clonal evolution surveillance and therapeutic efficacy prediction in unresectable locally advanced non-small cell lung cancer under radiotherapy." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): e20555-e20555. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e20555.

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e20555 Background: Therapeutic efficacy differs across unresectable locally advanced non-small cell lung cancer (LA-NSCLC) patients receiving definitive radiotherapy/chemoradiotherapy (RT/CRT), but the underlying resistance mechanism, clonal evolution and molecular prognostic factors remain poorly understood. Methods: Unresectable LA-NSCLC patients treated with definitive RT/CRT were consecutively enrolled between May 2018 and November 2020. Next-generation sequencing covering 474 cancer-relevant genes was performed on plasma ctDNA collected at pre-treatment (TP0), 4-week post-RT (TP1), 1-month post-RT (TP2), 3-month post-RT (TP3), and progression (TP4). Main study endpoints included disease progression, progression-free survival (PFS), death from any cause, overall survival (OS), distant metastasis and distant metastasis free survival. Fisher’s exact test and two-sample t-tests were performed to compare the frequencies and means of independent groups, respectively. The median follow-up time was estimated using the reverse Kaplan-Meier method. Hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox proportional hazards models. Results: A total of 46 patients were included (median age: 63 [range: 40–80], males: 87%, clinical stage IIIB: 52%, squamous cell carcinoma: 54%, TP0 ctDNA shedding: 63%, consolidation immunotherapy: 33%). Twenty-nine (63%) patients developed disease progression by the end of follow-up (median follow-up: 23.7 months), with median PFS and OS being 15.5 and 25.4 months, respectively. The polymerase epsilon ( POLE) mutational signature at TP0 indicated inferior PFS (HR: 5.32, 95% CI: 1.83–15.45) and worse OS (HR: 20.68, 95% CI: 3.94–108.62). Notably, newly-discovered/lost mutations were rarely observed at TP4 when compared to TP0. Patients with a high ratio of mean over max variant allele frequency (m/mVAF) in TP0 samples, indicative of a clonal predominant tumor with a low subclone fraction ( P< 0.01), had relatively poor OS, compared to patients with low m/mVAF (HR: 2.92, 95% CI: 0.82–10.46) or undetectable ctDNA (HR: 3.39, 95% CI: 0.98–11.75). The prognostic value was validated in an independent publicly available dataset of 431 LA-NSCLC patients receiving definitive RT/CRT, showing patients with high m/mVAF demonstrated worse OS than those with low m/mVAF (HR: 1.43, 95% CI: 1.08–1.89). Additionally, increased m/mVAF between TP0 and TP1 indicated an elevated risk for disease progression ( vs. non-increase, HR: 3.49, 95% CI: 1.20–10.16), especially for distant metastasis ( vs. non-increase, HR: 2.85, 95% CI: 0.84–9.69). Conclusions: Our findings demonstrated the clinical value of plasma ctDNA and its derived molecular features in delineating clonal evolution, monitoring therapeutic resistance, and predicting prognosis of LA-NSCLC under definitive RT.
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Dissertations / Theses on the topic "Tp20"

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Nasserasr, Shahla. "The logarithmic method and the solution to the TP2-completion problem." W&M ScholarWorks, 2010. https://scholarworks.wm.edu/etd/1539623566.

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A matrix is called TP2 if all 1-by-1 and 2-by-2 minors are positive. A partial matrix is one with some of its entries specified, while the remaining, unspecified, entries are free to be chosen. A TP2-completion, of a partial matrix T , is a choice of values for the unspecified entries of T so that the resulting matrix is TP2. The TP2-completion problem asks which partial matrices have a TP2-completion. A complete solution is given here. It is shown that the Bruhat partial order on permutations is the inverse of a certain natural partial order induced by TP2 matrices and that a positive matrix is TP2 if and only if it satisfies certain inequalities induced by the Bruhat order. The Bruhat order on permutations is generalized to a partial order, GBr, on nonnegative matrices, and the concept of majorization is generalized to a partial order, DM, on nonnegative matrices. It is shown that these two partial orders are inverses of each other on the set of nonnegative matrices. Using this relationship and the Hadamard exponential transform on nonnegative matrices, explicit conditions for TP2-completability of a given partial matrix are given. It is shown that an m-by- n partial TP2 matrix T is TP2-completable if and only if tijspecified taijij ≥ 1 for every matrix A = (aij) ∈ Mm,n having (1) aij = 0 if tij is unspecified; (2) each row sum and each column sum of A is zero; and (3) 1≤i≤p1≤j≤ qaij ≥ 0, for all (p, q) ∈ {lcub}1, 2, ..., m{rcub} x {lcub}1, 2, ..., n{rcub}. However, there may be infinitely many such conditions, and some of them may be obtainable from others. In order to find a set of minimal conditions, the theory of cones and generators, and the logarithmic method are used. It is shown that the set of matrices used in the exponents of the inequalities forms a finitely generated cone with integral generators. This gives finitely many polynomial inequalities on the specified entries of a partial matrix of given pattern as conditions for TP2-completability. A computational scheme for explicitly finding the generators is given and the combinatorial structure of TP2-completable pattern is investigated.
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Woodcock, Christopher Paul. "A review and development of accelerated test methods for anti-corrosive organic coatings." Thesis, University of Northampton, 2007. http://nectar.northampton.ac.uk/2665/.

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To enable improvements in the development of anti-corrosive coatings quick methods of evaluation are required and several are available which are both qualitative and quantitative. This investigation reviews both types of method, the first in the form of traditional salt spray exposure and the second in the form of electrochemical techniques. The emphasis in the experimental work reported here is on the Electrochemical Noise Measurement (ENM). ENM has been used to monitor coatings under immersion conditions, the aim being to assist a paint company develop a set of more environmentally friendly coatings. The immersion test has also incorporated a temperature cycle which proved effective at separating ‘good’ coatings within a short timeframe. Results showed good correlation between ENM and salt spray testing. Work is also reported which was done with the aim of making the ENM method more practically useful. The standard configuration (‘Bridge’) requires two separate specimens which is unattractive for site work. The Single Substrate (SS) arrangement was developed to get around this problem but this still requires the metal to be connected to the measuring instrument. This is avoided in the most recent development which needs No Connection to Substrate (NOCS). Results are given for immersed samples monitored using the ENM NOCS arrangement and compared with the standard ‘Bridge’ method and DC resistance. Results are also presented using sets of different electrodes (platinum, calomel and silver/silver chloride). This preliminary work has shown that the NOCS method holds great promise. In the laboratory Electrochemical Impedance Spectroscopy (EIS) is also commonly employed to assess the performance of anti-corrosive coatings. Concluding this work a comparison of the ENM and EIS techniques was undertaken on a set of laboratory samples. Results showed that both methods had the ability to rank the performance of coatings. However ENM’s advantages (as outlined above) were confirmed
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Польшина, Т. Д., and T. D. Polshina. "Извлечение фтора из растворов металлургического производства : магистерская диссертация." Master's thesis, б. и, 2020. http://hdl.handle.net/10995/94604.

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Объектом исследования являются ионообменные смолы Lewatit TP 260 и КУ-2×8 в форме Al3+. Цель работы – насыщение катионитов ионами металла (Al3+) и изучение их сорбционной способности по отношению к ионам фтора. В работе проведены теоретические и лабораторные исследования по сорбции фтора на Lewatit TP 260 и КУ-2×8 в Al-форме. Рассмотрен механизм сорбции фтора на катионитах с разными функциональными группами.
The object of the study is Lewatit TP 260 and KU-2×8 ion-exchange resins in the form of Al3+. The purpose of this work is the saturation of cation exchangers with metal ions (Al3+) and the study of their sorption ability with respect to fluorine ions. In this paper, theoretical and laboratory studies on fluorine sorption on Lewatit TP 260 and KU-2×8 in Al-form were carried out. The mechanism of fluorine sorption on cationites with different functional groups is considered.
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Caron, Nicolas. "Activité biologique des protéines de transition TP1 et TP2 de la spermiogenèse maintien de l'intégrité génomique." Mémoire, Université de Sherbrooke, 2001. http://savoirs.usherbrooke.ca/handle/11143/3253.

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La spermatogenèse est le processus par lequel cheminent les cellules reproductrices mâles afin de devenir des spermatozoïdes fonctionnels. La phase haploïde de ce processus est nommée"spermiogenèse". Au cours de celle-ci, la structure de la chromatine somatique est complètement remplacée par une nouvelle structure dépourvue d'histones et beaucoup plus compacte. Afin d'accomplir cette métamorphose, plusieurs protéines de petite taille possédant une charge nette fortement positive dont les protéines de transition (TPs) se succèdent pour lier l'ADN. La littérature décrit les TPs comme étant impliquées dans la compaction du génome. Certains les croient capables de déloger les histones, facilitant ainsi la transformation structurale du génome. Récemment, on associe des problèmes de fertilité masculine à des défauts dans la structure de la chromatine ainsi qu'à la présence de cassures simple brin de l'ADN dans les spermatozoïdes matures. Le but du projet présenté dans ce mémoire était d'initier une démarche expérimentale visant à clarifier le rôle des protéines de transition de la spermiogenèse et de vérifier si elles pouvaient être impliquées dans la prévention des défauts de structure et/ou les cassures simple brin détectées dans l'ADN spermatique d'individus infertiles. Les résultats présentés dans ce mémoire suggèrent par des expériences in vitro ainsi que in vivo que la protéine TP1 pourrait stimuler la réparation des cassures simple brin de l'ADN. Ces résultats supportent l'hypothèse selon laquelle TP1 et TP2 ont des fonctions différentes et non redondantes. Ce travail apporte les premières évidences qui suggèrent que les TPs pourraient être impliquées dans le maintien de l'intégrité du génome spermatique en plus d'aider à sa compaction.
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Handley, Caroline A. "Numerical modelling of two HMX-based plastic-bonded explosives at the mesoscale." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1709.

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Mesoscale models are needed to predict the effect of changes to the microstructure of plastic-bonded explosives on their shock initiation and detonation behaviour. This thesis describes the considerable progress that has been made towards a mesoscale model for two HMX-based explosives PBX9501 and EDC37. In common with previous work in the literature, the model is implemented in hydrocodes that have been designed for shock physics and detonation modelling. Two relevant physics effects, heat conduction and Arrhenius chemistry, are added to a one-dimensional Lagrangian hydrocode and correction factors are identified to improve total energy conservation. Material models are constructed for the HMX crystals and polymer binders in the explosives, and are validated by comparison to Hugoniot data, Pop-plot data and detonation wave profiles. One and two-dimensional simulations of PBX9501 and EDC37 microstructures are used to investigate the response of the bulk explosive to shock loading. The sensitivity of calculated temperature distributions to uncertainties in the material properties data is determined, and a thermodynamic explanation is given for time-independent features in temperature profiles. Hotspots are widely accepted as being responsible for shock initiation in plastic-bonded explosives. It is demonstrated that, although shock heating of crystals and binder is responsible for temperature localisation, it is not a feasible hotspot mechanism in PBX9501 and EDC37 because the temperatures generated are too low to cause significant chemical reaction in the required timescales. Critical hotspot criteria derived for HMX and the binders compare favourably to earlier studies. The speed of reaction propagation from hotspots into the surrounding explosive is validated by comparison to flame propagation data, and the temperature of the gaseous reaction products is identified as being responsible for negative pressure dependence. Hotspot size, separation and temperature requirements are identified which can be used to eliminate candidate mechanisms in future.
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Nguyen, Thi D. T. "Antilarval substituted phenols, distribution of tricyclic pyrones in mice, and synthesis of unnatural amino acids." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18199.

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Doctor of Philosophy
Department of Chemistry
Duy H. Hua
Three research projects were carried out and they are described below. The synthesis of substituted phenolic compounds including halogenated di- and trihydroxybenzenes, aminophenols, and substituted di-tert-butylphenols are described. Redox potentials of the synthesized molecules along with various known laccase substrates were measured, and an inverse relationship between the oxidation potential and the efficiency of oxidation by laccase of halogenated hydroxybenzenes and aminophenols is demonstrated. The synthesized substituted phenols were found to be substrates but not inhibitors of laccase. We discovered a new class of di-tert-butylphenols compounds that inhibits the growth of mosquito larvae at low concentrations. Compound 17, 2,4-di-tert-butyl-6-(3-methyl-2-butenyl) phenol caused greater than 98% mortality of third-instar larvae of Anopheles gambiae in the concentration of 0.18 µM. These compounds do not inhibit laccases. It appears that they affect a new target of the mosquito that is different from those of currently existing pesticides. Two anti-Alzheimer molecules, CP2 and TP70, discovered in our laboratory were studied for their pharmacokinetics and distribution. The distribution of CP2 and TP70 in mouse brain region and various tissues of mice were examined. HPLC analysis revealed that CP2 treatment in primary neurons accumulates in mitochondria fraction. Similarly, the amount of CP2 in the brain tissue from wild type and APP/PS1 mice treated with 25 mg/kg/daily for 2 months also have the highest concentration in the mitochondria fractions in the hippocampus. The results show that CP2 and TP70 can penetrate the blood brain barrier and accumulate in the tissue in significant amounts. Pharmacokinetics and bioavailability of compound TP70 were determined. Area under the curve and bioavailability value F were calculated, and data show that TP70 has a good PK profile and bioavailability. For the preparation of a novel tripeptidyl norovirus 3C-like protease (3CL[superscript]pro) inhibitor, the P3 unnatural amino acid, (S)-3-hydroxyphenylalanine was synthesized. The P3 is designed to increase the polarity with the addition of the alcohol group. After combining the P3 unnatural amino acid with the P1 and P2 to form the novel tripeptidyl compound, a study comparing the relations between the structure and its activity (SAR) will confirm whether prediction is correct in our pursuit for an antiviral therapeutic drug in the form of a protease inhibitor.
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Meetei, Amom Ruhikanta. "Structure-Function Analysis Of Zinc Finger Domains Of Spermatidal Protein TP2." Thesis, 1999. https://etd.iisc.ac.in/handle/2005/1620.

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Meetei, Amom Ruhikanta. "Structure-Function Analysis Of Zinc Finger Domains Of Spermatidal Protein TP2." Thesis, 1999. http://etd.iisc.ernet.in/handle/2005/1620.

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FORNBAUMOVÁ, Iva. "Studium protinádorového působení viru Langat." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-85477.

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The aim of this thesis was to study the efficacy of Langat virus as an oncolytic virus. We subsequently tried to increase its anticancer influence on the basis of combination with some imunomodulators.
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Quintal, Dinarte José França. "Desenvolvimento e Otimização de Sensores para Ensaio do Motor CFM56-3." Master's thesis, 2018. http://hdl.handle.net/10400.6/8321.

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O projeto apresentado neste documento resultou de uma parceria entre a Universidade da Beira Interior e a TAP Manutenção e Engenharia, e teve por objetivo o desenvolvimento de novas soluções de instrumentação para ensaio do reator CFM56-3. Assim, e considerando as estações aerodinâmicas cujos principais parâmetros são desconhecidos ou medidos esporadicamente por falta de instrumentação adequada, o autor optou por centrar-se na obtenção de dados fiáveis de pressão e temperatura na estação aerodinâmica 25. Nesse sentido, e partindo da sonda de pressão e temperatura TP25, adquirida à CFMI e inutilizada face aos problemas estruturais e de instalação apresentados, iniciou-se o presente trabalho, que se desenvolveu em duas etapas. Numa fase inicial, a sonda TP25 foi descrita em detalhe. Em seguida, e de forma a resolver as principais debilidades da ferramenta, apresentou-se um conjunto de propostas, as quais foram submetidas a uma análise comparativa de onde se obteve a solução de adaptação mais adequada aos requisitos do projeto. Assim, procedeu-se à criação de um primeiro exemplar, o qual sofreu alguns ajustes tendo em vista o aperfeiçoamento do processo de instalação no motor. Finalmente, obteve-se um protótipo otimizado, que partindo da sonda TP25 original, integra tecnologia atual e de fácil manuseamento, suportada por uma estrutura que atesta a consistência do conjunto. As melhorias introduzidas pela modificação proposta, permitem atingir os objetivos delineados, na medida em que a sonda de pressão e temperatura com uma nova interface integrada, agora mais robusta, fiável e funcional, pôde retornar ao serviço no banco de ensaios, contribuindo para a monitorização de desempenho do reator CFM56-3. Depois de concluída a primeira etapa do trabalho, na qual se obteve uma solução definitiva para a reparação da sonda TP25, foi realizada uma simulação CFD no Inter-Compressor Duct do reator CFM56-3, a qual possibilitou a recriação das condições do escoamento considerando, ou não, a presença da sonda em referência. Através da aplicação da ferramenta computacional desenvolvida, pretende-se determinar a influência da forma aerodinâmica da sonda nas medições de pressão e temperatura, e avaliar a necessidade de proceder a alterações na configuração da mesma, como condição para a otimização do seu desempenho. Inicialmente, procedeu-se ao dimensionamento in loco da estrutura envolvente do Inter-Compressor Duct, cujas informações técnicas de relevo são mantidas em sigilo pelo fabricante. Posto isto, e recorrendo ao software CATIA V5, obtiveram-se as geometrias dos seguintes componentes: Fan Frame, VBV, Scoop e Sonda TP25, fundamentais na definição da região de fluido com a sonda instalada (ICD Air Volume) e em condições de escoamento não perturbado (ICDAV Without Sensor). A malha aplicada a cada um dos domínios do problema foi desenvolvida com recurso ao HELYX-OS, e o software ANSYS Fluent 16.2 foi utilizado na realização do estudo numérico. Aplicaram-se dois modelos de viscosidade, o Standard K-e e o Realizable K-e. Relativamente às condições fronteira, a descarga do Booster (entrada do domínio) foi definida como Mass Flow Inlet, a entrada do HPC (saída do domínio) foi definida como Pressure Outlet, e as demais superfícies, incluindo os elementos sensores da sonda (ICD Air Volume), como fronteira do tipo Wall. Após concluídas as simulações e validado o modelo, obtiveram-se as distribuições dos principais parâmetros termodinâmicos ao longo dos domínios considerados. Os resultados alcançados comprovaram a interferência do corpo da sonda TP25 sobre as características do escoamento, pelo que a sua influência foi quantificada por intermédio do erro de medição de pressão e temperatura, o qual permaneceu abaixo dos 5% e 1.5%, respetivamente. Pôde concluir-se então, que as medições obtidas no Inter-Compressor Duct, não estando imunes ao erro, garantem uma monitorização adequada dos principais parâmetros termodinâmicos do motor. Deste modo, não se justifica a otimização da forma aerodinâmica da sonda TP25, dado que as melhorias resultantes dificilmente justificarão os custos associados ao desenvolvimento de um novo protótipo.
The project presented in this document is the result of a partnership between the University of Beira Interior and TAP Maintenance & Engineering and aimed to develop new instrumentation solutions for the CFM56-3 engine testing. Thus, considering the aerodynamic stations whose main parameters are unknown or sporadically measured due to lack of adequate instrumentation, the author chose to focus on obtaining reliable data of pressure and temperature in the aerodynamic station 25. Therefore, and starting from the temperature and pressure probe TP25, acquired from CFMI and rendered useless due to the structural and installation problems that were continuously brought up, the present work was started and developed in two complementary stages. At an early stage of the work, the TP25 probe was described in detail. Then, to solve the major weaknesses of the tool, a set of proposals were presented and submitted to a comparative study, to obtain the most adequate adaptation solution for the project requirements. Thus, a first prototype was created, which was improved to optimize its installation process in the engine. Then, a final prototype was obtained, which starting from the original configuration of the TP25 probe, integrates current and easy handling technology, supported by a structure which attests the robustness of the whole set. The improvements introduced by the suggested modification, allow to achieve the outlined goals, since the pressure and temperature probe with a new integrated interface, now more robust, reliable and functional, could return to its task in the test bench, contributing to the performance monitoring of the CFM56-3 engine. After completing the first stage of the work, in which a definitive solution was obtained for the repair of the TP25 probe, a CFD simulation was performed in the Inter-Compressor Duct of the CFM56-3 engine, which enabled the prediction of the fluid flow conditions considering, or not, the presence of the afore mentioned probe. By applying the developed software tool, we wanted to determine the influence of the aerodynamic shape of the probe on the pressure and temperature measurements, and to assess the need to make changes in the configuration of the probe as a condition for the optimization of its performance. Initially, the on-site dimensioning of the surrounding structure of the Inter-Compressor Duct was carried out, whose technical information is kept confidential by the manufacturer. With the CATIA V5 software, the geometry of the various components was obtained, with relevance to the present study - Fan Frame, VBV, Scoop and TP25 Probe, which enabled the definition of the fluid region with the probe installed (ICD Air Volume) and under undisturbed flow conditions (ICDAV Without Sensor). The numerical mesh applied to each domain was developed using the HELYX-OS, and the ANSYS Fluent 16.2 software was used to carry out the numerical study. Two viscous models were applied, the Standard K-e and the Realizable K-e. For the boundary conditions, the Booster discharge (domain entry) was defined as Mass Flow Inlet, the HPC inlet (domain exit) was defined as Pressure Outlet, and the other surfaces, including the sensing elements of the probe (ICD Air Volume), as Wall boundary. After the simulations were completed and the model validated, the distributions for the main thermodynamic parameters along the considered domains were presented. The results confirm the interference of the TP25 probe body on the flow characteristics, so its influence was quantified by means of the pressure and temperature measurement error, which remained below 5% and 1.5%, respectively. It can, therefore, be concluded that the measurements obtained from the Inter-Compressor Duct, not being immune to error, ensure adequate monitoring of the main thermodynamic parameters of the engine. Thus, the optimization of the aerodynamic shape of the TP25 probe is not justified, since the improvements will hardly justify the costs associated with the development of a new prototype.
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Books on the topic "Tp20"

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CompTIA Security+ Study Guide: Exam SY0-501. Wiley & Sons, Incorporated, John, 2017.

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(ISC)2 CISSP Certified Information Systems Security Professional Official Study Guide. Wiley & Sons, Incorporated, John, 2018.

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(ISC)2 CISSP Certified Information Systems Security Professional Official Study Guide. Wiley & Sons, Incorporated, John, 2021.

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Hmh, Hmh. Hybrid Replacement Classroom Package W/NY Tp2-Volume Student Edition Grade K with 1 Year Digital 2015. Houghton Mifflin Harcourt Publishing Company, 2016.

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Houghton Mifflin Harcourt Publishing Company. Hybrid Replacement Classroom Package W/NY Tp2-Volume Student Edition Grade 5 with 1 Year Digital 2015. Houghton Mifflin Harcourt Publishing Company, 2016.

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Houghton Mifflin Harcourt Publishing Company. Hybrid Replacement Classroom Package W/NY Tp2-Volume Student Edition Grade 6 with 1 Year Digital 2015. Houghton Mifflin Harcourt Publishing Company, 2016.

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Houghton Mifflin Harcourt Publishing Company. Hybrid Replacement Classroom Package W/NY Tp2-Volume Student Edition Grade 4 with 1 Year Digital 2015. Houghton Mifflin Harcourt Publishing Company, 2016.

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Hmh, Hmh. Hybrid Replacement Classroom Package W/NY Tp2-Volume Student Edition Grade 2 with 1 Year Digital 2015. Houghton Mifflin Harcourt Publishing Company, 2016.

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Hmh, Hmh. Hybrid Replacement Classroom Package W/NY Tp2-Volume Student Edition Grade 1 with 1 Year Digital 2015. Houghton Mifflin Harcourt Publishing Company, 2016.

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HARCOURT, HOUGHTON MIFFLIN. GoMath! Spanish with 1 Year Digital: Hybrid Replacement Classroom Package w/NY TP2-Volume Student Edition Grade 3. HOUGHTON MIFFLIN HARCOURT, 2016.

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Book chapters on the topic "Tp20"

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Huang, Chung-Ming, Chia-Ching Yang, and Chun-Yu Tseng. "A Distributed Telematics Peer-to-Peer (D-TP2P) Networking System for Service Discovery." In Smart Spaces and Next Generation Wired/Wireless Networking, 311–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14891-0_28.

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Sanyal, Gautam, Dorothy Marquis-Omer, and C. Russell Middaugh. "Biophysical Characterization and Formulation of TP40: A Chimeric Protein that Requires a pH-Dependent Conformational Change for Its Biological Activity." In Pharmaceutical Biotechnology, 365–92. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/0-306-47452-2_10.

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"TP120." In Encyclopedia of Signaling Molecules, 5556. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103911.

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Monteiro Neto, João Luiz Lopes, Jose de Anchieta Alves de Albuquerque, Roberto Tadashi Sakazaki, Richard Alcides Molina Alvarez, Ignacio Lund Gabriel da Silva Carmo, Sonicley da Silva Maia, Ana Karyne Pereira Melo, Rayra de Souza Ribeiro, Aldelônio Alves da Silva, and Brenda Ariana Medeiros de Sousa. "Ambience and substrates for the development of pepper seedlings (Capsicum chinense Jacq.)." In UNITING KNOWLEDGE INTEGRATED SCIENTIFIC RESEARCH FOR GLOBAL DEVELOPMENT. Seven Editora, 2023. http://dx.doi.org/10.56238/uniknowindevolp-018.

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In order to evaluate the influence of different environments and substrates on the production of chili pepper seedlings, an experiment was installed in a completely randomized design (DIC), with treatments arranged in subdivided plots. Five environments were evaluated: EA - agricultural greenhouse; TV35 - red screen with 35% shading; TV50 - red screen with 50% shading; TP35 - silver screened with 35% shading and TP50 - silver screened with 50% shading, and four substrates: S1 - OrganoAmazon®; S2 - OrganoAmazon® and PuroHumus®; S3 - OrganoAmazon, PuroHumus, soil and manure, and S4 (OrganoAmazon®®, PuroHumus®®, soil, manure and carbonized rice husk). In the photoconverter meshes TP35 and TP50, the pepper seedlings grown in the substrate S2 provided high IQD. The combination of agricultural greenhouse (EA) and S3 substrate promote superior quality chili pepper seedlings. S4 and S3 substrates are more affordable alternatives to the production of chili pepper seedlings. The photoconverter screens, associated with alternative substrates, do not favor the production of quality pepper seedlings.
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"tp0 . 0 0 . 4 0 . 8." In ROC Curves for Continuous Data, 34–49. Chapman and Hall/CRC, 2009. http://dx.doi.org/10.1201/9781439800225-4.

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J., Shanthalakshmi Revathy, Uma Maheswari N., and Sasikala S. "Enhanced BiLSTM Model for EEG Emotional Data Analysis." In Principles and Applications of Socio-Cognitive and Affective Computing, 51–63. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3843-5.ch005.

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Emotion recognition based on biological signals from the brain necessitates sophisticated signal processing and feature extraction techniques. The major purpose of this research is to use the enhanced BiLSTM (E-BiLSTM) approach to improve the effectiveness of emotion identification utilizing brain signals. The approach detects brain activity that has distinct characteristics that vary from person to person. This experiment uses an emotional EEG dataset that is publicly available on Kaggle. The data was collected using an EEG headband with four sensors (AF7, AF8, TP9, TP10), and three possible states were identified, including neutral, positive, and negative, based on cognitive behavioral studies. A big dataset is generated using statistical brainwave extraction of alpha, beta, theta, delta, and gamma, which is then scaled down to smaller datasets using the PCA feature selection technique. Overall accuracy was around 98.12%, which is higher than the present state of the art.
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Conference papers on the topic "Tp20"

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"Session TP2b: Echo cancellation." In 2014 48th Asilomar Conference on Signals, Systems and Computers. IEEE, 2014. http://dx.doi.org/10.1109/acssc.2014.7094741.

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"ACSSC 2018 Session TP2a." In 2018 52nd Asilomar Conference on Signals, Systems, and Computers. IEEE, 2018. http://dx.doi.org/10.1109/acssc.2018.8645244.

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"ACSSC 2018 Session TP2b." In 2018 52nd Asilomar Conference on Signals, Systems, and Computers. IEEE, 2018. http://dx.doi.org/10.1109/acssc.2018.8645498.

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"Session TP2b: Massive MIMO systems." In 2017 51st Asilomar Conference on Signals, Systems, and Computers. IEEE, 2017. http://dx.doi.org/10.1109/acssc.2017.8335609.

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Bodi, C. A., N. Bojor, and I. Kovacs. "Optoelectronic telependulum station model TP202." In 2008 IEEE International Conference on Automation, Quality and Testing, Robotics. IEEE, 2008. http://dx.doi.org/10.1109/aqtr.2008.4588933.

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"Session TP2b: Neural signal processing." In 2009 Conference Record of the Forty-Third Asilomar Conference on Signals, Systems and Computers. IEEE, 2009. http://dx.doi.org/10.1109/acssc.2009.5470063.

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Simeone, Osvaldo. "Session TP2a: Cognitive radio I." In 2011 45th Asilomar Conference on Signals, Systems and Computers. IEEE, 2011. http://dx.doi.org/10.1109/acssc.2011.6190249.

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Simeone, Osvaldo. "Session TP2b: Cognitive radio II." In 2011 45th Asilomar Conference on Signals, Systems and Computers. IEEE, 2011. http://dx.doi.org/10.1109/acssc.2011.6190316.

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"Session TP2 Synchronization." In Conference Record of the Thirty-Ninth Asilomar Conference onSignals, Systems and Computers, 2005. IEEE, 2005. http://dx.doi.org/10.1109/acssc.2005.1599924.

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"Session TP2a: Bioinformatics and DNA computing." In 2014 48th Asilomar Conference on Signals, Systems and Computers. IEEE, 2014. http://dx.doi.org/10.1109/acssc.2014.7094677.

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Reports on the topic "Tp20"

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Onions, J. P., and M. T. Rose. ISO-TP0 bridge between TCP and X.25. RFC Editor, December 1988. http://dx.doi.org/10.17487/rfc1086.

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