Relevant bibliographies by topics / Total synthesis

Academic literature on the topic 'Total synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 July 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Total synthesis.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Total synthesis"

1

Dai, Mingji, Xinpei Cai, and Yu Bai. "Total Syntheses of Spinosyn A." Synlett 29, no. 20 (September 7, 2018): 2623–32. http://dx.doi.org/10.1055/s-0037-1610249.

Full text
Abstract:
Spinosyn A is an important polycyclic natural product with impressive insecticidal activity and has been used worldwide in agriculture as the major component of Spinosad. Herein, four chemical total syntheses of spinosyn A are summarized. Its biosynthesis and a chemoenzymatic total synthesis are discussed as well.1 Biosynthesis2 The Evans Synthesis3 The Paquette Synthesis4 The Roush Synthesis5 The Liu Synthesis6 The Dai Synthesis7 Conclusions
APA, Harvard, Vancouver, ISO, and other styles
2

Uwamori, Masahiro, and Masahisa Nakada. "Collective Total Synthesis of PPAPs: Total Synthesis of Clusianone via Intramolecular Cyclopropanation." Natural Product Communications 8, no. 7 (July 2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800721.

Full text
Abstract:
The total synthesis of clusianone was accomplished through the stereoselective construction of a bicyclo[3.3.1]nonane derivative via a three-step sequence which has been utilized for the total syntheses of nemorosone garsubellin A and hyperforin: intramolecular cyclopropanation formation of a geminal dimethyl group and regioselective ring opening of cyclopropane. Further elaboration including chemo- and stereoselective hydrogenation to generate the C7 stereogenic center and cross-metathesis to construct prenyl groups in the side-chains was employed to complete the total synthesis of clusianone.
APA, Harvard, Vancouver, ISO, and other styles
3

Anderson, Zoe J., and David J. Fox. "Total synthesis of the azolemycins." Organic & Biomolecular Chemistry 14, no. 4 (2016): 1450–54. http://dx.doi.org/10.1039/c5ob02520f.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Ndoile, Monica M., and Fanie R. van Heerden. "Total synthesis of ochnaflavone." Beilstein Journal of Organic Chemistry 9 (July 8, 2013): 1346–51. http://dx.doi.org/10.3762/bjoc.9.152.

Full text
Abstract:
The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental conditions for the oxidative cyclization to form ochnaflavone were established.
APA, Harvard, Vancouver, ISO, and other styles
5

Dong, Gao, Bohui Li, and George A. O'Doherty. "Total and formal syntheses of fostriecin." Organic Chemistry Frontiers 7, no. 22 (2020): 3608–15. http://dx.doi.org/10.1039/d0qo01121e.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Ke, Shanwen, and Chenghao Pan. "Total synthesis of Oboflavanone B." Journal of Physics: Conference Series 2608, no. 1 (October 1, 2023): 012043. http://dx.doi.org/10.1088/1742-6596/2608/1/012043.

Full text
Abstract:
Abstract Oboflavanone B, a revision of Oboflavanone A, has unique structure. Intrigued by its key 2,8-dioxabicyclo(3.3.1)nonane structure and chromanone structure, this paper discussed and reported a proposal towards the synthesis of this product. This work provides a theoretically feasible retrosynthesis, which utilized coupling reactions to connect the two main parts of the natural product. The key strategy of these syntheses involves Heck reactions, Fries rearrangement and addition reactions. To ensure the chiral of the target product, the chiral of the reactant was restricted in this work. The synthesis went through a total 12 steps process, containing 4 steps on protecting and deprotecting reactions. All the substrates given in each step are available in this strategy.
APA, Harvard, Vancouver, ISO, and other styles
7

Chen, Fen-Er, and Lei Chen. "Total Synthesis of Camptothecins: An Update." Synlett 28, no. 10 (March 15, 2017): 1134–50. http://dx.doi.org/10.1055/s-0036-1588738.

Full text
Abstract:
Over the last few decades, considerable research efforts have been directed toward the development of effective chemical syntheses of camptothecin and its analogs. The last comprehensive review of this area was published in 2003 and many effective new methods have since been reported for the stereoselective synthesis of the camptothecin alkaloids. In this account, we have summarized most of the novel synthetic approaches developed for the synthesis of camptothecins during the last decade. We have focused on strategies for the construction of the pentacyclic ring system and the different methods used to install the chiral quaternary center on the E ring of camptothecin.1 Introduction2 Synthesis of Racemic Camptothecins3 Enantioselective Synthesis of Camptothecins3.1 Sharpless Asymmetric Dihydroxylation3.2 Catalytic Asymmetric Cyanosilylation3.3 Auxiliary-Induced Asymmetric Carbonyl Addition3.4 Catalytic Asymmetric Ethylation3.5 Asymmetric Hydroxylation4 Conclusion
APA, Harvard, Vancouver, ISO, and other styles
8

Huang, Deng-Ming, Hui-Jing Li, Jun-Hu Wang, and Yan-Chao Wu. "Asymmetric total synthesis of talienbisflavan A." Organic & Biomolecular Chemistry 16, no. 4 (2018): 585–92. http://dx.doi.org/10.1039/c7ob02837g.

Full text
Abstract:
The first asymmetric total syntheses of talienbisflavan A and bis-8,8′-epicatechinylmethane as well as a facile synthesis of bis-8,8′-catechinylmethane has been accomplished from readily available starting materials by using a newly developed direct regioselective methylenation of catechin derivatives as one of the key steps.
APA, Harvard, Vancouver, ISO, and other styles
9

Fay, Nicolas, Rémi Blieck, Cyrille Kouklovsky, and Aurélien de la Torre. "Total synthesis of grayanane natural products." Beilstein Journal of Organic Chemistry 18 (December 12, 2022): 1707–19. http://dx.doi.org/10.3762/bjoc.18.181.

Full text
Abstract:
Grayananes are a broad family of diterpenoids found in Ericaceae plants, comprising more than 160 natural products. Most of them exhibit interesting biological activities, often representative of Ericaceae use in traditional medicine. Over the last 50 years, various strategies were described for the total synthesis of these diterpenoids. In this review, we survey the literature for synthetic approaches to access grayanane natural products. We will focus mainly on completed total syntheses, but will also mention unfinished synthetic efforts. This work aims at providing a critical perspective on grayanane synthesis, highlighting the advantages and downsides of each strategy, as well as the challenges remaining to be tackled.
APA, Harvard, Vancouver, ISO, and other styles
10

Liu, L., S. Wu, Q. Wang, M. Zhang, B. Wang, G. He, and G. Chen. "Total synthesis of teixobactin and its stereoisomers." Organic Chemistry Frontiers 5, no. 9 (2018): 1431–35. http://dx.doi.org/10.1039/c8qo00145f.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Total synthesis"

1

Watson, Christine Anne Louise. "Total synthesis of bistheonellic acid B/ total synthesis of scytophycin C." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627216.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Mitra, Soumya. "Total synthesis of gomisin O asymmetric total syntheses of eupomatilones 1, 2 and 5; and studies towards total synthesis of mayolide A /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189449580.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Chan, Bryan Ka Ip. "Total synthesis of streptonigrone." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31581.

Full text
Abstract:
This thesis describes the total synthesis of streptonigrone. The centerpiece of our route to the target molecule is a facile one-pot construction of 3-alkylpyridones developed in our laboratory. The quinoline segment of the target molecule, prepared through a Conrad-Limpach synthesis, was condensed with 2-benzyloxy-3,4-dimethoxybenzaldehyde to afford a chalcone intermediate suitable for our pyridine-forming reaction. The assembly of the central 3-methylpyridone ring of the natural product was then accomplished through the merger of the chalcone with 2-cyanopropanamide. Functionalization of the pyridone was then completed through an anionic sequence.
Science, Faculty of
Chemistry, Department of
Graduate
APA, Harvard, Vancouver, ISO, and other styles
4

Shelton, Ruth E. "Total synthesis of peduncularine." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526451.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Sparling, Brian Andrew. "Total Synthesis of Hyperforin." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11098.

Full text
Abstract:
Hyperforin is the component of the medicinal herb St. John's Wort (Hypericum perforatum) responsible for its antidepressant activity. It works by blocking the reuptake of a variety of neurotransmitters through a unique mechanism of action and may be a critical lead for the treatment of depression and possibly other human diseases. However, the therapeutic potential of hyperforin is severely handicapped by its poor water solubility, facile oxidative degradation, and potent activation of pregnane X receptor, leading to increased expression of many genes involved in xenobiotic metabolism. Access to a wide variety of hyperforin analogs is critical for mitigating these shortcomings while maintaining therapeutic activity. While limited semisynthetic manipulation of isolated hyperforin is feasible, total synthesis is the only possible means of obtaining diverse hyperforin analogs.
Chemistry and Chemical Biology
APA, Harvard, Vancouver, ISO, and other styles
6

Baldwin, Ian Robert. "Total synthesis of acetoxyodontoschismenol." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284653.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Chen, Cheng Yi. "Total synthesis of (+)-stenine /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487684245465948.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Li, Fang. "Total Synthesis of (-)-Acutumine." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2193.

Full text
Abstract:
Acutumine is a tetracyclic alkaloid isolated from the Asian vine Menispermum dauricum with selective T-cell cytotoxicity and antiamnestic properties. We have developed a total synthetic route to this congested alkaloid, during which we also found a novel, stereoselective radical-crossover reaction that combines an intramolecular radical conjugate addition with a subsequent enolate hydroxylation. Key features of this synthesis also include a reagent-controlled diastereoselective ketone allylation, an anionic oxy-Cope rearrangement to form a congested quaternary sterocenter, a pyridine-mediated selective ozonolysis, and a Lewis acid promoted Michael-type cyclization.
APA, Harvard, Vancouver, ISO, and other styles
9

Phillips, Andrew. "Studies towards the total synthesis of patellazole B." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269364.

Full text
Abstract:
The patellazoles are a family of marine polyketide natural products first isolated from Lissoclinum patella in 1988 by both the Moore and Ireland groups. They exhibit significant cytotoxicity against the HCT 116 human colon tumour cells. To date however, their full 3D stereostructure have yet to be elucidated, which has hindered their development as potential drugs, and hampered full investigation into their biological mechanism of action and has deterred total synthesis efforts. This thesis describes synthetic efforts towards Patellazole B, which exhibits the highest potency of the three main congeners. To fully elucidate the structure and renew interest in the patellazoles as anticancer compounds, we have developed a flexible and modular synthesis that aims to define the unknown stereocentres within the pertinent region and allow for rapid fragment union. Compound 36 has been chosen as an initial target for NMR comparison studies. The synthesis of all eight diastereomers of this macrocycle should aid determination of the four unknown stereocentres. Chapter 2 describes the synthesis of the C1–C12 fragment, focusing on the configuring of the C5 methyl stereocentre and the construction of the C7-C10 stereotetrad via a boron-mediated anti aldol with an in-situ reduction. In the third chapter, the synthesis of the C13-C19 fragment is outlined. A boron-mediated glycolate aldol has been used to install the C16-C17 anti stereochemistry and a substrate-controlled reduction at C15 delivered the hydroxyl with high diastereoselectivity. Studies into the C¬17¬ methylation are also described. Chapter 4 describes the synthesis of one possible diastereomer of the C20-C25 fragment, as a template for the preparation of the other 7 possible diastereomers. The route therefore employs only catalyst based control methods to install the three stereocentres, utilising a Sharpless asymmetric epoxidation and Evans aldol to construct the stereotriad. The 22R, 23S, 24S diastereomer has been initially chosen to investigate the later chemistry. Chapter 5 contains discussion of the ongoing work investigating fragment union and formation of the macrocycle. A Heck coupling reaction has been employed to construct the C19-C20 bond and a Suzuki coupling reaction has been developed to facilitate the C12-C13 bond formation. These two cross couplings have delivered the C1 - C25 fragment, 360, the final compound reported in this thesis, which is three steps away from the completed macrocycle and six from compound 36. The experimental procedures and spectroscopic characterisation of the synthesised intermediates can be found in Chapter 6 and the Appendix.
APA, Harvard, Vancouver, ISO, and other styles
10

Rivas, Fatima R. "Synthetic studies towards the total synthesis of norzoanthamine." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3221252.

Full text
Abstract:
Thesis (Ph. D.)--University of California, San Diego, 2006.
Title from first page of PDF file (viewed September 8, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Total synthesis"

1

Nicolaou, K. C. Classics in total synthesis: Targets, strategies, methods. Weinheim: VCH, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Li, Jie Jack, and E. J. Corey, eds. Total Synthesis of Natural Products. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-34065-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

ApSimon, John, ed. Total Synthesis of Natural Products. Hoboken, NJ, USA: John Wiley & Sons, Inc., 1988. http://dx.doi.org/10.1002/9780470129708.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

ApSimon, John, ed. Total Synthesis of Natural Products. Hoboken, NJ, USA: John Wiley & Sons, Inc., 1991. http://dx.doi.org/10.1002/9780470129715.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

ApSimon, John, ed. Total Synthesis of Natural Products. Hoboken, NJ, USA: John Wiley & Sons, Inc., 1992. http://dx.doi.org/10.1002/9780470129722.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Goldsmith, David, Michael C. Pirrung, and Andrew T. Morehead, eds. Total Synthesis of Natural Products. Hoboken, NJ, USA: John Wiley & Sons, Inc., 1997. http://dx.doi.org/10.1002/9780470129739.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Goldsmith, David, Michael C. Pirrung, Andrew T. Morehead, and Bruce G. Young, eds. Total Synthesis of Natural Products. Hoboken, NJ, USA: John Wiley & Sons, Inc., 1999. http://dx.doi.org/10.1002/9780470129746.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Zografos, Alexandros L., ed. From Biosynthesis to Total Synthesis. Hoboken, NJ: John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118754085.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Matsuoka, Junpei. Total Synthesis of Indole Alkaloids. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8652-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Gong, Jianxian. Total Synthesis of (±)-Maoecrystal V. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54304-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Total synthesis"

1

Ohno, Hiroaki, Norihito Arichi, and Shinsuke Inuki. "Nonbiomimetic Total Synthesis of Polycyclic Alkaloids." In Modern Natural Product Synthesis, 413–38. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1619-7_19.

Full text
Abstract:
AbstractIn nonbiomimetic natural product synthesis, there are no restrictions on the design of synthetic routes; however, the feasibility of the planned routes is often completely unknown. To discover more efficient and creative syntheses of natural products, and to identify bioactive natural product derivatives that have never been synthesized in nature, our group is engaged in the nonbiomimetic total synthesis of indole alkaloids. In this chapter, we describe our nonbiomimetic total syntheses of quinocarcin, dictyodendrins A–F, and zephycarinatines C and D, by employing alkyne-based approaches and reductive radical spirocyclization. We also describe our efforts in the identification of bioactive alkaloid derivatives.
APA, Harvard, Vancouver, ISO, and other styles
2

Meguro, Yasuhiro, Masaru Enomoto, and Shigefumi Kuwahara. "Total Synthesis of Amycolamicin." In Modern Natural Product Synthesis, 31–54. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1619-7_2.

Full text
Abstract:
AbstractAmycolamicin (also called kibdelomycin) produced by two species of soil actinomycetes is a potent antibiotic against a broad range of drug-resistant bacteria with a novel binding mode to bacterial type II DNA topoisomerases and with no cross-resistance to existing antibacterial agents. The unique hybrid molecular architecture of amycolamicin attracted interest of many synthetic organic chemists and three total syntheses have been reported so far. In this chapter, we describe our total synthesis of amycolamicin in detail, which features a nucleophilic addition of a vinyllithiun reagent to an α-siloxy-β-alkoxy ketone to afford a tertiary alcohol as a single diastereomer, a highly diastereoselective intramolecular Diels–Alder reaction of a tetraenal with an unprotected hydroxy group to construct a trans-decalin unit incorporated in amycolamicin, an exclusively stereoconvergent N-acylation of an anomeric N-glycoside mixture bearing a cis-fused bicyclic carbonate system, and the exploitation of the cyclic carbonate as a vicinal diol protecting group and also as a masked β-hydroxy carbamate structure. Additionally, two other total syntheses accomplished by the Li and Baran groups as well as syntheses of partial structures of amycolamicin hitherto reported are also outlined in brief.
APA, Harvard, Vancouver, ISO, and other styles
3

Kilenyi, S. N. "Asymmetric total synthesis." In Asymmetric Synthesis, 192–229. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-1346-5_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Tsukano, Chihiro, Motohiro Yasui, and Yoshiji Takemoto. "Total Synthesis of Avenaol." In Modern Natural Product Synthesis, 381–411. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1619-7_18.

Full text
Abstract:
AbstractAvenaol is a terpene with a unique all-cis cyclopropane in which all bulky substituents are oriented in the same direction. It is categorized into a non-canonical strigolactone. We have synthesized alkylidenecyclopropanes by Rh-catalyzed intramolecular cyclopropanation of allenes, followed by iridium-catalyzed diastereoselective double bond isomerization to construct all-cis cyclopropanes. Subsequently, distinction of the two hydroxymethyl groups of 1,3-diol by an intramolecular SN1-type reaction, followed by cleavage of the tetrahydropyranyl ring by regioselective C–H oxidation, led to the desired stereochemistry at the C-ring lactone. Using these key steps, the first racemic total synthesis of avenaol was achieved, and the proposed relative configuration of avenaol was proved synthetically. Furthermore, we developed a stereoselective introduction of D-ring butenolide via chiral thiourea-quaternary ammonium salt-catalyzed dynamic kinetic optical resolution. Then, by applying this method to synthetic intermediates, (+)-avenaol was successfully synthesized. This chapter details the total synthesis of avenaol, including failed attempts.
APA, Harvard, Vancouver, ISO, and other styles
5

Tohma, Hirofumi, and Yasuyuki Kita. "Synthetic Applications (Total Synthesis and Natural Product Synthesis)." In Hypervalent Iodine Chemistry, 209–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-46114-0_8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Stevens, R. V. "Alkaloid Synthesis." In Total Synthesis of Natural Products, 439–554. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470129661.ch3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Narang, Saran A., Wing L. Sung, and Robert H. Wightman. "Gene Synthesis." In Total Synthesis of Natural Products, 51–84. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470129692.ch2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Sakata, Juri, Masashi Shimomura, and Hidetoshi Tokuyama. "The Asymmetric Total Synthesis of Discorhabdin B, H, K, and Aleutianamine." In Modern Natural Product Synthesis, 103–25. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1619-7_5.

Full text
Abstract:
AbstractThis review article summarizes the general introduction of discorhabdin marine alkaloids and the synthetic efforts in developing congeners with a hexacyclic N, S-acetal structure, which are major constituents of discorhabdin. Our total synthesis of (+)-discorhabdin B is discussed in detail following the introduction of the biosynthetic pathway and early synthetic studies, which include the landmark first total synthesis of discorhabdin A. Furthermore, previous synthetic studies on more structurally complex congeners with C6–N15 bonds are introduced, followed by the first total synthesis of (–)-discorhabdin H and (+)-discorhabdin K, which are achieved by our research group. Finally, the isolation, structure determination, and proposed biosynthesis of the structurally intriguing congener aleutianamine are summarized. Then, the first total synthesis of aleutianamine, which involves an unprecedented reductive skeletal rearrangement of N-Ts-(+)-discorhabdin B to N-Ts-aleutianamine, is discussed.
APA, Harvard, Vancouver, ISO, and other styles
9

Higgins, Tyler F., and Jeffrey D. Winkler. "Total Synthesis of Ingenol." In Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules, 171–92. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-6244-6_8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Marqués-López, Eugenia, and Raquel P. Herrera. "Organocatalysis in Total Synthesis." In Comprehensive Enantioselective Organocatalysis, 1359–83. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527658862.ch44.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Total synthesis"

1

Naciuk, Fabrício Fredo, Rebeca Malanzuk, Luiz Antonio Mazzini Fontoura, and Paulo C. M. L. Miranda. "Total Synthesis of Isoellipticine." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013913103848.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Milan, Julio Cesar, Fabrício Fredo Naciuk, and and Paulo Miranda. "Total synthesis of caulibugulone B." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0243-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Milan, Julio Cesar, Fabrício Fredo Naciuk, and and Paulo Miranda. "Total synthesis of caulibugulone B." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0257-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

P.Sant’Ana, Danilo, Renata Marcia de Fiqueiredo, Jean-Marc Campagne, and Luiz Carlos Dias. "Studies toward total synthesis of tautomycetin." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0158-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Barbosa, Jaqueline Rosa C., and Mauricio Moraes Victor. "Strategies for Total Synthesis of Pyrenophorin." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013102145639.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Sant’Ana, Danilo P., Renata Marcia de Fiqueiredo, Jean-Marc Campagne, and Luiz Carlos Dias. "Studies toward total synthesis of tautomycetin." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013818172811.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Lasarczyk, Christian W. G., and Wolfgang Banzhaf. "Total synthesis of algorithmic chemistries." In the 2005 conference. New York, New York, USA: ACM Press, 2005. http://dx.doi.org/10.1145/1068009.1068285.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Peña, Stella, Laura Scarone, and Gloria Serra. "Towards the Total Synthesis of Aerucyclamide B." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0068-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Silva, Marcelo F. R., Dayvson J. Palmeira, Leandro H. Andrade, and and Paulo H. Menezes. "Studies Toward the Total Synthesis of Seselidiol." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0221-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Chu, C. Henry, and Edward J. Delp. "Image Motion Recovery Using the Method of Total Least Squares." In Signal Recovery and Synthesis. Washington, D.C.: Optica Publishing Group, 1989. http://dx.doi.org/10.1364/srs.1989.tha1.

Full text
Abstract:
Recovering image motion in the form of a velocity field is particularly useful in image analysis when the signal-to-noise ratio is low in individual frames of an image sequence. The velocity vector of a point on an image plane is the position change of the projection of an object point due to a change of viewing angle between the sensor and the object point. A change in the viewing angle can be caused by the velocity of the sensor, or the movement of the object point in the scene, or both. The velocity vector is thus an approximation to the velocity of the image point.
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Total synthesis"

1

Buck, Suzanne B., and Gunda Georg. Total Synthesis of Cryptophycin A and Analogs. Fort Belvoir, VA: Defense Technical Information Center, April 1999. http://dx.doi.org/10.21236/ada381236.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Rubin, Yves F. Total Synthesis of Buckminsterfullerene (C60) and Endohedral Metal Complexes. Fort Belvoir, VA: Defense Technical Information Center, August 1997. http://dx.doi.org/10.21236/ada328578.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Meng, Dongfang. Strategy Toward the Total Synthesis of Epothilones A and B. Fort Belvoir, VA: Defense Technical Information Center, July 1999. http://dx.doi.org/10.21236/ada374231.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Lee, Chul Bom, and S. Danieshafsky. Strategy Toward the Total Synthesis of Epothilones A and B. Fort Belvoir, VA: Defense Technical Information Center, July 2000. http://dx.doi.org/10.21236/ada392458.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Avery, Mitchell A. Drug Development of the Antimalarial Agent Artemisinin: Total Synthesis, Analog Synthesis, and Structure-Activity Relationship Studies. Fort Belvoir, VA: Defense Technical Information Center, August 1990. http://dx.doi.org/10.21236/adb152141.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Alexander, Timothy, and Ole Seehausen. Diversity, distribution and community composition of fish in perialpine lakes. "Projet Lac" synthesis report. Eawag, 2021. http://dx.doi.org/10.55408/eawag:24051.

Full text
Abstract:
Projet Lac was a large project conducted by Eawag and the University of Bern to quantitatively survey, for the first time, whole-lake fish communities in the large and deep lakes in and around the European Alps using multiple, standardised sampling methods. Starting in 2010, in total 35 lakes were investigated across Switzerland, Italy, France, Germany and Austria, with more than 106 fish species recorded. This report brings together key findings, compares fish communities among lakes, investigates their relationship to environmental parameters, and provides an overview of drivers of biodiversity and community structure in this important ecosystem.
APA, Harvard, Vancouver, ISO, and other styles
7

Barash, Itamar, and Robert E. Rhoads. Translational Mechanisms that Govern Milk Protein Levels and Composition. United States Department of Agriculture, November 2004. http://dx.doi.org/10.32747/2004.7586474.bard.

Full text
Abstract:
Original objectives: The long term objective of the project is to achieve higher content of protein in the milk of ruminants by modulating the translational machinery in the mammary gland. The first specific aim of the BARD proposal was to characterize responsiveness of various experimental systems to combination of lactogenic hormones and amino acids with particular emphasis on discrimination between the control of total protein synthesis and milk protein synthesis. Based on the results, we planned to proceed by characterizing the stage of protein synthesis in which the stimulation by lactogenic hormones and amino acid occur and finally we proposed to identify which components of the translation machinery are modified. Background to the topic: Milk protein is the most valuable component in milk, both for direct human consumption and for manufacturing cheese and other protein-based products. Attempts to augment protein content by the traditional methods of genetic selection and improved nutritional regimes have failed. The proposal was based on recent results suggesting that the limiting factor for augmenting protein synthesis in the bovine mammary gland is the efficiency of converting amino acids to milk proteins. Major conclusions, solutions, achievements: Insulin and prolactin synergistically stimulate â-casein mRNA translation by cytoplasmatic polyadenylation. The interaction between insulin and prolactin was demonstrated two decades ago as crucial for milk-protein synthesis, but the molecular mechanisms involved were not elucidated. We found in differentiated CID 9 mouse mammary epithelial cells line that insulin and prolactin synergistically increases the rate of milk protein mRNA translation. We focused on â-casein, the major milk protein, and found that the increase in â-casein mRNA translation was reflected in a shift to larger polysomes, indicating an effect on translational initiation. Inhibitors of the PI3K, mTOR, and MAPK pathways blocked insulin-stimulated total protein and â-casein synthesis but not the synergistic stimulation. Conversely, cordycepin, a polyadenylation inhibitor, abolished synergistic stimulation of protein synthesis without affecting insulin-stimulated translation. The poly(A) tract of â-casein mRNA progressively increased over 30 min of treatment with insulin plus prolactin. The 3’-untranslated region of â-casein mRNA was found to contain a cytoplasmic polyadenylation element (CPE), and in reporter constructs, this was sufficient for the translational enhancement and mRNA-specific polyadenylation. Furthermore, insulin and prolactin stimulated phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) but did not increase cytoplasmic polyadenylation.
APA, Harvard, Vancouver, ISO, and other styles
8

Varga, Gabriella A., Amichai Arieli, Lawrence D. Muller, Haim Tagari, Israel Bruckental, and Yair Aharoni. Effect of Rumen Available Protein, Amimo Acids and Carbohydrates on Microbial Protein Synthesis, Amino Acid Flow and Performance of High Yielding Cows. United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568103.bard.

Full text
Abstract:
The effect of rumen available protein amino acids and carbohydrates on microbial protein synthesis, amino acid flow and performance of high yielding dairy cows was studied. A significant relationship between the effective degradabilities of OM in feedstuffs and the in vivo ruminal OM degradation of diets of dairy cows was found. The in situ method enabled the prediction of ruminal nutrients degradability response to processing of energy and nitragenous supplements. The AA profile of the rumen undegradable protein was modified by the processing method. In a continuous culture study total N and postruminal AA flows, and bacterial efficiency, is maximal at rumen degradable levels of 65% of the CP. Responses to rumen degradable non carbohydrate (NSC) were linear up to at least 27% of DM. Higher CP flow in the abomasum was found for cows fed high ruminally degradable OM and low ruminally degradable CP diet. It appeared that in dairy cows diets, the ratio of rumen degradable OM to rumenally degradable CP should be at least 5:1 in order to maximize postruminal CP flow. The efficiency of microbial CP synthesis was higher for diets supplemented with 33% of rumen undegradable protein, with greater amounts of bacterial AA reaching the abomasum. Increase in ruminal carbohydrate availability by using high moisture corn increased proportions of propionate, postruminal nutrients flow, postruminal starch digestibility, ruminal availability of NSC, uptake of energy substrates by the mammory gland. These modifications resulted with improvement in the utilization of nonessential AA for milk protein synthesis, in higher milk protein yield. Higher postruminal NSC digestibility and higher efficiency of milk protein production were recorded in cows fed extruded corn. Increasing feeding frequency increased flow of N from the rumen to the blood, reduced diurnal variation in ruminal and ammonia, and of plasma urea and improved postruminal NSC and CIP digestibility and total tract digestibilities. Milk and constituent yield increased with more frequent feeding. In a study performed in a commercial dairy herd, changes in energy and nitrogenous substrates level suggested that increasing feeding frequency may improve dietary nitrogen utilization and may shift metabolism toward more glucogenesis. It was concluded that efficiency of milk protein yield in high producing cows might be improved by an optimization of ruminal and post-ruminal supplies of energy and nitrogenous substrates. Such an optimization can be achieved by processing of energy and nitrogenous feedstuffs, and by increasing feeding frequency. In situ data may provide means for elucidation of the optimal processing conditions.
APA, Harvard, Vancouver, ISO, and other styles
9

Barash, Itamar, and Robert Rhoads. Translational Mechanisms Governing Milk Protein Levels and Composition. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696526.bard.

Full text
Abstract:
Original objectives: The long-term goal of the research is to achieve higher protein content in the milk of ruminants by modulating the translational apparatus of the mammary gland genetically, nutritionally, or pharmacologically. The short-term objectives are to obtain a better understanding of 1) the role of amino acids (AA) as regulators of translation in bovine and mouse mammary epithelial cells and 2) the mechanism responsible for the synergistic enhancement of milk-protein mRNA polyadenylation by insulin and prolactin. Background of the topic: In many cell types and tissues, individual AA affect a signaling pathway which parallels the insulin pathway to modulate rates and levels of protein synthesis. Diverse nutritional and hormonal conditions are funneled to mTOR, a multidomain serine/threonine kinase that regulates a number of components in the initiation and elongation stages of translation. The mechanism by which AA signal mTOR is largely unknown. During the current grant period, we have studied the effect of essential AA on mechanisms involved in protein synthesis in differentiated mammary epithelial cells cultured under lactogenic conditions. We also studied lactogenic hormone regulation of milk protein synthesis in differentiated mammary epithelial cells. In the first BARD grant (2000-03), we discovered a novel mechanism for mRNA-specific hormone-regulated translation, namely, that the combination of insulin plus prolactin causes cytoplasmic polyadenylation of milk protein mRNAs, which leads to their efficient translation. In the current BARD grant, we have pursued the signaling pathways of this novel hormone action. Major conclusions/solutions/achievements: The positive and negative signaling from AA to the mTOR pathway, combined with modulation of insulin sensitization, mediates the synthesis rates of total and specific milk proteins in mammary epithelial cells. The current in vitro study revealed cryptic negative effects of Lys, His, and Thr on cellular mechanisms regulating translation initiation and protein synthesis in mammary epithelial cells that could not be detected by conventional in vivo analyses. We also showed that a signaling pathway involving Jak2 and Stat5, previously shown to lead from the prolactin receptor to transcription of milk protein genes, is also used for cytoplasmic polyadenylation of milk protein mRNAs, thereby stabilizing these mRNAs and activating them for translation. Implications: In vivo, plasma AA levels are affected by nutritional and hormonal effects as well as by conditions of exercise and stress. The amplitude in plasma AA levels resembles that applied in the current in vitro study. Thus, by changing plasma AA levels in the epithelial cell microenvironment or by sensitizing the mTOR pathway to their presence, it should be possible to modulate the rate of milk protein synthesis. Furthermore, knowledge that phosphorylation of Stat5 is required for enhanced milk protein synthesis in response to lactogenic opens the possibility for pharmacologic approaches to increase the phosphorylation of Stat5 and, thereby, milk protein production.
APA, Harvard, Vancouver, ISO, and other styles
10

Paynter, Robin A., Celia Fiordalisi, Elizabeth Stoeger, Eileen Erinoff, Robin Featherstone, Christiane Voisin, and Gaelen P. Adam. A Prospective Comparison of Evidence Synthesis Search Strategies Developed With and Without Text-Mining Tools. Agency for Healthcare Research and Quality (AHRQ), March 2021. http://dx.doi.org/10.23970/ahrqepcmethodsprospectivecomparison.

Full text
Abstract:
Background: In an era of explosive growth in biomedical evidence, improving systematic review (SR) search processes is increasingly critical. Text-mining tools (TMTs) are a potentially powerful resource to improve and streamline search strategy development. Two types of TMTs are especially of interest to searchers: word frequency (useful for identifying most used keyword terms, e.g., PubReminer) and clustering (visualizing common themes, e.g., Carrot2). Objectives: The objectives of this study were to compare the benefits and trade-offs of searches with and without the use of TMTs for evidence synthesis products in real world settings. Specific questions included: (1) Do TMTs decrease the time spent developing search strategies? (2) How do TMTs affect the sensitivity and yield of searches? (3) Do TMTs identify groups of records that can be safely excluded in the search evaluation step? (4) Does the complexity of a systematic review topic affect TMT performance? In addition to quantitative data, we collected librarians' comments on their experiences using TMTs to explore when and how these new tools may be useful in systematic review search¬¬ creation. Methods: In this prospective comparative study, we included seven SR projects, and classified them into simple or complex topics. The project librarian used conventional “usual practice” (UP) methods to create the MEDLINE search strategy, while a paired TMT librarian simultaneously and independently created a search strategy using a variety of TMTs. TMT librarians could choose one or more freely available TMTs per category from a pre-selected list in each of three categories: (1) keyword/phrase tools: AntConc, PubReMiner; (2) subject term tools: MeSH on Demand, PubReMiner, Yale MeSH Analyzer; and (3) strategy evaluation tools: Carrot2, VOSviewer. We collected results from both MEDLINE searches (with and without TMTs), coded every citation’s origin (UP or TMT respectively), deduplicated them, and then sent the citation library to the review team for screening. When the draft report was submitted, we used the final list of included citations to calculate the sensitivity, precision, and number-needed-to-read for each search (with and without TMTs). Separately, we tracked the time spent on various aspects of search creation by each librarian. Simple and complex topics were analyzed separately to provide insight into whether TMTs could be more useful for one type of topic or another. Results: Across all reviews, UP searches seemed to perform better than TMT, but because of the small sample size, none of these differences was statistically significant. UP searches were slightly more sensitive (92% [95% confidence intervals (CI) 85–99%]) than TMT searches (84.9% [95% CI 74.4–95.4%]). The mean number-needed-to-read was 83 (SD 34) for UP and 90 (SD 68) for TMT. Keyword and subject term development using TMTs generally took less time than those developed using UP alone. The average total time was 12 hours (SD 8) to create a complete search strategy by UP librarians, and 5 hours (SD 2) for the TMT librarians. TMTs neither affected search evaluation time nor improved identification of exclusion concepts (irrelevant records) that can be safely removed from the search set. Conclusion: Across all reviews but one, TMT searches were less sensitive than UP searches. For simple SR topics (i.e., single indication–single drug), TMT searches were slightly less sensitive, but reduced time spent in search design. For complex SR topics (e.g., multicomponent interventions), TMT searches were less sensitive than UP searches; nevertheless, in complex reviews, they identified unique eligible citations not found by the UP searches. TMT searches also reduced time spent in search strategy development. For all evidence synthesis types, TMT searches may be more efficient in reviews where comprehensiveness is not paramount, or as an adjunct to UP for evidence syntheses, because they can identify unique includable citations. If TMTs were easier to learn and use, their utility would be increased.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Total synthesis' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography