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1

Yasumura, S., I. E. Stamatelatos, C. N. Boozer, R. Moore, and R. Ma. "In vivo body composition studies in rats: Assessment of total body protein." Applied Radiation and Isotopes 49, no. 5-6 (May 1998): 731–32. http://dx.doi.org/10.1016/s0969-8043(97)00209-1.

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2

De Lorenzo, A., N. Candeloro, I. Bertini, T. Talluri, and L. Pierangeli. "Total body capacity correlated with basal metabolic rate." Applied Radiation and Isotopes 49, no. 5-6 (May 1998): 493–94. http://dx.doi.org/10.1016/s0969-8043(97)00227-3.

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3

Keane, J. T., D. P. Fontenla, and C. S. Chui. "Applications of IMAT to total body radiation (TBI)." International Journal of Radiation Oncology*Biology*Physics 48, no. 3 (January 2000): 239. http://dx.doi.org/10.1016/s0360-3016(00)80274-6.

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4

Quinn, T. J., and J. E. Martin. "A Black-Body Cavity for Total Radiation Thermometry." Metrologia 23, no. 2 (January 1, 1986): 111–14. http://dx.doi.org/10.1088/0026-1394/23/2/004.

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5

Baranov, AE, GD Selidovkin, A. Butturini, and RP Gale. "Hematopoietic recovery after 10-Gy acute total body radiation." Blood 83, no. 2 (January 15, 1994): 596–99. http://dx.doi.org/10.1182/blood.v83.2.596.596.

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Abstract Considerable data suggest that very high doses of acute total body radiation destroy most hematopoietic stem cells and that recovery is possible only after a bone marrow transplant. We review data from a radiation accident victim exposed to about 10-Gy or more acute total body radiation. Total dose and uniformity of distribution were confirmed by physical measurements (paramagnetic resonance), computer simulation, and biologic dosimetry (granulocyte kinetics and cytogenetic abnormalities). Treatment consisted of supportive measures, transfusions, and hematopoietic growth factors (granulocyte-macrophage colony-stimulating factor and interleukin-3). Hematopoietic recovery occurred slowly. Granulocytes were detectable throughout the postexposure period, exceeding 0.5 x 10(9)/L by day 37. There was slower and incomplete recovery of red blood cells and platelets. Increases in blood cell production were paralleled by morphologic changes in bone marrow biopsies. Gastrointestinal toxicity was moderate. Death from a probable radiation pneumonitis infection occurred on day 130. These data indicate the possibility of hematopoietic recovery after approximately 10 Gy or more acute total body radiation without a transplant. They also suggest that lung rather than gastrointestinal toxicity may be dose-limiting under these circumstances.
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6

Baranov, AE, GD Selidovkin, A. Butturini, and RP Gale. "Hematopoietic recovery after 10-Gy acute total body radiation." Blood 83, no. 2 (January 15, 1994): 596–99. http://dx.doi.org/10.1182/blood.v83.2.596.bloodjournal832596.

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Considerable data suggest that very high doses of acute total body radiation destroy most hematopoietic stem cells and that recovery is possible only after a bone marrow transplant. We review data from a radiation accident victim exposed to about 10-Gy or more acute total body radiation. Total dose and uniformity of distribution were confirmed by physical measurements (paramagnetic resonance), computer simulation, and biologic dosimetry (granulocyte kinetics and cytogenetic abnormalities). Treatment consisted of supportive measures, transfusions, and hematopoietic growth factors (granulocyte-macrophage colony-stimulating factor and interleukin-3). Hematopoietic recovery occurred slowly. Granulocytes were detectable throughout the postexposure period, exceeding 0.5 x 10(9)/L by day 37. There was slower and incomplete recovery of red blood cells and platelets. Increases in blood cell production were paralleled by morphologic changes in bone marrow biopsies. Gastrointestinal toxicity was moderate. Death from a probable radiation pneumonitis infection occurred on day 130. These data indicate the possibility of hematopoietic recovery after approximately 10 Gy or more acute total body radiation without a transplant. They also suggest that lung rather than gastrointestinal toxicity may be dose-limiting under these circumstances.
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7

Badawi, Ramsey D., Joel S. Karp, Lorenzo nardo, and Austin R. Pantel. "Total Body PET Imaging." PET Clinics 16, no. 1 (January 2021): i. http://dx.doi.org/10.1016/s1556-8598(20)30086-9.

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8

Chondronikola, Maria, and Souvik Sarkar. "Total-body PET Imaging." PET Clinics 16, no. 1 (January 2021): 75–87. http://dx.doi.org/10.1016/j.cpet.2020.09.001.

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9

Ning, Bingxu, Zhiyuan Hu, Zhengxuan Zhang, Zhangli Liu, Ming Chen, Dawei Bi, and Shichang Zou. "The impact of total ionizing radiation on body effect." Microelectronics Journal 42, no. 12 (December 2011): 1396–99. http://dx.doi.org/10.1016/j.mejo.2011.09.004.

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10

Stewart, F. A. "Radiation Nephropathy after Abdominal Irradiation or Total-Body Irradiation." Radiation Research 143, no. 3 (September 1995): 235. http://dx.doi.org/10.2307/3579208.

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11

Janiszewska, M., K. Polaczek-Grelik, M. Raczkowski, B. Szafron, A. Konefał, and W. Zipper. "Secondary radiation dose during high-energy total body irradiation." Strahlentherapie und Onkologie 190, no. 5 (March 6, 2014): 459–66. http://dx.doi.org/10.1007/s00066-014-0635-z.

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12

Oliveira, F. F., L. L. Amaral, A. M. Costa, and T. G. Netto. "In vivo dosimetry with silicon diodes in total body irradiation." Radiation Physics and Chemistry 95 (February 2014): 230–32. http://dx.doi.org/10.1016/j.radphyschem.2013.02.024.

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13

Belkacémi, Yazid, Mahmut Ozsahin, Françoise Pène, Bernard Rio, Jean-Philippe Laporte, Véronique Leblond, Emmanuel Touboul, Michel Schlienger, Norbert-Claude Gorin, and Alain Laugier. "Cataractogenesis after total body irradiation." International Journal of Radiation Oncology*Biology*Physics 35, no. 1 (April 1996): 53–60. http://dx.doi.org/10.1016/s0360-3016(96)85011-5.

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14

Rundo, J., and Mogens Faber. "Total-body γ-radiation from patients with internally deposited thorium." Recueil des Travaux Chimiques des Pays-Bas 74, no. 4 (September 2, 2010): 416–22. http://dx.doi.org/10.1002/recl.19550740406.

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15

Fu, Hanjiang, Yong Xue, Fei Su, Kexin Ding, Yuan Wang, Haiyue Yu, Jie Zhu, Qing Li, Changhui Ge, and Xiaofei Zheng. "Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice." Dose-Response 18, no. 2 (April 1, 2020): 155932582092014. http://dx.doi.org/10.1177/1559325820920141.

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During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment, is especially important. To address this and find plasma biomarkers to assess ionizing radiation-induced mortality in the early stages, mice were administered a whole-body lethal dose of γ radiation, and radiation-induced damage was evaluated. Multiple blood biomarkers were screened using an antibody array, followed by validation using enzyme-linked immunoassay. The results revealed that irradiation (IR)-induced mortality in mice and caused body weight and blood platelet losses in deceased mice compared to surviving mice. The levels of certain proteins differed after IR between these 2 groups. Specific proteins in preirradiated mice were also found to potentiate radiosensitivity. Plasma levels of interleukin (IL)-22, urokinase, resistin, and IL-6 were associated with radiation-induced mortality in irradiated mice and may be useful as potential mortality predictors. Our results suggest that estimating the levels of certain plasma proteins is a promising alternative to conventional cytogenetic biodosimetry to accurately identify individuals exposed to high radiation doses and those at risk of death due to exposure. This strategy would facilitate the rapid triage of individuals requiring immediate and intensive medical treatment.
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16

Obcemea, Ceferino H., Roger K. Rice, Bernard J. Mijnheer, Robert L. Siddon, Nancy J. Tarbell, Peter Mauch, and Lee M. Chin. "Three-dimensional dose distribution of total body irradiation by a dual source total body irradiator." International Journal of Radiation Oncology*Biology*Physics 24, no. 4 (January 1992): 789–93. http://dx.doi.org/10.1016/0360-3016(92)90730-6.

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17

Gale, R. P., and F. O. Hoffman. "Communicating cancer risk from radiation exposures: nuclear accidents, total body radiation and diagnostic procedures." Bone Marrow Transplantation 48, no. 1 (October 29, 2012): 2–3. http://dx.doi.org/10.1038/bmt.2012.90.

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18

Gordon, Christopher J. "Normalizing the thermal effects of radiofrequency radiation: Body mass versus total body surface area." Bioelectromagnetics 8, no. 2 (1987): 111–18. http://dx.doi.org/10.1002/bem.2250080202.

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19

Badawi, Ramsey D., Joel S. Karp, Lorenzo Nardo, and Austin R. Pantel. "Total Body PET: Exploring New Horizons." PET Clinics 16, no. 1 (January 2021): xvii—xviii. http://dx.doi.org/10.1016/j.cpet.2020.09.005.

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20

Sproull, Mary, Tamalee Kramp, Anita Tandle, Uma Shankavaram, and Kevin Camphausen. "Multivariate Analysis of Radiation Responsive Proteins to Predict Radiation Exposure in Total-Body Irradiation and Partial-Body Irradiation Models." Radiation Research 187, no. 2 (January 1, 2017): 251. http://dx.doi.org/10.1667/rr14558.1.

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21

Brown, D. W., A. Hussain, J. E. Villarreal-Barajas, and P. Dunscombe. "Aperture Modulated, Translational Total Body Irradiation." International Journal of Radiation Oncology*Biology*Physics 78, no. 3 (November 2010): S813. http://dx.doi.org/10.1016/j.ijrobp.2010.07.1883.

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22

Borg, Martin, Timothy Hughes, Noemi Horvath, Michael Rice, and Anthony C. Thomas. "Renal toxicity after total body irradiation." International Journal of Radiation Oncology*Biology*Physics 54, no. 4 (November 2002): 1165–73. http://dx.doi.org/10.1016/s0360-3016(02)03039-0.

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23

Vriesendorp, H. M., M. G. Herman, and R. Saral. "Future analyses of total body irradiation." International Journal of Radiation Oncology*Biology*Physics 20, no. 3 (March 1991): 635–37. http://dx.doi.org/10.1016/0360-3016(91)90082-f.

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24

Maghsoudi, K., O. Morin, J. Pouliot, J. Chang, J. Johnson, A. Polishchuk, and S. Fogh. "Dosimetric Considerations of Total Body Irradiation." International Journal of Radiation Oncology*Biology*Physics 87, no. 2 (October 2013): S746. http://dx.doi.org/10.1016/j.ijrobp.2013.06.1977.

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25

Marie, S. M., V. Passerat, C. Pästeuris, and C. Carrie. "Late Toxicities after Total Body Irradiation." International Journal of Radiation Oncology*Biology*Physics 75, no. 3 (November 2009): S515. http://dx.doi.org/10.1016/j.ijrobp.2009.07.1175.

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26

Rodgers, Kathleen E., Theresa Espinoza, Norma Roda, Christopher J. Meeks, Colin Hill, Stan G. Louie, and Gere S. Dizerega. "Accelerated hematopoietic recovery with angiotensin-(1–7) after total body radiation." International Journal of Radiation Biology 88, no. 6 (April 30, 2012): 466–76. http://dx.doi.org/10.3109/09553002.2012.676228.

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27

Halper, Shelley, and Maria Medinica. "Porokeratosis in a patient treated with total body electron beam radiation." Journal of the American Academy of Dermatology 23, no. 4 (October 1990): 754–55. http://dx.doi.org/10.1016/s0190-9622(08)81078-x.

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28

Takenaka, Ryosuke, Hideomi Yamashita, Takashi Toya, Akihiro Haga, Shino Shibata, Mineo Kurokawa, Kuni Ootomo, and Keiichi Nakagawa. "Unique radiation dermatitis related to total body irradiation by helical tomotherapy." Journal of Dermatology 43, no. 11 (April 30, 2016): 1376–77. http://dx.doi.org/10.1111/1346-8138.13396.

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29

Rohner, Deborah J., Suzanne Bennett, Chandrasiri Samaratunga, Elizabeth S. Jewell, Jeffrey P. Smith, Mary Gaskill-Shipley, and Steven J. Lisco. "Cumulative Total Effective Whole-Body Radiation Dose in Critically Ill Patients." Chest 144, no. 5 (November 2013): 1481–86. http://dx.doi.org/10.1378/chest.12-2222.

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30

Janowski, Einsley, and Anatoly Dritschilo. "Radiation Sensitization of Leukemic Cells for Low Dose Total Body Irradiation." EBioMedicine 2, no. 4 (April 2015): 278–79. http://dx.doi.org/10.1016/j.ebiom.2015.03.011.

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31

Kirova, YM, H. Rafi, M.-C. Voisin, C. Rieux, M. Kuentz, SLe Mouel, E. Levy, and C. Cordonnier. "Radiation-induced bone sarcoma following total body irradiation: role of additional radiation on localized areas." Bone Marrow Transplantation 25, no. 9 (April 26, 2000): 1011–13. http://dx.doi.org/10.1038/sj.bmt.1702381.

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32

Henrich, Timothy J., Terry Jones, Denis Beckford-Vera, Patricia M. Price, and Henry F. VanBrocklin. "Total-Body PET Imaging in Infectious Diseases." PET Clinics 16, no. 1 (January 2021): 89–97. http://dx.doi.org/10.1016/j.cpet.2020.09.011.

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33

Chaudhari, Abhijit J., William Y. Raynor, Ali Gholamrezanezhad, Thomas J. Werner, Chamith S. Rajapakse, and Abass Alavi. "Total-Body PET Imaging of Musculoskeletal Disorders." PET Clinics 16, no. 1 (January 2021): 99–117. http://dx.doi.org/10.1016/j.cpet.2020.09.012.

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34

Mason, Kathy A., H. Rodney Withers, William H. McBride, Cally A. Davis, and James B. Smathers. "Comparison of the Gastrointestinal Syndrome after Total-Body or Total-Abdominal Irradiation." Radiation Research 117, no. 3 (March 1989): 480. http://dx.doi.org/10.2307/3577353.

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35

Zhao, Yu, Junling Zhang, Xiaodan Han, and Saijun Fan. "Total body irradiation induced mouse small intestine senescence as a late effect." Journal of Radiation Research 60, no. 4 (June 5, 2019): 442–50. http://dx.doi.org/10.1093/jrr/rrz026.

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Abstract Radiation can induce senescence in many organs and tissues; however, it is still unclear how radiation stimulates senescence in mouse small intestine. In this study, we use the bone marrow transplantation mouse model to explore the late effects of total body irradiation on small intestine. Our results showed that almost all of the body hairs of the irradiated mice were white (which is an indication of aging) 10 months after the exposure to radiation. Furthermore, compared with the age-matched control mice, there were more SA-β-galactosidase (SA-β-gal)–positive cells and an upregulation of p16 and p21 in 8 Gy–irradiated mice intestinal crypts, indicating that radiation induced senescence in the small intestine. Intestinal bacterial flora profile analysis showed that the diversity of the intestinal bacterial flora decreased in irradiated mice; in addition it showed that the principal components of the irradiated and control mice differed: there was increased abundance of Bacteroidia and a decreased abundance of Clostridia in irradiated mice. To explore the underlying mechanism, an RNA-sequence was executed; the results suggested that pancreatic secretion, and the digestion and absorption of proteins, carbohydrates, fats and vitamins were damaged in irradiated mice, which may be responsible for the body weight loss observed in irradiated mice. In summary, our study suggested that total body irradiation may induce senescence in the small intestine and damage the health status of the irradiated mice.
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36

Barker, C. A., A. Rimner, and J. Yahalom. "A Century of Total Body Irradiation (TBI)." International Journal of Radiation Oncology*Biology*Physics 75, no. 3 (November 2009): S434—S435. http://dx.doi.org/10.1016/j.ijrobp.2009.07.995.

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37

Lawton, Colleen A. "Total body irradiation for bone marrow transplantation." International Journal of Radiation Oncology*Biology*Physics 42, no. 1 (January 1998): 104. http://dx.doi.org/10.1016/s0360-3016(98)80035-7.

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38

Donnall Thomas, E. "Total body irradiation regimens for marrow grafting." International Journal of Radiation Oncology*Biology*Physics 19, no. 5 (November 1990): 1285–88. http://dx.doi.org/10.1016/0360-3016(90)90245-f.

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39

Shank, Brenda M. "Total body irradiation for bone marrow transplantation." International Journal of Radiation Oncology*Biology*Physics 27 (1993): 106. http://dx.doi.org/10.1016/0360-3016(93)90588-m.

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40

Pierce, Greg, Alex Balogh, Rebecca Frederick, Deborah Gordon, Adam Yarschenko, and Alana Hudson. "Extended SSD VMAT treatment for total body irradiation." Journal of Applied Clinical Medical Physics 20, no. 1 (December 27, 2018): 200–211. http://dx.doi.org/10.1002/acm2.12519.

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41

Sarfaraz, Mehrdad, Cedric Yu, D. J. Chen, and Leon Der. "A translational couch technique for total body irradiation." Journal of Applied Clinical Medical Physics 2, no. 4 (September 2001): 201–9. http://dx.doi.org/10.1120/jacmp.v2i4.2597.

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42

Kazadzis, S., A. Bais, M. Blumthaler, A. Webb, N. Kouremeti, R. Kift, B. Schallhart, and A. Kazantzidis. "Effects of total solar eclipse of 29 March 2006 on surface radiation." Atmospheric Chemistry and Physics 7, no. 22 (November 22, 2007): 5775–83. http://dx.doi.org/10.5194/acp-7-5775-2007.

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Abstract. Solar irradiance spectral measurements were performed during a total solar eclipse. The spectral effect of the limb darkening to the global, direct irradiance and actinic flux measurements was investigated. This effect leads to wavelength dependent changes in the measured solar spectra showing a much more pronounced decrease in the radiation at the lower wavelengths. Radiative transfer model results were used for the computation of a correction for the total ozone measurements due to the limb darkening. This correction was found too small to explain the large decrease in total ozone column derived from the standard Brewer measurements, which is an artifact in the measured irradiance due to the increasing contribution of diffuse radiation against the decreasing direct irradiance caused by the eclipse. Calculations of the Extraterrestrial spectrum and the effective sun's temperatures, as measured from ground based direct irradiance measurements, showed an artificial change in the calculations of both quantities due to the fact that radiation coming from the visible part of the sun during the eclipse phases differs from the black body radiation described by the Planck's law.
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43

Kazadzis, S., A. Bais, M. Blumthaler, A. Webb, N. Kouremeti, R. Kift, B. Schallhart, and A. Kazantzidis. "Effects of total solar eclipse of 29 March 2006 on surface radiation." Atmospheric Chemistry and Physics Discussions 7, no. 3 (June 29, 2007): 9235–58. http://dx.doi.org/10.5194/acpd-7-9235-2007.

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Abstract. Solar irradiance spectral measurements were performed during a total solar eclipse. The spectral effect of the limb darkening to the global, direct irradiance and actinic flux measurements was investigated. This effect leads to wavelength dependent changes in the measured solar spectra showing a much more pronounced decrease in the radiation at the lower wavelengths. Radiative transfer model results were used for the computation of a correction for the total ozone measurements due to the limb darkening. This correction was found too small to explain the large decrease in total ozone column derived from the standard Brewer measurements, which is an artifact in the measured irradiance due to the increasing contribution of diffuse radiation against the decreasing direct irradiance caused by the eclipse. Calculations of the Extraterrestrial spectrum and the effective sun's temperatures, as measured from ground based direct irradiance measurements, showed an artificial change in the calculations of both quantities due to the fact that radiation coming from the visible part of the sun during the eclipse phases differs from the back body radiation described by the Planck's law.
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44

Sabloff, Mitchell, Steven Tisseverasinghe, Mustafa Ege Babadagli, and Rajiv Samant. "Total Body Irradiation for Hematopoietic Stem Cell Transplantation: What Can We Agree on?" Current Oncology 28, no. 1 (February 14, 2021): 903–17. http://dx.doi.org/10.3390/curroncol28010089.

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Total body irradiation (TBI), used as part of the conditioning regimen prior to allogeneic and autologous hematopoietic cell transplantation, is the delivery of a relatively homogeneous dose of radiation to the entire body. TBI has a dual role, being cytotoxic and immunosuppressive. This allows it to eliminate disease and create “space” in the marrow while also impairing the immune system from rejecting the foreign donor cells being transplanted. Advantages that TBI may have over chemotherapy alone are that it may achieve greater tumour cytotoxicity and better tissue penetration than chemotherapy as its delivery is independent of vascular supply and physiologic barriers such as renal and hepatic function. Therefore, the so-called “sanctuary” sites such as the central nervous system (CNS), testes, and orbits or other sites with limited blood supply are not off-limits to radiation. Nevertheless, TBI is hampered by challenging logistics of administration, coordination between hematology and radiation oncology departments, increased rates of acute treatment-related morbidity and mortality along with late toxicity to other tissues. Newer technologies and a better understanding of the biology and physics of TBI has allowed the field to develop novel delivery systems which may help to deliver radiation more safely while maintaining its efficacy. However, continued research and collaboration are needed to determine the best approaches for the use of TBI in the future.
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45

Ossetrova, Natalia I., Patrick H. Ney, Donald P. Condliffe, Katya Krasnopolsky, and Kevin P. Hieber. "Acute Radiation Syndrome Severity Score System in Mouse Total-Body Irradiation Model." Health Physics 111, no. 2 (August 2016): 134–44. http://dx.doi.org/10.1097/hp.0000000000000499.

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46

Azimzadeh, Omid, Harry Scherthan, Hakan Sarioglu, Zarko Barjaktarovic, Marcus Conrad, Andreas Vogt, Julia Calzada-Wack, et al. "Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation." PROTEOMICS 11, no. 16 (July 27, 2011): 3299–311. http://dx.doi.org/10.1002/pmic.201100178.

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47

Cui, Wanchang, Jinfang Ma, Yulei Wang, and Shyam Biswal. "Plasma miRNA as Biomarkers for Assessment of Total-Body Radiation Exposure Dosimetry." PLoS ONE 6, no. 8 (August 17, 2011): e22988. http://dx.doi.org/10.1371/journal.pone.0022988.

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48

Wong, Jeffrey Y. C., Andrea Riccardo Filippi, Bouthaina Shbib Dabaja, Joachim Yahalom, and Lena Specht. "Total Body Irradiation: Guidelines from the International Lymphoma Radiation Oncology Group (ILROG)." International Journal of Radiation Oncology*Biology*Physics 101, no. 3 (July 2018): 521–29. http://dx.doi.org/10.1016/j.ijrobp.2018.04.071.

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49

Cunha, J. S., D. N. Souza, and A. B. Carvalho Júnior. "Dose calculation with MCNPX code for Total Body Irradiation technique in sitting and lying postures." Radiation Physics and Chemistry 149 (August 2018): 1–6. http://dx.doi.org/10.1016/j.radphyschem.2018.03.004.

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50

Rodriguez, Jose A., Senthil Selvaraj, and Paco E. Bravo. "Potential Cardiovascular Applications of Total-body PET Imaging." PET Clinics 16, no. 1 (January 2021): 129–36. http://dx.doi.org/10.1016/j.cpet.2020.09.004.

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