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Audibert, G., C. Charpentier, J. Garric, P. Welfringer, and M. C. Laxenaire. "Difference Arterio-Veineuse En CO2 Et Tonometrie Gastrique Au Cours Du Choc Hemorragique Chez Le Polytraumatise." Annales Françaises d'Anesthésie et de Réanimation 14 (January 1995): R190. http://dx.doi.org/10.1016/s0750-7658(05)81224-9.
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Kolchina, М. А., O. V. Kosmatova, V. E. Novikov, and I. A. Skripnikova. "Early markers of athrosclerotic cardiovascular diseases and osteoporotic fractures in a postmenopausal woman (сlinical case)." Clinician 13, no. 3-4 (January 30, 2020): 53–58. http://dx.doi.org/10.17650/1818-8338-2019-13-3-4-53-58.
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The aim to demonstrate that subclinical atherosclerosis and vascular rigidity in a postmenopausal patient without clinical sings of cardiovascular disease and osteoporosis are connected with a decreased bone mass.Materials and methods. Patient O., 64 years old, was examined at the National Medical Research Center for Preventive Medicine within the program “Comprehensive assessment of total risks and early preclinical markers of osteoporosis and atherosclerosis complications”. No complaints during the examination were revealed. Laboratory tests were performed to evaluate blood lipids level, calcium-phosphorus metabolism, determine marker of bone resorption – CTX (β-crosslaps), measure levels of vitamin D and parathyroid hormone. Instrumental examinations included dual-energy x-ray absorptiometry of the spine and femoral neck, carotid ultrasound, applanation tonometry, multispiral computed tomography of coronary arteries with calcium score determination.Results. During outpatient examination, densitometry revealed decreased bone mineral density in the lumbar spine and in the femoral neck, corresponding to osteoporosis, carotid ultrasound identified atherosclerotic plaques, multispiral computed tomography of coronary arteries – coronary calcification, applanation tonometry – increased aortic stiffness.Conclusion. The clinical case is an example of early-detected preclinical signs of atherosclerosis and osteoporosis, as well as an increased risk of cardiovascular complications. Due to the high frequency of subclinical atherosclerosis, vessel wall state should be examined in women at the beginning of postmenopause. Signs of vascular stiffness and subclinical atherosclerosis give occasion to assess risk of fractures using the FRAX ® calculator and, if necessary, to diagnose bone mass loss using X-ray densitometry. Proposed algorithm can contribute to the early detection of cardiovascular diseases and at the same time improve fracture risk assessment.
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Zion, A. "Evaluation of blood pressure and baroreflex sensitivity by radial artery tonometry versus finger arteriolar photoplethysmography." American Journal of Hypertension 16, no. 5 (May 2003): 371–74. http://dx.doi.org/10.1016/s0895-7061(03)00039-6.
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Salyamova, Ludmila I., Angelina A. Khromova, Olga G. Kvasova, Irina V. Avdeeva, Natalia A. Borisova, Karina N. Korenkova, Kristina N. Polezhaeva, and Valentin E. Oleynikov. "Vasoprotective effect of effective lipid-lowering therapy in patients with <i>ST</i>-segment elevation myocardial infarction." Terapevticheskii arkhiv 94, no. 12 (January 16, 2023): 1355–60. http://dx.doi.org/10.26442/00403660.2022.12.202007.
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Aim. To study the vasoprotective effects of atorvastatin depending on the achievement of the target level of low-density lipoprotein cholesterol (LDL-C) in patients with ST-segment elevation myocardial infarction (STEMI) within 48 weeks of follow-up.
Materials and methods. Included were 112 STEMI patients who received atorvastatin 204080 mg. On days 79 from the onset of the disease, after 24 and 48 weeks, ultrasound examination of the carotid arteries with RF technology and applanation tonometry were performed, the lipid profile was determined. The patients were divided into groups: group 1 (n=41) of highly effective therapy (HET) who achieved the target LDL-C after 24 and 48 weeks; group 2 (n=29) in relatively effective therapy (RET) achieving target values at 24th or 48th week; group 3 (n=42) insufficiently effective therapy (IET) did not reach the target LDL-C.
Results. When examining the carotid arteries in the HET group, the intima-media thickness (IMT) decreased by 10.713.1%, the b index by 14.926.3% after 2448 weeks. In the RET group, the IMT regression was 10.413.3%; b index 23.9% by the 48th week. In the IET group, the b index decreased by the 48th week by 14.3%. According to applanation tonometry in the HET group, the central pressure did not change. In the RET group, systolic pressure in the aorta increased by 1015.7% after 2448 weeks, pulse pressure by 33.9% by the end of observation. With IET, the increase was 8.66.8 and 19.825.9%, respectively. The odds ratio of developing endpoints in the RET group was 4.7 (95% CI 1.226.4; p=0.02), in the IET group 3.9 (95% CI 1.124.8; p=0.03) compared with HET.
Conclusion. The most pronounced vasoprotective effect and a decrease in cardiovascular risk are associated with the achievement of the target LDL-C throughout the entire treatment period.
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Chopoorian, Abby H., Amr Wahba, Jorge Celedonio, Victor Nwazue, Emily C. Smith, Emily M. Garland, Sachin Paranjape, et al. "Impaired Endothelial Function in Patients With Postural Tachycardia Syndrome." Hypertension 77, no. 3 (March 3, 2021): 1001–9. http://dx.doi.org/10.1161/hypertensionaha.120.16238.
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The purpose of this study is to evaluate endothelial function in postural tachycardia syndrome (PoTS), a poorly understood chronic condition characterized by a state of consistent orthostatic tachycardia (delta heart rate ≥30 beats per minute) upon standing without orthostatic hypotension. Nineteen patients with PoTS and 9 healthy controls were studied after 3 days of a fixed, caffeine-free, normal sodium (150 milliequivalents/day) diet. All participants underwent autonomic function testing, including sinus arrhythmia, valsalva maneuver, hyperventilation, cold pressor, handgrip, and a standing test with catecholamine measurements, followed by endothelial function testing. We analyzed 3 measures of endothelial function: percent brachial flow-mediated dilation, digital pulsatile arterial tonometry, and postischemic percent leg blood flow. Flow-mediated dilation was significantly lower in patients with PoTS (6.23±3.54% for PoTS) than in healthy controls (10.6±4.37% for controls versus, P =0.014). PoTS and controls had similar digital pulsatile arterial tonometry (1.93±0.40 arbitrary units for controls versus 2.13±0.63 arbitrary units for PoTS). PoTS had similar but suggestive percent leg blood flow to controls (313±158% for PoTS versus 468±236% for controls, P =0.098). Patients with PoTS have significantly reduced flow-mediated dilation compared with healthy controls, suggesting that PoTS is characterized by endothelial dysfunction in conduit arteries. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01308099.
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Faulkner, Josephine, David Leonard Williams, and Karin Mueller. "Ophthalmology of clinically normal alpacas (Vicugna pacos) in the United Kingdom: a cross-sectional study." Veterinary Record 186, no. 16 (April 17, 2020): e7-e7. http://dx.doi.org/10.1136/vr.105758.
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BackgroundAlpacas are being more frequently presented to veterinarians in the UK. It is important to validate whether published normal ocular parameters are consistent with the alpaca population in the UK.MethodsOphthalmic examinations were performed on healthy alpacas (Vicugna pacos) from three farms in East Anglia, UK.ResultsOn direct ophthalmoscopy of 35 alpacas, there was a 50 per cent prevalence of opacities within the lens in alpacas older than two years old (n=8/16). There was a 36.8 per cent prevalence of persistent hyaloid arteries in alpacas under two years old (n=7/19). The mean Schirmer tear test-1 value was 20.0 ±6 mm/minute (n=40). The mean intraocular pressure measured by rebound tonometry was 17.2 ±5.5 mmHg (n=46), and applanation tonometry resulted in statistically similar values (P=0.30; n=25). There was a significant variation in intraocular pressure throughout a 24-hour period (n=8). Fluorescein dye was not detected at the nostrils of any of the alpacas which underwent a Jones test to assess nasolacrimal duct patency (n=8).ConclusionThe ophthalmic findings appear largely consistent with previously published values from North America and continental Europe. Variations include the large range of measurements obtained and evidence of diurnal variation in intraocular pressure.
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Zambanini, A., S. L. Cunningham, K. H. Parker, A. W. Khir, S. A. McG. Thom, and A. D. Hughes. "Wave-energy patterns in carotid, brachial, and radial arteries: a noninvasive approach using wave-intensity analysis." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 1 (July 2005): H270—H276. http://dx.doi.org/10.1152/ajpheart.00636.2003.
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The study of wave propagation at different points in the arterial circulation may provide useful information regarding ventriculoarterial interactions. We describe a number of hemodynamic parameters in the carotid, brachial, and radial arteries of normal subjects by using noninvasive techniques and wave-intensity analysis (WIA). Twenty-one normal adult subjects (14 men and 7 women, mean age 44 ± 6 yr) underwent applanation tonometry and pulsed-wave Doppler studies of the right common carotid, brachial, and radial arteries. After ensemble averaging of the pressure and flow-velocity data, local hydraulic work was determined and a pressure-flow velocity loop was used to determine local wave speed. WIA was then applied to determine the magnitude, timings, and energies of individual waves. At all sites, forward-traveling (S) and backward-traveling (R) compression waves were observed in early systole. In mid- and late systole, forward-traveling expansion waves (X and D) were also seen. Wave speed was significantly higher in the brachial (6.97 ± 0.58 m/s) and radial (6.78 ± 0.62 m/s) arteries compared with the carotid artery (5.40 ± 0.34 m/s; P < 0.05). S-wave energy was greatest in the brachial artery (993.5 ± 87.8 mJ/m2), but R-wave energy was greatest in the radial artery (176.9 ± 19.9 mJ/m2). X-wave energy was significantly higher in the brachial and radial arteries (176.4 ± 32.7 and 163.2 ± 30.5 mJ/m2, respectively) compared with the carotid artery (41.0 ± 9.4 mJ/m2; P < 0.001). WIA illustrates important differences in wave patterns between peripheral arteries and may provide a method for understanding ventriculo-arterial interactions in the time domain.
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Palombo, Carlo, Carmela Morizzo, Martino Baluci, Daniela Lucini, Stefano Ricci, Gianni Biolo, Piero Tortoli, and Michaela Kozakova. "Large Artery Remodeling and Dynamics following Simulated Microgravity by Prolonged Head-Down Tilt Bed Rest in Humans." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/342565.
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The effects of simulated microgravity on the static and dynamic properties of large arteries are still mostly unknown. The present study evaluated, using an integrated vascular approach, changes in structure and function of the common carotid and femoral arteries (CCA and CFA) after prolonged head-down tilt bed rest (HDTBR). Ten healthy men were enrolled in a 5-week HDTBR study endorsed by the Italian Space Agency (ASI). Arterial geometry, flow, stiffness, and shear rate were evaluated by ultrasound. Local carotid pulse pressure and wave reflection were studied by applanation tonometry. After five weeks of HDTBR, CFA showed a decrease in lumen diameter without significant changes in wall thickness (IMT), resulting in an inward remodeling. Local carotid pulse pressure decreased and carotid-to-brachial pressure amplification increased. The ratio of systolic-to-diastolic volumetric flow in CFA decreased, whereas in CCA it tended to increase. Indices of arterial stiffness and shear rate did not change during HDTBR, either in CCA or CFA. In summary, prolonged HDTBR has a different impact on CCA and CFA structure and flow, probably depending on the characteristics of the vascular bed perfused.
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Davison, Kade, Stefan Bircher, Alison Hill, Alison M. Coates, Peter R. C. Howe, and Jonathan D. Buckley. "Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function." Journal of Obesity 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/191253.
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Background. Obesity and low cardiorespiratory fitness (CRF) have been shown to independently increase the risk of CVD mortality. The aim of this study was to investigate the relationship between CRF, body fatness and markers of arterial function.Method and Results. Obese (9 male, 18 female; BMI 35.3 ± 0.9 kg·m-2) and lean (8 male, 18 female; BMI 22.5 ± 0.3 kg·m-2) volunteers were assessed for body composition (DXA), cardiorespiratory fitness (predicted max), blood pressure (BP), endothelial vasodilatator function (FMD), and arterial compliance (AC) (via radial artery tonometry). The obese group had more whole body fat and abdominal fat (43.5 ± 1.2% versus 27.2 ± 1.6%; and 48.6 ± 0.9% versus 28.9 ± 1.8%; resp.), and lower FMD (3.2 ± 0.4% versus 5.7 ± 0.7%; ) than the lean subjects, but there was no difference in AC. AC in large arteries was positively associated with CRF (; ) but not with fatness.Conclusion. These results indicate distinct influences of obesity and CRF on blood vessel health. FMD was impaired with obesity, which may contribute to arterial and metabolic dysfunction. Low CRF was associated with reduced elasticity in large arteries, which could result in augmentation of aortic afterload.
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Shchelkova, G. V., A. R. Zairova, N. M. Danilov, A. N. Rogoza, and I. E. Chazova. "Effect of renal denervation on the arterial stiffness and central hemodynamics in patients with resistant hypertension." Systemic Hypertension 13, no. 4 (December 15, 2016): 7–12. http://dx.doi.org/10.26442/sg29140.
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Aim: to evaluate the effect of renal denervation (RDN) on the stiffness of the aorta and major arteries, central blood pressure and index augmentation in patients with resistant hypertension. Material and methods. We included 20 patients with systolic blood pressure 178 [170; 180] mm Hg and diastolic blood pressure 100 [94; 100] mm Hg on 5.1±0.7 antihypertensive drugs with diuretic, who underwent bilateral RDN. Blood pressure (BP) was studied before intervention, at 7 days and 6 months after RDN by tree methods: office BP, 24-hour ambulatory blood pressure (ABPM) and aortic BP with applanation tonometry a. radialis (SphygmoCor). All patients were divided into two groups by ABPM in 6 months after RDN: responders (decrease of mean ABPM≥5 mm Hg) and non-responders (decrease of mean ABPM
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Elka, Kana, Monique Rotty, Johan Winata, Janry Pangemanan, and A. Lucia Panda. "The Pulse Wave Velocity is Linearly Correlated with Resting Systolic and Diastolic Blood Pressure in Hypertensive Patients." Indonesian Journal of Cardiology 39, no. 1 (August 21, 2018): 15–21. http://dx.doi.org/10.30701/ijc.v39i1.791.
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Introduction: Aortic stiffness is an independent predictor for cardiovascular event. If arteries lose their natural elasticity, systolic blood pressure become higher and diastolic blood pressure become lower. Method of evaluating arterial stiffness is aortic pulse wave velocity (PWV). Therefore, PWV has a potential application for screening vascular damage in large population.2 Recent reports have shown that PWV obtained by noninvasive automatic devices (i.e. tonometry, cuff pressure) is not only a marker of vascular damages, but also a prognostic predictor in patients with hypertension.3 The aim of this study is to investigate the correlation between PWV and systolic and diastolic blood pressure.
Methods : Male hypertensive patients, aged 40-60 years old who underwent Doppler Vascular were included in this study. The measurement of carotid-femoral PWV is made by dividing the distance (from the carotid point to the femoral point) by the so-called transit time (the time of travel of the foot of the wave over the distance). Hence, PWV = D (meters)/Dt (seconds). The correlation between PWV and systolic and diastolic blood pressure were analysed using linear regression test.
Results : A total 40 patients were included in this study. Those were significant correlation between PWV and systolic (R=0.473, p=0.002) and diastolic (R=0.454, p=0.003) blood pressure.
Conclusion : increasing PWV is linearly associated with systolic and diastolic blood pressure.
Abstrak
Pendahuluan: Kekakuan aorta adalah prediktor independen untuk kejadian kardiovaskular. Jika elastisitas alami arteri hilang, tekanan darah sistolik menjadi lebih tinggi dan tekanan darah diastolik menjadi lebih rendah. Metode evaluasi kekakuan arteri adalah kecepatan gelombang pulsasi (pulse wave velocity/PWV). Oleh karena itu, PWV dapat diterapkan untuk skrining kerusakan vaskular pada populasi besar.2 Laporan terbaru menunjukkan bahwa PWV yang diperoleh dengan perangkat otomatis non-invasif (yaitu tonometri, tekanan manset) tidak hanya merupakan penanda kerusakan vaskular, tetapi juga prediktor prognostik pada pasien dengan hipertensi.3 Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara PWV dan tekanan darah sistolik dan diastolik.
Metode: Pasien pria dengan hipertensi, berusia 40-60 tahun yang menjalani Doppler Vascular dimasukkan dalam penelitian ini. Pengukuran PWV karotid-femoralis dilakukan dengan membagi jarak (dari titik karotid ke titik femoral) dengan waktu transit. Oleh karena itu, PWV = D (meter) / Dt (detik). Korelasi antara tekanan darah PWV dan sistolik dan diastolik dianalisis dengan menggunakan uji regresi linier.
Hasil: Sebanyak 40 pasien dimasukkan dalam penelitian ini. Itu adalah korelasi yang signifikan antara tekanan darah PWV dan sistolik (R = 0,473, p = 0,002) dan diastolik (R = 0,454, p = 0,003).
Kesimpulan: Peningkatan PWV berhubungan linear dengan tekanan darah sistolik dan diastolik.
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Ikezono, Etsutaro, Tetsuo Ikezono, and John Ackerman. "Establishing the Existence of the Active Stomach Point in the Auricle Utilizing Radial Artery Tonometry." American Journal of Chinese Medicine 31, no. 02 (January 2003): 285–94. http://dx.doi.org/10.1142/s0192415x03000928.
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One component of Oriental medicine diagnosis utilizes the palpation of the radial pulse both for internal medicine and also to help clinicians accurately choose body acupuncture treatment points. In the mid-1980s, an attempt was made to capture diagnostic information with three pressure transducers positioned bilaterally over the radial arteries in such a fashion as to simulate classical Chinese pulse diagnosis (Yoon and Ikezono, 1986 and 1987). The results of this pilot study were subsequently difficult to replicate. In the early 1950s, Paul Nogier in Lyon, France introduced a different pulse diagnostic technique (Nogier, 1976). By touching an acupuncture needle on an active auricular acupuncture point, the radial artery wall over the styloid process changes in tone more prominently than when inactive points on the acuricle are touched. This dermal/cardiovascular reflex of pulse diagnostic technique helps, then to localize salient auricular points to treat regarding a patient's illness. Objective digitalized measurements of the Nogier radial arterial pulse wave were performed by computerized tonometry. This demonstrated that when an active stomach point in the auricle (n = 11) was detected utilizing an imperceptible electric current, the initial upstroke of the pressure wave, the pulse pressure and the peak-to-peak interval of the radial artery pulse wave all increased significantly compared to placebo point electronic detection. Thus, the existence of an active auricular point on the auricle was verified by radial artery tonometry.
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de Hoon, JN, JM Willigers, J. Troost, HA Struijker-Boudier, and LM Van Bortel. "Cranial and Peripheral Interictal Vascular Changes in Migraine Patients." Cephalalgia 23, no. 2 (March 2003): 96–104. http://dx.doi.org/10.1046/j.1468-2982.2003.00465.x.
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As migraine is associated with an increased risk for ischaemic stroke and peripheral vasospastic disorders, it was hypothesized that interictal vascular changes may be present in migraine patients. Using ultrasound and applanation tonometry, the cardiovascular properties of migraine patients were compared with those of matched control subjects. Vascular parameters of the carotid arteries, cardiac output and systemic vascular resistance did not differ between both groups. Right temporal artery diameter was larger in migraine patients (mean difference 101 μm; 95% confidence interval (CI) 9/194 μm; P = 0.033). At the brachial artery, migraine patients displayed a smaller distension (difference -24 μm; 95% CI -45/-4 μm; P = 0.021) and a decreased compliance (difference -0.025 mm2/kPa; 95% CI -0.047/-0.003 mm2/kPa; P = 0.024). Thus, migraine patients display an increased peripheral arterial stiffness. The presence of these interictal vascular changes suggests that migraine might be part of a more generalized vascular disorder.
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Fischer-Rasokat, Spyridopoulos, Walter, Honold, M. Zeiher, and Fichtlscherer. "Microvascular dysfunction and pulse wave reflection characterize different vascular pathologies in patients at cardiovascular risk." Vasa 41, no. 3 (May 1, 2012): 192–99. http://dx.doi.org/10.1024/0301-1526/a000185.
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Background: Endothelial function and arterial pulse wave reflections play a crucial role in the pathogenesis of atherosclerosis. While the endothelium-dependent reactive hyperemia index (RHI) of the digital arteries is considered as a marker of microvascular function, an increased augmentation index (AI) may indicate beginning macrovascular damage. In this study we assessed the interrelationships among these noninvasive measures of vascular function. Patients and methods: In 178 all-comer patients with documented cardiovascular risk factors (22 % female; 65 % coronary artery disease, CAD), we measured radial AI (rAI) by radial applanation tonometry and digital AI (dAI) as well as RHI by using fingertip peripheral arterial tonometry. A modified SMART risk score was calculated in all participants based on cardiovascular risk factors and preexisting vascular disease. Results: dAI and rAI demonstrated a significant and robust overall correlation (Pearson rank coefficient r = 0.63, p < 0.01), which was not affected by age, sex, diabetes mellitus and CAD. In contrast, both parameters demonstrated at most a weak correlation (dAI: r = 0.26, p < 0.01 and rAI: r = 0.12, p = 0.10) with microvascular function (RHI). While dAI and rAI were significantly correlated to female sex, age, low body height, low heart rate and the presence of CAD, RHI was associated with the presence of diabetes mellitus and nicotine use. Finally, only microvascular function was associated with the modified SMART risk score, but not augmentation indices. Conclusions: RHI and increased pulse wave reflection appear to represent two distinct vascular pathologies in patients with cardiovascular risk. In contrast, RHI might be useful to identify patients at highest cardiovascular risk once atherosclerotic disease has been diagnosed.
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Munir, Shahzad, Benyu Jiang, Antoine Guilcher, Sally Brett, Simon Redwood, Michael Marber, and Philip Chowienczyk. "Exercise reduces arterial pressure augmentation through vasodilation of muscular arteries in humans." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 4 (April 2008): H1645—H1650. http://dx.doi.org/10.1152/ajpheart.01171.2007.
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Exercise markedly influences pulse wave morphology, but the mechanism is unknown. We investigated whether effects of exercise on the arterial pulse result from alterations in stroke volume or pulse wave velocity (PWV)/large artery stiffness or reduction of pressure wave reflection. Healthy subjects ( n = 25) performed bicycle ergometry. with workload increasing from 25 to 150 W for 12 min. Digital arterial pressure waveforms were recorded using a servo-controlled finger cuff. Radial arterial pressure waveforms and carotid-femoral PWV were determined by applanation tonometry. Stroke volume was measured by echocardiography, and brachial and femoral artery blood flows and diameters were measured by ultrasound. Digital waveforms were recorded continuously. Other measurements were made before and after exercise. Exercise markedly reduced late systolic and diastolic augmentation of the peripheral pressure pulse. At 15 min into recovery, stroke volume and PWV were similar to baseline values, but changes in pulse wave morphology persisted. Late systolic augmentation index (radial pulse) was reduced from 54 ± 3.9% at baseline to 42 ± 3.7% ( P < 0.01), and diastolic augmentation index (radial pulse) was reduced from 37 ± 1.8% to 25 ± 2.9% ( P < 0.001). These changes were accompanied by an increase in femoral blood flow (from 409 ± 44 to 773 ± 48 ml/min, P < 0.05) and an increase in femoral artery diameter (from 8.2 ± 0.4 to 8.6 ± 0.4 mm, P < 0.05). In conclusion, exercise dilates muscular arteries and reduces arterial pressure augmentation, an effect that will enhance ventricular-vascular coupling and reduce load on the left ventricle.
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Kruglikova, A. S., I. D. Strajesko, O. N. Tkacheva, D. U. Akasheva, E. V. Plokhova, V. S. Pykhtina, E. V. Dudinskaya, et al. "INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING." Cardiovascular Therapy and Prevention 13, no. 3 (June 20, 2014): 11–17. http://dx.doi.org/10.15829/1728-8800-2014-3-11-17.
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Aim.To study interrelationship between cardiovascular risk factors and cellular and vascular aging processes. Material and methods. Totally 136 patients were included having no signs of cardiovascular diseases, diabetes 2nd type and receiving no drug therapy, but with one or several risk factors for cardiovascular diseases (smoking, arterial hypertension, obesity, dyslipidemia, fasting hyperglycemia). The telomere length and telomerase activity was measured by polymerase chain reaction. The thickness of intima-media complex (TIMC) and presence of atherosclerotic plaques (ASP) were measured by duplex scanning of right and left carotid arteries. Pulse wave velocity (PWV) was measured by applanation tonometry. Biochemical tests done by standard.Results.PWV significantly correlated with age, body mass index, glycosilated hemoglobin level, fasting glycemia and telomere length. Presence of ASP and increased TIMC significantly correlated with age, body mass index, arterial hypertension, dyslipidemia.Conclusion.Increase of arterial wall stiffness and subclinical atherosclerotic disease have different causes. The level of PWV more linked with carbohydrate metabolism disorder, and TIMC and ASP are linked with lipid disorders.
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SEBASTIÁN, GRAF, ZÓCALO YANINA, PESSANA FRANCO, BIA DANIEL, GAMERO LUCAS, SANCHEZ RAMIRO, and ARMENTANO RICARDO. "IN VIVO EVALUATION OF THE HUMAN CAROTID ARTERY COMPLEX ELASTIC MODULUS." Journal of Mechanics in Medicine and Biology 06, no. 02 (June 2006): 189–208. http://dx.doi.org/10.1142/s0219519406001868.
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The arterial wall dynamics evaluation requires the assessment of its frequency-response. The aim was to apply an original methodology, to evaluate the arterial wall pressure-diameter frequency-response and elastic complex modulus, of human in vivo and in vitro common carotid arteries (CCA). CCA pressure, diameter and wall thickness were recorded. In vitro recordings were performed using pressure microtransducer (Konigsberg) and sonomicrometry, in 14 CCA segments (from donors). The in vivo recordings were obtained non-invasively by tonometry and mode-B echography in 10 normotensive patients, and in 10 hypertensive patients before and after 3 months of treatment with an ACE-inhibitor. A system modeling-identification approach was used to estimate the viscoelastic parameters: elastic, viscous and inertial indexes, and to perform an isofrequency analysis (up to 5Hz) of the incremental elastic modulus E inc (jω) of the arterial wall. The new approach, proposed to evaluate the frequency-dependence of arterial wall mechanics, was applied satisfactorily.
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Petrovic, Nenad, Tatjana Sarenac, Milos Todorovic, Suncica Sreckovic, Mirjana Janicijevic-Petrovic, and Katarina Janicijevic. "Cilioretinal arteries and collateral vessels after occlusion of central retinal artery." Vojnosanitetski pregled 75, no. 7 (2018): 716–20. http://dx.doi.org/10.2298/vsp160510286p.
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Background/Aim. Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the central retinal artery is blocked. It causes sudden, painless, unilateral and usually severe vision loss. The aim of our study was to examine significance of cilioretinal artery on collateral and neovasculatization development after occlusion of the central retinal artery. Methods. This study retrospectively reviewed all fluorescein angiography (FA) cases with confirmed CRAO and presenting, one or more, cilioretinal arteries on initial examination. The study included patients referred to the Clinic of Ophthalmology, Clinical Center Kragujevac for the examination in the period from January 2010 to January 2015. Ten eyes of 10 patients with confirmed CRAO and existing cilioretinal artery on initial examination were found and analyzed in this study. Results. This study included 10 (6 males and 4 females) patients from 50 to 76 years old (mean 66.3 ? 10.078 years). Visual acuity on initial examination presented on the decimal scale was from 0.01 to 0.2 (mean 0.087 ? 0.066). Intraocular pressure measured by applanation tonometry was in the range from 14 to 20 mmHg (mean 16.7 ? 2.540 mmHg). Cilioretinal artery was revealed on the first FA examination of all eyes. On control FA, in three eyes de novo collaterals were discovered. In the first eye, collaterals were discovered after two months, in the second eye after four months, and in the third eye after seven months of the performing the initial angiogram. Visual acuity was checked after one year. It was from light perception to 0.03 (mean 0.016 ? 0.009). Conclusion. The presence of cilioretinal arteries with preexisting or de novo developed collaterals was not enough to preserve visual acuity and prevent neovascularisation over a longer period after CRAO
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Sugawara, Jun, Tsubasa Tomoto, Hsin-Fu Lin, Chen-Huan Chen, and Hirofumi Tanaka. "Aortic reservoir function of Japanese female pearl divers." Journal of Applied Physiology 125, no. 6 (December 1, 2018): 1901–5. http://dx.doi.org/10.1152/japplphysiol.00466.2018.
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Female pearl divers in Japan, called “ Ama,” engage in repeated breath-hold free-diving maneuvers for collecting pearls, seaweeds, and shellfish in the cold sea. We previously reported that they have lower systemic arterial stiffness than age-matched sedentary peers. As a follow-up study, we evaluated their segmental arterial stiffness and aortic reservoir function. A total of 120 non-medicated women living in the same fishing villages (mean age: 65 ± 11 yr), including 88 Ama and 32 age-matched sedentary peers, were studied. Pulse wave velocity from the heart to the brachial artery (hbPWV; partly reflecting proximal aortic stiffness) and between the brachial artery and the ankle (baPWV; reflecting stiffness of abdominal aorta and leg arteries) were measured. Aortic hemodynamic variables were estimated from applanation tonometry carotid arterial pressure waveforms via general transfer function. Carotid artery impedance was calculated from blood flow velocity and blood pressure of contralateral common carotid arteries. baPWV was not different between the groups ( P = 0.117), whereas hbPWV was significantly lower in pearl divers than sedentary peers ( P = 0.004). Additionally, Ama had significantly lower aortic reservoir pressure integral ( P = 0.029) and carotid artery impedance modulus in frequency ranges from 0.78 to 4.0 Hz ( P = 0.011~0.019) than in sedentary peers. Collectively, these findings indicate that lifelong female pearl divers have superior reservoir function in central elastic arteries (e.g., the proximal aorta and carotid artery) in comparison with age-matched sedentary women living in the same fishing village. NEW & NOTEWORTHY We previously reported that lifelong female pearl divers in Japan, called “ Ama,” have lower systemic arterial stiffness than age-matched sedentary peers. As a follow-up study, we evaluated their segmental arterial stiffness and aortic reservoir function. In comparison with age-matched sedentary women living in the same fishing village, Ama demonstrated significantly lower arterial stiffness in more proximal and elastic arterial segments and superior reservoir function in central elastic arteries.
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Umapathy, E., S. T. Muthiraparampil, and A. Namugowa. "Assessment of variations in arterial tone during different phases of menstrual cycle." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 5 (April 29, 2019): 1810. http://dx.doi.org/10.18203/2320-1770.ijrcog20191924.
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Background: Arterial tone parameters in young African women during the different phases of menstrual cycle were assessed in the present study.Methods: Out of the 30 student volunteers who participated in the study, only 15 completed the study. Anthropometric data using stadiometer, blood pressure using automated oscillometric pressure gauge were measured. Arterial stiffness parameters at the radial and ECG gated carotid and femoral arteries using sphygmocor tonometry was mesured in two consecutive menstrual cycles at early follicular, ovulation and luteal phase. Estrogen and progesterone concentrations were analyzed using Elisa kits in all three phases.Results: Estrogen level in ovulation phase and progesterone in luteal phase were higher. Peripheral augmentation index in ovulation phase was higher compared to luteal phase. Pulse pressure amplification value at follicular and luteal phases was higher than in ovulation phase. Pulse wave velocity and pulse pressure amplification was negatively correlated to progesterone in follicular phase. The arterial stiffness increased at ovulation and decreased in follicular and luteal phases of menstrual cycle.Conclusions: No significant correlation between arterial stiffness parameters and ovarian hormones was found.
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Pinter, Alexandra, Andrea Laszlo, Beatrix Mersich, Krisztina Kadar, and Mark Kollai. "Adaptation of baroreflex function to increased carotid artery stiffening in patients with transposition of great arteries." Clinical Science 113, no. 1 (June 1, 2007): 41–46. http://dx.doi.org/10.1042/cs20060363.
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We have shown previously that TGA (transposition of great arteries) is associated with increased carotid artery stiffness. It has been established that stiffening of the barosensory vessel wall results in reduced baroreceptor activation and impaired BRS (baroreflex sensitivity). In the present study we tested the hypothesis that the increased carotid artery stiffness in TGA patients was associated with reduced cardiovagal BRS. We studied 32 TGA patients aged 9–19 years, 12±3 years after surgical repair and 32 age-matched healthy control subjects. Carotid artery diastolic diameter and pulsatile distension was determined by echo wall tracking; carotid blood pressure was measured by tonometry. BRS was measured using spontaneous techniques [BRSseq and LFgain (low-frequency transfer function gain)] and by the phenylephrine method (BRSphe). Carotid artery distensibility was markedly reduced in patients as compared with controls (5.6±1.9×10−3 compared with 8.7±2.7×10−3/mmHg P<0.05, as determined using an unpaired Student's t test), but BRS was not different in patients and controls (20.3±14.7 compared with 21.7±12.7 for BRSseq; 13.1±9.2 compared with 10.6±4.5 for LFgain; and 19.1±8.6 compared with 24.8±7.2 for BRSphe respectively). Carotid artery elastic function was markedly impaired in patients with TGA, but the increased stiffness of the barosensory vessel wall was not associated with reduced BRS. It appears that attenuation of baroreceptor stimulus due to arterial stiffening may be compensated by other, possibly neural, mechanisms when it exists as a congenital abnormality.
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Khromova, A. A., L. I. Salyamova, O. G. Kvasova, and V. E. Oleinikov. "Conventional risk factors and arterial bed parameters in patients with coronary artery disease younger and older than 50 years." Cardiovascular Therapy and Prevention 19, no. 4 (September 5, 2020): 2541. http://dx.doi.org/10.15829/1728-8800-2020-2541.
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Aim. To study conventional risk factors and arterial stiffness parameters to identify non-invasive markers of coronary atherosclerosis in patients with and without history of cardiovascular disease, with premature and physiological vascular aging.Material and methods. The study included 198 patients with coronary artery disease (CAD) and 57 healthy people. The subjects were divided into two cohorts: younger and older than 50 years. Each group included patients with newly diagnosed acute coronary syndrome with/without history of cardiovascular disease (CAD and/or hypertension). Conventional risk factors were analyzed in all subjects. Ultrasound radiofrequency of common carotid arteries (CCA), applanation tonometry, volume sphygmography were performed.Results. Analysis of arterial parameters in individuals <50 years old revealed differences between healthy people and patients with CAD. In the subgroup of patients without a history of cardiovascular disease compared with healthy people, CCA were damaged in 77% (p<0,05), aorta — in 13%, muscular arteries — in 29% (p<0,05); in patients with a history of cardiovascular disease, in 71% (p<0,05), 5% and 34% (p<0,05), respectively. In the older age group of patients with and without history of cardiovascular disease, CCA were damaged in 84% and 94% (p<0,05), aorta — in 92% and 87% (p<0,05), muscular arteries — in 42-44% (p<0,05), respectively. According to the ROC analysis, in patients <50 years old, the area under the curve (AUC) for the intima-media thickness (IMT) was 0,830, the threshold — 622,3 (p=0,000); for the beta stiffness index — 0,850, threshold — 7,01 (p=0,002); for L-/CAVI1 — 0,742, threshold — 7,3 (p=0,000). In patients >50 years of age, AUC for the IMT was 0,948, threshold — 607,5 (p=0,000); for the beta stiffness index — 0,740, threshold — 8,84 (p=0,000); for L-/CAVI1 — 0,861, threshold — 8,4 (p=0,000).Conclusion. Timely identification of atherosclerotic markers using noninvasive techniques can improve the prediction of cardiovascular events. A comprehensive non-invasive examination of the arteries with determination of IMT, beta stiffness index, and L-/CAVI1 will probably identify young people with an unfavorable absolute cardiovascular risk. .
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Reymond, Philippe, Fabrice Merenda, Fabienne Perren, Daniel Rüfenacht, and Nikos Stergiopulos. "Validation of a one-dimensional model of the systemic arterial tree." American Journal of Physiology-Heart and Circulatory Physiology 297, no. 1 (July 2009): H208—H222. http://dx.doi.org/10.1152/ajpheart.00037.2009.
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A distributed model of the human arterial tree including all main systemic arteries coupled to a heart model is developed. The one-dimensional (1-D) form of the momentum and continuity equations is solved numerically to obtain pressures and flows throughout the systemic arterial tree. Intimal shear is modeled using the Witzig-Womersley theory. A nonlinear viscoelastic constitutive law for the arterial wall is considered. The left ventricle is modeled using the varying elastance model. Distal vessels are terminated with three-element windkessels. Coronaries are modeled assuming a systolic flow impediment proportional to ventricular varying elastance. Arterial dimensions were taken from previous 1-D models and were extended to include a detailed description of cerebral vasculature. Elastic properties were taken from the literature. To validate model predictions, noninvasive measurements of pressure and flow were performed in young volunteers. Flow in large arteries was measured with MRI, cerebral flow with ultrasound Doppler, and pressure with tonometry. The resulting 1-D model is the most complete, because it encompasses all major segments of the arterial tree, accounts for ventricular-vascular interaction, and includes an improved description of shear stress and wall viscoelasticity. Model predictions at different arterial locations compared well with measured flow and pressure waves at the same anatomical points, reflecting the agreement in the general characteristics of the “generic 1-D model” and the “average subject” of our volunteer population. The study constitutes a first validation of the complete 1-D model using human pressure and flow data and supports the applicability of the 1-D model in the human circulation.
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Zócalo, Yanina, Rodolfo Ungerfeld, Raquel Pérez-Clariget, and Daniel Bia. "Maternal nutritional restriction during gestation impacts differently on offspring muscular and elastic arteries and is associated with increased carotid resistance and ventricular afterload in maturity." Journal of Developmental Origins of Health and Disease 11, no. 1 (May 29, 2019): 7–17. http://dx.doi.org/10.1017/s2040174419000230.
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AbstractBackground:Intrauterine undernutrition could impact offspring left ventricle (LV) afterload and arterial function. The changes observed in adulthood could differ depending on the arterial type, pathway and properties studied. Aim: To analyze whether undernutrition during early and mid-gestation is associated with changes in cardiovascular properties in adulthood.Methods:Pregnant ewes were assigned to one of the two treatment groups: (1) standard nutritional offer (high pasture-allowance, HPA; n = 16) or (2) nutritional restriction (50–75% of control intake) from before conception until day 122 of gestation (≈85% term) (low pasture allowance, LPA; n = 17). When offspring reached adult life, cardiovascular parameters were assessed in conscious animals (applanation tonometry, vascular echography).Measurements:Peripheral and aortic pressure, carotid and femoral arteries diameters, intima-media thickness and stiffness, blood flow, local and regional resistances and LV afterload were measured. Blood samples were collected. Parameters were compared before and after adjustment for nutritional characteristics at birth and at the time of the cardiovascular evaluation.Results:Doppler-derived cerebral vascular resistances, mean pressure/flow ratio (carotid resistance) and afterload indexes were higher in descendants from LPA than in descendants from HPA ewes (p < 0.05). Descendants from LPA had lower femoral diameters (p < 0.05). Cardiovascular changes associated with nutritional restriction during pregnancy did not depend on the offsprings’ nutritional conditions at birth and/or in adult life.Conclusion:Pregnant ewes that experienced undernutrition gave birth to female offspring that exhibited increased carotid pathway resistances (cerebral microcirculatory resistances) and LV afterload when they reached the age of 2.5 years. There were differences in the impact of nutritional deficiency on elastic and muscular arteries.
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Wiegerinck, A. I. P., A. Thomsen, J. Hisdal, H. Kalvøy, and C. Tronstad. "Electrical impedance plethysmography versus tonometry to measure the pulse wave velocity in peripheral arteries in young healthy volunteers: a pilot study." Journal of Electrical Bioimpedance 12, no. 1 (January 1, 2021): 169–77. http://dx.doi.org/10.2478/joeb-2021-0020.
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Abstract The leading cause of health loss and deaths worldwide are cardiovascular diseases. A predictor of cardiovascular diseases and events is the arterial stiffness. The pulse wave velocity (PWV) can be used to estimate arterial stiffness non-invasively. The tonometer is considered as the gold standard for measuring PWV. This approach requires manual probe fixation above the artery and depends on the skills of the operator. Electrical impedance plethysmography (IPG) is an interesting alternative using skin surface sensing electrodes, that is miniaturizable, cost-effective and allows measurement of deeper arteries. The aim of this pilot study was to explore if IPG can be a suitable technique to measure pulse wave velocity in legs as an alternative for the tonometer technique. The PWV was estimated by differences in the ECG-gated pulse arrival times (PAT) at the a. femoralis, a. popliteal, a. tibialis dorsalis and a. dorsalis pedis in nine healthy young adults using IPG and the SphygmoCor tonometer as a reference. The estimated PWV results from bioimpedance and the tonometer were fairly in agreement, and the beat-to-beat variability in PAT was similar. This pilot study indicates that the use of IPG may be a good alternative for estimating PWV in the legs.
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Åström Malm, Ida, Rachel De Basso, Peter Blomstrand, and Dick Wågsäter. "Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm." Journal of Clinical Medicine 11, no. 5 (February 23, 2022): 1182. http://dx.doi.org/10.3390/jcm11051182.
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Background: Markers of inflammation and arterial stiffness are predictors of cardiovascular morbidity and events, but their roles in the mechanisms and progression of abdominal aortic aneurysm (AAA) in males have not been fully investigated. This study explored possible associations between inflammatory marker levels and arterial stiffness in males with AAA. Methods: A total of 270 males (191 AAA and 79 controls) were included in the study. Arterial stiffness was assessed using non-invasive applanation tonometry to measure the regional pulse wave velocity between the carotid and femoral arteries and the carotid and radial arteries. Blood samples were obtained, and interleukin-10 (IL-10) and CRP levels were analysed. Results: Subjects with an AAA had higher levels of IL-10 (21.5 ± 14.0 ng/mL versus 16.6 ± 9.3 ng/mL) compared to controls (p = 0.007). In the AAA cohort, subjects with T2DM showed higher levels of IL-10 (26.4 ± 17.3 versus 20.4 ± 13.0, p = 0.036). We observed a positive correlation between PWVcf and CRP in the control group (r = 0.332) but not the AAA group. PWVcf and CRP were negatively correlated (r = 0.571) in the T2DM subjects treated with metformin in the AAA group. Conclusion: Arterial stiffness is related to the degree of inflammation reflected by CRP and IL-10 levels in males with an AAA. IL-10 is negatively correlated with arterial stiffness in these subjects. This finding suggests that IL-10 may decrease arterial stiffness in males with AAA. The negative correlation between CRP and PWVcf in males with T2DM treated with metformin may indicate that metformin influences the arterial wall to decrease stiffness in subjects with AAA.
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Rizzoni, Damiano, Alessandro Mengozzi, Stefano Masi, Claudia Agabiti Rosei, Carolina De Ciuceis, and Agostino Virdis. "New Noninvasive Methods to Evaluate Microvascular Structure and Function." Hypertension 79, no. 5 (May 2022): 874–86. http://dx.doi.org/10.1161/hypertensionaha.121.17954.
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The structural and functional alterations of microvessels are detected because of physiological aging and in several cardiometabolic diseases, including hypertension, diabetes, and obesity. The small resistance arteries of these patients show an increase in the media or total wall thickness to internal lumen diameter ratio (MLR or WLR), often accompanied by endothelial dysfunction. For decades, micromyography has been considered as a gold standard method for evaluating microvascular structural alterations through the measurement of MLR or WLR of subcutaneous small vessels dissected from tissue biopsies. Micromyography is the most common and reliable method for assessing microcirculatory endothelial function ex vivo, while strain-gauge venous plethysmography is considered the reference technique for in vivo studies. Recently, several noninvasive methods have been proposed to extend the microvasculature evaluation to a broader range of patients and clinical settings. Scanning laser Doppler flowmetry and adaptive optics are increasingly used to estimate the WLR of retinal arterioles. Microvascular endothelial function may be evaluated in the retina by flicker light stimulus, in the finger by tonometric approaches, or in the cutaneous or sublingual tissues by laser Doppler flowmetry or intravital microscopy. The main limitation of these techniques is the lack of robust evidence on their prognostic value, which currently reduces their widespread use in daily clinical practice. Ongoing and future studies will overcome this issue, hopefully moving the noninvasive assessment of the microvascular function and structure from bench to bedside.
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Montone, Rocco A., Giampaolo Niccoli, Federico Vergni, Vincenzo Vetrugno, Michele Russo, Fabio Mangiacapra, Francesco Fracassi, et al. "Endothelial dysfunction as predictor of angina recurrence after successful percutaneous coronary intervention using second generation drug eluting stents." European Journal of Preventive Cardiology 25, no. 13 (May 22, 2018): 1360–70. http://dx.doi.org/10.1177/2047487318777435.
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Background The role of endothelial dysfunction in predicting angina recurrence after percutaneous coronary intervention is unknown. Design We assessed the role of peripheral endothelial dysfunction measured by reactive-hyperaemia peripheral-artery tonometry (RH-PAT) in predicting recurrence of angina after percutaneous coronary intervention. Methods We enrolled consecutive patients undergoing percutaneous coronary intervention with second-generation drug-eluting stents. RH-PAT was measured at discharge. The endpoint was repeated coronary angiography for angina recurrence and/or evidence of myocardial ischaemia at follow-up. Patients with in-stent restenosis and/or significant de novo stenosis were defined as having angina with obstructed coronary arteries (AOCA); all other patients as having angina with non-obstructed coronary arteries (ANOCA). Results Among 100 patients (mean age 66.7 ± 10.4 years, 80 (80.0%) male, median follow-up 16 (3–20) months), AOCA occurred in 14 patients (14%), ANOCA in nine patients (9%). Repeated coronary angiography occurred more frequently among patients in the lower RH-PAT index tertile compared with middle and upper tertiles (14 (41.2%) vs. 6 (18.2%) vs. 3 (9.1%), p = 0.006, respectively). ANOCA was more frequent in the lower RH-PAT index tertile compared with middle and upper tertiles. In the multivariate regression analysis, the RH-PAT index only predicted angina recurrence. The receiver operating characteristic curve of the RH-PAT index to predict the angina recurrence demonstrated an area under the curve of 0.79 (95% confidence interval: 0.69–0.89; p < 0.001), with a cut-off value of 1.705, having sensitivity 74% and specificity 70%. Conclusions Non-invasive assessment of peripheral endothelial dysfunction using RH-PAT might help in the prediction of recurrent angina after percutaneous coronary intervention, thus identifying patients who may need more intense pharmacological treatment and risk factor control.
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Giroux, Julie, Maureen Alivon, Marie Briet, Pascaline Boudou-Rouquette, Stanislas Ropert, Anatole Cessot, Jean-Philippe Durand, Pierre Boutouyrie, Stephane Laurent, and Francois Goldwasser. "Arterial stiffness to predict hypertensive response to antiangiogenic drugs." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e13589-e13589. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e13589.
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e13589 Background: Targeting angiogenesis with anti-VEGF receptors is a new approach for cancer treatment. The most common side effect is arterial hypertension. We hypothesize that pre-existing large artery remodeling with increased arterial stiffness is a determinant of blood pressure (BP) increase under antiangiogenic (AAD) and that AAD may alter mechanical properties of large arteries independently of BP increase. Methods: 49 patients (mean age=57[15] years, mean bSBP=128[22] mmHg and mean DBP=75[11] mmHg; treated for a cancer with an indication to start AAD (Sorafenib, Sunitinib or Bevacizumab) were included in this longitudinal study. Arterial evaluation was assessed at baseline (BL) before the introduction of AAD and every two weeks for 2 months (V1 to V4) with aortic stiffness (PWV) and central BP measurements by aplanation tonometry (SphygmoCor), carotid distensibility with high resolution echotracking system (ArtLab). Results: 43% of the patients developed hypertension between BL and V1. Using linear mixed model analysis with random effects, PWV significantly increased between BL and V1 (BL-V1, adjusted slope 0.89 m/s, F value=6.8, p=0.04) after adjustment to age and mean BP, carotid distensibility decreased significantly during follow-up (BL-V1, adjusted slope= -4.4, p=0.04; BL-V2, adjusted slope= -5.23, p=0.001) after adjustment to age and mean BP. The determinants of BP increase were studied between BL and V1 since anti-hypertensive drugs were introduced after V1. Using multivariate analysis, BL PWV was an independent determinant of the delta brachial SBP (β= -1.36 [-2.61; 0.11], p=0.034) with age (β=0.25 [0.04; 0.47], p=0.02). Conclusions: AAD induce functional alterations of large arteries, increasing arterial stiffness, independently of BP increase. In addition, pre-AAD administration arterial properties influence the hypertensive response to AAD.
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Salvi, Paolo, Filippo Valbusa, Anna Kearney-Schwartz, Carlos Labat, Andrea Grillo, Gianfranco Parati, and Athanase Benetos. "Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods." Journal of Clinical Medicine 11, no. 8 (April 15, 2022): 2225. http://dx.doi.org/10.3390/jcm11082225.
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Background: The stiffening of large elastic arteries is currently estimated in research and clinical practice by propagative and non-propagative models, as well as parameters derived from aortic pulse waveform analysis. Methods: Common carotid compliance and distensibility were measured by simultaneously recording the diameter and pressure changes during the cardiac cycle. The aortic and upper arm arterial distensibility was estimated by measuring carotid–femoral and carotid–radial pulse wave velocity (PWV), respectively. The augmentation index and blood pressure amplification were derived from the analysis of central pulse waveforms, recorded by applanation tonometry directly from the common carotid artery. Results: 75 volunteers were enrolled in this study (50 females, average age 53.5 years). A significant inverse correlation was found between carotid distensibility and carotid–femoral PWV (r = −0.75; p < 0.001), augmentation index (r = −0.63; p < 0.001) and central pulse pressure (r = −0.59; p < 0.001). A strong correlation was found also between the total slope of the diameter/pressure rate carotid curves and aortic distensibility, quantified from the inverse of the square of carotid–femoral PWV (r = 0.67). No correlation was found between carotid distensibility and carotid–radial PWV. Conclusions: This study showed a close correlation between carotid–femoral PWV, evaluating aortic stiffness by using the propagative method, and local carotid cross-sectional distensibility.
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Tarumi, Takashi, Muhammad Ayaz Khan, Jie Liu, Benjamin M. Tseng, Rosemary Parker, Jonathan Riley, Cynthia Tinajero, and Rong Zhang. "Cerebral Hemodynamics in Normal Aging: Central Artery Stiffness, Wave Reflection, and Pressure Pulsatility." Journal of Cerebral Blood Flow & Metabolism 34, no. 6 (March 19, 2014): 971–78. http://dx.doi.org/10.1038/jcbfm.2014.44.
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Blood ejected from the left ventricle perfuses the brain via central elastic arteries, which stiffen with advancing age and may elevate the risk of end-organ damage. The purpose of this study was to determine the impact of central arterial aging on cerebral hemodynamics. Eighty-three healthy participants aged 22 to 80 years underwent the measurements of cerebral blood flow (CBF) and CBF velocity (CBFV) using magnetic resonance imaging (MRI) and transcranial Doppler, respectively. The CBF pulsatility was determined by the relative amplitude of CBFV to the mean value (CBFV%). Central arterial stiffness (carotid-femoral pulse wave velocity), wave reflection (carotid augmentation index), and pressure were measured using applanation tonometry. Total volume of white-matter hyperintensity (WMH) was quantified from MR images. Total CBF decreased with age while systolic and pulsatile CBFV% increased and diastolic CBFV% decreased. Women showed greater total CBF and lower cerebrovascular resistance than men. Diastolic CBFV% was lower in women than in men. Age- and sex-related differences in CBF pulsatility were independently associated with carotid pulse pressure and arterial wave reflection. In older participants, higher pulsatility of CBF was associated with the greater total volume of WMH. These findings indicate that central arterial aging has an important role in age-related differences in cerebral hemodynamics.
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Dadoniene, Jolanta, Alma Cypiene, Ligita Ryliskyte, Rita Rugiene, Kristina Ryliškiene, and Aleksandras Laucevičius. "Skin Autofluorescence in Systemic Sclerosis Is Related to the Disease and Vascular Damage: A Cross-Sectional Analytic Study of Comparative Groups." Disease Markers 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/837470.
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Skin autofluorescence (AF), a relatively simple and time saving procedure, measures the accumulation of advanced glycation end (AGE) products. The importance in autoimmune rheumatic diseases, particularly, systemic sclerosis (SSc), has not been evaluated yet. The aim of our study was to examine the skin AF in the context of SSc patients and to analyse the relations between skin AF and other surrogate measures of atherosclerosis. Forty-seven patients with SSc and 47 healthy volunteers were included in this study as controls. Patients and controls underwent common carotid artery wall assessment, arterial stiffness and wave reflection measurements, laser Doppler measurements of capillary flow, assessment of endothelial function by brachial ultrasound, peripheral arterial tonometry, and AGE measurement by skin AF. Wall properties of the common carotid arteries and wave reflection measurements were not affected in these study patients compared to controls while measures reflecting small capillary flow were altered. The accumulation of AGE products measured by skin AF was more prominent in SSc patients than in healthy controls. AGE products’ score was significantly associated with carotid radial pulse wave velocity, intima media/carotid artery diameter ratio, capillary flow percentage change during occlusion, and the disease itself in a multivariate linear analysis model.
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Inkeri, Jussi, Anniina Tynjälä, Carol Forsblom, Ron Liebkind, Turgut Tatlisumak, Lena M. Thorn, Per-Henrik Groop, et al. "Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes." Acta Diabetologica 58, no. 7 (March 20, 2021): 929–37. http://dx.doi.org/10.1007/s00592-021-01678-x.
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Abstract Aims To determine if arterial functional and structural changes are associated with underlying cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes. Methods We enrolled 186 individuals (47.8% men; median age 40.0, IQR 33.0—45.0 years) with type 1 diabetes (median diabetes duration of 21.6, IQR 18.2—30.3 years), and 30 age- and sex-matched healthy controls, as part of the Finnish Diabetic Nephropathy (FinnDiane) Study. All individuals underwent a biochemical work-up, brain magnetic resonance imaging (MRI), ultrasound of the common carotid arteries and arterial tonometry. Arterial structural and functional parameters were assessed by carotid intima-media thickness (CIMT), pulse wave velocity and augmentation index. Results Cerebral microbleeds (CMBs) were present in 23.7% and white matter hyperintensities (WMHs) in 16.7% of individuals with type 1 diabetes. Those with type 1 diabetes and CMBs had higher median (IQR) CIMT 583 (525 – 663) μm than those without 556 (502 – 607) μm, p = 0.016). Higher CIMT was associated with the presence of CMBs (p = 0.046) independent of age, eGFR, ApoB, systolic blood pressure, albuminuria, history of retinal photocoagulation and HbA1c. Arterial stiffness and CIMT were increased in individuals with type 1 diabetes and WMHs compared to those without; however, these results were not independent of cardiovascular risk factors. Conclusions Structural, but not functional, arterial changes are associated with underlying CMBs in asymptomatic individuals with type 1 diabetes.
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Reymond, Philippe, Yvette Bohraus, Fabienne Perren, Francois Lazeyras, and Nikos Stergiopulos. "Validation of a patient-specific one-dimensional model of the systemic arterial tree." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 3 (September 2011): H1173—H1182. http://dx.doi.org/10.1152/ajpheart.00821.2010.
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The aim of this study is to develop and validate a patient-specific distributed model of the systemic arterial tree. This model is built using geometric and hemodynamic data measured on a specific person and validated with noninvasive measurements of flow and pressure on the same person, providing thus a patient-specific model and validation. The systemic arterial tree geometry was obtained from MR angiographic measurements. A nonlinear viscoelastic constitutive law for the arterial wall is considered. Arterial wall distensibility is based on literature data and adapted to match the wave propagation velocity of the main arteries of the specific subject, which were estimated by pressure waves traveling time. The intimal shear stress is modeled using the Witzig-Womersley theory. Blood pressure is measured using applanation tonometry and flow rate using transcranial ultrasound and phase-contrast-MRI. The model predicts pressure and flow waveforms in good qualitative and quantitative agreement with the in vivo measurements, in terms of wave shape and specific wave features. Comparison with a generic one-dimensional model shows that the patient-specific model better predicts pressure and flow at specific arterial sites. These results obtained let us conclude that a patient-specific one-dimensional model of the arterial tree is able to predict well pressure and flow waveforms in the main systemic circulation, whereas this is not always the case for a generic one-dimensional model.
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Cook, Jill N., Allison E. DeVan, Jessica L. Schleifer, Maria M. Anton, Miriam Y. Cortez-Cooper, and Hirofumi Tanaka. "Arterial compliance of rowers: implications for combined aerobic and strength training on arterial elasticity." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 4 (April 2006): H1596—H1600. http://dx.doi.org/10.1152/ajpheart.01054.2005.
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Regular endurance exercise increases central arterial compliance, whereas resistance training decreases it. It is not known how the vasculature adapts to a combination of endurance and resistance training. Rowing is unique, because its training encompasses endurance- and strength-training components. We used a cross-sectional study design to determine arterial compliance of 15 healthy, habitual rowers [50 ± 9 (SD) yr, 11 men and 4 women] and 15 sedentary controls (52 ± 8 yr, 10 men and 5 women). Rowers had been training 5.4 ± 1.2 days/wk for 5.7 ± 4.0 yr. The two groups were matched for age, body composition, blood pressure, and metabolic risk factors. Central arterial compliance (simultaneous ultrasound and applanation tonometry on the common carotid artery) was higher ( P < 0.001) and carotid β-stiffness index was lower ( P < 0.001) in rowers than in sedentary controls. There were no group differences for measures of peripheral (femoral) arterial stiffness. The higher central arterial compliance in rowers was associated with a greater cardiovagal baroreflex sensitivity, as estimated during a Valsalva maneuver ( r = 0.54, P < 0.005). In conclusion, regular rowing exercise in middle-aged and older adults is associated with a favorable effect on the elastic properties of the central arteries. Our results suggest that simultaneously performed endurance training may negate the stiffening effects of strength training.
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DeVan, Allison E., Maria M. Anton, Jill N. Cook, Daria B. Neidre, Miriam Y. Cortez-Cooper, and Hirofumi Tanaka. "Acute effects of resistance exercise on arterial compliance." Journal of Applied Physiology 98, no. 6 (June 2005): 2287–91. http://dx.doi.org/10.1152/japplphysiol.00002.2005.
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Decreased central arterial compliance is an emerging risk factor for cardiovascular disease. Resistance training is associated with reductions in the elastic properties of central arteries. Currently, it is not known whether this reduction is from one bout of resistance exercise or from an adaptation to multiple bouts of resistance training. Sixteen healthy sedentary or recreationally active adults (11 men and 5 women, age 27 ± 1 yr) were studied under parallel experimental conditions on 2 separate days. The order of experiments was randomized between resistance exercise (9 resistance exercises at 75% of 1 repetition maximum) and sham control (seated rest in the exercise room). Baseline hemodynamic values were not different between the two experimental conditions. Carotid arterial compliance (via simultaneous B-mode ultrasound and applanation tonometry) decreased and β-stiffness index increased ( P < 0.01) immediately and 30 min after resistance exercise. Immediately after resistance exercise, carotid systolic blood pressure increased ( P < 0.01), although no changes were observed in brachial systolic blood pressure at any time points. These measures returned to baseline values within 60 min after the completion of resistance exercise. No significant changes in these variables were observed during the sham control condition. These results indicate that one bout of resistance exercise acutely decreases central arterial compliance, but this effect is sustained for <60 min after the completion of resistance exercise.
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Covic, Adrian, David J. A. Goldsmith, Laura Florea, Paul Gusbeth–Tatomir, and Maria Covic. "The Influence of Dialytic Modality on Arterial Stiffness, Pulse Wave Reflections, and Vasomotor Function." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 24, no. 4 (July 2004): 365–72. http://dx.doi.org/10.1177/089686080402400412.
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Background Measurements of aortic stiffness [aortic pulse wave velocity (PWV) and augmentation index (AIx)] have been established as powerful predictors of survival on hemodialysis (HD). Abnormal endothelial-dependent and endothelial-independent vascular reactivity and increased arterial stiffness are commonly described in HD patients. There is, however, a lack of information on the comparative impact of different renal replacement therapies (RRTs) on PWV and AIx, and how these different methods might influence endothelial-dependent abnormal vasodilatation. Objective To describe in a cross-sectional design arterial compliance and distensibility in continuous ambulatory peritoneal dialysis (CAPD) versus HD versus renal transplant (RTx) patients, compared with age- and blood pressure-matched essential hypertensive controls. The PWV and aortic AIx were determined from contour analysis of arterial waveforms recorded by applanation tonometry in 40 CAPD, 41 HD, 20 RTx patients (with normal serum creatinine), and 20 controls with essential hypertension (all normotensive under treatment). Endothelial-dependent and endothelial-independent vascular reactivities were assessed by changes in AIx following challenges with inhaled salbutamol and sublingual nitroglycerin respectively. Results CAPD patients had significantly stiffer arteries than all other categories. The PWV was 8.29 ± 1.09 m/second in CAPD patients, significantly higher ( p < 0.05) compared to HD subjects (7.19 ± 1.87 m/s). Both dialysis subgroups had significantly higher PWV values compared to RTx patients (6.59 ± 1.62 m/s) and essential hypertensive controls (6.34 ± 1.32 m/s), p < 0.05. The AIx had a profile similar to PWV in different RRTs. All groups with the exception of CAPD subjects had a significant decrease in AIx following salbutamol. Moreover, the vasodilatation induced by either nitroglycerin or salbutamol was significantly blunted compared to HD. Overall, both dialysis categories had more abnormal responses compared to RTx patients and essential hypertensive controls. Conclusion CAPD is associated with stiffer arteries and more profoundly abnormal endothelial-dependent vasomotor function, compared to matched HD subjects. These differences in arterial physical properties might explain differences seen in cardiac structure and function between the RRTs.
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Leonova, I. A., O. V. Zakharova, and S. A. Boldueva. "Disorders of endothelium-dependent vasodilation in patients with microvascular angina." Russian Medical Inquiry 6, no. 8 (2022): 427–32. http://dx.doi.org/10.32364/2587-6821-2022-6-8-427-432.
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Background: disorders of both endothelium-dependent and endothelium-independent vasodilation play a role in the pathogenesis of microvascular angina (MVA), the contribution of which may be different. Aim: to study the processes of endothelium-dependent vasodilation (EDV) in patients with primary MVA. Patients and Methods: an open prospective study included 60 patients (mean age 57.3±6.4 years) with MVA, confirmed clinical picture (chest pain), coronary angiography data (the absence of coronary artery stenosis), positive stress test (pain syndrome and/or ST segment depression by ≥2 mm by treadmill exercise stress test), positron emission tomography (PET) myocardial perfusion imaging (MPI) with tests (cold pressor test and with adenosine). Patients with diseases that can lead to secondary microvascular dysfunction were not included in the study. To evaluate the processes of EDV, all patients underwent the following evaluations: peripheral arterial tonometry (PAT), assessment of circulating endothelial cells (CEC), high-sensitivity C-reactive protein (hsCRP), endothelin-1 (ET-1), total antioxidant status. Adding that, the results of a cold pressor test during PET were analyzed. Results: the majority of the examined patients were women — 81.7%. Most of the female patients included in the study (93.9%) were postmenopausal. In all patients with MVA, according to the data of PET MPI with cold pressor test, signs of EDV disorder were detected as a decrease in coronary blood flow through the three coronary arteries. During PET, the index of reactive hyperemia was reduced (<1,67) in all examined patients and amounted to 1.43±0.15. According to the results of laboratory studies, there was an increase in the level of ET-1 and CEC — 3,335 [1,545; 3,952] fmol/L and 14±8 cells/3×105 leukocytes, respectively. The CRP level was 4,44 [1.02; 4.45] mg/L. The total antioxidant capacity was reduced in 53 (88%) patients, the average values of the indicator were 289,03±52,14 μmol/L. Conclusion: according to laboratory and instrumental studies, signs of endothelial dysfunction, namely disorders of EDV, were revealed in all examined patients with primary MVA. KEYWORDS: microvascular angina, peripheral arterial tonometry, endothelium-dependent vasodilation, positron emission tomography. FOR CITATION: Leonova I.A., Zakharova O.V., Boldueva S.A. Disorders of endothelium-dependent vasodilation in patients with microvascular angina. Russian Medical Inquiry. 2022;6(8):427–432 (in Russ.). DOI: 10.32364/2587-6821-2022-6-8-427-432.
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Isaykina, O. Yu, V. B. Rozanov, A. A. Aleksandrov, I. V. Leontyeva, M. B. Kotova, and E. I. Ivanova. "Association of Family History of Cardiovascular Diseases in Boys Aged 12-13 Years with Structural and Functional Indicators of the Left Ventricle and Arterial Stiffness in the Age of 43-46 Years (Results of 32-Year Prospective Follow-up)." Rational Pharmacotherapy in Cardiology 15, no. 6 (January 3, 2020): 854–63. http://dx.doi.org/10.20996/1819-6446-2019-15-6-854-863.
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Aim. To evaluate the association of Family History (FH) of cardiovascular diseases (CVD) in boys aged 12-13 years with the development of structural and functional changes in the left ventricle and stiffness of the main arteries in adulthood (43-46 years old) according to prospective study.Material and methods. For the initial examination, boys were selected whose parents suffered from CVD at a young age or died prematurely from them (risk group). The comparison group was formed from a population sample of boys of a similar age without FH of CVD. The examination included a survey on a standard questionnaire, measurement of anthropometric indicators, blood pressure (BP), pulse counting, determination of the blood lipid spectrum. The intima-media complex thickness (IMT) of the common carotid arteries was measured; echocardiography and applanation tonometry were performed.Results. The group with FH of CVD significantly (p<0.05) differed in childhood in terms of the body mass index (BMI) (18.8 vs 17.6 kg/m2), systolic BP (SBP) (117 vs 107 mm Hg), diastolic BP (DBP) (67 vs 56 mm Hg), average BP (81.8 vs 72.7 mm Hg) and triglycerides (0.79 vs 0.58 mmol/L). In adulthood, increased total cholesterol (TC) level (6.3 vs 5.8 mmol/L; p=0.036) and other indicators of atherogenesis were revealed in the risk group. The risk of fatal outcomes from CVD in the next 10 years in men with a family history of CVD in childhood was significantly higher compared to the control group (1.94 vs. 1.28; p <0.001). The main contribution to the total risk of fatal CVD in middle-aged men was made by TC and smoking. In the group with FH of CVD, higher stiffness of the arteries in adulthood was observed. There were found significant (p=0.002) intergroup differences in the IMT (0.73 vs 0.63 mm). A statistically significant positive relationship between BMI and some structural and functional indicators of the left ventricle and stiffness indicators of the main arteries was revealed. DBP and mean BP in childhood are associated with arterial stiffness in adulthood according to the parameters of central SBP and central DBP. BMI in boys is the most significant predictor for most structural and functional indicators of LV myocardial hypertrophy, in particular, LV myocardial mass (private R2=0.140) and interventricular septum thickness (R2=0.164; p=0.001), and arterial stiffness by central DBP parameter (R2=0.043; p=0.024) in adulthood. The risk of increased IMT development in males in adulthood with FH of CVD is 6.1 times higher than that of their peers without FH.Conclusion. FH of CVD revealed in childhood in males is a risk factor for the development of early atherosclerosis and, due to its ease of detection, can be used as one of the criteria for the formation of high-risk groups for the purpose of primary prevention.
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Tomoto, Tsubasa, Jun Sugawara, Takashi Tarumi, Collin Chiles, Bryon Curtis, Evan P. Pasha, C. Munro Cullum, and Rong Zhang. "Carotid Arterial Stiffness and Cerebral Blood Flow in Amnestic Mild Cognitive Impairment." Current Alzheimer Research 17, no. 12 (February 22, 2021): 1115–25. http://dx.doi.org/10.2174/1567205018666210113155646.
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Background: Central arterial stiffness is an emerging risk factor of age-related cognitive impairment and Alzheimer’s disease (AD). However, the underlying pathophysiological mechanisms remain unclear. Objective: We tested the hypothesis that carotid arterial stiffness is associated with reduced cerebral blood flow (CBF) and increased cerebrovascular resistance (CVR) in patients with amnestic mild cognitive impairment (MCI), a prodromal stage of AD. Methods: Fifty-four patients with amnestic MCI and 24 cognitively normal subjects (CN) of similar age and sex to MCI patients underwent measurements of CBF and carotid β-stiffness index using ultrasonography and applanation tonometry. Total CBF was measured as the sum of CBF from both the internal carotid and vertebral arteries, and divided by total brain tissue mass (assessed with MRI) to obtain normalized CBF (nCBF). Results: Relative to CN subjects, MCI patients showed lower nCBF (53.3 ± 3.2 vs 50.4±3.4 mL/100 g/min, P < 0.001) and higher CVR (0.143 ± 0.019 vs 0.156 ± 0.023 mmHg/mL/min, P < 0.015). Multiple linear regression analysis showed that nCBF was negatively associated with carotid β-stiffness index (B = -0.822, P < 0.001); CVR was positively associated with carotid systolic pressure (B = 0.001, P < 0.001) after adjustment for age, sex, body mass index, and MCI status. Conclusion: These findings suggest that carotid artery stiffening may contribute at least in part to the reduced nCBF and increased CVR in patients with MCI associated with augmented carotid arterial pulsatility.
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Zagidullin, N. Sh, R. Kh Zulkarneev, E. S. Scherbakova, Yu F. Safina, and Sh Z. Zagidullin. "Arterial stiffness as a cardiovascular events risk marker and possibilities for its downregulation by contemporary antihypertensive medications." Kazan medical journal 95, no. 4 (August 15, 2014): 575–81. http://dx.doi.org/10.17816/kmj1847.
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Arterial blood pressure measured by Korotkov’s method is a non-valid predictor for possible cardiovascular events, which requires introduction of new methods of arterial hypertension diagnostics. Recently, the effect on arterial stiffness has become a very important characteristic of antihypertensive drugs overall efficacy. Evaluation of arterial stiffness (central aortic pressure, augmentation index and pulse wave velocity) contributes to more precise cardiovascular risk stratification and reflects target organ damage and the effectiveness of antihypertensive treatment. In particular, pulse wave velocity exceeding 12 m/s is a significant risk factor of cardiovascular events. Arterial compliance can be determined by applanation tonometry, pulse wave shift at the carotid and femoral arteries, finger photoplethysmography, volume pulsoxymetry, echo-tracking, suprasystolic pulse waves recording method and cardio-ankle vascular index. Different effects of antihypertensive drugs on arterial stiffness at the same blood pressure reduction have been repeatedly shown. The article discusses the impact of the most commonly used antihypertensive drugs, including contemporary antihypertensive drugs combinations, on arterial stiffness. Effect of beta-blockers greatly varies depending on the characteristics of the drug, diuretics have neutral effect, calcium antagonists (especially amlodipine) decrease the pulse wave speed and arterial wall stiffness. Both angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers (more data for enalapril, perindopril and valsartan) were effective in decreasing arterial wall stiffness. A significant reduction in arterial wall stiffness was mainly found if antihypertensive drugs combinations were used, especially the combination of calcium antagonists and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers.
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Luksch, Alexandra, Barbara Wimpissinger, Kaija Polak, Kerstin Jandrasits, and Leopold Schmetterer. "ETa-receptor blockade, but not ACE inhibition, blunts retinal vessel response during isometric exercise." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 4 (April 2006): H1693—H1698. http://dx.doi.org/10.1152/ajpheart.00947.2005.
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Angiotensin II and endothelin-1 are potent vasoconstrictors that appear to play a role in retinal blood flow regulation. In the present study, we investigated the possible role of the angiotensin and the endothelin system in the regulation of retinal vessel diameters during isometric exercise in healthy humans. The study design was randomized, double-masked, placebo-controlled, and three-way cross over. Twelve healthy subjects performed squatting exercises for 6 min during infusion of either an angiotensin-converting enzyme inhibitor (enalapril), an ETA-receptor antagonist (BQ-123), or placebo. Retinal vessel diameters were measured continuously with the Zeiss retinal vessel analyzer. Systemic hemodynamics were assessed noninvasively, and intraocular pressure was measured with applanation tonometry. Squatting induced a significant increase in blood pressure and pulse rate, which was paralleled by a vasoconstriction in retinal arteries and veins. Intraocular pressure was only slightly increased during the squatting periods. BQ-123 significantly blunted the exercise-induced decrease in venous ( P < 0.01) and arterial ( P < 0.02, ANOVA) vessel diameters but had no effect on basal retinal diameters. By contrast, enalapril did neither influence vessel diameter at baseline conditions nor in response to isometric exercise. The data of the present study indicate that retinal vasoconstriction during isometric exercise is modified by ETA-receptor blockade, whereas it is not altered by angiotensin-converting enzyme inhibition. Hence, the present data indicate that endothelin-1, but not angiotensin II, is involved in retinal blood flow regulation during isometric exercise.
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Jeraj, Luka, Ana Spirkoska, Mateja Kaja Ježovnik, and Pavel Poredoš. "Deep vein thrombosis and properties of the arterial wall." Vasa 47, no. 3 (April 1, 2018): 197–202. http://dx.doi.org/10.1024/0301-1526/a000695.
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Abstract. Background: Deep vein thrombosis (DVT) affects more than one out of 1,000 people every year, of which 50 % develop post-thrombotic syndrome (PTS). Studies indicated that patients with DVT have deteriorated arterial wall function, while less is known about the association with PTS. We therefore investigated this relationship further. Patients and methods: A total of 120 patients treated for DVT of the lower extremity and a control group of 40 subjects without DVT were included. We assessed the presence of PTS using the Villalta scale. Flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) were calculated and reactive hyperaemia index (RHI) and augmentation index (AI) were obtained. Results: Patients with a history of DVT had lower FMD (4.0 % vs. 8.0 %, p < 0.001), lower NMD (12 % vs. 19 %, p = 0.001), and increased diameter of brachial artery (4.8 mm vs. 4.4 mm, p = 0.017). Peripheral arterial tonometry showed higher AI in patients with DVT (22.0 vs. 6.0, p = 0.004), while there was no difference in RHI. No differences in values between PTS-positive and PTS-negative patients were found. Conclusions: We confirmed the association between DVT and deteriorated functional properties of the arterial wall. Endothelial dysfunction of the large arteries, increased arterial stiffness, and increased diameter of the brachial artery were found in patients with DVT. However, there was no association between functional capability of the arterial wall and the incidence of PTS in DVT patients.
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Pinto, Fátima F., Sérgio Laranjo, Filipa Paramés, Isabel Freitas, and Miguel Mota-Carmo. "Long-term evaluation of endothelial function in Kawasaki disease patients." Cardiology in the Young 23, no. 4 (October 8, 2012): 517–22. http://dx.doi.org/10.1017/s1047951112001357.
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AbstractBackgroundKawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies. So far, the presence of endothelial dysfunction in patients with no coronary lesions has not been demonstrated. Peripheral arterial tonometry (Endo-PAT) measures the microvascular function in response to local ischaemia and has been validated in adult population, but its use in children is scarce.AimTo evaluate endothelial dysfunction in children as a long-term complication after Kawasaki disease using Endo-PAT.MethodsWe evaluated two groups of subjects: (1) Kawasaki disease patients over 11 years of age, diagnosed for >5 years, with no coronary lesions, or any other risk factors for cardiovascular disease; (2) control group of individuals without cardiovascular risk factors. Patients and controls were clinically accessed. Endo-PAT was performed to determine reactive hyperaemia index and augmentation index.ResultsA total of 35 individuals (21 males, age 21 ± 6 years) were evaluated (group 1: 19; controls: 16). Kawasaki disease patients presented significant lower reactive hyperaemia index (1.68 ± 0.49 versus 2.31 ± 0.53; p = 0.001). Augmentation index was similar in both groups (−10 ± 7 versus −11 ± 5; p > 0.005). Most patients with Kawasaki disease disclosed endothelial dysfunction (68%) compared with only 12% in controls.ConclusionsEndo-PAT is feasible and reproducible in the child population. Endothelial dysfunction is a frequent long-term complication in patients after Kawasaki disease with normal appearing coronary arteries. However, these results need validation in a larger population.
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PÍREK, O., K. BUDINSKAYA, and Z. NOVÁKOVÁ. "Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project." Physiological Research 71, Suppl. 2 (December 30, 2022): S203—S210. http://dx.doi.org/10.33549/physiolres.934997.
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Oral contraceptive pills (OCPs) have some strong advantages over more traditional types of contraception, including their consistently high contraceptive effect as well as multiple additional positive side effects. OCPs went through decades of intense pharmaceutical development and current formulas are well optimized – however, a handful of their negative side effects remain, including some that affect cardiovascular system, for example higher risk of hypertension, venous thromboembolism and increased arterial stiffness. The gold standard for arterial stiffness assessment is currently applanation tonometry, a method that relies on arterial pulse wave velocity measurement (PWV). Another possible method for arterial stiffness measurement is the use of the VaSera device, which measures cardio-ankle vascular index (CAVI). The aim of this study was to discover the effect of OCPs use on selected cardiovascular parameters related to arterial stiffness. We measured these cardiovascular parameters in the OCPs using group (OCP) and in the control group (CTRL) using applanation tonometer Sphygmocor and the VaSera device. Comparison of the data from both groups showed us significantly increased diastolic blood pressure (DBP) and carotid-radial pulse wave velocity (crPWV) as well as significantly lower subendocardial viability index (SVI) in the OCP. These results imply a negative effect of hormonal contraceptives on the cardiovascular system with most of the negative changes affecting the peripheral arteries. Despite this evidence supporting the hypothesis of OCPs having a negative effect on cardiovascular health, further research is necessary.
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de Marchi, Stefano F., Steffen Gloekler, Stefano F. Rimoldi, Patrizia Rölli, Hélène Steck, and Christian Seiler. "Microvascular response to metabolic and pressure challenge in the human coronary circulation." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 2 (August 2011): H434—H441. http://dx.doi.org/10.1152/ajpheart.01283.2010.
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In vivo observations of microcirculatory behavior during autoregulation and adaptation to varying myocardial oxygen demand are scarce in the human coronary system. This study assessed microvascular reactions to controlled metabolic and pressure provocation [bicycle exercise and external counterpulsation (ECP)]. In 20 healthy subjects, quantitative myocardial contrast echocardiography and arterial applanation tonometry were performed during increasing ECP levels, as well as before and during bicycle exercise. Myocardial blood flow (MBF; ml·min−1·g−1), the relative blood volume (rBV; ml/ml), the coronary vascular resistance index (CVRI; dyn·s·cm−5/g), the pressure-work index (PWI), and the pressure-rate product (mmHg/min) were assessed. MBF remained unchanged during ECP (1.08 ± 0.44 at baseline to 0.92 ± 0.38 at high-level ECP). Bicycle exercise led to an increase in MBF from 1.03 ± 0.39 to 3.42 ± 1.11 ( P < 0.001). The rBV remained unchanged during ECP, whereas it increased under exercise from 0.13 ± 0.033 to 0.22 ± 0.07 ( P < 0.001). The CVRI showed a marked increase under ECP from 7.40 ± 3.38 to 11.05 ± 5.43 and significantly dropped under exercise from 7.40 ± 2.78 to 2.21 ± 0.87 (both P < 0.001). There was a significant correlation between PWI and MBF in the pooled exercise data (slope: +0.162). During ECP, the relationship remained similar (slope: +0.153). Whereas physical exercise decreases coronary vascular resistance and induces considerable functional capillary recruitment, diastolic pressure transients up to 140 mmHg trigger arteriolar vasoconstriction, keeping MBF and functional capillary density constant. Demand-supply matching was maintained over the entire ECP pressure range.
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Shishkin, A. N., and A. I. Kniazeva. "Endothelial dysfunction in patients with obesity." Regional blood circulation and microcirculation 21, no. 3 (October 11, 2022): 4–11. http://dx.doi.org/10.24884/1682-6655-2022-21-3-4-11.
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Endothelial dysfunction has been considered in the pathogenesis of obesity widespread in the population. The purpose of this review was to provide updated information about pathogenetic features and markers of endothelial dysfunction in obese patients. We mentioned systemic disorders in obesity, such as oxidative stress, an increase in pro-inflammatory cytokines – tumor necrosis factor alpha, interleukin-6, and arginase activity. We also discussed the role of insulin resistance in the development of endothelial dysfunction, as well as the product of adipose tissue metabolism – monocyte chemoattractant protein-1. The participation of perivascular adipose tissue, hyperoxia of adipose tissue in the regulation of inflammation was considered. We illustrated the influence of atherogenic concentrations of oxidized low-density lipoproteins, the asymmetric dimethyl-L-arginine level on endothelial function. Changes in laboratory parameters were analyzed: endothelin-1, levels of microalbuminuria, homocysteine and uric acid. We also described cytological (circulating vascular cells, endothelial microparticles) and instrumental (endothelium-dependent vasodilation, peripheral arterial tonometry, intima-media complex thickness of the common carotid artery, ultrasound kidneys examination with duplex scanning of the renal arteries) methods for assessing endothelial function. Factors that influence the risk of cardiovascular complications were arterial hypertension and arterial stiffness, high levels of low-density lipoprotein and triglycerides, reduced physical activity. The determination of endothelial function in patients with obesity can be important for predicting the pathology of the cardiovascular system. Information on the assessment of markers of endothelial dysfunction in such patients may expand the possibilities of early diagnosis and prevention of cardiovascular complications.
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Cameron, J. D., and A. M. Dart. "Exercise training increases total systemic arterial compliance in humans." American Journal of Physiology-Heart and Circulatory Physiology 266, no. 2 (February 1, 1994): H693—H701. http://dx.doi.org/10.1152/ajpheart.1994.266.2.h693.
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Using a noninvasive technique we have investigated the effect of 4 wk of exercise training on total systemic arterial compliance (SAC) in 13 previously sedentary young males. SAC is assessed from simultaneous measurements of ascending aortic blood velocity using Doppler velocimetry and surrogate estimates of aortic root pressure obtained by applanation tonometry of the right carotid artery. Subsequent calibration of the pressure waveform is by linear interpolation against brachial arterial pressures measured sphygmomanometrically. Exercise training increased the overall mean maximum oxygen consumption (VO2 max) by 5.1 ml.min-1 x kg-1 (95% confidence limits 1.30–8.80, P < 0.01) and decreased mean systolic blood pressure by 8.4 mmHg [95% confidence interval (CI) 2.9–13.9, P < 0.01]. Mean SAC increased by 0.26 units (95% CI 0.10–0.43, P < 0.01) with the regional stiffness of the aortic arch (measured echocardiographically using the beta-index) showing a complementary decrease of 1.03 (95% CI -2.25–0.19, P < 0.05). Assuming a logarithmic arterial volume-pressure relationship, we were able to dissociate the change in SAC due to the exercise training-induced decrease in blood pressure from that due to change in the intrinsic compliance of the systemic arteries. Our results indicate that 1) exercise training increases SAC; 2) that the increase in SAC is greater than that due to changes in blood pressure and is likely to include a component due to change in intrinsic arterial compliance; and 3) that the induced change in SAC is linearly related to change in VO2 max.
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Tomoto, Tsubasa, Jun Sugawara, Yoshie Nogami, Kazutaka Aonuma, and Seiji Maeda. "The influence of central arterial compliance on cerebrovascular hemodynamics: insights from endurance training intervention." Journal of Applied Physiology 119, no. 5 (September 1, 2015): 445–51. http://dx.doi.org/10.1152/japplphysiol.00129.2015.
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Normally, central elastic arteries (e.g., aorta and common carotid artery) effectively buffer cardiac pulsation-induced flow/pressure fluctuations. With advancing age, arterial stiffening deteriorates this function and produces the greater cerebral hemodynamic pulsatility that impacts vulnerable brain tissue. It is well known that the buffering function of the central artery is improved by regular aerobic exercise, but the influence of endurance training on the pulsatile component of cerebral hemodynamics remains poorly understood. To characterize the functional role of the central artery at the heart-brain hemodynamic connection comprehensively, we assessed relations among the endurance training-induced changes in the left ventricle (LV), carotid arterial compliance, and cerebral hemodynamics. Thirteen collegiate tennis players (20 ± 1 yr) underwent a 16-wk endurance training intervention designed for improving cardiovascular function. Expectedly, maximal oxygen uptake (V̇o2peak), LV ejection velocity (via Doppler ultrasound), and the maximal rate of pressure increase of estimated aortic pressure waveform (via general transfer function) improved after the training intervention, whereas middle cerebral arterial (MCA) hemodynamics (via transcranial Doppler), such as mean and pulsatile flow velocities, remained unchanged. Carotid arterial compliance (via ultrasound and applanation tonometry) increased after the training intervention, and a larger increase in carotid arterial compliance was significantly associated with the greater attenuations of pulsatile MCA velocity ( r = −0.621) normalized by mean MCA velocity. These results suggest that the training-induced improvement of carotid artery Windkessel function might offset the expected increase in the pulsatile component of cerebral perfusion induced by the enhanced LV systolic function.
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Jaques, David A., Menno Pruijm, Daniel Ackermann, Bruno Vogt, Idris Guessous, Michel Burnier, Antoinette Pechere-Bertschi, Murielle Bochud, and Belen Ponte. "Sodium Intake Is Associated With Renal Resistive Index in an Adult Population-Based Study." Hypertension 76, no. 6 (December 2020): 1898–905. http://dx.doi.org/10.1161/hypertensionaha.120.15932.
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Renal resistive index (RRI) has been associated with adverse renal and cardiovascular outcomes. Although traditionally considered a marker of intrinsic renal damage, RRI could also reflect systemic vascular dysfunction. As sodium intake was linked to alterations in vascular properties, we wished to characterize the association of salt consumption with RRI in the general adult population. Participants were recruited in a population-based study in Switzerland. RRI was measured by ultrasound in 3 segmental arteries. Sodium intake (UNa; mmol/24 h) was estimated on 24-hour urine samples. Carotido-femoral pulse wave velocity was obtained by applanation tonometry. Mixed multivariate regression models were used with RRI or pulse wave velocity as independent variables and UNa as dependent variable, adjusting for possible confounders. We included 1002 patients in the analyses with 528 (52.7%) women and mean age of 47.2±17.4. Mean values of UNa and RRI were 141.8±61.1 mmol/24 h and 63.8±5.5%, respectively. In multivariate analysis, UNa was positively associated with RRI ( P =0.002) but not with pulse wave velocity ( P =0.344). Plasma renin activity and aldosterone did not modify the relationship between UNa and RRI ( P =0.087 for interaction). UNa/urinary potassium ratio was positively associated with pulse wave velocity ≥12 m/s ( P =0.033). Our results suggest that dietary salt consumption has a direct impact on renal hemodynamic in the adult general population. Alterations in vascular properties likely explain those findings, but inadequate renal vaso-motor response is also possible. Sodium intake could thus potentially be linked to underlying structural systemic damages affecting this population.