Academic literature on the topic 'TMD PDF'
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Journal articles on the topic "TMD PDF"
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Mrabet, Elyes, Mohamed Guedri, Mohamed Najib Ichchou, Samir Ghanmi, and Mohamed Soula. "A new reliability based optimization of tuned mass damper parameters using energy approach." Journal of Vibration and Control 24, no. 1 (March 9, 2016): 153–70. http://dx.doi.org/10.1177/1077546316636361.
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In this work a reliability based optimization (RBO) strategy of Tuned Mass Damper (TMD) parameters is presented. The strategy is based on an energetic approach. The strategy consists to optimize the TMD parameters so that we minimize the failure probability (objective function) characterized by the exceedence of the power dissipated in the primary structure of a certain threshold value during some interval time. The evaluation of the objective function is carried out using the classical Rice’s formula. The strategy is, firstly, applied to linear single-degree of freedom (SDOF) system, subjected to seismic motion, and then extended to linear multi-degree of freedom (MDOF) system. The use of the Rice’s formula requires the knowledge of the joint probability density function (PDF) of the considered processes; to this end, exact expression of the joint PDF is presented for the SDOF system and an approximation is presented for the evaluation of the failure probabilities for the MDOF system. By making use of the obtained joint PDF, for the SDOF system, as the a priori joint PDF, the approximation of the joint PDF, for the MDOF system, has been performed using the Minimum cross-entropy method (MinxEnt). To highlight the good effectiveness of the proposed strategy, a ten-story shear building, subjected to different earthquakes, is considered. The obtained results are compared with other from literature, and it has been shown the superiority of the proposed strategy.
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Hosseinkhani, H., M. Modarres, and N. Olanj. "Transverse momentum dependent (TMD) parton distribution functions generated in the modified DGLAP formalism based on the valence-like distributions." International Journal of Modern Physics A 32, no. 19n20 (July 12, 2017): 1750121. http://dx.doi.org/10.1142/s0217751x17501214.
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Transverse momentum dependent (TMD) parton distributions, also referred to as unintegrated parton distribution functions (UPDFs), are produced via the Kimber–Martin–Ryskin (KMR) prescription. The GJR08 set of parton distribution functions (PDFs) which are based on the valence-like distributions is used, at the leading order (LO) and the next-to-leading order (NLO) approximations, as inputs of the KMR formalism. The general and the relative behaviors of the generated TMD PDFs at LO and NLO and their ratios in a wide range of the transverse momentum values, i.e. [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] are investigated. It is shown that the properties of the parent valence-like PDFs are imprinted on the daughter TMD PDFs. Imposing the angular ordering constraint (AOC) leads to the dynamical variable limits on the integrals which in turn increase the contributions from the lower scales at lower [Formula: see text]. The results are compared with our previous studies based on the MSTW2008 input PDFs and it is shown that the present calculation gives flatter TMD PDFs. Finally, a comparison of longitudinal structure function [Formula: see text] is made by using the produced TMD PDFs and those that were generated through the MSTW2008-LO PDF from our previous work and the corresponding data from H1 and ZEUS collaborations and a reasonable agreement is found.
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Choudhury, D. K., and Baishali Saikia. "Parton Distribution Functions and models of proton structure functions with self-similarity." International Journal of Modern Physics A 31, no. 34 (December 6, 2016): 1650176. http://dx.doi.org/10.1142/s0217751x16501761.
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Sometime back, a self-similarity based model of the proton structure function at small [Formula: see text] was proposed by Lastovicka. We make reanalysis of this model with most recent HERA data. No significance difference with the earlier analysis is found. Both the analyses have singularity within the kinematical range of [Formula: see text]: [Formula: see text]. We therefore study the model with the additional assumption that it should be singularity free, imposing positivity conditions on the model parameters. This results in a new model which is, however, phenomenologically valid only in a limited low [Formula: see text] range. We therefore make further generalization of the defining self-similar unintegrated Parton Density Function (uPDF) and show that the with proper generalizations and initial conditions on them not only remove the undesired singularity but also results in a structure function with logarithmic growth in [Formula: see text] closer to QCD. The phenomenological range of validity is then found to be much larger than the earlier versions. We also extrapolate the models to large [Formula: see text] in a parameter-free way. The possibility of incorporation of Transverse Momentum Dependent (TMD) PDF in this approach is explored as well.
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Mulders, P. J., and M. G. A. Buffing. "Wilson Lines off the Light-Cone in TMD PDFs." Few-Body Systems 55, no. 5-7 (March 9, 2014): 275–86. http://dx.doi.org/10.1007/s00601-014-0843-1.
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TAMBORLANE, WILLIAM V., PEIYAO CHENG, ROBIN L. GAL, CRAIG KOLLMAN, MICHELLE A. VAN NAME, JANE L. LYNCH, and BRYCE A. NELSON. "T1D and T2D Youth in the Pediatric Diabetes Consortium (PDC) Registries—Comparing Clinical Characteristics and Glycemic Control." Diabetes 67, Supplement 1 (May 2018): 1340—P. http://dx.doi.org/10.2337/db18-1340-p.
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Teh, Jun Liang, and Anthony Yuen Bun Teoh. "Techniques and Outcomes of Endoscopic Ultrasound Guided—Pancreatic Duct Drainage (EUS- PDD)." Journal of Clinical Medicine 12, no. 4 (February 17, 2023): 1626. http://dx.doi.org/10.3390/jcm12041626.
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Endoscopic ultrasound guided—pancreatic duct drainage (EUS- PDD) is one of the most technically challenging procedures for the interventional endoscopist. The most common indications for EUS- PDD are patients with main pancreatic duct obstruction who have failed conventional endoscopic retrograde pancreatography (ERP) drainage or those with surgically altered anatomy. EUS- PDD can be performed via two approaches: the EUS-rendezvous (EUS- RV) or the EUS-transmural drainage (TMD) techniques. The purpose of this review is to provide an updated review of the techniques and equipment available for EUS- PDD and the outcomes of EUS- PDD reported in the literature. Recent developments and future directions surrounding the procedure will also be discussed.
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Pernkopf, D. G., G. Untergasser, P. Berger, and E. Plas. "Phosphodiesterase (PDE) inhibitors reduce in vitro proliferation of prostate primary cells but do not interfere with growth of prostate carcinoma cell lines." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 14604. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14604.
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14604 Background: PDE 5 is highly expressed in cavernosal and prostatic tissue. The mechanism of PDE-5 inhibitors on cavernosal tissue is well established but the effects of PDE-5 inhibitors on prostatic cells are unknown. The aim of this study was to analyze in vitro effects of PDE-5 inhibitors on prostate primary cells, fibroblasts (PrSC), basal epithelial cells (PrEC) and prostate cancer cell lines. Methods: Cultivated PrEC and PrSC, immortalized BPH cells (BPH 1), androgen dependent (LNCaP) and androgen independent (PC3) prostate carcinoma cell lines were exposed to increasing concentrations of commercially available PDE 5 inhibitors Sildenafil (Sil), Tadalafil (Tad), Vardenafil (Var). After incubation for 3 days cell viability was determined by a WST-1 assay (Roche-Biochemicals). Cells were evaluated morphologically by invert-light microscopy. PDE-5 protein concentrations were determined by western blot analyses and tissue distribution of PDE-5 by immunohistochemistry (IHC) with a polyclonal antiserum. Results: None of the PDE-5 inhibitors induced cell proliferation. Significant decreases in proliferation and viability were observed at high concentrations (1 mg/ml) of all substances in PrSC and PrEC. In PrSC, proliferation rate decreased to 37.7% in Sil, to 16.9% in Tad and to 63.7% for Var as compared to controls. In PrEC, proliferation decreased to 72.7%, 21.6% and 84.4% for Sil, Tad and Var, respectively. At 0.1 mg/ml only Tad reduced proliferation significantly to 57.4%. Moreover, Tad induced neuroendocrine-like morphology in some PrEC. High protein concentrations of PDE 5 were observed in PrEC, low concentrations in PrSC but none in cancer cells. Conclusions: Sil, Tad and Var inhibit proliferation of prostate primary cells in vitro. Tad showed highest inhibition. Tumor cells were insensitive to PDE-5 inhibitors, due to the lack of PDE-5 protein. It seems unlikely that any of these substances increases proliferation of prostate carcinoma. Tad induced neuroendocrine-like morphology in some basal PrEC indicating effects on cellular differentiation. No significant financial relationships to disclose.
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BUDIMAN, Harry, and Oman ZUAS. "VALIDATION OF ANALYTICAL METHOD FOR DETERMINATION OF HIGH LEVEL CARBON DIOXIDE (CO2) IN NITROGEN GAS (N2) MATRIX USING GAS CHROMATOGRAPHY THERMAL CONDUCTIVITY DETECTOR." Periódico Tchê Química 12, no. 24 (August 20, 2015): 7–16. http://dx.doi.org/10.52571/ptq.v12.n24.2015.7_p_24_pgs_7_16.pdf.
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High accurate result of carbon dioxide (CO2) measurement is of great importance since the result (data) is used as the foundation for decision making related to regulated monitoring program and law enforcement. In this study, therefore, method for measurement of high level of carbon dioxide (CO2) in nitrogen (N2) matrix using gas chromatography thermal conductivity detector (GC-TCD) was validated to achieve the optimum performance of the method. For this purposes, identity confirmation, selectivity, limit of detection (LoD), limit of quantitation (LoQ), repeatability, reproducibility, accuracy, and linearity of the method were evaluated. The result shows that the GC-TCD method has good precision in term of repeatability and reproducibility having values of 0.07 and 0.37%, respectively. No bias of the method can be found and an excellent linearity of the method was obtained in the range of 2 - 13.97% mol/mol. Thus, based on the result evaluation under given criteria of this study, it can be concluded that the GC-TCD method is reliable and suitable for determination of high level of CO2 in N2 matrix.
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Starobinski, D., A. Trachtenberg, and S. Agarwal. "Efficient PDA synchronization." IEEE Transactions on Mobile Computing 2, no. 1 (January 2003): 40–51. http://dx.doi.org/10.1109/tmc.2003.1195150.
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Dey, Sonjoy, Shakir Bin Mujib, and Gurpreet Singh. "Enhanced Li-Ion Rate Capability and Stable Efficiency Enabled by MoSe2 Nanosheets in Polymer-Derived Silicon Oxycarbide Fiber Electrodes." Nanomaterials 12, no. 3 (February 6, 2022): 553. http://dx.doi.org/10.3390/nano12030553.
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Transition metal dichalcogenides (TMDs) such as MoSe2 have continued to generate interest in the engineering community because of their unique layered morphology—the strong in-plane chemical bonding between transition metal atoms sandwiched between two chalcogen atoms and the weak physical attraction between adjacent TMD layers provides them with not only chemical versatility but also a range of electronic, optical, and chemical properties that can be unlocked upon exfoliation into individual TMD layers. Such a layered morphology is particularly suitable for ion intercalation as well as for conversion chemistry with alkali metal ions for electrochemical energy storage applications. Nonetheless, host of issues including fast capacity decay arising due to volume changes and from TMD’s degradation reaction with electrolyte at low discharge potentials have restricted use in commercial batteries. One approach to overcome barriers associated with TMDs’ chemical stability functionalization of TMD surfaces by chemically robust precursor-derived ceramics or PDC materials, such as silicon oxycarbide (SiOC). SiOC-functionalized TMDs have shown to curb capacity degradation in TMD and improve long term cycling as Li-ion battery (LIBs) electrodes. Herein, we report synthesis of such a composite in which MoSe2 nanosheets are in SiOC matrix in a self-standing fiber mat configuration. This was achieved via electrospinning of TMD nanosheets suspended in pre-ceramic polymer followed by high temperature pyrolysis. Morphology and chemical composition of synthesized material was established by use of electron microscopy and spectroscopic technique. When tested as LIB electrode, the SiOC/MoSe2 fiber mats showed improved cycling stability over neat MoSe2 and neat SiOC electrodes. The freestanding composite electrode delivered a high charge capacity of 586 mAh g−1electrode with an initial coulombic efficiency of 58%. The composite electrode also showed good cycling stability over SiOC fiber mat electrode for over 100 cycles.
Dissertations / Theses on the topic "TMD PDF"
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Takekawa, Stefano. "Study of T-odd parton distribution functions in polarised Drell-Yan processes at COMPASS." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3722.
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2008/2009Lo studio di processi di Drell-Yan (DY) polarizzato permette di accedere alle funzioni di distribuzione partoniche dipendenti dal momento intrinseco trasverso (TMD PDF) che sono usate per descrivere la struttura del protone. La proposta di misura di T-odd TMD PDF (funzioni di Sivers e di Boer-Mulders) è in scrittura e verrà presentata all'SPS Committee. Essa illustra l'intezione di usare lo spettrometro dell'esperimento COMPASS al CERN per effettuare questa misura studiando eventi di Drell-Yan polarizzato. Simulazioni di Monte Carlo sono state effettuate e sono riportate le analisi dei dati raccolti durante i test di DY svolti alla fine dei run di COMPASS degli anni 2007, 2008 e 2009.
The study of Drell-Yan (DY) processes allows to access to the transverse momentum dependent parton distribution functions (TMD PDF) which are used to describe the structure of the proton. The proposal of measure of T-odd TMD PDF (Sivers and Boer-Mulders functions) has been written and it will be submitted to the SPS Committee. It is about the use of the COMPASS spectrometer at CERN to perform this measure via Drell-Yan processes. Monte Carlo simulations were done and the analysis of the data collected during the DY test at the end of 2007, 2008 and 2009 runs are reported.
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Filho, José Dirceu Vollet. "\"Identificação e quantificação de fotossensibilizador em tecido hepático por espectroscopia de fluorescência e sua importância na terapia fotodinâmica\"." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-28032007-180658/.
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A Terapia Fotodinâmica (TFD) é uma técnica que provoca dano celular pela ação de um fotossensibilizador (FS), com seletividade de localização em tecido tumoral; a luz que, absorvida pelo FS, leva-o a um estado tripleto metaestável; e oxigênio molecular, o qual recebe a energia absorvida pelo FS, passando a um estado singleto de alta capacidade oxidativa. A técnica é bem sucedida no tratamento de lesões como câncer, mas enfrenta, entretanto, dificuldades para a determinação de sua dosimetria. Uma delas é a quantificação da distribuição do FS no tecido tratado. Este trabalho tem três objetivos: a obtenção de informação quantitativa por espectros de fluorescência de fluoróforos em meios turvos; a demonstração da distribuição do FS Photogem® em fígados sadios de ratos Wistar e suas implicações na dosimetria; e a melhoria de um dos modelos existentes para previsão da profundidade de necrose (Ynec), importante parâmetro no estudo da TFD. Realizaram-se os experimentos em três fases: na primeira, tentou-se reconstruir o espectro do fígado sadio a partir de uma composição de espectros isolados de fluoróforos endógenos do fígado. Na segunda, realizaram-se estudos com corantes alimentícios Coralim-Mix® nas cores azul, verde e vermelho e com corantes Exciton® (Coumarin-480 e LDS-722) in vitro e in vivo, visando identificar os espectros dos corantes em misturas com meios turvos e entre eles. Na terceira, aplicou-se Photogem® em ratos Wistar e se coletou a fluorescência do FS nos fígados, relacionando-se a variação na intensidade de fluorescência com a concentração de FS presente e com perfis de necrose obtidos por TFD. Aplicou-se, por fim, os resultados obtidos na melhoria do modelo para previsão da Ynec. A reconstrução dos espectros não foi bem sucedida, tal qual a recuperação dos espectros dos corantes. Os resultados mostraram que muitos fatores contribuem para a distorção da fluorescência coletada, e que a informação obtida é prejudicada se estes forem ignorados. Verificou-se que a distribuição do FS não é homogênea num órgão fotossensibilizado. Obteve-se uma função para distribuição do FS no tecido e, através dela, foi possível melhorar o modelo para a previsão da Ynec. Observou-se que a turbidez do meio afeta de maneira complexa a coleta de fluorescência, criando obstáculos para a quantificação direta de fluoróforos nele inseridos. Fica evidente a necessidade do aprofundamento dos estudos sobre a interação da luz com as partículas dos meios turvos para remover as distorções geradas por estas. Demonstrou-se ainda a importância do mapeamento da distribuição do FS num tecido fotossensibilizado como parte da dosimetria da TFD, e que a espectroscopia de fluorescência é forte candidata à técnica mais apropriada para este mapeamento, desde que dominados os obstáculos à coleta de fluorescência.Photodynamic Therapy (PDT) is a technique that implies in cell damage by the action of a photosensitizer (PS) with tumor tissue localization selectivity; light at PS absorption spectrum wavelengths, which leads the PS to a metastable triplet state; and molecular oxygen, which earns the energy absorbed by the PS, reaching a high oxidative potential singlet state. The technique has found sucess on the treatment of lesions as cancer. However, it finds difficulties for its dosimetry stablishment, like the quantification of PS distribuition in a photosensitized tissue. This work has three purposes: obtainance of fluorophores quantitative information into turbid media through fluorescence spectroscopy; to show the distribution of the PS Photogem® in healthy Wistar rats livers and its consequences on dosimetry; and the upgrade of an existing model for depth of necrosis (Ynec) forecast. There were three experimental stages: the first one was an attemp to rebuild a healthy liver spectrum from a composition using mathematical weights for isolate liver endogenous fluorophores spectra. On the second stage, in vitro and in vivo studies were performed using Coralim-Mix® blue, green and red food dyes and the Exciton® dyes Coumarin-480 and LDS-722, aiming to recover dyes spectra from dyes in turbid solutions and dyes mixtures. On the third one, Photogem® was administered to Wistar rats and fluorescence was collected on rats livers, and a relationship was stablished between the changes on fluorescence intensity, PS concentration in the tissue and necrosis profiles obtained via PDT. Results were applied to the upgrade of the Ynec forecast model. Spectra rebuilding, as well as dyes spectra recovering, were not completely reached. Results showed that a great deal of factors contribute to distortions at the collected fluorescence. It was verified that PS distribution is inhomogeneous in a photosensitized organ. It was found a function for the PS tissue distribution and it made possible to upgrade the Ynec forecast model. It was showed that medium turbidity affects in a complex manner the collected fluorescence, making difficult to quantify directly fluorophores in such medium. A need to go deeper into the investigation of light interactions with turbid media so that we may remove distortions they introduce into fluorescence spectra became evident. It was also showed how important is to track PS distribuition in a photosensitized tissue as a part of PDT dosimetry, and how fluorescence spectroscopy seems to be appropriate to perform such tracking, as long as the difficulties on fluorescence collection are overcome.
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Castex, Elodie Grasland Loïc. "Le transport à la demande (TAD) en France." Villeurbanne : TEL, 2008. http://tel.archives-ouvertes.fr/docs/00/26/87/13/PDF/These.E.Castex_2007_V2.pdf.
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Perez, Priego Juan Gabriel. "Ad-Hoc Sharing for Palm Devices." ScholarWorks@UNO, 2005. http://scholarworks.uno.edu/td/239.
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The current generation of Palm PDA devices is designed to share information records primarily with a base desktop system, or a server. Therefore, their built- in features for sharing data during ad-hoc collaboration among groups of mobile users are inadequate. In this thesis, we describe a new framework that addresses this problem by allowing users to transparently share the record databases of common applications during spontaneous collaborative sessions. The framework also allows users to define custom sharing policies for each application/user pair. These policies determine the manner in which records are exchanged and update, thereby automating the process of handling conflicts and preserving user privacy preferences. We also present implementation results, in which we have used the framework to create shared versions of common applications, such as Calendar and Memo. Our experimental results show that the programming effort involved is minimal and the user interaction with the application is, essentially, the same as in the original application.
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Castex, Elodie. "Le Transport A la Demande (TAD) en France : de l'état des lieux à l'anticipation. Modélisation des caractéristiques fonctionnelles des TAD pour développer les modes flexibles de demain." Phd thesis, Avignon, 2007. http://tel.archives-ouvertes.fr/docs/00/26/87/13/PDF/These.E.Castex_2007_V2.pdf.
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Le Transport à la Demande (TAD) est à un mode de transport public à mi-chemin entre le taxi et le bus. Longtemps considéré comme un mode marginal réservé aux espaces peu denses, le TAD connaît un fort développement en France et plus généralement en Europe depuis la fin des années 1990, Il ressort de l'analyse d'une base de données de 615 services, que les TAD français investissent désormais de nouveaux territoires, aussi bien dans les réseaux urbains, périurbains que les espaces ruraux, Les prestations qu'ils proposent se caractérisent par une grande variété d'offre et de fonctionnement, Celles-ci sont décrites à l'aide de plusieurs modélisations fontionnelles, statistiques et graphiques. Une réflexion sur la flexibilité des TAD, ainsi qu'une enquête, viennent ensuite nourrir le débat sur les TAD de demain. Trois exemples illustrent les perspectives qu'ouvre la généralisation de TAD flexibles et innovants en matière de transport public pour les collectivitésDemand Responsive Transport (DRT) is a type of public transportation which combines the advantages of collective transport and taxi. It has often been considered as a marginal means of transportation reserved to low density territories. Since the end of 90s, the number of DRT services has increased regularly. A database of 615 services shows that DRT services invest new territories such as urban, suburban or rural spaces. They offer a large variety of operating services, which are described by using several models we designed (functional, statistical and graphical models). The last part of the thesis is devoted to the flexibility of the DRT, a survey is analysed to discuss the reliability of future DRT services. Three examples illustrate the flexible DRT potentialities for public transportation networks
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Ustunel, Eser Kwon Hyuck M. "Time division duplex-wideband code division multiplex (TDD-WCDMA)." Diss., Click here for available full-text of this thesis, 2006. http://library.wichita.edu/digitallibrary/etd/2006/t029.pdf.
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Thesis (M.S.)--Wichita State University, Electrical and Computer Engineering."May 2006." Title from PDF title page (viewed on October 19, 2006). Thesis adviser: Hyuck M. Kwon. Includes bibliographic references (leaves 40-42).
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Nebbe, Brian. "Adolescent facial morphology and TMJ internal derangement." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0002/NQ29085.pdf.
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Rossmanith, David A. Jr. "Poroacuatics Under Brinkman's Model." ScholarWorks@UNO, 2016. http://scholarworks.uno.edu/td/2183.
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Through perturbation analysis, a study of the role of Brinkman viscosity in the propagation of finite amplitude harmonic waves is carried out. Interplay between various parameters, namely, frequency, Reynolds number and beta are investigated. For systems with physically realizable Reynolds numbers, departure from the Darcy Jordan model (DJM) is noted for high frequency signals. Low and high frequency limiting cases are discussed, and the physical parameters defining the acoustic propagation are obtained.
Through numerical analyses, the roles of Brinkman viscosity, the Darcy coefficient, and the coefficient of nonlinearity on the evolution of finite amplitude harmonic waves is stud- ied. An investigation of acoustic blow-ups is conducted, showing that an increase in the magnitude of the nonlinear term gives rise to blow-ups, while an increase in the strength of the Darcy and/or Brinkman terms mitigate them. Finally, an analytical study via a regular perturbation expansion is given to support the numerical results.
In order to gain insight into the formation and evolution of nonlinear standing waves un- der the Brinkman model, a numerical analysis is conducted on the weakly nonlinear model based on Brinkman’s equation. We develop a finite difference scheme and conduct a param- eter study. An examination of the Brinkman, Darcy, and nonlinear terms is carried out in the context of their roles on shock formation. Finally, we compare our findings to those of previous results found in similar nonlinear equations in other fields.
So as to better understand the behavior of finite-amplitude harmonic waves under a Brinkman-based poroacoustic model, approximations and transformations are used to recast the Brinkman equation into the damped Burger’s equation. An examination is carried out for the two special solutions of the damped Burger’s equation: the approximate solution to the damped Burger’s equation and the boundary value problem given an initial sinusoidal pulse. The effects of the Darcy coefficient, Reynolds number, and nonlinear coefficient on these solutions are investigated.
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Longstaffe, Margery A. "The prophet unmasked, the poetry of Ted Hughes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0008/MQ33247.pdf.
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Mora, Espí Inmaculada. "Photosensitizers and microparticles as tools against malignant cells." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664179.
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En els últims anys, s’han desenvolupat diverses estratègies per destruir específicament cèl·lules canceroses i minimitzar els efectes secundaris sobre cèl·lules sanes. Una d’estes estratègies és la teràpia fotodinàmica (PDT), una tècnica que utilitza un fotosensibilitzant (PS) juntament amb una longitud d’ona concreta, en presència d’oxigen. En excitar el PS es produïxen espècies reactives de l’oxigen (ROS) que matarien les cèl·lules del voltant. Per dirigir selectivament els PSs cap a les cèl·lules diana, estos es poden vehicular en nano- i micropartícules (NPs i µPs, respectivament). En eixe sentit, biofuncionalitzar NPs o µPs amb PSs y molècules capaces de reconéixer les cèl·lules malignes hauria de permetre fer tractaments més selectius amb PDT. Altra estratègia per destruir cèl·lules malignes és l’ús d’altres fàrmacs terapèutics que interaccionen amb dianes intracel·lulars per induir la mort cel·lular. Estos fàrmacs també poden ser vehiculitzats en NPs o µPs per dirigir-los més eficientment a les cèl·lules diana, però la major limitació d’este enfoc és que després de la internalització poden quedar atrapades junt als seus vehicles al compartiment endolisosomal. Per superar este problema, s’han desenvolupat estratègies com la internalització fotoquímica (PCI), que es basa en els mateixos principis que la PDT però, en este cas, el PS s’acumula en les membranes endolisosomals, que patixen disrupció despuix de l’excitació del PS, permetent l’alliberació del contingut endolisosomal cap al citosol.
L’objectiu de la present tesi és contribuir al desenvolupament de les estratègies mencionades prèviament per eliminar selectivament cèl·lules malignes. En el primer treball, els tractaments fotodinàmics amb dos PSs (Na-H2TCPP i el seu derivat de zinc Na-ZnTCPP) induïren un descens en la supervivència de cèl·lules tumorals (SKBR3) i no tumorals (MCF10A), encara que este últimes mostraren una major resistència a baixes concentracions dels dos PSs. A més, depenent del PS i la línia cel·lular es van desencadenar diferents mecanismes de mort cel·lular, fet que podria explotar-se per protegir selectivament les cèl·lules no malignes en front dels tractaments fotodinàmics. En el segon treball es va demostrar que HER2, sobreexpressat en cèl·lules d’alguns tipus de càncer, era una diana adequada per dirigir µPs biofuncionalitzades amb anti-HER2. També demostràrem que diferents condicions de cultiu (monocultius o cocultius en sistemes estàtics o microfluídics) influenciaven la internalització de les µPs, posant en relleu la importància de realitzar estudis sobre les interaccions entre µPs i cèl·lules en condicions més similars a les existents in vivo. Finalment, en el nostre tercer treball observàrem que la PCI induïx eficaçment la disrupció de les membranes endolisosomals, permetent l’alliberació de molècules solubles cap al citosol, però no una desintegració completa de la membrana, fet que seria necessari per l’alliberació de les µPs atrapades.
En conclusió, la present tesi proporciona nou coneiximent pel desenvolupament de millors agents terapèutics y tractaments basats en l’ús de PSs i µPs per la destrucció selectiva de cèl·lules malignes.En los últimos años, se han desarrollado diversas estrategias para destruir específicamente células cancerosas y minimizar los efectos secundarios en células sanas. Una de estas estrategias es la terapia fotodinámica (PDT), una técnica que utiliza un fotosensibilizante (PS) y luz de una longitud de onda concreta, en presencia de oxígeno. Cuando el PS es excitado por la luz, produce especies reactivas del oxígeno (ROS) que inducen la muerte de las células circundantes. Para dirigir selectivamente los PSs hacia las células diana, éstos pueden vehiculizarse en nano- y micropartículas (NPs y µPs, respectivamente). En este sentido, biofuncionalizar NPs o µPs con PSs y con moléculas capaces de reconocer las células malignas debería permitir hacer tratamientos más selectivos con PDT. Otra estrategia para destruir células malignas es el uso de otros fármacos terapéuticos que interaccionen con dianas intracelulares para matar la célula. Estos fármacos también pueden ser vehiculizados en NPs o µPs para dirigirlos con más eficiencia a las células diana, pero la mayor limitación de este enfoque es que tras la internalización pueden quedar atrapados junto a sus vehículos en el compartimento endolisosomal. Para superar este problema, se han desarrollado estrategias como la internalización fotoquímica (PCI), que se basa en los mismos principios que la PDT pero, en este caso, el PS se acumula en las membranas endolisosomales, que sufren una disrupción tras la excitación del PS, permitiendo la liberación del contenido endolisosomal hacia el citosol. El objetivo de la presente tesis es contribuir al desarrollo de las estrategias mencionadas previamente, para eliminar selectivamente células malignas. En el primer trabajo, los tratamientos fotodinámicos con dos PSs (Na-H2TCPP y su derivado de zinc Na-ZnTCPP) indujeron un descenso en la supervivencia de células tumorales (SKBR3) y no tumorales (MCF10A), aunque éstas últimas mostraron mayor resistencia a bajas concentraciones de ambos PSs. Además, según el PS y la línea celular se desencadenaron diferentes mecanismos de muerte celular, hecho que podría explotarse para proteger selectivamente las células no malignas durante los tratamientos fotodinámicos. En el segundo trabajo, se demostró que HER2, sobreexpresado en células de algunos tipos de cáncer, era una diana adecuada para dirigir µPs biofuncionalizadas con anti-HER2. También demostramos que diferentes condiciones de cultivo (mono o cocultivos en sistemas estáticos o microfluídicos), influenciaban la internalización de las µPs, lo que puso de relieve la importancia de realizar estudios sobre las interacciones entre µPs y células en condiciones más similares a las existentes in vivo. Finalmente, en nuestro tercer trabajo observamos que la PCI induce eficazmente la disrupción de las membranas endolisosomales, permitiendo la liberación de moléculas solubles hacia el citosol, pero no una desintegración completa de la membrana, lo que sería necesario para la liberación de las µPs atrapadas. En conclusión, la presente tesis proporciona nuevo conocimiento para el desarrollo de mejores agentes terapéuticos y tratamientos basados en el uso de PSs y µPs para la destrucción selectiva de células malignas.
In the last years, different strategies have been developed to specifically destroy cancer cells minimizing side effects on healthy ones. One of these strategies is photodynamic therapy (PDT), a technique that uses a photosensitizer (PS) in combination with a specific wavelength in the presence of oxygen. When the PS is excited, reactive oxygen species (ROS) are produced, which would kill the surrounding cells. To selectively direct PSs to target cells, they can be attached to drug carries, like nano- and microparticles (NPs and µPs, respectively). In this way, biofunctionalizing NPs or µPs with PSs and molecules able to recognize malignant cells would improve cell targeting, increasing the effectivity of PDT. Another strategy to destroy malignant cells is the use of other therapeutic drugs that interact with intracellular targets to kill the cell. These drugs can also be carried by NPs or µPs to improve cell targeting, but the main limitation of this approach is their entrapment in the endolysosomal compartment after internalization by cells. To overcome this problem, escape enhancing strategies have been developed, like photochemical internalization (PCI), which is based in the same principles as PDT, but in this case the PS must accumulate in the endolysosomal membranes. In this way, disruption of the endolysomal membranes after PS excitation would allow the release of the endocytosed cargo. The aim of the present thesis is to contribute in the development of the aforementioned strategies for the selective destruction of malignant cells. In the first work, photodynamic treatments with two PSs (Na-H2TCPP and its zinc derivative Na-ZnTCPP) were found to induce a decrease in cell survival in both tumoral (SKBR3) and non-tumoral (MCF10A) cells, though the latter showed higher resistance at low PSs concentrations. Moreover, different cell death mechanisms were triggered depending on both the PS and the cell line, a result that could be exploited to selectively protect non-malignant cells in photodynamic treatments. In a second work, HER2 was found to be a suitable target to direct anti-HER2 biofunctionalized µPs to a tumorigenic cell line overexpressing this receptor. We also demonstrated that different culture conditions (monoculture or coculture in static or microfluidics systems) influenced µPs internalization, emphasising the importance of performing in vitro studies on cells- µPs interactions in an environment more similar to in vivo conditions (cocultures in microfluidic systems). Finally, in our third work, we found that PCI effectively induces endolysosomal membrane disruption, allowing the release of soluble molecules into the cytosol, but not complete membrane disintegration, which would be needed for the release of entrapped µPs. In conclusion, the present thesis provides new knowledge towards the development of better therapeutic agents and treatments based on the use of PSs and µPs for the selective destruction of malignant cells.
Books on the topic "TMD PDF"
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Goodman, Wayne K., and Mark S. George. Neuromodulation and Psychiatric Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0010.
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An increasing number of approaches permit psychiatrists to directly stimulate the brain. Such therapies are sometimes referred to as neuromodulation, as psychiatrists can either excite or inhibit neuronal firing in the brain. This chapter reviews two such technologies—transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS). Both techniques have FDA approval and are moving into mainstream therapeutic use. Daily prefrontal TMS for 4–6 weeks is FDA approved for treating depression, with minimal side effects. It is now accepted in most treatment algorithms as an approach for patients who have not responded to medications or talking therapy. DBS has virtually replaced ablative neurosurgery for use in medication-refractory movement disorders such as Parkinson’s Disease (PD), where it has the advantages of being reversible (explantable) and adjustable. DBS is now being studied in severe psychiatric conditions, such as intractable obsessive-compulsive disorder (OCD) and treatment resistant depression (TRD).
Book chapters on the topic "TMD PDF"
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Rischin, Danny. "Biomarkers for Immune Modulatory Treatment in Head and Neck Squamous Cell Carcinoma (HNSCC)." In Critical Issues in Head and Neck Oncology, 83–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_6.
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AbstractImmune checkpoint inhibitors have changed the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, only a minority of patients respond, hence the search for predictive biomarkers. Potential predictive biomarkers for immune checkpoint inhibitors discussed in this chapter include (1) Immune checkpoint ligand expression e.g., PD-L1, (2) biomarkers of a T-cell inflamed tumour microenvironment (TME) such as gene expression profiles of activated T cells, (3) biomarkers of tumour neoepitope burden such as tumour mutation burden (TMB) and (4) multidimensional quantitative techniques. At present only PD-L1 expression has been shown to have clinical utility in head and neck cancer. It enriches for populations more likely to respond, but the false positive predictive value remains high. In the pivotal Keynote−048 trial that established a role for pembrolizumab (anti-PD1) monotherapy and pembrolizumab + chemotherapy as treatment options in first-line R/M HNSCC, primary endpoints included overall survival in defined subgroups based on PD-L1 expression. In this trial the combined positive score (CPS) was used which takes into account PD-L1 expression in tumour and immune cells. Based on this trial regulatory approvals for first-line pembrolizumab in R/M HNSCC require assessment of PD-L1 expression using the CPS. Finally we discuss emerging evidence that locoregionally advanced HPV-associated oropharyngeal cancers that have high expression of CD103 positive CD8 T cells have an excellent prognosis and features that suggest increased probability of responding to anti-PD1/PD-L1, raising the possibility of incorporating these immune therapies as part of a de-escalation trial strategy.
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Kerstein, DMD, Robert B. "Employing the T-Scan/BioEMG III Synchronized Technologies to Diagnose and Treat Chronic Occluso-Muscle Disorder." In Advances in Medical Technologies and Clinical Practice, 362–514. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-5225-9254-9.ch007.
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This chapter discusses chronic occluso-muscle disorder, which is a myogenous subset of temporomandibular disorder (TMD) symptoms resultant from occlusally activated muscle hyperactivity. It also describes the computer-guided occluso-muscle disorder treatment known as disclusion time reduction (DTR), that studies repeatedly show reduces many common muscular temporomandibular disorder symptoms. T-Scan-based research since 1991 has determined that a significant etiologic component of occluso-muscle disorder is prolonged (in time) occlusal surface friction shared between opposing posterior teeth during mandibular excursions, that occurs in both normal chewing function and during parafunction. This friction results in prolonged compressions of the periodontal ligament (PDL) fibers of the involved teeth, which when in excursive opposing occlusal contact, also experience pulpal flexure that leads to pulpal neural activation, which together with the periodontal ligament compressions, trigger excess muscle contractions within the masticatory muscles. It is this unique neuroanatomy that incites and perpetuates many chronic muscular TMD symptomatology, that can be readily resolved in patients that meet the diagnostic criteria for DTR candidacy, using the ICAGD coronoplasty that is performed in the maximum intercuspal position (MIP), without employing treatment splints, deprogrammers, appliances, orthotics, or mandibular repositioning. Additionally, this chapter will highlight the newest disclusion time reduction therapy (DTR) studies that support the clinical implementation of this highly effective measured occlusal treatment for occluso-muscle disorder.
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Wilson, Kelly G., Steven C. Hayes, Jennifer Gregg, and Robert D. Zettle. "Psicopatología y psicoterapia." In Teoría del marco relacional: Un enfoque postskinneriano de la cognición y el lenguaje humanos, edited by Javier Virues-Ortega and Agustín Pérez-Bustamante Pereira, translated by Javier Virues-Ortega and Agustín Pérez-Bustamante Pereira, 279–316. ABA España, 2021. http://dx.doi.org/10.26741/978-84-09-31730-1_12.
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En este capítulo, centraremos nuestra atención sobre el amplio campo de la psicopatología y la psicoterapia. Consideraremos varias tradiciones en psicopatología, incluyendo la sindrómica, la biológica y la de los diagnósticos funcionales. Tras ello, nos centraremos en detalle en el enfoque del diagnóstico funcional para ilustrar un enfoque desde la TMR sobre la psicopatología. Posteriormente, consideraremos cómo la TMR puede contribuir en la psicoterapia, especialmente en cómo puede interconectarse con la nueva ola de terapias de conducta (es decir, el análisis clínico de la conducta), que incluye la Terapia de Aceptación y Compromiso (ACT), la Psicoterapia Analítico Funcional (PAF), la Terapia Dialéctica Conductual (TDC) y la Terapia Integral de Pareja (TIP)...
Conference papers on the topic "TMD PDF"
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Vladimirov, Alexey. "TMD PDFs in the Laguerre polynomial basis." In XXII. International Workshop on Deep-Inelastic Scattering and Related Subjects. Trieste, Italy: Sissa Medialab, 2014. http://dx.doi.org/10.22323/1.203.0034.
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Stefanis, N. G., Igor O. Cherednikov, and Alexandros I. Karanikas. "Role and properties of Wilson lines in TMD PDFs." In Light Cone 2010: Relativistic Hadronic and Particle Physics. Trieste, Italy: Sissa Medialab, 2010. http://dx.doi.org/10.22323/1.119.0053.
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Baranov, S. P., A. V. Lipatov, and N. P. Zotov. "TMD PDFs in Drell-Yan lepton pair production at LHC." In DIFFRACTION 2014: International Workshop on Diffraction in High-Energy Physics. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4916001.
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"PDF not yet available in IEEE Xplore." In 2009 Transmission & Distribution Conference & Exposition: Asia and Pacific). IEEE, 2009. http://dx.doi.org/10.1109/td-asia.2009.5357022.
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Murgia, Francesco, Mauro Anselmino, Maria Elena Boglione, Umberto D'Alesio, and Alexei Prokudin. "Unpolarised TMD PDFs and FFs and the role of transverse momentum dependence in azimuthal spin asymmetries." In 23rd International Spin Physics Symposium. Trieste, Italy: Sissa Medialab, 2019. http://dx.doi.org/10.22323/1.346.0036.
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Zhang, Mingjin, Chengyu He, Jing Zhang, Yuxiang Yang, Xiaoqi Peng, and Jie Guo. "SAR-to-Optical Image Translation via Neural Partial Differential Equations." In Thirty-First International Joint Conference on Artificial Intelligence {IJCAI-22}. California: International Joint Conferences on Artificial Intelligence Organization, 2022. http://dx.doi.org/10.24963/ijcai.2022/229.
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Synthetic Aperture Radar (SAR) becomes prevailing in remote sensing while SAR images are challenging to interpret by human visual perception due to the active imaging mechanism and speckle noise. Recent researches on SAR-to-optical image translation provide a promising solution and have attracted increasing attentions, though still suffering from low optical image quality with geometric distortion due to the large domain gap. In this paper, we mitigate this issue from a novel perspective, i.e., neural partial differential equations (PDE). First, based on the efficient numerical scheme for solving PDE, i.e., Taylor Central Difference (TCD), we devise a basic TCD residual block to build the backbone network, which promotes the extraction of useful information in SAR images by aggregating and enhancing features from different levels. Furthermore, inspired by the Perona-Malik Diffusion (PMD), we devise a PMD neural module to implement feature diffusion through layers, aiming at removing the noises in smooth regions while preserving the geometric structures. Assembling them together, we propose a novel SAR-to-Optical image translation network named S2O-NPDE, which delivers optical images with finer structures and less noise while enjoying an explainability advantage from explicit mathematical derivation. Experiments on the popular SEN1-2 dataset show that our model outperforms state-of-the-art methods in terms of both objective metrics and visual quality.
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Kabalci, Idris, Gonul Ozen, Adnan Kurt, Umit Demirbas, and Alphan Sennaroglu. "Spectroscopic properties of Tm3+:TeO 2 -PbF 2 glasses in the near infrared." In Photonics Europe, edited by Alphan Sennaroglu, James G. Fujimoto, and Clifford R. Pollock. SPIE, 2004. http://dx.doi.org/10.1117/12.545996.
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Lelek, Aleksandra Anna. "The role of angular ordering condition in Parton Branching transverse momentum dependent (TMD) PDFs and DY transverse momentum spectrum at LHC." In European Physical Society Conference on High Energy Physics. Trieste, Italy: Sissa Medialab, 2020. http://dx.doi.org/10.22323/1.364.0462.
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Zavada, Petr. "The link between TMDs and PDFs in covariant quark-parton model with orbital motion." In XVIII International Workshop on Deep-Inelastic Scattering and Related Subjects. Trieste, Italy: Sissa Medialab, 2010. http://dx.doi.org/10.22323/1.106.0253.
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Galizia, Antonella, Federica Viti, Andrea Clematis, and Luciano Milanesi. "A Dynamic Parallel Approach to Recognize Tubular Breast Cancer for TMA Image Building." In 2010 18th Euromicro International Conference on Parallel, Distributed and Network-Based Processing (PDP). IEEE, 2010. http://dx.doi.org/10.1109/pdp.2010.75.
Full textReports on the topic "TMD PDF"
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Epel, Bernard L., Roger N. Beachy, A. Katz, G. Kotlinzky, M. Erlanger, A. Yahalom, M. Erlanger, and J. Szecsi. Isolation and Characterization of Plasmodesmata Components by Association with Tobacco Mosaic Virus Movement Proteins Fused with the Green Fluorescent Protein from Aequorea victoria. United States Department of Agriculture, September 1999. http://dx.doi.org/10.32747/1999.7573996.bard.
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The coordination and regulation of growth and development in multicellular organisms is dependent, in part, on the controlled short and long-distance transport of signaling molecule: In plants, symplastic communication is provided by trans-wall co-axial membranous tunnels termed plasmodesmata (Pd). Plant viruses spread cell-to-cell by altering Pd. This movement scenario necessitates a targeting mechanism that delivers the virus to a Pd and a transport mechanism to move the virion or viral nucleic acid through the Pd channel. The identity of host proteins with which MP interacts, the mechanism of the targeting of the MP to the Pd and biochemical information on how Pd are alter are questions which have been dealt with during this BARD project. The research objectives of the two labs were to continue their biochemical, cellular and molecular studies of Pd composition and function by employing infectious modified clones of TMV in which MP is fused with GFP. We examined Pd composition, and studied the intra- and intercellular targeting mechanism of MP during the infection cycle. Most of the goals we set for ourselves were met. The Israeli PI and collaborators (Oparka et al., 1999) demonstrated that Pd permeability is under developmental control, that Pd in sink tissues indiscriminately traffic proteins of sizes of up to 50 kDa and that during the sink to source transition there is a substantial decrease in Pd permeability. It was shown that companion cells in source phloem tissue export proteins which traffic in phloem and which unload in sink tissue and move cell to cell. The TAU group employing MP:GFP as a fluorescence probe for optimized the procedure for Pd isolation. At least two proteins kinases found to be associated with Pd isolated from source leaves of N. benthamiana, one being a calcium dependent protein kinase. A number of proteins were microsequenced and identified. Polyclonal antibodies were generated against proteins in a purified Pd fraction. A T-7 phage display library was created and used to "biopan" for Pd genes using these antibodies. Selected isolates are being sequenced. The TAU group also examined whether the subcellular targeting of MP:GFP was dependent on processes that occurred only in the presence of the virus or whether targeting was a property indigenous to MP. Mutant non-functional movement proteins were also employed to study partial reactions. Subcellular targeting and movement were shown to be properties indigenous to MP and that these processes do not require other viral elements. The data also suggest post-translational modification of MP is required before the MP can move cell to cell. The USA group monitored the development of the infection and local movement of TMV in N. benthamiana, using viral constructs expressing GFP either fused to the MP of TMV or expressing GFP as a free protein. The fusion protein and/or the free GFP were expressed from either the movement protein subgenomic promoter or from the subgenomic promoter of the coat protein. Observations supported the hypothesis that expression from the cp sgp is regulated differently than expression from the mp sgp (Szecsi et al., 1999). Using immunocytochemistry and electron microscopy, it was determined that paired wall-appressed bodies behind the leading edge of the fluorescent ring induced by TMV-(mp)-MP:GFP contain MP:GFP and the viral replicase. These data suggest that viral spread may be a consequence of the replication process. Observation point out that expression of proteins from the mp sgp is temporary regulated, and degradation of the proteins occurs rapidly or more slowly, depending on protein stability. It is suggested that the MP contains an external degradation signal that contributes to rapid degradation of the protein even if expressed from the constitutive cp sgp. Experiments conducted to determine whether the degradation of GFP and MP:GFP was regulated at the protein or RNA level, indicated that regulation was at the protein level. RNA accumulation in infected protoplast was not always in correlation with protein accumulation, indicating that other mechanisms together with RNA production determine the final intensity and stability of the fluorescent proteins.
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Epel, Bernard, and Roger Beachy. Mechanisms of intra- and intercellular targeting and movement of tobacco mosaic virus. United States Department of Agriculture, November 2005. http://dx.doi.org/10.32747/2005.7695874.bard.
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To cause disease, plant viruses must replicate and spread locally and systemically within the host. Cell-to-cell virus spread is mediated by virus-encoded movement proteins (MPs), which modify the structure and function of plasmodesmata (Pd), trans-wall co-axial membranous tunnels that interconnect the cytoplasm of neighboring cells. Tobacco mosaic virus (TMV) employ a single MP for cell- cell spread and for which CP is not required. The PIs, Beachy (USA) and Epel (Israel) and co-workers, developed new tools and approaches for study of the mechanism of spread of TMV that lead to a partial identification and molecular characterization of the cellular machinery involved in the trafficking process. Original research objectives: Based on our data and those of others, we proposed a working model of plant viral spread. Our model stated that MPᵀᴹⱽ, an integral ER membrane protein with its C-terminus exposed to the cytoplasm (Reichel and Beachy, 1998), alters the Pd SEL, causes the Pd cytoplasmic annulus to dilate (Wolf et al., 1989), allowing ER to glide through Pd and that this gliding is cytoskeleton mediated. The model claimed that in absence of MP, the ER in Pd (the desmotubule) is stationary, i.e. does not move through the Pd. Based on this model we designed a series of experiments to test the following questions: -Does MP potentiate ER movement through the Pd? - In the presence of MP, is there communication between adjacent cells via ER lumen? -Does MP potentiate the movement of cytoskeletal elements cell to cell? -Is MP required for cell-to-cell movement of ER membranes between cells in sink tissue? -Is the binding in situ of MP to RNA specific to vRNA sequences or is it nonspecific as measured in vitro? And if specific: -What sequences of RNA are involved in binding to MP? And finally, what host proteins are associated with MP during intracellular targeting to various subcellular targets and what if any post-translational modifications occur to MP, other than phosphorylation (Kawakami et al., 1999)? Major conclusions, solutions and achievements. A new quantitative tool was developed to measure the "coefficient of conductivity" of Pd to cytoplasmic soluble proteins. Employing this tool, we measured changes in Pd conductivity in epidermal cells of sink and source leaves of wild-type and transgenic Nicotiana benthamiana (N. benthamiana) plants expressing MPᵀᴹⱽ incubated both in dark and light and at 16 and 25 ᵒC (Liarzi and Epel, 2005 (appendix 1). To test our model we measured the effect of the presence of MP on cell-to-cell spread of a cytoplasmic fluorescent probe, of two ER intrinsic membrane protein-probes and two ER lumen protein-probes fused to GFP. The effect of a mutant virus that is incapable of cell-to-cell spread on the spread of these probes was also determined. Our data shows that MP reduces SEL for cytoplasmic molecules, dilates the desmotubule allowing cell-cell diffusion of proteins via the desmotubule lumen and reduces the rate of spread of the ER membrane probes. Replicase was shown to enhance cell-cell spread. The data are not in support of the proposed model and have led us to propose a new model for virus cell-cell spread: this model proposes that MP, an integral ER membrane protein, forms a MP:vRNAER complex and that this ER-membrane complex diffuses in the lipid milieu of the ER into the desmotubule (the ER within the Pd), and spreads cell to cell by simple diffusion in the ER/desmotubule membrane; the driving force for spread is the chemical potential gradient between an infected cell and contingent non-infected neighbors. Our data also suggests that the virus replicase has a function in altering the Pd conductivity. Transgenic plant lines that express the MP gene of the Cg tobamovirus fused to YFP under the control the ecdysone receptor and methoxyfenocide ligand were generated by the Beachy group and the expression pattern and the timing and targeting patterns were determined. A vector expressing this MPs was also developed for use by the Epel lab . The transgenic lines are being used to identify and isolate host genes that are required for cell-to-cell movement of TMV/tobamoviruses. This line is now being grown and to be employed in proteomic studies which will commence November 2005. T-DNA insertion mutagenesis is being developed to identify and isolate host genes required for cell-to-cell movement of TMV.
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Plummer, J. R., D. M. Immel, M. G. Serrato, M. J. Dalmaso, and D. J. Shull. GrayQbTM Single-Faced Version 2 (SF2) Hanford Plutonium Reclamation Facility (PRF) deployment report. Office of Scientific and Technical Information (OSTI), November 2015. http://dx.doi.org/10.2172/1228058.
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Zheng, Jiaxi, and Haihua Yang. Clinical Benefits of Immune Checkpoint Inhibitors and Predictive Value of Tumor Mutation Burden in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0008.
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Review question / Objective: Is immunotherapy associated with beneficial clinical outcomes for hepatocellular carcinoma (HCC) and how can combination immunotherapy be deployed to produce the best benefit? Is tumor mutation burden (TMB) a predictive biomarker for immune‐checkpoint inhibitors? Condition being studied: To this date, about 50 single-arm clinical trials and several randomized control trials (RCTs) presented final or interim results of investigations on the efficacy of PD-1/PD-L1 inhibitors for advanced HCC. In the CheckMate 459, IMbrave 050, and ORIENT-32, immunotherapies were found to significantly improve progression-free survival (PFS) and overall survival (OS) compared with sorafenib (a tyrosine-kinase inhibitor, as standard systemic treatment) in patients with advanced hepatocellular carcinoma. However, these clinical trials were different on clinical phases, sample size, and response evaluation criteria, and inconsistent clinical outcomes were shown in several trials.
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Ni, Ni. Structural/magnetic phase transitions and superconductivity in Ba(Fe1-xTMx)2As2 (TM=Co, Ni, Cu, Co/Cu, Rh and Pd) single crystals. Office of Scientific and Technical Information (OSTI), January 2009. http://dx.doi.org/10.2172/985311.
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