Academic literature on the topic 'TLWs'
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Journal articles on the topic "TLWs"
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Suzuki, Haruka, Junzo Hamanishi, Meng Qin, Masayo Ukita, Akihiko Ueda, Shunsuke Kawahara, Koji Yamanoi, et al. "Abstract 6109: Clonal relationship of B cells between tertiary lymphoid structures (TLSs) and tumor infiltrating lymphocytes (TILs) in advanced endometrial cancer." Cancer Research 82, no. 12_Supplement (June 15, 2022): 6109. http://dx.doi.org/10.1158/1538-7445.am2022-6109.
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Abstract Objective: Tertiary lymphoid structures (TLSs) are known to be a marker of peripheral inflammation. While high densities of TLSs were reported to be associated with longer patient survival in several cancer types, there is no direct evidence where B cells in TLSs(TLBs) are derived from and whether these clones are consistent with tumor infiltrating B cells (TIBs), in endometrial cancer. Methods: We analyzed the pathological distribution of TLSs and TIBs in human endometrial cancer samples using immunohistochemistry of a series of B cell markers and evaluated the relationship with patients’ clinical outcomes. Additionally, we micro-dissected six pairs of tumor nests and their neighbor TLSs and analyzed the clonal consistency between TLBs and TIBs using the sequencing of complementarity-determining region (CDR) of B cell receptor (BCR). Results: In 104 patients with endometrial cancer, TLSs were detected in 81 patients (78%), and the absence of TLS was related to worse progression-free survival (PFS) (HR, 0.15, P <0.01). Among TLS-detected cases, the high number of TIBs was significantly associated with better PFS (P<0.05). BCR analyses in the six patients found that three patients with advanced stage had a unique B cell clones in common between TLBs and TIBs, while the other three patients with early stage did not have any common B cell clones. The frequency of common B cell clones in the former three patients were 10.3% (5250/51146 reads), 9.7% (1873/19369 reads) and 3.0% (1034/34618 reads). Conclusion: TLSs and TIBs are associated with better prognosis in endometrial cancer. Common B cell clones were found in the advanced stage cases, suggesting that B cells may have gradually acquired immunospecificity in TLSs. Citation Format: Haruka Suzuki, Junzo Hamanishi, Meng Qin, Masayo Ukita, Akihiko Ueda, Shunsuke Kawahara, Koji Yamanoi, Taito Miyamoto, Shiro Takamatsu, Mana Taki, Yoko Hosoe, Takashi Kobayashi, Ken Yamaguchi, Masaki Mandai. Clonal relationship of B cells between tertiary lymphoid structures (TLSs) and tumor infiltrating lymphocytes (TILs) in advanced endometrial cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6109.
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Masuda, Tsukasa, Nobuyuki Tanaka, Kimiharu Takamatsu, Kyohei Hakozaki, Ryohei Takahashi, Tadatsugu Anno, Ryohei Kufukihara, et al. "Unique characteristics of tertiary lymphoid structures in kidney clear cell carcinoma: prognostic outcome and comparison with bladder cancer." Journal for ImmunoTherapy of Cancer 10, no. 3 (March 2022): e003883. http://dx.doi.org/10.1136/jitc-2021-003883.
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BackgroundThe aims of this study were (1) to clarify the impact of tertiary lymphoid structure (TLS) status on the outcome and immunogenomic profile of human clear cell renal cell carcinoma (ccRCC) and (2) to determine phenotypic differences in TLSs between different types of genitourinary cancer, that is, urinary ccRCC and bladder cancer.MethodsWe performed a quantitative immunohistological analysis of ccRCC tissue microarrays and conducted integrated genome mutation analysis by next-generation sequencing and methylation array analysis. Since the tumor immune microenvironment of ccRCC often differs from that of other cancer types, we analyzed the phenotypic differences in TLSs between ccRCC and in-house bladder cancer specimens.ResultsVarying distribution patterns of TLSs were observed throughout ccRCC tumors, revealing that the presence of TLSs was related to poor prognosis. An analysis of genomic alterations based on TLS status in ccRCC revealed that alterations in the PI3K-mTOR pathway were highly prevalent in TLS-positive tumors. DNA methylation profiling also revealed distinct differences in methylation signatures among ccRCC samples with different TLS statuses. However, the TLS characteristics of ccRCC and bladder cancer markedly differed: TLSs had the exact opposite prognostic impact on bladder cancer as on ccRCC. The maturity and spatial distribution of TLSs were significantly different between the two cancer types; TLSs were more mature with follicle-like germinal center organization and likely to be observed inside the tumor in bladder cancer. Labeling for CD8, FOXP3, PD-1, and PD-L1 showed marked differences in the diversity of the immune microenvironment surrounding TLSs. The proportions of CD8-, FOXP3-, and PD-L1-positive cells were significantly higher in TLSs in bladder cancer than in TLSs in ccRCC; rather the proportion of PD-1-positive cells was significantly higher in TLSs in ccRCC than in TLSs in bladder cancer.ConclusionThe immunobiology of ccRCC is unique, and various cancerous phenomena conflict with that seen in other cancer types; therefore, comparing the TLS characteristics between ccRCC and bladder cancer may help reveal differences in the prognostic impact, maturity and spatial distribution of TLSs and in the immune environment surrounding TLSs between the two cancers.
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Li, Zhe, Yuming Jiang, Bailiang Li, Zhen Han, Jeanne Shen, Yong Xia, and Ruijiang Li. "Development and Validation of a Machine Learning Model for Detection and Classification of Tertiary Lymphoid Structures in Gastrointestinal Cancers." JAMA Network Open 6, no. 1 (January 24, 2023): e2252553. http://dx.doi.org/10.1001/jamanetworkopen.2022.52553.
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ImportanceTertiary lymphoid structures (TLSs) are associated with a favorable prognosis and improved response to cancer immunotherapy. The current approach for evaluation of TLSs is limited by interobserver variability and high complexity and cost of specialized imaging techniques.ObjectiveTo develop a machine learning model for automated and quantitative evaluation of TLSs based on routine histopathology images.Design, Setting, and ParticipantsIn this multicenter, international diagnostic/prognostic study, an interpretable machine learning model was developed and validated for automated detection, enumeration, and classification of TLSs in hematoxylin-eosin–stained images. A quantitative scoring system for TLSs was proposed, and its association with survival was investigated in patients with 1 of 6 types of gastrointestinal cancers. Data analysis was performed between June 2021 and March 2022.Main Outcomes and MeasuresThe diagnostic accuracy for classification of TLSs into 3 maturation states and the association of TLS score with survival were investigated.ResultsA total of 1924 patients with gastrointestinal cancer from 7 independent cohorts (median [IQR] age ranging from 57 [49-64] years to 68 [58-77] years; proportion by sex ranging from 214 of 409 patients who were male [52.3%] to 134 of 155 patients who were male [86.5%]). The machine learning model achieved high accuracies for detecting and classifying TLSs into 3 states (TLS1: 97.7%; 95% CI, 96.4%-99.0%; TLS2: 96.3%; 95% CI, 94.6%-98.0%; TLS3: 95.7%; 95% CI, 93.9%-97.5%). TLSs were detected in 62 of 155 esophageal cancers (40.0%) and up to 267 of 353 gastric cancers (75.6%). Across 6 cancer types, patients were stratified into 3 risk groups (higher and lower TLS score and no TLS) and survival outcomes compared between groups: higher vs lower TLS score (hazard ratio [HR]; 0.27; 95% CI, 0.18-0.41; P &lt; .001) and lower TLS score vs no TLSs (HR, 0.65; 95% CI, 0.56-0.76; P &lt; .001). TLS score remained an independent prognostic factor associated with survival after adjusting for clinicopathologic variables and tumor-infiltrating lymphocytes (eg, for colon cancer: HR, 0.11; 95% CI, 0.02-0.47; P = .003).Conclusions and RelevanceIn this study, an interpretable machine learning model was developed that may allow automated and accurate detection of TLSs on routine tissue slide. This model is complementary to the cancer staging system for risk stratification in gastrointestinal cancers.
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Baneh, Hasan, Javad Ahmadpanah, and Yahya Mohammadi. "Genetic analysis of reproductive characteristics in Iran-Black sheep." Acta Scientiarum. Animal Sciences 42 (January 30, 2020): e47380. http://dx.doi.org/10.4025/actascianimsci.v42i1.47380.
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This study was conducted to estimate genetic parameters and trends for reproduction traits using data collected at the breeding station of Iran-Black sheep during 1980 to 2004. The traits included in the analyses were litter size at birth (LSB) and weaning (LSW) and litter mean weight per lamb born (LMWLB) and weaned (LMWLW) as basic traits, and total litter weight at birth (TLWB) and weaning (TLWW) as composite traits. Direct heritability estimates for LSB, TLWB, LMWLB, LSW, TLWW and LMWLW were 0.11, 0.07, 0.33, 0.08, 0.09 and 0.11, respectively. The permanent environmental effects had significant impact on all traits and ranged from 0.05 to 0.16. Effect of service sire was highly significant (p < 0.01) for all traits except LMWLW. Estimates of genetic correlations ranged from -0.76 (LSB-LMWLB) to 0.98 (LSB-LSW). Phenotypic and environmental correlations were generally lower than those of genetic correlations. Environmental correlations ranged from -0.55 (LSW-LMWLW) to 0.99 (LSB-LSW). Also, the estimated correlation for the effect of service sire ranged from -0.77 (LMWLB-TLWW) to 0.96 (LSB-LSW and LSB-TLWW). The results suggest that selection based on TLWB could be more effective than the other traits to enhance reproductive performance in Iran-Black ewes.
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Zou, Ji’an, Yingzhe Zhang, Yue Zeng, Yurong Peng, Junqi Liu, Chaoyue Xiao, and Fang Wu. "Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy." Cancers 14, no. 23 (December 2, 2022): 5968. http://dx.doi.org/10.3390/cancers14235968.
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A tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs). For cancer patients, evaluation of the immune microenvironment has a predictive effect on tumor biological behavior, treatment methods, and prognosis. As a result, TLSs have begun to attract the attention of researchers as a new potential biomarker. However, the composition and mechanisms of TLSs are still unclear, and clinical detection methods are still being explored. Although some meaningful results have been obtained in clinical trials, there is still a long way to go before such methods can be applied in clinical practice. However, we believe that with the continuous progress of basic research and clinical trials, TLS detection and related treatment can benefit more and more patients. In this review, we generalize the definition and composition of TLSs, summarize clinical trials involving TLSs according to treatment methods, and describe possible methods of inducing TLS formation.
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Eteqadi, Bahareh, Navid Ghavi Hossein-Zadeh, and Abdol Ahad Shadparvar. "Genetic Analysis of Basic and Composite Reproduction Traits in Guilan Sheep." Annals of Animal Science 17, no. 1 (January 1, 2017): 105–16. http://dx.doi.org/10.1515/aoas-2016-0016.
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Abstract The objective of the present study was to estimate genetic parameters for reproductive traits in Guilan sheep. Data were comprised of 14,534 records of lambs from 136 sires and 2,021 dams which were collected during 1994 to 2011 by the Agriculture Organization of Guilan Province in the north of Iran. The basic reproductive traits were litter size at birth (LSB), litter size at weaning (LSW), litter mean weight per lamb born (LMWLB), and litter mean weight per lamb weaned (LMWLW). The composite reproductive traits were total litter weight at birth per ewe lambing (TLWB) and total litter weight at weaning per ewe lambing (TLWW). The general linear model procedure of SAS was used for determining the fixed effects which had significant effect on the traits under study. The flock-year-season of lambing had significant effect on studied traits (P<0.01). The genetic parameters were estimated with repeatability animal model using restricted maximum likelihood (REML) procedure of the Wombat program. Direct heritability estimates were 0.00, 0.00, 0.01, 0.01, and 0.03 for LSB, LSW, LMWLW, TLWB, and TLWW, respectively, and corresponding repeatabilities were 0.2, 0.00006, 0.01, 0.972 and 0.034, respectively. Genetic correlation estimates between traits ranged from -0.99 for LSB-LSW to 0.99 for LMWLW-TLWW. Phenotypic correlations ranged from -0.09 for LSB-TLWB to 0.98 for LMWLW-TLWW and environmental correlations ranged from -0.03 for LSW-TLWW to 0.98 for LMWLW-TLWW. The results showed that strong positive genetic correlations of LMWLB and LMWLW with other traits may improve meat production efficiency in Guilan sheep. The low estimates of heritability and repeatability obtained for ewe productivity traits indicate that selection based on the ewe’s own performance may result in slow genetic improvement.
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Li, Jianhui, Ye Nie, Weili Jia, Wenlong Wu, Wenjie Song, and Yongxiang Li. "Effect of Tertiary Lymphoid Structures on Prognosis of Patients with Hepatocellular Carcinoma and Preliminary Exploration of Its Formation Mechanism." Cancers 14, no. 20 (October 21, 2022): 5157. http://dx.doi.org/10.3390/cancers14205157.
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Background: Tertiary lymphoid structures (TLSs) are formed by the aggregation of tumour-infiltrating lymphocytes (TILs), which is driven by chemokines or cytokines in the tumour microenvironment. Studies have shown that TLSs are associated with good prognosis in patients with various solid tumours and can improve patient responses to immunotherapy. However, the role of TLSs in hepatocellular carcinoma (HCC) remains controversial, and the underlying molecular mechanism is unclear. Methods: According to haematoxylin-eosin (HE) staining results, HCC patients in Xijing Hospital data and TCGA data were divided into TLS+ and TLS- groups, and Kaplan–Meier (KM) analysis was performed to assess overall survival (OS) and recurrence-free survival (RFS). Immunofluorescence (IF) and immunohistochemistry (IHC) were used to identify TILs in the TLS+ group. Lymphocyte-specific protein tyrosine kinase (LCK), a molecule involved in TLS formation, was explored in LinkedOmics. TILs were divided into two groups by drawing receiver operating characteristic (ROC) curves to calculate cut-off values. Spearman correlation analysis was used to calculate the correlation between LCK and TILs, and the molecular pathways by which LCK regulates immunotherapy were clarified through enrichment analysis. The half-maximal inhibitory concentration (IC50) distribution of sorafenib was observed in groups that varied in LCK expression. Results: According to the HE results, 61 cases in the Xijing Hospital cohort and 195 cases in the TCGA cohort had TLSs, while 89 cases and 136 cases did not. The KM results showed that TLSs had no effect on the OS of HCC patients but significantly affected RFS. The IF/IHC results showed that higher TIL numbers in TLSs were correlated with better prognosis in HCC patients. Spearman correlation analysis showed that LCK expression was positively correlated with TIL numbers. Enrichment analysis showed that upregulation of LCK expression mainly regulated the cytokine signalling pathway, the chemokine signalling pathway and T-cell activation. The IC50 scores of sorafenib in HCC patients with high LCK expression were lower, and the sensitivity was higher. Conclusion: TLSs mainly affected the early RFS of HCC patients but had no effect on OS. The high expression of the TLS formation-related gene LCK can increase the sensitivity of HCC patients to ICIs.
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Pikarsky, Eli. "Abstract IA02: The good and the bad sides of tertiary lymphoid structures in liver cancer." Clinical Cancer Research 28, no. 17_Supplement (September 1, 2022): IA02. http://dx.doi.org/10.1158/1557-3265.liverca22-ia02.
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Abstract Tertiary lymphoid structures (TLSs) are formed in chronically inflamed tissues in response to stress. They form an in situ source for adaptive immune responses, and are considered the frontal command posts of the adaptive immune system. In cancer, they were first recognized to be associated with a good prognosis (e.g. in colorectal cancer and melanoma). Later on, we and others noted that in some cancers their presence can be associated with worse prognosis. In particular, we showed that they can form microniches in which tumor cells can proliferate, depending on cues that are derived from TLS residing cells. Recently, several studies showed that TLSs are important in responding to immune checkpoint inhibitors, indicating that T cell exhaustion could play a role in TLS dysfunction. We hypothesized, that similar to single cells, TLSs can also become dysfunctional, explaining why in particular cases they can be associated with a bad outcome in cancer. Using a mouse model of TLS dependent liver cancer we find that T cell exhaustion is prevalent in pro-tumorigenic TLSs in the liver, and dissect the cell types that are responsible for this immunopathologic state. Our studies of human tissues are in line with the notion that TLS dysfunction correlates with T cell exhaustion in TLSs. Citation Format: Eli Pikarsky. The good and the bad sides of tertiary lymphoid structures in liver cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in the Pathogenesis and Molecular Therapies of Liver Cancer; 2022 May 5-8; Boston, MA. Philadelphia (PA): AACR; Clin Cancer Res 2022;28(17_Suppl):Abstract nr IA02.
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Zhang, Fa-Peng, Ke Zhu, Tai-Feng Zhu, Chao-Qun Liu, Hong-Hua Zhang, Lei-Bo Xu, Gang Xiao, and Chao Liu. "Intra-Tumoral Secondary Follicle-like Tertiary Lymphoid Structures Are Associated with a Superior Prognosis of Overall Survival of Perihilar Cholangiocarcinoma." Cancers 14, no. 24 (December 12, 2022): 6107. http://dx.doi.org/10.3390/cancers14246107.
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Ectopic lymphoid structures termed tertiary lymphoid structures (TLSs) have an immunomodulatory function and positively affect prognosis in certain cancers. However, their clinical relevance and prognostic utility in perihilar cholangiocarcinoma (pCCA) are unknown. Therefore, determining the involvement and prognostic utility of TLSs in pCCA is the aim of this study. Ninety-three patients with surgically resected pCCA were included retrospectively. Hematoxylin and eosin and immunohistochemical staining identified and classified the TLSs, and multiplex immunofluorescence determined the TLS composition in the pCCA sample. The correlations between clinical features and TLSs were analyzed using either Fisher’s exact test or the Chi-squared test. Recurrence-free survival (RFS) and overall survival (OS) correlations with TLSs were analyzed using Cox regression and Kaplan–Meier analyses. We identified TLSs in 86% of patients with pCCA, including lymphoid aggregates (6.45%), primary (13.98%) and secondary follicles (65.59%). Patients with intra-tumoral secondary follicle-like TLSs (S-TLSs) had better OS (p = 0.003) and RFS (p = 0.0313). The multivariate analysis identified the presence of S-TLSs as a good independent prognostic indicator for OS but not for RFS. Interestingly, the presence of S-TLS only indicated better 5-year OS in 54 patients without lymph node metastasis (LNM−, p = 0.0232) but not in the 39 patients with lymph node metastasis (LNM+, p = 0.1244). Intra-tumoral S-TLSs predicted longer OS in patients with surgically resected pCCA, suggesting intra-tumoral S-TLSs’ contribution to effective antitumor immunity and that S-TLSs hold promise for diagnostic and therapeutic development in pCCA.
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Nundel, Kerstin (Kiefer), Stephanie Moses, Jillian M. Richmond, Carla V. Rothlin, and Ann Marshak-Rothstein. "TLR9 dependent regulation of AXL expression impacts migration of autoreactive B cells." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 218.15. http://dx.doi.org/10.4049/jimmunol.204.supp.218.15.
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Abstract Migration of autoreactive B cells to target tissues and the formation of tertiary lymphoid structures (TLS) is an important step in end-organ damage in autoimmune disease. TLSs are thought to be the main site of autoantibody production by autoreactive B cells, leading to immune complex formation and deposition in the affected organ. The formation of TLS was reported to be dependent on B cells as well as chemokines like CXCL13. Hence it is of importance to understand the migratory behavior of autoreactive B cells to these sites and how it is regulated. The receptor tyrosine kinase AXL was shown to play a role in the migration of cancer cells and expression of AXL in cancer cells is usually associated with worse prognoses. We found that AXL expression on B cells is highly induced by crosslinking of the B cell receptor (BCR) and not by TLR ligation as in dendritic cells and macrophages. Intriguingly, co-engagement of TLR9 together with the BCR inhibits AXL upregulation. This is unique to TLR9 and does not occur following co-engagement with other TLRs. Furthermore, we have found that AXL deficient B cells have a diminished potential to migrate in response to the B cell chemokine CXCL13. Also, in the pristane induced model of SLE, mice with AXL deficient B cells have lower numbers of TLS in the peritoneum compared to mice with AXL sufficient B cells, further supporting a role of AXL in the migration of B cells. Our data suggests that TLR9 plays an important role in suppressing AXL expression and the concurrent inhibition of B cell migration to TLS. Our studies have the potential to identify a novel and pharmacologically tractable mechanism for restricting the migration of autoreactive B cells and ensuing tissue damage.
Dissertations / Theses on the topic "TLWs"
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Klasila, A. (Aleksi). "TryTLS:testing TLS libraries." Bachelor's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201712203359.
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Encryption is a fundamental building block in protecting our privacy and safety of our society, unfortunately we may fail to use it properly. TLS (Transport Layer Security) has an important part in encrypting the connections on the Internet today. SSL (Socket Layer Security) is the deprecated and dangerous version of TLS. SSL should not be used anymore. There are many protocols developed that use TLS. For example: HTTPS (Hypertext Transfer Protocol Secure), FTPS (File Transfer Protocol with support for TLS) and IMAP (Internet Message Access Protocol). All the protocols using TLS have also got many different implementations in different programming languages and libraries. This thesis researches the tools used to test how different (client-) libraries implement TLS. This thesis also researches the known TLS/SSL vulnerabilities. In this thesis a backed for TLS testing purposes is implementedSalaus on perusrakenneosa yksityisyyden ja turvallisuuden suojaamisessa yhteiskunnassamme, valitettavasti saatamme suoriutua siinä huonosti. TLS:llä (Transport Layer Security) on nykyisin tärkeä osa Internet-liikenteen salaamisessa. SSL (Socket Layer Security) on TLS:n vanhentunut ja vaarallinen edeltäjä. SSL:ää ei pitäisi käyttää enään nykyisin. On olemassa monia protokollia, kuten HTTPS (Hypertext Transfer Protocol Secure), FTPS (File Transfer Protocol with support for TLS) ja IMAP (Internet Message Access Protocol), jotka käyttävät TLS:ää. Lisäksi, kaikilla TLS:ää käyttävillä protokollilla on useita toteutuksia eri ohjelmointikielillä ja kirjastoilla. Tässä työssä tutkitaan kehitettyjä työkaluja TLS-kirjastojen testaamiseen. Tässä työssä tutkitaan myös tunnettuja TLS/SSL-haavoittuvuuksia. Tässä työssä rakennetaan lisäksi järjestelmä TLS:n testaamista varten
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McLeary, Alwyn. "Dynamic response of TLPs during tether installation." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394952.
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Li, Jiatong. "TLS Library for Isolated Enclaves : Optimizing the performance of TLS libraries for SGX." Thesis, KTH, Kommunikationssystem, CoS, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-241245.
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Nowadays cloud computing systems handle large amounts of data and process this data across different systems. It is essential to considering data security vulnerabilities and data protection. One means of decreasing security vulnerabilities is to partition the code into distinct modules and then isolate the execution of the code together with its data. Intel’s Software Guard Extension (SGX) provides security critical code isolation in an enclave. By isolating the code’s execution from an untrusted zone (an unprotected user platform), code integrity and confidentiality are ensured. Transport Layer Security (TLS) is responsible for providing integrity and confidentiality for communication between two entities. Several TLS libraries support cryptographic functions both for an untrusted zone and an enclave. Different TLS libraries have different performance when used with Intel’s SGX. It is desirable to use the best performance TLS library for specific cryptographic functions. This thesis describes a performance evaluation several popular TLS libraries performance on Intel SGX. Using the evaluation results and combining several different TLS libraries together, the thesis proposes a new solution to improve the performance of TLS libraries on Intel SGX. The performance is best when invoking the best specific TLS library based upon the data size – as there is a crossover in performance between the two best libraries. This solution also maintains the versatility of the existing cryptographic functions.Numera hanterar molnberäkningssystem stora mängder data och bearbetar dessa data över olika system. Det är viktigt att ta itu med datasäkerhetsproblem och dataskydd. Ett sätt att minska säkerhetsproblem är att partitionera koden i olika moduler och sedan isolera kodens exekvering tillsammans med dess data. Intel’s Software Guard Extension (SGX) tillhandahåller säkerhetskritisk kodisolering i en enklav. Genom att isolera kodens körning från en otillförlitlig zon (en oskyddad användarplattform) säkerställs kodintegritet och sekretess. Transport Layer Security (TLS) ansvarar för att ge integritet och konfidentialitet för kommunikation mellan två enheter. Flera TLS-bibliotek stödjer kryptografiska funktioner både för en osäker zon och en enklav. Olika TLS-bibliotek har olika prestanda när de används med Intel’s SGX. Det är önskvärt att använda TLS-bibliotekets bästa prestanda för specifika kryptografiska funktioner. Denna avhandling beskriver en prestationsutvärdering av flera populära TLS-bibliotekens prestanda på Intel SGX. Genom att använda utvärderingsresultaten och kombinera flera olika TLS-bibliotek tillsammans, presenterar avhandlingen en ny design och lösning för att förbättra prestanda för TLS-bibliotek på Intel SGX. Den resulterande prestanda åberopar TLS-bibliotekets bästa prestanda inom en viss datastorlek samtidigt som krypteringsfunktionerna är mångsidiga.
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Moore, Mark. "ST2 & TLRs : coordination of chemokine-driven immunity." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/830/.
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Abstract The detection of pathogen-associated molecules by Toll-like receptors (TLRs) is instrumental to the induction and regulation of an inflammatory response. However, prolonged or inappropriate stimulation of TLRs is associated with disease. A family of molecules coded for by the ST2 gene have been implicated as negative regulators of TLR4-signalling in murine cells. Here, the existence and potential role of these ST2 molecules in human macrophages has been investigated. Following the discovery of IL-33 as a ligand for ST2, the effect of this ligand on human macrophages was explored. We found elevated levels of the soluble form of ST2 (sST2) in the synovial fluid (SF) of patients with inflammatory forms of arthritis compared to amount in SF from people diagnosed with a less inflammatory form of arthritis. First confirming that human macrophages express the trans-membrane version of ST2 known as ST2L, we showed these cells respond to a recombinant form of the IL-33 ligand by inducing the release of inflammatory chemokines but not cytokines. The migration of inflammatory cells into inflamed tissue is influenced by their recognition of chemokines. The expression of receptors for these chemokines, the so called chemokine receptors (CCRs) is therefore pivotal in the recruitment of leukocytes into inflamed tissues. The regulation of the CCRs by TLR agonists has recently emerged as a fundamental axis in regulating inflammation. Whilst the local administration of TLR-ligands paradoxically increases leukocyte recruitment to sites of inflammation (thereby exacerbating it), in contrast, low, systemic doses of TLR-ligand have been found to be anti-inflammatory. The work of the second part of this thesis has reinforced the concept that the attenuation of inflammation by systemically-delivered TLR-agonists is due to a reduced migration of leukocytes into sites of inflammation. By adoptively transferring an equal number of discretely labelled cells from WT- and TLR2-KO- mice into WT mice with an existing inflammation, we were able to show that systemic administration of a TLR2 agonist caused a reduction in the number of transferred WT- but not TLR2-KO- cells migrating into the site inflammation. Consistent with this, more WT- than TLR2-KO-cells were detected in the lymph nodes of TLR2 agonist-, but not control- treated mice. For the first time the anti-inflammatory effect of TLR ligands has been shown to work in a cell autonomous manner, i.e. the migratory cells need to detect the TLR ligand directly for their migratory capacity to be diminished.
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Kassem, Ali. "Toll-like receptors (TLRs) and inflammatory bone modeling." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110296.
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Patients with inflammatory or infectious conditions such as periodontitis, peri-implantitis, osteomyelitis, rheumatoid arthritis, septic arthritis and loosened joint prosthesis display varying severity of destruction in the adjacent bone tissue. Bone loss in inflammatory diseases is considered a consequence of cytokine induced RANKL and subsequent enhanced osteoclast formation. Hence, osteotropic cytokines and their receptors have been suggested to be important for the pathogenesis of inflammation-induced osteolysis. It is, here, suggested that bacterial components, so called “pathogen associated molecular patterns=PAMPs”, may also be involved. Varieties of cells express receptors for PAMPs, including Toll-like receptors (TLRs) which are the first line of defence in the innate immune system. LPS (lipopolysaccharide), fimbria and lipoproteins from pathogenic bacteria such as P. gingivalis, S. aureus are ligands for TLR2 and flagellin from pathogenic flagellated bacteria like S. typhimurium is a ligand for TLR5. Since the susceptibility to, or the severity of inflammation-associated bone diseases are likely related to differences in the tissue response, and the mechanisms by which PAMPs interact with bone cells are not fully understood, we aimed to elucidate the importance of different TLRs for inflammation induced bone loss by conducting in vitro and in vivo investigations. Activation of TLR2 and TLR5 in organ cultured mouse parietal bones increased bone resorption in a time- and concentration-dependent manner by a process inhibited by OPG and bisphosphonate, showing the crucial role of RANKL-induced osteoclast formation. In addition, the number of osteoclasts, expression of osteoclastic genes and osteoclastogenic transcription factors were increased. In the bones and in osteoblasts isolated from the bones, TLR2 agonists increased the expression of RANKL without affecting OPG, while TLR5 activation resulted in enhanced RANKL and decreased OPG. Activation of both TLR2 and TLR5 stimulated the expression in both bones and osteoblasts of prostaglandins and pro-inflammatory cytokines, known to stimulate RANKL. By blocking the cytokines and prostaglandin, we showed that TLR2 and TLR5 induced bone resorption and RANKL expression are independent of these molecules. Activation of TLR2, but not TLR5, in mouse bone marrow macrophage cultures inhibited RANKL-induced osteoclast formation, an effect not observed in committed pre-osteoclasts. Local administration in vivo of TLR2 and TLR5 agonists on the top of mouse skull bones enhanced local and systemic osteoclast formation and bone resorption. Using knockout mice, we showed that the effects by LPS from P. gingivalis (used as TLR2 agonist) and flagellins (used as TLR5 agonists) are explicit for TLR2 and TLR5 ex vivo and in vivo, respectively. These data show that stimulation of TLR2 and TLR5 results in bone resorption in vitro and in vivo mediated by increased RANKL in osteoblasts and thus may be one mechanism for developing inflammatory bone loss. Interestingly, histological analyses of skull bones of mice treated locally with TLR2 and TLR5 agonists revealed that the bones not only reacted with locally increased osteoclastogenesis (osteoclast formation), but also with locally increased new bone formation. This was observed on both periosteal and endosteal sides of the bones, as well as in the bone marrow compartment. The formation of new bone was seen close to osteoclasts in some parts, but also in other areas, distant from these cells. The response was associated with active, cuboidal osteoblasts, extensive cell proliferation and increased expression of genes coding for bone matrix proteins and osteoblastic transcription factors. In conclusion, activation of TLR2 and TLR5 in osteoblasts results in bone loss associated with enhanced osteoclast formation and bone resorption, as well as with increased osteoblast differentiation and new bone formation, indicating that inflammation causes bone modeling. The data provide an explanation why LPS from P. gingivalis and flagellin from flagella-expressing bacteria can stimulate bone loss. Since TLR2 and TLR5 can be activated not only by bacterial components, but also by endogenous ligands produced in inflammatory processes, the data also contribute to the understanding of inflammation induced bone loss in autoimmune diseases. Hopefully, these findings will contribute to the development of treatment strategies for inflammation induced bone loss.
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Vinje, Eivind. "Educational implementation of SSL/TLS." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for datateknikk og informasjonsvitenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-13834.
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Levillain, Olivier. "Une étude de l’écosystème TLS." Thesis, Evry, Institut national des télécommunications, 2016. http://www.theses.fr/2016TELE0014/document.
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SSL/TLS, un protocole de sécurité datant de 1995, est devenu aujourd'hui une brique essentielle pour la sécurité des communications, depuis les sites de commerce en ligne ou les réseaux sociaux jusqu'aux réseaux privés virtuels (VPN), en passant par la protection des protocoles de messagerie électronique, et de nombreux autres protocoles. Ces dernières années, SSL/TLS a été l'objet de toutes les attentions, menant à la découverte de nombreuses failles de sécurité et à des améliorations du protocole. Dans cette thèse, nous commençons par explorer l'écosystème SSL/TLS sur Internet en énumérant les serveurs HTTPS sur l'espace IPv4; nous proposons pour cela des méthodologies de collecte et d'analyse permettant d'obtenir des résultats reproductibles et comparables entre différentes campagnes de mesure. Au-delà de ces observations, nous nous sommes intéressés en détail à deux aspects essentiels de la sécurité TLS: comment parer les attaques sur le Record Protocol, et comment implémenter des parsers sûrs et efficaces. Finalement, en se basant sur les nombreuses failles d'implémentation qui ont affecté presque toutes les piles TLS ces dernières années, nous tirons quelques enseignements concernant les difficultés liées à l'écriture d'une bibliothèque TLS de confianceSSL/TLS, a 20-year old security protocol, has become a major component securing network communications, from HTTPS e-commerce and social network sites to Virtual Private Networks, from e-mail protocols to virtually every possible protocol. In the recent years, SSL/TLS has received a lot of attentions, leading to the discovery of many security vulnerabilities, and to protocol improvements. In this thesis, we first explore the SSL/TLS ecosystem at large using IPv4 HTTPS scans, while proposing collection and analysis methodologies to obtain reproducible and comparable results across different measurement campaigns. Beyond these observations, we focused on two key aspects of TLS security: how to mitigate Record Protocol attacks, and how to write safe and efficient parsers. Finally, building on the numerous implementation flaws in almost all TLS stacks in the last years, we propose some thoughts about the challenges in writing a secure TLS library
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Cavalieri, Tássio Antonio. "Emprego do MCNP no estudo dos TLDs 600 e 700 visando a implementação da caracterização do feixe de irradiação na instalação de BNCT do IEA-R1." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85133/tde-19112013-135350/.
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A Terapia de Captura de Nêutron por Boro (BNCT) é uma terapia de combate ao câncer bimodal, na qual a energia útil da terapia vem da reação nuclear que ocorre pelo Boro quando irradiado com nêutrons térmicos. No IPEN há uma instalação de pesquisas em BNCT, na qual o feixe de radiação contendo nêutrons é proveniente do reator IEA-R1. Como condição desta terapia é necessário realizar a dosimetria do feixe de radiação, que atualmente é feito com o uso de folhas de ativação, para cálculo do fluxo de nêutrons, e do dosímetro TLD 400, para estimativa da dose gama. Para campos mistos de nêutrons e gamas, a Comissão Internacional de Unidades e Medidas (ICRU) recomenda o uso de dosímetros com sensibilidades distintas para as componentes do feixe, como o caso do par TLD 600 e TLD 700 que apresentam sensibilidades distintas a nêutrons térmicos, devido à diferente quantidade do isótopo 6Li em sua composição, o qual apresenta uma alta seção de choque para nêutrons térmicos. Este trabalho constou da realização de simulações e experimentos visando a implementação da metodologia de dosimetria utilizando o par TLD 600 e TLD 700 e sua comparação com a metodologia atualmente utilizada pelo grupo de pesquisa em BNCT, que utiliza o TLD 400. Portanto, foi realizado um estudo das respostas de cada um destes TLDs a partir de irradiações em diferentes campos e sempre utilizando simulações com o MCNP para fornecer a discriminalização das componentes de dose depositadas em cada TLD. Foram realizadas varias irradiações em campo de gama puro e em campo misto de nêutrons e gamas para o estudo da reprodutibilidade destes TLDs. Este estudo mostrou que mesmo TLDs do mesmo tipo têm sensibilidades distintas, e assim foi criado um Fator de Normalização para cada um dos TLDs, eliminando assim a necessidade de selecionamento. Foi realizado um estudo sobre a diferença das respostas destes TLDs devido à diferentes campos. Este estudo mostrou ser possível estimar o fluxo relativo entre gamas e nêutrons a partir da relação existente entre as duas regiões de interesse dos TLDs 600 e 700. Também foi possível observar que o TLD 700 apresenta resposta para nêutrons, e se a recomendação da ICRU for seguida, a resposta devido à radiação gama será superestimada. Foram obtidas as curvas de calibração dose resposta destes TLDs para campos de gamas puro e campos mistos. Este trabalho propõe o uso desta metodologia com o uso do par TLD 600 e TLD 700, por apresentar maior precisão de resposta frente a atual metodologia que utiliza o TLD 400, porém precauções devem ser tomadas para evitar que a dose gama seja superestimada.Boron Neutron Capture Therapy, BNCT, is a bimodal radiotherapic procedure for cancer treatment. Its usefull energy comes from a nuclear reaction driven by impinging thermal neutron upon Boron 10 atoms. A BNCT research facility has been constructed in IPEN at the IEA-R1 reactor, to develop studies in this area. One of its prime experimental parameter is the beam dosimetry which is nowadays made by using activation foils, for neutron measurements, and TLD 400, for gamma dosimetry. For mixed field dosimetry, the International Commmission on Radiation Units and Measuments, ICRU, recommends the use of pair of detectors with distinct responses to the field components. The TLD 600/ TLD 700 pair meets this criteria, as the amount of 6Li, a nuclide with high thermal neutron cross section, greatily differs in their composition. This work presents a series of experiments and simulations performed in order to implement the mixed field dosimetry based on the use of TLD 600/TLD 700 pair. It also intended to compare this mixed field dosimetric methodology to the one so far used by the BNCT research group of IPEN. The response of all TLDs were studied under irradiations in different irradiation fields and simulations, underwent by MCNP, were run in order to evaluate the dose contribution from each field component. Series of repeated irradiations under pure gamma field and mixed field neutron/gamma field showed differences in the TLD individual responses which led to the adoption of a Normalization Factor. From the use of Normalization Factor the TLD selection it has allowed to overcome TLD selection. TLD responses due to different field components and spectra were studied. It has shown to be possible to evaluate the ralative gamma/neutron fluxes from the relative responses observed in the two Regions of Interest of TLDs glow curves, ROIs, from TLD 600 and TLD 700. It has also been possible to observe the TLD 700 response to neutron, which leads to a gamma dose overstimation when one follows the ICRU recommended mixed field dosimetric procedure. Dose response curves were obtained for the distinct types of TLDs for pure gamma and mixed fields. This work recommends the TLD 600/TLD 700 pair methodology for mixed field dosimetry, this methodology presents a better precision than the one based on TLD 400, however one has to be carefull to avoid gamma dose superestimation.
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Sousa, Edi Carlos Pereira de [UNESP]. "Cinética de cristalização em vidros teluritos do sistema TLWN." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/91983.
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sousa_ecp_me_ilha_prot.pdf: 3838753 bytes, checksum: fb1abbca6e1c68797f42ad16a38d7a47 (MD5)Vidros preparados a partir de massa fundida podem nuclear ou cristalizar novas fases quando são submetidos a tratamentos térmicos acima da temperatura de transição vítrea. Neste traba- lho foram apresentados estudos sobre a cinética de cristalização de vidros teluritos do sistema 80TeO2 –10WO3 –(10–x)Li2 O–xNa2 O, x = 0, 2, 4, 6 e 10% mol, denominado sistema TLWN. As principais teorias sobre nucleação e cristalização de vidros foram detalhadas, tais como: Teoria Clássica de Nucleação, Teoria Clássica de Nucleação Modificada, Teoria de Nucleação Adiabática e Teoria JMAK. Classicamente, o estudo da cristalização de vidros pode ser realizado através da teoria formulada por Johnson–Mehl–Avrami–Kolmogorov (JMAK), a qual descreve os processos de nucleação e cristalização, por intermédio das curvas de calorimetria exploratória diferencial – DSC. Os vidros foram sintetizados pelo método de resfriamento rápido (melt–quenching ). Medidas de DSC foram realizadas a diferentes taxas de aquecimento e com diferentes tama- nhos de partículas para estudar a cinética de cristalização dos vidros. Foi evidenciado o caráter amorfo de alguns vidros e para o vidro TLWN6 foram encontradas diferentes fases cristalinas, tais como: Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α–TeO2 e γ–TeO2 , dispersas na matriz devido aos di- versos tratamentos térmicos realizados em torno das temperaturas correspondentes aos máximos dos picos de cristalização e evidenciadas por DRX. Deconvoluções foram realizadas utilizando funções gaussianas para separar os picos sobrepostos da amostra TLWN6. Ficou evidente, por intermédio da análise dos termogramas, que o número de picos de cristalização aumenta com o incremento do óxido de sódio e também que os vidros teluritos deste sistema não possuem boa estabilidade térmica, quando...
The glasses prepared from the melt mass may crystallize or nuclear new phases when subjected to heat treatment above the glass transition temperature. In this work were presented studies on the kinetics of nucleation and crystallization of glasses tellurite of the system 80TeO2 –10WO3 – (10–x)Li2 O–xNa2 O, x = 0, 2, 4, 6 e 10% mol called TLWN system. The main theories on nucleation and crystallization of glasses have been detailed, such as: Classical Theory of Nucle- ation, Modified Classical Theory of Nucleation, the Nucleation Adiabatic Theory and Theory JMAK. Classically, the study of crystallization of glasses can be performed by theory formu- lated by Johnson–Mehl–Avrami–Kolmogorov (JMAK) which describes processes of nucleation and crystallization through of differential scanning calorimetry curves – DSC. The glasses were synthesized by the method of melt - quenching. DSC measurements were made at different hea- ting rates and with different particle sizes to study the crystallization kinetics of glass. It became evident amorphous character of some glasses and glass TLWN6 different crystalline phases have been found, such as Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α–TeO2 e γ–TeO2 , dispersed in the matrix due to the different heat treatments performed in around the temperatures corresponding to the peak maximum crystallization and evidenced by XRD. Deconvolutions were performed using gaussian functions to separate overlapping peaks TLWN6 sample. It became evident through the examination of thermographs, that the number of peaks of crystallization increases with the increase of sodium oxide and also that this system tellurite glasses do not have good thermal stability when compared to traditional glasses. The activation energies of the crystalline pha- ses were obtained using the... (Complete abstract click electronic access below)
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Sousa, Edi Carlos Pereira de. "Cinética de cristalização em vidros teluritos do sistema TLWN /." Ilha Solteira, 2013. http://hdl.handle.net/11449/91983.
Full textAbstract:
Orientador: Keizo YukimituBanca: João Carlos Silos Moraes
Banca: Walter Maigon Pontuschka
Resumo: Vidros preparados a partir de massa fundida podem nuclear ou cristalizar novas fases quando são submetidos a tratamentos térmicos acima da temperatura de transição vítrea. Neste traba- lho foram apresentados estudos sobre a cinética de cristalização de vidros teluritos do sistema 80TeO2 -10WO3 -(10-x)Li2 O-xNa2 O, x = 0, 2, 4, 6 e 10% mol, denominado sistema TLWN. As principais teorias sobre nucleação e cristalização de vidros foram detalhadas, tais como: Teoria Clássica de Nucleação, Teoria Clássica de Nucleação Modificada, Teoria de Nucleação Adiabática e Teoria JMAK. Classicamente, o estudo da cristalização de vidros pode ser realizado através da teoria formulada por Johnson-Mehl-Avrami-Kolmogorov (JMAK), a qual descreve os processos de nucleação e cristalização, por intermédio das curvas de calorimetria exploratória diferencial - DSC. Os vidros foram sintetizados pelo método de resfriamento rápido (melt-quenching ). Medidas de DSC foram realizadas a diferentes taxas de aquecimento e com diferentes tama- nhos de partículas para estudar a cinética de cristalização dos vidros. Foi evidenciado o caráter amorfo de alguns vidros e para o vidro TLWN6 foram encontradas diferentes fases cristalinas, tais como: Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α-TeO2 e γ-TeO2 , dispersas na matriz devido aos di- versos tratamentos térmicos realizados em torno das temperaturas correspondentes aos máximos dos picos de cristalização e evidenciadas por DRX. Deconvoluções foram realizadas utilizando funções gaussianas para separar os picos sobrepostos da amostra TLWN6. Ficou evidente, por intermédio da análise dos termogramas, que o número de picos de cristalização aumenta com o incremento do óxido de sódio e também que os vidros teluritos deste sistema não possuem boa estabilidade térmica, quando... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The glasses prepared from the melt mass may crystallize or nuclear new phases when subjected to heat treatment above the glass transition temperature. In this work were presented studies on the kinetics of nucleation and crystallization of glasses tellurite of the system 80TeO2 -10WO3 - (10-x)Li2 O-xNa2 O, x = 0, 2, 4, 6 e 10% mol called TLWN system. The main theories on nucleation and crystallization of glasses have been detailed, such as: Classical Theory of Nucle- ation, Modified Classical Theory of Nucleation, the Nucleation Adiabatic Theory and Theory JMAK. Classically, the study of crystallization of glasses can be performed by theory formu- lated by Johnson-Mehl-Avrami-Kolmogorov (JMAK) which describes processes of nucleation and crystallization through of differential scanning calorimetry curves - DSC. The glasses were synthesized by the method of melt - quenching. DSC measurements were made at different hea- ting rates and with different particle sizes to study the crystallization kinetics of glass. It became evident amorphous character of some glasses and glass TLWN6 different crystalline phases have been found, such as Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α-TeO2 e γ-TeO2 , dispersed in the matrix due to the different heat treatments performed in around the temperatures corresponding to the peak maximum crystallization and evidenced by XRD. Deconvolutions were performed using gaussian functions to separate overlapping peaks TLWN6 sample. It became evident through the examination of thermographs, that the number of peaks of crystallization increases with the increase of sodium oxide and also that this system tellurite glasses do not have good thermal stability when compared to traditional glasses. The activation energies of the crystalline pha- ses were obtained using the... (Complete abstract click electronic access below)
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Books on the topic "TLWs"
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Y tlws. Llandysul, Dyfed: Gomer, 1986.
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TLS short stories: From the pages of the TLS. London]: Times Literary Supplement, 2003.
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1939-, Mount Ferdinand, ed. Communism: A TLS companion. Chicago: University of Chicago Press, 1993.
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1939-, Mount Ferdinand, ed. Communism: A TLS companion. Hammersmith, London: Harvill, 1992.
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Corporation, Toshiba. 8-bit microprocessor: TLCS-Z80,85 data book. Tokyo: Toshiba, 1987.
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Toshiba. 8-bit Microcontroller TLCS-90 Series(4). [Japan]: Toshiba, 1995.
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Bauer, Stefan, and Gunther Hartmann, eds. Toll-Like Receptors (TLRs) and Innate Immunity. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-72167-3.
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Prof, Bauer Stefan, Hartmann Gunther 1966-, and Akira S, eds. Toll-like receptors (TLRs) and innate immunity. Berlin: Springer, 2008.
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Corporation, Toshiba. 8-bit microcontroller: TLCS-48, 90 data book. Tokyo: Toshiba, 1987.
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Géographie: TleS : mondialisation et dynamiques géographiques des territoires. Paris: Hachette Éducation, 2014.
Find full textBook chapters on the topic "TLWs"
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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, and I. Savysyuk. "Tl2S." In Structure Types. Part 9: Space Groups (148) R-3 - (141) I41/amd, 386. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02702-4_270.
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Robert, Yves, Sameer Shende, Allen D. Malony, Alan Morris, Wyatt Spear, Scott Biersdorff, Burton Smith, et al. "TLS." In Encyclopedia of Parallel Computing, 2055. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-09766-4_2238.
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de Oliveira Guimarães, Lilian, Renato Barboza, Gerhard Wunderlich, and Karin Kirchgatter. "TLRs in Malaria." In Encyclopedia of Malaria, 1–11. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-8757-9_154-1.
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Easttom, William. "SSL/TLS." In Modern Cryptography, 277–98. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-63115-4_13.
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Sharma, Rahul, and Akshay Mathur. "Configure TLS." In Traefik API Gateway for Microservices, 99–125. Berkeley, CA: Apress, 2020. http://dx.doi.org/10.1007/978-1-4842-6376-1_4.
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Rhodes, Brandon, and John Goerzen. "TLS/SSL." In Foundations of Python Network Programming, 93–114. Berkeley, CA: Apress, 2014. http://dx.doi.org/10.1007/978-1-4302-5855-1_6.
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Nielson, Seth James, and Christopher K. Monson. "TLS Communications." In Practical Cryptography in Python, 293–359. Berkeley, CA: Apress, 2019. http://dx.doi.org/10.1007/978-1-4842-4900-0_8.
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Easttom, Chuck. "SSL/TLS." In Modern Cryptography, 285–307. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-12304-7_13.
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Mehlhorn, Heinz. "Trypanosoma Lytic Factors (TLFs)." In Encyclopedia of Parasitology, 2939. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_4382.
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Mehlhorn, Heinz. "Trypanosoma Lytic Factors (TLFs)." In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_4382-1.
Full textConference papers on the topic "TLWs"
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Medic, Tomislav, Pia Ruttner, Christoph Holst, and Andreas Wieser. "Keypoint-based deformation monitoring using a terrestrial laser scanner from a single station: Case study of a bridge pier." In 5th Joint International Symposium on Deformation Monitoring. Valencia: Editorial de la Universitat Politècnica de València, 2022. http://dx.doi.org/10.4995/jisdm2022.2022.13812.
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Terrestrial laser scanners (TLSs) offer a possibility for more automated and efficient deformation monitoring of civil engineering structures with higher spatial resolution than standard methods, as well as without the necessity of permanently installing the monitoring equipment. In such applications, scanners are usually placed so that the lines of sight are roughly aligned with the main directions of the expected deformations, and the deformations are estimated from point cloud differences between multiple epochs. This allows high sensitivity in the direction of the surface normal, but deformations along the surface are often undetected or hard to precisely quantify. In this work, we propose an algorithm based on the detection and matching of keypoints identified within TLS intensity images. This enables precise quantification of deformations along the scanned surfaces. We also present the application of the algorithm for monitoring a bridge pier of the Hochmoselbrücke in Germany, as a case study. Deformations up to about 4 cm due to thermal expansion and bending of the pier were successfully detected from scans taken throughout the day from a single location, up to 180 m from the monitored surfaces. The results agreed within a few millimeters to independent monitoring using state-of-the-art processing of TLS point clouds obtained from a different location and using a different type/brand of instrument. The newly proposed algorithm can either be used to complement existing TLS-based deformation analysis methods by adding sensitivity in certain directions, or it can be valuable as a standalone solution.
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Elnawawy, Hussein, Rangeen Basu Roy Chowdhury, Amro Awad, and Gregory T. Byrd. "Diligent TLBs." In ICS '19: 2019 International Conference on Supercomputing. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3330345.3330363.
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Deng, Shuwen, Wenjie Xiong, and Jakub Szefer. "Secure TLBs." In ISCA '19: The 46th Annual International Symposium on Computer Architecture. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3307650.3322238.
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Greve, Hannes, S. Ali Moeini, Patrick McCluskey, and Shailesh Joshi. "Prediction and Mitigation of Vertical Cracking in High-Temperature Transient Liquid Phase Sintered Joints by Thermo-Mechanical Simulation." In ASME 2017 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems collocated with the ASME 2017 Conference on Information Storage and Processing Systems. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/ipack2017-74138.
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Transient Liquid Phase Sintering (TLPS) is a novel high temperature attach technology. It is of particular interest for application as a die attach in power electronic systems because of its high melting temperature and high thermal conductivity. TLPS joints formed from sinter pastes are comprised of metallic particles embedded in matrices of Intermetallic Compounds (IMCs). Compared to conventional solder attach, TLPS joints contain a considerably higher percentage of brittle IMCs. This raises the concern that TLPS joints are susceptible to brittle failure. In this paper we describe and analyze the cooling-induced formation of vertical cracks as a newly detected failure mechanism unique to TLPS joints. In a power module structure with a TLPS joint as interconnect between a power device and a Direct Bond Copper (DBC) substrate, cracks can form between the interface of the DBC and the TLPS joint when large voids are located in the proximity of the DBC. These cracks do not appear in regions with smaller voids. A method has been developed for the three-dimensional modeling of paste-based TLPS sinter joints that possess complex microstructures with heterogeneous distributions of metal particles and voids in IMC matrices. Thermo-mechanical simulations of the post-sintering cooling process have been performed and the influence of microstructure on the stress-response within the joint and at the joint interfaces have been characterized for three different material systems (Cu+Cu6Sn5, Cu+Cu3Sn, Ni+Ni3Sn4). The maximum principal stress within the assembly was found to be a poor indicator for prediction of vertical crack formation. In contrast, stress levels at the interface between the TLPS joint and the power substrate metallization are good indicators for this failure mechanism. Small voids lead to higher joint maximum principal stresses, but large voids induce higher interfacial stresses, which explain why the vertical cracking failure was only observed in joints with large voids.
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Hunter, A. F., R. A. Zimmer, W. J. Wang, J. D. Bozeman, C. J. Adams, and B. L. Rager. "Designing the TLWP." In Offshore Technology Conference. Offshore Technology Conference, 1990. http://dx.doi.org/10.4043/6360-ms.
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KAISER, ISAIAH, CHAO ZHANG, and K. T. TAN. "FAILURE OF CFRP AND TITANIUM TUBULAR ADHESIVE LAP JOINTS AT EXTREME TEMPERATURES." In Thirty-sixth Technical Conference. Destech Publications, Inc., 2021. http://dx.doi.org/10.12783/asc36/35948.
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In this work, carbon fiber reinforced polymer and titanium adhesive tubular lap- joints (TLJs) at cold-temperature, room-temperature, and elevated-temperature are studied. Finite element analysis is employed to investigate the competing damage mechanisms within the TLJs. The relationship between the joint strength and adhesive bondline length is also determined. X-ray micro-computed tomography (μCT) technique is utilized to analyze composite damage characteristics; whilst statistical design of experiment (DoE) approach is used to understand the interaction between bondline length and temperature on the mechanical performance of TLJs. Results show a mixed-mode failure region at elevated-temperatures, causing the TLJ to fail by either interlaminar shear or titanium net-section fracture. Results further reveal that deformation within the titanium creates shear stresses on the composite tube, leading to the initiation, propagation, and coalescence of delamination. Employing numerical, experimental, and statistical techniques, this works provides insights into the parameters and mechanisms affecting the behavior and failure of adhesive TLJs at extreme temperature conditions.
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Ferguson, James R. "Simultaneous Thermochromic Liquid Crystal Calibration and Calculation of Heat Transfer Coefficients." In ASME Turbo Expo 2007: Power for Land, Sea, and Air. ASMEDC, 2007. http://dx.doi.org/10.1115/gt2007-28124.
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The use of thermochromic liquid crystals (TLCs) to indicate surface temperature in transient experiments designed to measure heat transfer coefficients requires careful calibration of the crystals. The calibration can be affected by lighting and viewing angles, light source spectral characteristics, surface preparation, and application procedure of the TLCs. A method is proposed whereby the calibration of the TLCs and calculation of heat transfer coefficients are conducted simultaneously using inverse techniques for the case of a suddenly heated semi-infinite wall. The calibration inherently accounts for the problems typically associated with the use of liquid crystals and results from simulated experiments indicate accuracy to within five percent is possible.
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Roth, Timothy B., and Ann M. Anderson. "Light Transmission Characteristics of Thermochromic Liquid Crystals." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81812.
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This paper presents the results of a study to develop a novel thermochromic liquid crystal (TLC) temperature measurement system that uses light transmission instead of light reflection. We used Imagetherm 25C10W sprayable TLCs. The TLCs were painted on a clear surface and placed in a spectrometer. The amount of light transmitted at monochromatic wavelengths from 400 to 700 nm was measured for temperatures from 25–55 C under conditions of non-polarized, linearly polarized and cross polarized light. The transmission spectra exhibit a distinct “s-like” shape when the TLCs are in their active range. We detect significant changes in the transmission spectra for temperatures from 27 to 48 C (whereas in reflection the TLCs are useful over a significantly smaller range). We have analyzed the spectrometer data in a number of ways including (a) total amount of light transmitted (b) amount of red, green and blue light transmitted, and (c) spectral curve characteristics (peak transmission, inflection wavelength and wavelength for peak transmission) all as a function of temperature. There is a linear relationship between temperature and all of these variables which we believe can be exploited in the development of a CCD camera based light transmission system. We also investigated the effects of temperature overheat on the transmission spectra. Overheating the TLCs increases the amount of light transmission.
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Gutierrez, Erick, Subramani Manoharan, Maxim Serebreni, and Patrick McCluskey. "Mechanical Characterization of Transient Liquid Phase Sintered (TLPS) Cu-Sn." In ASME 2018 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/ipack2018-8392.
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The increasing thermal demands in power electronic systems require the application of high temperature die attach materials. Transient Liquid Phase Sintered (TLPS) paste-based solder alloys have been demonstrated to effectively manage the thermal and mechanical load requirements of power modules. The microstructural features of these alloys provide interconnects with the necessary strength required to sustain high loads at high temperatures. To properly understand the influence of microstructure on mechanical behavior of these alloys, single lap shear experiments were performed on a TLPS system consisting of Copper and Tin particles (Cu-Sn). Nano-indentation measurements were performed on intermetallic phases of the TLPS, and the results obtained from lap shear testing and nano-indentation measurements are presented.
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Molin, Bernard, Fabien Remy, and Julien Bonnici. "Experimental and Numerical Studies of Axisymmetric Tuned Liquid Dampers." In ASME 2015 34th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/omae2015-41364.
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Tuned Liquid Dampers (TLDs) have proved their efficiency to mitigate the vibratory response of slender buildings under wind or earthquake excitation. Simple semi-analytical models are proposed here to derive the hydrodynamic coefficients (added mass and damping) of axisymmetric TLDs fitted with circular or radial perforated screens. Comparisons are made with experimental values obtained with an Hexapode test bench. Good agreement is observed.
Reports on the topic "TLWs"
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Fluhr, Robert, and Maor Bar-Peled. Novel Lectin Controls Wound-responses in Arabidopsis. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7697123.bard.
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Innate immune responses in animals and plants involve receptors that recognize microbe-associated molecules. In plants, one set of this defense system is characterized by large families of TIR–nucleotide binding site–leucine-rich repeat (TIR-NBS-LRR) resistance genes. The direct interaction between plant proteins harboring the TIR domain with proteins that transmit and facilitate a signaling pathway has yet to be shown. The Arabidopsis genome encodes TIR-domain containing genes that lack NBS and LRR whose functions are unknown. Here we investigated the functional role of such protein, TLW1 (TIR LECTIN WOUNDRESPONSIVE1). The TLW1 gene encodes a protein with two domains: a TIR domain linked to a lectin-containing domain. Our specific aim in this proposal was to examine the ramifications of the TL1-glycan interaction by; A) The functional characterization of TL1 activity in the context of plant wound response and B) Examine the hypothesis that wounding induced specific polysaccharides and examine them as candidates for TL-1 interactive glycan compounds. The Weizmann group showed TLW1 transcripts are rapidly induced by wounding in a JA-independent pathway and T-DNA-tagged tlw1 mutants that lack TLW1 transcripts, fail to initiate the full systemic wound response. Transcriptome methodology analysis was set up and transcriptome analyses indicates a two-fold reduced level of JA-responsive but not JA-independent transcripts. The TIR domain of TLW1 was found to interact directly with the KAT2/PED1 gene product responsible for the final b-oxidation steps in peroxisomal-basedJA biosynthesis. To identify potential binding target(s) of TL1 in plant wound response, the CCRC group first expressed recombinant TL1 in bacterial cells and optimized conditions for the protein expression. TL1 was most highly expressed in ArcticExpress cell line. Different types of extraction buffers and extraction methods were used to prepare plant extracts for TL1 binding assay. Optimized condition for glycan labeling was determined, and 2-aminobenzamide was used to label plant extracts. Sensitivity of MALDI and LC-MS using standard glycans. THAP (2,4,6- Trihydroxyacetophenone) showed minimal background peaks at positive mode of MALDI, however, it was insensitive with a minimum detection level of 100 ng. Using LC-MS, sensitivity was highly increased enough to detect 30 pmol concentration. However, patterns of total glycans displayed no significant difference between different extraction conditions when samples were separated with Dionex ICS-2000 ion chromatography system. Transgenic plants over-expressing lectin domains were generated to obtain active lectin domain in plant cells. Insertion of the overexpression construct into the plant genome was confirmed by antibiotic selection and genomic DNA PCR. However, RT-PCR analysis was not able to detect increased level of the transcripts. Binding ability of azelaic acid to recombinant TL1. Azelaic acid was detected in GST-TL1 elution fraction, however, DHB matrix has the same mass in background signals, which needs to be further tested on other matrices. The major findings showed the importance of TLW1 in regulating wound response. The findings demonstrate completely novel and unexpected TIR domain interactions and reveal a control nexus and mechanism that contributes to the propagation of wound responses in Arabidopsis. The implications are to our understanding of the function of TIR domains and to the notion that early molecular events occur systemically within minutes of a plant sustaining a wound. A WEB site (http://genome.weizmann.ac.il/hormonometer/) was set up that enables scientists to interact with a collated plant hormone database.
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Moriarty, K., and S. Farrell. Deprecating TLS 1.0 and TLS 1.1. RFC Editor, March 2021. http://dx.doi.org/10.17487/rfc8996.
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Smyth, Ines. Transformative Leadership for Women's Rights (TLWR): Lessons and recommendations from Oxfam's experiences. Oxfam, April 2018. http://dx.doi.org/10.21201/2018.2289.
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The aim of promoting gender equality and women’s rights as integral parts of development efforts is enshrined in the key strategies and plans of many organizations. This is the case for the individual affiliates that comprise Oxfam International (OI), and the Oxfam confederation as a whole. This report sets out to assist Oxfam to better understand and learn from the Confederation’s work in this area to date. The purpose of the report is to provide an initial mapping of work on transformative leadership for women's rights (TLWR) in order to offer suggestions, impetus and a programmatic framework for the development of an ambitious global program on TLWR. It is intended to complement and drive Oxfam’s efforts to bring about the transformation of the pervasive gender inequality that limits women’s wellbeing, confidence and potential, reproduces negative masculinity traits, and contributes to the inequity dominant in contemporary societies.
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Meillier, Yannick. Army TLS. Fort Belvoir, VA: Defense Technical Information Center, November 2014. http://dx.doi.org/10.21236/ada626346.
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Sangster, P., N. Cam-Winget, and J. Salowey. A Posture Transport Protocol over TLS (PT-TLS). RFC Editor, February 2013. http://dx.doi.org/10.17487/rfc6876.
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Rescorla, E. HTTP Over TLS. RFC Editor, May 2000. http://dx.doi.org/10.17487/rfc2818.
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Margolis, D., A. Brotman, B. Ramakrishnan, J. Jones, and M. Risher. SMTP TLS Reporting. RFC Editor, September 2018. http://dx.doi.org/10.17487/rfc8460.
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Ghedini, A., and V. Vasiliev. TLS Certificate Compression. RFC Editor, December 2020. http://dx.doi.org/10.17487/rfc8879.
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Pauly, T., D. Schinazi, and C. A. Wood. TLS Ticket Requests. RFC Editor, April 2022. http://dx.doi.org/10.17487/rfc9149.
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Preuß Mattsson, J., and M. Sethi. EAP-TLS 1.3: Using the Extensible Authentication Protocol with TLS 1.3. RFC Editor, February 2022. http://dx.doi.org/10.17487/rfc9190.
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