Relevant bibliographies by topics / Titanium biomedical implants

Academic literature on the topic 'Titanium biomedical implants'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Titanium biomedical implants"

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Liu, Wei, Shifeng Liu, and Liqiang Wang. "Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications." Coatings 9, no. 4 (April 15, 2019): 249. http://dx.doi.org/10.3390/coatings9040249.

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With the increasing demand for bone implant therapy, titanium alloy has been widely used in the biomedical field. However, various potential applications of titanium alloy implants are easily hampered by their biological inertia. In fact, the interaction of the implant with tissue is critical to the success of the implant. Thus, the implant surface is modified before implantation frequently, which can not only improve the mechanical properties of the implant, but also polish up bioactivity and osseoconductivity on a cellular level. This paper aims at reviewing titanium surface modification techniques for biomedical applications. Additionally, several other significant aspects are described in detail in this article, for example, micromorphology, microstructure evolution that determines mechanical properties, as well as a number of issues concerning about practical application of biomedical implants.
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Li, Jie, Peng Zhou, Shokouh Attarilar, and Hongyuan Shi. "Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants." Coatings 11, no. 6 (May 28, 2021): 647. http://dx.doi.org/10.3390/coatings11060647.

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Due to the growing aging population of the world, and as a result of the increasing need for dental implants and prostheses, the use of titanium and its alloys as implant materials has spread rapidly. Although titanium and its alloys are considered the best metallic materials for biomedical applications, the need for innovative technologies is necessary due to the sensitivity of medical applications and to eliminate any potentially harmful reactions, enhancing the implant-to-bone integration and preventing infection. In this regard, the implant’s surface as the substrate for any reaction is of crucial importance, and it is accurately addressed in this review paper. For constructing this review paper, an internet search was performed on the web of science with these keywords: surface modification techniques, titanium implant, biomedical applications, surface functionalization, etc. Numerous recent papers about titanium and its alloys were selected and reviewed, except for the section on forthcoming modern implants, in which extended research was performed. This review paper aimed to briefly introduce the necessary surface characteristics for biomedical applications and the numerous surface treatment techniques. Specific emphasis was given to micro/nano-structured topographies, biocompatibility, osteogenesis, and bactericidal effects. Additionally, gradient, multi-scale, and hierarchical surfaces with multifunctional properties were discussed. Finally, special attention was paid to modern implants and forthcoming surface modification strategies such as four-dimensional printing, metamaterials, and metasurfaces. This review paper, including traditional and novel surface modification strategies, will pave the way toward designing the next generation of more efficient implants.
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Nhlapo, Nthabiseng, Thywill Cephas Dzogbewu, and Olga de Smidt. "Nanofiber Polymers for Coating Titanium-Based Biomedical Implants." Fibers 10, no. 4 (April 18, 2022): 36. http://dx.doi.org/10.3390/fib10040036.

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The excellent combination of properties has seen a steep increase in the demand for titanium (Ti)-based material as biomedical implant devices. However, some features that promote biocompatibility are found to be lacking in Ti implants. The use of polymer nanofiber (NF) coating on the surfaces of the implants has been proven to remedy these setbacks. In particular, electrospun NFs are versatile as natural extracellular matrix mimics and as facilitators in the biocompatibility function of Ti-based implants. Therefore, various properties of Ti implants coated with polymer NFs and the correlations among these properties are explored in this review. Synthetic polymers are favorable in tissue engineering applications because they are biocompatible and have low toxicity and degradation rates. Several approved synthetic polymers and polymer hybrids have been electrospun onto Ti implant surfaces to successfully improve the biomedical applicability of the implants with regard to their physical (including diameter and porosity), chemical (including corrosion resistance), mechanical (including elastic modulus, strength and ductility) and biological properties (including tissue integration, antimicrobial and cytotoxicity).
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Shayganpour, Amirreza, Alberto Rebaudi, Pierpaolo Cortella, Alberto Diaspro, and Marco Salerno. "Electrochemical coating of dental implants with anodic porous titania for enhanced osteointegration." Beilstein Journal of Nanotechnology 6 (November 20, 2015): 2183–92. http://dx.doi.org/10.3762/bjnano.6.224.

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Clinical long-term osteointegration of titanium-based biomedical devices is the main goal for both dental and orthopedical implants. Both the surface morphology and the possible functionalization of the implant surface are important points. In the last decade, following the success of nanostructured anodic porous alumina, anodic porous titania has also attracted the interest of academic researchers. This material, investigated mainly for its photocatalytic properties and for applications in solar cells, is usually obtained from the anodization of ultrapure titanium. We anodized dental implants made of commercial grade titanium under different experimental conditions and characterized the resulting surface morphology with scanning electron microscopy equipped with an energy dispersive spectrometer. The appearance of nanopores on these implants confirm that anodic porous titania can be obtained not only on ultrapure and flat titanium but also as a conformal coating on curved surfaces of real objects made of industrial titanium alloys. Raman spectroscopy showed that the titania phase obtained is anatase. Furthermore, it was demonstrated that by carrying out the anodization in the presence of electrolyte additives such as magnesium, these can be incorporated into the porous coating. The proposed method for the surface nanostructuring of biomedical implants should allow for integration of conventional microscale treatments such as sandblasting with additive nanoscale patterning. Additional advantages are provided by this material when considering the possible loading of bioactive drugs in the porous cavities.
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Vishwakarma, Vinita, Gobi Saravanan Kaliaraj, and Kamalan Kirubaharan Amirtharaj Mosas. "Multifunctional Coatings on Implant Materials—A Systematic Review of the Current Scenario." Coatings 13, no. 1 (December 30, 2022): 69. http://dx.doi.org/10.3390/coatings13010069.

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The challenges and demands of implant materials are changing as a result of the substantial expansion in the global population. Suitable implants are required for aged people, physical injuries, patients who need revised surgeries, contaminated implants, and accident victims. Hence, the requirement for implants is drastically increasing day by day. Metals, ceramics, and polymers are used as implant materials by biomedical industries for long-term suffering patients. Stainless steel, titanium and its alloys, aluminum alloys, cobalt, zirconium, etc. (metals), hydroxyapatite (ceramic), polyurethane, polyethylene, polyimide, etc. (polymers), are some of the examples that fulfill the implant requirements. There are many other obstructions, such as adhesion, inflammation, and bacterial attack, which minimize the implant’s performance and its activity. However, coatings on ideal implant materials are significant to avoid its failure and to enhance its durability and longevity. Advanced techniques, such as physical and chemical methods, are suitable coating approaches to promote the surface of implants with respect to mechanical, biological, and other multifunctional activities. This review paper focuses on and investigates several strategies for bioactive implants’ coatings, analysis, and emerging applications for biomedical industries.
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Ng, Sabrina Livia, Subhabrata Das, Yen-Peng Ting, Raymond Chung Wen Wong, and Nattharee Chanchareonsook. "Benefits and Biosafety of Use of 3D-Printing Technology for Titanium Biomedical Implants: A Pilot Study in the Rabbit Model." International Journal of Molecular Sciences 22, no. 16 (August 6, 2021): 8480. http://dx.doi.org/10.3390/ijms22168480.

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Background: Titanium has been used in osteosynthesis for decades and its compatibility and safety is unquestioned. Studies have shown that there is release and collection of titanium in the organ systems with little note of toxicity. The gold standard is considered to be titanium osteosynthesis plate produced by milling methods. The use of customized titanium plates produced with 3D printing, specifically direct metal laser sintering, have found increasing use in recent years. It is unknown how much titanium is released in these printed titanium implants, which is known to be potentially porous, depending on the heat settings of the printer. We hypothesize that the amount of titanium released in printed titanium implants may be potentially more or equal compared to the gold standard, which is the implant produced by milling. Methods: We studied the biosafety of this technology and its products by measuring serum and organ titanium levels after implantation of 3D-printed versus traditionally fabrication titanium plates and screws in a pilot study using the rabbit model. A total of nine rabbits were used, with three each in the control, milled and printed titanium group. The animals were euthanized after six months. Serum and organs of the reticuloendothelial system were harvested, digested and assayed for titanium levels. Results: Organ and serum titanium levels were significantly higher in rabbit subjects implanted with titanium implants (milled and printed) compared to the control group. However, there was no significant difference in organ and serum titanium levels of subjects implanted with milled and traditionally fabricated titanium implants. Conclusions: The biosafety of use of 3D-printed titanium implants and traditionally fabricated titanium implants are comparable. With this in mind, 3D-printed custom implants can not only replace, but will very possibly surpass traditionally fabricated titanium implants in the mode and extent of use.
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EKTESSABI, A. M. "Application of micro beam PIXE in biomedical implant research." International Journal of PIXE 06, no. 01n02 (January 1996): 167–80. http://dx.doi.org/10.1142/s012908359600017x.

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The material composition and surface structure of dental and orthopaedic implants influence the integration in bone, and, at the same time, the release of the constituent elements of the implants into the surrounding tissues. Titanium, titanium alloys (Ti-6Al-4V) and other materials which are considered to be biocompatible materials, release metal ions into the surrounding tissues. This may affect the appropriate biological response of the tissues to the implanted materials. The toxicity of some of the constituent elements of these implants, e.g. vanadium, is a matter of serious concern. In this paper, the experimental data on application of PIXE to biomedical-implant research are presented. Two groups of samples were prepared for PIXE analysis. The first group consisted of the specimens that were retrieved from the tissues around implants in 28 rats. The second group consisted of specimens that were sliced and polished to a thickness of a few 10 µm, while keeping the interface between the implant, cortical bone, bone marrow, and soft tissues intact. The implants of the second group, 10 specimens with between 6 and 20 measurement points on each specimen, were used for specifically obtaining the distribution of the released elements with reference to the implant tissue interface, using ion micro beam. The implantation time ranged from 12 weeks to 52 weeks.
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Tailor, Satish, N. Vashishtha, Ankur Modi, and SC Modi. "Thermally Sprayed Porous PEEK Coating for Biomedical Implants." Journal of Thermal Spray and Engineering 1, no. 1 (2018): 32–36. http://dx.doi.org/10.52687/2582-1474/116.

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The present study reports the novel results of microstructural and mechanical properties of highly porous Polyetheretherketone (PEEK) coating. PEEK is already considered as a material for biomedical implants. A new kind of approach is proposed for manufacturing of highly porous PEEK coating on a dense PEEK coating for orthopedic implants and successfully implemented to create novel biomimetic porous PEEK coating by means of thermal spray process. To imitate the structure of natural bone, as-sprayed top PEEK coating has porosity of more than 60% vol. and pore sizes of 30-80 μm. Mechanical results of dense PEEK coating show that PEEK coating exhibited good strength, hardness (20 HV0.1) and good bonding strength (15 MPa) with the metal substrate. Thermal sprayed porous PEEK coating that can be used for future implants instead of plasma sprayed titanium coating on dense PEEK implants because porous PEEK improves the bone-implant interface joining compared to plasma-sprayed titanium coating on PEEK.
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Akshaya, S., Praveen Kumar Rowlo, Amey Dukle, and A. Joseph Nathanael. "Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives." Antibiotics 11, no. 12 (November 29, 2022): 1719. http://dx.doi.org/10.3390/antibiotics11121719.

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Titanium and its alloys are widely used as implant materials for biomedical devices owing to their high mechanical strength, biocompatibility, and corrosion resistance. However, there is a significant rise in implant-associated infections (IAIs) leading to revision surgeries, which are more complicated than the original replacement surgery. To reduce the risk of infections, numerous antibacterial agents, e.g., bioactive compounds, metal ions, nanoparticles, antimicrobial peptides, polymers, etc., have been incorporated on the surface of the titanium implant. Various coating methods and surface modification techniques, e.g., micro-arc oxidation (MAO), layer-by-layer (LbL) assembly, plasma electrolytic oxidation (PEO), anodization, magnetron sputtering, and spin coating, are exploited in the race to create a biocompatible, antibacterial titanium implant surface that can simultaneously promote tissue integration around the implant. The nature and surface morphology of implant coatings play an important role in bacterial inhibition and drug delivery. Surface modification of titanium implants with nanostructured materials, such as titanium nanotubes, enhances bone regeneration. Antimicrobial peptides loaded with antibiotics help to achieve sustained drug release and reduce the risk of antibiotic resistance. Additive manufacturing of patient-specific porous titanium implants will have a clear future direction in the development of antimicrobial titanium implants. In this review, a brief overview of the different types of coatings that are used to prevent implant-associated infections and the applications of 3D printing in the development of antibacterial titanium implants is presented.
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Desai, Shrikar R., Kiran Deepak Koulgikar, Nasser Raqe Alqhtani, Ali Robaian Alqahtani, Abdullah Saad Alqahtani, Adel Alenazi, Artak Heboyan, Gustavo V. O. Fernandes, and Mohammed Mustafa. "Three-Dimensional FEA Analysis of the Stress Distribution on Titanium and Graphene Frameworks Supported by 3 or 6-Implant Models." Biomimetics 8, no. 1 (January 1, 2023): 15. http://dx.doi.org/10.3390/biomimetics8010015.

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Titanium is the main component of dental implants. It is also routinely used as a framework material for implant-supported full-arch prostheses due to its low density, biocompatibility, and other mechanical properties. Remarkable mechanical properties such as lesser mass density and higher young’s modulus of graphene have gained popularity among scientists, improving the properties of biomedical implants. Thus, our study aimed to compare the outcome through the von Mises stresses generated on All-on-6 and All-on-3 implant models, as well as on the framework, and evaluate the effect of stress patterns on the crestal bone around implants in the mandible. FEA (Finite Element Analysis) study was carried out using edentulous mandible models. Four 3D FEA models with 3 and 6 implants were used (Model 1: Titanium bar-supported 6 straight implants; Model 2: Graphene bar-supported 6 straight implants; Model 3: Titanium bar-supported 3 implants with 30 degrees-tilted; Model 4: Graphene bar-supported 3 implants with 30 degrees-tilted) in order to simulate endosseous implant designs. The implant measuring 4.2 mm in diameter and 11.5 mm in length were used. The most distal implants in the 3-implant models were placed with angulation of 30 degrees; in 6 implants, they were vertically placed. All the models were analyzed for vertical and oblique axis with a single force magnitude of 100 N. In all four implant models and under loading conditions, the peak stress points were always on the neck of the most distal implant. von Mises stresses were within the normal stress range. In a conventional six-straight implant model supported by a titanium framework, the cortical stress in the region of implants was 25.27 MPa, whereas, in the graphene framework, it was 12.18 MPa. Under vertical load, there was a significant difference in the cortical stress around the tilted implants (30 degrees) in the 3-implant system of titanium and graphene frameworks, respectively, 70.31 MPa and 21.27 MPa. The graphene framework demonstrated better results than the titanium framework for the conventional six-implant system under vertical load, achieving stress of 30.09 MPa and 76.60 MPa, respectively. In the case of the 3-implant system, a significant difference in the bar stress was observed between graphene and titanium, respectively, 256.32 MPa and 180.1 MPa of bar stress. Within the limitation of this study, the peri-implant stresses were decreased using graphene framework models. Hence, it was possible to conclude that the best load-bearing capacity results were found in the graphene framework group compared to the titanium framework for All-on-6 and All-on-3 implant models, even though both materials are reliable options used as framework materials in implant-supported full-arch prostheses.
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Dissertations / Theses on the topic "Titanium biomedical implants"

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Hoffmann, Ilona. "MAGNESIUM-TITANIUM ALLOYS FOR BIOMEDICAL APPLICATIONS." UKnowledge, 2014. http://uknowledge.uky.edu/cme_etds/36.

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Magnesium has been identified as a promising biodegradable implant material because it does not cause systemic toxicity and can reduce stress shielding. However, it corrodes too quickly in the body. Titanium, which is already used ubiquitously for implants, was chosen as the alloying element because of its proven biocompatibility and corrosion resistance in physiological environments. Thus, alloying magnesium with titanium is expected to improve the corrosion resistance of magnesium. Mg-Ti alloys with a titanium content ranging from 5 to 35 at.-% were successfully synthesized by mechanical alloying. Spark plasma sintering was identified as a processing route to consolidate the alloy powders made by ball-milling into bulk material without destroying the alloy structure. This is an important finding as this metastable Mg-Ti alloy can only be heated up to max. 200C° for a limited time without reaching the stable state of separated magnesium and titanium. The superior corrosion behavior of Mg80-Ti20 alloy in a simulated physiological environment was shown through hydrogen evolution tests, where the corrosion rate was drastically reduced compared to pure magnesium and electrochemical measurements revealed an increased potential and resistance compared to pure magnesium. Cytotoxicity tests on murine pre-osteoblastic cells in vitro confirmed that supernatants made from Mg-Ti alloy were no more cytotoxic than supernatants prepared with pure magnesium. Mg and Mg-Ti alloys can also be used to make novel polymer-metal composites, e.g., with poly(lactic-co-glycolic acid) (PLGA) to avoid the polymer’s detrimental pH drop during degradation and alter its degradation pattern. Thus, Mg-Ti alloys can be fabricated and consolidated while achieving improved corrosion resistance and maintaining cytocompatibility. This work opens up the possibility of using Mg-Ti alloys for fracture fixation implants and other biomedical applications.
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Thompson, Rebecca. "Effect of locally delivered alendronic acid on bone formation around porous titanium implants." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116924.

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The purpose of this study was to determine the effects of local delivery ofthe bisphosphonate alendronic acid (AA) on bone formation around, withinand on porous titanium implants. Cylindrical rods 9mm in diameter and90mm in length were coated with either 0.2mg or 1.0mg of AA prior tobilateral surgical implantation into the femoral intramedullary canals of 10experimental canines. Twelve weeks after surgery the femora wereharvested and scanned with micro computed tomography (microCT) prior toprocessing for undecalcified thin section histology and analysis withbackscattered scanning electron microscopy (BSEM). MicroCT analysisshowed that both levels of AA significantly enhanced peri-implant boneformation around the coated implants compared with controls, with the 1.0mg AA dose resulting in a 3.5-fold greater increase than 0.2mg AA. BSEManalysis of peri-implant bone formation correlated very well the microCTanalysis in a direct comparison of matched microCT and histologic sections.BSEM analysis showed no significant effect of either 0.2mg AA or 1.0mg AAon bone-implant apposition or the extent of bone growth into the implantporous coating. This thesis provided valuable guidance on the doseresponse to locally delivered AA and its potential for enhancing the fixationof orthopaedic implants by increasing the amount of bone that forms withinthe immediate peri-implant space.
L'objectif de cette étude était de déterminer les effets d'une administration localedu biphosphonate acide alendronique (AA) sur la formation osseuse sur, autour età l'intérieur d'implants poreux en titanium. Des tiges cyclindriques de 9mm dediamètre et de 90mm de longueur ont été enduites avec 0.2mg ou 1.0mg de AApréalablement à leur implantation chirurgicale bilatérale dans les canaux fémorauxintramédullaires sur 10 canins expérimentaux. Douze semaines après lachirurgie, les fémurs ont été prélevés et scannés par tomodensitométrie (microCT)avant l'histologie de sections minces décalcifiées et l'analyse par microscopie àbalayage d'électrons rétrodiffusés (BSEM). Les analyses microCT ont montréque les deux doses de AA amélioraient significativement la formation osseuse périimplantautour des implants enduits comparativement aux implants contrôles ; ladose de 1.0mg de AA résultant en une augmentation 3.5 fois supérieure à celleobtenue avec la dose de 0.2mg de AA. Les analyses BSEM de la formationosseuse péri-implant ont montré une bonne corrélation avec les analyses microCTpar une comparaison directe des sections correspondantes microCT ethistologiques. Les analyses BSEM n'ont montré d'effet significatif ni de la dose0.2mg ou 1.0mg AA sur l'apposition os-implant ou sur le niveau de croissanceosseuse dans l'implant poreux enduit. Cette thèse a permis de fournir desdonnées utiles sur la dose réponse pour une administration locale de AA ainsi quesur son potentiel pour améliorer la fixation d'implants orthopédiques en accroissantla quantité osseuse qui se forme aux environs immédiats de la zone péri-implant.
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Ayyala, Somayajula Dilip. "Biocompatibility of osteoblast cells on titanium implants." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1207322725.

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Ehrensberger, Mark T. "The in-vitro biological and electrochemical interactions of electrically polarized commercially pure titanium used for orthopedic and dental applications." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available, full text:, 2008. http://wwwlib.umi.com/cr/syr/main.

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Sosale, Guruprasad. "Measurement and analysis of surface topography over multiple length scales: application to titanium bone implants." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18433.

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The performance of bone (osseous) implants is critically dependent on the interactions of the implant surface with the surrounding osseous tissue. Correlating surface topography with bioperformance is essential for the optimized design of osseous implants. The goal of this thesis is to develop a robust methodology for the measurement and analysis of aperiodic surface topographies, such as those encountered on bone implants, over multiple length scales. Two widely used measurement techniques, namely, Atomic Force Microscopy (AFM) and White-Light Interferometry (WLI), are compared and contrasted. A custom-designed MATLAB-based program is developed to analyze the images from both tools, and to extract fourteen different statistical topography parameters. The errors associated with measurement and image analysis are identified, and guidelines are suggested to minimize their effect. This methodology is then applied to measure the topographies of two commonly-used titanium implant surfaces. Previous studies have shown that both surfaces have similar average (root-mean-square) roughness but elicit significantly different bioresponses. Here, it is demonstrated that the two surfaces differ in several other topography parameters, most significantly in surface slope, peak curvature, and developed interfacial area, and crucially, that these differences are strongly scale dependent. These findings form the basis for devising robust quantitative topography-performance correlations for titanium bone implants.
La performance des implants osseux dépend de façon critique de l'interaction entre la surface de l'implant et le tissu osseux environment. Le but de cette thèse est de développer une méthodologie fiable pour mesurer et analyser la topographie de surfaces non périodiques à différentes échelles. Ainsi, deux techniques de mesure extrêmement utilisées, la microscopie à force atomique et l'interférométrie à lumière blanche ont été comparées et confrontées. Un programme développé sur le logiciel MATLAB a été conçu pour analyser les images obtenues par ses deux instruments et en extraire quatorze différents paramètres topographiques statistiques. Les erreurs associées à la mesure et à l'analyse d'image ont été ensuite identifiées et des recommandations ont été suggérées pour minimiser leurs effets. Cette méthodologie a été ensuite appliquée pour mesurer les topographies de deux implants en titane communément utilisés. Il apparaît que ces deux surfaces ont une moyenne quadratique similaire pour la rugosité, mais présentent néanmoins des réponses biologiques différentes. Dans cette recherche, il a été démontré que les deux surfaces présentent, en plus, plusieurs différences pour d'autres paramètres topographiques, notamment de façon significative, pour l'inclinaison des surfaces, la courbure des pics et l'aire interraciale développée. Ces différences dépendent fortement d'un facteur d'échelle, et forment la base pour d'autres études afin de développer des relations quantitatives entre la topologie de la surface et les réponses biologiques associées.
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Yeung, Che-yan, and 楊芷茵. "Antibacterial properties and biocompatibility of novel peptide incorporated titanium alloy biomaterials for orthopaedic implants." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hdl.handle.net/10722/197133.

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Fang, Mimi. "The role of phospholipase d in osteoblasts in response to titanium surfaces." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26462.

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Thesis (M.S.)--Biomedical Engineering, Georgia Institute of Technology, 2009.
Committee Chair: Boyan, Barbara; Committee Member: Eskin, Suzanne; Committee Member: Lobachev, Kirill; Committee Member: Schwartz, Zvi. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Siddiqui, Mohammad S. "Vacuum Brazing of Alumina Ceramic to Titanium Using Pure Gold as Filler Metal for Biomedical Implants." FIU Digital Commons, 2011. http://digitalcommons.fiu.edu/etd/497.

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One of the many promising applications of metal/ceramic joining is in biomedical implantable devices. This work is focused on vacuum brazing of C.P titanium to 96% alumina ceramic using pure gold as the filler metal. A novel method of brazing is developed where resistance heating of C.P titanium is done inside a thermal evaporator using a Ta heating electrode. The design of electrode is optimized using Ansys resistive heating simulations. The materials chosen in this study are biocompatible and have prior history in implantable devices approved by FDA. This research is part of Boston Retinal implant project to make a biocompatible implantable device (www.bostonretina.org). Pure gold braze has been used in the construction of single terminal feedthrough in low density hermetic packages utilizing a single platinum pin brazed to an alumina or sapphire ceramic donut ( brazed to a titanium case or ferrule for many years in implantable pacemakers. Pure gold (99.99%) brazing of 96% alumina ceramic with CP titanium has been performed and evaluated in this dissertation. Brazing has been done by using electrical resistance heating. The 96% alumina ceramic disk was manufactured by high temperature cofired ceramic (HTCC) processing while the Ti ferrule and gold performs were purchased from outside. Hermetic joints having leak rate of the order of 1.6 X 10-8 atm-cc/ sec on a helium leak detector were measured. Alumina ceramics made by HTCC processing were centreless grounded utilizing 800 grit diamond wheel to provide a smooth surface for sputtering of a thin film of Nb. Since pure alumina demonstrates no adhesion or wetting to gold, an adhesion layer must be used on the alumina surface. Niobium (Nb), Tantalum (Ta) and Tungsten (W) were chosen for evaluation since all are refractory (less dissolution into molten gold), all form stable oxides (necessary for adhesion to alumina) and all are readily thin film deposited as metals. Wetting studies are also performed to determine the wetting angle of pure gold to Ti, Ta, Nb and W substrates. Nano tribological scratch testing of thin film of Nb (which demonstrated the best wetting properties towards gold) on polished 96% alumina ceramic is performed to determine the adhesion strength of thin film to the substrate. The wetting studies also determined the thickness of the intermetallic compounds layers formed between Ti and gold, reaction microstructure and the dissolution of the metal into the molten gold.
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Leung, Kit-ying. "Anti-bacteria plasma-treated metallic surface for orthopaedics use." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41633994.

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Park, Hyuen Me (Mia) Park. "Numerical and experimental analysis of stress behavior of plasma-sprayed Bioglass on titanium /." Full text open access at:, 1996. http://content.ohsu.edu/u?/etd,587.

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Books on the topic "Titanium biomedical implants"

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Titanium Alloys for Biomedical Implants and Devices. MDPI, 2021. http://dx.doi.org/10.3390/books978-3-0365-0003-4.

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Narayan, Roger J., ed. Additive Manufacturing in Biomedical Applications. ASM International, 2022. http://dx.doi.org/10.31399/asm.hb.v23a.9781627083928.

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Volume 23A provides a comprehensive review of established and emerging 3D printing and bioprinting approaches for biomedical applications, and expansive coverage of various feedstock materials for 3D printing. The Volume includes articles on 3D printing and bioprinting of surgical models, surgical implants, and other medical devices. The introductory section considers developments and trends in additively manufactured medical devices and material aspects of additively manufactured medical devices. The polymer section considers vat polymerization and powder-bed fusion of polymers. The ceramics section contains articles on binder jet additive manufacturing and selective laser sintering of ceramics for medical applications. The metals section includes articles on additive manufacturing of stainless steel, titanium alloy, and cobalt-chromium alloy biomedical devices. The bioprinting section considers laser-induced forward transfer, piezoelectric jetting, microvalve jetting, plotting, pneumatic extrusion, and electrospinning of biomaterials. Finally, the applications section includes articles on additive manufacturing of personalized surgical instruments, orthotics, dentures, crowns and bridges, implantable energy harvesting devices, and pharmaceuticals. For information on the print version of Volume 23A, ISBN: 978-1-62708-390-4, follow this link.
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Book chapters on the topic "Titanium biomedical implants"

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Meena, Vijay Kumar, Prashant Kumar, Tarun Panchal, Parveen Kalra, and Ravindra Kumar Sinha. "Investigation of Titanium Lattice Structures for Biomedical Implants." In Advanced Materials for Biomechanical Applications, 159–68. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003286806-8.

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Wirth, Jonathan, and Lobat Tayebi. "Engineering of Dental Titanium Implants and Their Coating Techniques." In Applications of Biomedical Engineering in Dentistry, 149–60. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21583-5_6.

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Sarinnaphakorn, Lertrit, P. Mesquida, C. Giordano, E. Sandrini, R. Chiesa, A. Cigada, M. Fenlon, and L. Di Silvio. "Physicochemical Properties and Biological Response of Titanium Surface Modified by Anodic Spark Deposition for Dental Implants." In 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006, 126–29. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-68017-8_32.

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Uzumaki, E. T., and C. S. Lambert. "Characterization of Titanium Oxide Thin Films Produced by Plasma Immersion Ion Implantation for Biomedical Implants." In Bioceramics 20, 673–76. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-457-x.673.

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Elgazzar, Haytham, and Khalid Abdelghany. "Recent Research Progress and Future Prospects in the Additive Manufacturing of Biomedical Magnesium and Titanium Implants." In Additive and Subtractive Manufacturing Processes, 145–61. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003327394-8.

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Doan, N., Z. Du, J. Xiao, P. Reher, W. Xia, R. Crawford, P. Reher, et al. "The Effects of Simvastatin on Osseo-Integration Around Titanium Implants in Posterior Maxilla of Osteoporotic Rats." In 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6), 609–13. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4361-1_104.

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Pavón, J., O. Galvis, F. Echeverría, J. G. Castaño, M. Echeverry, S. Robledo, E. Jiménez-Piqué, A. Mestra, and M. Anglada. "Anodic oxidation of titanium for implants and prosthesis: processing, characterization and potential improvement of osteointegration." In V Latin American Congress on Biomedical Engineering CLAIB 2011 May 16-21, 2011, Habana, Cuba, 176–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-21198-0_45.

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Doan, N., Z. Du, J. Xiao, P. Reher, W. Xia, R. Crawford, P. Reher, et al. "An Evaluation on the Effect of Osteoporosis on Osseointegration Around Titanium Implants in Posterior Maxilla Following a Tooth Extraction." In 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6), 603–7. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4361-1_103.

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Zemtsova, E. G., A. Yu Arbenin, R. Z. Valiev, and V. M. Smirnov. "Improvement of the Mechanical and Biomedical Properties of Implants via the Production of Nanocomposite Based on Nanostructured Titanium Matrix and Bioactive Nanocoating." In Proceedings of the Scientific-Practical Conference "Research and Development - 2016", 461–68. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62870-7_49.

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Oscar, Decco, Beltrán Victor, Zuchuat Jésica, and Gudiño Romina. "Comparative In Vitro Study of Surface Treatment of Grade II Titanium Biomedical Implant." In VI Latin American Congress on Biomedical Engineering CLAIB 2014, Paraná, Argentina 29, 30 & 31 October 2014, 183–86. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13117-7_48.

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Conference papers on the topic "Titanium biomedical implants"

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Shokuhfar, Tolou, C. K. Choi, and Craig Friedrich. "Hydrophilic Nanotube Coating of Ti Implant Materials for Potential Rapid Bone Regeneration." In ASME 2010 5th Frontiers in Biomedical Devices Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/biomed2010-32056.

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The properties of implant materials used in humans may have important influences on the outcomes of clinical treatments. Recently, titanium and titanium alloys have been extensively employed as in-vivo implant materials, due to their generally favorable biocompatibility, high resistance to corrosion, and relatively low cost. On the other hand, even when using chemically identical materials, the biocompatibility of an implant or its stability depends heavily on its surface structure, as well as the thickness and properties of the surface oxide film. As the characteristics of the implant surface have been reported to play an important role in the in-vivo reactions of implants, a great deal of interest has recently been focused on different surface treatment methods. Currently, there are a variety of methods with which titanium implant surfaces are treated. The anodizing method is an electrochemical technique, which forms a rough, thick oxidized capsule with nanotubular structures on the implant surface. To increase the biocompatibility and bone regeneration and to improve the current shortcomings of Ti and Ti alloy (Ti6Al4V)implants, we applied a uniquely fabricated nanotubular coating over the surface of such implants.
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Ersen, Gizem, Gozde Bulus, Yagmur Birgi, and Feride Sermin Utku. "Alkaline and acidic anodization of titanium implants using electrochemistry." In 2014 18th National Biomedical Engineering Meeting (BIYOMUT). IEEE, 2014. http://dx.doi.org/10.1109/biyomut.2014.7026346.

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Ritchie, R. O. "Damage Tolerance in Biomedical Implants: Cardiac Valves and Endovascular Stents." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2671.

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Abstract The human heat rate is roughly 40 million beats per year. To prosthetic implants such as mechanical heart valves and endovascular stents, this means that they must endure almost 109 fatigue cycles during the patient’s lifetime. To prevent premature mechanical failures of such devices, which inevitably lead to patient fatalities, considerations of damage-tolerant design and life-prediction methodologies represent a preferred approach. In this presentation, a damage-tolerant approach to life prediction and “quality control” for both metallic and ceramic heart valve prostheses is presented, based on the notion that the useful life of the device is governed by the time for incipient defects in the material to propagate, by stress corrosion or more critically fatigue, to failure. Based on these analyses, the relative benefits of metallic (Co-Cr, Ti-6Al-4V) vs. ceramic (pyrolytic carbon) valves are discussed. Finally, analogous considerations are presented for endovascular stents, particularly those processed by laser cutting of the superelastic Ni-Ti alloy Nitinol. Again, the relative benefits of Nitinol vs. more traditional metallic implant materials (stainless steel, Co-Cr, titanium, titanium alloys) are discussed.
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Castelan, Jovani, Vilson Gruber, and Anderson Daleffe. "Biomechanical characteristics of commercially pure titanium sheets and its application in cranial implants." In Biomedical Engineering. Calgary,AB,Canada: ACTAPRESS, 2010. http://dx.doi.org/10.2316/p.2010.723-080.

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Soboyejo, W. O., C. Mercer, S. Allameh, B. Nemetski, N. Marcantonio, and J. Ricci. "Microstructural Characterization of Micro-Textured Titanium Surfaces." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2674.

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Abstract This paper presents the results of a multi-scale microstructural characterization of micro-textured Ti-6Al-4V surfaces that are used in biomedical implants. The hierarchies of substructural and microstructural features associated with laser micro-texturing, polishing and surface blasting with alumina pellets are elucidated via atomic force microscopy (AFM), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and optical microscopy (OM). The nano-scale roughness profiles associated with the different surface textures are elucidated via AFM. Sub-micron precipitates and dislocation substructures associated with wrought processing and laser processing are revealed by TEM. Micro- and meso-scale images of the groove structures are then discussed using OM and SEM. The implications of the results are discussed for the optimization of laser processing schemes for the fabrication of micro-textured surfaces that will facilitate the self organization of proteins, and the attachment of mammalian cells to the Ti-6Al-4V surfaces in biomedical implants.
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Gruenwald, W., and D. Jansen. "A digital low frequency transceiver for biomedical implants with enclosed titanium housing." In 2012 International Conference on Signals and Electronic Systems (ICSES 2012). IEEE, 2012. http://dx.doi.org/10.1109/icses.2012.6382261.

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Lawand, N. S., H. van Zeijl, P. J. French, J. J. Briaire, and J. H. M. Frijns. "Titanium nitride (TiN) as a gate material in BiCMOS devices for biomedical implants." In 2013 IEEE Sensors. IEEE, 2013. http://dx.doi.org/10.1109/icsens.2013.6688502.

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Njus, Glen, James Price, Anand Parikh, Snehal Chokhandre, John Konicek, and Richard Navarro. "Multi-Axis Testing of an Elastomeric Prosthetic Lumbar Disc Compared to a Cadaveric Human Disc." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38087.

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As motion preservation implants begin to replace fusion devices for lumbar degenerative disc disease, preclinical mechanical testing of these devices is critical to predicting their in vivo safety and efficacy. ISO and ASTM standards committees have tried for years to develop a universal test standard for all lumbar disc implants. The eDisc, an elastomeric/titanium disc replacement, is substantially different in its mechanical performance than the Synthes ProDisc or J&J Charite disc. These discs rely on ball and socket motion about a fixed or moving center or rotation to provide motion restoration in 3 to 5 axes. In contrast, the eDisc has viscoelastic motion in 3 translation and 3 rotational directions, just as in the natural human disc.
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Trentin, A., S. Vezzù, S. Rech, S. Gulizia, and M. Jahedi. "Biocompatibility of Titanium Coatings Deposits on CoCr by Cold Spray." In ITSC2011, edited by B. R. Marple, A. Agarwal, M. M. Hyland, Y. C. Lau, C. J. Li, R. S. Lima, and A. McDonald. DVS Media GmbH, 2011. http://dx.doi.org/10.31399/asm.cp.itsc2011p0763.

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Abstract The excellent corrosion resistance and biocompatibility of titanium make of it the material to choose for biomedical applications. Cold spraying, as a new coating technique, can be used to deposit protective Ti coatings onto less performing materials such as stainless steel and Co-Cr alloys, commonly used for biomedical implants. In addition, Cold Spray has the advantage, in comparison with conventional thermal spray techniques, to permit the deposition of oxygen-sensitive materials. In this study, Cold Sprayed Ti coatings were prepared on Co-Cr alloy substrates by using different spray process conditions. The microstructure of coatings was observed by SEM and the inner porosity was estimated by image analysis. Oxygen and nitrogen contents were investigated on a set of free standing deposits obtained using different process parameters. In the same way, the roughness and microhardness of deposits, such as the adhesion strength with the substrate, were measured. Finally, the corrosion performance of the coatings was evaluated by mean of open circuit potential measurement (OCP) and potentiodynamic polarizations scans. The electrochemical response was therefore discussed and compared to the corrosion behaviour of the Co-Cr alloy substrate and the bulk Titanium.
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Satyanarayana, Chelamalasetti Pavan, Lam Ratnaraju, Lam Suvarna Raju, Sreekanth Dondapati, Ravikumar Dumpala, and Ratna Sunil Buradagunta. "Characterization of CP-Ti Processed by Micro Arc Oxidation for Bone Implant Applications." In 1st International Conference on Mechanical Engineering and Emerging Technologies. Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-82dgaz.

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Titanium and its alloys are potential candidates widely used to manufacture medical implants. In spite of possessing excellent properties suitable for a biomaterial, Ti suffers from lack of ability to bond with the local tissue termed as “bioactivity”. Several strategies have been adopted to increase the bioactivity of titanium for bone implant applications. Micro arc oxidation (MAO) is one of such promising surface treatments which produces an oxide layer on the surface of Ti which promote better tissue interactions at the surface Ti. Hence, in the present work, commercial pure Ti (CP-Ti) has been treated with MAO process and the produced surface was characterized to study the oxide layer developed on the Ti surface. X-Ray diffraction studies demonstrated the formation of TiO2 layer on the surface of CP-Ti. Scanning electron microscope images and EDS analysis confirms the porosity in the produced oxide layer which is favorable towards better cell interactions. The presence of considerable amount of phosphorous in the oxide layer which is form the electrolyte used during MAO process was also observed. The preliminary findings demonstrate the simple and effective way to produce porous oxide layer on Ti for biomedical applications.
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