Relevant bibliographies by topics / Tissue engineering. Regenerative Medicine

Academic literature on the topic 'Tissue engineering. Regenerative Medicine'

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Published: 14 March 2023

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Journal articles on the topic "Tissue engineering. Regenerative Medicine"

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Dzobo, Kevin, Nicholas Ekow Thomford, Dimakatso Alice Senthebane, Hendrina Shipanga, Arielle Rowe, Collet Dandara, Michael Pillay, and Keolebogile Shirley Caroline M. Motaung. "Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine." Stem Cells International 2018 (July 30, 2018): 1–24. http://dx.doi.org/10.1155/2018/2495848.

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Humans and animals lose tissues and organs due to congenital defects, trauma, and diseases. The human body has a low regenerative potential as opposed to the urodele amphibians commonly referred to as salamanders. Globally, millions of people would benefit immensely if tissues and organs can be replaced on demand. Traditionally, transplantation of intact tissues and organs has been the bedrock to replace damaged and diseased parts of the body. The sole reliance on transplantation has created a waiting list of people requiring donated tissues and organs, and generally, supply cannot meet the demand. The total cost to society in terms of caring for patients with failing organs and debilitating diseases is enormous. Scientists and clinicians, motivated by the need to develop safe and reliable sources of tissues and organs, have been improving therapies and technologies that can regenerate tissues and in some cases create new tissues altogether. Tissue engineering and/or regenerative medicine are fields of life science employing both engineering and biological principles to create new tissues and organs and to promote the regeneration of damaged or diseased tissues and organs. Major advances and innovations are being made in the fields of tissue engineering and regenerative medicine and have a huge impact on three-dimensional bioprinting (3D bioprinting) of tissues and organs. 3D bioprinting holds great promise for artificial tissue and organ bioprinting, thereby revolutionizing the field of regenerative medicine. This review discusses how recent advances in the field of regenerative medicine and tissue engineering can improve 3D bioprinting and vice versa. Several challenges must be overcome in the application of 3D bioprinting before this disruptive technology is widely used to create organotypic constructs for regenerative medicine.
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Sahoo, Sambit, Thomas KH Teh, Pengfei He, Siew Lok Toh, and James CH Goh. "Interface Tissue Engineering: Next Phase in Musculoskeletal Tissue Repair." Annals of the Academy of Medicine, Singapore 40, no. 5 (May 15, 2011): 245–51. http://dx.doi.org/10.47102/annals-acadmedsg.v40n5p245.

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Increasing incidence of musculoskeletal injuries coupled with limitations in the current treatment options have necessitated tissue engineering and regenerative medicine- based approaches. Moving forward from engineering isolated musculoskeletal tissues, research strategies are now being increasingly focused on repairing and regenerating the interfaces between dissimilar musculoskeletal tissues with the aim to achieve seamless integration of engineered musculoskeletal tissues. This article reviews the state-of-the-art in the tissue engineering of musculoskeletal tissue interfaces with a focus on Singapore’s contribution in this emerging field. Various biomimetic scaffold and cell-based strategies, the use of growth factors, gene therapy and mechanical loading, as well as animal models for functional validation of the tissue engineering strategies are discussed. Keywords: Functional tissue engineering, Orthopaedic interfaces, Regenerative medicine, Scaffolds
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SM, Harsini. "Bone Regenerative Medicine and Bone Grafting." Open Access Journal of Veterinary Science & Research 3, no. 4 (2018): 1–7. http://dx.doi.org/10.23880/oajvsr-16000167.

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Bone tissues can repair and regenerate it: in many clinical cases, bone fractures repair without scar formation. Nevertheless, in large bone defects and pathological fractures, bone healing fail to heal. Bone grafting is defined as implantation of material which promot es fracture healing, through osteoconduction osteogenesis, and osteoinduction. Ideal bone grafting depends on several factors such as defect size, ethical issues, biomechanical characteristics, tissue viability, shape and volume, associated complications, cost, graft size, graft handling, and biological characteristics. The materials that are used as bone graft can be divided into separate major categories, such as autografts, allografts, and xenografts. Synthetic substitutes and tissue - engineered biomateri als are other options. Each of these instances has some advantages and disadvantages. Between the all strategies for improving fracture healing and enhance the outcome of unification of the grafts, tissue engineering is a suitable option. A desirable tissu e - engineered bone must have properties similar to those of autografts without their limitations. None of the used bone grafts has all the ideal properties including low donor morbidity, long shelf life, efficient cost, biological safety, no size restrictio n, and osteoconductive, osteoinductive, osteogenic, and angiogenic properties; but Tissue engineering tries to supply most of these features. In addition it is able to induce healing and reconstruction of bone defects. Combining the basis of orthopedic sur gery with knowledge from different sciences like materials science, biology, chemistry, physics, and engineering can overcome the limitations of current therapies. Combining the basis of orthopedic surgery with knowledge from different sciences like materi als science, biology, chemistry, physics, and engineering can overcome the limitations of current therapies.
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Ribitsch, Iris, Gil Lola Oreff, and Florien Jenner. "Regenerative Medicine for Equine Musculoskeletal Diseases." Animals 11, no. 1 (January 19, 2021): 234. http://dx.doi.org/10.3390/ani11010234.

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Musculoskeletal injuries and chronic degenerative diseases commonly affect both athletic and sedentary horses and can entail the end of their athletic careers. The ensuing repair processes frequently do not yield fully functional regeneration of the injured tissues but biomechanically inferior scar or replacement tissue, causing high reinjury rates, degenerative disease progression and chronic morbidity. Regenerative medicine is an emerging, rapidly evolving branch of translational medicine that aims to replace or regenerate cells, tissues, or organs to restore or establish normal function. It includes tissue engineering but also cell-based and cell-free stimulation of endogenous self-repair mechanisms. Some regenerative medicine therapies have made their way into equine clinical practice mainly to treat tendon injures, tendinopathies, cartilage injuries and degenerative joint disorders with promising results. However, the qualitative and quantitative spatiotemporal requirements for specific bioactive factors to trigger tissue regeneration in the injury response are still unknown, and consequently, therapeutic approaches and treatment results are diverse. To exploit the full potential of this burgeoning field of medicine, further research will be required and is ongoing. This review summarises the current knowledge of commonly used regenerative medicine treatments in equine patients and critically discusses their use.
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Filipczak, Nina, Satya Siva Kishan Yalamarty, Xiang Li, Muhammad Muzamil Khan, Farzana Parveen, and Vladimir Torchilin. "Lipid-Based Drug Delivery Systems in Regenerative Medicine." Materials 14, no. 18 (September 17, 2021): 5371. http://dx.doi.org/10.3390/ma14185371.

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The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its natural healing potential. Regenerative medicine utilizes products of cell therapy, as well as biomedical or tissue engineering, and is a huge field for development. In regenerative medicine, stem cells and growth factor are mainly used; thus, innovative drug delivery technologies are being studied for improved delivery. Drug delivery systems offer the protection of therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. Similarly, the delivery systems in combination with stem cells offer improvement of cell survival, differentiation, and engraftment. The present review summarizes the significance of biomaterials in tissue engineering and the importance of colloidal drug delivery systems in providing cells with a local environment that enables them to proliferate and differentiate efficiently, resulting in successful tissue regeneration.
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Yahya, Esam Bashir, A. A. Amirul, Abdul Khalil H.P.S., Niyi Gideon Olaiya, Muhammad Omer Iqbal, Fauziah Jummaat, Atty Sofea A.K., and A. S. Adnan. "Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine." Polymers 13, no. 10 (May 17, 2021): 1612. http://dx.doi.org/10.3390/polym13101612.

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The global transplantation market size was valued at USD 8.4 billion in 2020 and is expected to grow at a compound annual growth rate of 11.5% over the forecast period. The increasing demand for tissue transplantation has inspired researchers to find alternative approaches for making artificial tissues and organs function. The unique physicochemical and biological properties of biopolymers and the attractive structural characteristics of aerogels such as extremely high porosity, ultra low-density, and high surface area make combining these materials of great interest in tissue scaffolding and regenerative medicine applications. Numerous biopolymer aerogel scaffolds have been used to regenerate skin, cartilage, bone, and even heart valves and blood vessels by growing desired cells together with the growth factor in tissue engineering scaffolds. This review focuses on the principle of tissue engineering and regenerative medicine and the role of biopolymer aerogel scaffolds in this field, going through the properties and the desirable characteristics of biopolymers and biopolymer tissue scaffolds in tissue engineering applications. The recent advances of using biopolymer aerogel scaffolds in the regeneration of skin, cartilage, bone, and heart valves are also discussed in the present review. Finally, we highlight the main challenges of biopolymer-based scaffolds and the prospects of using these materials in regenerative medicine.
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TABATA, Yasuhiko. "TISSUE ENGINEERING FOR REGENERATIVE MEDICINE." Japanese jornal of Head and Neck Cancer 28, no. 3 (2002): 573–79. http://dx.doi.org/10.5981/jjhnc1974.28.573.

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Różalska, Barbara, Bartłomiej Micota, Małgorzata Paszkiewicz, and Beata Sadowska. "Tissue engineering in regenerative medicine." Forum Zakażeń 6, no. 5 (November 2, 2015): 291–98. http://dx.doi.org/10.15374/fz2015052.

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Jenkins, D. Denison, George P. Yang, H. Peter Lorenz, Michael T. Longaker, and Karl G. Sylvester. "Tissue engineering and regenerative medicine." Clinics in Plastic Surgery 30, no. 4 (October 2003): 581–88. http://dx.doi.org/10.1016/s0094-1298(03)00076-2.

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Mao, Angelo S., and David J. Mooney. "Regenerative medicine: Current therapies and future directions." Proceedings of the National Academy of Sciences 112, no. 47 (November 24, 2015): 14452–59. http://dx.doi.org/10.1073/pnas.1508520112.

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Organ and tissue loss through disease and injury motivate the development of therapies that can regenerate tissues and decrease reliance on transplantations. Regenerative medicine, an interdisciplinary field that applies engineering and life science principles to promote regeneration, can potentially restore diseased and injured tissues and whole organs. Since the inception of the field several decades ago, a number of regenerative medicine therapies, including those designed for wound healing and orthopedics applications, have received Food and Drug Administration (FDA) approval and are now commercially available. These therapies and other regenerative medicine approaches currently being studied in preclinical and clinical settings will be covered in this review. Specifically, developments in fabricating sophisticated grafts and tissue mimics and technologies for integrating grafts with host vasculature will be discussed. Enhancing the intrinsic regenerative capacity of the host by altering its environment, whether with cell injections or immune modulation, will be addressed, as well as methods for exploiting recently developed cell sources. Finally, we propose directions for current and future regenerative medicine therapies.
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Dissertations / Theses on the topic "Tissue engineering. Regenerative Medicine"

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Tan, Richard Philip. "Developing Translational Tissue Engineering Solutions for Regenerative Medicine." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20200.

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Regenerative medicine is an emerging field that aims to treat injury and disease by harnessing and augmenting the body’s innate capacity for tissue regeneration. Many of the strategies developed in this field have relied extensively on the principles of tissue engineering, a set of methods that bring together cells, cellular signals and material scaffolds to repair or replace biological tissue. While the number of novel tissue engineering strategies continues to rapidly expand, the innovations underlying these solutions often fail to consider the key technical, manufacturing, and regulatory barriers that prohibit these technologies from suitable use in humans. As a result, the field of tissue engineering has one of the lowest rates of clinical translation amongst medical research. To address this, this thesis examines each of the prominent components of the tissue engineering practice and develops tools and strategies that enable the development of solutions with high translational potential. The collective findings of these works propose tools and solutions applicable within the major facets of tissue engineering that may help to lay the groundwork for future therapies with high clinical probability in a number of regenerative medicine applications.
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Ueda, Yuichiro. "Application of Tissue Engineering with Xenogenic Cells and Tissues for Regenerative Medicine." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147657.

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MUSCOLINO, Emanuela. "Polysaccharide hydrogels for regenerative medicine applications." Doctoral thesis, Università degli Studi di Palermo, 2022. http://hdl.handle.net/10447/535885.

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Speccher, Alessandra. "Tissue engineering approaches for brain injury applications." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/262798.

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Due to the limited regenerative capacity of the central nervous system (CNS) upon injury, regenerative medicine and tissue engineering strategies show great promise for treatment. These aim to restore tissue functions by combining principles of cell biology and engineering, using biomaterial scaffolds which can help in recapitulating the 3D environment of the brain and improving cell survival after grafting. Stroke and TBI are severe forms of disruptions of brain architecture, and two of the leading causes of mortality and morbidity worldwide, as no effective treatments are available. Several studies report how neural stem cells (NSCs) are able to improve functional recovery upon transplantation. However, the efficacy of these treatments is limited because of the mortality these cells are subject to after transplantation. In this context, the transplantation of mesenchymal cells (MSCs) has shown beneficial effects by secreting molecules and factors that help in the healing process. In this study, we tested alginate-based hydrogels as candidates to support human NSCs and MSCs transplantation into the brain, in the view of exploiting the beneficial effects of both and analyzing whether their combined use could have a synergistic effect. In the first part, we studied the suitability of alginate-based scaffolds for the three-dimensional encapsulation and culture of hNSCs and hMSCs. We analyzed their ability to support cell survival, and we evaluated whether changes in their concentration or modifications with ECM molecules could influence cell viability. We showed that the best survival conditions are found when using an RGDs-functionalized alginate scaffold at a low concentration (0.5% w/v). We then worked on the identification of the best conditions for MSCs culture and the definition of coculture conditions. Since serum is necessary for MSCs, but it is reported to induce glial differentiation of NSCs, we explored two different experimental setups. On one hand, we investigated the feasibility to exploit biomaterials to create "compartmentalized" cocultures that would at least partially retain serum. In parallel, we positively observed that MSCs can survive, proliferate and maintain their stemness even in absence of serum, supporting the hypothesis that the use of “compartmentalized” coculture systems would likely be exploitable for MSCs culture. Finally, we tested the reported beneficial effects of MSCs in our 3D culture system, in which NSCs do not show a great viability. Encapsulated NSCs were cultured on an MSCs monolayer, and we analyzed cell survival, proliferation, differentiation and stemness retention. Gene expression analyses highlighted that NSCs maintain stemness characteristics, but we were not able to observe any improvement in NSCs survival in coculture, with respect to standard culture. In the last part of the project we decided to test our system for tissue engineering approaches, exploiting axotomized brain organotypic slices (OSCs). We evaluated the presence of cells 7 days after transplantation, their integration in the OSCs and glial response. Preliminary results suggest that the biomaterial does not cause activation of glial cells, although stem cells do not seem to migrate out of scaffold and integrate into the brain slice.
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Speccher, Alessandra. "Tissue engineering approaches for brain injury applications." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/262798.

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Due to the limited regenerative capacity of the central nervous system (CNS) upon injury, regenerative medicine and tissue engineering strategies show great promise for treatment. These aim to restore tissue functions by combining principles of cell biology and engineering, using biomaterial scaffolds which can help in recapitulating the 3D environment of the brain and improving cell survival after grafting. Stroke and TBI are severe forms of disruptions of brain architecture, and two of the leading causes of mortality and morbidity worldwide, as no effective treatments are available. Several studies report how neural stem cells (NSCs) are able to improve functional recovery upon transplantation. However, the efficacy of these treatments is limited because of the mortality these cells are subject to after transplantation. In this context, the transplantation of mesenchymal cells (MSCs) has shown beneficial effects by secreting molecules and factors that help in the healing process. In this study, we tested alginate-based hydrogels as candidates to support human NSCs and MSCs transplantation into the brain, in the view of exploiting the beneficial effects of both and analyzing whether their combined use could have a synergistic effect. In the first part, we studied the suitability of alginate-based scaffolds for the three-dimensional encapsulation and culture of hNSCs and hMSCs. We analyzed their ability to support cell survival, and we evaluated whether changes in their concentration or modifications with ECM molecules could influence cell viability. We showed that the best survival conditions are found when using an RGDs-functionalized alginate scaffold at a low concentration (0.5% w/v). We then worked on the identification of the best conditions for MSCs culture and the definition of coculture conditions. Since serum is necessary for MSCs, but it is reported to induce glial differentiation of NSCs, we explored two different experimental setups. On one hand, we investigated the feasibility to exploit biomaterials to create "compartmentalized" cocultures that would at least partially retain serum. In parallel, we positively observed that MSCs can survive, proliferate and maintain their stemness even in absence of serum, supporting the hypothesis that the use of “compartmentalized” coculture systems would likely be exploitable for MSCs culture. Finally, we tested the reported beneficial effects of MSCs in our 3D culture system, in which NSCs do not show a great viability. Encapsulated NSCs were cultured on an MSCs monolayer, and we analyzed cell survival, proliferation, differentiation and stemness retention. Gene expression analyses highlighted that NSCs maintain stemness characteristics, but we were not able to observe any improvement in NSCs survival in coculture, with respect to standard culture. In the last part of the project we decided to test our system for tissue engineering approaches, exploiting axotomized brain organotypic slices (OSCs). We evaluated the presence of cells 7 days after transplantation, their integration in the OSCs and glial response. Preliminary results suggest that the biomaterial does not cause activation of glial cells, although stem cells do not seem to migrate out of scaffold and integrate into the brain slice.
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Canseco, José Antoni. "Tissue engineering the anterior cruciate ligament : a regenerative medicine approach in orthopaedic surgery." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83965.

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Thesis (Ph. D. in Biomedical Engineering)--Harvard-MIT Program in Health Sciences and Technology, 2013.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references (pages 85-97).
Anterior cruciate ligament (ACL) injuries affect over 200,000 Americans yearly, and many occur in young athletes. Current treatment options include tendon autografts and cadaveric allografts. However, these approaches often lead to secondary medical problems, such as donor-site morbidity and immune rejection. Furthermore, in younger patients these grafts fail to grow, leading to additional complications and underlining the need for the development of new approaches that improve the healing and repair of ligaments and tendons. This thesis aims to develop a technique to engineer ACL from autologous mesenchymal stem cells (MSC) and primary ACL fibroblasts using the basic principles of Tissue Engineering. The first part of the thesis characterizes MSCs isolated from tibial bone marrow as an alternative to hip-derived marrow aspirates. The proximity of the tibia to the surgical site of ACL reconstructions makes it a viable source of marrow derived-MSCs for ligament repair, with less stress for the patient and increased flexibility in the operating room. Characterization was performed by fluorescenceactivated cell sorting for MSC-surface markers, and assays to differentiate MSCs towards adipogenic, osteogenic and chondrogenic lineages. The second part of the thesis describes the effects of in vitro co-cultures of ACL fibroblast and MSC on the expression of ligament-associated markers. The goal was to optimize the cell-cell ratio in order to maximize the positive effects of co-cultures on ligament regeneration. Co-cultures of ACL fibroblasts and MSCs were studied for 14 and 28 days in vitro, and the effects assessed with quantitative mRNA expression and immunofluorescence of ligament markers Collagen type I, Collagen type III and Tenascin-C. Finally, based on the enhancing effect observed in co-cultures, the thesis explores a method to regenerate ACL using a three-dimensional polyglyconate scaffold seeded with cell-hydrogel suspensions containing ACL fibroblasts and MSCs. Constructs were analyzed biochemically and by immunofluorescence after 4 weeks in culture with and without mechanical stimulation. Together, our results establish an experimental framework from which a new technique for ACL repair can be developed. The ultimate goal is to foster the design of a one-stage surgical procedure for improved primary ACL augmentation repair that can soon be translated into clinical practice.
by José Antonio Canseco.
Ph.D.in Biomedical Engineering
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Smith, Cynthia Miller. "A Direct-Write Three-Dimensional Bioassembly Tool for Regenerative Medicine." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1335%5F1%5Fm.pdf&type=application/pdf.

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Chong, Cassandra. "Improving 3D Scaffolds for Skin Tissue Engineering using Advanced Biotechnology." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16551.

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Existing, dermal, regenerative scaffolds facilitate dermal repair and wound healing of severe burn injuries; however, new tissue is often functionally, mechanically and aesthetically abnormal due to irregular deposition of new extracellular matrix. In the present study two novel, elastin-containing scaffolds were developed, characterised and examined both in vitro and in vivo aiming to minimise wound contraction, improve scar appearance and increase skin elasticity post-healing. The first types of scaffolds were electrospun from a triple polymer solution of collagen, elastin and poly(ϵ-caprolactone) (CEP). Two scaffolds were chosen for characterisation: CEP 1 was fabricated using a 1.5 % (w/v) collagen, 12 % (w/v) elastin and 1.5 % (w/v) poly(ϵ-caprolactone) (PCL) solution, a flow rate of 3 mL/h, an air gap of 15 cm and an applied electric potential of 25 kV; and CEP 2 was electrospun using a 2 % (w/v) collagen, 12 % (w/v) elastin and 1 % (w/v) PCL solution at 1 mL/h, 20 cm and 20 kV. In vitro cell studies using human, dermal fibroblasts (HDFs) and immortalised, human keratinocytes (HaCaTs) revealed CEP 1 and CEP 2 supported cell-seeding and cell proliferation with significantly higher proliferation of both cell types on CEP 1. Additionally, subcutaneous implant studies in mice revealed minimal inflammation in response to both scaffolds with CEP 1 vascularised by week 2 post-surgery. However, CEP 1 was rapidly biodegraded after 2 weeks. Collagen deposition was observed in encapsulating tissue and new tissue with consistent collagen expression over 24 weeks. The second type of scaffold investigated was an elastin-modified version of the commercial, dermal substitute Integra Dermal Regeneration Template (IDRT). Elastin-IDRT (EDRT) was developed by inclusion of 10% human tropoelastin and then investigated in comparison with IDRT. Morphological analysis by scanning electron microscope and mechanical characterisation revealed EDRT had significantly enlarged pores, higher porosity and increased deformability. Higher cell seeding efficiency of HaCaTs on EDRT was observed compared to IDRT but cell proliferation rate was found to be similar over 28 days. HDFs displayed increased cell growth rate on EDRT over 28 days compared to IDRT. Enhanced and accelerated HDF infiltration of EDRT was also visualised with complete infiltration by day 14 post-seeding. An in vivo, mouse, subcutaneous implant model showed that EDRT induced minimal inflammation. Gene expression of mouse collagen was consistent over 24 weeks with non-significant increases in elastin expression from weeks 2 and 4. One-step grafting demonstrated similar contraction between EDRT-, IDRT- and autografted wounds with final contraction around 40 % compared to 100 % in open wounds. EDRT displayed significantly accelerated, early-stage angiogenesis with higher vascularisation than IDRT-grafted, autografted or open wounds 2 weeks post grafting. By week 4 EDRT- and IDRT-grafted wounds had similar levels of vascularisation which were higher than autografted and open wounds. EDRT showed improved mechanical performance, supported enhanced cell interactions in vitro and accelerated angiogenesis in vivo. In summary, investigated scaffolds demonstrated properties that could potentially improve burn wound healing. The inclusion of elastin in scaffolds produced by either electrospinning or lyophilisation improved HDF infiltration and supported formation of a confluent layer of HaCaTs which could result in increased pliability of new skin and accelerated wound healing. In EDRT elastin improved scaffold porosity, pore size and accelerated angiogenesis in vivo indicating EDRT can facilitate and improve wound remodelling. Further investigation of both scaffolds is warranted especially due to the vascular inductive effects of EDRT and the synchronous spatial and temporal biodegradation of CEP 2 observed in vivo.
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Rockwood, Danielle N. "Characterization of electrospun polymer fibers for applications in cardiac tissue engineering and regenerative medicine." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 155 p, 2008. http://proquest.umi.com/pqdweb?did=1459913201&sid=1&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Ahmed, Shehnaz. "Self-reporting scaffolds for in situ monitoring for regenerative medicine and tissue engineering applications." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49511/.

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This thesis describes the development and utilisation of a self-reporting scaffold to improve current monitoring methods of the cellular microenvironment. In vitro tissue models hold a lot of promise for regenerative medicine and tissue engineering. However, many models lack the ability to non-invasively monitor in situ cellular responses in a physiologically relevant environment. By development of electrospun self-reporting scaffolds and incorporation of flow culture conditions, this limitation can be overcome. Electrospun matrices have been shown to mimic the structural architecture of the native extracellular matrix, whilst flow conditions have been shown to regulate cellular processes, and enhance mass transport and nutrient exchange throughout polymeric scaffolds. Here we show the development of optically transparent self-reporting electrospun scaffolds that incorporate ratiometric pH-sensitive nanosensors and respond to biological and mechanical cues of the native extracellular matrix through exposure to shear stress. Optically transparent self-reporting scaffolds were fabricated by directly electrospinning pH responsive, ratiometric nanosensors within a gelatin biopolymer matrix. The sensors consist of a porous polyacrylamide matrix which encapsulates pH-sensitive fluorophores that exhibit an additive fluorescent response across the full physiological range between pH 3-8, and a pH-insensitive reference fluorophore. The self-reporting scaffold was able to support cell growth whilst being able to simultaneously monitor local pH changes in real time. A Quasi-Vivo® bioreactor system was also used to generate a flow of cell culture medium and expose cell-seeded scaffolds to a continual shear stress. This novel diagnostic scaffold and the use of flow conditions can help simulate enhance the understanding of in vitro conditions, and generate advanced simulations in vivo to facilitate tissue engineering and regenerative medicine applications.
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Books on the topic "Tissue engineering. Regenerative Medicine"

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Tissue engineering in regenerative medicine. New York: Humana Press, 2011.

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Bernstein, Harold S., ed. Tissue Engineering in Regenerative Medicine. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-322-6.

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Pham, Phuc Van, ed. Tissue Engineering and Regenerative Medicine. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-19857-2.

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Bhaskar, Birru, Parcha Sreenivasa Rao, Naresh Kasoju, Vasagiri Nagarjuna, and Rama Raju Baadhe, eds. Biomaterials in Tissue Engineering and Regenerative Medicine. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0002-9.

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Holnthoner, Wolfgang, Andrea Banfi, James Kirkpatrick, and Heinz Redl, eds. Vascularization for Tissue Engineering and Regenerative Medicine. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-21056-8.

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Meyer, Ulrich, Jörg Handschel, Hans Peter Wiesmann, and Thomas Meyer, eds. Fundamentals of Tissue Engineering and Regenerative Medicine. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-77755-7.

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Peter, Wiesmann Hans, Handschel Jörg, Meyer Thomas, and SpringerLink (Online service), eds. Fundamentals of Tissue Engineering and Regenerative Medicine. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009.

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Popat, Ketul. Nanotechnology in tissue engineering and regenerative medicine. Boca Raton: CRC Press, 2011.

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Nanotechnology in tissue engineering and regenerative medicine. Boca Raton, FL: CRC Press, 2011.

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1958-, Atala Anthony, ed. Principles of regenerative medicine. Amsterdam: Academic Press, 2008.

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Book chapters on the topic "Tissue engineering. Regenerative Medicine"

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Helsen, Jozef A., and Yannis Missirlis. "Tissue Engineering: Regenerative Medicine." In Biological and Medical Physics, Biomedical Engineering, 269–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12532-4_13.

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Hansda, Anita, Sayan Mukherjee, Krishna Dixit, Santanu Dhara, and Gayatri Mukherjee. "Immunological Perspectives Involved in Tissue Engineering." In Regenerative Medicine, 37–55. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-6008-6_3.

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Engel, Elisabeth, Oscar Castaño, Emiliano Salvagni, Maria Pau Ginebra, and Josep A. Planell. "Biomaterials for Tissue Engineering of Hard Tissues." In Strategies in Regenerative Medicine, 1–42. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-74660-9_3.

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Dadhich, Prabhash, Parveen Kumar, Anirban Roy, and Khalil N. Bitar. "Advances in 3D Printing Technology for Tissue Engineering." In Regenerative Medicine, 181–206. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-6008-6_9.

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Hasirci, Vasif, and Nesrin Hasirci. "Tissue Engineering and Regenerative Medicine." In Fundamentals of Biomaterials, 281–302. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8856-3_18.

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Sundaram, Sumati, Joshua Siewert, Jenna Balestrini, Ashley Gard, Kevin Boehm, Elise Wilcox, and Laura Niklason. "Tissue engineering and regenerative medicine." In Rossi's Principles of Transfusion Medicine, 488–504. Chichester, WestSussex: John Wiley & Sons, Ltd., 2016. http://dx.doi.org/10.1002/9781119013020.ch42.

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Dahman, Yaser. "Tissue Engineering and Regenerative Medicine." In Biomaterials Science and Technology, 235–58. Boca Raton : Taylor & Francis, 2019.: CRC Press, 2019. http://dx.doi.org/10.1201/9780429465345-10.

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Hill, Michael J., Morteza Mahmoudi, and Parisa P. S. S. Abadi. "Nanobiomaterial Advances in Cardiovascular Tissue Engineering." In Cardiovascular Regenerative Medicine, 79–106. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-20047-3_5.

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Varghese, Shyni, and Jennifer H. Elisseeff. "Hydrogels for Musculoskeletal Tissue Engineering." In Polymers for Regenerative Medicine, 95–144. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/12_072.

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Bhaskar, Nitu. "Bioceramic Nanoparticles for Tissue Engineering." In Nanopharmaceuticals in Regenerative Medicine, 95–107. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003153504-6.

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Conference papers on the topic "Tissue engineering. Regenerative Medicine"

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Borenstein, Jeffrey T., and Christopher J. Bettinger. "Engineered nanotopographic structures for applications in tissue engineering and regenerative medicine." In 2009 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Formerly known as LSSA and. IEEE, 2009. http://dx.doi.org/10.1109/lissa.2009.4906699.

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Şenel-Ayaz, H. G., A. Perets, M. Govindaraj, D. Brookstein, and P. I. Lelkes. "Textile-templated electrospun anisotropic scaffolds for tissue engineering and regenerative medicine." In 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010). IEEE, 2010. http://dx.doi.org/10.1109/iembs.2010.5627466.

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Green, David W., and Besim Ben-Nissan. "Biomimetics: Bio-inspired Engineering of Human Tissue Scaffolding for Regenerative Medicine." In In Commemoration of the 1st Asian Biomaterials Congress. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812835758_0023.

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Yu, Claire, Shangting You, Wei Zhu, Bingjie Sun, and Shaochen Chen. "DMD-based rapid 3D bioprinting for precision tissue engineering and regenerative medicine." In Emerging Digital Micromirror Device Based Systems and Applications XII, edited by Benjamin L. Lee and John Ehmke. SPIE, 2020. http://dx.doi.org/10.1117/12.2550340.

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Teo, Ka Yaw, J. Craig Dutton, Frederick Grinnell, and Bumsoo Han. "Effects of Freezing-Induced Cell-Fluid-Matrix Interactions on Cells and Extracellular Matrix of Engineered Tissues." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53407.

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Long-term cryopreservation of functional engineered tissues (ETs) is a key enabling technology for tissue engineering and regenerative medicine. However, a limited understanding of tissue-level biophysical phenomena during freeze/thaw (F/T) and their effects on cells and ECM microstructure poses significant challenges for i) preserving tissue functionality, and ii) controlling highly tissue-type dependent cryopreservation outcomes.
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Chen, Shaochen. "Nano and Microscale Light-based 3D Bioprinting for Tissue Engineering and Regenerative Medicine." In The 7th World Congress on New Technologies. Avestia Publishing, 2021. http://dx.doi.org/10.11159/icnfa21.002.

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Yan, Karen Chang, Pamela Hitscherich, and James Ferrie. "Effects of Process Parameters on Formation of Hybrid Tissue Constructs." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-66430.

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Tissue engineering is a promising aspect of regenerative medicine that is aimed at constructing functional tissues and organs. While progresses in tissue engineering have led successful clinic applications, challenges remain for more complex tissues/organs that require concerted efforts from multiple types of cells. One of the key issues in building replacements for complex tissues/organs is to mimic the organ’s complex natural organization using a mixture of engineered materials and living cells [1]. Electrospinning has shown promise as a technique to create the microenvironment necessary for cell growth and proliferation for tissue engineering applications[2–4], while multiple fabrication methods have been developed to manipulate live cells(e.g. cell printing) [5–7]. To this end, a system integrating polymer electrospinning technique and pressure-driven cell deposition method is currently under development for forming hybrid tissue constructs with living cells and polymers. This study focuses on examining morphology of electrospun fibers as function of processing parameters including working distance and solution flow rate.
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Kubo, H., T. Shioyama, M. Oura, A. Suzuki, T. Ogawa, H. Makino, S. Takeda, et al. "Development of automated 3-dimensional tissue fabrication system Tissue factory - Automated cell isolation from tissue for regenerative medicine." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6609511.

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Pöttler, M., E. Schreiber, S. Dürr, M. Döllinger, and C. Alexiou. "Regenerative Medicine of the vocal fold: Magnetic Tissue Engineering (MTE) using superparamagnetic ironoxide nanoparticles." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1641055.

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Thakare, Ketan, Xingjian Wei, Laura Jerpseth, Zhijian Pei, and Hongmin Qin. "Experimental Investigation of Alginate-Methylcellulose Composition and Printing Direction on Dimensional Accuracy of 3D Printed Constructs." In ASME 2020 15th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/msec2020-8478.

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Abstract Bioprinting technology has a great potential in the fields of tissue engineering and regenerative medicine. In tissue engineering, for a bioprinted tissue to be successful in supporting regeneration of new tissue, it should morphologically mimic the native tissue in vivo. Therefore, the bioprinted tissue needs to be dimensionally accurate. In extrusion-based bioprinting, 3D printing process parameters and bioink properties affect dimensional accuracy of printed constructs. Currently, little information is available on effects of bioink composition and printing direction on dimensional accuracy of 3D printed constructs using alginate:methylcelluolose based bioink. In this study, strands were printed using four compositions of alginate:methylcellulose bioink and two printing directions. The four compositions of alginate:methylcellulose bioink were 1:1.5, 1:2, 1:2.5 and 1:3, and the two printing directions were vertical and horizontal. The statistical analysis of strand width measurement data revealed that while bioink composition has significant effect, printing direction does not affect the strand width of 3D printed constructs at the significance level of 0.05.
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Reports on the topic "Tissue engineering. Regenerative Medicine"

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Research, Gratis. Regenerative Medicine: A Breakthrough in the Branch of Medicine. Gratis Research, November 2020. http://dx.doi.org/10.47496/gr.blog.04.

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Regenerative medicine, being an interdisciplinary field, applies the principle of engineering and life science to promote regeneration. Regenerative medicine supports the treatment of chronic diseases and acute insults
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