Relevant bibliographies by topics / Tissue application

Academic literature on the topic 'Tissue application'

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Published: 14 March 2023

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Journal articles on the topic "Tissue application"

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Feng, Wei, Yoke San Wong, and Dietmar W. Hutmacher. "The Application of Image Processing Software for Tissue Engineering(Cellular & Tissue Engineering)." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2004.1 (2004): 95–96. http://dx.doi.org/10.1299/jsmeapbio.2004.1.95.

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Jing, D., Y. Yi, W. Luo, S. Zhang, Q. Yuan, J. Wang, E. Lachika, Z. Zhao, and H. Zhao. "Tissue Clearing and Its Application to Bone and Dental Tissues." Journal of Dental Research 98, no. 6 (April 22, 2019): 621–31. http://dx.doi.org/10.1177/0022034519844510.

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Opaqueness of animal tissue can be attributed mostly to light absorption and light scattering. In most noncleared tissue samples, confocal images can be acquired at no more than a 100-µm depth. Tissue-clearing techniques have emerged in recent years in the neuroscience field. Many tissue-clearing methods have been developed, and they all follow similar working principles. During the tissue-clearing process, chemical or physical treatments are applied to remove components blocking or scattering the light. Finally, samples are immersed in a designated clearing medium to achieve a uniform refractive index and to gain transparency. Once the transparency is reached, images can be acquired even at several millimeters of depth with high resolution. Tissue clearing has become an essential tool for neuroscientists to investigate the neural connectome or to analyze spatial information of various types of brain cells. Other than neural science research, tissue-clearing techniques also have applications for bone research. Several methods have been developed for clearing bones. Clearing treatment enables 3-dimensional imaging of bones without sectioning and provides important new insights that are difficult or impossible to acquire with conventional approaches. Application of tissue-clearing technique on dental research remains limited. This review will provide an overview of the recent literature related to the methods and application of various tissue-clearing methods. The following aspects will be covered: general principles for the tissue-clearing technique, current available methods for clearing bones and teeth, general principles of 3-dimensional imaging acquisition and data processing, applications of tissue clearing on studying biological processes within bones and teeth, and future directions for 3-dimensional imaging.
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Hollander, J. E., and A. J. Singer. "Application of tissue adhesives." Plastic Surgical Nursing 19, no. 4 (1999): 209. http://dx.doi.org/10.1097/00006527-199919040-00011.

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Un, Umran Tezcan, Seher Topal, Emre Oduncu, and Ulker Bakir Ogutveren. "Treatment of Tissue Paper Wastewater: Application of Electro-Fenton Method." International Journal of Environmental Science and Development 6, no. 6 (2015): 415–18. http://dx.doi.org/10.7763/ijesd.2015.v6.628.

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Dhandayuthapani, Brahatheeswaran, Yasuhiko Yoshida, Toru Maekawa, and D. Sakthi Kumar. "Polymeric Scaffolds in Tissue Engineering Application: A Review." International Journal of Polymer Science 2011 (2011): 1–19. http://dx.doi.org/10.1155/2011/290602.

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Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.
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Pascoal-Faria, Paula, Pedro Castelo Ferreira, Abhishek Datta, Sandra Amado, Carla Moura, and Nuno Alves. "Electrical Stimulation Optimization in Bioreactors for Tissue Engineering Applications." Applied Mechanics and Materials 890 (April 2019): 314–23. http://dx.doi.org/10.4028/www.scientific.net/amm.890.314.

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We review here the current research status on bioreactors for tissue engineering with cell electrical stimulation. Depending on the cell types, electrical stimulation has distinct objectives, in particular being employed both to mimic and enhance the endogenous electricity measured in the natural regeneration of living organisms as well as to mimic strain working conditions for contractible tissues (for instance muscle and cardiac tissues). Understanding the distinct parameters involved in electrical stimulation is crucial to optimize its application. The results presented in the literature and reviewed here reveal that the application of electrical stimulation can be essential for tissue engineering applications.
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Borrella-Andrés, Sergio, Miguel Malo-Urriés, Albert Pérez-Bellmunt, José L. Arias-Buría, Jacobo Rodríguez-Sanz, María Isabel Albarova-Corral, Vanessa González-Rueda, Gracia M. Gallego-Sendarrubias, César Fernández-de-las-Peñas, and Carlos López-de-Celis. "Application of Percutaneous Needle Electrolysis Does Not Elicit Temperature Changes: An In Vitro Cadaveric Study." International Journal of Environmental Research and Public Health 19, no. 23 (November 26, 2022): 15738. http://dx.doi.org/10.3390/ijerph192315738.

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Percutaneous needle electrolysis (PNE) consists of the ultrasound-guided application of a galvanic electrical current through a solid filament needle. One proposed therapeutic mechanism for this intervention is a potential thermal effect. The aim of this study was to investigate if the application of PNE induces changes in temperature in different cadaveric musculoskeletal tissues. A repeated measure experimental cadaveric study was designed with 10 cryopreserved knees (5 men, 5 women). Sterile stainless-steel needles of 40 mm length and 0.30 mm caliber were used in this study. An ultrasound-guided needling puncture was performed in the targeted tissue (patellar tendon, infra-patellar fat, and vastus medialis muscle). Additionally, the tip of the needle was placed next to the thermometer sensor at the minimum possible distance without direct contact with it. The temperature differences before and after different applications were measured. The applications were: three applications for 3 s of 3 mA of intensity (3:3:3) when the tendon was the targeted tissue, three applications for 3 s of 1.5 mA of intensity (1.5:3:3) when the fat or muscle was the targeted tissue, and 24 s of 1 mA of intensity (1:24:1) in all tissues. No statistically significant Group*Time interactions were found in any tissue (tendon: F = 0.571, p = 0.459, ŋ2 = 0.03; fat pad: F = 0.093; p = 0.764, ŋ2 = 0.01; muscle: F = 0.681; p = 0.420, ŋ2 = 0.04). Overall, no changes in temperature were observed between both applications in the tendon (3:3:3 vs. 1:24:1) and fat/muscle (1.5:3:3 vs. 1:24:1) tissues. The application of two different percutaneous needle electrolysis protocols did not produce appreciable thermal changes in the tendon, fat, and muscle tissues of human cadavers. The results from the current cadaver study support that a thermal effect should not be considered as a mechanism of clinical action regardless of the targeted human tissue when applying percutaneous needle electrolysis since no changes in temperature after its application were observed.
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Best, Cameron, Ekene Onwuka, Victoria Pepper, Malik Sams, Jake Breuer, and Christopher Breuer. "Cardiovascular Tissue Engineering: Preclinical Validation to Bedside Application." Physiology 31, no. 1 (January 2016): 7–15. http://dx.doi.org/10.1152/physiol.00018.2015.

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Advancements in biomaterial science and available cell sources have spurred the translation of tissue-engineering technology to the bedside, addressing the pressing clinical demands for replacement cardiovascular tissues. Here, the in vivo status of tissue-engineered blood vessels, heart valves, and myocardium is briefly reviewed, illustrating progress toward a tissue-engineered heart for clinical use.
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TORII, Takahiro, Mitsuo MIYAZAWA, and Isamu KOYAMA. "Application of Shear Stress to Tissue Engineering." Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) 28, no. 2 (2003): 168–70. http://dx.doi.org/10.4030/jjcs1979.28.2_168.

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Varghese, Dr Mekha Grace, Dr Thomas George V., Dr Nebu George Thomas, Dr Alenya Mary Pyas, and Dr Arimboor Maymol Francis. "Marine Based Biomaterials in Dental Regeneration." International Journal of Innovative Research in Medical Science 5, no. 10 (October 3, 2020): 443–48. http://dx.doi.org/10.23958/ijirms/vol05-i10/965.

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The novel approach of tissue engineering aims at regenerating the functional alveolar or periodontal tissues through a series of key events that is modulated by the use of scaffolds, cells and signalling molecules. Many synthetic and natural polymers have been used as tissue engineering constructs so far with varying results in regeneration. Developing a biomaterial to replace the damaged tissue is of paramount importance for effective regeneration. Due to its rich biodiversity, marine environment yields structures with immense potential for biomedical application. These bio molecules offer many applications in cartilage and bone tissue engineering, dental tissue regeneration, wound healing and local drug delivery system. These substances are usually nontoxic, bio compatible and well tolerated by the body, which boost their efficacy for tissue engineering application. In this article, we are trying to brief the various marine based biomaterials used in dental regeneration, their possible sources and clinical applications.
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Dissertations / Theses on the topic "Tissue application"

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Ueda, Yuichiro. "Application of Tissue Engineering with Xenogenic Cells and Tissues for Regenerative Medicine." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147657.

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BERNOCCO, MARCO. "Bioreactor engineering for tissue engineering application." Doctoral thesis, Politecnico di Torino, 2013. http://hdl.handle.net/11583/2513796.

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Lo scopo di questo lavoro di tesi è la caratterizzazione metrologica di un bioreattore con l’intento di aumentare la riproducibilità e l’affidabilità dei processi di Ingegneria tessutale (Tissue Engineering, TE). La Tissue engineering (TE) o ingegneria dei tessuti è la disciplina che studia la comprensione dei principi della crescita dei tessuti, e la loro applicazione per produrre tessuto funzionale per uso clinico o diagnostico. Uno dei principali scopi della TE è l’impiego di tessuti in crescita naturale extracorporea per la medicina rigenerativa, in altre parole lo sviluppo di strategie terapeutiche mirate alla sostituzione, riparazione, manutenzione e/o il miglioramento della funzione dei tessuti. L’ingegneria dei tessuti è caratterizzata da una grande interdisciplinarità che prevede la collaborazione di figure professionali con competenze molto differenti tra loro, quali biologi, chimici, fisici, matematici, ingegneri. L’obiettivo è il progetto di un bioreattore che sia affidabile e controllabile per seguire l’evoluzione del processo. Questo deve essere eseguito applicando metodi metrologici allo studio del processo. La metrologia permette di poter quantificare l’incertezza di un fenomeno quindi di determinare la proprietà di un fenomeno, corpo o sostanza, che può essere distinta qualitativamente e determinata quantitativamente. Le fonti d’incertezza che caratterizzano l’incertezza finale o composta è legata: alla mancanza di conoscenza e alla variabilità del sistema e prevede strategie differenti per la loro gestione. La mancanza di conoscenza e può essere ridotta migliorando le informazioni sul sistema in esame, mentre la variabilità del sistema sotto studio, può essere gestita riducendo degli scenari presi in considerazione o definendo più precisamente il sistema studiato.
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Yuan, Tai-Yi. "Innovative Methods to Determine Material Properties of Cartilaginous Tissues and Application for Tissue Engineering." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/607.

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Low back pain is one of the major health concerns in the US. It affects up to 80% of the population at some time during their lives. It not only causes discomfort to patients and affects their physical ability but also has a huge economic impact on society. Although the cause of low back pain is still poorly understood, it is implicated that degeneration of the intervertebral disc is the primary factor. Currently, researchers are trying to use tissue engineering approaches to develop new treatments capable of removing the degenerated disk and replacing it with a biological substitute. However, to create such a biological substitute, we need to first understand the structure-function relationship of the tissue. Only when we understand the function of the tissue, can we begin creating biological substitutes. While culturing a biological substitute, we also need methods to determine how the substitute responds to its environment. At present, there are many different types of bioreactors developed for cartilaginous tissues. However, there is a lack of a system that can detect the chemical, electrical and mechanical response noninvasively with control feedback in real-time. It is hard to provide the optimal culture environment to the substitute without knowing its response in real-time. The objective of this dissertation is to develop new methods to investigate the transport property, oxygen consumption rate and mechano-electrochemical and mechanical properties of the tissue. Because cells are responsible for the tissue health, it is necessary to understand how they can obtain nutrients under different environments, e.g. under different loading condition. In addition, with the use of a bioreactor with the capability of detecting the real-time response combined with a feedback control system, we can provide the most favorable conditions for tissue or biological substitutes to grow. The new measurement methods developed in this dissertation can contribute to further understanding the function of the tissue. The methods outlined in this dissertation can also provide new tools for future tissue engineering applications. Moreover, the findings in this dissertation can provide information for developing a more comprehensive theoretical model to elucidate the etiology of disc degeneration.
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Halili, Ndreu Albana. "Collagen-based Meniscus Tissue Engineering: Design And Application." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613451/index.pdf.

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Meniscus is a wedge shaped structure, with a convex base attached to a flat tibial surface, and with a concave femoral surface, on which femur and tibia articulate. It has several functions including joint lubrication, shock absorption, load transmission and joint stability. Various methods were tried to treat meniscal tears but each has its own drawbacks. Tissue engineering seems to be a promising solution that avoids all the problems associated with the other approaches. In this study, a three dimensional (3D) collagen-based structure was prepared by tissue engineering to mimic the natural human meniscus. Three different foams prepared under different conditions were combined and nano/microfibrous layers were placed in between them. To mimic the properties of the natural tissue, the top layer was composed of collagen-chondroitin sulfate-hyaluronic acid (Coll-CS-HA) prepared by freezing at -20º
C followed by lyophilization. The middle and bottom layers were made with just collagen after freezing at -20º
C and -80º
C, respectively and lyophilization. Aligned nano/microfibers were prepared using collagen-poly(L-lactic-co-glycolic acid (Coll-PLGA). Various crosslinking procedures such as 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS), genipin (GP), glutaraldehyde (GLU) either alone or in combination with dehydrothermal treatment (DHT) were used and based on both compressive and tensile properties, the best crosslinker was chosen to be DHT+EDC/NHS. Mechanical properties (compressive, tensile and shear) of the dry foams and the final 3D construct were evaluated. The highest mechanical properties were obtained with the 3D construct. Then all these foams and the 3D construct were seeded with human fibrochondrocytes to study the cell behavior such as attachment, proliferation, and extracellular matrix (ECM) and glucosaminoglycan (GAG) production. Furthermore, the influence of cell seeding on the compressive properties of wet individual foams and the 3D construct was observed. As expected, the highest cell proliferation and compressive properties were obtained with the 3D construct. Finally, the 3D constructs, seeded with fibrochondrocytes, were implanted in New Zealand rabbits after meniscectomy. The initial microscopical examination show that the 3D construct has a significant potential as a meniscus substitute.
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Walsh, Pamela Judith. "Natural calcium phosphate ceramics for tissue engineering application." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486236.

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There is a great need for new bone graft materials. Bone related problems have increased considerably over the last few decades, owing to an ageing populate and the associated prevalence of bone disease. The traditional method of grafting to bridge bone defects are still widely used, despite a wide selection of new synthetic alternatives materials becoming available. These tend to lack the physical properties, such as porosity, interconnective and mechanical strength required for bone repair. Coral derived CaP ceramics have shown good potential, as substitute materials, offering the desirable physiochemical characteristics required for bone repair. This study investigated the development of a bioceramic from marine origins for use in bone tissue applications. Algae species were specifically selected to take account of their fast growth rate and aquaculture potential, which would minimise the environmental impact of harvesting. The conversion of alga was achieved through a novel technique, involving well controlled thermal processing followed by low pressure temperature hydrothermal synthesis technique. Using this technique, the original skeletal morphology of the alga was retained throughout processing. The resultant material was found to be a tri-phasic ceramic, with a > 90% composition of HA. Calcite and 13-TCP were the other two phases identified in the material. Cell studies confirmed the material to have good biocompatibility. A preliminary scaffold fabrication study incorporated the CaP material into a polymeric scaffold. The study found that the CaP material was robust and capable of withstanding rigorous processing. The work presented in this thesis indicates that this novel process is capable of synthesising a reproducible CaP material, which possesses suitable physiochemical properties for use in bone tissue engineering applications.
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Aarvold, Alexander. "Bone tissue engineering : experimental strategies and clinical application." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/362817/.

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Skeletal stem cell based therapies offer tremendous potential for regeneration of a patient's bone. With the demo graphics of an ageing population, the demand for skeletal reconstruction to replace lost or damaged bone is expanding dramatically. Novel bone tissue engineering techniques offer the opportunity to push the boundaries of bone regeneration, yet few strategies have been translated to clinical practice. This thesis aims to explore novel bone regeneration strategies in vitro and in vivo, and details the clinical application of those techniques. The effects of skeletal stem cells, growth factors and material properties on osteogenesis of bone tissue engineering constructs were explored: • Skeletal stem cells and human fibronectin were shown to augment the biomechanical characteristics of impacted allograft. • Alteration of porosity in a synthetic ceramic scaffold had an effect on osteogenesis. • Innovative technology for enriching the skeletal stem cell fraction from aspirated bone marrow was successfully trialled on bone marrow from an elderly COhOli of . patients, reaching a therapeutic cellular concentration. • A pathological role for osteogenic cells was demonstrated in unicameral bone cysts, with up-regulation of RANI
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Schill, Markus A. "Biomechanical soft tissue modeling techniques, implementation and application /." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10605020.

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Gagliardi, Davide. "Le paradigme de la Matryoshka : Application à l'homogénéisation stochastique des propriétés matérielles du tissu osseux." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC1115/document.

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Non seulement la structure hiérarchisée du tissu osseux mais aussi son hétérogénéité, son anisotropie et les incertitudes expérimentales de mesures liées aux matériaux vivants rendent en pratique impossible la définition d'un modèle déterministe fiable de ses propriétés matérielles. Dans une démarche d'aide au diagnostic clinique, l'objectif de cette thèse est de développer une modélisation robuste desdites propriétés à l'échelle de l'organe en intégrant l'incertitude expérimentale de mesures.Pour ce-faire, nous avons développé un modèle multi-échelle stochastique basé sur le principe du maximum d'entropie et des méthodes d’homogénéisation en champs moyens (micromécanique) qui s'est montré capable de prédire les propriétés matérielles du tissu osseux à l'échelle de l'organe en prenant en compte les incertitudes expérimentales de données issues de l’imagerie. Dans la perspective d'identifier le mécanisme de propagation de l’incertitude à travers le modèle multi-échelle, plusieurs versions de ce modèle ont été analysées.Le modèle principal utilise comme variables primaires la fraction volumique des constituants essentiels (le minéral, l'eau et le collagène) pour lesquelles une discussion est proposée échelle par échelle en examinant leur effet sur les propriétés effectives à chaque échelle. Cette description est à l’image d'une matryoshka, plus communément appelée poupée russe, via l’aspect multi-échelle. Chaque matryoshka est une série de poupées de tailles décroissantes placées les unes à l'intérieur des autres. Grâce à cette analyse, cette version du modèle a pu être liée de façon directe aux mesures expérimentales issues de l’imagerie médicale que sont la densité minérale du tissu (TMD) et la porosité haversienne (HP) de l'os cortical lors d’une calibration à l’échelle millimétrique. Cette version a été validée en utilisant plusieurs méthodes numériques telles que la méthode aux éléments finis et la méthode de la transformée de Fourier rapide. On a ainsi pu non seulement évaluer la précision de la méthode proposée mais aussi analyser le processus de transfert d'incertitudes entre les échelles.Enfin, la modélisation stochastique de l'os cortical a été complétée en introduisant des champs de tenseurs d’élasticité des matériaux impliqués dans le processus d’homogénéisation pour l’obtention des propriétés effectives. L’incertitude est introduite via un tenseur aléatoire et se propage spatialement en respectant des longueurs de corrélation et en une suite de réalisations. Ici encore, cette approche peut être vue comme une déclinaison des matryoshka via les champs de tenseurs d’élasticité qui se déclinent dans la procédure stochastique
The hierarchical structure of bone tissues, as well as the heterogeneity and anisotropy of its physical properties and the uncertainty on in vivo experimental measures make it impossible to establish a deterministic reliable model of bone mechanical properties. Aiming at providing a valuable aide to diagnostics in orthopaedic, the purpose of this thesis is to develop a robust mechanical model able to account for the experimental uncertainty.Therefore we developed a multi-scale stochastic model, based on continuum micromechanics and maximum entropy principle which has proved effective predicting the heterogeneous and anisotropic elastic properties of bone tissue at the organ scale accounting for experimental uncertainty affecting image-based input data.Aiming to clarify the mechanism of propagation of these uncertainties through the chosen principal multi-scale model, others versions have been analyzed. First, the principal model, which uses the volume fractions of the essential constituents (mineral, water, collagen), as primary variables, has been analyzed scale-by-scale (mineral foam, ultra-structure, cortical bone). The effect of the chosen homogenization methods and volume fractions on the resulting composites (as layers of a random Matryoshka) have been discussed. Thanks to this analysis, this model has been simplified and relied directly to the measures straightly accessible form medical imaging of the bone: the tissue mineral density (TMD) and the haversian porosity (HP) and their calibration at millimeter scale. This version of the stochastic model, proved to be as accurate as the proceeding one and, more effective in the description of the bone.Finally, the stochastic model of bone has been completed with the direct modeling of the elastic tensors of the involved materials. For this purpose, the random matrix theory has been applied. This theory can be seen as another declination of the Matryoshka paradigm. In this case, the uncertainty on the random tensor propagate from the inside (random germ) to outside (each layer of random matrix) through a suitable sequence of nonlinear operations. Thanks to the proposed decomposition, at once, the isotropic material class of the resulting material and his spatial variability has been included in the model
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Åkesson, Elisabet. "Human spinal cord transplantation : experimental and clinical application /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4322-2/.

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Heus, Redha. "Approches virtuelles dédiées à la technologie des puces à tissus "Tissue MicroArrays " TMA : Application à l'étude de la transformation tumorale du tissu colorectal." Phd thesis, Université Joseph Fourier (Grenoble), 2009. http://tel.archives-ouvertes.fr/tel-00429056.

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La technique récente des puces à tissus " Tissue Micro Arrays " TMA apparaît comme un moyen indispensable d'investigation pour la validation des profils d'expression des marqueurs tumoraux en relation avec la dynamique de l'architecture tissulaire lors de la transformation tumorale. Brièvement, cette technologie consiste à regrouper, dans un seul bloc de paraffine, plusieurs centaines de petits échantillons tissulaires sous forme de carottes cylindriques prélevées à partir de différents blocs de biopsies classiques. Le sujet de thèse s'intéresse aux différents aspects de traitement d'images et de contrôle qualité liés à la technologie TMA. Les travaux de thèse sont réalisés selon deux grands axes qui retracent l'enchaînement chronologique des opérations : conception des blocs TMA, puis analyse automatique des coupes TMA. Dans un premier temps, le concept de TMA virtuel est introduit pour simuler les protocoles de prélèvement de carottes afin d'évaluer la technologie TMA. En deuxième temps, une modélisation originale de la couleur associée au diagramme de chromaticité xy, est proposée pour la détection automatique des marqueurs tumoraux au niveau des coupes TMA. Le concept de sociologie cellulaire, modélisé par le diagramme de Voronoï, est finalement adopté pour illustrer la dynamique de la distribution spatiale des cellules cancéreuses au cours de la transformation tumorale. Les méthodes développées sont appliquées à l'étude des marqueurs tumoraux du cancer colorectal.
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Books on the topic "Tissue application"

1

Ebner, Maria. Connective tissue manipulations: Theory and therapeutic application. 3rd ed. Malabar, Fla: R.E. Krieger Pub. Co., 1985.

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Afaq, Sarah, Arshi Malik, and Mohammed Tarique, eds. Application of Nanoparticles in Tissue Engineering. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6198-3.

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Horan, Imelda. Tissue culture of roses and its application in rose breeding. London: University of East London, 1994.

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Jona, Roberto. Tissue culture of selected tropical fruit plants: A handbook on the application of tissue culture to plant propagation. Rome: Food and Agriculture Organization of the United Nations, 1987.

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Imani, Jafargholi. Plant Cell and Tissue Culture - A Tool in Biotechnology: Basics and Application. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2009.

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Watts, David L. Trace elements and other essential nutrients: Clinical application of tissue mineral analysis. [S.L: s.n.], 1995.

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Stephan, Klaus, ed. Microdialysis--monitoring tissue chemistry in intensive care medicine: Experimental results and clinical application of biochemical tissue monitoring in critical illness. Lengerich: Pabst Science Publ., 2004.

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Nhut, Duong Tan, Hoang Thanh Tung, and Edward Chee-Tak YEUNG, eds. Plant Tissue Culture: New Techniques and Application in Horticultural Species of Tropical Region. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6498-4.

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J, Marangos Paul, Campbell Iain C, and Cohen Robert M, eds. Neuronal and glial proteins: Structure, function, and clinical application. San Diego: Academic Press, 1988.

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1821-1898, Schüssler Wilhelm Heinrich, and Dewey, Willis A. (Willis Alonzo), 1858-1938, eds. The twelve tissue remedies of Schus̈sler, comprising the theory, therapeutic application, materia medica & a complete repertory of tissue remedies: Homoeopathically and bio-chemically considered. 6th ed. New Delhi: B. Jain, 1989.

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Book chapters on the topic "Tissue application"

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Sora and Viroj Wiwanitkit. "Tissue Engineering and Application in Tropical Medicine." In Tissue Engineering, 137–58. Boca Raton: Apple Academic Press, 2022. http://dx.doi.org/10.1201/9781003180531-4.

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Maurel, Walter, Daniel Thalmann, Yin Wu, and Nadia Magnenat Thalmann. "Application Perspectives." In Biomechanical Models for Soft Tissue Simulation, 141–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-03589-4_6.

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Goldberg, Victor M. "Biology of Bone Allograft and Clinical Application." In Musculoskeletal Tissue Regeneration, 81–92. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-239-7_5.

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Mahendiran, Balaji, Shalini Muthusamy, Sowndarya Sampath, S. N. Jaisankar, and Gopal Shankar Krishnakumar. "Nanocelluloses for Tissue Engineering Application." In Handbook of Nanocelluloses, 543–72. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-89621-8_37.

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Mahendiran, Balaji, Shalini Muthusamy, Sowndarya Sampath, S. N. Jaisankar, and Gopal Shankar Krishnakumar. "Nanocelluloses for Tissue Engineering Application." In Handbook of Nanocelluloses, 1–30. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62976-2_37-1.

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Miller, Karol, Adam Wittek, Grand Joldes, Jiajie Ma, and Ben Jamin Zwick. "Computational Biomechanics of the Brain; Application to Neuroimage Registration." In Neural Tissue Biomechanics, 135–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/8415_2011_80.

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Taylan, Enes, and Kutluk Oktay. "Application of Decellularized Tissue Scaffolds in Ovarian Tissue Transplantation." In Methods in Molecular Biology, 177–81. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/7651_2017_35.

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Thijssen, J. M. "Multiparameter Ultrasonic Tissue Characterization and Image Processing: from Experiment to Clinical Application." In Ultrasonic Tissue Characterization, 75–94. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-68382-7_6.

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Nalini Ranganathan, A. Mugeshwaran, R. Joseph Bensingh, M. Abdul Kader, and Sanjay K. Nayak. "Biopolymeric Scaffolds for Tissue Engineering Application." In Biomedical Engineering and its Applications in Healthcare, 249–74. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3705-5_11.

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Nagarajan, Sakthivel, S. Narayana Kalkura, Sebastien Balme, Celine Pochat Bohatier, Philippe Miele, and Mikhael Bechelany. "Nanofibrous Scaffolds for Tissue Engineering Application." In Handbook of Nanofibers, 665–91. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-53655-2_30.

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Conference papers on the topic "Tissue application"

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Krebs, Dieter, Volkhard Abraham, Stephan Schmidt, Stefan B. Spaniol, Peter Nothof, Wolfgang Ertmer, and Dagmar Kobe. "Calculation of isofluence contours for PDT application." In Laser-Tissue Interaction V. SPIE, 1994. http://dx.doi.org/10.1117/12.182941.

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Tian, Zhaobing. "Mechanism and clinical application of laser acupuncture." In Laser-Tissue Interaction V. SPIE, 1994. http://dx.doi.org/10.1117/12.182965.

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Li, Dongyu, Dan Ding, Ben Zhong Tang, Junle Qu, Jun Qian, and Dan Zhu. "AIEgen-assisted STED nanoscopy and its application for super-resolved cellular visualization (Conference Presentation)." In Tissue Optics and Photonics, edited by Zeev Zalevsky, Valery V. Tuchin, and Walter C. Blondel. SPIE, 2020. http://dx.doi.org/10.1117/12.2566129.

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Tuchina, Daria K., Olga A. Sindeeva, Alexander P. Savitsky, Alexei A. Bogdanov, and Valery V. Tuchin. "In vivo application of magnetic resonance imaging contrast agents for tissue optical clearing (Conference Presentation)." In Tissue Optics and Photonics, edited by Zeev Zalevsky, Valery V. Tuchin, and Walter C. Blondel. SPIE, 2020. http://dx.doi.org/10.1117/12.2557365.

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Akilbekova, Dana, Talgat Yakupov, Vyacheslav Ogay, Bauyrzhan Umbayev, Vladislav V. Yakovlev, and Zhandos N. Utegulov. "Brillouin light scattering spectroscopy for tissue engineering application." In Optical Elastography and Tissue Biomechanics V, edited by Kirill V. Larin and David D. Sampson. SPIE, 2018. http://dx.doi.org/10.1117/12.2289923.

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Mehari, Fanuel, Bastian Geißler, Maximilian Rohde, Florian Klämpfl, Florian Stelzle, and Michael Schmidt. "Laser-induced Breakdown Spectroscopy (LIBS) based tissue type mapping of ex-vivo soft tissues - A prospect for tissue specific Laser surgery." In Bio-Optics: Design and Application. Washington, D.C.: OSA, 2017. http://dx.doi.org/10.1364/boda.2017.js1a.2.

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Floume, Timmy, Richard R. A. Syms, Ara W. Darzi, and George B. Hanna. "Broadband transmission spectroscopy in tissue: application to radiofrequency tissue fusion." In SPIE Europe Optics + Optoelectronics, edited by Francesco Baldini, Jiri Homola, and Robert A. Lieberman. SPIE, 2009. http://dx.doi.org/10.1117/12.823091.

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So, Peter T. C. "The application of interferometric imaging in quantitative mechanobiology (Conference Presentation)." In Optical Elastography and Tissue Biomechanics VI, edited by Kirill V. Larin and Giuliano Scarcelli. SPIE, 2019. http://dx.doi.org/10.1117/12.2516343.

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Kandurova, Ksenia Y., Nadezhda Golubova, Vadim Prizemin, Dmitry Sumin, Nikita Adamenkov, Vladimir Shabalin, Andrian V. Mamoshin, and Elena V. Potapova. "The application of the multimodal approach for studying optical properties of bile in obstructive jaundice." In Tissue Optics and Photonics II, edited by Zeev Zalevsky, Valery V. Tuchin, and Walter C. Blondel. SPIE, 2022. http://dx.doi.org/10.1117/12.2621289.

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Botonjic, Edita, and C. Steven Fawcett. "Near-infrared application for tissue identification." In Optics East 2006, edited by Brian M. Cullum and J. Chance Carter. SPIE, 2006. http://dx.doi.org/10.1117/12.686308.

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Reports on the topic "Tissue application"

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Zhang, Yuhao, Wenheng Zhao, Liyang Jia, Nan Xu, Yan Xiao, and Qiyan Li. The application of stem cells in tissue engineering for periodontal defects in randomized controlled trial: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0036.

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WANG, MIN, Sheng Chen, Changqing Zhong, Tao Zhang, Yongxing Xu, Hongyuan Guo, Xiaoying Wang, Shuai Zhang, Yan Chen, and Lianyong Li. Diagnosis using artificial intelligence based on the endocytoscopic observation of the gastrointestinal tumours: a systematic review and meta-analysis. InPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2023. http://dx.doi.org/10.37766/inplasy2023.2.0096.

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Review question / Objective: With the development of endoscopic techniques, several diagnostic endoscopy methods are available for the diagnosis of malignant lesions, including magnified pigmented endoscopy and narrow band imaging (NBI).The main goal of endoscopy is to achieve the real-time diagnostic evaluation of the tissue, allowing an accurate assessment comparable to histopathological diagnosis based on structural and cellular heterogeneity to significantly improve the diagnostic rate for cancerous tissues. Endocytoscopy (ECS) is based on ultrahigh magnification endoscopy and has been applied to endoscopy to achieve microscopic observation of gastrointestinal (GI) cells through tissue staining, thus allowing the differentiation of cancerous and noncancerous tissues in real time.To date, ECS observation has been applied to the diagnosis of oesophageal, gastric and colorectal tumours and has shown high sensitivity and specificity.Despite the highly accurate diagnostic capability of this method, the interpretation of the results is highly dependent on the operator's skill level, and it is difficult to train all endoscopists to master all methods quickly. Artificial intelligence (AI)-assisted diagnostic systems have been widely recognized for their high sensitivity and specificity in the diagnosis of GI tumours under general endoscopy. Few studies have explored on ECS for endoscopic tumour identification, and even fewer have explored ECS-based AI in the endoscopic identification of GI tumours, all of which have reached different conclusions. Therefore, we aimed to investigate the value of ECS-based AI in detecting GI tumour to provide evidence for its clinical application.
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Kumar, Pankaj. Exploring the Presence of microDNAs in Prostate Cancer Cell Lines, Tissue, and Sera of Prostate Cancer Patients and its Possible Application as Biomarker. Fort Belvoir, VA: Defense Technical Information Center, August 2014. http://dx.doi.org/10.21236/ada611607.

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Kumar, Pankaj. Exploring the Presence of microDNAs in Prostate Cancer Cell Lines, Tissue, and Sera of Prostate Cancer Patients and its Possible Application as Biomarker. Fort Belvoir, VA: Defense Technical Information Center, April 2016. http://dx.doi.org/10.21236/ada637015.

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Pesis, Edna, and Mikal Saltveit. Postharvest Delay of Fruit Ripening by Metabolites of Anaerobic Respiration: Acetaldehyde and Ethanol. United States Department of Agriculture, October 1995. http://dx.doi.org/10.32747/1995.7604923.bard.

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The use of pretreatments for 24 h prior to storage, under anaerobic condtions, or in the presence of the natural metabolic products, acetaldehyde (AA) and ethanol, to delay fruit ripening, was found to be effective with several climacteric fruits, among them avocado, mango, peach and tomato. The delay in ripening of avocado, peach and tomato was accompanied by inhibition of ethylene production and of fruit softening. The maintenance of fruit firmness was associated with a decrease in the activities of cell-wall-degrading enzymes, including endoglucanases (Cx), polygalacturonases (PG) and b-galactosidases. In peaches the AA- and N2-treated fruits were firmer after 3 weeks storage and contained higher amount of insoluble pectin than untreated controls. We showed that AA vapors are able to inhibit ripening, ethylene production and ethylene induction in the presence of 1-amino-cyclopropane-1-carboxylic acid (ADD) in avocado and mango tissue. Ethylene induced by ACC is taken as an indicator of ACC oxidase activity. ACC oxidase activity in AA-treated avocado fruit was much lower than in the untreated fruit. In carnation flowers very little ethylene was produced by ethanol-treated flowers, and the normal increases in ACC content and ACC oxidase activity were also suppressed. Using kinetic studies and inhibitors of alcohol dehydrogenase (ADH), we showed that AA, not ethanol, was the active molecule in inhibiting ripening of tomato fruit. Application of anaerobiosis or anaerobic metabolites was effective in reduction of chilling injury (CI) in various plant tissues. Pretreatment with a low-O2 atmosphere reduced CI symptoms in avocado; this effect was associated with higher content of the free sylfhydryl (SH) group, and induction of the detoxification enzymes, catalase and peroxidase. Application of AA maintained firmer and brighter pulp tissue (non-oxidative), which was associated with higher free SH content, lower ethylene and ACC oxidase activities, and higher activities of catalase and peroxidase. Ethanol was found to reduce CI in other plant tissue. In roots of 24-h-old germinated cucumber seeds, exposure to 0.4-M ethanol shock for 4 h reduced chilling-induced ion leakage. In cucumber cotyledons it appears that alcohols may reduce CI by inducing stomata closure. In cotyledon discs held in N2 at 10C for 1 day, there accumulated sufficient endogenously synthesized ethanol to confer tolerance to chilling at 2.5C for 5 days.
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Shani, Uri, Lynn Dudley, Alon Ben-Gal, Menachem Moshelion, and Yajun Wu. Root Conductance, Root-soil Interface Water Potential, Water and Ion Channel Function, and Tissue Expression Profile as Affected by Environmental Conditions. United States Department of Agriculture, October 2007. http://dx.doi.org/10.32747/2007.7592119.bard.

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Constraints on water resources and the environment necessitate more efficient use of water. The key to efficient management is an understanding of the physical and physiological processes occurring in the soil-root hydraulic continuum.While both soil and plant leaf water potentials are well understood, modeled and measured, the root-soil interface where actual uptake processes occur has not been sufficiently studied. The water potential at the root-soil interface (yᵣₒₒₜ), determined by environmental conditions and by soil and plant hydraulic properties, serves as a boundary value in soil and plant uptake equations. In this work, we propose to 1) refine and implement a method for measuring yᵣₒₒₜ; 2) measure yᵣₒₒₜ, water uptake and root hydraulic conductivity for wild type tomato and Arabidopsis under varied q, K⁺, Na⁺ and Cl⁻ levels in the root zone; 3) verify the role of MIPs and ion channels response to q, K⁺ and Na⁺ levels in Arabidopsis and tomato; 4) study the relationships between yᵣₒₒₜ and root hydraulic conductivity for various crops representing important botanical and agricultural species, under conditions of varying soil types, water contents and salinity; and 5) integrate the above to water uptake term(s) to be implemented in models. We have made significant progress toward establishing the efficacy of the emittensiometer and on the molecular biology studies. We have added an additional method for measuring ψᵣₒₒₜ. High-frequency water application through the water source while the plant emerges and becomes established encourages roots to develop towards and into the water source itself. The yᵣₒₒₜ and yₛₒᵢₗ values reflected wetting and drying processes in the rhizosphere and in the bulk soil. Thus, yᵣₒₒₜ can be manipulated by changing irrigation level and frequency. An important and surprising finding resulting from the current research is the obtained yᵣₒₒₜ value. The yᵣₒₒₜ measured using the three different methods: emittensiometer, micro-tensiometer and MRI imaging in both sunflower, tomato and corn plants fell in the same range and were higher by one to three orders of magnitude from the values of -600 to -15,000 cm suggested in the literature. We have added additional information on the regulation of aquaporins and transporters at the transcript and protein levels, particularly under stress. Our preliminary results show that overexpression of one aquaporin gene in tomato dramatically increases its transpiration level (unpublished results). Based on this information, we started screening mutants for other aquaporin genes. During the feasibility testing year, we identified homozygous mutants for eight aquaporin genes, including six mutants for five of the PIP2 genes. Including the homozygous mutants directly available at the ABRC seed stock center, we now have mutants for 11 of the 19 aquaporin genes of interest. Currently, we are screening mutants for other aquaporin genes and ion transporter genes. Understanding plant water uptake under stress is essential for the further advancement of molecular plant stress tolerance work as well as for efficient use of water in agriculture. Virtually all of Israel’s agriculture and about 40% of US agriculture is made possible by irrigation. Both countries face increasing risk of water shortages as urban requirements grow. Both countries will have to find methods of protecting the soil resource while conserving water resources—goals that appear to be in direct conflict. The climate-plant-soil-water system is nonlinear with many feedback mechanisms. Conceptual plant uptake and growth models and mechanism-based computer-simulation models will be valuable tools in developing irrigation regimes and methods that maximize the efficiency of agricultural water. This proposal will contribute to the development of these models by providing critical information on water extraction by the plant that will result in improved predictions of both water requirements and crop yields. Plant water use and plant response to environmental conditions cannot possibly be understood by using the tools and language of a single scientific discipline. This proposal links the disciplines of soil physics and soil physical chemistry with plant physiology and molecular biology in order to correctly treat and understand the soil-plant interface in terms of integrated comprehension. Results from the project will contribute to a mechanistic understanding of the SPAC and will inspire continued multidisciplinary research.
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Lichter, Amnon, David Obenland, Nirit Bernstein, Jennifer Hashim, and Joseph Smilanick. The role of potassium in quality of grapes after harvest. United States Department of Agriculture, October 2015. http://dx.doi.org/10.32747/2015.7597914.bard.

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Objectives: The objectives of the proposal were to study how potassium (K) enters the berry and in what tissues it accumulates, to determine what is the sensitive phenological stage that is responsive to K, to study the influence of K on sugar translocation, to determine if K has effects on expression of genes in source and sink organs and to study applied aspects of the responses to K at the vineyard level. During the research it was realized that K acts externally so a major part of the original objectives had to be deserted and new ones, i.e. the role of K in enhancing water loss from the berry, had to be developed. In addition, the US partners developed practical objectives of understanding the interaction of K application and water deficit as well as application of growth regulators. Background: In our preliminary data we showed that application of K at mid-ripening enhanced sugar accumulation of table grapes. This finding is of major implications to both early and late harvested grapes and it was essential to understand the mode of action of this treatment. Our major hypothesis was that K enters the berry and by that increases sugar translocation into the berry. In addition it was important to cover practical issues of the application which may influence its efficacy and its reproducibility. Conclusions: The major conclusion from the research was that our initial hypothesis was wrong. Mineral analysis of pulp tissue indicated that upon application of K there was a significant increase in most of the major minerals. Subsequently, we developed a new hypothesis that K acts by increasing the water loss from the berry. In vitro studies of K-treated berries corroborated this hypothesis showing greater weight-loss of treated berries. This was not necessarily expressed in the vineyard as in some experiments berry weight remained unchanged, suggesting that the vine compensated for the enhanced water loss. Importantly, we also discovered that the efficacy of different K salts was strongly correlated to the pH of the salt solution: basic K salts had better efficacy than neutral or acidic salts and modifying the pH of the same salt changed its efficacy. It was therefore suggested that K changes the properties of the cuticle making it more susceptible to water loss. Of the practical aspects it was found that application of K to the clusters was sufficient to trigger its affect and that dual application of K had a stronger effect than single application. With regard to timing, it was realized that application of K after veraison was affective and the berries responded also when ripe. While the effect of K application was significant at harvest, it was mostly insignificant one week after application, suggesting that prolonged exposure to K was required. Implications: The scientific implications of the study are that the external mineral composition of the berry may have a significant role in sugar accumulation and that water loss may have an important role in sugar accumulation in grapes. It is not entirely clear how K modulates the cuticle but according to the literature its incorporation into the cuticle may increase its polarity and facilitate generation of "water bridges" between the flesh and the environment. The practical implications of this study are very significant because realizing the mode of action of K can facilitate a much more efficient application strategy. For example, it can be understood that sprays must be directed to the clusters rather than the whole vines and it can be predicted that the length of exposure is important. Also, by increasing the pH of simple K salts, the efficacy of the treatment can be enhanced, saving in the costs of the treatment. Finally, the ability of grape growers to apply K in a safe and knowledgeable way can have significant impact on the length of the season of early grape cultivars and improve the flavor of high grape yields which may otherwise have compromised sugar levels.
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Wolf, Shmuel, and William J. Lucas. Involvement of the TMV-MP in the Control of Carbon Metabolism and Partitioning in Transgenic Plants. United States Department of Agriculture, October 1999. http://dx.doi.org/10.32747/1999.7570560.bard.

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The function of the 30-kilodalton movement protein (MP) of tobacco mosaic virus (TMV) is to facilitate cell-to-cell movement of viral progeny in infected plants. Our earlier findings have indicated that this protein has a direct effect on plasmodesmal function. In addition, these studies demonstrated that constitutive expression of the TMV MP gene (under the control of the CaMV 35S promoter) in transgenic tobacco plants significantly affects carbon metabolism in source leaves and alters the biomass distribution between the various plant organs. The long-term goal of the proposed research was to better understand the factors controlling carbon translocation in plants. The specific objectives were: A) To introduce into tobacco and potato plants a virally-encoded (TMV-MP) gene that affects plasmodesmal functioning and photosynthate partitioning under tissue-specific promoters. B) To introduce into tobacco and potato plants the TMV-MP gene under the control of promoters which are tightly repressed by the Tn10-encoded Tet repressor, to enable the expression of the protein by external application of tetracycline. C) To explore the mechanism by which the TMV-MP interacts with the endogenous control o~ carbon allocation. Data obtained in our previous project together with the results of this current study established that the TMV-MP has pleiotropic effects when expressed in transgenic tobacco plants. In addition to its ability to increase the plasmodesmal size exclusion limit, it alters carbohydrate metabolism in source leaves and dry matter partitioning between the various plant organs, Expression of the TMV-MP in various tissues of transgenic potato plants indicated that sugars and starch levels in source leaves are reduced below those of control plants when the TMV-MP is expressed in green tissue only. However, when the TMV-MP was expressed predominantly in PP and CC, sugar and starch levels were raised above those of control plants. Perhaps the most significant result obtained from experiments performed on transgenic potato plants was the discovery that the influence of the TMV-MP on carbohydrate allocation within source leaves was under developmental control and was exerted only during tuber development. The complexity of the mode by which the TMV-MP exerts its effect on the process of carbohydrate allocation was further demonstrated when transgenic tobacco plants were subjected to environmental stresses such as drought stress and nutrients deficiencies, Collectively, these studies indicated that the influence of the TMV-MP on carbon allocation L the result of protein-protein interaction within the source tissue. Based on these results, together with the findings that plasmodesmata potentiate the cell-to-cell trafficking of viral and endogenous proteins and nucleoproteins complexes, we developed the theme that at the whole plant level, the phloem serves as an information superhighway. Such a long-distance communication system may utilize a new class of signaling molecules (proteins and/or RNA) to co-ordinate photosynthesis and carbon/nitrogen metabolism in source leaves with the complex growth requirements of the plant under the prevailing environmental conditions. The discovery that expression of viral MP in plants can induce precise changes in carbon metabolism and photoassimilate allocation, now provide a conceptual foundation for future studies aimed at elucidating the communication network responsible for integrating photosynthetic productivity with resource allocation at the whole-plant level. Such information will surely provide an understanding of how plants coordinate the essential physiological functions performed by distantly-separated organs. Identification of the proteins involved in mediating and controlling cell-to-cell transport, especially at the companion cell-sieve element boundary, will provide an important first step towards achieving this goal.
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Liu, Zhen, Zhizhen Lv, Jiao Shi, Yubo Huang, Huazhi Huang, Hongjiao Wu, and Lijiang Lv. A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Manipulative Therapy for Patients with Chronic Neck Pain. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0123.

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Review question / Objective: Manipulative therapy has been increasingly applied to alleviate those who suffer from chronic neck pain. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to determine the efficacy of manipulative therapy for chronic neck pain. P: Patients with Chronic Neck Pain. I: Manipulative therapy. C: Exercise, rehabilitation, or other physical therapy. O: Pain intensity and Neck disability. S: Randomized controlled trials. Condition being studied: Pain in the neck is a disagreeable sensory and emotional experience associated with the potential or actual damage of tissue that affects the cervical region. Pain in the neck that lasts for a long period is a serious problem for public health that causes a lot of pressure. Manipulative therapy is usually considered an alternative treatment option with the advantages of fewer verse effects and lower treatment costs compared to exercise. Therefore, this study retrieved the relevant randomized controlled trials of manipulative therapy in the treatment of chronic neck pain and conducted a comprehensive quantitative analysis to offer an evidence-based reference for the clinical application of manipulative therapy.
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Givot, Brad, Justin Johnson, Sung Kim, Luke E. Schallinger, and James Baker-Jarvis. Characterization of tissue-equivalent materials for high-frequency applications (200 MHz to 20 GHz). Gaithersburg, MD: National Bureau of Standards, 2010. http://dx.doi.org/10.6028/nist.tn.1554.

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