Relevant bibliographies by topics / TIPIn

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Academic literature on the topic 'TIPIn'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "TIPIn"

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Smith, Kevin D., Michael A. Fu, and Eric J. Brown. "Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis." Journal of Cell Biology 187, no. 1 (October 5, 2009): 15–23. http://dx.doi.org/10.1083/jcb.200905006.

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The Tim (Timeless)–Tipin complex has been proposed to maintain genome stability by facilitating ATR-mediated Chk1 activation. However, as a replisome component, Tim–Tipin has also been suggested to couple DNA unwinding to synthesis, an activity expected to suppress single-stranded DNA (ssDNA) accumulation and limit ATR–Chk1 pathway engagement. We now demonstrate that Tim–Tipin depletion is sufficient to increase ssDNA accumulation at replication forks and stimulate ATR activity during otherwise unperturbed DNA replication. Notably, suppression of the ATR–Chk1 pathway in Tim–Tipin-deficient cells completely abrogates nucleotide incorporation in S phase, indicating that the ATR-dependent response to Tim–Tipin depletion is indispensible for continued DNA synthesis. Replication failure in ATR/Tim-deficient cells is strongly associated with synergistic increases in H2AX phosphorylation and DNA double-strand breaks, suggesting that ATR pathway activation preserves fork stability in instances of Tim–Tipin dysfunction. Together, these experiments indicate that the Tim–Tipin complex stabilizes replication forks both by preventing the accumulation of ssDNA upstream of ATR–Chk1 function and by facilitating phosphorylation of Chk1 by ATR.
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Ünsal-Kaçmaz, Keziban, Paul D. Chastain, Ping-Ping Qu, Parviz Minoo, Marila Cordeiro-Stone, Aziz Sancar, and William K. Kaufmann. "The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement." Molecular and Cellular Biology 27, no. 8 (February 12, 2007): 3131–42. http://dx.doi.org/10.1128/mcb.02190-06.

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ABSTRACT UV-induced DNA damage stalls DNA replication forks and activates the intra-S checkpoint to inhibit replicon initiation. In response to stalled replication forks, ATR phosphorylates and activates the transducer kinase Chk1 through interactions with the mediator proteins TopBP1, Claspin, and Timeless (Tim). Murine Tim recently was shown to form a complex with Tim-interacting protein (Tipin), and a similar complex was shown to exist in human cells. Knockdown of Tipin using small interfering RNA reduced the expression of Tim and reversed the intra-S checkpoint response to UVC. Tipin interacted with replication protein A (RPA) and RPA-coated DNA, and RPA promoted the loading of Tipin onto RPA-free DNA. Immunofluorescence analysis of spread DNA fibers showed that treating HeLa cells with 2.5 J/m2 UVC not only inhibited the initiation of new replicons but also reduced the rate of chain elongation at active replication forks. The depletion of Tim and Tipin reversed the UV-induced inhibition of replicon initiation but affected the rate of DNA synthesis at replication forks in different ways. In undamaged cells depleted of Tim, the apparent rate of replication fork progression was 52% of the control. In contrast, Tipin depletion had little or no effect on fork progression in unirradiated cells but significantly attenuated the UV-induced inhibition of DNA chain elongation. Together, these findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement in the absence of damage, Tipin interacts with RPA on DNA and, in UV-damaged cells, Tipin slows DNA chain elongation in active replicons.
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KESKİN, Hakkı Levent. "An Anatolian Type Metal Hammer-Axe from Bodrum Museum of Underwater Archaeology and Some Remarks on the Development, Production and Symbolic Value of This Type." Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi 59, no. 1 (June 26, 2019): 70. http://dx.doi.org/10.33171/dtcfjournal.2019.59.1.5.

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Anadolu'da Erken Tunç Çağında çok sayıda örnek ve farklı tiplerle temsil edilen sap delikli baltalar bu dönem metal silah endüstrisinin en önemli gruplarından birini oluşturmakta ve gerek kronolojik gerekse bölgelerarası ilişkiler açısından önemli veriler sunmaktadır. Bodrum Sualtı Arkeoloji Müzesi'nde bulunan ve daha önce yayınlanmamış bir çekiç balta, sap delikli metal baltaların özel bir tipini temsil etmektedir. Bu çalışma, Bodrum örneğinden hareketle bu tipin köken ve gelişim çizgisini ortaya koymak yanında olası üretim teknikleri ve kullanım biçimlerine yönelik soruları da cevaplamayı amaçlamaktadır. Benzer örneklerin bir bütün halinde değerlendirilmesi, bu tipin Batı Anadolu'ya özgü bir form olarak MÖ 3. Binyılın ortalarından sonra geliştiğini ve kısmen diğer bölgelere de yayıldığını net bir şekilde ortaya koymaktadır. Kimi örneklerin sağlam kontekstlerinden elde edilen bilgiler de bu tip eserlerin, toplumda belirli bir statüdeki bireylerin sahip oldukları güç ve iktidarın bir yansıması olarak sembolik anlamlara sahip olduğunu göstermektedir.
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Çelik, Hilal Tozlu, and Mustafa Olfaz. "Koyun ve Keçi Yetiştiriciliğinde Tipin Sabitleştirilmesi Yöntemleri." Turkish Journal of Agriculture - Food Science and Technology 3, no. 8 (August 10, 2015): 659. http://dx.doi.org/10.24925/turjaf.v3i8.659-663.428.

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Improvement studies are conduct to increasing of productivity native sheep breeds. This studies requires being quite comprehensive and disciplined. Improvement studies to achieve the desired characteristics and in which phase of finish is crucial. In this review, we focus on obtaining and fixing type in order to need to be implemented methods in sheep and goats.
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Baldeyron, Céline, Amélie Brisson, Bruno Tesson, Fariba Némati, Stéphane Koundrioukoff, Elie Saliba, Leanne De Koning, et al. "TIPIN depletion leads to apoptosis in breast cancer cells." Molecular Oncology 9, no. 8 (May 9, 2015): 1580–98. http://dx.doi.org/10.1016/j.molonc.2015.04.010.

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Errico, Alessia, Antoine Aze, and Vincenzo Costanzo. "Mta2 promotes Tipin-dependent maintenance of replication fork integrity." Cell Cycle 13, no. 13 (May 15, 2014): 2120–28. http://dx.doi.org/10.4161/cc.29157.

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Hosono, Yoshifumi, Takuya Abe, Masato Higuchi, Kosa Kajii, Shuichi Sakuraba, Shusuke Tada, Takemi Enomoto, and Masayuki Seki. "Tipin Functions in the Protection against Topoisomerase I Inhibitor." Journal of Biological Chemistry 289, no. 16 (February 25, 2014): 11374–84. http://dx.doi.org/10.1074/jbc.m113.531707.

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Antonell, M. J., C. R. Abernathy, and R. W. Gedridge. "Tellurium doping of InP using triisopropylindium-diisopropyltellurium (TIPInDIPTe)." Journal of Crystal Growth 164, no. 1-4 (July 1996): 420–24. http://dx.doi.org/10.1016/0022-0248(95)01020-3.

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GEÇGİN, Ercan. "Anadolu'da Özgün Bir Ekonomik Aktör Tipi: Homo Kaysericus." Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi 58, no. 1 (October 5, 2018): 992. http://dx.doi.org/10.33171/dtcfjournal.2018.58.1.46.

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Kayseri, dünden bugüne, toplumsal ve tarihsel açıdan pek çok karakteristik özellikleri içinde en fazla ticaret kültürüyle öne çıkan bir kent olmuştur. Binlerce yıl öncesinden bugüne kök salan ticaret kültürü, Anadolu’nun diğer illeri ile kıyaslandığında Kayseri’yi özgün bir konuma getirmiştir. Toplumun genelindeki “Kayserili” imgesinin başat özelliği ekonomik alandaki girişkenliği ve başarısı ile ölçülmüştür. Coğrafi, tarihsel ve toplumsal etkileşimlerin bileşkesiyle meydana gelen ekonomik alandaki bu hüviyet, Simmel’in “nesnel kültür” kavramıyla açıklanmaya çalışılacaktır bu çalışmada. Yine Simmel’in “form- içerik” ilişkisinden hareketle para ekonomisinin formuna uygun özgün bir ticaret tipi olarak ”Homo Kaysericus” kavramı geliştirilmeye çalışılacaktır. Kayseri’nin uzun tarihsel momentlerinde oluşan ticaret kültürü, nesnelleşmiş ve kendisine göre bir sistem ortaya çıkartarak ekonomik alandaki aktörlerin davranışlarını ve habituslarını belirleyerek bugüne kadar uzanmıştır. Ekonomik alandaki aktörler nesnel kültürün yapısı tarafından belirlenimleri olmakla birlikte aynı zamanda dönüştürücü birer eyleyen veya faildirler. Nesnel kültürün hem aktarıcısı hem de yeniden üretici aktörleridirler. Kayseri’nin ekonomik alandaki özgünlüğün taşıyıcısı olan aktörlerin ortaya çıkardığı kolektif eyleyici tipi bu çalışmada “Homo Kaysericus” olarak tanımlanmaktadır. Bu çerçevede çalışmada, bazı somut nesnel kültür örüntü verilerinden hareket edilerek bu toplumsal tipin soyutlanışına ulaşılmak istenmiştir. Kayseri’de ticaretle uğraşan aktörlerle yapılan derinlemesine görüşmeler, gözlemler, Kayseri fıkraları gibi farklı nitelikteki metinlerden hareketle Homo Kaysericus’un izi sürülmeye çalışılmış; böylece Kayseri özelinde Anadolu’daki ekonomik alanın sosyolojik çerçevesine bir katkı sunulmak istenmiştir.
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Witosch, Justine, Eva Wolf, and Naoko Mizuno. "Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex." Nucleic Acids Research 42, no. 20 (October 27, 2014): 12912–27. http://dx.doi.org/10.1093/nar/gku960.

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Dissertations / Theses on the topic "TIPIn"

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Freer, Richard William. "Growth and mechanistic investigation of novel precursors for chemical beam epitaxy growth applications." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294388.

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Witosch, Justine Martha. "Structural characterization of the Timeless-Tipin-RPA Complex and its interaction with ssDNA." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-179857.

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Witosch, Justine Martha Verfasser], and Elena [Akademischer Betreuer] [Conti. "Structural characterization of the Timeless-Tipin-RPA Complex and its interaction with ssDNA / Justine Martha Witosch. Betreuer: Elena Conti." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1068460679/34.

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Bianco, Julien. "Rôle du complexe Claspine-Timeless-Tipin dans le maintien de la stabilité du génome au cours de la réplication." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T009/document.

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Il a été montré récemment que l'instabilité génétique joue un rôle central dans les étapes précoces de la tumorigenèse. Celle-ci provoquerait une activation chronique des voies ATR/CHK1 et ATM/CHK2 dans les cellules précancéreuses, entrainant l'apoptose ou la sénescence des cellules concernées. Les mécanismes de checkpoint constituant une barrière contre la progression tumorale, toute mutation affectant ce checkpoint serait ainsi sélectionnée très tôt dans le processu s de tumorigenèse et faciliterait ensuite la progression tumorale. Ce modèle met en évidence le rôle central de l'instabilité génomique et du checkpoint dans la progression tumorale.Au cours de ma thèse, je me suis intéressé au complexe Claspine / Timeless / Tipin, initialement identifié comme médiateur de la voie ATR/CHK1 et qui est donc considéré comme ayant une fonction suppresseur de tumeur. Cependant, Claspine présente aussi des propriétés oncogéniques, puisque qu'elle est surexprimée dans de nombreuses lignées tumorales et cette surexpression est importante pour la prolifération cellulaire. Nous nous sommes donc demandé comment cette protéine pouvait être à la fois un oncogène et un suppresseur de tumeur. Chez la levure, l'homologue de Claspine est impliqué dans le maintien de la stabilité des fourches de réplication, indépendamment de sa fonction dans le checkpoint. Nous proposons que dans les cellules cancéreuses cette surexpression permette une meilleure stabilité des fourches, ce qui serait très important pour répliquer efficacement un génome soumis à un stress réplicatif constant. Au cours de ma thèse, nous avons construit et caractérisé un modèle de cellulescancéreuses HCT116 dans lesquelles nous avons diminué le niveau de Claspine ou deTimeless grâce à des shRNA, sans que cela n'affecte l'efficacité du checkpoint de réplication. Nous avons pu observer dans ces cellules un ralentissement de la progression des fourches de réplication et l'apparition d'une instabilité génétique. Il semblerait que spécifiquement dans le cas de Timeless, le ralentissement de la fourche de réplication et l'instabilité génomique se manifeste surtout dans les régions du génome répliquées tardivement
The correct execution of the replication program is essential for the maintenance of genome integrity during S phase. Indeed, replication fork progression is frequently challenged by DNA lesions and by a variety of natural pause sites. Arrested forks are unstable structures, which represent a major threat for the genome integrity if they are not promptly stabilized and restarted. In response to replicative stress, cells activated the replication checkpoint to prevent collapse of stalled forks and promote fork recovery. Recent evidence indicates that spontaneous replication stress occurs in precancerous lesions and promotes the development of cancer. Identifying the origin of this replication stress would represent a better understanding of the early stages of tumorigenesis. We study the function of Claspin, a mediator of the replication checkpoint, which plays a key role in the response to replication stress. It is therefore acting as a tumor suppressor, preventing genomic instability during DNA replication. Intriguingly, recent evidence indicates that Claspin is overexpressed in different cancers and can also acts as an oncoprotein. Studies on Mrc1p, the yeast homologue of Claspin, have shown that Mrc1 is permanently associated to forks, where it forms a complex with two partners called Tof1p and Csm3p (homologues of human Tim and Tipin respectively). We have shown by DNA combing that the replicative function of Mrc1p, is critical for viability in the presence of a replication stress. In l ight of our results in yeast, we propose that the Claspin/Tim/Tipin complex may also play a direct role for the replication of human cells. If confirmed, this replication function may account for the role of this complex in the cancer process and tumor resistance to genotoxic agents commonly used in anticancer therapy
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Grimmelsmann, Tim Albert [Verfasser]. "Biochemical and biophysical characterization of the human TIM/TIPIN/CRY complex - a potential direct link between the circadian clock and the cell cycle / Tim Albert Grimmelsmann." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1223379086/34.

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Schütz, Jan-Hendrik. "Bioinspirierte Titin-analoge Polymere." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-993F-1.

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Bioinspirierte Polymere, die die Multidomänenstruktur des Muskelproteins Titin imitieren, wurden auf Grundlage von zuvor synthetisierten, zyklischen Präpolymeren, die Wasserstoffbrückenbindungen-tragende Monomere enthalten, hergestellt und hinsichtlich ihrer mechanischen Eigenschaften untersucht.  Zunächst wurde die Ringexpansionspolymerisation (REP) zur Erzeugung zyklischer Makromoleküle, die auf einer von Nishikubo et al. entwickelten, lebenden Gruppentransferpolymerisation von Thiiranmonomeren mit Acylgruppen-tragenden Initiatoren basiert, eingehend untersucht. Im Speziellen wurde ein System, bestehend aus dem zyklischen Initiator 2,4-Thiazolidindion (TZD) und Derivaten desselben, dem Katalysator Tetrabutylammoniumchlorid, verschiedenartig substituierten Thiiranmonomeren 2-(Phenoxymethyl)thiiran (PMT), 2-Methylthiiran (MT), 2-(tert-Butoxymethyl)thiiran (TBMT), 2-((o-Methylphenoxy)methyl)thiiran (MPMT) und dem Lösungsmittel N-Methylpyrrolidin-2-on verwendet. Bei der Insertion der Monomere MT, TBMT und MPMT in TZD, die unter guter Kontrolle des Polymerisationsgrads und der Dispersität stattfand, wurde eine Verschmelzung der Ringe zu größeren Ringstrukturen mit einem Verschmelzungsgrad von bis zu zwei, bei Verwendung von PMT sogar von bis zu vier beobachtet. Der Grad dieser Verschmelzung nahm im Fall von PMT mit zunehmender Monomerkonzentration, zunehmendem molaren Monomer-zu-Initiator-Verhältnis und zunehmender Reaktionstemperatur ab, während er bei den anderen Monomeren keine Konzentrations- und Temperaturabhängigkeit zeigte. Durch Anpassung der Molmassenverteilungen mittels einer Summe von Gauß-Funktionen im Fall der PMT-Polymere konnte die zeitliche Änderung der molaren Anteile der verschiedenen Ringspezies verfolgt werden. So wurden für Polymerkonzentrationen von 14 bis 52 Gew-% Geschwindigkeitskoeffizienten der Verschmelzung, die sich über Größenordnungen von 10^(−2) bis 10^(−6) L/mol/s erstrecken, ermittelt. Bei Verwendung von in 3-Position substituierten TZD-Derivaten wurde eine Zunahme der Anzahl verschmolzener Makrozyklen von bis zu sieben festgestellt. Die Bildung zyklischer Strukturen wurde mittels Massenspektrometrie und rasterkraftmikroskopischer (AFM) Aufnahmen gezeigt.  Neben den Homopolymerisationen wurden zyklische (AB)n-Multiblockcopolymere aus MT und PMT mit bis zu acht aus der Ringverschmelzung resultierenden Blöcken synthetisiert. Sie zeigten im Zugversuch, aufgrund der verschiedenen Topologien, im Vergleich zu linearen Diblockcopolymeren ähnlicher Zusammensetzung, deutliche Unterschiede in der maximalen Zugdehnung und der Zähigkeit.  Weiterhin wurden die eingangs erwähnten bioinspirierten Polymere durch Kombination von zyklischen und linearen Segmenten hergestellt und auf ihre mechanischen Eigenschaften untersucht. Dazu wurden zyklische (ABC)n-Multiblockcopolymere, die zusätzlich einen kurzen Block des Monomers Ethyl-2-(4-(thiiran-2-ylmethoxy)benzamido)acetat (ETBAA) enthielten, der zur Ausbildung selbstkomplementärer Wasserstoffbrückenbindungen in der Lage ist, synthetisiert. Diese Präpolymere wurden mittels 1,3-dipolarer Cycloaddition in einer Polyadditionsreaktion mit einem niedermolekularen, bifunktionellen Verknüpfungsagens oder mit monofunktionellem Poly-n-butylacrylat (PBA) bzw. Polymethylacrylat (PMA), welche mittels RAFT-Polymerisation hergestellt wurden, verknüpft. So konnte im ersten Fall eine Poly-Ringpolymer-Topologie mit bis zu 19 nachgewiesenen Wiederholeinheiten und im zweiten Fall ein Polymer mit Kette–Ring–Kette-Topologie erhalten werden.  Untersuchungen der Proben im Zugversuch zeigten beim Kette–Ring–Kette-Polymer bis auf eine höhere Elastizität keine verbesserten Materialeigenschaften im Vergleich zum linearen PMA-Präpolymer. Die Poly-Ringpolymere hingegen zeigten im Gegensatz zu den Ringpolymeren ein einzigartiges Spannungs-Dehnungsverhalten, bessere Elastizitätseigenschaften und eine Erhöhung der anwendbaren Spannung bei gleicher Dehnung. Dies wurde durch den Einfluss inter- und intramolekular ausgebildeter physikalischer Bindungen durch die enthaltenen selbstkomplementären Wasserstoffbrückenbindungsmotive hervorgerufen. Eines der untersuchten Poly-Ringpolymere zeigte aufgrund der Ausbildung eines reversiblen physikalischen Netzwerkes sogar ein Formgedächtnis und die Fähigkeit zu einer partiellen Selbstheilung.
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Liversage, Alexander Duncan. "Investigations into titin/thick filament stoichiometry." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310804.

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Charton, Karine. "Etude de la physiopathologie de la dystrophie musculaire tibiale et de la dystrophie des ceintures 2J et stratégies thérapeutiques." Thesis, Evry-Val d'Essonne, 2010. http://www.theses.fr/2010EVRY0026/document.

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La titine est une protéine géante exprimée dans les muscles squelettiques et cardiaque. Un certain nombre de mutations pathogéniques ont été identifiées dans son dernier exon codant. La mutation la plus fréquente, FINmaj, conduit au remplacement de 4 acides aminés et est retrouvée chez de nombreux patients en Finlande. Cette mutation cause une dystrophiemusculaire tibiale (TMD) à l‟état hétérozygote et une dystrophie des ceintures de type 2J(LGMD2J) à l‟état homozygote.Pour obtenir une modèle d‟étude de la physiopathologie de ces maladies et évaluer des stratégiesthérapeutiques, nous avons introduit la mutation FINmaj dans le génome murin par une stratégiede Knock-In par recombinaison homologue. Ce modèle a été caractérisé et a permis de montrer qu‟il reproduit en grande partie les symptômes de la TMD et de la LGMD2J aux niveaux histologique et moléculaire. L‟étude de ce modèle murin a permis une meilleure compréhension de la physiopathologie de ces deux maladies et nous amené à étudier plus attentivement les interactions de la titine en C-ter avec ses partenaires afin de mieux comprendre l‟implication de la ligne M dans la vie du sarcomère. L‟ étude de la physiopathologie de la TMD et de la LGM2J a permis de montrer que la calpaïne 3 (une protéase à l‟origine d‟une autre dystrophie des ceintures), jouait un rôle majeur dans laTMD. Cette constatation nous a permis d‟envisager une approche thérapeutique pour cette dernière visant à diminuer les symptômes en régulant négativement la calpaïne 3. Une approche de thérapie génique a aussi été testée dans le but de traiter ces deux pathologies: le trans-épissage des derniers exons de la titine. En effet, étant donné la grande taille de l'ADNc de la titine (~100 kb), des stratégies classiques de transfert de gène n‟étaient pas envisageables. Pour s'affranchir de ce problème, nous avons testé une approche de trans-épissage de l‟ARN pour remplacer le ou les derniers exons du messager de la titine. Nous avons pu ainsi démontrer la faisabilité de la correction de la titine in vitro
Titin is a giant protein expressed in both skeletal muscles and heart. Several pathogenic mutations were identified in its last coding exon. The most frequent mutation commonly referred to as FINmaj, results in the replacement of 4 amino acids and affects a subset of patients in Finland. The mutation causes a Tibial Muscular Dystrophy (TMD) when present on one allele and a Limb Girdle Muscular Dystrophy phenotype 2J (LGMD2J) when present on both alleles.To obtain a model for studying the physiopathology of these diseases and evaluating therapeutic strategies, we introduced the FINmaj mutation in the murine genome by a knock-in strategy by homologous recombination. This model was characterized and showed that it reproduces mainly the symptoms of both the human TMD and LGMD2J at histological and molecular levels.The study of this mouse model has allowed a better understanding of the pathophysiology of these two diseases and we have to study more carefully the interactions beyond titin C-ter with its partners to better understand the involvement of the M line in life of the sarcomere.The study of the pathophysiology of TMD and LGM2J showed that calpain 3 (a protease thatlind to an other limb-girdle muscular dystrophy), played a major role in TMD. This finding allowed us to consider a treatment approach for TMD to reduce symptoms by regulating negatively calpain 3. A gene therapy approach was also tested: the trans-splicing of the last exon of titin.Indeed, given the large size of the cDNA of titin (~ 100 kb), conventional strategies of genetransfer were not envisaged. To overcome this problem, we tested an approach to exchange the last exon or the last exons of the titin messenger. We were able to demonstrate the correction of titin in vitro
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Engberg, David. "Atom Probe Tomography of TiSiN Thin Films." Licentiate thesis, Linköpings universitet, Tunnfilmsfysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122724.

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This thesis concerns the wear resistant coating TiSiN and the development of the analysis technique atom probe tomography (APT) applied to this materials system. The technique delivers compositional information through time-of-flight mass spectrometry, with sub-nanometer precision in 3D for a small volume of the sample. It is thus a powerful technique for imaging the local distribution of elements in micro and nanostructures. To gain the full benefits of the technique for the materials system in question, I have developed a method that combines APT with isotopic substitution, here demonstrated by substitution of natN with 15N. This alters the time-of-flight of ions with of one or more N and will thereby enable the differentiation of the otherwise inseparable isotopes 14N and 28Si. Signs of small-scale fluctuations in the data led the development of an algorithm needed to properly visualize these fluctuations. A method to identify the best sampling parameter for visualization of small-scale compositional fluctuations was added to an algorithm originally designed to find the best sampling parameters for measuring and visualizing strong compositional variations. With the identified sampling parameters, the nano-scale compositional fluctuations of Si in the metal/metalloid sub-lattice could be visualized. The existence and size of these fluctuations were corroborated by radial distribution functions, a technique independent of the previously determined sampling parameter. The radial distribution function algorithm was also developed further to ease in the interpretation. The number of curves could thereby be reduced by showing elements, rather than single and molecular ions (of which there were several different kinds). The improvement of the algorithm also allowed interpretation of signs regarding the stoichiometry of SiNy. With a combination of analytical transmission electron microscopy and APT we show Si segregation on the nanometer scale in arc-deposited Ti0.92Si0.0815N and Ti0.81Si0.1915N thin films. APT composition maps and proximity histograms generated from Ti-rich domains show that the TiN contain at least ~2 at. % Si for Ti0.92Si0.08N and ~5 at. % Si for Ti0.81Si0.19N, thus confirming the formation of solid solutions. The formation of relatively pure SiNy domains in the Ti0.81Si0.19N films is tied to pockets between microstructured, columnar features in the film. Finer SiNy enrichments seen in APT possibly correspond to tissue layers around TiN crystallites, thus effectively hindering growth of TiN crystallites, causing TiN renucleation and thus explaining the featherlike nanostructure within the columns of these films.
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10

Gomes, PatrÃcia Bezerra. "AvaliaÃÃo dos efeitos centrais e antinociceptivos das fraÃÃes isoladas da raiz de Petiveria alliacea L. (TIPI) em camundongos." Universidade Federal do CearÃ, 2006. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=271.

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AvaliaÃÃo dos efeitos centrais e antinociceptivos das fraÃÃes isoladas da raiz de Petiveria alliacea L. (tipi) em camundongos. PATRÃCIA BEZERRA GOMES. Orientador: Profa. Dra. Francisca ClÃa FlorenÃo de Sousa. DissertaÃÃo de Mestrado. Curso de PÃs-graduaÃÃo em Farmacologia. Departamento de Fisiologia e Farmacologia, UFC, 2006. Petiveria alliacea L. à um arbusto da famÃlia Phytolaccaceae, usada popularmente na medicina folclÃrica para o tratamento de uma ampla variedade de doenÃas nas AmÃricas do Sul e Central. As fraÃÃes acetato (FA), hexÃnica (FH), hidroalcoÃlica (FHA) e hidroalcoÃlica precipitada (FHAppt) da raiz do tipi foram estudadas para investigar suas propriedades farmacolÃgicas, nos modelos de nocicepÃÃo (contorÃÃes abdominais induzidas por Ãcido acÃtico, formalina a 1% e placa quente) e nos modelos comportamentais clÃssicos (campo aberto, labirinto em cruz elevado- LCE, rota rod, tempo de sono induzido por pentobarbital, nado forÃado e convulsÃes induzidas por pentilenotetrazol- PTZ). Foram analisados tambÃm os fitoconstituintes presentes no tipi, os efeitos farmacolÃgicos gerais e sua toxicidade aguda. As fraÃÃes foram administradas, via oral (v.o.) e/ou intraperitoneal (i.p.), nas doses de 100 e 200 mg/kg, em camundongos fÃmeas. A abordagem fitoquÃmica das fraÃÃes de Petiveria alliacea revelou a presenÃa de alcalÃides em FA, cumarinas em FA, FHA e FHAppt, saponinas e triterpenos em FA, FH, FHA e FHAppt. O extrato hidroalcoÃlico (500, 1000, 1500 e 2000 mg/kg, i.p.; 1000, 2000, 3000 e 4000 mg/kg, v.o.) do tipi apresentou uma baixa toxicidade e os parÃmetros mais visualizados foram analgesia, diminuiÃÃo da motilidade e passividade. Todas as fraÃÃes inibiram as contorÃÃes abdominais induzidas por Ãcido acÃtico. FA (200 mg/kg, i.p.), FH e FHAppt (100 e 200 mg/kg, i.p.), reduziram a nocicepÃÃo produzida pela formalina na 1 e 2 fases. FHA (100 e 200 mg/kg, i.p.) apresentou uma inibiÃÃo significativa na 1 fase deste teste, indicando um possÃvel efeito antinociceptivo. O efeito antinociceptivo produzido por FHAppt (200 mg/kg, i.p.) foi revertido pela naloxona (2mg/kg, s.c.), mostrando uma possÃvel participaÃÃo do sistema opiÃide neste processo. Nenhum efeito significativo foi observado no teste da placa quente. Todas as fraÃÃes do tipi induziram uma diminuiÃÃo significativa na atividade locomotora, rearing e grooming no teste do campo aberto, sugerindo uma possÃvel aÃÃo depressora central. Nenhum efeito significativo foi evidenciado na coordenaÃÃo motora dos animais no teste do rota rod. No LCE, FA (100 e 200 mg/kg, v.o.) reduziu o NEBA (n de entradas nos braÃos abertos) e o TPBA (tempo de permanÃncia nos braÃos abertos). FA, FH e FHA (100 e 200 mg/kg, i.p.), FHAppt (200mg/kg, i.p.) apresentaram uma significativa reduÃÃo do TPBA, indicando uma ausÃncia do efeito ansiolÃtico. As fraÃÃes da raiz de Petiveria alliacea promoveram um aumento significativo do tempo de imobilidade dos camundongos no teste do nado forÃado. AlÃm disso, corroborando estes resultados, as fraÃÃes causaram um prolongamento do tempo de sono induzido por pentobarbital, confirmando um provÃvel efeito sedativo e depressor central. Os efeitos neurofarmacolÃgicos de FHA (200 mg/kg, i.p.), observados nos testes do campo aberto e tempo de sono, nÃo foram revertidos com a administraÃÃo de flumazenil (2,5 mg/kg, i.p.), indicando que o mecanismo de aÃÃo de FHA, provavelmente, nÃo està relacionado com a participaÃÃo dos receptores GABAÃrgicos. Todas as fraÃÃes da raiz de Petiveria alliacea aumentaram a latÃncia da 1 convulsÃo e o tempo de morte das convulsÃes induzidas por PTZ nos animais, confirmando seu uso popular como anticonvulsivante. Os resultados mostraram que as diferentes fraÃÃes de Petiveria alliacea L. possuem significativo potencial antinociceptivo, sedativo, depressor e anticonvulsivante, devido à presenÃa destes constituintes, dando suporte ao uso da medicina folclÃrica desta planta.
Evaluation of the central and antinociceptive effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice. PATRÃCIA BEZERRA GOMES. Supervisor: Profa. Dra. Francisca ClÃa FlorenÃo de Sousa. Master Dissertation. Course of Post-graduation in Pharmacology. Department of Physiology and Pharmacology, UFC, 2006. Petiveria alliacea L. a shrub from Phytolaccaceae family, is popularly used in folk medicine for treating a wide variety of disorders in South and Central America. The acetate (FA), hexanic (FH), hydroalcoholic (FHA) and precipitated hydroalcoholic (FHAppt) fractions from the root of tipi were studied to investigate its pharmacological properties in animals nocicepcion models (abdominal contractions induced by acetic acid, formalin 1% and hot plate tests) and in the classical behavioral models (open-field, elevated plus maze- EPM, rota rod, barbiturate-induced sleeping time, forced swimming and pentylenetetrazole (PTZ)-induced convulsions tests). Were analyzed the phytoconstituents presents in it, the general pharmacological effects and acute toxicity. The fractions were administered orally (p.o.) and/or intraperitoneally (i.p.), at single doses of 100 and 200 mg/kg, in female mice. The phytochemical approach of the fractions from Petiveria alliacea demonstrated the presence of alkaloids in FA, coumarins in FA, FHA and FHAppt, saponins and triterpenes in FA, FH, FHA and FHAppt. The hidroalcoholic extract (500, 1000, 1500 and 2000 mg/kg, i.p.; 1000, 2000, 3000 and 4000 mg/kg, p.o.) of the tipi presented a low toxicity and the parameters more visualized were analgesic, decrease in locomotor activity and passive behavior. All the fractions inhibited the abdominal contractions induced by acetic acid. FA (200 mg/kg, i.p.), FH and FHAppt (100 and 200 mg/kg, i.p.), reduced the nocicepcion produced by formalin in the 1st and 2nd phases. FHA (100 and 200 mg/kg, i.p.) presented a significant inhibition on the 1st phase, of this test, indicating a possible antinociceptive effect. The antinociceptive effect produced by FHAppt (200 mg/kg, i.p.) was reversed by naloxone (2 mg/kg, s.c.), showing the participation of the opioid system in this process. No significant effect was observed in the hot plate test. All the fractions of tipi induced a significant decrease in the locomotor activity, rearing and grooming in the open field test, suggesting a possible central depressant action. No significant effect was evident on motor coordination of the animals in the rota rod test. On LCE, FA (100 and 200 mg/kg, p.o.) decreased the NEOA (n of entries in the open arms) and the TPOA (time of permanence in the open arms). FA, FH and FHA (100 and 200 mg/kg, i.p.), FHAppt (200mg/kg, i.p.) presented a significant reduction of the TPOA, indicating an absence of anxiolytic effect. The fractions from the root of Petiveria alliacea promoted a significant increase in the immobility time of the mice in the forced swimming test. Moreover, corroborating these results, as caused a prolongation of the pentobarbital-induced sleeping time, confirmed a probable sedative and central depressant effect. The neuropharmacological effects of the FHA (200 mg/kg, i.p.), observed in the open field and barbiturate-induced sleeping time tests, werenât reverted with the administration of the flumazenil (2.5 mg/kg, i.p.), indicating that the mechanism of action of the FHA, probably didnât related with the participation of the GABAergic receptors. All the fractions of Petiveria alliacea increased the latency to the first convulsion and the lethal time of the PTZ-induced convulsions test in the animals, confirmed its popular use as anticonvulsant. Results showed that the different fractions of Petiveria alliacea L. have significant antinociceptive, sedative, depressant and anticonvulsant potentials, due to presence in this constituents, supporting folk medicine use of this plant.
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Books on the topic "TIPIn"

1

Hughes, Mair Wynn. Tipyn osmonach! Llandysul: Gomer, 1989.

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Sentandrejski tipik. Novi Sad: Književna zajednica Novog Sada, 1990.

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Whitefield, Patrick. Tipi living. East Meon, Hampshire [England]: Permanent Publications, 2000.

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Hans Christian Andersen. Tiin tialen. Bräist: Nordfriisk Instituut, 1985.

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Crepax, Valentina. Tipi metropolitani. Milano: A. Mondadori, 1988.

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Hans Christian Andersen. Tiin tääle. Bräist: Nordfriisk Instituut, 1985.

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Ure, Jean. Tipyn o gamp. Caernarfon: Gwasg Gwynedd, 1992.

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Morgan, Michaela. Tipyn o boendod. Caerdydd: Gwasg Addysgol Drake, 2002.

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Ochirova, T. Aleksandr Ivanovich Timin. Leningrad: "Khudozhnik RSFSR", 1986.

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Đorđe, Trifunović, ed. Tipik Arhiepiskopa Nikodima. Beograd: Čigoja štampa, 2004.

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Book chapters on the topic "TIPIn"

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McEwan, Gordon F. "The Inca Heritage." In Tipon, 106–21. Reston, VA: American Society of Civil Engineers, 2006. http://dx.doi.org/10.1061/9780784408513.ch11.

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Wright, Ruth M. "Walking Tour of Tipon." In Tipon, 122–39. Reston, VA: American Society of Civil Engineers, 2006. http://dx.doi.org/10.1061/9780784408513.ch12.

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Arampatzis, Adamantios, Lida Mademli, Thomas Reilly, Mike I. Lambert, Laurent Bosquet, Jean-Paul Richalet, Thierry Busso, et al. "Titin." In Encyclopedia of Exercise Medicine in Health and Disease, 853. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_3129.

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Stöcker, W. "Autoantikörper gegen Titin." In Springer Reference Medizin, 369–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_456.

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Stöcker, W. "Autoantikörper gegen Titin." In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_456-1.

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van Duinen, Martin Th A. "Suicide by TIPI." In The Transorbital Intracranial Penetrating Injury, 108–12. Dordrecht: Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4457-5_20.

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Roberts, Albert R., and Kenneth R. Yeager. "Tipi di crisi." In Gli interventi sulla crisi, 13–15. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2029-0_5.

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Wilisch, A., A. Schultz, A. Jung, T. Kirchner, B. Schalke, K. V. Toyka, V. Pallini, S. Tzartos, H. K. Müller-Hermelink, and A. Marx. "Titin Epitope in Thymoma." In Epithelial Tumors of the Thymus, 221–27. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-0033-3_29.

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Udd, Bjarne. "Titin-related Distal Myopathies." In Muscle Disease, 171–74. Oxford, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118635469.ch18.

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van Duinen, Martin Th A. "TIPI caused by umbrellas." In The Transorbital Intracranial Penetrating Injury, 103–4. Dordrecht: Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4457-5_18.

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Conference papers on the topic "TIPIn"

1

Zhang, Lekai, Shouqian Sun, Ruimin Lyu, Kejun Zhang, and Baixi Xing. "Tipix." In SA '16: SIGGRAPH Asia 2016. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2999508.2999514.

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Sitzia, Tommaso, and Franco Viola. "Selvicoltura nei tipi neoforestali del Trentino." In Terzo Congresso Nazionale di Selvicoltura. Accademia Italiana di Scienze Forestali, 2009. http://dx.doi.org/10.4129/cns2008.037.

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van Hees, Hieronymus W. H., W. J. M. Schellekens, Gilberto Andrade, Marianne Linkels, Theo Hafmans, Coen Ottenheijm, Henk Granzier, et al. "Titin And Diaphragm Dysfunction In Mechanically Ventilated Rats." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2707.

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Angelieri, DR, ETH Freire, TPSS Stacchini, MD Costa, MCVL Cunha, L. Parmigiani, TM Torres, VG Meyer, CAR Freire, and MTH Freire. "Tipic síndrome: série de casos e revisão da literatura." In XXII Jornada Cone Sul de Reumatologia. São Paulo: Editora Blucher, 2020. http://dx.doi.org/10.5151/xxiijcsr2020-po23.

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Pereira, Carlos Bernardo, Ricardo Torres, and Paulo Soares. "MICROHARDNESS BEHAIVOUR FOR TiSiN/AlCrN AFTER HIGHT TEMPETRURE TRIBOLIGICAL TEST." In 24th ABCM International Congress of Mechanical Engineering. ABCM, 2017. http://dx.doi.org/10.26678/abcm.cobem2017.cob17-2142.

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Pereira, Carlos Bernardo, and Ricardo Torres. "EFEITO DA TEMPERATURA NO COMPORTAMENTO TRIBOLÓGICO DO REVESTIMENTO TiSiN/AlCrN." In Congresso Brasileiro de Engenharia de Fabricação. ABCM, 2017. http://dx.doi.org/10.26678/abcm.cobef2017.cof2017-0356.

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Furumai, Kouhei, Hiroki Kondo, Mitsuo Sakashita, Akira Sakai, Masaki Ogawa, and Shigeaki Zaima. "Crystalline and electrical properties of mictamict TiSiN gate MOS capacitors." In 2007 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2007. http://dx.doi.org/10.7567/ssdm.2007.p-1-10.

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San Andrés, Luis, and Wonbae Jung. "Evaluation of Coated Top Foil Bearings: Dry Friction, Drag Torque, and Dynamic Force Coefficients." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-75595.

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Despite their many advantages, bump-type foil bearings (BFBs) have issues of dry-friction during sliding contact at rotor start/stop cycles. To prevent premature wear of both shaft and the BFB, the proper selection and application of a coating on the top foil is of importance to ensure bearing long life. This thesis presents measurements characterizing the static and dynamic load performance of a Generation I BFB having uncoated and coated (VN, TiSiN, MoS2) top foils. The bearing, with length L and diameter D = 38 mm, integrates a 360° 0.127 mm thick top foil made of Inconel X-750, and a 27 bumps strip layer, 0.47 mm in height, made of the same stock as for the top foils. The VN and TiSiN coating, 0.005 mm thick, applies to the front and back surfaces of a top foil. The MoS2 coating, 0.020 mm thick, is sacrificial. The tests were conducted at room temperature (21°C), determined by the existing test facility. The dry-sliding torque (T) increases linearly with an increase in applied static load, max W/(LD) = 25.6 kPa. The bearing with a VN coated top foil shows the largest turning torque. The dry-sliding friction factor f = T/(½WD) decreases as the specific load (W/(LD)) increases. As expected, journal rotation towards the top foil free end (clockwise) produces a larger f than for rotations in reverse. A test-rig records the BFB drag torque during rotor acceleration and deceleration procedures to/from 70 krpm (138 m/s). The vertical load applied into a bearing equals W/(LD) = −8.0 kPa, 0 kPa and 8.0 kPa. In general, the bearing with a coated top foil shows a lesser drag torque than that of the uncoated top foil bearing. Among the coated foil bearings, the one with VN coating shows the highest drag torque, whereas another with MoS2 coating shows the lowest. When the rotor starts up, the dry-sliding friction coefficient (f) of the bearing with VN coating is ∼0.4 while f for the bearing with TiSiN coating is 0.3∼0.4. The uncoated bearing shows the largest f ∼0.6, and the MoS2 coated one has the lowest f = 0.2∼0.3. The drag torque, increasing with an increase in applied static load, is small when the rotor is airborne (lesser than ∼10% of peak torque). Dynamic load tests spanning excitation frequencies (ω) from 200 Hz to 400 Hz serve to identify force coefficients for the test BFBs with a specific load of 16 kPa and operating with shaft speed at 50 krpm (833 Hz). Baseline measurements correspond to a null applied load and no shaft rotation. The test bearings show a remarkable behavior with nearly isotropic direct coefficients and very small cross-coupled ones. The bearing direct stiffnesses (K) increase with frequency whereas the direct damping coefficients (C) quickly decrease. The bearing material loss factor, γ = ωC/K, represents best the BFB ability to dissipate mechanical energy. Over the excitation frequency range, γ = 0.34, 0.28, and 0.12 for the uncoated top foil, VN coated and TiSiN coated bearings. The test data show the bearing loss factor correlates with the dry friction coefficient as γ ∼ (0.71 × f) at a rotor speed of 50 krpm (95 m/s). Since the top foils with VN or TiSiN are coated on both sides, kinetic friction between the back of a top foil and the bumps’ crests likely lessens during sustained contact.
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Del Favero, Roberto. "Biodiversità nei tipi forestali: un ausilio alla gestione forestale." In Terzo Congresso Nazionale di Selvicoltura. Accademia Italiana di Scienze Forestali, 2009. http://dx.doi.org/10.4129/cns2008.005.

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Prindle, C., B. Brennan, D. Denning, I. Shahvandi, S. Guggilla, Ling Chen, C. Marcadal, D. Deyo, and U. Bhandary. "CVD TiSiN diffusion barrier integration in sub-130 mn technology nodes." In Proceedings of the IEEE 2002 International Interconnect Technology Conference. IEEE, 2002. http://dx.doi.org/10.1109/iitc.2002.1014927.

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