Academic literature on the topic 'Tinea unguium'

This report documents tinea pedis and tinea unguium in a 7-year-old child. In all cultures Trichophyton rubrum was present. As tinea pedis and tinea unguium affect adults more often than children, they might be overlooked and misdiagnosed in the latter.

ABSTRACT Traditionally, tofu, tempeh and oncom manufacture in factories usually use feet to trample soybeans so that they can be processed into tofu, tempeh or oncom. This work can cause toenails to be always moist, plus the working conditions in the factory are humid and a bit hot. Toenails that are always damp or wet, never or rarely cleaned for a long time, will trigger the appearance of a fungal disease on the nails called Tinea Unguium. This disease is usually caused by dermatophyte fungi of the species Epidermophyton floccosum, and the genus Trichophyton. This study used a Laboratory Experimental method with 9 samples of toenails of tofu and oncom factory workers. The results showed that as many as 9 samples of toenails of tofu and oncom factory workers were infected with fungi. Tinea Unguium identified as species of T. rubrum, T.mentagrophytes and Trichophyton sp, Tinea Unguium fungus identified as T. rubrum as many as 5 samples, T. mentagrophytes as many as 3 samples and Trichophyton sp. as many as 1 sample. Based on the results of the study, it was concluded that from 9 samples of toenails of tofu and oncom factory workers, 9 samples of toenails were infected with the fungus Tinea Unguium. Keywords: Tinea Unguium, Toe Nails, Trichophyton rubrum, Trichophyton mentagrophytes, Trichopyton sp. ABSTRAK Pembuatan tahu, tempe dan oncom secara tradisional di pabrik biasanya memanfaatkan kaki untuk menginjak-injak kedelai agar dapat diolah menjadi tahu, tempe atau oncom. Pekerjaan ini dapat menyebabkan kuku jari kaki selalu dalam keadaan lembap, ditambah lagi dengan kondisi ruangan kerja di dalam pabrik yang lembap dan agak panas. Kuku jari kaki yang selalu lembap atau basah, tidak pernah atau jarang dibersihkan dalam waktu lama, maka akan memicu munculnya penyakit jamur pada kuku yang disebut Tinea Unguium. Penyakit ini biasanya disebabkan oleh jamur dermatofita dari spesies Epidermophyton floccosum, dan genus Trichophyton. Penelitian ini menggunakan metode Eksperimental Laboratorium dengan sampel kuku kaki pekerja pabrik tahu dan oncom sebanyak 9 orang. Hasil penelitian menunjukkan bahwa sebanyak 9 sampel kuku kaki pekerja pabrik tahu dan oncom telah terinfeksi jamur Tinea Unguium yang diidentifikasi sebagai spesies T.rubrum, T.mentagrophytes dan Trichophyton sp, jamur Tinea Unguium teridentifikasi sebagai T.rubrum sebanyak 5 sampel, T.mentagrophytes sebanyak 3 sampel dan Trichophyton sp sebanyak 1 sampel. Berdasarkan hasil penelitian disimpulkan dari 9 sampel kuku kaki pekerja pabrik tahu dan oncom ditemukan sebanyak 9 sampel kuku kaki terinfeksi jamur Tinea Unguium. Kata Kunci: kuku kaki, Tinea Unguium, Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton sp

This study prospectively evaluated the prevalence and risk factors of tinea unguium and tinea pedis in the general adult population in Madrid, Spain. One thousand subjects were clinically examined, and samples of nails and scales from the interdigital spaces of the feet were taken from those patients presenting with signs or symptoms of onychomycosis and/or tinea pedis, respectively. In addition, a sample from the fourth interdigital space of both feet was collected from all individuals with a piece of sterilized wool carpet. Tinea unguium was defined as a positive direct examination with potassium hydroxide and culture of the etiological agent from subjects with clinically abnormal nails. Patients with positive dermatophyte cultures of foot specimens were considered to have tinea pedis. The prevalence of tinea unguium was 2.8% (4.0% for men and 1.7% for women), and the prevalence of tinea pedis was 2.9% (4.2% for men and 1.7% for women). The etiological agents of tinea unguium were identified asTrichopyton rubrum (82.1%), followed by Trichopyton mentagrophytes var. interdigitale (14.3%) andTrichopyton tonsurans (3.5%). Trichophyton rubrum (44.8%) and Trichophyton mentagrophytes(44.8%), followed by Epidermophyton floccosum (7%) andT. tonsurans (3.4%), were the organisms isolated from patients with tinea pedis. The percentage of subjects who suffered simultaneously from both diseases was 1.1% (1.7% for men and 0.6% for women). In a multivariate logistic regression analysis, age (relative risk [RR], 1.03) and gender (RR, 2.50) were independent risk factors for tinea unguium, while only gender (RR, 2.65) was predictive for the occurrence of tinea pedis. In both analyses, the presence of one of the two conditions was associated with a higher risk for the appearance of the other disease (RR, >25).

Background : Chicken traders work using both hands to clean and cut chickens. With conditions due to their lifestyle which always struggles with damp and wet triggers the emergence of skin diseases, one of which is Tinea Unguium which is caused by fungi, especially Trichophytonrubrum. Objective: The purpose of this study was to determine the presence or absence of Tinea Unguium fungus in Nail Scrapings of Chicken Traders and to determine macroscopically the condition of Chicken Traders' nails at Panorama Market, Bengkulu City. Methods: This research is descriptive observational research by testing the sample. A total of 23 samples were taken directly by scraping the nails of chicken traders. Results: Based on the results of the research, the sample of nail scrapings from chicken traders was that most of the respondents were not infected with Tinea Unguium fungus, as many as 14 respondents, 60.9%, and almost half were infected with Tinea Unguium fungus, as many as 9 respondents, 39.1%.Macroscopically from 9 traders who were infected with Tinea Unguium fungus, there were 6 traders who had clinical symptoms and 3 other traders had normal nail conditions or did not have clinical symptoms. Conclusion: concluded that The results of this studyhalf of the respondents were not infected with the fungus Tinea Purple and a small proportion of respondents were infected with the fungus Tinea Purple.Suggestion: As knowledge for the community and academics so that it becomes a reference for further research that is more varied.

Tinea unguium merupakan infeksi pada lempeng kuku yang disebabkan oleh jamur Dermatophyta. Jamur golongan Dermatophyta mempunyai sifat keratonik, sehingga dapat menyebabkan kuku rapuh dan merusak struktur kuku. Tinea unguium biasanya terjadi karena kebersihan kuku yang kurang baik dan dapat pula dari lingkungan sekitar, seperti kontak langsung dengan tanah atau lumpur. Penelitian ini bertujuan untuk mengetahui jamur Dermatophyta penyebab Tinea unguium pada kuku kaki petani di Desa Pauh Menang Kecamatan Pamenang Kabupaten Merangin, Jambi. Metodelogi penelitian ini menggunakan metode deskritif analitik. Besar sampel yang diperiksa sebanyak 30 orang. Bahan pemeriksaan ini berupa kerokan kuku kaki petani kelapa sawit yang diperiksa secara langsung KOH 20% dan pemeriksaan biakan dengan media SDA (+). Berdasarkan pemeriksaan langsung KOH 20% didapatkan elemen jamur yang mengindikasikan jamur Dermatophyta yaitu hifa sejati dan artrospora, sedangkan pemeriksaan biakan berdasarkan faktor penyebab yang diteliti,yaitupenggunaan alas kaki 3 sampel positif (20%), diketahui P. value 0,068 (p0,05). Berdasarkan jenis alas kaki yang digunakan 0 sampel positif (0%), diketahui P value 0,189 (p0,05). Dari hasil penelitian ini dapat disimpulkan bahwa ditemukan jamur Dermatophyta pada pemeriksaan langsung dan biakan dengan spesies Trichophyton rubrumdantidak ada hubungan penggunaan alas kaki dengan infeksi jamur Dermatophyta penyebab Tinea unguium pada petani kelapa sawit. Kata Kunci : Tinea unguium, Petani Kelapa Sawit, Alas Kaki.

A onicomicose é responsável por mais da metade das alterações ungueais, com prevalência em torno de 2-8%. As unhas dos pés são as mais afetadas, devido, principalmente a fungos dermatófitos (tinea unguium). A terbinafina é o único antimicótico fungicida oral e o mais potente agente contra dermatófitos in vitro. Entretanto, existem poucos estudos controlados, randomizados usando a terbinafina não-continua. Nosso objetivo foi comparar a efetividade e a segurança do tratamento da tinea unguium dos pododáctilos utilizando terbinafina oral em dois esquemas posológicos intermitentes diferentes, associado à onicoabrasão. Foram selecionados 41 pacientes com diagnóstico de onicomicose por dermatófitos, divididos em dois grupos (20 e 21 pacientes em cada), recebendo um dos seguintes tratamentos, além da onicoabrasão: Grupo I: Terbinafina oral 250mg/dia, 7 dias a cada mês; Grupo II: Terbinafina oral 500mg/dia, 7 dias a cada dois meses. Ambos os grupos tiveram duração de seis meses. Os parâmetros de avaliação da efetividade foram clínico e micológico ao término do tratamento, após seis meses e após um ano. Foram utilizados os critérios de cura total, cura parcial, melhora clínica, falha terapêutica e recidiva. Trinta e seis pacientes completaram o estudo. Não houve diferença estatística entre os grupos nos diversos parâmetros utilizados para avaliação da resposta terapêutica. A avaliação do resultado terapêutico mostra que ao final de 18 meses de acompanhamento, oito pacientes (44,4%) de cada grupo alcançaram a cura total, e que 5 (27,8%) pacientes do grupo I e 4 (22,2%) do grupo II apresentaram cura parcial. Apenas um paciente de cada grupo permaneceu com a lesão clínica inalterada durante todo o estudo. A presença dos fungos na lâmina ungueal foi sendo reduzida com o passar do estudo, ao final deste, todos os pacientes de ambos os grupos apresentaram a cultura negativa para dermatófitos. Embora o número de pacientes do estudo fosse pequeno, não houve diferença estatisticamente significativa entre os resultados de cada grupo considerando-se os parâmetros clínicos e micológicos analisados. Ambas as posologias foram consideradas seguras, sem efeitos colaterais graves, nem alterações significativas nos exames laboratoriais. Foram alcançadas taxas de cura (total e parcial) significativas nos Grupos I e II (66,6% e 72,2%, respectivamente, aos 18 meses). A cura total (disease free nail) foi obtida em 8 pacientes (44,4%) de cada grupo. O uso intermitente da terbinafina associado à onicoabrasão foi uma alternativa estatisticamente efetiva, segura e de melhor custo-benefício para o tratamento da tinea unguium dos pododáctilos, independente da posologia.
Onychomycosis constitutes up to 50% of all nail disorders and its prevalence ranges between 2-8%. The toenails are frequently affected, mostly due to dermatophytes (tinea unguium). Terbinafine is the only systemic fungicidal agent and the most potent antifungal agent in vitro against dermatophytes. However there are few randomized controlled trials using a non-continuous dose of terbinafine. The aim of this study was to compare the safety and effectiveness of two different intermittent regimens with terbinafine and nail abrasion to treat dermatophyte toenail onychomycosis. We selected 41 patients diagnosed with onychomycosis caused by dermatophytes, divided them in two groups, each receiving one of the following treatments, besides mechanical nail abrasion: Group I: oral terbinafine 250mg/day, 7 days, montly; Group II: oral terbinafine 500mg/day, 7 days, every two months. Both groups were treated for six months. The parameters used to evaluate the efficacy were clinical and mycological at the end of the treatment, six months and one year after termination. We used the following criteria: total cure, partial cure, clinical improvement, treatment failure and recurrence. Thirty-six patients completed the study. There was no statistical difference between groups in the various parameters used to evaluate therapeutic response. The evaluation of the therapeutic result reveals that after 18 months, eight patients (44.4%) of each group met the criteria for total cure, and five (27.8%) patients of group I and four (22.2%) of group II displayed partial healing. Only one patient of each group ended without any clinical improvement during the whole study. The presence of fungi in the nail plate was reducing progresively during the visits, and at the end of the study, all patients staged negative culture for dermatophytes. Despite the small number of patients of our study, there was no statistical difference between the outcomes (clinical and mycological) of each group. Both intermittent regimens were safe, without serious adverse effects, or abnormal findings in the laboratory tests performed. Significant cure rates were achieved (total and partial) in group I and II (66.6% and 72.2%, respectively, in 18 months). Eight patients (44.4%) of each group achieved the total cure (disease-free nail). The intermittent regimen of terbinafine with nail abrasion was an efficient, safe and low-cost treatment for dermatophyte toenail onychomycosis, indifferent to the regimen used.

Orientador : Wilheim Baumeier
Co-orientador : Flávio Queiroz-Telles Filho
Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Gradução em Medicina Interna
Resumo: Um estudo aberto, prospectivo, randomizado, foi realizado, empregando-se o itraconazol na terapêutica da onicomicose causada por dermatófitos. Foram comparados dois gaipos de pacientes, um que recebeu o itraconazol diariamente (grupo D = 17 pacientes) e outro onde a terapêutica foi administrada sob a forma de pulsoterapia (grupo P = 18 pacientes). Nos dois grupos, o itraconazol foi administrado durante 3 meses. Os grupos foram analisados de modo comparativo quanto à eficácia e toxicidade dos esquemas terapêuticos. Ao final da terapêutica, 59% dos pacientes do grupo D e 39% do gaipo P, apresentaram-se clinicamente responsivos. Após 4 meses de seguimento pós-terapêutico, 77% dos pacientes do gaipo D e 72% do grupo P, obtiveram resposta clínica ao tratamento. Numa segunda avaliação pós-terapêutica, aos 16 meses, todos os pacientes que compareceram ao exame e que eram responsivos na avaliação anterior, mantiveram este critério. Não se observaram diferenças estatisticamente significativas entre os grupos em ambos os períodos de avaliação da resposta terapêutica. Os dois esquemas foram bem toleradas pelos pacientes, não ocorrendo diferenças estatisticamente significativas de incidência de toxicidade clínica ou laboratorial. Em relação à quantidade total de itraconazol ingerida em cada esquema terapêutico, os pacientes do grupo D, receberam 2,14 vezes mais itraconazol que os do grupo P. Concluímos que a administração do itraconazol sob a forma de pulsoterapia, é tão eficaz quanto o esquema diário, com a vantagem de apresentar menor custo por tratamento devido à menor quantidade de medicamento utilizada.
Abstract: The pharmacokinetic profile o f itraconazole in the nails rose up a new concept in the therapy o f onychomycosis. The sustained levels that this compound achieves in the nails allows one to employ intermittent pulse therapy which is more convenient for the patient because it reduces drug intake to one week in a month. Nevertheless, comparative data o f daily administered itraconazole versus pulse therapy are missing. The aim o f this study was to compare the efficiency and toxicity o f both therapeutic schemes. We compared in a randomized trial, two groups o f patients with clinically and mycologically proved dermatophytic onychomycosis. The first group (D, 17 patients) received 200 mg o f daily itraconazole during 3 months and the second group (P, 18 patients), received 400 mg o f itraconazole per day for a week in each month, during 3 months. The severity o f the nail disease was assessed by the measurement o f the lesions, according to the method o f Zaias. Nail lesions were followed during therapy by clinical and mycological examinations while itraconazole's toxicity was studied by hematological and biochemical parameters. At the end o f the 3 months therapy, 59% of group D and 39% o f group P werw clinically responsives. After a median follow up o f 4 months( l - 6 months), starting at the end o f the therapy period, 77% patients from group D and 72% from group P, reached clinical response. There was no statistical difference between the two groups (p < 0.05). In both, itraconazole intake was well tolerated in clinical and laboratorial terms. Our results show that both itraconazole schemes can be used in the management o f dermatophytic onychomycosis. However, the total drug intake in group D patients was 2.14 higher than in group P. This difference was statistically significant and suggests that pulse therapy with itraconazole may be a more convenient and economical regimen to treat patients with onychomycosis.

Review question / Objective: To compile evidence and determine the utility of various device-based treatments for the treatment of onychomycosis, and improve the appearance of afflicted toenails. Condition being studied: Toenail onychomycosis, also known as tinea unguium. Information sources: A systematic literature search will be conducted in Scopus, MEDLINE and PubMed. The bibliographies of relevant articles will also be searched to ensure a comprehensive review is presented. Clinical trial registries (such as clinicaltrials.gov) will also be searched for complete, or incomplete trials.