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1
ANTIĆ, DEJAN D., and IVAN M. BECIĆ. "MARKET LOAN AND SAVINGS BANK OF VRANJE: 1926‒1947." ISTRAŽIVANJA, Јournal of Historical Researches, no. 30 (December 25, 2019): 217–33. http://dx.doi.org/10.19090/i.2019.30.217-233.
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The banking system of the Kingdom of Serbia, and later of the Kingdom of Yugoslavia, was principally characterized by numerous small, local money bureaus. These bureaus were founded with the purpose of providing the necessary capital and profit to their shareholders, as well as offering the ground for the capital placement in times of economic depression. The Market Loan and Savings Bank of Vranje was established in the time of a great financial crisis and is thus an example of the money bureau of the aforementioned nature. Moreover, it is the evidence of how the Great Depression affected the private banking system in the Kingdom of Yugoslavia. This paper is based on archival materials and relevant reference materials from both national and international sources.
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Epifanov, A. "From the experience of operational and service activities of the Political Bureau under the Heads of District militia departments in 1920–1921 (based on the materials of the Lower Volga and Don regions)." Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences, no. 5 (October 2, 2023): 138–44. http://dx.doi.org/10.19110/1994-5655-2023-5-138-144.
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The paper reveals the organizational and legal foundations of the activities of Political Bureaus under the Heads of the District militia departments in 1920–1921 from the historical and legal positions. On the basis of archival material introduced into scientific circulation for the first time, relating to the limits of the Lower Volga and Don regions, the author analyzes the basic principles and content of the operational and service activities of the Political Bureau, shows their results in relation to the territory of individual districts.
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Khoirudin, Rifki, and Retno Kumalasari. "Pengaruh Sektor Pariwisata Terhadap Pertmbuhan Ekonomi Di Provinsi Bali Periode 2017-2021." Journal of Economic, Bussines and Accounting (COSTING) 7, no. 1 (July 20, 2023): 205–13. http://dx.doi.org/10.31539/costing.v7i1.6475.
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ABSTRACT
Being one of the developing countries in Southeast Asia, Indonesia has an economy that is still unstable among countries. The government is trying to make new innovations in industry, agriculture, fisheries and tourism to increase economic development. The province of Bali is one of the provinces with the lowest economic growth in 2020. This can occur due to the presence of Covid-19 which is located almost all over the world. The research aims to determine the influence of the tourism sector on economic growth in the Province of Bali for the 2017-2021 period. The data used in this study is secondary data obtained from the official website of the Central Bureau of Statistics. The data includes panel data which is a combination of time series data and cross section data. Fixed Effect is a suitable model. In this study, the variables used in this study were hotels, restaurants, travel service bureaus and tourist visits. The results show that the hotel variables, travel service bureaus and tourist visits have a significant positive effect and the restaurant variables have a negative and insignificant effect on economic growth in the Province of Bali for the 2017-2021 period.
Keywords: Economic Growth, Hotels, Restaurants, Travel Service Agencies, Tourist Visits, Province of Bali
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Chrysilla, Clarissa, and Reinard Yudhaprawira. "The Existence of Notary Cooperation with Online Service Bureaus in the Making of Deeds of Establishment of Limited Liability Companies." Lex Prospicit 1, no. 2 (November 29, 2023): 120. http://dx.doi.org/10.19166/lp.v1i2.7597.
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<p>Notaries are authorized to mold all actions, agreements, and determinations desired by the parties who come to them to confirm them and pour into an authentic deed, aiming for the deed to have complete evidential power and validity. Therefore, notaries are obliged to fulfill all the provisions of their positions and other regulations and are responsible for the deeds they have prepared. In practice, especially since Covid-19 there are still notaries who cooperate with online service bureaus. The type of study is empirical juridical, which in other words is a type of sociological legal research, also known as field research, which examines the applicable legal provisions and what happens in reality in the community. From the research results obtained from decision No.36/PID.SUS/TPK/2014/PN.JKT.PST in conjunction with Cassation Court Decision No. 980 K/Pid.Sus/2015, that a notary does not check documents (the ID Card) in the creation of a company, and they aren’t to meet directly before the Notary, but with a service bureau. In this case, it is related to the validity of the company establishment deed that has been made by a notary in collaboration with an online service bureau, where the appearer does not appear before the notary because the one who appears before the notary is the service bureau. One of the main advantages of notary cooperation with online service bureaus is of course that it is not bound by working time. That the cooperation between the notaries does not have a written work bond but only in the form of verbal, however, such actions still violate the UUJN and the Notary Code of Ethics, and there have been lacunae in the law to regulate cooperation between notary and online service bureau. In the case that the author raises, notary cooperation with service bureaus is prone to criminal acts (corruption or fraud), therefore the company's deed of establishment becomes null and void. Second, the responsibility of the Notary Professional Organization, towards the Notary who cooperates with the online service bureau, which violates the provisions of the UUJN and the Code of Ethics, then based on Article 4 number 4 of the Notary Code of Ethics, it is said that the act of cooperating with an online service bureau is categorized as a violation of the notary code of ethics, which is accompanied by sanctions in the form of: Reprimand; Warning; Temporary dismissal from Association membership; Honorable dismissal from Association membership; and Dishonorable dismissal from Association membership. The INI's responsibility as a notary professional organization is as a form of providing duties and authority in providing guidance, supervision and protection to notaries.</p>
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Nagel-Frazel, Maeve. "The Queen of the Violin." Current Musicology, no. 109/110 (September 6, 2023): 1–24. http://dx.doi.org/10.52214/cm.v109i.8994.
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The commercialized nineteenth century lyceum circuit provided the vehicle for Camilla Urso (1840-1902) to become America's first celebrity female violinist. Vizualizing six seasons between 1873-83 where Urso toured under lyceum bureau management in digital maps of my own creation, I argue industrialized transportation networks combined with the commercialized advertising and publicity of the lyceum circuit created a popular concert model that expanded Urso's audience and raised her concert fees. Urso's time on the lyceum circuit laid the foundation for her transnational career. Urso was never solely a lyceum musician, though exploring the role of lyceums and their bureaus in her career plays a key role in determining how she rose to fame and became America's most celebrated female violinist. Futhermore, Urso's lyceum career argues for classical music as a rural and commercial phenomenon of American popular culture in the nineteenth century.
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Maslyhan, Olena, Erika Todierishko, Sviatoslav Zhukov, and Mariya Kashka. "Routing for tourist and excursion bureaus based at parametric network models." Economic Annals-ХХI 191, no. 7-8(1) (August 10, 2021): 100–113. http://dx.doi.org/10.21003/ea.v191-08.
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This study is devoted to applying parametric network models for the process of defining a guided tour route within route networks on the example of Denmark. This is caused by difficulty in determining variations when organizing guided tours. Under the actual digitization conditions, tourist and excursion bureaus are being restructured from static organizations administering various excursions into dynamic ones. They are actually getting adjusted to the customers’ needs and demands, taking into account the actual possibilities for covering a certain topic by the tour party within a route. The main problem encountered by tourist and excursion bureaus is the following. Although the nomenclature of presented guided tours is established by the economic entity independently, those are not always carried out according to a clearly defined itinerary and on the same conditions for all participants. When providing such services, customers’ demands and service peculiarities are not known in advance. The purpose of the present study is to provide a substantive basis for routing in tourist and excursion bureaus, based on parametric network models and taking into account the peculiarities of dynamically adaptable tables containing the best routes. To achieve the research goal, network planning methods were used, such as analytical, tabular, cloud computing in the AnyLogic Cloud environment. As a result of the study, a substantive basis of routing of the tourist route was presented for tourist and excursion bureaus, through their parametric network models. The study was implemented at the sample of the Denmark Tour -Your Guide Office, a company founded within cooperation with Russian, Ukrainian, and Denmark partners and providing travel services within the Denmark tourist market. The Office includes about 20 affiliates in Denmark, where route networks have already been adapted to designing tours in practice and parameterization of such networks is well underway, in particular by shifting the focus from the route distance rate to minimization of transfers between attraction sites. However, to provide a substantive basis for the routing in a tourist office, parameters of the routing networks should be determined not only based on the list of actions (activities) to be carried out, but also on their minimum and maximum possible duration. A lack of due attention to the servicing time for the tour groups will lead to breaking tour schedules. Thus, in 2020, as a result of the inefficient parameterization at Denmark Tour - Your Guide, about 5-6 tours around Aalborg and its vicinity were cancelled monthly. Denmark Tour- Your Guide incurs monthly profit losses at 15% in 4-6 tours around Aarhus and its surroundings, Jursland peninsula, rated at a fixed cost, as the result of payment of a fixed cost for the selected excursions. A similar situation, with breaking tour schedules and monthly losses incurred, is common with tourist and excursion bureaus in various countries around the world, including Ukraine. According to the results of the study, it is marked that the routing of tourist itineraries designed by tourist agencies, based on parametric network models turns their static time reserves and operational metrics into dynamic values depending on the duration of the tour activities. This not only ensures following schedules properly in all tours but also minimizes monthly profit loss, at an estimated EUR 2,250 for the Aalborg and its surroundings routes. Meanwhile, there may be situations where it is not possible to change the total tour cost. For example, in the company Denmark Tour - Your Guide, when working with intermediate parties, this price is fixed. To prevent incurring monthly losses within 15% of the profits for 4-6 tours of Aarhus and its surroundings, Jursland peninsula, Aalborg and Surroundings, it is necessary to make some quite specific adjustments in some activities at the sites. These should take into account the time reserve values on the longest route. A special tour activity complex is to be completed, with a maximum difference in early and late schedule times, standard and urgent pricing for the site operations). A procedure is compiled for minimizing losses in routes (over 8K euro annually), providing for completion of the activity complex within the schedule with a minimum additional charge to the operating metric (the route price), since it is not reimbursed by the tourists. It is important that the results presented should identify the path adjustments of each route simultaneously, taking into account the actual time reserve (available based on the tour group location and the previouisly completed schedule items on the tour). Prospects for practical implementation of the presented substantiation basis for the itinerary routing to be used in tourist and excursion bureaus, based on parametric network models, are in establishing facilities for creating dynamic graphic images of the whole tour procedure, in the form of a directed graph of the route network.
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Balleisen, Edward J. "American Better Business Bureaus, the Truth-in-Advertising Movement, and the Complexities of Legitimizing Business Self-Regulation over the Long Term." Politics and Governance 5, no. 1 (March 15, 2017): 42–53. http://dx.doi.org/10.17645/pag.v5i1.790.
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This essay considers the question of how strategies of legitimatizing private regulatory governance evolve over the long term. It focuses on the century-long history of the American Better Business Bureau (BBB) network, a linked set of business-funded non-governmental organizations devoted to promoting truthful marketing. The BBBs took on important roles in standard-setting, monitoring, public education, and enforcement, despite never enjoying explicit delegation of authority from Congress or state legislatures. This effort depended on building legitimacy with three separate groups with very different perspectives and interests—the business community, a fractured American state, and the American public, in their roles as consumers and investors. The BBBs initially managed to build a strong reputation with each constituency during its founding period, from 1912 to 1933. The Bureaus then in many ways adapted successfully to the emergence of a more assertive regulatory state from the New Deal through the mid 1970s. Eventually, however, the resurgence of conservative politics in the United States exposed the challenges of satisfying such divergent stakeholders, and led the BBBs to focus resolutely on shoring up its support from the business establishment. That choice, over time, undercut the Bureaus standing with other stakeholders, and especially the wider public. This history illustrates: the salience of generational amnesia within private regulatory institutions; the profound impact that the shifting nature of public faith in government can have on the strategies and reputation of private regulatory bodies; and the extent to which private regulators face long-term trade-offs among strategies to sustain legitimacy with different audiences. It also suggests a rich set of research questions for longer-term histories of other private regulatory institutions, in the United States, other societies, and at the international level.
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Najmi, Hafiz Saqib Mehmood, Farrukh Bashir, and Saman Maqsood. "Is Fiscal Policy Effective in Generating Higher Real Output? A Case of Pakistan." Pakistan Journal of Humanities and Social Sciences 1, no. 2 (December 31, 2013): 47–58. http://dx.doi.org/10.52131/pjhss.2013.0102.0004.
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Keeping in view the objective that is to observe the usefulness of fiscal policy on real GDP of Pakistan, the study collects time series data from 1976 to 2012 through reliable sources of statistical bureaus of Pakistan. Using Johansen Cointegration test, the long run results demonstrate investment and government expenditure as raising factor for real GDP of Pakistan while GDP Deflator and government revenue as de-motivating factor for real GDP of Pakistan in the long run.
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Kotaki, Akira, and Fumio Takeda. "Study on the National Disaster Management Administration System Against Huge Disasters – A Discussion Based on the Initial and Emergency Responses to the Great East Japan Earthquake –." Journal of Disaster Research 14, no. 5 (August 1, 2019): 843–60. http://dx.doi.org/10.20965/jdr.2019.p0843.
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Based on Japan’s experience of establishing and operating the Extreme Disaster Management Headquarters following the Great East Japan Earthquake of 2011, the authors conclude that it is necessary to deepen the discussion on the following issues and identify a proper direction to be pursued for establishing a disaster management administration system capable of responding appropriately to huge disasters in the future: 1) Expansion and strengthening of the Disaster Management Bureau of the Cabinet Office; 2) Establishment of the Ministry of Disaster Management or Disaster Management Agency [(a) Its relation to the Cabinet Secretariat and Cabinet Office, (b) Jurisdiction (matters related to overall coordination and duties)]; 3) Organizational design that will contribute towards establishing an effective disaster management administration system [(a) Mandatory and full-time appointment of Minister of Disaster Management, (b) Staffing system of designated posts and higher-ranking senior officials, (c) Establishment of Regional Disaster Management Bureaus, (d) Staff size, (e) Desirable approaches to human resources management (accumulation and deepening of experience in disaster response, clarifying working conditions etc.)]; etc.
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Utomo, Gayuh Budi, Rully Damayanti, and Dyan Agustin. "KOMUNIKASI BARU BIRO ARSITEK DI MASA PANDEMI DALAM PANDANGAN POSTKOLONIALISME HOMI K BHABHA." ATRIUM: Jurnal Arsitektur 6, no. 2 (November 11, 2020): 161–67. http://dx.doi.org/10.21460/atrium.v6i2.124.
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Title: New Communication of The Architecture Firms in Pandemic Era; Following the Homi K Bhabha Post Colonial View A new order called the new normal is a central issue at this time. The period before the pandemic which became a standard value and became a reference suddenly was not compatible with the arrival of the Covid-19 pandemic outbreak. This is happening in Indonesia and around the world. Everyone is in a pandemic situation for a certain period time and there is no certainty that it will end. This of course also affects how to communicate in all aspects including the architectural bureau. New ways of communicating are carried out at architectural bureaus related to social distancing and physical distancing which are considered as effective prevention methods from the COVID-19 pandemic. The types of communication that have changed are communication with clients, communication with the team and communication with interns. There are significant differences in how to communicate from offline activities to online activities where we can still be connected both ways but not in the same place. This situation is a momentum to free the bonds of limitations that have occurred in terms of communication. We want to interpret this in the postcolonialism approach of Homi K Bhabha which is very relevant to the views of hybridity, ambivalence and the third space as a way of communicating new normal discourses.
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Vining, Aidan R., Claude Laurin, and David Weimer. "The longer-run performance effects of agencification: theory and evidence from Québec agencies." Journal of Public Policy 35, no. 2 (September 9, 2014): 193–222. http://dx.doi.org/10.1017/s0143814x14000245.
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AbstractAlthough governments worldwide are increasingly choosing to deliver services through organisations with greater autonomy than traditional bureaus, the implicit assumption that such agencification contributes to long-run efficiency remains largely untested. Agencification gives agency managers more autonomy and access to incentive mechanisms that lead to greater efficiency if they are not offset by inefficiencies resulting from managerial discretion. We test the hypothesis that agencification improves efficiency by examining the longer-run performance of 13 agencies in the province of Québec, Canada over approximately 10 years. We find that these agencies experienced long-term productivity gains, but that these gains reached a plateau over the time period studied. In addition, we describe changes in several measures of performance. A survey of the managers of these agencies indicates that they perceive agencification as having a substantive impact, but worry about the sustainability of autonomy and their capacity to show continued gains in measured performance over time.
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Kleitman, Alexander, and Igor Tyumentsev. "Cannon Gunnery of Designer I.A. Makhanov: Development, Implementation, Combat Use in the 1930s – 1950s." Vestnik Volgogradskogo gosudarstvennogo universiteta. Serija 4. Istorija. Regionovedenie. Mezhdunarodnye otnoshenija, no. 1 (February 2020): 34–43. http://dx.doi.org/10.15688/jvolsu4.2020.1.3.
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Introduction. The article provides an analysis of the scientific and technical activities of I.A. Makhanov – one of the leading domestic designers, head of the experimental design bureau of the Kirov (former Putilovskiy) plant, who developed several new types of artillery weapons in the 1930s. I.A. Makhanov was repressed in 1939, and therefore his contribution to strengthening the defense of the USSR on the eve and at the beginning of the Great Patriotic War was forgotten. Methods and materials. Unpublished memoirs of I.A. Makhanov written in the 1950s – 1970s, which are currently being prepared for publication, were used as one of the main sources. Analysis. In the course of the study, it was found that under the guidance of I.A. Makhanov, in addition to experimental guns, which due to design flaws were never put into serial production (L-1, L-2), the universal gun L-3, the tank guns L-10 and L-11, and the casemate gun L-17 were developed, which in their characteristics were not inferior to other Soviet and foreign models. The fact that they were not accepted into service (L-3) or were quickly removed from service and replaced with the tools of other design bureaus (L-11 and L-17) can only be explained by the struggle of groups for the influence and power within the Soviet and party nomenclature in the 1930s. Results. Using I.A. Makhanov’s achievements in the development of artillery guns, as well as the continued work of the artillery design bureau of the Kirov plant, would have had a positive effect on the course of the Great Patriotic War and on the development of the Soviet scientific and technical sphere in the war and post-war time.
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ZALYUBOVSKYI, Mark. "TECHNICAL AND ECONOMIC RATIONALE FOR THE USE OF TURBULA TYPE MACHINING MACHINES IN POLISHING THE SURFACE OF SMALL POLYMER POLYMERS." Herald of Khmelnytskyi National University. Technical sciences 311, no. 4 (August 2022): 94–99. http://dx.doi.org/10.31891/2307-5732-2022-311-4-94-99.
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A method of wet polishing of polymer parts using a galvanizing machine with a complex spatial movement of the working tank type «Turbula» is proposed. According to the proposed method, the main stage of polishing the surface of the parts is carried out by abrasive ceramic bodies of complex geometric shape with the addition of fine pumice in the implementation of mixed cascade-waterfall mode of movement of the bulk working medium. This method of processing parts is considered highly productive, the processing time of parts averages 15 hours of continuous operation of the machine, which is several times faster than when processing parts in rotating drum drums or vibrating machines. The latter are characterized by low productivity of the relevant technological operations. The feasibility study of the method of wet polishing of polymer parts using a galvanizing machine with a complex spatial movement of the working capacity of the «Turbula» type for the implementation of the technological operation of polishing the surface of polyester buttons was performed analytically. The expected annual economic effect from the implementation of the developed method of wet polishing of polymer parts using a galvanizing machine with a complex spatial movement of the working capacity of the «Turbula» type, which will amount to UAH 14,059.8 per two units of equipment, is calculated. This method of processing can be used to improve the surface quality of any polymer parts with the possibility of achieving the appropriate value of the roughness of their surface. The obtained research results can be used in design bureaus of relevant enterprises for the manufacture of small polymer parts, the surface quality of which is determined by organoleptic method, as well as in design bureaus of machine-building enterprises specializing in the development of galvanizing equipment.
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Cao, Rui. "The Establishment of Tax Revenue Forecast Model and Its Empirical Test and Analysis." BCP Business & Management 25 (August 30, 2022): 194–201. http://dx.doi.org/10.54691/bcpbm.v25i.1755.
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Taxes are generated with the creation of the state, to satisfy the state to fulfill its functions material needs. The scale of taxation is an important indicator to measure the national financial strength and the function scope of the government in social and economic life. Tax forecasting is of great significance to tax planning and budget management. The current economic form requires the establishment of a scientific forecasting system based on tax revenue forecasting as soon as possible, so as to grasp the initiative of organizing tax revenue. Therefore, this paper adopts the methods of econometrics and time series to establish a tax revenue forecast model and conduct empirical test and economic analysis on it, trying to provide a reference for the national and local taxation bureaus to formulate scientific tax collection plans and promote a more harmonious development of the regional economy.
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Aleksandrov, A., and T. Rybalko. "Automation of the construction of finite element models for calculating the strength of ship hull structures." Transactions of the Krylov State Research Centre 1, no. 399 (March 15, 2022): 89–94. http://dx.doi.org/10.24937/2542-2324-2022-1-399-89-94.
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purpose of the work is to automate the work in the construction of a finite element model (FEM) and to calculate the strength of a vessel and marine equipment objects using the universal programming language TCL and the graphic library Tk. Materials and methods. The study is based on the use of the finite element method (FEM) and the TCL programming language. Main results. A specialized data management tool has been created at the stage of constructing a computational model, which is universal and focused on reducing time several times compared to traditional technologies in the development of spatial complex finite element vessels and marine equipment objects. Conclusion. The results of the technology of automation of the construction of a ship model and marine equipment objects can be effectively used in research institutes and design bureaus in strength calculations.
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Peppa, Maria V., Tom Komar, Wen Xiao, Phil James, Craig Robson, Jin Xing, and Stuart Barr. "Towards an End-to-End Framework of CCTV-Based Urban Traffic Volume Detection and Prediction." Sensors 21, no. 2 (January 18, 2021): 629. http://dx.doi.org/10.3390/s21020629.
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Near real-time urban traffic analysis and prediction are paramount for effective intelligent transport systems. Whilst there is a plethora of research on advanced approaches to study traffic recently, only one-third of them has focused on urban arterials. A ready-to-use framework to support decision making in local traffic bureaus using largely available IoT sensors, especially CCTV, is yet to be developed. This study presents an end-to-end urban traffic volume detection and prediction framework using CCTV image series. The framework incorporates a novel Faster R-CNN to generate vehicle counts and quantify traffic conditions. Then it investigates the performance of a statistical-based model (SARIMAX), a machine learning (random forest; RF) and a deep learning (LSTM) model to predict traffic volume 30 min in the future. Tests at six locations with varying traffic conditions under different lengths of past time series are used to train the prediction models. RF and LSTM provided the most accurate predictions, with RF being faster than LSTM. The developed framework has been successfully applied to fill data gaps under adverse weather conditions when data are missing. It can be potentially implemented in near real time at any CCTV location and integrated into an online visualization platform.
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Wahyuni, Ni Kadek, and I. Gede Wardana. "Analisis Faktor-Faktor Yang Mempengaruhi Pendapatan Sektor Pariwisata di Provinsi Bali Periode 2013-2018." E-Jurnal Ekonomi Pembangunan Universitas Udayana 11, no. 1 (January 24, 2022): 176. http://dx.doi.org/10.24843/eep.2022.v11.i01.p08.
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This study aims to determine the effect of the number of tourist visits, the number of tourist travel agencies, and the US Dollar exchange rate on the income of tourism in Bali Province when the disaster of the Mount Agung eruption occurred. The research uses panel data in the time series data from 2013-2018 and cross section 9 Districts / Cities in Bali Province. Multiple linear regression analysis techniques obtained the simultaneous of tourism sector influenced by the number of tourist visits, the number of travel service bureaus, and the US Dollar exchange rate. This result shows the increase in tourism activities for income of the tourism sector. There is a partial influence on the number of tourist visits and the number of tourist travel agencies on the income of tourism sector, while there is no influence in the partial of the US Dollar exchange rate on the income tourism in Bali Province.
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Nazarov, Yuriy V. "Review of the collective monograph «Forensic medical expert service of the Moscow region: history and modernity» edited by V.A. Klevno, V.Yu. Nazarov." Russian Journal of Forensic Medicine 8, no. 1 (April 14, 2022): 73–79. http://dx.doi.org/10.17816/fm679.
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The article analyzes the book Forensic Medical Expert Service of the Moscow region: history and modernity edited by Doctor of Medical Sciences, Professor Vladimir Alexandrovich Klevno and Doctor of Medical Sciences, Associate Professor Viktor Yurievich Nazarov, presents an objective assessment of the published data on the history and current state of the forensic medical expert service of the Moscow region and the development of Russias largest state forensic institution State Budgetary Healthcare Institution of the Moscow region Bureau of Forensic Medical Examination. The purpose of the review is to give an objective assessment of the information contained in the scientific publication and to determine their value for science and practice.
First of all, the author notes the uniqueness of the publication, in which for the first time the history of forensic medicine of the Moscow region is covered in detail and reliably, the main milestones of the history of the Bureaus development are scrupulously and carefully outlined, an unprecedented number of little-known facts and reliably generalized information are included (archival data, accurate statistical reports, detailed biographies). The conclusion is substantiated that by its 100th anniversary, the state budgetary healthcare institution of the Moscow region Bureau of Forensic Medical Examination, under the leadership of Professor V.A. Klevno, has achieved leading positions in all indicators of forensic expert activity and has become the leading among state forensic expert institutions in the healthcare system of the Russian Federation. It is noted that the book Forensic Medical Expert Service of the Moscow region: history and modernity, written at the highest scientific level, includes an unprecedented amount of little-known and reliably generalized information.
The author noted that the book was written at the highest scientific level and, undoubtedly, is a significant contribution to the history of the national forensic medical service.
It can be argued that with the publication of the book Forensic Medical Expert Service of the Moscow Region: History and Modernity, a whole and reliable picture of the true history of the Moscow Regional forensic medicine is being created, covering the main significant time intervals.
Without a doubt, this work will serve for many years as a source of reliable information for forensic experts, historians and a wide range of people interested in the past, present and future of forensic medicine in Russia.
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Newsome, Scott D., Philip J. Aliotta, Jacquelyn Bainbridge, Susan E. Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, et al. "A Framework of Care in Multiple Sclerosis, Part 1." International Journal of MS Care 18, no. 6 (November 1, 2016): 314–23. http://dx.doi.org/10.7224/1537-2073.2016-051.
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CME/CNE Information Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. Target Audience: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). Learning Objectives: Apply new information about MS to a comprehensive individualized treatment plan for patients with MS Integrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MS Accreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group. The CMSC is accredited by the ACCME to provide continuing medical education for physicians. The CMSC designates this journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurse Practitioner Alternatives (NPA) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation. NPA designates this enduring material for 1.0 Continuing Nursing Education credit. Laurie Scudder, DNP, NP, has served as Nurse Planner for this activity. She has disclosed no relevant financial relationships. Disclosures: Francois Bethoux, MD, Editor in Chief of the International Journal of MS Care (IJMSC), has served as Physician Planner for this activity. He has received royalties from Springer Publishing and has received intellectual property rights from Biogen. Laurie Scudder, DNP, NP, has served as Nurse Planner for this activity. She has disclosed no relevant financial relationships. Scott D. Newsome, DO, MSCS (author), has served on scientific advisory boards for Biogen, Genentech, Novartis, and Genzyme, and has performed contracted research (institution received funds) for Biogen, Genentech, and Novartis. Philip J. Aliotta, MD, MSHA, CHCQM, FACS (author), has served on speakers' bureaus for Astellas Pharma, Actavis, Augmenix, and Allergan and has performed contracted research for Allergan. Jacquelyn Bainbridge, PharmD (author), has disclosed no relevant financial relationships. Susan E. Bennett, PT, DPT, EdD, NCS, MSCS (author), has served on speakers' bureaus for Acorda Therapeutics, Biogen, and Medtronic; has received consulting fees from and performed contracted research for Acorda Therapeutics; and is chair of the Clinical Events Committee at Innovative Technologies. Gary Cutter, PhD (author), has participated on Data and Safety Monitoring Committees for AMO Pharma, Apotek, Gilead Pharmaceuticals, Horizon Pharmaceuticals, Modigenetech/Prolor, Merck, Merck/Pfizer, Opko Biologics, Neuren, Sanofi-Aventis, Reata Pharmaceuticals, Receptos/Celgene, Teva Pharmaceuticals, NHLBI (Protocol Review Committee), and NICHD (OPRU Oversight Committee); has received consulting fees from and/or served on speakers' bureaus and scientific advisory boards for Cerespir, Genzyme, Genentech, Innate Therapeutics, Janssen Pharmaceuticals, Klein-Buendel Incorporated, MedImmune, Medday, Nivalis, Novartis, Opexa Therapeutics, Roche, Savara, Somahlution, Teva Pharmaceuticals, Transparency Life Sciences, and TG Therapeutics; and is President of Pythagoras, Inc., a private consulting company located in Birmingham, AL. Kaylan Fenton, CRNP, APNP, MSCN (author), has disclosed no relevant financial relationships. Fred Lublin, MD (author), has received consulting fees/fees for non-CME/CE activities from Bayer HealthCare Pharmaceuticals, Biogen, EMD Serono, Novartis, Teva Neuroscience, Actelion, Sanofi/Genzyme, Acorda, Questcor/Mallinckrodt, Roche/Genentech, MedImmune, Osmotica, Xenoport, Receptos/Celgene, Forward Pharma, Akros, TG Therapeutics, AbbVie, Toyama, Amgen, Medday, Atara Biotherapeutics, Polypharma, Pfizer, Johnson & Johnson, Revalesio, Coronado Bioscience, and Bristol-Myers Squibb; has served on speakers' bureaus for Genentech/Roche and Genzyme/Sanofi; has performed contracted research for Acorda, Biogen, Novartis, Teva Neuroscience, Genzyme, Xenoport, and Receptos; is the co–chief editor of Multiple Sclerosis and Related Disorders; and has an ownership interest in Cognition Pharmaceuticals. Dorothy Northrop, MSW, ACSW (author), has disclosed no relevant financial relationships. David Rintell, EdD (author), has received consulting fees from Novartis and has served as a patient education speaker for Teva Neuroscience. He started as a salaried employee of Sanofi Genzyme in November 2015. Dr. Rintell's work on this project was completed before he became a salaried employee of Sanofi Genzyme. Bryan D. Walker, MHS, PA-C (author), has served on scientific advisory boards for EMD Serono and Sanofi Genzyme and owns stock in Biogen. Megan Weigel, DNP, ARNP-C, MSCN (author), has received consulting fees from Mallinckrodt, Genzyme, and Genentech, and has served on speakers' bureaus for Bayer Corp, Acorda Therapeutics, Teva Neuroscience, Biogen, Mallinckrodt, Genzyme, Novartis, and Pfizer. Kathleen Zackowski, PhD, OTR, MSCS (author), has performed contracted research for Acorda Therapeutics. David E. Jones, MD (author), has received consulting fees from Biogen and Novartis, and has performed contracted research for Biogen. One anonymous peer reviewer for the IJMSC has performed contracted research (institution received funds) for Novartis, Chugai, and Biogen. Another reviewer has received consulting fees and served on speakers' bureaus for Biogen, Sanofi Genzyme, Genentech, EMD Serono, and Novartis. The third reviewer has disclosed no relevant financial relationships. Lori Saslow, MS (medical writer), has disclosed no relevant financial relationships. The staff at the IJMSC, CMSC, NPA, and Delaware Media Group who are in a position to influence content have disclosed no relevant financial relationships. Note: Disclosures listed for authors are those applicable at the time of their work on this project and within 12 months previously. Financial relationships for some authors may have changed in the interval between the time of their work on this project and publication of the article. Funding/Support: Funding for the Framework of Care consensus conference was provided by the Consortium of Multiple Sclerosis Centers, Mallinckrodt Pharmaceuticals, and Mylan Pharmaceuticals. Method of Participation: Release Date: December 1, 2016 Valid for Credit Through: December 1, 2017 In order to receive CME/CNE credit, participants must:Review the CME/CNE information, including learning objectives and author disclosures.Study the educational content.Complete the post-test and evaluation, which are available at http://www.cmscscholar.org. Statements of Credit are awarded upon successful completion of the post-test with a passing score of >70% and the evaluation. There is no fee to participate in this activity. Disclosure of Unlabeled Use: This CME/CNE activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA. CMSC, NPA, and Delaware Media Group do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of CMSC, NPA, or Delaware Media Group. Disclaimer: Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any medications, diagnostic procedures, or treatments discussed in this publication should not be used by clinicians or other health-care professionals without first evaluating their patients' conditions, considering possible contraindications or risks, reviewing any applicable manufacturer's product information, and comparing any therapeutic approach with the recommendations of other authorities.
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Brown, Peter. "How Muscovy Governed: Seventeenth-Century Russian Central Administration." Russian History 36, no. 4 (2009): 459–529. http://dx.doi.org/10.1163/009428809x12536994047659.
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AbstractThe modern Russian state's first governmental administration, the chancellery system (prikaznaia sistema), guided Muscovy from the 1470s to the 1710s. A handful of state secretaries (d'iaki), subordinate clerks (pod'iachie), and several nascent bureaus matured into over ten permanent, well-codified bodies with decision-making boards, archives, professional hierarchies, and merit-based hiring and promotion by the 1550s. By the 1670s there were 60 chancelleries, and their Moscow staffs by the 1690s had increased to about 3,000, from the highest civil ranks (boyars and okol'niche) through the professional administrative ranks: duma state secretaries (dumnye d'iaki), the state secretaries, and clerks. The chancelleries (prikazy) discharged an array of state, royal court, and church functions, but military concerns were foremost. An arresting internal complexity typified the larger, more important chancelleries, like the Military and Foreign Affairs Chancelleries, divided into sub-units. The chancellery system was entirely homegrown, owning nothing to Roman Imperial and Medieval Latin traditions. The Russians borrowed some paperwork (scrolls) and zealous attention to that from the Mongols, as they did Byzantine and Lithuanian legal elements. Documentary language was a vernacular, Middle Russian register, with burgeoning specialized vocabulary and phraseology. Strict oaths guided conduct, though judicial bureau personnel were notorious for bribe-taking. Foreign travel accounts commented on the obsequiousness of documentary format wherein petitioners referred to themselves as “slaves” (kholopy) and used first-name diminutives. Seventeenth-century Muscovite centralized administration acquired Weber's hallmark features of a bureaucracy; the prikazy guided Muscovy and acculturated its subjects, from tsar to peasant, into its rationale, mechanisms, and operations. Weathering major social traumas and challenges, such as Ivan the Terrible's Oprichnina, the Time of Troubles, the Thirteen Years' War, and the 1682 Musketeers' Uprising, the chancelleries provided the bureaucratic continuity for the Imperial Russian and Soviet states.
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Sousounis, Panos, and Gauthier Lanot. "Social networks and unemployment exit in Great Britain." International Journal of Social Economics 45, no. 8 (August 13, 2018): 1205–26. http://dx.doi.org/10.1108/ijse-04-2017-0137.
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Purpose The purpose of this paper is to examine the effect employed friends have on the probability of exiting unemployment of an unemployed worker according to his/her educational (skill) level. Design/methodology/approach In common with studies on unemployment duration, this paper uses a discrete-time hazard model. Findings The paper finds that the conditional probability of finding work is between 24 and 34 per cent higher per period for each additional employed friend for job seekers with intermediate skills. Social implications These results are of interest since they suggest that the reach of national employment agencies could extend beyond individuals in direct contact with first-line employment support bureaus. Originality/value Because of the lack of appropriate longitudinal information, the majority of empirical studies in the area assess the influence of social networks on employment status using proxy measures of social interactions. The current study contributes to the very limited empirical literature of the influence of social networks on job attainment using direct measures of social structures.
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Holmen, Rasmus Bøgh, Nicolas Gavoille, Jaan Masso, and Arūnas Burinskas. "Internationalization in the Baltic Regional Accounts: A NUTS 3 Region Dataset." Data 8, no. 12 (November 30, 2023): 181. http://dx.doi.org/10.3390/data8120181.
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Features of internationalization, such as trade, foreign direct investments, and international migration, are crucial for understanding the economic developments of small and open economies. However, studying internationalization at the country level may obscure significant heterogeneity in its relationship with economic growth and other economic and social outcomes. Regional accounts provide insights into the geography of internationalization, but collections of such disaggregated statistics are rarely provided by statistical bureaus. The purpose of this paper is twofold. First, we demonstrate how regional account data, including internationalization indicators, can be constructed to obtain consistent and homogeneous regional-level series using a combination of micro and macro data sources. Second, our aim is to foster spatial research on internationalization and the spatial economy in the Baltics by providing comprehensive data collection of socio-economic variables at the NUTS 3 regional level over time. This collection encompasses trade, FDI, and migration, enabling the study of internationalization and other features of the Baltic economy. We present a series of key features, revealing noticeable correlation patterns between regional development and internationalization.
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Ruperto, N., H. Brunner, A. Berman, F. Avila Zapata, G. Horneff, L. Wagner-Weiner, A. Belot, et al. "POS0340 PREDICTORS OF CLINICAL RESPONSE TO ABATACEPT IN CHILDREN WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 422.2–423. http://dx.doi.org/10.1136/annrheumdis-2022-eular.604.
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BackgroundFor children with polyarticular juvenile idiopathic arthritis (pJIA) and inadequate response or intolerance to initial treatment with MTX, treatment options include abatacept.1 Abatacept, a selective T-cell co-stimulation modulator, has a distinct mechanism of action from other current treatments for rheumatic diseases,2 and factors predicting clinical response can help determine optimal treatment strategy. Two phase 3 studies demonstrated the efficacy and safety of IV and SC abatacept in patients with pJIA and an inadequate response to other DMARDs.2,3ObjectivesTo determine baseline and post-baseline factors that may predict a clinical response in children and adolescents with pJIA treated with abatacept for 2 years.MethodsBaseline demographic and disease characteristics and post-baseline factors (50% and 70% improvement in ACR criteria [ACR50, ACR70] at days 57 and 85) were analyzed using data from 2 phase 3 studies of abatacept in patients with JIA aged 2–17 years (SC administration) and 6–17 years (IV administration). Efficacy endpoints were Juvenile Arthritis Disease Activity Score in 10 joints based on CRP (JADAS10-CRP) inactive disease (ID; score of ≤ 2.7),4 and remission, defined as 6 consecutive months of post-baseline JADAS10-CRP ID. Data were analyzed over the entire 2-year study period. The earliest time point at which patients achieved these outcomes was reported. The aforementioned study factors were subjected to a time-to-event analysis, including Cox proportional hazards univariate regression analysis and Cox proportional hazards multivariate regression analysis using stepwise regression; results of the multivariate analysis are reported. Kaplan–Meier analysis was used to estimate time to achieve clinical response. Receiver operating characteristic curves were used to determine threshold values for continuous variables.ResultsOverall, 347 patients were included in the analysis (SC, n = 219; IV, n = 128; 73.8% female; mean [SD] age, 11.3 [4.0] years). Following abatacept treatment, both time to JADAS10-CRP ID and time to JADAS10-CRP remission were predicted (nominal P ≤ 0.05) by age (≤ 11 years: hazard ratio [HR], 1.52 [95% CI, 1.14–2.02] and ≤ 10 years: HR, 1.73 [95% CI, 1.20–2.48], respectively), high-sensitivity CRP (hsCRP; ≤ 0.6 mg/dL: HR, 1.67 [95% CI, 1.22–2.28] and ≤ 0.21 mg/dL: HR, 1.67 [95% CI, 1.15–2.42], respectively), Parent/Patient Global Assessment of well-being (≤ 35.86: HR, 1.88 [95% CI, 1.41–2.51] and ≤ 43.16: HR, 2.05 [95% CI, 1.35–3.10], respectively), and Childhood HAQ-DI (CHAQ-DI; ≤ 1.63: HR, 2.23 [95% CI, 1.47–3.39] and ≤ 0.75: HR, 1.84 [95% CI, 1.24–2.73], respectively) (remission data shown in Figure 1). Disease duration ≤ 2 years from baseline (HR, 1.66 [95% CI, 1.25–2.21]) and SC route of administration (HR, 2.05 [95% CI, 1.45–2.91]) also predicted ID. Among the post-baseline factors, ACR50 at days 57 and 85 predicted both ID (HR, 1.57 [95% CI, 1.04–2.36] and HR, 1.88 [95% CI, 1.41–2.51], respectively) and remission (HR, 1.96 [95% CI, 1.11–3.45] and HR, 3.05 [95% CI, 1.47–6.34], respectively); ACR70 at day 57 also predicted ID (data not shown). Patients with predictive factors for age, hsCRP, Parent/Patient Global Assessment of well-being, and CHAQ-DI, and with lower disease activity achieved ID and/or remission earlier than patients with high disease activity.ConclusionWe identified baseline and post-baseline factors that predicted JADAS10-CRP ID and remission in patients with pJIA treated with abatacept for 2 years. Screening of abatacept-treated patients with pJIA for such factors may help predict earlier achievement of ID and/or remission.References[1]Ringold S, et al. Arthritis Rheumatol 2019;71:846–63.[2]Brunner HI, et al. Arthritis Rheumatol 2018;70:1144–54.[3]Ruperto N, et al. Lancet 2008;372:383–91.[4]Trincianti C, et al. Arthritis Rheumatol 2021;73:1966–75.AcknowledgementsThis study was sponsored by Bristol Myers Squibb. Writing and editorial assistance were provided by Candice Judith Dcosta, MSc, of Caudex, funded by Bristol Myers Squibb. We would like to acknowledge Mara Becker, Duke Clinical Research Institute, Durham, NC, USA, for her contribution to the study analysis.Disclosure of InterestsNicolino Ruperto Speakers bureau: Honoraria for consultancies or speaker bureaus from the following pharmaceutical companies in the past 3 years: 2 Bridge, Amgen, AstraZeneca, Aurinia, Bayer, Brystol Myers Squibb, Cambridge Healthcare Research, Celgene, Domain Therapeutic, Eli Lilly, EMD Serono, GlaxoSmithKline, Idorsia, inMed, Janssen, Novartis, Pfizer, Sobi, UCB, Consultant of: Honoraria for consultancies or speaker bureaus from the following pharmaceutical companies in the past 3 years: 2 Bridge, Amgen, AstraZeneca, Aurinia, Bayer, Brystol Myers Squibb, Cambridge Healthcare Research, Celgene, Domain Therapeutic, Eli Lilly, EMD Serono, GlaxoSmithKline, Idorsia, inMed, Janssen, Novartis, Pfizer, Sobi, UCB, Hermine Brunner Speakers bureau: GlaxoSmithKline, Novartis, Pfizer, Consultant of: AbbVie, AstraZeneca-Medimmune, Biogen, Boehringer, Bristol Myers Squibb, Celgene, Cerocor, Eli Lilly, EMD Serono, F. Hoffmann-La Roche, GlaxoSmithKline, Idorsia, Janssen, Merck, Novartis, R-Pharm, Sanofi, Grant/research support from: The Cincinnati Children’s Hospital, where HIB works as a full-time public employee, has received contributions from the following industries in the past 3 years: Bristol Myers Squibb, F. Hoffmann-La Roche, Janssen, Novartis, and Pfizer. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment to third parties, Alberto Berman Grant/research support from: AbbVie, Amgen, Bristol Myers Squibb, Lilly, Novartis, Pfizer, Roche, Francisco Avila Zapata: None declared, Gerd Horneff Speakers bureau: AbbVie, Chugai, Janssen, Novartis, Pfizer, Grant/research support from: AbbVie, Chugai, MSD, Novartis, Pfizer, Roche, Linda Wagner-Weiner Grant/research support from: Abbott, Bristol Myers Squibb, Merck, Pfizer, UCB, Alexander Belot Speakers bureau: Chugai, GlaxoSmithKline, Novartis, Roche (punctual scientific intervention), Grant/research support from: Boehringer Ingelheim, Merck (joint research project), Ruben Burgos-Vargas: None declared, Maria Luz Gámir Gámir: None declared, Claudia Goldenstein-Schainberg Speakers bureau: AbbVie, Janssen, Novartis, Consultant of: AbbVie, Janssen, Novartis, Maria T. Terreri: None declared, Margarita Askelson Consultant of: Acerta Pharma, Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Robert Wong Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Alberto Martini Consultant of: AbbVie, Eli Lilly, EMD Serono, Idorsia, Janssen, Novartis, Pfizer, Daniel J Lovell Consultant of: AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Hoffman LaRoche, Novartis, UBC (all contracts with employer, CCHMC), Grant/research support from: Bristol Myers Squibb, Janssen, Pfizer, Roche (all contracts with employer, CCHMC); NIH grants: NIAMS, NICHD
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Kania, Ikeu. "Implementation of the KIR E-Test Program in the Technical Implementation Unit of the Motor Vehicle Testing Service of the Garut Regency Transportation Service." International Journal of Science and Society 3, no. 3 (August 23, 2021): 251–58. http://dx.doi.org/10.54783/ijsoc.v3i3.369.
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Implementing the KIR e-test program at the UPTD of the Garut Regency Transportation Service has been carried out since October 1, 2019. The KIR e-test program is a service innovation by changing the manual KIR test system using an IT-based system so that the KIR e-test application can simplify and shorten the service time for people who will do the KIR test. This study uses a qualitative method with descriptive analysis. The data collection techniques used include observation, interviews, and documentation. The data analysis technique used is data reduction, data presentation and conclusion drawing. From the results of the study, it was concluded that the implementation of the KIR e-test program had been implemented but encountered several obstacles, including information on changes in testing procedures from manual to electronic has not been informed to the public, so there are still people who think that the testing procedures carried out take a long time, so that vehicle owners prefer to use the services of brokers in testing the UPTD PKB Dishub Garut still lacks testers, especially testers who are certified and do not have a backup of e-KIR infrastructure. Implementing the KIR e-test is still prone to illegal levies because there are still brokers who call themselves service bureaus in collaboration with unscrupulous officers.
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Smolenkova, Julia A. "Dubai Expo 2020. A Look Into the Future." Scientific and analytical journal Burganov House. The space of culture 18, no. 3 (June 10, 2022): 87–91. http://dx.doi.org/10.36340/2071-6818-2022-18-3-87-91.
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The emergence of the World's Fairs was closely connected with construction and the industrial revolution - and the desire to showcase its achievements. At the Expo, people first saw much of what is now our everyday reality: from telephones, the first artificial satellite of the Earth and the Otis elevator to ice cream in a waffle cone. Expo 2020 allows us to look into our future and touch it, full of new technologies, different realities and respect for history and culture. Dubai Expo 2020 is the first World Expo in the Middle East and the first in the history (170 years) Expo where all of 192 participating countries have their own pavilions. If we add partner and thematic pavilions to this, we get a grandiose city of the future. The UAE, as the host country of the EXPO, has indeed become the centre of global peace for half a year. Leading experts from all over the world have rushed to the exhibition. Expo 2020 is an opportunity to see dozens of projects by the best architects and bureaus from all over the world at the same time.
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Zhang, Jiayan. "Economic Development in the Name of Protecting the Environment in Rural China: The Case of the Swan Islet National Nature Reserves." Rural China 17, no. 1 (May 12, 2020): 135–50. http://dx.doi.org/10.1163/22136746-01701007.
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Swan Islet, located in the old course of the Yangzi River in Shishou, Hubei, central China, was chosen as a nature reserve first to conserve milu 麋鹿 (Père David’s deer) in 1987 and white-fin dolphins 白鱀豚 in 1992. The local government then built dikes to protect this area from the annual high water of the Yangzi River, which turned a considerable amount of riverside wasteland into reclaimable land attractive to the local farmers. At the same time, more land was needed to feed the fast-growing herds of milu. In the river, dolphins and fisherfolk compete for resources. Different interests have caused conflicts between the government, farmers, and fisherfolk. Conflicts between governmental bureaus has made things even more complicated. With the increasing appeal of wetland preservation, the local government added wetland preservation to its agenda and applied for financial support from upper-level governments. Attempting to lure tourists with milu—a “national treasure”—and original wetlands, the local government is hoping to promote eco-tourism and eventually to boost local economic growth, all in the name of protecting the environment.
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Zeng, Jingjing, Meng Yuan, and Richard Feiock. "What Drives People to Complain about Environmental Issues? An Analysis Based on Panel Data Crossing Provinces of China." Sustainability 11, no. 4 (February 21, 2019): 1147. http://dx.doi.org/10.3390/su11041147.
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Strengthening public participation has often proven essential for achieving environmental sustainability goals. The “Xinfang”system, through complaint visits and letters, offers institutional channels through which the public’s grievances can be addressed, and where court judgments can be challenged by filing complaints about environmental problems to Environmental Protection Bureaus. Operating under the monopoly of the state Party, the “Xinfang” system provides the political opportunity for pro-environmental values and interests to be voiced and heard by governments. Importantly, comprehending the evolution of public complaints over a prolonged period of time sheds light on various determinants of this public participation program. This paper seeks to better understand environmental degradation caused by unbridled economic growth in China and the efforts that civic environmentalism has made to reduce the problem. More specifically, it uses panel data on 31 Chinese provincial/first level administrative units, collected over a decade, from 2003 to 2015, to analyze how socioeconomic status in the general public and the political and policy structures have shaped civic environmentalism. We use two Ordinary Least Squares (OLS) models to explore how these actors have propelled the public to protect their environment from discharged industrial wastewater, industrial waste gas, and solid wastes.
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Newsome, Scott D., Philip J. Aliotta, Jacquelyn Bainbridge, Susan E. Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, et al. "A Framework of Care in Multiple Sclerosis, Part 2." International Journal of MS Care 19, no. 1 (January 1, 2017): 42–56. http://dx.doi.org/10.7224/1537-2073.2016-062.
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CME/CNE Information Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. Target Audience: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). Learning Objectives: Apply new information about MS to a comprehensive individualized treatment plan for patients with MS Adjust rehabilitative interventions to accommodate for fluctuating or ongoing MS symptoms Accreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group. The CMSC is accredited by the ACCME to provide continuing medical education for physicians. The CMSC designates this journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurse Practitioner Alternatives (NPA) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation. NPA designates this enduring material for 1.0 Continuing Nursing Education credit. Laurie Scudder, DNP, NP, has served as Nurse Planner for this activity. She has disclosed no relevant financial relationships. Disclosures: Francois Bethoux, MD, Editor in Chief of the International Journal of MS Care (IJMSC), has served as Physician Planner for this activity. He has received royalties from Springer Publishing; has received intellectual property rights from Biogen; has received consulting fees from Acorda Therapeutics, Ipsen, and Merz Pharma; and has performed contracted research for Acorda Therapeutics. Laurie Scudder, DNP, NP, has served as Nurse Planner for this activity. She has disclosed no relevant financial relationships. Scott D. Newsome, DO, MSCS (author), has served on scientific advisory boards for Biogen, Genentech, Novartis, and Genzyme and has performed contracted research (institution received funds) for Biogen, Genentech, and Novartis. Philip J. Aliotta, MD, MSHA, CHCQM, FACS (author), has served on speakers' bureaus for Astellas Pharma, Actavis, Augmenix, and Allergan and has performed contracted research for Allergan. Jacquelyn Bainbridge, PharmD (author), has disclosed no relevant financial relationships. Susan E. Bennett, PT, DPT, EdD, NCS, MSCS (author), has served on speakers' bureaus for Acorda Therapeutics, Biogen, and Medtronic; has received consulting fees from and performed contracted research for Acorda Therapeutics; and is chair of the Clinical Events Committee at Innovative Technologies. Gary Cutter, PhD (author), has participated on Data and Safety Monitoring Committees for AMO Pharma, Apotek, Gilead Pharmaceuticals, Horizon Pharmaceuticals, Modigenetech/Prolor, Merck, Merck/Pfizer, Opko Biologics, Neuren, Sanofi-Aventis, Reata Pharmaceuticals, Receptos/Celgene, Teva Pharmaceuticals, NHLBI (Protocol Review Committee), and NICHD (OPRU Oversight Committee); has received consulting fees from and/or served on speakers' bureaus and scientific advisory boards for Cerespir, Genzyme, Genentech, Innate Therapeutics, Janssen Pharmaceuticals, Klein-Buendel Incorporated, MedImmune, Medday, Nivalis, Novartis, Opexa Therapeutics, Roche, Savara, Somahlution, Teva Pharmaceuticals, Transparency Life Sciences, and TG Therapeutics; and is President of Pythagoras, Inc., a private consulting company located in Birmingham, AL. Kaylan Fenton, CRNP, APNP, MSCN (author), has disclosed no relevant financial relationships. Fred Lublin, MD (author), has received consulting fees/fees for non-CME/CE activities from Bayer HealthCare Pharmaceuticals, Biogen, EMD Serono, Novartis, Teva Neuroscience, Actelion, Sanofi/Genzyme, Acorda, Questcor/Mallinckrodt, Roche/Genentech, MedImmune, Osmotica, Xenoport, Receptos/Celgene, Forward Pharma, Akros, TG Therapeutics, AbbVie, Toyama, Amgen, Medday, Atara Biotherapeutics, Polypharma, Pfizer, Johnson & Johnson, Revalesio, Coronado Bioscience, and Bristol-Myers Squibb; has served on speakers' bureaus for Genentech/Roche and Genzyme/Sanofi; has performed contracted research for Acorda, Biogen, Novartis, Teva Neuroscience, Genzyme, Xenoport, and Receptos; is the co–chief editor of Multiple Sclerosis and Related Disorders; and has an ownership interest in Cognition Pharmaceuticals. Dorothy Northrop, MSW, ACSW (author), has disclosed no relevant financial relationships. David Rintell, EdD (author), has received consulting fees from Novartis and has served as a patient education speaker for Teva Neuroscience. He started as a salaried employee of Sanofi Genzyme in November 2015. Dr. Rintell's work on this project was completed before he became a salaried employee of Sanofi Genzyme. Bryan D. Walker, MHS, PA-C (author), has served on scientific advisory boards for EMD Serono and Sanofi Genzyme and owns stock in Biogen. Megan Weigel, DNP, ARNP-C, MSCN (author), has received consulting fees from Mallinckrodt, Genzyme, and Genentech, and has served on speakers' bureaus for Bayer Corp, Acorda Therapeutics, Teva Neuroscience, Biogen, Mallinckrodt, Genzyme, Novartis, and Pfizer. Kathleen Zackowski, PhD, OTR, MSCS (author), has performed contracted research for Acorda Therapeutics. David E. Jones, MD (author), has received consulting fees from Biogen, Novartis, and Genzyme and has performed contracted research for Biogen (institution received funds). One anonymous peer reviewer for the IJMSC has performed contracted research (institution received funds) for Novartis, Chugai, and Biogen. Another reviewer has received consulting fees and served on speakers' bureaus for Biogen, Sanofi Genzyme, Genentech, EMD Serono, and Novartis. The third reviewer has disclosed no relevant financial relationships. Lori Saslow, MS (medical writer), has disclosed no relevant financial relationships. The staff at the IJMSC, CMSC, NPA, and Delaware Media Group who are in a position to influence content have disclosed no relevant financial relationships. Note: Disclosures listed for authors are those applicable at the time of their work on this project and within 12 months previously. Financial relationships for some authors may have changed in the interval between the time of their work on this project and publication of the article. Funding/Support: Funding for the Framework of Care consensus conference was provided by the Consortium of Multiple Sclerosis Centers, Mallinckrodt Pharmaceuticals, and Mylan Pharmaceuticals. Method of Participation: Release Date: February 1, 2017 Valid for Credit Through: February 1, 2018 In order to receive CME/CNE credit, participants must:Review the CME/CNE information, including learning objectives and author disclosures.Study the educational content.Complete the post-test and evaluation, which are available at http://www.cmscscholar.org. Statements of Credit are awarded upon successful completion of the post-test with a passing score of >70% and the evaluation. There is no fee to participate in this activity. Disclosure of Unlabeled Use: This CME/CNE activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA. CMSC, NPA, and Delaware Media Group do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of CMSC, NPA, or Delaware Media Group. Disclaimer: Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any medications, diagnostic procedures, or treatments discussed in this publication should not be used by clinicians or other health-care professionals without first evaluating their patients' conditions, considering possible contraindications or risks, reviewing any applicable manufacturer's product information, and comparing any therapeutic approach with the recommendations of other authorities.
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Zhou, Liangjun, and James J. Zhang. "Variables affecting the market demand of sport lottery sales in China." International Journal of Sports Marketing and Sponsorship 18, no. 1 (February 6, 2017): 116–36. http://dx.doi.org/10.1108/ijsms-05-2016-0026.
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Purpose The purpose of this paper is to examine the market demand of sport lottery in China from the following perspectives: available types and varieties of sport lottery, number of retail outlets, public welfare funds, promotion costs, per capita income, and population. Design/methodology/approach As the earliest province of issuing the sales of sport lottery and having one of the largest sales volumes in China, Guangdong Province was chosen for conducting the current study. Data were obtained from 14 sport lottery administration and distribution centers and statistics bureaus of 14 corresponding municipal cities. Multiple regression analysis was used. Findings Multiple regression analyses revealed that number of retail outlets, promotion cost, per capita income, and public welfare funds were positively (p<0.05) predictive of sport lottery sales; however, available types and varieties of sport lottery were not found to be significantly (p>0.05) related to total sport lottery sales. The findings are discussed in the context of theories and practices in the marketing and administration of sport lottery sales in China. Research limitations/implications Similar studies are suggested to be conducted in provinces and regions beyond Guangdong Province. Originality/value This study combined socioeconomic characteristics of the population, lottery game characteristics and management factors for the first time.
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MOLDOVAN, Octavian, and Felicia Cornelia MACARIE. "The Transformation of Romanian Internal Public Audit between 2006 and 2020." Transylvanian Review of Administrative Sciences, no. 67 E (October 28, 2022): 21–43. http://dx.doi.org/10.24193/tras.67e.2.
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"The article analyzes how internal public audit (IPA) transformed in Romania between 2006 and 2020, in order to explore: (a) the degree in which cen tral and local public institutions organized their IPA activities as a specialized department or in an asso ciative structure; (b) how did the human resources allocated to IPA activities transformed in this period (focusing on employment, the ability to cover the needs of public organizations and the educational/ professional specialization of internal auditors), and (c) how IPA missions changed over time. The empiri cal research consists of a detailed analysis of official annual reports published by the Central Harmoniza tion Unit for Internal Public Audit, thus ensuring the reliability of the analysis. Our main results indicate the existence of multiple differences between central and local public organi zations, regarding their degree/level of IPA activities organization (especially before 2013) and the num ber of organizations each internal public auditor was tasked to audit (ranging from 1 at the central level to almost 8 at the local level). Unfortunately, the under staffing of IPA departments/ bureaus is not condu cive to an accurate identification and assessment of potential organizational weaknesses and risks, thus potentially hindering the performance of both central and local public institutions. "
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Kumar P.M., Suresh. "Professions in Transition: A case of Marriage Brokers." RESEARCH REVIEW International Journal of Multidisciplinary 8, no. 6 (June 15, 2023): 01–05. http://dx.doi.org/10.31305/rrijm.2023.v08.n06.001.
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Traditional marriages are characterized by the involvement of parents in the search for picking a preferred choice for concluding the wedding of their son or daughter. Intermediaries played a crucial role in bringing together alliances from far and wide. Such individuals were usually professionals specialized in the field called as marriage brokers. Over time, as a consequence of many changes in society, the practice of individual doorstep services gave way to walk-in institutional services. These came to be known as Marriage Bureaus. The invasion of technology in all walks of life further transformed the practice. Online platforms and application services emerged. This paper is an attempt to capture the transformation from person-based to institution-based and technology-based services so as to throw light on the traditional occupational role of brokers. The shift from person-managed to technology-managed service is to be seen as a change from custom to system. This study is a qualitative study undertaken in Kerala, a traditionally compact society where the prevalence of the custom is glaring to illuminate. In-depth interviews were conducted through a purposeful selection of respondents including beneficiaries of services and veteran brokers. The study examines brokering as a profession in traditional societies and attempts to articulate the change in practices.
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., Rochmad. "AKTUALISASI TEKNOLOGI DALAM PEMBELAJARAN PENDIDIKAN AGAMA ISLAM." Jurnal PROGRESS: Wahana Kreativitas dan Intelektualitas 8, no. 1 (June 28, 2020): 62. http://dx.doi.org/10.31942/pgrs.v8i1.3445.
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Abstract
The development of the era from the traditional, now entering the modern era. That is, many people are now spoiled with technological. In the past, people traveled to one city with another city requires a lot of time. Furthermore, people see the world still using the Globe and the information needed takes a long time. Conditions are inversely proportional after the public knows the technology. Society is facilitated and spoiled with technology. When lazy to move all what we need today can be directly delivered today. In this era, service bureaus have begun to stand up everywhere. Now there is no need to worry about the daily needs that are needed. Likewise in the world of education. Therefore, the development of the times certainly also requires a technology.
Keywords: Technology, Learning, Islamic Religious Education.
Abstrak
Perkembangan zaman dimulai dari tradisional, kemudian sekarang memasuki era modern. Artinya, banyak masyarakat sekarang yang dimanjakan dengan kecanggihan teknologi. Dahulu, orang bepergian ke kota satu dengan kota yang lain membutuhkan banyak waktu. Selanjutnya, masyarakat melihat dunia masih menggunakan Globe dan informasi yang dibutuhkan diperlukan waktu yang lama. Kondisi berbanding tebalik setelah masyarakat mengetahui teknologi. Masyarakat dipermudah dan dimanjakan dengan teknologi. Ketika malas bergerak semua apa yang kita butuhkan hari ini bisa langsung diantar hari ini juga. Di era ini, biro jasa sudah mulai berdiri dimana-mana. Sekarang tidak perlu khawatir tentang kebutuhan sehari-hari yang dibutuhkan. Begitu juga dalam dunia pendidikan. Karenanya, perkembangan zaman tentunya juga membutuhkan sebuah teknologi.
Kata Kunci: Teknologi, Pembelajaran, Pendidikan Agama Islam
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Simpson, Elizabeth, Edward Miller, Molly Wylie, and Marc Cohen. "Providing Nursing Home Care in an Era of Increasing Scarcity: The Case of Pennsylvania." Innovation in Aging 5, Supplement_1 (December 1, 2021): 501. http://dx.doi.org/10.1093/geroni/igab046.1935.
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Abstract Medicaid financing of nursing home (NH) care provides the strongest safety net for low income older adults, persons who have high-intensity long-term care (LTC) needs, and consumers with exorbitant LTC costs. Yet, NHs currently face serious threats to their financial viability, particularly in the context of the COVID-19 pandemic, where the costs of caring for residents in a safe way have increased significantly, even as the ability to recoup these costs from the Medicaid program has been constrained. The purpose of this study is to assess key demand and supply factors affecting the performance of the NH industry in Pennsylvania over time. It draws from several large, national data sources, including NH Compare, LTCFocus.org, the U.S. Bureaus of the Census and Labor Statistics, and Certification and Survey Provider Enhanced Reports, as well as state-level population projections and Departments of Health and Human Services data. An aggregate database was constructed with historical data points at the facility, regional, and state level. Annual total and regional trends were examined from 2010 to 2020. Findings suggest a growing gap between what NHs require to meet the needs of residents and the level of reimbursement paid by the largest funder: Medicaid. Considering demographic trends, this gap will only grow over time in the absence of policy change. The pandemic has further highlighted the existing challenges resulting from an underfunded service infrastructure and the need for additional investment if NHs are to provide high quality care to a growing cohort of older adults requiring support.
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Hariyanto, Eko, Sri Wahyuni, and Supina Batubara. "Study of Potential Classification of Lost Students in College Based on Information Extraction on Text-Based Social Media; Case Study of Panca Budi Pembangunan University." International Journal of Research and Review 8, no. 11 (November 29, 2021): 325–31. http://dx.doi.org/10.52403/ijrr.20211140.
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The main problem studied in this study is the large number of lost students who harm universities because of the difficulty of monitoring or monitoring as a preventive measure. Therefore, this research becomes very important to be done so that college institutions can make efforts to detect early (classification) of students who potentially cannot complete their studies on time or students who will drop out (DO). Thus, PT institutions through related parties such as academic guidance lecturers, academic bureaus and others can do initial prevention by providing the best solution or solution to the problems faced by students. This research aims to determine the training data model consisting of academic and non-academic factors (including the results of extracting information from social media). Furthermore, this model is used as a basis for classifying students who have the potential to "graduate on time", "graduate not on time", and "DO". The method approach used is quantitative with text mining computational algorithms for the process of extracting knowledge / information from social media which is further used in data training, as well as data mining computational algorithms for the process of classification of potential completion of student studies. The mandatory external targeted in the first year is the publication of the international journal Scopus Q4 and in the second year is the publication of the international journal Scopus Q3. For additional external targets in the first and second years respectively are the publication of international journals indexed on reputable indexers, ISBN teaching books and copyrights. The level of technological readiness (TKT) in this study up to level 2 is the formulation of technological concepts and applications to classify the potential completion of student studies using data mining. Keywords: [student lost, knowledge/information extraction, data classification, text mining, data mining].
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VASILIEV, DENIS E. "MECHANIZED CLEANING AND DISINFECTION OF SECTIONAL INSTRUMENTS USING ULTRASOUND AS ONE OF THE STAGES OF IMPROVING ANTI-EPIDEMIC MEASURES IN THE BUREAU OF FORENSIC MEDICINE." Bulletin of Contemporary Clinical Medicine 14, no. 6 (November 2021): 28–32. http://dx.doi.org/10.20969/vskm.2021.14(6).28-32.
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Introduction. An analysis of the most time-consuming and dangerous tasks for medical personnel shows that one of them is the cleaning of medical instruments from contamination. The same applies to sectional instruments used in the operations of the Bureau of Forensic Medicine during autopsy of corpses. To solve this problem, mechanized cleaning through the use of ultrasonic cleaners is increasingly applied in global practice. Aim. The aim of the work was to organize the washing and disinfection of sectional instruments by mechanized method using ultrasonic washers and to evaluate the efficiency and quality of instrument cleaning. Material and methods. We analyzed the experience of the Republican Bureau of Forensic Medicine of the Ministry of Health of the Republic of Tatarstan in the organization ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2021 Том 14, вып. 6 29ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ and provision of washing and disinfection of sectional instruments. We developed basic principles of operation and standard operating procedures for the personnel of thanatology department with regard to mechanized washing and disinfection of sectional instruments in ultrasonic washing. We evaluated the effectiveness of the implemented measures by conducting sanitary and bacteriological examination and by testing the effectiveness of ultrasound treatment of instruments. Results and discussion. Ensuring the safety of personnel working in the expert institution dictates the necessity of mechanization and automation of production processes in the area of cleaning and disinfection of metal instruments. In this regard, standard operating procedures for personnel based on the current regulatory documents were developed and implemented. The effectiveness of the implemented measures was further evaluated. Sanitary and bacteriological studies in the control group (before the implementation of standard operating procedures) revealed E. coli bacteria in 15% of the samples. Staphylococcus aureus was not detected in any of the samples. All samples containing E. coli group bacteria were in the washes taken from the scissors. In the experimental group (after implementation of standard operating procedures), E. coli and Staphylococcus aureus bacteria were not detected in all samples. When evaluating the efficiency of instrument washing in an ultrasonic washer, 98,33% of SteriTEC indicators for instrument cleaning reached the optimal variant. Conclusion. Thus, the introduction of modern, mechanized methods of instrument processing into the activities of medical and preventive treatment institutions, in particular forensic medicine bureaus, can significantly improve the quality of cleaning and disinfection of metal instruments involved in the performance of examinations. Such innovations must be accompanied by a comprehensive approach in solving sanitary and hygienic problems and be supported by clear guidelines and standard operating procedures for personnel.
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Kale, Aniket, Akshata Shinde, Sushant Patil, and Prof Rajesh Kadu. "Criminal Navigation System / Extractor." International Journal for Research in Applied Science and Engineering Technology 10, no. 5 (May 31, 2022): 490–95. http://dx.doi.org/10.22214/ijraset.2022.42054.
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Abstract: We proposed a criminal navigation system/extractor that retains a criminal's records and also forecasts primary suspects in this paper. The method is intended to assist agencies such as the CBI, CID, and other similar bureaus in expediting the investigation process. Case summary, people involved, conflicts, past criminal histories of those engaged, items recovered on scene, and other facts such as facial recognition and fingerprints are all included in the system. The system recognises the type of case and allows the administrator to update the investigation's status and submit more crime photographs. It investigates past criminal histories of all those involved and makes recommendations for suspects based on this information. There is no proper centralised database or tracking criteria for criminal investigation in the area of criminal navigation. This system is based on criminal records management and a criminal navigation system. The system has the most up-to-date information on previous crimes. Those recordings will be useful in future investigations and training for new police. Officers will save time and the investigative process will be sped up as a result of the technology. The suggested method is intended to encourage criminal investigation teams to collaborate on cases and to expedite the investigative process by proposing suspects. Keywords: Admin, Officer, fingerprint, face recognition, primary suspect prediction
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Weiss, P. F., T. G. Brandon, A. Aggarwal, R. Burgos-Vargas, R. A. Colbert, G. Horneff, R. Joos, et al. "POS0173 DATA-DRIVEN MRI DEFINITIONS FOR ACTIVE AND STRUCTURAL SACROILIAC JOINT LESIONS IN JUVENILE SPONDYLOARTHRITIS TYPICAL OF AXIAL DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 316–17. http://dx.doi.org/10.1136/annrheumdis-2022-eular.741.
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BackgroundFor classification in juvenile spondyloarthritis (JSpA), it is important to develop cut-offs for active and structural lesions typical of axial disease on MRI that are readily and consistently interpreted. Since the maturing sacroiliac joint (SIJ) looks different from the adult SIJ, the criteria developed for positive MRI in adults may not be applicable in JSpA.ObjectivesAs part of a study developing classification criteria for axial disease in JSpA, we aimed to determine quantitative SIJ imaging lesion cut-offs for inflammatory and structural lesions typical of axial JSpA using majority imaging expert decision as the reference criterion.MethodsSubjects were a retrospective cohort of children with SpA who met the provisional Pediatric Rheumatology International Trials Organization criteria for enthesitis/spondylitis-related juvenile idiopathic arthritis or had a rheumatologist JSpA diagnosis. All subjects had symptom onset prior to age 18 years and underwent MRI as part of a diagnostic evaluation for axial disease. To enable SIJ quadrant-based scoring, all MRIs included semi-coronal slices through the cartilaginous part of the joint on fluid sensitive sequences and on T1-weighted sequences for the assessment of inflammation and structural lesions, respectively. MRIs were reviewed by 6 musculoskeletal imaging experts who were blinded to clinical details. MRI evaluation of the SIJ was based on standardized lesion definitions that were decided by consensus of the central imaging team and represented a mix of definitions from ASAS and the Juvenile Arthritis MRI Score Outcome Measures in Rheumatology working group. Using a web-based interface, raters globally assessed the presence or absence of lesions typical of axial SpA and performed SIJ quadrant or joint based scoring. Lesion scores were generated by averaging the scores of all raters. Sensitivity and specificity of lesion cut-offs were calculated using rater majority (≥4/6 raters) on a global assessment of the presence/absence of active or structural lesions typical of axial SpA with high confidence (confidence of ±3 or stronger on confidence scale from -5, “Definitely No”, to +5, “Definitely Yes”) as the reference standard.ResultsImaging from 243 subjects, 61% male, median age 14.9 years, had sequences available for detailed MRI scoring. Active inflammatory lesion typical of axial disease in JSpA was defined as bone marrow edema (BME) in at least 3 SIJ quadrants (sensitivity 98.6%, specificity 96.5%). For structural lesion typical of axial JSpA, the optimal cut-off was erosion in at least 3 quadrants or at least one of the following lesions in at least 2 SIJ quadrants: sclerosis, fat lesion, backfill, ankylosis (sensitivity 98.6%, specificity 95.5%).ConclusionWe propose data-driven cut-offs for active inflammatory and structural lesions on MRI typical of axial disease in JSpA that have high specificity and sensitivity using central imaging global assessment as the reference standard.Table 1.Performance of cut-offs for inflammatory and structural lesions of axial diseaseCut-offs for number of SIJ quadrants (any location)Sensitivity (95% CI)Specificity (95% CI)Definite active lesionBME score ≥2100 (95.0-100)93.5 (88.7-96.7)BME score ≥398.6 (92.5-100)96.5 (92.5-98.7)BME, same location on ≥3 consecutive slices88.6 (78.7-94.9)98.8 (95.8-99.9)Definite structural lesionErosion ≥295.7 (88-99.1)96.8 (92.7-99)Erosion, same location on ≥2 consecutive slices94.3 (86-98.4)98.1 (94.5-99.6)Erosion ≥391.4 (82.3-96.8)98.7 (95.4-99.8)Sclerosis ≥262.9 (50.5-74.1)98.1 (94.5-99.6)Fat lesion ≥222.9 (13.7-34.4%)98.7 (95.4-99.8%)Backfill ≥220 (11.4-31.3)100 (97.7-100)Ankylosis ≥21.3 (0.2-4.7)100 (94.9-100)ANY of the following in ≥2 SIJ quadrants: erosion, sclerosis, fat lesion, backfill, ankylosis98.6 (92.3-100)93.6 (88.5-96.9)Erosion ≥3 quadrants OR ≥2 quadrants of at least one of the following lesions: sclerosis, fat, backfill, ankylosis98.6 (92.3-100.0)95.5 (91.0-98.2)Disclosure of InterestsPamela F. Weiss Consultant of: PfizerNovartisBiogenLilly(All <$5K in the past fiscal year), Timothy G. Brandon: None declared, Amita Aggarwal: None declared, Ruben Burgos-Vargas Speakers bureau: Not in the last three years.Novartis, Consultant of: Not in the last four years.BMS, Lilly, Novartis, Robert A. Colbert: None declared, Gerd Horneff Speakers bureau: Pfizer, Novartis, Janssen, Chugai, Abbvie, Grant/research support from: Pfizer, Novartis, MSD, Chugai, Roche, Abbvie, Rik Joos Speakers bureau: Galapagos, Pfizer, AbbVie, Novartis, Amgen, BMS, Lilly, Grant/research support from: Pfizer, AbbVie, Roche, Ronald Laxer Consultant of: Abbvie, Novartis, Sobi, Sanofi, Eli Lilly Canada, Eli Lilly, Kirsten Minden Speakers bureau: Pfizer, Novartis, Consultant of: Pfizer, Novartis, Angelo Ravelli Speakers bureau: Abbvie, Novartis, SOBI, Angelini, Reckitt-Benkiser, Roche, Pfizer, Alexion, Grant/research support from: Novartis, Pfizer, Nicolino Ruperto Speakers bureau: NR has received honoraria for consultancies or speaker bureaus from the following pharmaceutical companies in the past 3 years: 2 Bridge, Amgen, AstraZeneca, Aurinia, Bayer, Brystol Myers and Squibb, Celgene, inMed, Cambridge Healthcare Research, Domain Therapeutic, EMD Serono, Glaxo Smith Kline, Idorsia, Janssen, Eli Lilly, Novartis, Pfizer, Sobi, UCB., Consultant of: NR has received honoraria for consultancies or speaker bureaus from the following pharmaceutical companies in the past 3 years: 2 Bridge, Amgen, AstraZeneca, Aurinia, Bayer, Brystol Myers and Squibb, Celgene, inMed, Cambridge Healthcare Research, Domain Therapeutic, EMD Serono, Glaxo Smith Kline, Idorsia, Janssen, Eli Lilly, Novartis, Pfizer, Sobi, UCB., Grant/research support from: The IRCCS Istituto Giannina Gaslini (IGG), where NR works as full-time public employee has received contributions from the following industries in the last 3 years: Bristol Myers and Squibb, Eli-Lilly, F Hoffmann-La Roche, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties., Judith Smith Consultant of: Consulting panel of pediatric rheumatologists identifying issues in juvenile spondyloarthritis for Novartis. Paid < $5000, Matthew L. Stoll Consultant of: Currently consulting for Novartis, Shirley ML Tse: None declared, Filip van den Bosch Speakers bureau: Abbvie, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer, UCB, Paid instructor for: Amgen, Eli Lilly, Consultant of: Abbvie, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer, UCB, Robert G Lambert Paid instructor for: Novartis, Consultant of: CARE Arthritis, Calyx, Image Analysis Group, Novartis, David M. Biko Employee of: Merck (1998-2000), Nancy A. Chauvin Employee of: Forest Pharmaceuticals - Research scientist (1996) and Novartis - Pharmaceutical sales representative (1997), Michael L. Francavilla: None declared, Jacob L Jaremko: None declared, Nele Herregods: None declared, Ozgur Kasapcopur Speakers bureau: Pfizer, Abbvie, Novartis and Roche, Mehmet YILDIZ: None declared, Alison M. Hendry: None declared, Walter P Maksymowych Speakers bureau: Abbvie, Eli-Lilly, Janssen, Novartis, Pfizer, UCB Pharma, Consultant of: AbbVie, Boehringer Ingelheim, Celgene, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer, UCB Pharma, Grant/research support from: Abbvie, Novartis, Pfizer
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Liu, Jun, and Jing Wang. "Social data governance: From reflective practices to comparative synthesis." Big Data & Society 9, no. 2 (July 2022): 205395172211397. http://dx.doi.org/10.1177/20539517221139786.
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This special theme brings together reflections and deliberations regarding the design, implementation, and development of data governance. By addressing “social data governance” as the keyword of the special theme, we aim to further the discussion on a contextual understanding of both the governing foundations and effects of data, dataism, and datafication in different societies. Such a discussion reminds us to pay particular attention to—and thus account for—the social dynamics that underpin and contextualize the design, operation, and promotion of quantified governing mechanisms in which information on social behaviors is collected, datafied, manipulated, and represented. Essentially, the social dynamics of data governance have existed for a long time and in many forms, ranging from credit bureaus’ scrutiny, evaluation, and labeling of their customers to internet-enabled massive data collection and scoring systems used by governments, and to automated contact tracing techniques as a centerpiece of dataveillance and infection control amid the COVID-19 pandemic. Nevertheless, scholarly work from a wide range of disciplines like law, mathematics, and business and with diverse geographical foci has not yet been comparatively and reflectively articulated. Being rich and diverse, the special theme advances such a requisite understanding of the status and relevance of social dynamics of data governance mechanisms based on a wide range of empirical cases around the globe. To scrutinize the social dynamics helps illuminate and contrast divergent manifestations of data governance and their underlying mechanisms.
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Teculeasa, Flavia, Florinda Golu, and Adrian Gorbănescu. "Professional quality of life in the child protection system: The mediating role of attachment security and closeness in the child-employee dyad." International Journal of Population Studies 9, no. 2 (August 1, 2023): 0884. http://dx.doi.org/10.36922/ijps.0884.
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Child protection workers who interact with vulnerable children daily are indirectly exposed to multiple traumatic events, and the possibility of experiencing burnout and secondary traumatic stress (STS) is high. Concurrently with these outcomes, positive results can occur in this type of activity, which are experienced in the form of compassion satisfaction. The purpose of this study is to explain the effect personal adverse childhood experiences (ACEs) exert on the professional quality of life (ProQOL) of selected categories of employees (foster parents, psychologists, and social workers), via the employees’ attachment security and closeness toward the children they work with. This study is the first to investigate factors that influence the development of ProQOL in a more complex sample of child protection workers. Data were collected at a single point in time with the help of 11 Child Protection Services Bureaus from Romania, using an online survey, yielding 223 participants, including 130 foster parents and 93 specialists. The mediating model was tested with structural equation modeling. The overall fit of the model is acceptable. The indirect effects of ACEs on the components of ProQOL are statistically significant, and attachment security and closeness in the child-employee dyad act as protective factors against the development of burnout and STS in this sample. Findings confirm the beneficial effects of employee attachment security and closeness towards children they work with on their ProQOL. These results could be implemented by considering attachment-based approaches in supporting professionals.
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Novak, James I., and Jonathon O’Neill. "A design for additive manufacturing case study: fingerprint stool on a BigRep ONE." Rapid Prototyping Journal 25, no. 6 (July 8, 2019): 1069–79. http://dx.doi.org/10.1108/rpj-10-2018-0278.
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Purpose This paper aims to present new qualitative and quantitative data about the recently released “BigRep ONE” 3 D printer led by the design of a one-off customized stool. Design/methodology/approach A design for additive manufacturing (DfAM) framework was adopted, with simulation data iteratively informing the final design. Findings Process parameters can vary manufacturing costs of a stool by over AU$1,000 and vary print time by over 100 h. Following simulation, designers can use the knowledge to inform iteration, with a second variation of the design being approximately 50 per cent cheaper and approximately 50 per cent faster to manufacture. Metrology data reveal a tolerance = 0.342 per cent in overall dimensions, and surface roughness data are presented for a 0.5 mm layer height. Research limitations/implications Led by design, this study did not seek to explore the full gamut of settings available in slicing software, focusing predominantly on nozzle diameter, layer height and number of walls alongside the recommended settings from BigRep. The study reveals numerous areas for future research, including more technical studies. Practical implications When knowledge and techniques from desktop 3 D printing are scaled up to dimensions measuring in meters, new opportunities and challenges are presented for design engineers. Print times and material costs in particular are scaled up significantly, and this study provides numerous considerations for research centers, 3 D printing bureaus and manufacturers considering large-scale fused filament fabrication manufacturing. Originality/value This is the first peer-reviewed study involving the BigRep ONE, and new knowledge is presented about the practical application of the printer through a design-led project. Important relationships between material volume/cost and print time are valuable for early adopters.
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ZALYUBOVSKYI, Mark, and Igor PANASYUK. "ANALYTICAL INVESTIGATION OF SOME CONSTRUCTIVE PARAMETERS OF A HOLDING MACHINE WITH TWO WORKING CAPACITIES CONNECTED BETWEEN EACH OTHER." Herald of Khmelnytskyi National University. Technical sciences 307, no. 2 (May 2, 2022): 97–102. http://dx.doi.org/10.31891/2307-5732-2022-307-2-97-102.
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The disadvantages of using machine mechanisms in the kinematic circuits of which contain a passive connection are described. A three-dimensional statically defined mechanism of the “Turbula” type machine without the presence of a passive connection in its kinematic circuit is proposed. This design of the machine is realized due to the introduction into the kinematic circuit of an additional moving link – the second working capacity. Operation of this design of the car allows to increase productivity of processing of details considerably due to the fact that there is a possibility on one car to carry out two different technological operations at the same time or to process two parties of various details at the same time. The principle of operation of the mechanism and the machine is described. Analytical researches of the basic geometrical and constructive parameters of the galvanizing machine with two working capacities which, as a whole, provide its rational functioning are executed. The relationship between the geometric parameters of the moving parts of the machine and the change in the amplitude of their movements. In particular, mathematical dependences are obtained, which make it possible to calculate the amplitude of the angle change between the axes of two tanks, as well as the amplitude of the distance change between mutually perpendicular geometric axes of the forks to the working tanks. The operation of this machine design will significantly increase the productivity of machining parts due to the fact that it is possible to perform two different technological operations on one machine or simultaneously process two batches of different parts. The obtained results of analytical researches can be used in the corresponding design bureaus of the machine-building enterprises at a stage of designing of the galting equipment with difficult spatial movement of working capacities.
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Magrey, M., M. Jain, R. Ranza, J. Stigler, E. Mcdearmon-Blondell, C. Yue, B. Padilla, C. Kaufmann, and D. Mcgonagle. "POS1057 IMPACT OF RISANKIZUMAB ON ENTHESITIS AND ASSOCIATED PAIN: POOLED RESULTS FROM THE PHASE 3, RANDOMIZED, DOUBLE-BLIND KEEPsAKE 1 AND 2 TRIALS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 849–50. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3161.
Full textAbstract:
BackgroundControlling or improving musculoskeletal disease activity of psoriatic arthritis (PsA) (eg, enthesitis and associated pain) is a treatment priority for patients, rheumatologists, and dermatologists.1 Enthesitis is the cardinal lesion in PsA and is immunogenetically and experimentally linked to the interleukin-23 (IL-23) pathway.2 Risankizumab (RZB), a humanized immunoglobulin G1 monoclonal antibody that specifically inhibits IL-23 by binding to its p19 subunit, was studied in a phase 3 adult PsA program (KEEPsAKE clinical trials).3,4 Pooled analyses from the program demonstrated the efficacy of RZB to treat enthesitis and pain associated with PsA, and increase the proportion of patients whose enthesitis resolved compared with placebo (PBO) in those patients who had an inadequate response or intolerance to ≥1 conventional synthetic disease-modifying antirheumatic drugs (KEEPsAKE 1 and 2) and/or ≤ 2 biological therapies (KEEPsAKE 2).ObjectivesTo investigate whether patients without enthesitis at baseline (BL) (Leeds Enthesitis Index [LEI] = 0 at BL) remained enthesitis-free through week (W) 52, patients with enthesitis at BL (LEI > 0 at BL) had resolution of enthesitis through W52, and if greater pain relief was achieved with RZB 150 mg in patients with enthesitis at BL vs PBO up to W24.MethodsThe study design and primary results of KEEPsAKE 1 (NCT03675308) and KEEPsAKE 2 (NCT03671148) have been previously reported.3,4 Briefly, patients were randomized to receive RZB 150 mg or PBO subcutaneously at weeks 0, 4, and 16 during a 24-week, double-blind treatment period; at W28 all patients received open label RZB 150 mg. For this post hoc analysis, the RZB 150 mg and PBO groups were pooled across the 2 studies. Pain reductions (as measured by change from BL in visual analogue scale [VAS] scores) were assessed at each time point through W24 among patients with enthesitis at BL (LEI > 0 at BL) using mixed-effect model repeated measurement analysis. Additional enthesitis analyses were calculated on the data as observed.ResultsAcross the pooled population, over 60% of patients in each treatment group had enthesitis at BL (RZB=444/707 [63%]; PBO=448/700 [64%]). Conversely, 37% (263/707) and 36% (252/700) had no enthesitis (LEI=0) at BL among those randomized to RZB and PBO, respectively. Among enthesitis-free patients at BL (LEI=0 at BL), 84.7% on PBO and 90% on RZB remained free of enthesitis through W24; by W52, approximately 93% of patients in both groups (RZB and PBO to RZB) remained enthesitis free. A numerically higher proportion of patients with enthesitis at BL (LEI > 0 at BL) treated with RZB (52.1%) achieved an enthesitis-free state at W24 vs PBO (41.8%); similar proportions achieved an enthesitis-free state at W36 and W52 during open label treatment (Figure 1). Among patients with enthesitis at BL, a significantly greater improvement in VAS pain scores was observed in patients treated with RZB 150 mg vs PBO, as early as W4 (P < .01) and increased through W24 (Figure 1; P < .001).Figure 1.ConclusionLong-term maintenance of an enthesitis-free state (LEI = 0) was similar between the RZB 150 mg and PBO groups, with approximately 93% of patients remaining free of enthesitis at W52. For LEI > 0 patients, the RZB 150-mg group had numerically more patients whose enthesitis resolved at W24, and similar proportions were observed at W52 after the open label switch. Patients with enthesitis at BL treated with RZB 150 mg had statistically greater improvements in pain compared with patients taking PBO starting at W4 through to W24.References[1]Orbai A-M, et al. Ann Rheum Dis. 2017;76:673–680.[2]Stavre Z, et al. Arthritis Res Ther. 2022;24(1):24.[3]Kristensen LE, et al. Ann Rheum Dis. 2021;0:1–7.[4]Östör A, et al. Ann Rheum Dis. 2021;0:1–8.AcknowledgementsAbbVie Inc. participated in the study design; study research; collection, analysis, and interpretation of data; and writing, reviewing, and approving this abstract for submission. All authors had access to the data; participated in the development, review, and approval of the abstract; and agreed to submit this abstract to EULAR 2022 for consideration as a poster or oral presentation. No honoraria or payments were made for authorship. AbbVie and the authors thank all study investigators for their contributions and the patients who participated in this study. AbbVie funded the research for this study and provided writing support for this abstract. Medical writing assistance, funded by AbbVie, was provided by Kersten Reich, MPH, and Nancy Niguidula, DPH, of JB Ashtin.Disclosure of InterestsMarina Magrey Consultant of: MM has received consulting fees from UCB, Novartis, Eli Lilly, Pfizer, and Janssen., Grant/research support from: MM received research grants from Amgen, AbbVie, and UCB Pharma, Manish Jain Consultant of: MJ received consulting fees from Amgen, Abbvie, Eli Lilly, Pfizer, and Novartis., Grant/research support from: MJ received research support from Amgen, Abbvie, Eli Lilly, Pfizer, and Novartis., R Ranza Speakers bureau: RR is a member of speaker bureaus for AbbVie, Janssen, Novartis, and Pfizer, Consultant of: RR is a consultant for AbbVie, Janssen, Novartis, and Pfizer, Jayne Stigler Shareholder of: JS may hold AbbVie stock or stock options., Employee of: JS is a full-time employee of AbbVie., Erin McDearmon-Blondell Shareholder of: EMB may hold AbbVie stock or stock options., Employee of: EMB is a full-time employee of AbbVie., Cuiyong Yue Shareholder of: CY may hold AbbVie stock or stock options., Employee of: CY is a full-time employee of AbbVie., Byron Padilla Shareholder of: BP may hold AbbVie stock or stock options., Employee of: BP is a full-time employee of AbbVie., Christian Kaufmann Shareholder of: CK may hold AbbVie stock or stock options., Employee of: CK is a full-time employee of AbbVie., Dennis McGonagle Speakers bureau: DM is a member of speaker bureaus for AbbVie, Janssen, Novartis, and Pfizer., Grant/research support from: DM received research grants from AbbVie, Janssen, Novartis, and Pfizer, UCB, BMS, Celgene.
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Ruperto, N., G. Schulert, A. Sproles, S. Thornton, G. Vega Cornejo, J. Anton, R. Cuttica, et al. "POS0076 S100A8/A9 AND S100A12 AS POTENTIAL PREDICTIVE BIOMARKERS OF ABATACEPT RESPONSE IN POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 245–46. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1081.
Full textAbstract:
Background:The calcium-binding proteins S100A8/A9 (calprotectin) and S100A12 (extracellular newly identified receptor for advanced glycation end-products binding protein [EN-RAGE]) are involved in multiple signalling pathways to mediate inflammation, can be secreted by activated monocytes/macrophages and exhibit cytokine-like extracellular functions. Circulating levels of these proteins have been associated with disease and clinical responses in systemic juvenile idiopathic arthritis (sJIA), including treatment response.1 Studies suggest that serum S100A8/A9 and S100A12, which are released at inflammation sites, are more specific biomarkers of local inflammation (e.g. in the synovium) than systemic biomarkers such as CRP and ESR.2,3Objectives:To investigate if baseline S100A8/A9 and S100A12 predict clinical response to abatacept treatment in polyarticular JIA (pJIA), and to assess whether changes from baseline in S100A8/A9 or S100A12 can be better prognostic markers for response to abatacept treatment than CRP in pJIA.Methods:Data are from a phase III trial of SC abatacept for the treatment of pJIA (NCT01844518).4 This 24-month, single-arm, open-label, international, multicentre, two-part study included male and female patients with pJIA aged 2–17 years. This analysis examined the correlation between biomarkers (S100A8/A9, S100A12 and high-sensitivity CRP [hsCRP]) and disease activity (measured using Juvenile Arthritis Disease Activity Score [JADAS]) at baseline, baseline biomarker values as predictors of future treatment response (ACR and JADAS endpoints), and the correlation between change from baseline in biomarker values and treatment response at Day 113.Results:Of 219 total patients, 158 (72%) had S100A8/A9 values and 155 (71%) had S100A12 values at baseline. Median S100A8/A9 and S100A12 values were 3295 ng/mL (normal range, 716–3004 ng/mL) and 176 ng/mL (normal range, 32–385 ng/mL), respectively. S100A8/A9, S100A12 and hsCRP (median 0.20 mg/dL; normal ≤0.6 mg/dL) had a low-to-moderate but significant association with disease activity at baseline; coefficients for associations between JADAS71-CRP low disease activity (LDA) and the biomarkers S100A8/A9, S100A12 and hsCRP were 0.23 (p=0.0038), 0.16 (p=0.0448) and 0.26 (p=0.0001), respectively. Baseline S100A8/A9 level above the median was associated with lower odds of ACR100 at Day 113 (p=0.0052). Figure 1 shows the associations of baseline biomarker values with Day 113 ACR and JADAS scores in the overall population. Baseline S100A8/A9 or S100A12 did not significantly influence ACR50 or ACR70 responses at Day 113, but high baseline values were associated with reduced odds of ACR90 (p=0.01), ACR100 (p=0.005), ACR-inactive disease (ID) (p=0.0001), and JADAS71-CRP (LDA) (p=0.02). By Day 477, elevated baseline S100A12 was still significantly associated with lower odds of ACR100 overall (0.467; p=0.0248) but baseline S100A8/A9 was not; at Day 645, neither was significantly associated with ACR100 response. At Day 113, changes from baseline in S100A8/A9 and S100A12 were correlated with ACR100 (coefficients of 0.22 [p=0.0082] and 0.26 [p=0.0015], respectively) and with ACR-ID (0.22 [p=0.0067] and 0.26 [p=0.0014], respectively); change in hsCRP was not significantly correlated with disease response.Conclusion:S100A8/A9 and S100A12 may serve as prognostic biomarkers to predict response to abatacept treatment at Day 113. Changes from baseline S100A8/A9 and S100A12 levels were more highly correlated with efficacy outcomes including ACR100 and ACR-ID at Day 113 compared with hsCRP.References:[1]Aljaberi N, et al. Pediatr Rheumatol Online J 2020;18:7.[2]Hammer H, et al. Arthritis Res Ther 2011;13:R178.[3]Nordal HH, et al. BMC Musculoskelet Disord 2014;15:335.[4]Brunner H, et al. Arthritis Rheumatol 2018;70:1144–1154.Acknowledgements:Professional medical writing and editorial assistance was provided by Rob Coover, MPH, at Caudex and was funded by Bristol Myers Squibb.Disclosure of Interests:Nicolino Ruperto Speakers bureau: NR has received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, Astrazeneca-Medimmune, Bayer, Biogen, Boehringer, Bristol Myers Squibb, Celgene, Eli Lilly, EMD Serono, GlaxoSmithKline, Hoffmann-La Roche, Janssen, Merck, Novartis, Pfizer, R-Pharma, Sinergie, Sobi and UCB, Consultant of: NR has received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, Astrazeneca-Medimmune, Bayer, Biogen, Boehringer, Bristol Myers Squibb, Celgene, Eli Lilly, EMD Serono, GlaxoSmithKline, Hoffmann-La Roche, Janssen, Merck, Novartis, Pfizer, R-Pharma, Sinergie, Sobi and UCB, Grant/research support from: The IRCCS Istituto Giannina Gaslini (IGG), where NR works as full-time public employee has received contributions (>10.000 USD each) from the following industries in the last 3 years: Bristol Myers Squibb, Eli Lilly, F Hoffmann-La Roche, GlaxoSmithKline, Janssen, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties., Grant Schulert Speakers bureau: Novartis, Consultant of: SOBI, Alyssa Sproles: None declared, Sherry Thornton: None declared, Gabriel Vega Cornejo Speakers bureau: AbbVie, Grant/research support from: Bristol Myers Squibb, Eli Lilly, Janssen, Parexel, Sanofi, Jordi Anton Speakers bureau: AbbVie, Gebro, GlaxoSmithKline, Novartis, Pfizer, Roche, Sobi, Consultant of: AbbVie, Gebro, GlaxoSmithKline, Novartis, Pfizer, Roche, Sobi, Grant/research support from: AbbVie, Amgen, Gebro, GlaxoSmithKline, Lilly, Novartis, Novimmune, Pfizer, Roche, Sanofi, Sobi, Ruben Cuttica Speakers bureau: AbbVie, Bristol Myers Squibb, GlaxoSmithKline, Lilly, Novartis, Pfizer, Roche, UCB, Paid instructor for: AbbVie, Novartis, Pfizer, Roche, Consultant of: AbbVie, Bristol Myers Squibb, GlaxoSmithKline, Lilly, Novartis, Pfizer, Roche, UCB, Michael Henrickson: None declared, Ivan Foeldvari Consultant of: Bristol Myers Squibb, Gilead, Hexal, MEDAC, Novartis, Pfizer, Sanofi, Daniel Kingsbury Consultant of: Pfizer, Margarita Askelson Consultant of: Currently working for Syneos Health providing services to Bristol Myers Squibb, Jinqi Liu Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Sumanta Mukherjee Shareholder of: Bristol Myers Squibb, GlaxoSmithKline, Employee of: Bristol Myers Squibb, GlaxoSmithKline, Robert Wong Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Daniel J Lovell Speakers bureau: Genentech, Wyeth Pharm, Consultant of: Abbott, Amgen, AstraZeneca, Boehringer Ingelheim, Celgene, GlaxoSmithKline, Hoffman-La Roche, Novartis, Pfizer, Regeneron, Takeda, UBC, Wyeth Pharma, Xoma, Alberto Martini Speakers bureau: AbbVie, Novartis, Consultant of: AbbVie, Eli Lilly, EMD Serono, Idorsia, Janssen, Novartis, Pfizer, Alexei Grom Consultant of: AB2Bio, Novartis, Sobi (NovImmune), Grant/research support from: AB2Bio, Novartis, Sobi (NovImmune), Hermine Brunner Speakers bureau: GlaxoSmithKline, Novartis, Pfizer, Roche, Paid instructor for: Novartis, Pfizer (funds go to CCHMC/employer), Consultant of: Boehringer Ingelheim, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Merck, Novartis, Pfizer, Roche, UCB (funds go to CCHMC/employer), Grant/research support from: Bristol Myers Squibb, Pfizer (funds go to CCHMC/employer).
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Boshkova, Irina, and Ihor Mukminov. "Mathematical modeling of the heat transfer process in a dense blown layer of granular material." ScienceRise, no. 6 (December 30, 2022): 10–17. http://dx.doi.org/10.21303/2313-8416.2022.002825.
Full textAbstract:
The object of research: a mathematical model of unsteady heat transfer between particles forming a dense layer in a heat exchange channel and an air flow passing through the layer.
Investigated problem: obtaining a mathematical model adequate to the physical phenomenon will significantly expand the field of research, reduce the time for determining the thermal characteristics of heat transfer and data processing.
The main scientific results: an explicit analytical dependence is obtained that allows calculating the local temperature of the layer in an arbitrary cross-section of the channel at selected moments of time. The presented analytical dependence was verified by analyzing the calculated data on the material temperatures in the channel obtained by varying the main physical quantities: the effect of the heating duration, heat transfer coefficient, porosity, and density on the temperature distribution was studied. The temperatures along the length of the channel were calculated at different points in time with the following initial data: material - gravel: c=860, ρ=1500, λ=0.6, ε=0.4; aud=800. Based on the results of the calculations for the time τ=60 s, τ=900 s, τ=1800 s, τ=2400 s, τ=1800 s, the graphs shown in the paper are constructed. It is shown that the mathematical model adequately describes the process of heating a layer of granular material in a heat exchange channel and allows obtaining satisfactory data on the temperature distribution along the length at different points in time. The calculated data correlate satisfactorily with the experimental results.
Innovative technological product is an analytical dependence obtained for the first time, which is necessary for inclusion in the calculation method of regenerative heat exchangers intended for the utilization of low-potential heat flows.
The area of practical use of the research results is the heat engineering calculations of regenerative heat exchangers with a dense granular packing. The consumers of the developed regenerators are greenhouses and food industry. Such industries are characterized by a low-potential level of thermal emissions, the heat of which is difficult to utilize using existing heat exchange equipment.
Scope of the innovative product: design bureaus focused on the design of innovative heat exchangers for the utilization of low-potential heat flows, and research laboratories studying the processes of heat exchange between a dense layer of granular material and a through gas (air) flow.
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Lee, Mordecai. "Information Is Power: Women as Information Providers to the President’s Budgeting Men; A History of the Bureau of the Budget Library, 1940-1970." Public Voices 14, no. 2 (January 5, 2017): 85. http://dx.doi.org/10.22140/pv.12.
Full textAbstract:
Quietly tucked within the elite agency exercising the president’s power of the purse was a little-known in-house library. Given that information is power, the women of the library of the US Bureau of the Budget collected, cataloged and disseminated information to the bureau’s male budgeteers. This article traces the history of the budget bureau’s library, which has been largely overlooked in the literature, including the extended career of its chief administrator, Ruth Fine, who headed it from 1940 to 1972. Starting her career during the era of the “spinster librarian” and anti-Semitism in the professions, she rose to have a long-time management career as the Bureau’s library director.
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Liu, Haiyan, Kangning Xiong, Yanghua Yu, Tingling Li, Yao Qing, Zhifu Wang, and Shihao Zhang. "A Review of Forest Ecosystem Vulnerability and Resilience: Implications for the Rocky Desertification Control." Sustainability 13, no. 21 (October 27, 2021): 11849. http://dx.doi.org/10.3390/su132111849.
Full textAbstract:
With a changing climate and socio-economic development, ecological problems are increasingly serious, research on ecosystem vulnerability and ecological resilience has become a hot topic of study for various institutions. Forests, the “lungs of the earth”, have also been damaged to varying degrees. In recent years, scholars have conducted numerous studies on the vulnerability and resilience of forest ecosystems, but there is a lack of a systematic elaboration of them. The results of a statistical analysis of 217 related documents show: (1) the number of studies published rises wave upon wave in time series, which indicates that this area of study is still at the stage of rising; (2) the research content is concentrated in four dimensions—ecosystem vulnerability assessment, ecosystem vulnerability model prediction, ecological resilience, and management strategies—among which the ecosystem vulnerability assessment research content mainly discusses the evaluation methods and models; (3) the research areas are mainly concentrated in China and the United States, with different degrees of distribution in European countries; and (4) the research institutions are mainly the educational institutions and forestry bureaus in various countries. In addition, this paper also reveals the frontier theory of forest ecosystem vulnerability and resilience research from three aspects—theoretical research, index system, and technical methods—puts forward the problems of current research, and suggests that a universally applicable framework for forest ecosystem vulnerability and resilience research should be built in the future, and theoretical research should be strengthened to comprehensively understand the characteristics of forest ecosystems so that sustainable management strategies can be proposed according to local conditions.
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Popovych, Olexandr S. "THE PATON MANEUVER IN THE HISTORY OF THE NAS OF UKRAINE." Visnik Nacional'noi' academii' nauk Ukrai'ni, no. 11 (November 20, 2020): 59–65. http://dx.doi.org/10.15407/visn2020.11.059.
Full textAbstract:
The article highlights the specific features of the development of the NAS of Ukraine related to the activities of B.Ye. Paton after his election as president of the Academy. It is shown that the implementation of the course announced by him to strengthen the links between science and industry and accelerate the practical use of research and development results in the national economy has allowed to almost double the total funding of the Academy by attracting customers. At the same time, its structure changed dramatically: along with new scientific institutes, design and technological bureaus, research plants, powerful scientific and technological complexes and engineering centers were created. The material and technical base of scientific research has been significantly strengthened, two academy towns have been created, numerous institute buildings and large volumes of housing for the Academy's employees have been built. It is significant that all this took place in the so-called “period of stabilization of science”, when the vast majority of research centers and branches of the USSR Academy of Sciences and academies of sciences of the union republics did not have the opportunity to develop in this way. This specificity of the development of the Ukrainian Academy is due to the initiative of its president, Academician B.Ye. Paton and his perseverance in implementing this course. The article uses materials from official statistics, supplemented by the author's impressions and observations, because he observed these processes both from within, working at the NAS of Ukraine, and from outside, visiting most research centers and branches of the USSR Academy of Sciences.
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Pisani, Donald J. "Federal Reclamation and the American West in the Twentieth Century." Agricultural History 77, no. 3 (July 1, 2003): 391–419. http://dx.doi.org/10.1215/00021482-77.3.391.
Full textAbstract:
Abstract "Federal Reclamation and the American West in the Twentieth Century" looks at four phases in the history of the Bureau of Reclamation. The first phase lasted from the adoption of the Reclamation Act of 1902 into the 1930s. In those years, the bureau attempted to create small family farms by bringing water to the desert lands of the West. That effort failed, in part because farming was becoming less attractive in the United States during the early decades of the 20th century, in part because irrigation was too expensive, and in part because the bureau made many mistakes in administering the 30 projects it created. A second phase of the bureau’s life began in the 1930s, with the "high dam era." From 1930 into the 1950s, the bureau’s mission became inconsistent as it strived to serve a new constituency, city dwellers and industries on the Pacific Coast, at the same time it continued to push the family farm. The bureau entered a third phase of life after World War II, when the power it generated became identified with winning the Cold War against the Soviet Union and agribusiness eclipsed the family farm in the West. Finally, once big dams began to look too expensive and like "old technology," the bureau recreated itself into an agency which now claims to work in the interest of protecting the environment and serving as the West’s "water broker." The Bureau of Reclamation, which has done as much as any federal agency to build the modern American West, has shown an amazing ability to pursue inconsistent objectives and to recreate itself.
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Giancane, G., R. Papa, S. Vastert, F. Bagnasco, J. F. Swart, P. Quartier, M. Hofer, et al. "OP0164 LONG-TERM SAFETY OF ANAKINRA IN PATIENTS WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS FROM THE PHARMACHILD REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 98.2–99. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1731.
Full textAbstract:
Background:Systemic juvenile idiopathic arthritis (SJIA) is characterized by extra-articular manifestations, as fever and rash, and rarely associated by a potentially lethal complication as macrophage activation syndrome (MAS). Anakinra is a recombinant human interleukin (IL)-1 receptor antagonist whose efficacy and safety profile has been studied for patients with SJIA.Objectives:To evaluate the long-term safety profile of anakinra in patients with SJIA.Methods:Data from patients with SJIA enrolled in the Pharmachild registry before 30 September 2018 and treated with anakinra were analyzed. The study endpoints were the occurrence of non-serious adverse events (AEs) of at least moderate severity and serious AEs (SAEs), including macrophage activation syndrome (MAS), and the duration of anakinra treatment with reasons for discontinuation. All endpoints were analyzed overall, by 6 month-time windows and in different treatment sets represented by those patients continuously treated with anakinra for at least 12, 18 and 24 months (set-12, -18, -24, respectively).Results:306 patients were enrolled. 46%, 34% and 28% of them had been treated for at least 12, 18 and 24 months, respectively. 201 AEs, mostly represented by infections, were reported for 509.3 patient-years (py) with an overall incidence rate (IR) of 39.5/100 py. Among 56 SAEs (IR 11.0/100 py), (Table 1) 23.2% were infections and 19.6% MAS episodes. The IR of AEs was higher during the first 6 months of anakinra, followed by decreasing IR in the different long-term treatment sets. Treatment discontinuation occurred in 76% of patients, most in the first 6 months, due to inefficacy (43%), remission (31%) or AEs/intolerance (15%). No deaths or malignancies occurred during anakinra treatment.Table 1.Number of SAEs and incidence rates (95% CI) by overall PT decreasing order and time window in the complete set (events with a frequency >1 by overall SOC and >1 by overall PT were reported) Only time windows <13 months were reported in the present table.Time window1-6 months7-12 monthsOverallN306194306Patient-time (years)117.380.2509.3SOCPTnRate (95% CI)nRate (95% CI)nRate(95% CI)AllAll3328.1 (19.1-41.5)45.0 (1.9-13.2)5611.0 (7.9-15.2)Infections and infestationsAll76.0 (2.9- 12.4)11.2 (0.2- 8.8)132.6 (1.4- 4.8)Pneumonia21.7 (0.4- 6.8)11.2 (0.2- 8.8)40.8 (0.3- 2.1)Immune system disordersAll76.0 (2.8- 12.5)11.2 (0.2- 8.8)112.2 (1.1- 4.1)Haemophagocytic lymphohistiocytosis76.0 (2.8- 12.5)11.2 (0.2- 8.8)112.2 (1.1- 4.1)Injury, poisoning and procedural complicationsAll54.3 (1.8- 10.2)--91.8 (0.9- 3.4)Infusion related reaction10.9 (0.1- 6.0)--20.4 (0.1- 1.6)Injection related reaction43.4 (1.3- 9.1)--61.2 (0.5- 2.6)Metabolism and nutrition disordersAll32.6 (0.8- 7.9)--40.8 (0.3- 2.1)Skin and subcutaneous tissue disordersAll32.6 (0.8- 7.9)11.2 (0.2- 8.8)40.8 (0.3- 2.1)Blood and lymphatic system disordersAll10.9 (0.1- 6.1)--20.4 (0.1- 1.6)General disorders and administration site conditionsAll10.9 (0.1- 6.1)11.2 (0.2- 8.8)20.4 (0.1- 1.6)InvestigationsAll21.7 (0.4- 6.8)--20.4 (0.1- 1.6)Nervous system disordersAll10.9 (0.1- 6.0)--20.4 (0.1- 1.6)Surgical and medical proceduresAll10.9 (0.1- 6.0)--20.4 (0.1- 1.5)Abbreviations: SAE, serious adverse event; SOC, system organ class; PT, preferred term, MedDRA version 21.1; N, number of patients ever treated with anakinra during the time window irrespectively of the length of any unexposed periods; 95% CI, 95% Confidence Interval.Conclusion:The results of the present study confirm the long-term safety profile of anakinra in SJIA patients and show a decreasing overall incidence rate of AEs over time.Disclosure of Interests:Gabriella Giancane Grant/research support from: The study was funded by SOBI Swedish, Riccardo Papa Grant/research support from: The study was funded by SOBI Swedish, Sebastian Vastert Grant/research support from: The study was funded by SOBI Swedish, Francesca Bagnasco Grant/research support from: The study was funded by SOBI Swedish, Joost F. Swart Grant/research support from: The study was funded by SOBI Swedish, Pierre Quartier Grant/research support from: The study was funded by SOBI Swedish, michael hofer Grant/research support from: The study was funded by SOBI Swedish, Jordi Anton Grant/research support from: The study was funded by SOBI Swedish, Sylvia Kamphuis Grant/research support from: The study was funded by SOBI Swedish, Helga Sanner Grant/research support from: The study was funded by SOBI Swedish, Mia Glerup Grant/research support from: The study was funded by SOBI Swedish, Fabrizio De Benedetti Grant/research support from: The study was funded by SOBI Swedish, Elena Tsitsami Grant/research support from: The study was funded by SOBI Swedish, Agustin Remesal Grant/research support from: The study was funded by SOBI Swedish, Estefania Moreno Ruzafa Grant/research support from: The study was funded by SOBI Swedish, Jaime de Inocencio Grant/research support from: The study was funded by SOBI Swedish, Charlotte Myrup Grant/research support from: The study was funded by SOBI Swedish, Chiara Pallotti Grant/research support from: The study was funded by SOBI Swedish, Isabelle Koné-Paut Grant/research support from: The study was funded by SOBI Swedish, Karin Franck-Larsson Employee of: I am employee of SOBI pharmaceutical company, Hakan Malmstrom Employee of: I am employee of SOBI pharmaceutical company, Susanna Cederholm Employee of: I am employee of SOBI pharmaceutical company, Angela Pistorio Grant/research support from: The study was funded by SOBI Swedish, Nico Wulffraat Grant/research support from: The study was funded by SOBI Swedish, Nicolino Ruperto Speakers bureau: NR has received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, Astrazeneca-Medimmune, Bayer, Biogen, Boehringer, Bristol Myers and Squibb, Celgene, Eli-Lilly, EMD Serono, Glaxo Smith and Kline, Hoffmann-La Roche,Janssen, Merck, Novartis, Pfizer, R-Pharma, Sinergie, Sobi and UCB., Consultant of: NR has received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, Astrazeneca-Medimmune, Bayer, Biogen, Boehringer, Bristol Myers and Squibb, Celgene, Eli-Lilly, EMD Serono, Glaxo Smith and Kline, Hoffmann-La Roche,Janssen, Merck, Novartis, Pfizer, R-Pharma, Sinergie, Sobi and UCB., Grant/research support from: The IRCCS Istituto Giannina Gaslini (IGG), where NR works as full-time public employee has received contributions (> 10.000 USD each) from the following industries in the last 3 years: BMS, Eli-Lilly, GlaxoSmithKline, F Hoffmann-La Roche, Janssen, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties.
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Marsden, B. G. "6. Astronomical Telegrams (Telegrammes Astronomiques) (Committee of the Executive Committee)." Transactions of the International Astronomical Union 21, no. 1 (1991): 13–14. http://dx.doi.org/10.1017/s0251107x00009755.
Full textAbstract:
The year 1990, within the triennium covered by the present report, marked a number of significant anniversaries for the Central Bureau, including 70 years since its foundation at the Brussels Observatory, 25 years since the transfer of the Bureau’s operations to the Smithsonian Astrophysical Observatory (and 22 years of Dr. Marsden’s service as Director), and the issuance of the 5000th Circular. The amount of work done at the Bureau has increased enormously in this time, but especially within the past decade, as a result of the demands of modern astronomers and astrophysicists who are responding to the technological advances that have revolutionized observing and computing methods. At the same time methods of rapid communication have undergone a transformation that still continues. Appreciation is due for the support provided to the Bureau by the Smithsonian Astrophysical Observatory, but special gratitude must be expressed to Dr. Marsden and members of the staff and volunteers for their long hours of work and dedication to the needs of astronomers around the world for rapid access to information.