Dissertations / Theses on the topic 'Thrombosis'
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Echenique, Javier Jacobo. "Thrombotic fingerprints for the enhanced prediction of thrombosis." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39880.
Full textIncludes bibliographical references (leaves 111-114).
Controlled thrombosis initiates and regulates tissue repair and remodeling in the vessel wall. Processes from heart attack to stroke, and deep vein thrombosis to pulmonary embolism, are all derived from unrestricted clotting. The frustrating aspects of these diseases lie not only in the difficulty of their timely diagnosis, but in the selection of appropriate therapy, titration of intervention, and identification of patients at risk. Assays like the INR, PTT, and ACT can follow the course of specific pathways that govern activation of specific coagulation factors or platelet function, but they do not provide the insight into mechanism, risk and potential therapeutic benefit. We posit that elucidation of the complex dynamics of clot generation requires an integrated assessment that takes into account all of the factors driving thrombosis simultaneously. Virchow's Triad, has for years been identified as the three critical parameters of clot formation. We propose to examine an individual's clot propensity and response to therapy on minute blood samples, in virtual real time, across a range of flow rates, blood state, and wall conditions with the use of our newly developed in vitro high-throughput testing device.
(cont.) In this manner we will generate a unique thrombotic fingerprint that defines an individual's risk of clotting at a specific point in time over a range of stresses. This fingerprint can aid in tailoring therapeutic clinical treatments, determining the duration and dose of therapy, and assist in clinical trial management and establishment of clinical norms.
by Javier Jacobo Echenique.
S.M.
Mendez, Rojano Rodrigo. "Thrombosis modeling in blood coated medical devices." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTS088/document.
Full textThrombosis, which is the formation of a blood clot (thrombus) in the vascular system, is one of the major issues of blood-coated medical devices. To reduce thrombosis risk in this type of devices, computational fluid dynamics has been used. Up to date, bio-material surfaces used in blood coated devices initiate blood coagulation through the contact activation system. This system has not been considered in models dedicated to devices, even though its importance in thrombosis has been recently highlighted. The objective of this thesis is to introduce device-triggered coagulation reactions in the modeling of device-related thrombosis.A novel reduced kinetic model including the contact activation system is proposed. The model correctly captures thrombin formation in physiological and prothrombin deficient platelet-poor-plasma. The reduced set of reactions is then included in a platelet-based model for thrombus formation considering platelet activation by thrombin. This approach is used to study thrombus formation in an academic configuration
Bark, David Lawrence Jr. "The hemodynamics during thrombosis and impact on thrombosis." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37258.
Full textMaclean, Jessica Amy Ann. "Novel approaches to enhance the thrombolytic potential of tissue plasminogen activator (tPA) therapy in stroke." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23147.
Full textLandskroner, Kyle Alan. "Thrombosis and Thrombolysis: Emphasis on Hemophilia and Effect of Clot Dissolution with Plasmin." NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-08142005-145317/.
Full textClouston, Hamish. "Thrombosis in colorectal cancer." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/thrombosis-in-colorectal-cancer(43d5ef8e-6c59-4fc6-b02c-695898e634d5).html.
Full textBruce, David. "Antithrombin : structural variants and thrombosis." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386084.
Full textGray, E. "Lipoproteins, blood coagulation and thrombosis." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372834.
Full textSaraf, Smriti. "Assessment of thrombotic and thrombolytic status in patients with coronary artery disease and its relation to clinical outcomes." Thesis, University of Hertfordshire, 2014. http://hdl.handle.net/2299/15000.
Full textWootton, David MacMullen. "Mechanistic modeling of occlusive arterial thrombosis." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/17351.
Full textBrown, John Gordon. "A study of deep venous thrombosis." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303015.
Full textDarbousset, Roxane. "Roles of polymorphonuclear neutrophils in thrombosis." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5071.
Full textHemostasis is a physiological process to preserve the integrity of the vascular system and to prevent blood loss in response to injury. In pathological conditions, such as cancers, infections or cardiovascular diseases, the blood coagulation cascade can be activated, leading to the formation of a platelet thrombus.Using a laser-injury model coupled with a high-definition, high-speed camera, we explored the cellular and molecular mechanisms involved in thrombus formation in physiological and in pathological conditions associated with the development of a cancer. The first part of this work describes the role of polymorphonuclear neutrophils (PMNs) in thrombus formation. We show that PMNs are the first cells to accumulate at the site of injury and represent the main source of blood-borne tissue factor (TF), leading to the generation of fibrin and thrombus formation. We also show that once present at the site of injury, PMNs recruit Endothelial Progenitor Cells (endothelial colony-forming cells, ECFCs), which play a key role in vascular repair. The second part of this work we determined, in dedicated mouse models, the involvement of TF and platelet activation in thrombosis associated with cancer. Together, our findings provide new perspectives in the understanding of the pathophysiological role of polymorphonuclear neutrophils, Endothelial Progenitor Cells and platelets
Pépin, Marion. "Caractérisation de nouveaux médiateurs entre cancer, inflammation et thrombose : ADAMTS13, PSGL-1 et Siglec-5." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS571/document.
Full textCancer and thrombosis are frequent and serious concerns in human pathology and public health. This conditions are known to share closed relationships, and reciprocal promotion involving cellular interactions and complex molecular mechanisms. Molecular pathways often involve hemostasis or immunity actors and participate in inflammation process, which can be either cause or consequence. Improved knowledge on molecular mediators at the crossroads of hemostasis and inflammation may allow best understanding of these mechanisms and improving therapeutic management.Thus, we studied Willebrand factor / ADAMTS13 couple : a key protein in hemostasis whose rate is influenced by inflammatory processes and its regulatory protease. This study in cancer patients shows that Willebrand factor and ADAMTS13 could be used as biomarkers to predict individual thrombosis risk and thus improve therapeutic management. Precise role of this proteins in cancer-mediated thrombosis remain unexplored.Furthermore, we hypothesized an interaction between two leukocyte receptors : PSGL-1(P-selectin glycoprotein ligand-1) and Siglec-5. Leukocytes, especially neutrophils are recruited to inflammation sites after a key step of rolling along vasculature. PSGL-1 expressed on the majority of leukocytes is P-selectin ligand and plays a major role in leukocyte rolling. PSGL-1 has a structure rich in sialic acids. Siglec-5 is an immunoglobulin-like receptor and binds sialic acids. Thus, we described and characterized the interaction between these two proteins, and studied its role in leukocyte rolling in vitro and in vivo. Before considering any application, the modalities of this interaction should further analyzed (binding site, etc. ...) and its effect in other mechanism involving PSGL-1/P-selectin interaction like thrombus formation
Galanaud, Jean-Philippe. "Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T027.
Full textBackground: Though they represent the majority of all lower limbs thromboses, isolated distal deep-vein thrombosis (DVT) (without symptomatic pulmonary embolism (PE)) and isolated superficial vein thrombosis (SVT) (without DVT or PE) have been poorly studied. Their clinical significance and management are under debate.Methods: Data from epidemiological multicenter prospective studies OPTIMEV, POST, RIETEResults and comments: Isolated distal DVT: Distal and proximal DVTs exhibit a different risk factor profile, the latter being more associated with chronic risk factors. Three-month mortality of distal DVT patient is lower than that of proximal DVT ones but is higher than that of controls. This evidences that distal DVT is a clinically significant finding. Differences in population profile and outcomes suggests that the benefit/risk ratio of anticoagulant treatment is not similar. Data from proximal DVT clinical trials should no longer be extrapolated to distal DVT.Isolated SVT: In case of SVT the risk of concomitant DVT is high. A compression ultrasonographic exam should be performed and at least explore the whole deep venous system of the affected limb. Male gender and history of DVT/Pulmonary embolism are independent predicators of recurrence. Some SVT can be safely treated without anticoagulants. On contrary, in patients with cancer or a sapheno-femoral junction involvement, the risk of deep venous recurrence is high even upon full therapeutic dose of anticoagulants
Otten, Johannes Martinus Mattheus Bernardus. "Thrombosis and cancer a two way association /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/66385.
Full textTabor, Caroline Mary. "Effects of air pollution on vascular thrombosis." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5577.
Full textWarwick, David John. "Deep vein thrombosis after total hip replacement." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283969.
Full textMartinod, Kim Lindsay. "Neutrophil extracellular traps in thrombosis and inflammation." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13064970.
Full textKhan, Abdullah Rubiat (Emon). "Microparticles and their role in thrombosis in Behçet's Syndrome and their potential as a biomarker for thrombotic risk." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/58996.
Full textGómez, Puerta José Alfredo. "Antiphospholipid Syndrome: Expanding the Spectrum of Autoimmune Thrombosis." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/2227.
Full textThe first study described one of the largest known cohorts of patients with primary APS from 4 different referral centers. The final study sample included 128 patients with primary APS with a median age of 42 years and mean follow-up of 9 years. After a median disease duration of 8.2 years, 110 (86%) patients remained with primary APS; 11 (8%) patients developed SLE; 6 (5%), LLD; and 1 (1%), myasthenia gravis. At the end of the study, 113 (88%) patients were alive and 15 (12%) patients had died. Our study confirms that progression from primary APS to SLE or LLD is unusual, even after a long follow-up.
In the second study, we evaluated 120 cases of antiphospholipid antibodies associated with malignancies with a mean age of 56 years, The main hematological malignancies found were B-cell lymphoma, spleen lymphoma and chronic myeloid leukemia. The main solid tumors were renal cell carcinoma, primary tumor of unknown origin, lung adenocarcinoma and breast carcinoma. Around one third of patients achieved aPL remission after treatment.
In the third study, we analyzed 15 cases of CAPS that appeared during pregnancy or the puerperium with a mean age at the time of the CAPS event of 27 years. In 7 of the 14 (50%) cases, CAPS appeared during pregnancy, in 6 (43%) cases it presented during puerperium and in 1 (7%) after curettage for a fetal death. The main clinical and serological characteristics were similar to those of patients with CAPS triggered by other factors, however we found some particular features including placental infarctions, pelvic vein thrombosis and myometrial thrombotic microangiopathy and HELLP syndrome.
Final conclusion: Primary APS is a widely recognized distinct entity which rarely progresses to SLE, even after long-term follow-up. APS may also be associated with other chronic disorders, such as solid tumors or hematological malignancies. In cases with the life-threatening variant of APS known as CAPS, pregnancy and the puerperium are periods of high susceptibility for the development of this often fatal form of presentation.
"SINDROME ANTIFOSFOLIPIDICO: EXPANDIENDO EL ESPECTRO CLÍNICA DE LA TROMBOSIS AUTOINMUNE"
El síndrome antifosfolipídico (SAF) es un síndrome protrombótico adquirido caracterizado por trombosis venosas y arteriales y pérdidas fetales recurrentes. Puede estar presente como SAF "primario" cuando no esta asociado a ninguna enfermedad autoinmune [fundamentalmente el lupus eritematoso sistémico (LES)] o en asociación a otros procesos tales como infecciones y procesos neoplásicos, entre otros. También puede manifestarse de una forma acelerada en días o semanas, caracterizado por trombosis de pequeños órganos y fallo multiorgánico, lo que se conoce como SAF "catastrófico".
En el primer estudio se analizó una de las series más amplia y con más largo seguimiento de pacientes con SAF primario. Se incluyeron 128 pacientes con un seguimiento medio de 9 años. Después de una duración media de la enfermedad de 8 años, 110 (86%) pacientes continúan con el diagnóstico de SAF primario, 11 (8%) pacientes desarrollaron un LES, 6 (5%) una forma incompleta de lupus ("lupus-like disease") y 1 (1%) paciente desarrolló una miastenia gravis. La presencia del test de Coombs positivo confiere un riesgo estadísticamente significativo para el desarrollo de LES. . Nuestro estudio confirma que es inusual que un SAF primario evolucione hacia un LES o una forma incompleta de lupus, incluso tras un período largo de seguimiento.
En el segundo estudio se incluyeron un total de 120 casos con anticuerpos antifosfolipídicos (AAF) asociados a procesos neoplásicos. Las principales neoplasias hematológicas relacionadas a los AAF fueron el linfoma de células B, el linfoma esplénico y la leucemia mieloide crónica. Los principales tumores sólidos fueron el carcinoma de células renales, los tumores de primario desconocido, el adenocarcinoma de pulmón y el cáncer de mama. Alrededor de una tercera parte de los paciente negativizaron los AAF después del tratamiento de la neoplasia.
En el tercer estudio se analizaron 15 pacientes con SAF catastrófico que ocurrieron durante el embarazo o el puerperio. Las características clínicas generales del SAF catastrófico durante el embarazo o el puerperio fueron similares a las del SAF catastrófico desencadenado por otros factores a excepción de una tasa mayor de abortos previos. Sin embargo se encontraron una serie de características particulares, como el síndrome de HELLP, la trombosis placentaria, la microangiopatía trombótica de miometrio o la trombosis de la vena pélvica.
CONCLUSIÓN FINAL: El SAF primario es una entidad propia ampliamente reconocida que en raras ocasiones evoluciona a un LES, incluso tras un período largo de seguimiento. El SAF puede asociarse a una serie de procesos crónicos como lo son las neoplasias hematológicas y los tumores sólidos. En aquellos casos con la variante "catastrófica" del SAF, el embarazo y el puerperio, constituyen un período de alta susceptibilidad para el desarrollo de esta variante altamente letal del SAF.
Zhang, Yue. "Hemodynamic investigation and thrombosis modeling of intracranial aneurysms." Thesis, Lyon, INSA, 2015. http://www.theses.fr/2015ISAL0081/document.
Full textFeature selection is an important task in data mining and machine learning processes. This task is well known in both supervised and unsupervised contexts. The semi-supervised feature selection is still under development and far from being mature. In general, machine learning has been well developed in order to deal with partially-labeled data. Thus, feature selection has obtained special importance in the semi-supervised context. It became more adapted with the real world applications where labeling process is costly to obtain. In this thesis, we present a literature review on semi-supervised feature selection, with regard to supervised and unsupervised contexts. The goal is to show the importance of compromising between the structure from unlabeled part of data, and the background information from their labeled part. In particular, we are interested in the so-called «small labeled-sample problem» where the difference between both data parts is very important
Wahlgren, Carl Magnus. "Mechanisms of thrombosis and restenosis after vascular injury /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-260-8/.
Full textSmorenburg, Susanna Maria. "Heparins, cancer and thrombosis clinical and experimental studies /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/59625.
Full textKunz, Gabriella. "Thrombomodulin gene mutations and their importance in thrombosis." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248444.
Full textPayne, Holly. "Novel insights into the mechanisms of venous thrombosis." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8172/.
Full textMushunje, Alec. "Antithrombin conformational transitions and their implications in thrombosis." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620006.
Full textBedredinova, V. O. "Absorbable stents for the treatment of vascular thrombosis." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/62808.
Full textHoward, Adam Quentin. "The prevention of post-operative deep vein thrombosis." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/8187.
Full textYamaji, Kyohei. "Bare-metal Stent Thrombosis and In-stent Neoatherosclerosis." Kyoto University, 2012. http://hdl.handle.net/2433/158059.
Full textAuwerda, J. J. A. "Acquired coagulation abnormalities and thrombosis in multiple myeloma." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/14217.
Full textJoshi, Smita. "CONTROLLING PLATELET SECRETION TO MODULATE HEMOSTASIS AND THROMBOSIS." UKnowledge, 2018. https://uknowledge.uky.edu/biochem_etds/37.
Full textOlakareem, Halima. "Prognostic factors associated with the development of post-thrombotic syndrome after a deep vein thrombosis of the lower limb." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7002/.
Full textHouwelingen, Adriana Cornelia van. "Fish against thrombosis? dietary fish and cardiovascular risk profile /." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5411.
Full textBaarslag, Hendrik Jan. "Diagnosis and management of upper extremity deep vein thrombosis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/86567.
Full textJaved, Najma H. "Effects of lupus anticoagulants on thrombosis-related endothelial function." Virtual Press, 1987. http://liblink.bsu.edu/uhtbin/catkey/483176.
Full textWilliams, Christopher M. "Protein kinase Ca in bone eevelopment, thrombopoiesis and thrombosis." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526061.
Full textHitchcock, Jessica Ruth. "Regulation of hepatic inflammation and thrombosis during Salmonella infections." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5119/.
Full textOlsson, Eija. "Acute arterial thrombosis in microsurgery : clinical and experimental studies." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/olsson/.
Full textde, Wet Anna. "Incidence of Deep Vein Thrombosis in the Lower Extremity." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23248.
Full textSimmonds, Rachel Elizabeth. "Protein S deficiency and familial thrombophilia." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267993.
Full textBrown, Anthony James Moginie. "Studies of the molecular structures of the blood coagulation fibrinolytic proteins." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294268.
Full textCasa, Lauren D. C. "Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53540.
Full textKitchen, S. "Laboratory control of anticoagulant therapy : an analysis of current dilemmas; heparin." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299588.
Full textJamieson, Alec. "Assessment of fibrinolytic and antithrombotic activity resulting from modulation of endogenous fibrinolysis in animal models." Thesis, University of Aberdeen, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358267.
Full textAl-Hilali, Mahir Mohamad Ali. "Evaluation of plasminogen function in health and disease." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259938.
Full textRhoné, Benoît. "Étude de la réactivité des uréthanes et polyuréthanes : application aux dispositifs médicaux." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066602/document.
Full textMany implantable medical devices (stents, catheters, cardiac valves…) are used everyday in many domains. The control of the interface between the medical device and the surrounding tissue is still to be improved. Many implanted devices are facing serious complications following implantation such as infections or thrombosis. These problematics are especially present for intravenous catheters used to administrate drugs. In this context, we investigated a way to strongly limit the problematics associated with their implantation, by covalently binding polymers at the surface, to reduce protein adsorption and cell adhesion on the materials used in implantation (polyurethane). The reactivity of urethanes was first studied, it allowed identifying the transcarbamoylation reaction as an efficient tool to modify urethanes and polyurethanes in soft reaction conditions. The reaction of poly (ethylene glycol) and the polyurethane surface, catalyzed by bases, allowed us to get hydrophilic polyurethane surfaces. Modification conditions were optimized to obtain a good covering of the surface with PEG. Surfaces were analyzed: contact angle, profilometry, infrared spectroscopy, XPS and TOF-SIMS. Modified surfaces showed excellent antiadhesive properties with a strong reduction of protein adsorption, cell and bacterial adhesion. The properties of modified surfaces were evaluated and compared to other systems. This strategy of modification is promising to allow one step modification of polyurethane surfaces. In vitro tests show the potential of this surface modification technique to obtain a polyurethane with enhance biocompatibility
MacMeccan, Robert Miles III. "Mechanistic Effects of Erythrocytes on Platelet Deposition in Coronary Thrombosis." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19786.
Full textLane, I. F. "The relationship between platelet-vessel wall interaction thrombosis and atherosclerosis." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233551.
Full textHarrison, Sarah Elinor. "The use of the lattice Boltzmann method in thrombosis modelling." Thesis, University of Sheffield, 2007. http://etheses.whiterose.ac.uk/14507/.
Full textHume, Struan. "Pulsatile Flow in Computational Modelling of Thrombosis in Cerebral Aneurysms." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31581.
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