Journal articles on the topic 'Throat Diseases Treatment'
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Kolesnikova, O. M., S. A. Karpishchenko, and Y. V. Legkova. "ANTI-INFLAMMATORY THERAPY OF THROAT DISEASES." Folia Otorhinolaryngologiae et Pathologiae Respiratoriae 25, no. 3 (2019): 53–59. http://dx.doi.org/10.33848/foliorl23103825-2019-25-3-53-59.
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Sore throat is one of the most common complaints faced by doctors of various specialties. This symptom accompanies many diseases of the pharynx and larynx, and may be a manifestation of certain diseases that are not associated with the respiratory tract. When choosing therapy, it is necessary by doctors to rationally use the criteria for the appointment of systemic antibiotic therapy. However, local anti-inflammatory therapy as a symptomatic treatment should be selected before accurate confirmation of the etiology of the disease. This provides patients with a quick return to an active life and an improvement in the quality of life in general. The article discusses the etiology and pathogenesis of pain in diseases of the pharynx, modern diagnostic methods and optimal tactics for treating patients. As a symptomatic treatment, to reduce inflammation in the pharynx, the drug Vertum LOR, which belongs to the group of non-steroidal anti-inflammatory drugs of local action, may contain benzidamine as an active substance.
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Gerasimenko, M. Yu, T. N. Zaytseva, and I. S. Evstigneeva. "Physiotherapy of the ear, nose and throat diseases." Fizioterapevt (Physiotherapist), no. 6 (November 20, 2020): 66–79. http://dx.doi.org/10.33920/med-14-2012-08.
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The article provides a review of the literature, allowing to give a historical basis for the emergence of modern approaches to the physiotherapeutic treatment of ENT diseases. Several main highly effective directions of non-pharmacological action in ENT pathology are presented. Issues of physiotherapeutic treatment, which are focused on correcting complications of the disease or adverse reactions, are discussed. The indications are given for various methods of physiotherapeutic treatment in the pathology of the ENT organs.
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&NA;. "DELAYED TREATMENT FOR STREP THROAT." Pediatric Infectious Disease Journal 6, no. 12 (December 1987): 1140. http://dx.doi.org/10.1097/00006454-198706120-00018.
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&NA;. "DELAYED TREATMENT FOR STREP THROAT." Pediatric Infectious Disease Journal 6, no. 12 (December 1987): 1140. http://dx.doi.org/10.1097/00006454-198712000-00018.
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Petrovskaya, M. I. "TREATMENT OF ACUTE INFLAMMATORY DISEASES ACCOMPANIED BY THROAT IRRITATION AND PAIN." Pediatric pharmacology 10, no. 4 (August 14, 2013): 145. http://dx.doi.org/10.15690/pf.v10i4.769.
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Дєєва, Ю. В. "Effective treatment of inflammatory viral diseases of the throat and larynx." Family Medicine, no. 1(69) (January 23, 2017): 100–101. http://dx.doi.org/10.30841/2307-5112.1(69).2017.103210.
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Thirumazhisi Sachithanandam, Sangeetha. "Rising Methicillin-ResistantStaphylococcus aureusInfections in Ear, Nose, and Throat Diseases." Case Reports in Otolaryngology 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/253945.
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The increasing incidence of methicillin-resistantStaphylococcus aureusinfections (MRSA) in ENT diseases is becoming a big clinical concern. Here two patients are described who developed MRSA infections presented with unusual post-FESS epistaxis and postmastoidectomy perichondrial abscess and failed treatment with broad spectrum intravenous antibiotics. Following treatment with oral linezolid combined with local mupirocin dressing both patients fully recovered.
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Osipovsky, V. M. "On the treatment and prevention of angina thymol." Kazan medical journal 29, no. 5-6 (January 12, 2022): 469–70. http://dx.doi.org/10.17816/kazmj89608.
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Chernetska, S. B., and N. M. Beley. "ANALYSIS OF THE PHARMACEUTICAL MARKET OF MEDICINES FOR THE TREATMENT OF THROAT DISEASES." Fitoterapia 1, no. 1 (2019): 34–37. http://dx.doi.org/10.33617/2522-9680-2019-1-34.
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Uraskulovа, B. B., and A. O. Gyusan. "Experience in the use of the drug „Aqua Maris Strong for Throat“ in the complex treatment of inflammatory diseases of the larynx." Russian Otorhinolaryngology 21, no. 3 (2022): 148–54. http://dx.doi.org/10.18692/1810-4800-2022-3-148-154.
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Currently, the treatment of patients with inflammatory diseases of the larynx in most cases is multi-stage, long-term, and requires numerous techniques using specialized equipment. In the daily work of an otorhinolaryngologist with inflammatory diseases of the larynx, drugs are most often used in the form of injections or oral use. Aerosol therapy enables fast and effective therapeutic action with the use of a relatively small dose of the drug and a significant reduction in the negative systemic effect. An effective means of treating diseases of the upper respiratory tract is irrigation and inhalation therapy using sea water, which moisturizes dry mucous membranes, promotes rapid softening and removal of crusts. To establish the therapeutic efficacy of the use of Aqua Maris Strong for Throat in the complex treatment of inflammatory diseases of the larynx, 76 patients suffering from inflammatory diseases of the larynx were selected, who were divided into the main and control groups of the study. Patients of the main group as part of complex therapy for inflammatory diseases of the larynx received inhalation administration of the drug "Aqua Maris Strong for Throat ". The inhalation procedure consisted of 2 inhalations lasting 10 minutes, 2 times a day. The control group of patients – 37 patients received traditional etiotropic treatment of inflammatory diseases of the larynx. As the study showed, in patients who received inhalation administration of the Aqua Maris Strong for Throat preparation as part of the complex therapy of inflammatory diseases of the larynx, positive dynamics of complaints, normalization of the laryngostroboscopic picture were noted faster than in patients of the control group. The advantage of therapy using Aqua Maris Strong for Throat was also confirmed by the restoration of cytopathological changes in local cellular protection, in the form of a decrease in signs of deepithelialization, mucociliary insufficiency, phagocytosis of cellular elements, a decrease in the concentration of pathological flora on the laryngeal mucosa in a shorter period of time than in patients in the control group.
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Hugar, Deepa M., Veerayya Hiremath, Gururaj N, and Shashikala D K. "NASYA IN SHALAKYA TANTRA." International Ayurvedic Medical Journal 9, no. 8 (August 15, 2021): 1874–81. http://dx.doi.org/10.46607/iamj4309082021.
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Shalakyatantra is one of the Ashtanga Ayurveda that deals with the treatment of diseases related to the eye, ear, nose, throat, oral cavity, head, and scalp through oral medications, kriyakalpa, Panchakarma procedures, surgical and para-surgical procedures, etc. Nasya is one among panchakarma; the intranasal method of drug administra- tion meant for treatment and detoxification and is widely used in Shalakyatantra. It is said ‘Nasa hi shiraso dwa- ram’; The nose is the gateway for drug administration for the ailments of head and organs situated in it viz, eye, ear, nose, throat, head, scalp, hair, and oral cavity. Nasya can be used also for the prevention of diseases, to strengthen the indriya (sense organs), and to bring Shiro laghuta by eliminating the doshas. This article is a com- pilation of references to Nasya used in shalakya tantra chikitsa. Keywords: Nasya, Shalakya tantra, Panchakarma, eye, ear, nose, throat, head, scalp, oral cavity.
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Radtsig, E. Yu, and A. V. Gurov. "Sore throat. Crossing problems and finding solutions." Russian Journal of Woman and Child Health 5, no. 3 (2022): 228–36. http://dx.doi.org/10.32364/2618-8430-2022-5-3-228-236.
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The article presents a brief review of the current issues relating to the treatment of acute infectious inflammatory diseases associated with sore throat. Painful throat is one of the most common reasons for the administration of systemic antibacterial drugs as a baseline therapy which, in turn, may facilitate a rise in antibiotic resistance. Recently the focus has shifted to the antibacterial therapy impact on the qualitative and quantitative composition of the microbiota. The review elucidates the opportunities of successful etiotropic therapy amid a low risk of the antibiotic resistance development and a lack of the adverse effects on the oropharyngeal microbiota. Updated information is provided characterizing the pharmacological activity of a bacterium-produced non-ribosomal antimicrobial peptide Gramicidin S and Cetylpyridinium chloride, an antiseptic agent. The highest potency of topical medications can be achieved due to the combined action of multiple synergistic components. A potential combined use of Gramicidin S and Cetylpyridinium chloride is discussed in the review from the standpoint of the risk of antibiotic resistance and the impact on microbiota. The authors conclude that for the treatment of infectious inflammatory diseases of the upper respiratory tract associated with sore throat it is advisable to select biocenosis-saving topical etiotropic therapy. KEYWORDS: Gramicidin S, non-ribosomal antimicrobial peptides, Cetylpyridinium chloride, topical etiotropic therapy, bactericidal activity, antibiotic resistance, microbiocenosis-saving therapy, pharyngitis, tonsillopharyngitis. FOR CITATION: Radtsig E.Yu., Gurov A.V. Sore throat. Crossing problems and finding solutions. Russian Journal of Woman and Child Health. 2022;5(3):228–236 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-228-236.
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Leenders, A. C. A. P., N. R. Renders, M. Pelk, and M. Janssen. "Tonsillectomy for treatment of persistent methicillin-resistant Staphylococcus aureus throat carriage." Journal of Hospital Infection 59, no. 3 (March 2005): 266–67. http://dx.doi.org/10.1016/j.jhin.2004.09.017.
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Zakharova, G. P., S. A. Topchiyan, and K. I. Sapova. "Rationale for the use of NSAIDs with antiseptic action for sore throat in the complex therapy of infectious and inflammatory diseases." Meditsinskiy sovet = Medical Council, no. 20 (November 17, 2022): 111–17. http://dx.doi.org/10.21518/2079-701x-2022-16-20-111-117.
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Sore throat is one of the most common symptoms with which patients seek an appointment with an otorhinolaryngologist, and also serve as the main subjective symptom of infectious and inflammatory diseases of the pharynx. Pain in the throat, making it difficult to swallow, colloquial speech can drastically reduce the quality of life of patients, almost completely turning them off from active personal, work and social life. At the same time, the increase in the intensity of pain in the throat serves as a diagnostic criterion for the growth of the local inflammatory process, leading to its complications (peritonsillitis, paratonsillar abscess, etc.). Given that the main etiopathogenetic factors of the infectious and inflammatory pathology of the throat are viral, bacterial infection and inflammation, antibacterial and anti-inflammatory therapy are the main points of application in the complex treatment of these diseases. The economic and practical inconveniences of the need to purchase a large number of drugs justify the relevance and practical significance of the use of drug release forms, including a combination of etiopathogenetically targeted substances. This article discusses the effectiveness and feasibility of using a combination of NSAIDs and an antiseptic in one preparation. The studied materials allow us to state that the use of both individual components of the drug and its combined composition in the treatment of infectious and inflammatory diseases of the throat is justified, which manifests itself in a fairly quick and complete relief of the symptoms of the disease without complications and side effects of the drug. A comparative evaluation of the effectiveness of mono and complex therapy indicates a significant advantage of complex treatment, which includes two active ingredients of NSAIDs and an antiseptic.
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Kanagaraj, Rajesh, Prabhusaran Nagarajan, Mohamed Marzuk Syed, and Jesudoss Antony. "Analysis of knowledge about acute granular pharyngitis among Tiruchirapalli school children and their parents: connotation for preventing further complications." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 5 (August 27, 2019): 1179. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20193090.
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<p class="abstract"><strong>Background:</strong> Identification and appropriate treatment for the streptococcal pharyngitis decreases the risk of acute rheumatic fever and rheumatic heart disease. By understanding the public perceptions and behaviors related to sore throat is considered as the fundamental for disseminating the health programs to control such diseases. The main objective of this study is to understand the epidemiology and microbiology of acute granular pharyngitis and its treatment in a tertiary care teaching hospital of South India.</p><p class="abstract"><strong>Methods:</strong> This is a prospective and cross-sectional investigation performed by direct interview and written surveys. In this study, school students and their parents were interviewed about the history of sore throats in the last 12 months and treatment received. A focused history and physical examination to detect pharyngitis was conducted and children were referred for follow-up as indicated. </p><p class="abstract"><strong>Results:</strong> A total of 1550 and 1450 students from 13 and 14 schools participated in the study respectively, along with their parents. Three hundred and thirty six (21.6%) parents reported their child had at least one episode of sore throat in the previous year, and 326 (21%) of students reported at least one sore throat in the same time period.</p><p class="abstract"><strong>Conclusions:</strong> Girls were reported to have high level of pharyngitis than boys. Parents have variable knowledge about the frequency of sore throat in their children and its management. These results provide insight into current perceptions and practices related to sore throat and will be used to design public awareness activities aimed at reducing the future risks.</p>
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Yankova, V. G., S. V. Gribanova, I. L. Udyanskaya, V. Yu Grigorieva, and I. D. Parfenov. "A study of dispersion characteristics of sprays for treatment of inflammatory diseases of the throat." Voprosy praktičeskoj pediatrii 13, no. 5 (2018): 7–11. http://dx.doi.org/10.20953/1817-7646-2018-5-7-11.
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Serdyuk, Andriy, Olena Surmasheva, Olena Chernysh, Olena Polka, and Mykhailo Rosada. "STUDY OF THE ANTIMICROBIAL ACTION OF «SANATION +» FOR THE PREVENTION AND TREATMENT OF ACUTE RESPIRATORY DISEASES." JOURNAL OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, no. 1 2022 (July 30, 2022): 355–66. http://dx.doi.org/10.37621/jnamsu-2022-1-4.
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State of the problem. Given the extreme threat of the Covid-19 pandemic in Ukraine to combat it, it is now important to develop and use effective antimicrobials, including disinfectants to disrupt the transmission mechanisms of the pathogen. Promising for use are the means obtained by electrolysis. The aim of the work. The study was to determine the specific activity and safety of «Sanation+», the effectiveness of disinfection of the mucous membranes of the upper respiratory tract of volunteers and evaluate the effectiveness of the tool for the treatment of patients with Сovid-19 and for the prevention of respiratory diseases. Materials and methods. The study used a medical device «Sanation+», which contains hydrochloric acid, highly active oxygen compounds of chlorine, free radicals of chlorine and oxygen, NaCl (mass concentration of active chlorine – 0.035%). The antimicrobial action of the product according to the Order of the Ministry of Health of Ukraine N 2024, dated September 3, 2020. To study the effectiveness of decontamination of the upper respiratory tract of volunteers with the «Sanation+» used devices for the formation of aerosols: – nebulizer «Nano Mist Sprayer» (China), which sprays the drug with a volume of 1.25 - 1.45 cm3 for 60 seconds. The distance from the spray to the mucous membranes was 5 - 10 cm; – compressor inhaler, model CN-123 (Japan). Results. It was found that the tool «Sanation+» showed high virilicidel, bactericidal and yeastic activity under exposure for 30 and 60 sec. for Escherichia coli K12 NCTC 10538 lg R > 5.42, for Pseudomonas aeruginosa lg R > 5.37; for Staphylococcus aureus lg R > 5.34; for Candida albicans lg R > 4.31. Remediation + when used undiluted and exposed for 30 sec is an effective tool for disinfection from macro- and microviruses, as evidenced by the high logarithms of the reduction of bacteriophages: T2 – > 5.08 lg, MS2 – > 5.12 lg, indicating the virucidal action of the tool against enveloped and non-enveloped viruses. As a result of the application of «Sanation+» through the nebulizer «Nano Mist Sprayer» there was a significant reduction in the number of microorganisms on the mucosal surface of nasal volunteers: after 5 min the drug decreased by 4.22 lg, on the throat mucosa – by 4.14 lg. The use of the drug through an inhaler helped to reduce the number of microorganisms on the surface of the mucous membranes of both the nose and throat. The most effective duration of action is 5 min (reduction factor: for the nasal mucosa RF = 4.23, for the throat mucosa RF = 4.78). Conclusions. High efficiency of means for rehabilitation of respiratory tracts «Sanation+», for application in complex therapy at treatment of a coronavirus disease at 55 patients is established. The use of «Sanation+» for the prevention of Covid-19 among health care workers in medical institutions of the disease was not detected. Key words: remedy «Sanation+», bactericidal, virucidal, volunteers, patients, Сovid-19.
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Upadhyay, Animesh A., and Poorva P. Bhide. "Vitamin D and calcium deficiency in otolaryngological diseases." International Journal of Otorhinolaryngology and Head and Neck Surgery 2, no. 4 (September 26, 2016): 216. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20163468.
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<p class="abstract"><strong>Background:</strong> A prospective study to observe the prevalence of deficiency of vitamin D and calcium in out patients of otolaryngology clinic at R.C.S.M Government medical college, Kolhapur, India. The patients attending outpatient of otolaryngology clinic with various complaints and not responding to conventional treatment were advised for assessment of vitamin D [25 (OH)D] level in blood.</p><p class="abstract"><strong>Methods:</strong> The age, sex, occupation, chief complaints, obesity and provisional diagnosis was noted in all cases. A total of 86 patients were examined, maximum patients were in the age group of 7-15 years. The chief complaints in majority of the patients were sore throat with recurrent upper respiratory tract infection. </p><p class="abstract"><strong>Results:</strong> Only three patient’s vitamin D levels were found to be within normal limits. In rest 83 (96.51%) it was either deficient 57 (66.28%) or insufficient 21 (24.42%).</p><strong>Conclusions:</strong> The incidence of vitamin D deficiency is extremely common in ear, nose and throat disease (ENT) patients. The results of vitamin supplementation were promising in cases of pharyngitis, upper respiratory tract infection (URTI) with asthma, post operation of chronic suppurative otitis media, empirical supplementation of vitamin D in all ENT patients not responding to conventional treatment is worth trying.
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Ryazantsev, S. V., and S. V. Pavlova. "Modern possibilities of topical therapy of upper respiratory tract and throat infectious inflammatory diseases." Meditsinskiy sovet = Medical Council, no. 6 (May 27, 2020): 14–20. http://dx.doi.org/10.21518/2079-701x-2020-6-14-20.
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Introduction. At the present moment, the healthcare system has faced significant problems in terms of infectious safety: an unprecedented increase in the spectrum of pathogenic microorganisms, the annual appearance of 1-2 “new” infectious diseases, an increase in the proportion of emergent infections, especially of viral etiology, against which there are no effective drugs, and the spread drug-resistant microorganisms, as well as the establishment of a direct etiological or trigger role of microbial agents in the development of somatic human pathology.The aim of our work was to evaluate the topical preparation (amylmetacresol and dichlorobenzyl alcohol) used to stop the inflammatory process and eliminate pain in patients with pharyngeal diseases.Patients and methods. We studied the antimicrobial, antiviral and anti-inflammatory effect of a fixed combination of 2,4-dichlorobenzyl alcohol 1.2 mg, amylmethacresol 0.6 mg. 20 patients with manifestations of inflammatory changes in the pharyngeal cavity underwent treatment with Strepsils resorption tablets according to the scheme. The control group consisted of 10 patients who received therapy according to the usual scheme.Results and discussion. As a result of the therapy, sore throat in patients in the first group completely disappeared amongst 15 patients, and its intensity significantly decreased amongst 5 patients. Patients noted that the use of Strepsils resorption tablets reduces the sensation of a foreign body, irritation in the pharynx and oral cavity; eliminates pain, tickle, feeling of soreness in the throat. The analgesic effect of the drug manifested itself after about 5 minutes and lasted up to 2 hours. By the end of the treatment, all patients from this group had unpleasant sensations and discomfort completely stopped.Conclusion. Amylmethacresol/Dichlorobenzyl Absorption Tablets is a well-tolerated and effective over-the-counter treatment offering functional, sensory and emotional benefits for patients with acute sore throat, providing a quick onset of effect and may be more relevant and suitable than antibiotics when pharyngitis associated with viral infections of the upper respiratory tract.
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Orishchak, Diana, Nataliia Vasyliuk, and Ostap Orishchak. "Lump in the Throat – an Algorithm for the Actions of a Physician." Galician Medical Journal 27, no. 2 (June 30, 2020): E2020211. http://dx.doi.org/10.21802/gmj.2020.2.11.
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Diagnosis and treatment of patients with complaints of the “lump in the throat” remain a complex multidisciplinary problem. This is due to the polyetiology of factors causing similar symptoms and an empirical approach to the treatment. “Lump in the throat” is one of the clinical manifestations of upper respiratory tract paresthesia. According to the literature data, there is the reason for referral to an otolaryngologist in 4.1 to 5.0% of cases.
The objective of the research was to optimize and improve the diagnosis and pathogenetic approach to the “lump in the throat” treatment.
Materials and Methods. To achieve the specified objective, a comprehensive examination of 38 patients who sought an otolaryngologist’s medical advice, complaining of a “lump in the throat” at the age of 18-45 years (26 women and 12 men), was performed. For the purpose of optimal diagnostics, general clinical examination, examination of ENT organs, endoscopic examination of the nasal cavity and nasopharynx, microlaryngoscopy were performed; the condition of patients’ psycho-emotional status was assessed (consultation of psychologist and psychiatrist).
Results. A comprehensive clinical study of 38 patients with complaints of the “lump in the throat” at the age of 18-45 years was performed. Psychosomatic disorders were detected in 26 patients; ENT organ diseases were present in 12 patients. All patients received treatment depending on the diagnosed somatic, otorhinolaryngological and psychosomatic pathology.
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Bezshapochny, Sergey, and Irina Hychak. "Optimal therapy of inflammatory diseases in the risk groups." OTORHINOLARYNGOLOGY 2-3(2) 2019, no. 2-3(2) 2019 (November 29, 2019): 58–62. http://dx.doi.org/10.37219/2528-8253-2019-2-58.
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Topicality: Pregnant women are at increased risk of susceptibility to inflammatory diseases of the pharynx. Unfortunately, there are currently no approved protocols for the treatment of ENT diseases for such patients in Ukraine. It is very important to choose a safe and effective drug with minimal absorption in to the general blood flow. Another important point for the doctors the legal aspect, namely, the absence of contraindications to the appointment of pregnant women in the instructions for use of the medicine. These criteria are met by Celista spray for a throat, which is based on the active substance miramistin (0.1 mg/ml). Materials and methods: We conducted a study that involved 30 pregnant women. These lection criteria were pregnant women from I to III trimester with a diagnosis of acute pharyngitis / tonsillitis / tonsillopharyngitis, up to 5 days after the disease, 0-3 points on a modified McAizek-Center scale, voluntary consent and adequate attitude to the study. All patients were prescribed topical irrigation of Celista spray x 4 times a day. The examination complex included subjective assessment of the condition on a 10-point visual-analogue scale, symptom severity assessment was performed using a questionnaire on a 4-point scale by criteria such as sore throat, burning, coughing (0 – no symptom, 1 – the symptom is poorly expressed, 2 – the symptom is moderately expressed, 3 – the symptom is strongly expressed). Objective examination included assessment of the condition by criteria such as hyperemia of the posterior pharyngeal wall; hypertrophy of the follicles of the posterior wall of the pharynx; hypertrophy and swelling of the tonsils; regional lymphadenitis for 0; 3; 5; 7 days. Results: It was found that the pain index decreased by 1.6 points, laceration in the throat – by 1.78 points, cough – by 0.3 points after treatment. A similar tendency was observed in the objective status: hyperemia of the posterior pharyngeal wall decreased by 1.5 points, hypertrophy of the pharynx follicles – by 1.27 points, hyperemia and swelling of the tonsils – by 0.8 points, regional lymphadenitis – by 0.5 points. Conclusion: Thus, given that the absorption of Celista spray is actually absent, the drug has no contraindications for prescription during pregnancy, and based on our results, we can confirm the effectiveness of its use during pregnancy for the local treatment of acute inflammatory diseases of the pharynx in pregnant women in any period.
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Ryazantsev, Sergey V., Svetlana S. Pavlova, Sergey A. Eremin, and Valery D. Gorpinich. "Antiseptics as an alternative to systemic antibiotic therapy." Consilium Medicum 23, no. 3 (2021): 256–60. http://dx.doi.org/10.26442/20751753.2021.3.200774.
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Sore throat is one of the most frequent reasons for going to the doctor and prescribing irrational antibacterial therapy. The reasons for this are many – from the difficulties of etiological diagnosis and the development of relapses and possible severe complications to the personal attitude of doctors and patients to the choice of treatment. At the same time, the issue of antibiotic resistance, side effects associated with the appointment of antibacterial therapy, is one of the most important problems of modern health care around the world. Difficulties in the process of clinical observation of patients, the peculiarities of the course of infectious and inflammatory diseases of the pharynx are factors requiring constant improvement of methods of providing medical care. Antiseptics play a significant role in the treatment of sore throat, exceeding the frequency of use of antibiotics. So, one of the antiseptics used topically, the effectiveness of which has been proven in clinical studies, is Strepsils, which includes 2,4-dichlorobenzyl alcohol and amylmetacresol. The results of clinical studies of the drug indicate its positive effect in patients with sore throat. All this things allow us to recommend that this complex antiseptic be more often included in the treatment of infectious and inflammatory diseases of the oral cavity and pharynx.
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Drozdova, M. V., Yu S. Preobrazhenskaya, S. V. Ryazantsev, and S. S. Pavlova. "Inflammatory diseases of the pharynx in children." Meditsinskiy sovet = Medical Council, no. 1 (February 26, 2022): 51–57. http://dx.doi.org/10.21518/2079-701x-2022-16-1-51-57.
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Introduction. Inflammatory diseases of the lymphoid ring of the pharynx in children are widespread and account for more than 30% in the structure of ENT pathology. Lymphoid tissue, especially the palatine tonsils, largely determines the formation of local and general protective reactions of the child’s body.The aim of this work is to assess the efficacy and safety of using topical bacterial lysate in chronic tonsillitis of streptococcal and herpes viral etiology in frequently ill children.Materials and methods. The study was conducted on a sample of 31 children aged 7–17 who were treated in the pediatric department of the Saint Petersburg Research Institute of Ear, Throat, Nose and Speech inpatiently or outpatiently, which were divided into 2 groups. Group 1 consisted of 15 children with decompensated chronic tonsillitis of streptococcal etiology, who were prescribed tonsillectomy according to indications. Group 2 consisted of 16 children with chronic compensated tonsillitis, who, after an acute respiratory infection, showed signs of acute pharyngitis in the form of pain and discomfort in the throat, perspiration, low-grade body temperature. In both groups children were prescribed to take topical baclerial lysates.Results. A subjective pain relief of sore throat in patients (groups 1 and 2) was observed from day 2–3 of administration of the topical bacterial lysate. The clinical therapeutic effect resulted in decreased intensity of inflammation of the posterior pharyngeal wall, reduction in size and tenderness of regional lymph nodes from day 4–5 of administration of the drug. The clinical recovery from acute pharyngitis in children of both groups was observed in 98% of cases at visit 3.Conclusion. The persistence of pathogenic viruses and bacteria contributes to the development of secondary immunodeficiency states and participates in the formation of a kind of “vicious circle” In these causes prescription of topical baclerial lysates may be an effective conservation therapy as well as antibiotics and antiviral drugs. The drug showed its efficacy in the treatment of acute and chronic diseases of the pharynx in children of both viral and bacterial etiology.
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Derbeneva, M. L., and A. L. Guseva. "Acute respiratory viral diseases: modern approaches to the diagnosis and treatment." Medical Council, no. 20 (November 16, 2019): 32–37. http://dx.doi.org/10.21518/2079-701x-2019-20-32-37.
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Acute respiratory viral infections (ARVI) are one of the most common reasons patients seek ambulatory care. ARVIs can be caused by more than 200 strains of viruses, among which rhinoviruses remain a leading cause. The article discusses the epidemiological characteristics of ARVI and the economic damage caused by high incidence to the community. The clinical presentation of ARVI is nearly always accompanied by a combination of symptoms such as nasal discharge, nasal congestion, sore throat and cough combined with muscle pain, weakness, fatigue, headache and decreased appetite. Diagnosis of acute respiratory viral infections must be differentiated from influenza, allergic rhinitis, streptococcal tonsillitis, sinusitis and otitis media. Practicing hand hygiene is an effective way to prevent infections. The article discusses possibilities and effectiveness of concomitant adjuvant therapy, including the use of decongestants, topical glucocorticosteroids, nasal irrigation solutions, non-steroidal anti-inflammatory drugs, paracetamol and antitussive drugs. Antibacterial therapy does not have a positive effect on the course of ARVI. A clinical case describing the management of a patient with ARVI is provided.
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Jönsson, Maria, Yvonne Qvarnström, Lars Engstrand, and Göte Swedberg. "Clarithromycin treatment selects for persistent macrolide-resistant bacteria in throat commensal flora." International Journal of Antimicrobial Agents 25, no. 1 (January 2005): 68–74. http://dx.doi.org/10.1016/j.ijantimicag.2004.08.011.
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Bradley, Patrick J. "A study of a provincial ear, nose and throat service in a British city prior to the National Health Service: Nottingham and South Nottinghamshire (1886–1947)." Journal of Laryngology & Otology 135, S1 (July 9, 2021): S1—S12. http://dx.doi.org/10.1017/s0022215121000943.
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AbstractBackgroundIt was in twentieth-century Britain that the two distinct surgical disciplines, otology and laryngology, became united under the title oto-laryngology. Aural departments were established in general hospitals in the hands of specialists long before throat departments. The development and politics of the specialty occurred in London, while provincial services commenced in the early eighteenth century, with ophthalmologists, setting up a clinic or dispensary, progressing onto a hospital.MethodsThe following resources were used: the Nottinghamshire Archives; Manuscripts and Special Collections at the University of Nottingham Libraries and The Local Studies Library, Nottingham Central Library.ResultsThe Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose was established in 1886, staffed by part-time general practitioners. The Nottingham Children's Hospital appointed two qualified surgeons in the 1910s and subsequently the General Nottingham Hospital appointed them as honorary assistant surgeons. Both hospitals provided access to beds, not available to the Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose. Following The Education Act of 1907, Nottingham created a School Health Services. By the 1920s, Nottingham had four institutions providing clinical and surgical ENT services. The National Hospitals Survey conducted in 1945 recommended that the Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose be closed and amalgamated with The General Hospital Nottingham.ConclusionThe General Hospital Nottingham was slow to create a service for the diagnosis and treatment of ENT diseases and disorders, but established a Departmental Service by 1927. The surgical staffing was common to all four of the ENT services from mid-1930.
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Tack, Kenneth J., Daniel C. Henry, W. Manford Gooch, Douglas N. Brink, Constance H. Keyserling, and The Cefdinir Pharyngitis Study Group. "Five-Day Cefdinir Treatment for Streptococcal Pharyngitis." Antimicrobial Agents and Chemotherapy 42, no. 5 (May 1, 1998): 1073–75. http://dx.doi.org/10.1128/aac.42.5.1073.
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ABSTRACT A multicenter, randomized, controlled, investigator-blind study was performed to evaluate the safety and efficacy of oral cefdinir versus oral penicillin V for the treatment of pharyngitis due to group A beta-hemolytic streptococci (GABHS). Patients 13 years of age and older were randomized to receive either oral cefdinir (300 mg twice a day) for 5 days followed by placebo for 5 days or oral penicillin V (250 mg four times a day) for 10 days. Throat cultures were obtained, and signs and symptoms of pharyngitis were recorded at study admission and follow-up visits on study days 11 to 15, 16 to 20, and 25 to 31. Patients kept a diary to record medication intake and their assessment of throat pain at admission and at each day of study treatment. Five hundred fifty-eight patients were enrolled, of whom 432 (77.4%) were clinically and microbiologically evaluable. The GABHS eradication rates 5 to 10 days after completion of therapy were 193 of 218 (88.5%) in the cefdinir group and 176 of 214 (82.2%) in the penicillin group (P = 0.053). Clinical cure rates were 89.0 and 84.6%, respectively (P = 0.80). By the time of the long-term follow-up visit, 2 to 3 weeks after completion of treatment, 156 of 191 (81.7%) of the assessable cefdinir patients and 152 of 195 (77.9%) of the penicillin patients remained free of GABHS. Both treatments were well tolerated, with adverse reaction rates of 18.3% in the cefdinir study arm and 15.0% in the penicillin study arm (P = 0.278). Five-day treatment with cefdinir is safe and effective therapy for GABHS pharyngitis. Based on its twice-a-day dosage and shorter course of therapy, leading to potentially greater patient compliance, cefdinir may be considered for use in the treatment of pharyngitis caused by GABHS.
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Lu, Jihong, Jing Li, Yiping Ren, Doug Stevenson, and Mark Bartlett. "An Open Label, Self-Controlled Study to Evaluate a “Fresh Clear” Formulation on Throat Symptoms in a Smoking Population." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 431. http://dx.doi.org/10.1093/cdn/nzaa045_064.
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Abstract Objectives Smoking has been associated with several respiratory problems including cough, phlegm production, dry throat, itchy throat, and hoarse voice. The objective of this study was to evaluate the effect of a botanical extract-based blend, Fresh Clear (FC), on the respiratory system of a smoking population. FC consists of 3 of botanical extracts: broccoli seed (Brasssica oleracea), Luo Han Guo (Siraitia grovenorii), and Honeysuckle Flower Bud (Lonicera japonica). Broccoli seed is rich in Sulforaphane, which was reported to promote healthy inflammatory balance, as well as to positively impact oxidative stress and DNA-damaging substances. Both Luo-han-guo and Honeysuckle Flower Bud have been used as traditional Chinese medicines for the treatment of pharyngitis, pharyngeal pain, as well as an antitussive remedy and anti-inflammatory and anti-oxidative agent in China and East Asia. Methods This is an open-label, self-controlled study. Eighty smoking volunteers who had mild or moderate throat discomfort without respiratory diseases and other severe diseases were recruited. Volunteers were asked to consume FC at a dose of 1.45 g, 2 times/day for 8 weeks. Their symptoms of cough, phlegm production, dry throat, itchy throat, and hoarse voice were evaluated at week 0 (Baseline), week 4, and week 8 by questionnaire. Ultimately, 75 volunteers completed the study, 44 males and 31 females. Average age was 47.0 ± 10.6 years. All volunteers had smoked for over 3 years. Results We found significant amelioration of the listed throat symptoms as compared to baseline after 4- and 8- weeks FC consumption. Effective ratios at week 4 and week 8 respectively were 88% and 94% in cough, 91% and 95% in phlegm production, 90% and 90% in dry throat, 92% and 95% in itchy throat, and 94% and 89% in hoarse voice. Conclusions 8 weeks consumption of FC was shown to ameliorate smoking-induced throat symptoms in a smoking population with a smoking history of over 3 years. Funding Sources Nu Skin Enterprises.
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Khan, Afsha, Catherine A. Lawson, Mark A. Quinn, Amanda H. Isdale, and Michael J. Green. "Successful Treatment of ANCA-Negative Wegener's Granulomatosis with Rituximab." International Journal of Rheumatology 2010 (2010): 1–2. http://dx.doi.org/10.1155/2010/846063.
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Wegener's Granulomatosis (WG) is a systemic vasculitis typically associated with antineutrophil cytoplasmic antibodies (ANCAs). A small proportion of patients are ANCA negative, however, and this is more commonly found in individuals with disease limited to the ears, nose, throat, and lungs, who do not have renal involvement. Rituximab is a monoclonal anti-CD20 antibody that has been demonstrated to be effective in the treatment of autoantibody-associated rheumatic diseases, including systemic WG. We report the case of a patient with ANCA-negative WG who responded well to rituximab, illustrating that even in the absence of detectable autoantibodies, B-cell depletion can be effective.
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Munjal, Manish, Anurag Chowdhary, Harsimran Bhatti, Porshia Rishi, Nitika Tuli, Shubham Munjal, and Avantika Garg. "Clinicoepidemiological profile of ear, nose, throat patients in outpatient clinic of tertiary health care facility in Punjab." International Journal Of Community Medicine And Public Health 7, no. 11 (October 26, 2020): 4522. http://dx.doi.org/10.18203/2394-6040.ijcmph20204755.
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Background: This study evaluated the profile of ailments in patients presenting to outpatient clinic of tertiary care hospital of North India that caters to ENT diseases in population of Punjab, Haryana, Himachal Pradesh and Jammu and Kashmir.Methods: A retrospective study was undertaken by analysing the medical records of patients managed at the department of otorhinolaryngology and head and neck surgery at the tertiary care hospital, Punjab from Jan 2018 to Dec 2018 and all essential data was collected.Results: Total no. of patients presenting to the ENT OPD during the period of assesment were 32,475. 49.30% were males and 50.70 % were females, respectively. 29.70% were children below 15 years. The number of patients presenting per month were 2706, with maximum no. of patients presenting in the month of August to November. Patients with ear diseases were 9280 (28.57%), Nose diseases were 11963 (36.83%), and throat diseases were 11232 (34.58%).Conclusions: This study showed that awareness of ENT ailments and visits for specialised treatment is on the rise rather than primary level treatment at local or general medicine or family physician level.
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Guseva, A. L., and M. L. Derbeneva. "Differential diagnosis and effective therapy for sore throat." Meditsinskiy sovet = Medical Council, no. 18 (December 1, 2021): 166–71. http://dx.doi.org/10.21518/2079-701x-2021-18-166-171.
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Sore throat is a common complaint, which can be caused by a typical viral pharyngitis, or it can be rooted in a life-threatening disease such as epiglottitis or inflammation of the cellular spaces in the throat and neck. The doctor should take a closer look at a patient with a sore throat, immediately make a differential diagnosis and prescribe adequate treatment, including surgical intervention, if necessary.The article discusses the most common causes of a sore throat, including various types of pharyngitis, paratonsillar abscess, parapharyngeal abscess, retropharyngeal abscess, epiglottitis.Viral pharyngitis has a favourable prognosis, resolves without intervention and complications, but bacterial and fungal pharyngitis have a more severe course. Streptococcal pharyngitis caused by group A в-hemolytic streptococcus holds a dominant position in bacterial etiology and requires the use of antibiotic therapy. The differential diagnosis of streptococcal pharyngitis is based on the modified Centor scores in the routine clinical practice. Antibiotic therapy for streptococcal pharyngitis includes a 10-day course of unprotected penicillins. If a patient has an allergic reaction to penicillins, it is recommended to use clindamycin or clarithromycin. The surgical intervention combined with intramuscular or intravenous antibiotic therapy is recommended for the treatment of purulent processes in the cellular spaces of the neck. These diseases can have life-threatening complications, which include neurological damage, the spread of purulent process in the mediastinum with the development of mediastinitis, laryn-geal stenosis, sepsis, necrotizing fasciitis, jugular vein thrombosis and erosion of the carotid artery. The third generation cephalosporins and protected penicillins are recommended for the treatment of epiglottitis, and respiratory fluoroquinolones are used, if a patient has a history of allergic reactions to penicillins. In severe cases with symptoms of stenosis, intubation can be performed in addition to the use of antibiotics.
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Lennon, Diana, Melissa Kerdemelidis, and Bruce Arroll. "Meta-Analysis of Trials of Streptococcal Throat Treatment Programs to Prevent Rheumatic Fever." Pediatric Infectious Disease Journal 28, no. 7 (July 2009): e259-e264. http://dx.doi.org/10.1097/inf.0b013e3181a8e12a.
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Mollema, F. P. N., J. A. Severin, J. L. Nouwen, A. Ott, H. A. Verbrugh, and M. C. Vos. "Successful Treatment for Carriage of Methicillin-Resistant Staphylococcusaureus and Importance of Follow-Up." Antimicrobial Agents and Chemotherapy 54, no. 9 (June 14, 2010): 4020–25. http://dx.doi.org/10.1128/aac.01240-09.
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ABSTRACT With this prospective observational follow-up study of 165 methicillin-resistant Staphylococcus aureus (MRSA)-positive individuals (23 health care workers and 142 patients), we determined that our MRSA eradication therapy protocol results in a high success rate (81%). Five or more negative culture sets give a predictive value for MRSA eradication therapy success of >90%. Furthermore, MRSA colonization, at least in the throat, and the presence of wounds just before the start of MRSA eradication therapy are associated with MRSA eradication therapy failure.
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Segador, J., V. F. Gil-Guillen, D. Orozco, F. Quirce, M. C. Carratalá, A. Fernández-Parker, and J. Merino. "The effect of written information on adherence to antibiotic treatment in acute sore throat." International Journal of Antimicrobial Agents 26, no. 1 (July 2005): 56–61. http://dx.doi.org/10.1016/j.ijantimicag.2005.03.009.
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A, Khanifar. "The Effect of Ezetimibe in the Treatment of Ebola." Virology & Immunology Journal 5, no. 3 (August 2, 2021): 1–7. http://dx.doi.org/10.23880/vij-16000281.
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Background: In this article, we are looking for treatment for Ebola virus. We will do it using a cholesterol-lowering drug called Ezetimibe. Methods: Marburg and Ebola hemorrhagic fevers are severe, systemic viral diseases affecting humans and non-human primates. They are characterized by multiple symptoms such as hemorrhages, fever, headache, muscle and abdominal pain, chills, sore throat, nausea, vomiting and diarrhea. Elevated liver-associated enzyme levels and coagulopathy are also associated with these diseases. Marburg and Ebola hemorrhagic fevers are caused by (Lake Victoria) Marburg virus and different species of Ebola viruses, respectively. They are enveloped, single-stranded RNA viruses and belong to the family of filoviridae. Case fatality rates of filovirus disease outbreaks are among the highest reported for any human pathogen, ranging from 25 to 90% or more. But when Ezetimibe is given to patients with the Ebola virus, we see that the drug blocks the transmission of the virus to the body by delivering the virus to the immune system. Results: In this article are paid to effect of drug Ezetimibe in the treatment of disease Ebola.NPC1L1 carry Ebola virus that by Ezetimibe, NPC1L1 disabled and cannot carry the virus with you. In fact, this drug (Ezetimibe) is a supplier of antigen to antibodies. We will also look at the function of the NPC1L1 and NPC1 receptors and the drug Ezetimibe. Conclusions: Ezetimibe has a higher affinity for NPC1L1 receptor than cholesterol, and cholesterol has a higher affinity for NPC1L1 receptor than Ebola virus. In fact, if we want to show the percentage of desire for NPC1L1 receptor, it is as follows: Ezetimibe> Cholesterol> Ebola virus
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Putra, Dede Wira Trise, Ade Oka Utami, Minarni, and Ganda Yoga Swara. "Accuracy Level of Diagnosis of ENT Diseases in Expert System." Jurnal KomtekInfo 6, no. 2 (November 19, 2019): 127–34. http://dx.doi.org/10.35134/komtekinfo.v6i2.51.
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Purpose of this study is to test the accuracy of ear, nose and throat (ENT) diseases with an expert system. The expert system is designed to help people make early detection of illnesses so that the possibility of delay in treatment can be minimized. The method used is Naive Bayes with Forward Chaining Inference for 14 types of diseases with 42 symptoms originating from ENT specialists. The method was tested on 25 patients who used an expert system and adjusted the results of expert diagnoses. The test results are influenced by the number of symptoms, so that the accuracy obtained is only 88%. So this research is needed to be further developed to find a more reliable expert system in diagnosing ENT diseases.
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&NA;. "ANTIBIOTIC TREATMENT OF ADULTS WITH SORE THROAT BY COMMUNITY PRIMARY CARE PHYSICIANS: A NATIONAL SURVEY, 1989???1999." Infectious Diseases in Clinical Practice 10, no. 9 (December 2001): 496–97. http://dx.doi.org/10.1097/00019048-200112000-00010.
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Matilda Uju Ibekwe and Edirirn Nosa Oghenekaro. "Clinicopathologic profile of sinonasal diseases in a tertiary hospital in Port Harcourt." World Journal of Advanced Research and Reviews 10, no. 1 (April 30, 2021): 012–18. http://dx.doi.org/10.30574/wjarr.2021.10.1.0126.
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Background: In a typical ear nose and throat clinic, disease conditions involving the nose and paranasal sinuses are not uncommon. The aim of this study is to determine the clinicopathologic profile of these diseases as it occurs in university of Port Harcourt teaching hospital. Methodology: A retrospective descriptive analysis of all patients with diagnosis of sinonasal disease that presented in the ear nose and throat surgery department of university of Port Harcourt teaching hospital within the period of 5years (from 2016 – 2020). Data retrieved were biodata, clinical features, diagnosis and treatment, these were all collated and analysed. Patients without complete records were excluded. The patients recruited had clinical diagnosis which was aided by radiological investigations and confirmed by histology. Result: A total of 68 patients were studied within the 5year period. There were 35males and 33 females. The mean age was 33.96+/_17.9 years. The age groups 11-20 and 41-50 were more affected. Rhinosinusitis was the commonest condition seen while inflammatory polyp was the commonest histologic diagnosis. Polypectomy with bilateral antrostomy was the commonly done surgery in 26.4% age. Conclusion: Disease of the nose and paranasal sinuses are commonly seen in ENT practice and rhinosinusitis is the commonest entity encountered with inflammatory polyp as the commonest histopathologic finding. Squamous cell carcinoma was the commonest malignant lesion seen occurring more in males. Age distribution of the diseases was statistically significant.
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Iacovou, Emily, Petros V. Vlastarakos, George Papacharalampous, George Kampessis, and Thomas P. Nikolopoulos. "Diagnosis and treatment of HIV-associated manifestations in otolaryngology." Infectious Disease Reports 4, no. 1 (January 2, 2012): 9. http://dx.doi.org/10.4081/idr.2012.e9.
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Almost 30 years after its first description, HIV still remains a global pandemic. The present paper aims to review the current knowledge on the ear, nose and throat (ENT) manifestations of HIV infection, and present the available diagnostic and treatment options. A literature review was conducted in Medline and other available database sources. Information from related books was also included in the data analysis. It is well acknowledged that up to 80% of HIV-infected patients eventually develop ENT manifestations; among which, oral disease appears to be the most common. Oro-pharyngeal manifestations include candidiasis, periodontal and gingival disease, HSV and HPV infection, oral hairy leucoplakia, Kaposi’s sarcoma, and non- Hodgkin’s lymphoma. ENT manifestations in the neck can present as cervical lymphadenopathy or parotid gland enlargement. Respective nasal manifestations include sinusitis (often due to atypical bacteria), and allergic rhinitis. Finally, otological manifestations include otitis (externa, or media), inner ear involvement (sensorineural hearing loss, disequilibrium), and facial nerve palsy (up to 100 times more frequently compared to the general population). Although ENT symptoms are not diagnostic of the disease, they might be suggestive of HIV infection, or related to its progression and the respective treatment failure. ENT doctors should be aware of the ENT manifestations associated with HIV disease, and the respective diagnosis and treatment. A multi-disciplinary approach may be required to provide the appropriate level of care to HIV patients.
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Vaks, Vladimir, Vladimir Anfertev, Andrey Ayzenshtadt, Maria Chernyaeva, Elena Domracheva, Kseniya Glushkova, Roman Larin, and Maria Shakhova. "Novel Approaches in the Diagnostics of Ear-Nose-Throat Diseases Using High-Resolution THz Spectroscopy." Applied Sciences 13, no. 3 (January 26, 2023): 1573. http://dx.doi.org/10.3390/app13031573.
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Nowadays, physicochemical methods of analysis are used in medical diagnostics. One can identify metabolites characteristic of a particular disease. The compilation of a metabolic profile will facilitate the diagnosis of diseases, evaluate their stage and etiology, and predict treatment. The goal of the study is to analyze the metabolite composition of the ear-nose-throat (ENT) tissues by high-resolution THz spectroscopy based on nonstationary effects and compare metabolites formed during the thermal decomposition of relatively healthy mucosa, polyps, and cysts. Studies were performed with the spectrometers operating from 118 to 178 GHz. The chemical compounds were identified using online catalogs. In all samples, there are such substances as methanol, propanediol, acetaldehyde, acetonitrile, butyronitrile, methyl mercaptan, azole, ethylene sulfide, carbon sulfide, and sulfur dioxide. In the spectrum of relatively healthy mucosa, the number of absorption lines of these substances is much less than in the spectrum of the polyps and cysts, which indicates their lower concentration. In the products of the polyps and cysts, acetone, hydroxyacetone, dihydroxyacetone, propionitrile, acrylonitrile, aminopropionitrile, hydroxyacetonitrile, aminoacetonitrile, methylbutironitrile, propanal, glycolaldehyde, lactaldehyde, and malone dialdehyde appear. The products of cysts’ thermal decomposition also contain acetic and acrylic acids. High-resolution THz spectroscopy has been shown to be promising for detecting disease metabolites in ENT tissues.
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Gwaltney, Jack M., Birgit Winther, James T. Patrie, and J. Owen Hendley. "Combined Antiviral-Antimediator Treatment for the Common Cold." Journal of Infectious Diseases 186, no. 2 (July 2002): 147–54. http://dx.doi.org/10.1086/341455.
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Abstract A randomized, controlled, double-masked clinical trial was conducted with a combination antiviral-antimediator treatment for experimental rhinovirus colds. In all, 150 healthy men and women (aged 18–51 years) were randomly assigned to 1 of 3 groups: intranasal interferon (IFN)–α2b (6×106 U every 12 h × 3) plus oral chlorpheniramine (12 mg extended release) and ibuprofen (400 mg) every 12 h for 4.5 days (n=59 subjects); intranasal placebo plus oral chlorpheniramine and ibuprofen (n=61 subjects); or intranasal and oral placebos (n=30 subjects). Treatment was started 24 h after intranasal viral challenge. During the 4.5 days of treatment with IFN-α2b, chlorpheniramine, and ibuprofen, the daily mean total symptom score was reduced by 33%–73%, compared with placebo. Treatment reduced the severity of rhinorrhea, sneezing, nasal obstruction, sore throat, cough, and headache and reduced nasal mucus production, nasal tissue use, and virus concentrations in nasal secretions. IFN-α2b added to the effectiveness of chlorpheniramine and ibuprofen and was well tolerated
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Tümay, Hür Can, and Ayhan Filazi. "Veteriner Hekimlikte Kulak, Burun, Boğaz Alanında Kullanılan Antiseptikler." Turkish Journal of Agriculture - Food Science and Technology 8, no. 5 (May 29, 2020): 1083–89. http://dx.doi.org/10.24925/turjaf.v8i5.1083-1089.3279.
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Although the studies on ear, nose and throat (ENT) diseases and treatment methods are high in human medicine, they are rarely performed and neglected in veterinary medicine. Antibiotics are generally preferred for ENT diseases in animals. However, there is an increase in infections from microorganisms that develop multiple antibiotic resistance due to overuse and misuse of antibiotics. Another group of drugs used in ENT diseases are antiseptics. Bacterial resistance to agents used as antiseptics is more limited than antibiotics. Studies on the use of substances with antiseptic properties in the treatment of ENT disorders in animals have been limited. Even though these substances are used empirically in the field, there are no studies in the literature examining the effects of these substances on ENT. In this review, the properties of antiseptic substances recommended for use in the field and in the literature for ENT diseases of animals are discussed.
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Lee, Yi-Chieh, Hsueh-Yu Li, and Wan-Ni Lin. "Isolated Epiglottic Manifestations of HIV Infection: Two Cases Reports." Microorganisms 10, no. 12 (December 5, 2022): 2404. http://dx.doi.org/10.3390/microorganisms10122404.
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Diagnosis of the Human Immunodeficiency Virus (HIV) remains challenging due to non-specific clinical presentations and mostly flu-like symptoms, e.g., fever, headache, sore throat, and general weakness. Oral lesions, such as oral candidiasis and Kaposi sarcoma, are also frequently associated with HIV infection, whereas laryngeal manifestations are rare. We report two cases of newly diagnosed HIV patients with clinical presentations of sore throat, and endoscopy revealed an epiglottic ulcerative tumor-like lesion. A laryngomicrosurgical biopsy of the lesions was performed for persistent symptoms and suspicion of malignancy. The result revealed acute and chronic inflammation without a conclusive pathology diagnosis. Further laboratory analysis was arranged in consideration of autoimmune diseases, Epstein–Barr virus (EBV), and HIV infection due to their persistent and atypical symptoms. The results were positive for HIV infection. These patients were treated successfully with antiviral treatment and the laryngeal symptoms improved within weeks. In patients with idiopathic and persistent epiglottitis or an epiglottic ulcer after medical treatment, HIV infection needs to be considered as a potential etiology in order to institute proper treatment.
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Buitinck, Sophie H., Matty Koopmans, Rogier M. Determann, Rogier R. Jansen, and Peter H. J. van der Voort. "Enteral Vancomycin to Eliminate MRSA Carriership of the Digestive Tract in Critically Ill Patients." Antibiotics 11, no. 2 (February 17, 2022): 263. http://dx.doi.org/10.3390/antibiotics11020263.
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Background: Carriership with methicillin resistant Staphylococcus aureus (MRSA) is a risk for the development of secondary infections in critically ill patients. Previous studies suggest that enteral vancomycin is able to eliminate enteral carriership with MRSA. Data on individual effects of this treatment are lacking. Methods: Retrospective analysis of a database containing 15 year data of consecutive patients from a mixed medical-(cardio)surgical 18 bedded intensive care unit was conducted. All consecutive critically ill patients with enteral MRSA carriership detected in throat and/or rectal samples were collected. We analyzed those with follow-up cultures to determine the success rate of enteral vancomycin. Topical application of 2% vancomycin in a sticky oral paste was performed combined with a vancomycin solution of 500 mg four times daily in the nasogastric tube. This treatment was added to a regimen of selective digestive tract decontamination (SDD) to prevent ICU acquired infection. Results: Thirteen patients were included. The mean age was 65 years and the median APACHE II score was 21. MRSA was present in the throat in 8 patients and in both throat and rectum in 5 patients. In all patients MRSA was successfully eliminated from both throat and rectum, which took 2–11 days with a median duration until decontamination of 4 days. Secondary infections with MRSA did not occur. Conclusions: Topical treatment with vancomycin in a 2% sticky oral paste four times daily in the nasogastric tube was effective in all patients in the elimination of MRSA and prevented secondary MRSA infections.
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Nakaseko, Haruna, Osamu Uemura, Takuhito Nagai, Satoshi Yamakawa, Yoshiko Hibi, Yasuhito Yamasaki, and Masaki Yamamoto. "High Prevalence of Sinusitis in Children with Henoch-Schönlein Purpura." International Journal of Pediatrics 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/562638.
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We evaluated the prevalence and the types of infectious foci in oral as well as ear, nose, and throat diseases, and we examined incidence of renal involvement with active treatment for focal infection in children with Henoch-Schönlein Purpura. A total of 96 children who presented at Aichi Children's Health and Medical Center and were diagnosed as having HSP were evaluated for infectious foci in the ear, nose, throat, and oral cavities. Seventy-one of 96 children (74.0%) had some type of infectious lesion, such as sinusitis or tonsillitis, and the prevalence of sinusitis was the highest (51 cases, 53.7%). In 44 HSP patients without renal involvement at the first examination, the incidence of nephritis was lower (13.6%) than in previous reports (17–54%) due to our aggressive intervention for infectious foci.
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Zakharova, I. N., N. A. Geppe, N. G. Sugyan, A. R. Denisova, and I. V. Berezhnaya. "Topical etiotropic drugs in therapy of infectious inflammatory diseases of pharynx in preschool children. Results of a multicenter randomized comparative clinical trial." Russian Otorhinolaryngology 20, no. 1 (2021): 102–17. http://dx.doi.org/10.18692/1810-4800-2021-1-102-117.
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In accordance with modern clinical guidelines, systemic antibiotic therapy for infectious and inflammatory diseases of the throat is recommended only when beta-hemolytic group A streptococcus is detected. In other cases, it is advisable to use topical drugs of etiotropic, pathogenetic and symptomatic action. The combined preparation Grammidin® has a wide spectrum of etiotropic activity (antiviral, antibacterial and antifungal). Objective of the study: to assess the safety and efficacy of the use of Grammidin® for children (dosage form – metered spray) in the treatment of inflammatory diseases of the pharynx in preschool children. Materials and methods. An open comparative multicenter randomized study was carried out in two parallel groups with the participation of 160 patients aged 3–5 years with an infectious-inflammatory disease of the pharynx of nonstreptococcal etiology. The disease was established clinically by the presence of: a symptom of «sore throat» according to the Wong-Baker (WB) scale, as well as two or more local signs of acute inflammation of the oropharynx (hyperemia of the pharyngeal mucosa, edema of the pharyngeal mucosa, edema of the soft tissues of the posterior and lateral pharyngeal walls, an increase in lymphoid granules of the posterior pharyngeal wall and lateral columns, swelling of the uvula) according to pharyngoscopy. The randomized patients received Grammidin® for children or Hexoral® for 7 days according to the instructions for medical use. Safety was assessed by the incidence of adverse events (AEs) and by monitoring vital signs (body temperature, blood pressure, respiration and heart rate) with monitoring of blood and urine tests. Efficacy was assessed by the decrease in mean disease severity (modified TSS) at visit 2 from baseline – the primary endpoint. Changes were used as secondary endpoints: the severity of the disease (TSS scale), the severity of the sore throat symptom (WB scale), the severity of each of the catarrhal symptoms initially identified according to pharyngoscopy data, the proportion of patients with no sore throat (WB scale), the proportion of patients with the absence of all catarrhal phenomena (pharyngoscopy) at visits 2 and 3. Results. Primary efficacy endpoint: change in mean disease severity on the TSS scale at Visit 2 from baseline in Group 1 was –1,80 (95% CI –1,98 – –1.61) points and –1,31 (95 % CI –1,50 – –1,12) points - in group 2 (p = 0.003). Secondary performance endpoints. According to the analysis of variance in Group 1, there was a statistically significant predominance of the therapeutic effect throughout the treatment in relation to the severity of the disease on the Total Symptoms Score (TSS) scale (p = 0,006), the severity of sore throat on the WB scale (p = 0,006), as well as the severity of individual signsof the disease: «Hyperemia of the pharyngeal mucosa» (p = 0,036) and «edema of the pharynx» (p = 0,037). The rates of relief of symptoms: «the severity of lymphoid granules of the posterior pharyngeal wall and lateral columns» and «uvula edema» were similar in both groups. The proportion of children with no sore throat at visit 2 was statistically significantly different: 46 and 29% for Group 1 and Group 2, respectively (p = 0,022). Safety assessment. In the course of the study, 1 child was registered in each group who developed 1 AE of mild severity, had a doubtful connection with the study drugs, did not require their cancellation and additional therapy, and spontaneously ended without consequences by visit 3. Conclusions. The combined drug Grammidin® for children in the form of a metered spray was well tolerated by children aged 3–5 years and according to a number of main criteria of efficacy (total severity of symptoms of the disease, sore throat, hyperemia and swelling of the pharyngeal mucosa) showed a pronounced and statistically significant advantage in speed and severity effect over a monocomponent preparation containing hexetidine in the form of an aerosol.
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Petersen, I. S., A. B. Zeuthen, J. M. Christensen, M. D. Bartels, H. H. N. Johansen, S. P. Johansen, J. O. Jarløv, D. Mogensen, and J. Pedersen. "Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study." Journal of Hospital Infection 119 (January 2022): 16–21. http://dx.doi.org/10.1016/j.jhin.2021.09.025.
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Tiotiu, Angelica, Davor Plavec, Silviya Novakova, Stefan Mihaicuta, Plamena Novakova, Marina Labor, and Andras Bikov. "Current opinions for the management of asthma associated with ear, nose and throat comorbidities." European Respiratory Review 27, no. 150 (November 21, 2018): 180056. http://dx.doi.org/10.1183/16000617.0056-2018.
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Ear, nose and throat (ENT) comorbidities are common in patients with asthma and are frequently associated with poorer asthma outcomes. All these comorbidities are “treatable traits” in asthma. Identification and management of these disorders may spare medication usage and contribute to improved asthma control and quality of life, and a decrease in exacerbation rates.This review summarises recent data about the prevalence, clinical impact and treatment effects of ENT comorbidities in asthma including allergic rhinitis, chronic rhinosinusitis with and without nasal polyposis, aspirin-exacerbated respiratory disease, obstructive sleep apnoea and vocal cord dysfunction.Many of these comorbidities are possible to be managed by the pulmonologist, but the collaboration with the ENT specialist is essential for patients with chronic rhinosinusitis or vocal cord dysfunction. Further rigorous research is needed to study the efficacy of comorbidity treatment to improve asthma outcomes, in particular with the development of biotherapies in severe asthma that can also be beneficial in some ENT diseases.
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Kirichenko, L. V., Yu N. Maslov, Vera P. Khokhryakova, S. A. Selivanova, V. G. Barannikov, and S. V. Dementev. "THE FEATURES OF APPLICATION OF MINERAL OF SYLVINITE IN COMPLEX TREATMENT OF ENT-DISEASES." Medical Journal of the Russian Federation 24, no. 2 (April 15, 2018): 87–92. http://dx.doi.org/10.18821/0869-2106-2018-24-2-87-92.
Full textAbstract:
The active implementation of sylvinite therapy in modern medical practice and appearance of new modifications of salt devices gave occasion to widening of area of application of this curative method. It is proposed to apply sylvinite physiotherapy room in complex treatment of chronic catarrhal pharyngitis as a most wide-spread disease of ENT-organs presented in all age groups and especially in persons of young age. The inner environment of facility was evaluated by hygienic methods. The levels of such curative factors impacting patients as aeroionization, multi-component fine-dispersed dry salt aerosol, stable micro-climate was within therapeutically significant limits. The in-depth microbiological analysis of inner environment of the given facility that substantiated availability of bacterio-static effect of mineral sylvinite on bacterial culture S.aureus and high efficiency of functioning of physiotherapy facility. The clinical studies covered 52 patients with chronic catarrhal pharyngitis: 27 - observation group (common treatment+syvinite therapy) and 25 - comparison group (common therapy only). In the result of applied treatment all patients achieved amelioration of health condition and local immunity of mucous membrane of throat. However, in the comparison group positive dynamics was less expressed. The obtained results confirmed possibility of application of characteristics of natural mineral sylvinite in complex treatment of chronic catarrhal pharyngitis and other inflammatory diseases of ENT-organs.
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Le-Le-Win, Thein-Hlang, San-Shwe, Than-Htun-Oo, and Ko-Ko-Tin. "Profile of Cataract Patients in the Eye, Ear, Nose and Throat Hospital, Rangoon." Tropical Doctor 19, no. 4 (October 1989): 189–90. http://dx.doi.org/10.1177/004947558901900423.
Full textAbstract:
We report on our experience of cataract surgery in the Eye, Ear, Nose and Throat Hospital (EENTH), Rangoon. Cataract patients constituted 52070 of all those admitted with eye diseases to the EENTH in a year. The mean number of cataract cases operated per month was 282. Among cataracts the senile form was the commonest. The female to male ratio for senile cataract patients was 1.2, and the average age at admission was 68 years. The mean duration of stay in hospital was 7 days with an operation time of 19min. The patients had to come to hospital for follow-up for an average period of 3.1 months to complete treatment. The need to consider cataract surgery as an outpatient procedure is discussed.