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1

Tan, Celia I. C. "A radiological and biochemical perspective on ageing and degeneration of the human thoracic intervertebral disc." University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0059.

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Disc degenerative changes are directly or indirectly associated with spinal pain and disability. Literature revealed a high prevalence of disc degeneration in the thoracic region, however thoracic MRI degeneration trends and information on disc biochemical matrix constituents are limited for thoracic discs compared to lumbar and cervical discs. The objective of this thesis was to use MRI to investigate the prevalence of disc degenerative changes affecting the human thoracic spine, and to determine the factors affecting spinal disc biochemical matrix. A 3-point subjective MRI grading scale was used to grade the films. The feasibility of using archived formalin-fixed cadaver material was investigated to analyse collagen and elastin crosslinks. The prevalence of degenerative changes in human thoracic discs and vertebrae (T1 to T12) was determined retrospectively from an audit of 216 MRI cases, using sagittal T1- and T2-weighted MR images. In a subsequent series of ex-vivo studies, human thoracic discs and LF from 26 formalin-fixed and two fresh spines, involving all thoracic levels, were examined macroscopically to determine the degeneration status. Subsequently, disc and ligament tissues were analysed biochemically for collagen (pyridinoline and deoxypyridinoline) and elastin (desmosine and isodesmosine) crosslinks. These crosslinks were extracted from hydrolysed samples by cellulose partition chromatography, and analysed by reverse-phase HPLC. Collagen content was determined using its hydroxyproline content, and proteoglycan content was assayed using a modified DMB assay for chondroitin sulphate. Finally the MRI and macroscopic assessments of thoracic discs, were compared with the biochemical data from two fresh cadaver thoracic spines. The 3-point MRI grading scale had a high inter- (k = 0.57 to 0.78) and intra-rater (k = 0.71 to 0.87) reliability. There were no significant differences in the collagen and elastin content and extent of collagen crosslinks between formalin fixed and unfixed ligament and disc tissues, after 25 weeks of formalin fixation. From the in-vivo MRI series of investigations (n = 216 MRI films), the prevalence of thoracic disc degenerative and vertebral morphological changes revealed significant age, gender and spinal level trends (p < 0.05).Generally, males had a higher propensity for disc degeneration in contrast to females, especially older females, where the trend showed a higher prevalence of osteophytes and vertebral body changes. In particular, the mid and lower thoracic levels have a higher prevalence of degenerative changes, except for osteophytes and anterior vertebral wedging. With increased age, there was a concomitant increase in anterior wedging and bi-concavity and disc degenerative changes except for end-plates. The biochemical investigations on the ex-vivo series of formalin-fixed thoracic discs (n = 303) also revealed significant changes in the disc matrix due to degeneration status, age, gender and spinal regional factors. With increased age, normal disc matrices have significantly lower collagen content and extent of pyridinoline (p < 0.001). In contrast, the degenerated disc matrix revealed significantly higher collagen content and extent of deoxypyridinoline (p < 0.05). These findings suggest that an altered matrix existed in normal ageing discs, which render the disc prone to injury and degeneration over the life span. The higher collagen and deoxypyridinoline in degenerated disc matrices reflects an increase in chondrocyte synthesis, and is also a novel finding, suggesting that they may be used as markers of ageing and degeneration processes. The biochemical investigations on another series of ex-vivo spinal LF tissues (n = 364), revealed that this had a lower collagen and pyridinoline, but significantly higher elastin and deoxypyridinoline compared to spinal discs (p < 0.05). Elastin crosslinks however were difficult to detect in spinal discs, being present in negligible amounts in a few lumbar discs. The elastin crosslinks in the LF were not significantly affected by age, but were significantly higher in calcified, and female ligamentum tissues, and also in the lumbar region (p < 0.05). These MRI prevalence findings enhanced our knowledge of vertebral body and disc degeneration trends in the thoracic region and contributed to the interpretation of MR images for pathology in the human thoracic spine. Information on the associated collagenous and elastic changes in the disc and ligamentum matrices provide original data and insight on the pathogenesis of degeneration in the disc matrix from a biochemical perspective, highlighting gender, age and spinal level influences on the matrix tensile strength and cellular synthetic activities.
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2

Loomis, David Arthur. "A Biomechanical Analysis of Ape and Human Thoracic Vertebrae Using Quantitative Computed Tomography Based Finite Element Models." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1260218025.

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Thesis(M.S.)--Case Western Reserve University, 2009
Title from PDF (viewed on 2010-01-28) Department of EMC - Mechanical Engineering Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center
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3

Cortez-Bazán, Nathaly, Jennifer R. Delgado, Omar Galdos, and Luis Huicho. "Pott’s disease in upper thoracic vertebrae in atwo-year-old boy: Case report." Instituto Nacional de Salud, 2018. http://hdl.handle.net/10757/624633.

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Pott’s disease is a health problem in developing countries and its diagnosis in children is a challenge. Here we present the case of a two-year-old boy with Pott’s disease involving T1 to T3 thoracic vertebrae. The clinical presentation was characterized by difficulty walking, fever, cough, and dyspnea. At physical examination, kyphosis and bony prominence were observed in the cervicodorsal area. A positive tuberculin test was obtained, and Mycobacterium tuberculosis was isolated via culture of the gastric aspiration sample. The spine MRI showed a chronic abscess, destruction of two vertebrae, and bone marrow compression. The patient experienced some improvement with anti-TB therapy. Here, we emphasize the importance of giving consideration to the clinical suspicion for the early detection of this condition, as well as a quick TB-treatment start so as to avoid the disability and mortality associated to this disease.
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4

Botha, René. "Demonstrating the cervicothoracic junction : a comparison of two techniques." Thesis, Bloemfontein : Central University of Technology, Free State, 2008. http://hdl.handle.net/11462/113.

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Thesis (M. Tech.) -- Central University of Technology, Free State, 2008
Motivated by the challenges associated with demonstrating the cervicothoracic junction, a study was conducted at Pelonomi Regional Hospital from May 2006 to June 2007. In this study, two projections of the cervicothoracic junction were done, with the only difference between them being the orientation of the arms. One projection was done using the swimmer’s projection and the other using an adaptation of the swimmer’s projection where the orientation of the arms was reversed. The sample, consisting of 45 patients, was referred from the emergency department and wards. Most of the patients (95.5%) were examined using a computed radiography system providing digital images that were printed using a laser film printer. Other patients were examined using conventional film/screen systems. The objectives of this study were to compare the two imaging techniques with reference to diagnostic quality of the projections, diagnosis of pathology and repeat rate. Radiographers obtained the two projections of the cervical spine; the researcher collected the images and distributed these to three participating radiologists on a rotational basis. The radiologists evaluated the films using a set of criteria; a biostatistician analysed the results of these evaluations. In all the criteria of image quality the swimmer’s projection showed better results. There were also, however, instances where the adapted swimmer’s had better results. The differences in percentages were not significant enough to show any statistical difference between the resultant images of the two techniques. No valid deduction could be made in relation to the demonstration of pathology due to variable instances of pathology evaluated by the radiologists. The repeat rate of the adapted swimmer’s projection compared well with the swimmer’s projection. Though the swimmer’s projection had better results for most of the criteria used in this study, no unequivocal, statistically significant evidence of it demonstrating C7-T1 better could be found. What was evident was the validity of the adapted swimmer’s projection as an alternative under certain conditions. Knowing that there is an alternative method to visualising the C7- T1 junction could be beneficial not only to radiography, but also to our patients. In cases where the swimmer’s projection is not possible due to extremity injuries, an alternative arm orientation can be useful. The alternative can also address the problem regarding multiple repeats of the swimmer’s projection.
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5

De, Donno Giulia. "Three dimensional strain analysis of vertebrae with artificial metastases through digital volume correlation." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/19911/.

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Bone is a common site for metastases and spine represent the most frequent site. Lytic lesions are associated with the loss of bone tissue, which can compromise the mechanical competence of the vertebra, leading to spine instability. Rigid stabilization is a solution, but it is a complex surgery, that can be very critical for oncologic patients; on the other hand, an untreated metastasis can lead to mechanical failure of the bone, leading to pain, immobilization and in the worst case, paralysis. In this study, a protocol to analyse the strain with simulated lytic metastasis under compressive loading has been developed and optimized using a porcine vertebra. The strain distribution has been measured experimentally using micro-computed tomography (micro-CT) and Digital Volume Correlation (DVC), which provided three-dimensional displacements and strains maps inside the specimen. The ideal parameters for the DVC have been found by analysing two repeated scans in constant strain condition and setting a target of 200 microstrain for the errors (one order of magnitude lower than typical strains in bone subjected to physiological loading conditions). An ideal nodal spacing of 50 voxels (approximately 2 mm) has been chosen and a voxel detection algorithm has been applied to all data to remove regions outside the bone. In order to understand how the presence of the defect could alter the strain distribution, the porcine vertebra has also been subjected to non-destructive compressive load before and after the preparation of a mechanically induced lytic metastasis in the vertebral body. An increase of the 40% of the compressive principal strain after the defect has been found in proximity of the lesion. This protocol will be used in future studies to analyse the effect of size and position of artificially metastatic lesions in the vertebral body of human spines.
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6

Dare, Michael Robert. "Investigation of hip kinematics in adult sports participants during single leg drop landing with chronic groin pain." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86334.

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Thesis (MScPhysio)--Stellenbosch University, 2014.
ENGLISH ABSTRACT: Introduction-Groin injuries are among the top six most cited injuries in soccer and account for 10-18 per cent of all injuries reported in contact sport. Groin pain can result from a variety of pathologies, but according to literature, 63 per cent of groin pain is due to adductor pathology. Objective-The objective of this study was to explore if there are kinematic differences in the hip joint in sports participants with groin pain compared to matched healthy controls. Study design A cross sectional, descriptive study was conducted. Study setting-The study was conducted at the FNB -3D motion analysis laboratory at the University of Stellenbosch, South Africa. Outcome variables-The dependent variables included hip kinematics in the sagittal, frontal and transverse planes at foot strike, lowest vertical point of the pelvis and total range of hip motion during a single leg drop landing. Methodology-The study sample comprised 20 male club level soccer-and, rugby players, running and cycling participants between the ages of 18-55 years of age. Ten of the subjects had chronic groin pain and the other ten were healthy matched controls. An eight-camera Vicon system was used to analyse the kinematics of the hip joint during single leg drop landing. For the purpose of comparison, the data was analysed for participants with unilateral groin pain and matched controls (n=14) and participants with bilateral groin pain and controls (n=6). The full set of data was subdivided for analysis into three distinct sub-groups. Unilaterally injured groin cases (n=7) were matched with seven healthy controls for analysis. Bilaterally injured groin cases (n=3) were matched with three healthy controls. Results-Cases with unilateral groin pain at initial contact had significantly more abduction of the hip joint when compared to controls (p<0.05). The effect size of this difference was large (0.94). Cases with unilateral groin pain also demonstrated greater hip internal rotation while the controls had external rotation (p<0.05) during a drop landing activity. Bilaterally injured groin cases landed with significantly (p=?) greater ranges of hip flexion as well as in significantly (p=?) more hip abduction during a drop landing activity. They also demonstrated greater total range of motion in the frontal plan when compared to controls. Groin pain cases overall demonstrated greater ranges of motion and tended to land in more abduction compared to controls. Conclusion-This study found that during a single leg drop landing, sports participants with unilateral chronic groin pain landed with significantly greater hip abduction and exhibited larger total range of motion in the transverse plane, which may indicate impaired stability of the hip complex when compared to controls.
AFRIKAANSE OPSOMMING: Inleiding-Liesbeserings is een van die top ses mees prominente sokker beserings. Dit beloop 10-18 persent van alle beserings wat in kontaksport aangemeld word. Liespyn kan die gevolg wees van ‘n verskeidenheid patologië, maar volgens die literatuur is 63 persent van liespyn as gevolg adduktor patologie. Doelwitte-Die doelwit van hierdie studie was om ondersoek in te stel of daar enige kinematiese veranderinge in die heupgewrig is in spelers met liespyn in vergelyking met dieselfde vergelykbare spelers sonder liespyn. Studie Ontwerp-‘n Deursnit, beskrywende studie was onderneem. Studie Omgewing-Die studie was uitgevoer by die FNB-3D bewegingsanalise laboratorium van die Stellenbosch Universiteit, Suid-Afrika. Uitkomsveranderlikes-Die afhanklike veranderlikes het in gesluit die heup kinematika in die sagitale, frontale en transvers vlakke met voet kontak endie laagste vertikale punt van die pelvis sowel as die totale heup omvang van beweging gedurende een been landing. Metodologie-Die studie populasie het bestaan uit 20 manlike sokker- en, rugbyspelers, hardlopers en fietsryers tussen die ouderdomme van 18 en 55 jaar. Tien van die deelnemers het kroniese liespyn gehad en die ander tien in die gelyke gesonde groep was sonder liespyn. Die agt kamera Vicon sisteem was gebruik om die kinematika van die heupgewrig te analseer tydens een been landing. Vir die doel om ‘n vergelyking te kan maak, was die data geanaliseer van deelnemers met unilaterale liespyn en die vergelykende groep sonder liespyn (n=14) en deelnemers met bilaterale liespyn en hulle vergelykende groep sonder liespyn (n=6).. Die volledige stel data was onderverdeel in drie afsonderlike sub groepe. Vir die analiese was unilaterale liesbeserings (n=7) vergelyk met sewe deelnemers sonder liespyn in die kontrolegroep. Deelnemers met bilaterale liesbeserings (n=3) was vergelyk met drie in die kontrolegroep. Resultate-Die deelnemers met unilaterale liespyn het met eerste kontak beduidend meer abduksie van die heupgewrig gehad in vergelyking met die kontrolegroep (p<0.05). Die effek van hierdie verskil was groot (0.94). Die deelnemers met unilaterale liespyn het ook ‘n grooter interne rotasie getoon, terwyl die kontrole groep meer eksterne rotasie gedemonstreer het (p<0.05) met landing. Deelnemers met bilaterale liespyn het beduidend (p=?) meer heup fleksie en abduksie omvang van beweging tydens landing. Hulle het ook ‘n groter totale heup omvang van beweging in die frontale vlak gehad in vergelyking met die kontrolegroep. Deelnemers met liespyn het oor die algemeen ‘n grooter omvang van beweging getoon, en was geneig om met meer abduksie van die heup te land as die kontrolegroep. Gevolgtrekking-Die studie toon dat deelnemers met kroniese unilaterale liespyn, tydens een been landing, beduidende meerheup abduksie toon en dat die heup in die transverse vlak meer totale omvang van beweging gebruik wat kan dui op onstabiliteit in die heupkompleks in vergelyking met die kontrolegroep.
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7

Fujii, Kota. "Association of Chemoradiotherapy With Thoracic Vertebral Fractures in Patients With Esophageal Cancer." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/264656.

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8

Sugino, Rafael Lindi. "Estudo morfométrico da coluna vertebral torácica: relação da transição cervicotorácica com o esterno." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17142/tde-08062017-095810/.

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A transição cervicotorácica compreende a região anatômica que envolve as vértebras cervicais distais e as torácicas proximais. Durante a realização de abordagens cirúrgicas anteriores para tratamento de afecções que acometem as vértebras desta região, o esterno pode representar uma barreira mecânica. Assim, diversos métodos de programação pré-operatório foram propostos para avaliar a necessidade de osteotomias do esterno. Até a presente data, não existem trabalhos correlacionando as medidas com as variáveis sexo e idade. Nosso estudo envolveu a avaliação retrospectiva de 300 exames de tomografia computadorizada. Os pacientes foram separados de acordo com o sexo em dois grupos e de acordo com a faixa etária em 3 subgrupos. Os parâmetros estudados foram: nível horizontal em relação ao esterno (NHE), angulação do corpo (AC), nível discal (ND) e angulação do nível discal (AND). O NHE variou de C7 a T4, sendo mais frequente o nível T2 (34,3%). Os NHE menos frequentes foram T4 (0,3%) e C7 (1%). A AC e AND evidenciaram uma média de 18,51o e 19,63o, respectivamente. O AC variou de 1,29o a 54,32o, enquanto o AND variou de 0o a 49o. O ND variou de C5-C6 a T2-T3, sendo C7-T1 o ND mais frequente com 46%. O ND menos frequente foi encontrado nos níveis T2-T3 (1,7%) e C5-C6 (3%). Comparado o AND entre os grupos masculino e feminino, encontramos diferença estatística (p=0,003), sendo maior no grupo masculino. Houve diferença estatisticamente significante quando comparado os valores da AND entre os grupos etários (p=0,01). Com relação a AC, encontramos diferença estatística entre os grupos dos sexos masculino e feminino (p=0,02), sendo maior no grupo masculino. A comparação do AC entre os grupos de diferentes faixas etárias demonstrou uma diferença estatística (p=0,001). Não houve diferença quando comparados os resultados do NHE entre os grupos masculino e feminino (p=0,3), nem comparando valores de NHE entre as diferentes faixas etárias (p=0,79). O ND e NHE de nossa amostra da população brasileira apresenta valores menores quando comparados à outras amostras populacionais. O ND apresentou diferenças entre os grupos etários, sendo que quanto mais velho o grupo, menor eram os valores. Os nossos resultados evidenciaram que o nível discal mais distal acessível com a realização de abordagem anterior à região cervicotorácica da coluna vertebral, sem a teórica necessidade de uma osteotomia do esterno, apresenta valores menores quando comparados aos dados previamente relatados atribuídos a outras populações. Em outras palavras, este achado pode ser traduzido como se os pacientes envolvidos no estudo apresentassem um menor número de vértebras passíveis de serem abordadas por meio de procedimento cirúrgico anterior sem a realização de osteotomia do esterno. Desta forma, o mesmo raciocínio pode ser aplicado para o nível horizontal em relação ao esterno, pois nossos resultados apresentaram valores mais craniais, comparados aos resultados de estudos prévios. Além disso, o nível discal apresentou diferença quando comparamos os pacientes de diferentes faixas etárias, sendo que, quanto maior a faixa etária, menor foram os valores encontrados. Este achado representa uma migração para cranial do nível discal mais distal, conforme aumentamos a faixa etária dos pacientes estudados
The cervicothoracic transition comprises the anatomical region including the distal cervical and proximal thoracic vertebrae. While conducting anterior surgical approaches for treatment of conditions that affect the vertebrae in this region, the sternum may represent a mechanical barrier. Thus, various methods of preoperative programming have been proposed to assess the need for osteotomies of the sternum. To date, there are no studies correlating the measures with gender and age. Our study involved a retrospective review of 300 CT examinations. Patients were separated according to gender into two groups and according to age into 3 subgroups. The studied parameters were: horizontal level in relation to the sternum (LHS), vertebral body angle (VA), disc level (DL) and angulation of the disc level (ADL). The LHS ranged from C7 to T4, and T2 was the most frequent (34.3%). The less frequent LHS were T4 (0.3%) and C7 (1%). The AC and ADL showed an average of 18,51o and 19,63o respectively. The VA varied 1,29o the 54,32o, while the ADL varied from 0o to 49o. DL ranged from C5-C6 to T2-T3, being C7-T1 the most frequent (46%). The less frequent DL found were T2-T3 (1.7%) and C5-C6 (3%). Compared the ADL between male and female groups, we found statistically significant difference (p = 0.003), being higher in the male group. There was a statistically significant difference when compared the values of ADL between the groups (p = 0.01). Regarding VA, we found statistically significant differences between male and female groups (p = 0.02), being higher in the male group. Comparison of VA between groups of different age showed a statistically significant difference (p = 0.001). There was no difference when comparing the results of the LHS between male and female groups (p = 0.3), or comparing LHS values between the different age groups (p = 0.79). The DL and LHS in our sample of the population has lower values compared to other population samples. DL differ between age groups, and the older the group, the lower were the figures. Our results show that the most distal disc level accessible from an anterior approach to the cervicothoracic region of the spine, with no theoretical need for a sternal osteotomy, present lower values when compared to previously reported data assigned to other populations. In other words, this finding can be translated as if the enrolled patients presented fewer vertebrae that can be addressed through anterior surgical procedure without performing sternal osteotomy. Thus, the same thought can be applied to the horizontal level in relation to the sternum, since our results showed more cranial values compared to results of previous studies. In addition, the disc level was different when comparing patients of different age groups, and the higher the age, the lower were the values found. This finding represents a migration to the more distal cranial disc level, as we increase the age of the patients
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Voisin, Meghan Dawn. "Sexual dimorphism in the 12th thoracic vertebra and its potential for sex estimation of human skeletal remains." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/3991.

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The purpose of this study is to determine the presence/degree of sexual dimorphism of the 12th thoracic vertebra through a quantitative analysis and to further examine its potential and reliability in the sex estimation of human skeletal remains. This study also explores the age-related changes of human skeletal remains and how these affect morphological variation conducive to sex estimation. In order to assess this, the 12th thoracic vertebrae, femur and sacrum of 168 mature skeletal remains (94 males and 74 females) from the Raymond Dart Collection in Johannesburg, South Africa and 407 (205 males and 202 females) mature skeletal remains from the Hamann-Todd Collection in Cleveland, Ohio were analyzed. Only individuals whose group affiliation was designated as “South African Black” from the Raymond Dart Collection and “African American” from the Hamann-Todd Collection were measured. This was done to permit the examination of geographical variance within and between the two samples. The morphology of the 12th thoracic vertebra was examined by means of univariate and multivariate analyses to better assess each effect. These analyses resulted in relatively high correct classifications of males and females in all samples, with mean measurement values being larger in males in all measurements. While age-related changes have little effect on the high reliability of sex estimation in the African American sample, age-related changes decreases the reliability of sex estimation in the South African sample. Overall, this study reveals that the 12th thoracic vertebra has potential for use in sex estimation as a result of the skeletal morphological variation between males and females both documented in the Raymond A. Dart Collection of Human Skeletons and the Hamann-Todd Osteological Collection.
Thesis (M.A.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Anthropology.
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Pinto, Inês Isabel Ramos. "Comparison of heart measurements in thoracic radiographs before and after the treatment of pulmonary edema in dogs with degenerative mitral valve disease : a retrospective study of 18 clinical cases." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/18204.

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Dissertação de Mestrado Integrado em Medicina Veterinária
The Degenerative Mitral Valve Disease (DMVD) has the highest prevalence of all canine heart diseases accounting for 75-80% of the cases of dogs with cardiac disease. DMVD is characterized by having an evolutive nature. As the disease progresses the microscopic and macroscopic alterations of the mitral valve’s apparatus become more severe and gradually start preventing the valve’s normal function. One of the complications that may occur is the development of pulmonary edema. Overt pulmonary edema occurs when the capacity of the pulmonary lymphatic system is exceeded, leading to an increase in the extravascular water content of the lungs. The etiology and consequently the cure for DMVD are not currently known, hence the importance of understanding and developing tools that allow the monitoring of the disease. Even though the best way to assess and confirm the diagnosis of DMVD is through echocardiography, this exam requires additional expertise to be performed and interpreted, as well as substantial financial costs to the owner. Simultaneously, radiography of the thorax is widely available and cost-effective, which justifies the interest in studying the evolution of the radiographic measures Vertebral Heart Score (VHS) and Vertebral Left Atrium Size (VLAS) in dogs with DMVD. This retrospective study aims to compare heart measurements in thoracic radiographs before and after the treatment of pulmonary edema in 18 dogs with DMVD that were submitted to consultation in a french veterinary referral center. The main conclusion of this study is that the size of the left atrium and the cardiac silhouette decreases after the resolution of cardiogenic pulmonary edema when compared to the dimensions during its occurrence. Furthermore, this decrease in the left atrium’s size is detectable using the VLAS method, which confirms its value in monitoring the progression of the disease. Consequently, it is possible for those who do not have access to an echocardiographic exam, to use the VLAS method to follow the evolution of the left atrium’s size throughout the progression of DMVD. It was also verified that VLAS measurements have a positive correlation with echocardiographic measures of the left atrium, implying that when one increases the other does so as well, and vice-versa.
RESUMO - Comparação de medições cardíacas em radiografias torácicas antes e depois do tratamento de edema pulmonar em animais com Doença Degenerativa da Válvula Mitral: um estudo retrospetivo de 18 casos clínicos - A Doença Degenerativa da Válvula Mitral (DDVM) tem a prevalência mais alta de todas as doenças cardíacas caninas, representando 75-80% dos casos destes doentes. A DDVM é caracterizada pela sua natureza evolutiva. Assim à medida que a doença progride, as alterações microscópicas e macroscópicas da válvula mitral tornam-se mais graves e começam gradualmente a impedir o seu normal funcionamento. Uma das complicações que pode ocorrer é o desenvolvimento de edema pulmonar que sucede quando a capacidade do sistema linfático do pulmão é excedida, levando, por isso, à acumulação de conteúdo aquoso no compartimento extravascular dos mesmos. A etiologia e consequentemente a cura da DDVM não são atualmente conhecidas, dai a importância em perceber e desenvolver ferramentas que permitam a monitorização da doença. Embora a melhor maneira de determinar e confirmar o diagnóstico de DDVM seja através de uma ecocardiografia, este exame de diagnóstico representa um investimento para o proprietário, necessita de material caro e exige um nível de competência mais elevado para o realizar e interpretar. Simultaneamente, a realização de radiografias do tórax é uma técnica amplamente disponível e económica, o que justifica o interesse em estudar a evolução das medidas radiográficas Vertebral Heart Score (VHS) e Vertebral Left Atrium Size (VLAS) em cães com DDVM. O objetivo deste estudo retrospetivo prende-se com a comparação de medidas cardíacas, em radiografias da cavidade torácica, antes e depois do tratamento de edema pulmonar em 18 cães com DDVM que foram apresentados em consulta num centro hospitalar veterinário de referência francês. A principal conclusão deste estudo indica que o tamanho do átrio esquerdo e da silhueta cardíaca diminui depois da resolução do edema pulmonar de origem cardíaca, quando comparado com as dimensões durante a sua ocorrência. Adicionalmente, esta diminuição de tamanho do átrio esquerdo é detetável utilizando o método VLAS, o que confirma o seu valor na monitorização da progressão da doença. Consequentemente, é possível para aqueles que não têm acesso a um exame ecocardiográfico, utilizarem o método VLAS para seguir a evolução do tamanho do átrio esquerdo durante a progressão da DDVM. Também se verificou que as medições VLAS têm uma correlação positiva com as medidas ecocardiográficas do átrio esquerdo, o que implica que quando uma medida aumenta a outra aumenta também, e vice-versa.
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11

Shillington, Mark Pernell. "Anterior vertebral stapling for the fusionless correction of scoliosis." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/30421/1/Mark_Shillington_Thesis.pdf.

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Fusionless scoliosis surgery is an emerging treatment for idiopathic scoliosis as it offers theoretical advantages over current forms of treatment. Currently the treatment options for idiopathic scoliosis are observation, bracing and fusion. While brace treatment is non-invasive, and preserves the growth, motion, and function of the spine, it does not correct deformity and is only modestly successful in preventing curve progression. In adolescents who fail brace treatment, surgical treatment with an instrumented spinal fusion usually results in better deformity correction but is associated with substantially greater risk. Furthermore in younger patients requiring surgical treatment, fusion procedures are known to adversely effect the future growth of the chest and spine. Fusionless treatments have been developed to allow effective surgical treatment of patients with idiopathic scoliosis who are too young for fusion procedures. Anterior vertebral stapling is one such fusionless treatment which aims to modulate the growth of vertebra to allow correction of scoliosis whilst maintaining normal spinal motion The Mater Misericordiae Hospital in Brisbane has begun to use anterior vertebral stapling to treat patients with idiopathic scoliosis who are too young for fusion procedures. Currently the only staple approved for clinical use is manufactured by Medtronic Sofamor Danek (Memphis, TN). This thesis explains the biomechanical and anatomical changes that occur following anterior vertebral staple insertion using in vitro experiments performed on an immature bovine model. Currently there is a paucity of published information about anterior vertebral stapling so it is hoped that this project will provide information that will aid in our understanding of the clinical effects of staple insertion. The aims of this experimental study were threefold. The first phase was designed to determine the changes in the bending stiffness of the spine following staple insertion. The second phase was designed to measure the forces experienced by the staple during spinal movements. The third and final phase of testing was designed to describe the structural changes that occur to a vertebra as a consequence of staple insertion. The first phase of testing utilised a displacement controlled testing robot to compare the change in stiffness of a single spinal motion segment following staple insertion for the three basic spinal motions of flexion-extension, lateral bending, and axial rotation. For the second phase of testing strain gauges were attached to staples and used to measure staple forces during spinal movement. In the third and final phase the staples were removed and a testing specimen underwent micro-computed tomography (CT) scanning to describe the anatomical changes that occur following staple insertion. The displacement controlled testing showed that there was a significant decrease in bending stiffness in flexion, extension, lateral bending away from the staple, and axial rotation away from the staple following staple insertion. The strain gauge measurements showed that the greatest staple forces occurred in flexion and the least in extension. In addition, a reduction in the baseline staple compressive force was seen with successive loading cycles. Micro-CT scanning demonstrated that significant damage to the vertebral body and endplate occurred as a consequence of staple insertion. The clinical implications of this study are significant. Based on the findings of this project it is likely that the clinical effect of the anterior vertebral staple evaluated in this project is a consequence of growth plate damage (also called hemiepiphysiodesis) causing a partial growth arrest of the vertebra rather than simply compression of the growth plate. The surgical creation of a unilateral growth arrest is a well established treatment used in the management of congenital scoliosis but has not previously been considered for use in idiopathic scoliosis.
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12

Kryvetskyi, V. V. "Peculiarities of morphogenesis and topography of the thoracic part of the vertebral column in the prenatal period of human ontogenesis." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17574.

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13

PUCH, JEAN-MARC. "Devenir de la stenose residuelle du canal vertebral dans les fractures comminutives du rachis thoraco-lombaire et lombaire : a propos de 19 cas." Nice, 1991. http://www.theses.fr/1991NICE6811.

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14

Rebeis, Eduardo Baldassari. "Índice antropométrico para "pectus excavatum" como método diagnóstico e de avaliação pré e pós-operatória: análise comparativa com o índice de Haller e o índice vertebral inferior." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-17082005-123221/.

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Estamos propondo um índice antropométrico para pectus excavatum correlacionando-o ao índice de Haller e ao índice vertebral inferior. Estudamos 20 pacientes com deformidade e 30 indivíduos normais. Os pacientes portadores do defeito torácico foram submetidos à correção cirúrgica. A correlação entre os índices foi alta, a acurácia semelhante e houve diferença significante entre o pré e pós-operatório estabelecida pelos índices.
We are proposing an anthropometric index for pectus excavatum correlating it to Haller's index and to the lower vertebral index. We have studied 20 patients with deformity and 30 normal patients. Patients carrying thoracic defect were submitted to surgical correction. The correlation between the indexes was high, the accuracy was similar and there was significant difference between the pre and post-operative established by the indexes.
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15

Ayoub, Sabah. "Translocation du calcium par les mitochondries du muscle long dorsal chez le porc normal et chez le porc sensible au "stress"." Clermont-Ferrand 2, 1987. http://www.theses.fr/1987CLF2D205.

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16

Kao, Yu-Chun, and 高于珺. "The Evaluation of Fatigue Behavior of Porcine Thoracic Vertebrae." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/6r76se.

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碩士
國立臺灣科技大學
機械工程系
95
Daily activities produce fatigue loading act on spine, and has been known to be one of the major causes of spinal degradation. Thus the effect of fatigue loading upon spine has been quite well studied, such as the fatigue property of disc, fatigue behavior variation due to different type of loading. However, research covering the significant factors which affect the fatigue behavior of a single vertebral body are still lacking. Therefore, this study has focused on investigating the biomechanical response due to the variation of the loading magnitude and frequency. Statistical methods have been employed to evaluate the significant factors influencing the fatigue behavior. One point of specific interest has been whether there is a significant relationship between the loading magnitude and the frequency which affects the fatigue behavior while combined under dynamic loading. In this study, 54 porcine thoracic spine vertebrae specimens were dissected. Both of loading magnitude and frequency were tested in 3 levels. The test levels of loading magnitude are 20-60%, 20-70% and 20-80% of critical load, the frequency are 0.5 Hz, 1 Hz and 2 Hz. Load-Displacement data was collected, and the variation of the displacement-cycle, the multi-cycle stiffness and the total displacement within 3600 cycles was then calculated. Finally, the correlation between the control factors and the experimental results were investigated. The fatigue behavior of the specimens were evaluated through the following parameters: the failure of specimen (D); the stiffness at initial state (Si); the number of cycles before reaching a steady state (Nss); the stiffness at steady state (Sss); the total number of cycles (Nend); the specimen stiffness after cyclic fatigue (Send); the total displacement (Disp); the ratio of the stiffness at steady state and that at the tenth cycle (Rss/i); and finally, the ratio of the stiffness at the end cycle and that at steady state (Rend/ss). According to the results, the stiffness before reaching steady state is significantly influenced by the loading magnitude. However, variations in frequency did not affect the stiffness of the vertebrae in this study, and furthermore there is no interaction between loading magnitude and frequency. Moreover, the risk of vertebral failure has not been found to directly relate to the loading magnitude and frequency.
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17

Nurcombe-Thorne, Andrew. "The effect of thoracic spinal manipulative therapy on lung function in subjects with thoracic facet syndrome." Thesis, 2009. http://hdl.handle.net/10210/2839.

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18

Benade, Maria Magdalena. "Thoracic and lumbar vertebrae of African hominids ancient and recent: morphological and fuctional aspects with special reference to upright posture." Thesis, 2016. http://hdl.handle.net/10539/20646.

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A Dissertation Submitted to the Faculty of Science University of the Witwatersrand, Johannesburg for the Degree of Master of Science January, 1990
This is a study of the morphological and functional aspects of A. africanus thoracic and lumbar vertebrae in comparison with those of modern human and anthropoid ape vertebrae. The purpose is to determine if any derived features in the morphology of hominids, as distinct from primitive features shared with non-hominids, were present and if so to what stage of attainment of full erectness such features point. The major results of this study are as follows: (i) There is a difference in the configuration of the lumbar articular facets between pongids, on the one hand, and modern human and A. africanus, on the other hand. This difference suggests that similar stresses operate in these regions in the two hominid groups. (ii) Bony adaptation to a developed lumbar lordosis is present in A. africanus. (iii) Major agreement has been found in the relative dimensions of modern human and A. africanus lumbar vertebrae, in contrast to those of pongid vertebrae. This indicates probable correspondence in the pattern of weight transmission to the pelvis in modern humans and A. africanus. (iv) The decrease of inferior lumbar vertebral body area starts at higher levels in sts 14 (an A. africanus partial skeleton) than in modern man, suggesting a longer curved lower lumbar region in A. africanus. From these results it may be concluded that the trunk was probably carried in a fully erect posture in A. africanus. The bony adaptation thereto, however, may not have been fully developed as in modern man. It is proposed that, in Sts 14, the last two lumbar vertebrae were carried at an angle relative to each other and to the sacrum, in contrast to the abrupt change in direction between L5 and the sacrum in modern man.
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19

Dimopoulos, Alex Illya. "The effect of spinal manipulation as compared to passive oscillatory mobilization in thoracic spine range of motion and pain, in patients with chronic mechanical thoracic spine dysfunction." Thesis, 2002. http://hdl.handle.net/10321/278.

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Thesis (M.Tech.: Chiropractic) -Dept. of Chiropractic, Durban Institute of Technology, 2002. xvi, 125 leaves
The purpose of this study was to determine the effect of spinal manipulation as compared to passive oscillatory mobilization, on thoracic spine range of motion, pain threshold and subjective pain experience, in patients with chronic mechanical thoracic spine dysfunction.
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20

Vaughn, Daniel W. "The effectiveness of a prescriptive therapeutic exercise program as an intervention for excessive thoracic kyphosis." 2005. http://www.oregonpdf.org.

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Thesis (Ph. D.)--Michigan State University, 2005.
Includes bibliographical references (leaves 307-322). Also available online (PDF file) by a subscription to the set or by purchasing the individual file.
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21

Nalla, Shahed. "The morphology of the upper thorax of Australopithecus Sediba within the context of selected hominoids." Thesis, 2014.

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The thoracic skeletal morphology of homininae is poorly known and understood. As a result of the representative fossil record of ribs and vertebrae being rare, distorted, fragmentary or unrecognised even when recovered, very little is known about the variability of rib and vertebral morphology when compared to the other cranial and postcranial elements in this lineage. Yet the costal skeleton forms a substantial part of the postcranial skeleton and thus ribs and vertebrae are therefore potentially numerous in the fossil record; but in comparison with other skeletal elements, and for the reasons mentioned above, very little is known about vertebrate and especially hominin rib morphology. The assessment of the structure of the thoracic skeletal elements and its evolutionary and ecological significance, particularly in the Homininae, poses a challenge but is still important as the shape and form of the rib cage has numerous functional and behavioural implications. The present study analysed the ribs of selected primate and non-primate mammalian species by examining fifteen variables, seven indices and eight osteological non-metric features. These observations and measurements were compared to ribs found in the fossil record in order to determine if there are any structural correlates between the extant and the extinct hominin and mammalian species and in order to create a template for the identification of hominin ribs within an abundant and diverse mammalian assemblage. The results suggest that the 1st rib, due to its unique morphology, may be considered most diagnostic in differentiating various taxa. In addition, a template for the morphology of the proximal end of the first rib has been created to be used for both the general as well as the specific identification of fossilised fragments, and to determine thoracic shape. The recently recovered costal elements of the Australopithecus sediba fossils were also examined as one of the most abundant assemblages of the elements in the early hominin record in order to add to our understanding of the morphology, and evolution of this poorly known area of hominin anatomy. The thorax of Australopithecus sediba demonstrates a medio-laterally narrow, ape-like upper thoracic shape, which is different from the broad upper thorax of Homo that has been associated with to the locomotor pattern of endurance walking and running. The lower thorax, however, is less laterally-flared than that of apes, and more closely approximates the morphology found in humans. This indicates a mosaic morphology of the thorax during the human evolutionary linage.
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22

Benjamin, Monique Michelle. "The effectiveness of thoracic versus cervical spine manipulative therapy in the treatment of chronic neck pain." Thesis, 2012. http://hdl.handle.net/10210/7892.

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M.Tech.
Purpose: Posterior mechanical neck pain is considered a debilitating musculoskeletal problem and is one of the most common reasons for visiting an emergency sector (Murphy, 2000). This study aims to compare the effects of Chiropractic manipulative therapy directed at the thoracic spine to that directed at the cervical spine for the treatment of chronic neck pain with regards to pain, disability and cervical range of motion. Method: This study was a comparative study and consisted of two groups of fifteen. The participants were between the ages of eighteen and forty-five, with a half male to female ratio. The potential participants were examined and accepted according to the inclusion and exclusion criteria. The method of treatment administered to each participant was determined by group allocation. Group 1 received chiropractic spinal manipulative therapy to restriction(s) of the upper thoracic region only. Group 2 received chiropractic spinal manipulative therapy to restriction(s) of the cervical spine only. Objective and subjective findings were based on the above treatment protocols. Procedure: Treatment consisted of six treatment consultations with an additional follow up consultation over a three week period, with two consultations being performed per week interval. Objective and subjective readings were taken at the beginning of the first, fourth and seventh consultations. Subjective readings were taken from the Vernon-Mior Neck Pain and Disability Index as well as from the Numerical Pain Rating Scale (NPRS). Objective readings were taken from measurements taken from the Cervical Range of Motion device (CROM). Analysis of collected data was performed by a statistician. The Chiropractic manipulative techniques used were based on restrictions identified during motion palpation and were applied at the first six consultations, with the seventh consultation consisting of data gathering only. Results: Clinically significant improvements in both Group 1 and Group 2 were seen over the course of the study with regards to cervical spine range of motion, pain and disability. However group 1 showed greater statistically significant improvements in their mean cervical range of motion whereas group 2 showed a greater statistically significant improvement in their subjective readings of pain and disability.
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Else, Jeanette Mary. "The inferior angle of the scapula as a landmark to locate the seventh thoracic spinous process." Thesis, 2012. http://hdl.handle.net/10210/4763.

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M. Tech.
Although Chiropractors rely on palpation as a clinical tool, its reliability still remains to be proven (O‟Haire and Gibbons, 2000). Motion palpation is based on the assumption that Chiropractors‟ and other manual medicine practitioners‟ static palpation is performed correctly to identify bony anatomical landmarks (O‟Haire and Gibbons, 2000). The most common method taught to chiropractic students on the location of the seventh thoracic spinous process, is to place the patient‟s hand in the small of their back, forcing the inferior angle of the scapula to become more prominent. The horizontal line from the inferior angle of the scapula to the vertebral column is said to be on the seventh thoracic spinous process (T7). Therefore the scapula is a widely used anatomical landmark. One would therefore expect the literature to all be in agreement to the position of this line, but according to the literature consulted, it seems to vary. This study aimed to determine whether palpation of the inferior angle of the scapula was a reliable, accurate and/or a valid method of determining the location of the seventh thoracic spinous process. Sixty participants were marked by three examiners in the seated position, using the inferior angle of the scapula to locate the seventh thoracic spinous process. After being marked by all three examiners, measurements were then made on CT scan films as well as visual assessments by examiners to assess the location of the markers on the thoracic anatomy. The results demonstrated substantial inter-examiner reliability, and poor accuracy in locating the seventh thoracic spinous process. This is disappointing as the ability to palpate spinal levels is a basic skill and the cornerstone of Chiropractic assessment.
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24

Edmunds, Brett. "Lower respiratory tract disorders and thoracic spine pain and dysfunction in subjects presenting to the Durban Institute of Technology Chiropractic Day Clinic : a retrospective clinical survey." Thesis, 2003. http://hdl.handle.net/10321/361.

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Thesis (M.Tech.: Chiropractic)-Dept. of Chiropractic, Durban Institute of Technology, 2003. x, 101 leaves
Anecdotal evidence and some developmental theory suggest that lower respiratory tract pathologies may be associated with thoracic spine pain and dysfunction. This hypothetical association may be better described either as respiratory conditions occurring as a result of musculoskeletal dysfunction of the thoracic spine, or as respiratory conditions causing thoracic musculoskeletal dysfunction. Optimal function of the lungs and the process of ventilation is dependant on the normal function of the thoracic spine and the rib cage. Disturbances of the musculoskeletal components of the thoracic spine may lead to increased respiratory efforts, decreased lung function and in turn affect bronchopulmonary function. Obstructive respiratory diseases such as asthma, bronchitis and emphysema place an increased demand on the musculoskeletal components involved in expiration, as air has to be forcefully expired. The purpose of this quantitative, non experimental, demographic retrospective clinical survey was to retrospectively describe lower respiratory tract disorders and thoracic spine pain and dysfunction in subjects presenting to the Durban Institute of Technology Chiropractic Day Clinic, in terms of the prevalence of lower respiratory tract disorders as well as any association between the presenting respiratory conditions and their vertebral distribution in the thoracic spine.
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Myburgh, Hendrik Johannes. "The impact of thoracic spine radiographs in the diagnosis and management of patients who present with thoracic spine pain at the chiropractic day clinic at the Durban University of Technology." Thesis, 2016. http://hdl.handle.net/10321/1723.

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Submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic, Durban University of Technology, Durban, South Africa, 2016.
Background: Thoracic spine pain (TSP) is a very common condition and can be just as disabling as cervical and lumbar pain. The causes of thoracic spine pain are numerous, ranging from less serious non-specific mechanical causes to serious specific underlying pathology. Chiropractors used to request routine radiographs as part of their diagnostic work-up, however limited correlation currently exists between radiographical findings and clinical symptoms in non-specific mechanical thoracic spine pain. The overutilization of plain film radiographs worldwide emphasises the need to investigate which clinical conditions in patients with TSP are sent for radiographs and if they were ethically indicated. Literature is currently limited on the role of thoracic spine x-rays and their influence on the management of patients with TSP. Objectives: The objectives of this retrospective study were: 1) to record the consultation at which thoracic spine radiographs were requested by the student or clinician and the reasons therefore, 2) to determine the number of incidental radiographic findings in the selected patients‟ radiographs, 3) to determine the suspected clinical diagnosis and management of the selected patients prior to referral for thoracic spine radiographs, 4) to determine any change in the clinical diagnoses and management following radiographic reporting of the selected patient‟s radiographs, 5) to determine the correlation between the suspected clinical diagnosis and the radiographic diagnosis of patients with thoracic spine pain. Method: The archives of the Chiropractic Day Clinic (CDC) at the Durban University of Technology (DUT) were searched for all available thoracic spine radiographs and corresponding patient files of patients who presented to the clinic with thoracic spine pain from 1 January 1997 to 31 December 2014. The ABCS (Alignment, Bone, Cartilage, Soft tissue) System was utilised to record data of the radiographs without any knowledge of the patient‟s main compliant. The corresponding patient files were then evaluated with selected clinical variables being recorded. Statistical analysis and interpretation included frequency counts, percentages, mean, standard deviation and ranges for the descriptive objectives. The radiographic and clinical diagnoses were then compared in a two-by-two table to determine any possible relationships in diagnoses of patients with thoracic spine pain. Results: Thirty clinical files and their corresponding thoracic spine radiographs were analysed in this study. The mean age of the patients was 43.6 (± 19.1) years with a gender distribution of 40% males and 60% females. Statistical testing using paired t-tests in order to assess the correlation between the clinical and radiological diagnoses was not possible, as the categories were too different. The most frequent primary radiological diagnosis was both old trauma and scoliosis at 33.3%, followed by thoracic spondylosis at 20%. The majority of thoracic spine radiographs were requested at the initial consultation. The most common reasons for radiographic referral were severe, progressive TSP at 58.6%, trauma at 48.3% and persistent, localised TSP for more than four weeks at 37.9%. The diagnosis remained unchanged in 70% of the patients following radiographic examination. However, in 30% of the cases the clinical diagnosis was changed following radiographic examination. Most patients were diagnosed with non-specific mechanical causes of thoracic spine pain. A wide variety of treatment modalities were utilised before and after radiographic examination, including soft tissue therapy, electro modalities, spinal manipulative therapy and dry needling. A total of 66.6% of the patients in the study had changes made to their management protocol following radiographic evaluation. There was a greater use of spinal manipulative therapy, following radiographic evaluation at 56.7% versus only 26.7% of cases prior to radiographic imaging. Conclusion: Thoracic spine radiographs have little impact on the diagnosis and management of patients with thoracic spine pain as the majority of clinical diagnoses were non- specific mechanical causes of thoracic spine pain. Thoracic spine radiographs were influential in the diagnosis and management of 30% of the cases. Thoracic spine radiographs may therefore be over-utilised at the DUT CDC. However, the use of spinal manipulative therapy more than doubled following radiographic evaluation of the thoracic spine in patients with thoracic spine pain.
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Govender, Derusha. "Racial variations of selected thoracic spine radiographic parameters of males in the greater Durban area." Thesis, 2014. http://hdl.handle.net/10321/1056.

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Submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic, Durban University of Technology, 2014.
Aim: The aim of this study was to evaluate the normal selected radiographic parameters (thoracic kyphosis (TK), anterior vertebral body height (AVBH), posterior vertebral body height (PVBH), intervertebral disc height (IVDH) and interpedicular distance (IPD)) in young to middle-aged males across the four racial groups in Durban. Participants: Eighty young to middle-aged apparently healthy males between the ages of 18-45 years from the White, Black, Indian and Coloured racial groups in Durban. Methodology: After written informed consent was acquired, all participants underwent a case history, physical examination and thoracic orthopaedic examination. An AP and lateral radiograph of the thoracic spine was then obtained. The TK, AVBH, PVBH, IVDH and IPD were assessed using methods described previously. The IBM SPSS version 20 was utilized for the data analysis. Mean, standard deviation (SD) and range are reported for the TK, AVBH, PVBH and IPD for each of the four racial groups. For the IVDH, however, the median for the respective vertebral levels is given. ANOVA testing with Bonferroni post-hoc tests were used to determine overall inter-group variations and compare each group to the other. Pearson’s correlation test was used to determine the relationship between the thoracic kyphosis and the other radiographic parameters that were assessed. Results : The mean, SD, minimum and maximum values of the thoracic kyphosis by racial group There was no significant difference in the TK among the four race groups. Significant differences (p < 0.05) were observed in the AVBH, PVBH, IVDH and IPD between the White, Black, Indian and Coloured males at various thoracic levels. Conclusion: The trends of the various radiographic parameters observed in this study support the argument that these parameters should be based on sex, age and geographic race. These values would be useful for South African spinal health care practitioners in the diagnosis and management of spinal disorders.
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27

Zeyzus, Johns Bree. "TRPV1 mRNA is differentially expressed in different vertebral levels of rat dorsal root ganglia following sciatic nerve injury." 2009. http://digital.library.duq.edu/u?/etd,126912.

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28

Petersen, Gabriela Elisa da Silva. "The effect of thoracic spine manipulation compared to thoracic spine and costovertebral joint manipulation on mechanical mid-back pain at the Durban University of Technology Chiroptractic Day Clinic." Thesis, 2017. http://hdl.handle.net/10321/2894.

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Submitted in fulfillment of the requirements for the Master’s Degree in Technology: Chiropractic, Durban University of Technology, Durban, South Africa, 2017.
Mid-back pain (mbp) is defined as pain occurring within the limits of the third thoracic (T3) and ninth thoracic (T9) vertebrae, caused by the dysfunction of the musculoskeletal structures in the thoracic spine. It can present as pain and/ burning between the shoulder blades with reduced thoracic spine mobility and increased muscle tension. Congenital disorders such as scoliosis and Scheuermann’s disease, or acquired disorders such as thoracic facet and costovertebral joint dysfunction may cause mbp. The thoracic facet and costovertebral joints are similar in anatomy and share a mutually dependent biomechanical relationship. There were a handful of controlled studies that highlighted the effectiveness of thoracic facet manipulation on mbp, but there were none on the effects of costovertebral manipulation on mbp. Objectives The aim of this study was to investigate the immediate effects of the combination of thoracic facet and costovertebral joint manipulation on mbp in terms of pain perception, pressure pain thresholds (PPT) and thoracic spine range of motion (ROM). Design A prospective single-blind randomised comparative clinical trial. Setting This study was conducted in a university setting at the Durban University of Technology Chiropractic Day Clinic Participants Fifty participants were recruited via responses to advertisements placed around the Durban University of Technology (DUT) campuses and individuals presenting at the Chiropractic Day Clinic (CDC). Intervention The participants were divided into two groups of twenty-five. Group A received the thoracic facet joint manipulations and Group B received a combination of the thoracic facet and costovertebral joint manipulations. Outcome measures All subjective and objective measurements were taken before and after the application of the manipulations. Pain perception i.e. subjective measurement) was measured by the Numerical Pain Rating Scale (NPRS), pressure pain thresholds (PPT) (i.e. objective measurement) were measured by the Wagner’s FDK Force Gage Algometer and thoracic spine range of motion (ROM) i.e. objective measurement was measured by the Saunders Digital Inclinometer. Results The data was analyzed using the latest version of SPSS and a p-value = 0.05 was used to determine statistical significance. Descriptive statistics in the form of univariate analysis described the data in terms of measures of central tendency and measures of dispersion. Data that was distributed normally was analyzed using the t-test and ANOVA. Data that was distributed abnormally was analyzed using the non-parametric Wilcoxon ranked and Mann Whitney tests. Nominal and ordinal data was analyzed using the Chi squared test. The results of the intra-group analysis indicated a statistically significant decrease in pain perception (p ≤ 0.000), increase in PPT (p ≤ 0.05) and decrease in thoracic spine ROM (p ≤ 0.000). However, the results for the inter-group analysis indicate there was no statistically significant difference in pain perception (p = 0.386), PPT (p > 0.05) and thoracic spine ROM (p >0.05) between Group A and Group B. Conclusions These results showed that the combination of thoracic facet and costovertebral joint manipulation was as effective as thoracic facet joint manipulation alone, in the treatment of mbp. These findings suggested that manipulation of the costovertebral joints may not be necessary for the effective treatment of mbp.
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Pillay, Amashnee. "The period prevalence of congenital thoracic and lumbar spine anomalies and the association between the literature reported clinical features of these anomalies with the subject's presenting clinical features." Thesis, 2007. http://hdl.handle.net/10321/153.

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Thesis (M.Tech.: Chiropractic)-Dept. of Chiropractic, Durban University of Technology, 2007 xi, 38 leaves, Annexures 1-2
Background: Various congenital spinal anomalies are common findings in the general population. Their clinical significance is controversial with no definitive association been made between any specific congenital spinal anomaly to any clinical features. Project Design: This research study was designed in the form of a quantitative, non-experimental, empirical clinical survey. Method: Data was obtained from thoracic and lumbar spine radiographs contained in the Chiropractic Day Clinic at the Durban University of Technology from 1 January 1997 to 31 December 2005 and from the corresponding patient files. Through the research procedure, 519 thoracic and lumbar spine radiographs were located in the confines of the Chiropractic Day Clinic. Due to the exclusion criteria of a past or present history of trauma to the thoracic or lumbar spine areas, 147 radiographs were excluded. Objectives 1.To determine the period prevalence (1 January 1997 – 31 December 2005) of congenital thoracic and lumbar spine anomalies. 2.To determine if there is any association between the presenting clinical features and the congenital thoracic and lumbar spine anomalies in general. 3.To determine if there is any association between the presenting clinical features and individual congenital thoracic and lumbar spine anomalies. 4.To compare subjects presenting clinical features with reported clinical features from literature.
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30

Matsebula, Lindelwe. "The effectiveness of lower thoracic spinal manipulation on lumbar extensor muscle endurance and range of motion in asymptomatic males : a placebo controlled study." Thesis, 2015. http://hdl.handle.net/10321/1344.

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Submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic, Department of Chiropractic, Durban University of Technology, Durban, South Africa, 2015.
Background: Spinal manipulative therapy (SMT) is a commonly used treatment for many musculoskeletal conditions although the exact mechanism explaining its effectiveness is not well understood. Several studies have investigated the effect of SMT on the paraspinal muscles where neuromuscular effects have been observed, however few studies have assessed whether these changes result in a change in the functioning of the paraspinal muscles. This study aimed to determine the effect of lower thoracic spinal manipulation compared to a placebo intervention on lumbar extensor muscle endurance in asymptomatic participants. Methodology: This was a quantitative, pre-test post-test, placebo controlled trial involving 40 male participants between the ages of 20 and 40 years. The participants were randomly allocated to either the lower thoracic spinal manipulation group or a placebo group. Manipulation was delivered using the Impulse Adjusting Instrument®. Objective measures included lumbar spinal range of motion, a paraspinal muscle endurance test, and surface electromyography readings. Subjective measures were the verbalisation of pain and/or discomfort during the paraspinal muscle endurance test. IBM® SPSS® statistics version 21 and STATA 11 were used to analyse the data. A p-value of <0.05 was considered statistically significant. Results: There were no statistically significant differences between the groups in terms of subjective and objective measurements. A trend of treatment effect was observed for paraspinal muscle endurance where the intervention group showed noticeable improvements in endurance scores. Conclusion: Further studies need to be conducted to determine if the trends observed would occur in a larger study population.
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31

Lin, Yi-Fen, and 林怡棻. "Function of the Heterotopic Bone on the Second Thoracic Vertebra in Shrews." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/56279431212986962962.

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碩士
國立臺灣大學
生態學與演化生物學研究所
97
Heterotopic bones are bones that are dissociated from the rest of the body skeleton in vertebrates. Through the examination of double stained specimens of seven of the eight shrew species in Taiwan, a needle-shaped heterotopic bone was found over the second thoracic vertebra(T2)in three Crocidura spp. and Suncus murinus, but not in Episoriculus fumidus, Chodsigoa sodalis or Anourosorex yamashinai. In this study, I used C. tanakae and C. shantungensis who have T2 heterotopic bone and Episoriculus fumidus who lacks the bone as subjects and conducted myological analysis, behavioral observation, head and body structure analysis, and statics analysis for muscle force affected by T2 heterotopic bone, in order to understand the functions of this bone in shrews. My results revealed that the splenius muscle is the major muscle that originates from the T2 heterotopic bone and inserts to the lateral half of the lambdoidal ridge of skull. The center of gravity of skulls of Crocidura spp. was farther away from occipital region than that of E. fumidus and was farther away from T2 fulcrum than that of E. fumidus in “Head Stretch Forward” and “Head Search” movements. Benefiting from the mechanical advantage enhanced by the T2 heterotopic bone for splenius muscle, Crocidura spp. can perform higher frequency of movements associated with the head. They can also stretch more of their cervical and thoracic vertebra in these movements than E. fumidus.
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32

Jen-Pei, Sun. "The Study of Vertebral Heart Scale in Right Lateral Recumbent Thoracic Radiographs in Small Breed Dogs." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2307200622021000.

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33

Sun, Jen-Pei, and 孫禎珮. "The Study of Vertebral Heart Scale in Right Lateral Recumbent Thoracic Radiographs in Small Breed Dogs." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/02333494587014283815.

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碩士
國立臺灣大學
獸醫學研究所
94
Objective measurement of radiographic cardiac size, such as the vertebral heart scale (VHS) method, has become one of the most common methods to evaluate the canine and feline cardiac size in radiographs due to its simplicity and limited inter-observer variation which can overcome the limitations of previous reported measuring methods. One hundred and two small breed dogs without cardiac diseases joined in the first study to determine the effects of sex, age, body weight and breed on the VHS in small breed dogs. The results presented that age and sex did not affect the radiographic cardiac size in small breed dogs free from cardiac diseases, and the body weight was positively correlated to the VHS value; the mean VHS value of Pomeranian was significantly different from other four popular breeds in the first study. In the second study, VHS was measured in right recumbent lateral thoracic radiographs of 275 small breed dogs to investigate the relationship between VHS and the modified New York heart association functional classification in small breed dogs. The results suggested that severity of heart failure was positively correlated with the VHS revealed by the lateral thoracic radiographs in small breed dogs, and the development of heart failure compensatory mechanisms should be linked together with the heart failure severity and the radiographic cardiac size to evaluate the cardiac condition of dogs more accurately.
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34

Sani, Hassan Yauri. "The morphometric description of the thoracic and lumbar vertebral pedicles in European, African and mixed population of South Africa." Thesis, 2018. https://hdl.handle.net/10539/25258.

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A Dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Medicine, 2018
The use of pedicle screws fixation for surgical management of spinal disorders has become increasingly popular worldwide. Segmental pedicle screw fixations are used in spinal canal decompression surgery for various spine disorders such as scoliosis, spondylolisthesis, fractures, tumor and iatrogenic or degenerative instability. The main challenge to the use of pedicle screw can be due to mismatched size of the screw and the pedicle. This may result in cortical perforation of the pedicle or fracture of the pedicle. Understanding of pedicle morphometric values is important in designing pedicle screw systems as well as in accurately placing the screws to avoid or minimize complications. Most of the studies on the morphometry of the vertebral pedicles have been reported in the European populations, with a few reports in Asian populations and none in the African populations. Previous studies have shown significant population and ethnic differences in pedicle morphometry. The current study presents information on the thoracic and lumbar pedicle dimensions at the isthmus in the European, African and Mixed-ancestry populations of South Africa. The study utilized thoracic and lumbar vertebrae of 60 African, 60 European and 54 Mixed ancestry adult human populations of South Africa with equal male to female representation. The dry human skeletons used were obtained from the Raymond A. Dart Collection of Human specimens housed in the School of Anatomical Sciences at the University of the Witwatersrand. Pedicles of the vertebrae were assessed and measured. The external measurements on the isthmus of the pedicle were performed using a digital Vernier caliper (accuracy, 0.1 mm) on the right and left pedicles. The angular measurements were performed with a standard goniometer (accuracy of 1°). The measurements taken at the isthmus of the vertebral pedicle included the pedicle width, pedicle height, transverse angle, sagittal angle, chord length and inter-pedicular distance. For the internal measurement, all the vertebrae were radiograph and the transverse (width) and vertical (height) inner cortical diameters were measured at the isthmus of the pedicle using image processing software (image J®). In the three populations of South Africa, the mean pedicle width was found to gradually decrease from vertebral levels T1 to T5 and then gradually increased to vertebral level T12 in the thoracic spine whereas in the lumbar spine, the mean pedicle width gradually increased from vertebral levels L1 to L5. The mean pedicle height gradually increased from T1 to T12 in the thoracic spine and in the lumbar spine it gradually decreased from L1 to L5. The mean transverse angle gradually decreases from vertebral levels T1 to T8 and then increased gradually to vertebral level T12 in the thoracic spine, and in the lumbar spine, it increased gradually from vertebral levels L1 to L5. The mean sagittal angle marginally decreased from vertebral levels T1 to T7 and then increased to vertebral level T12 in the thoracic spine, and in the lumbar spine it slightly increased from vertebral levels L1 to L5. The mean chord length gradually increased from vertebral levels T1 to T12 in the thoracic spine, while in the lumbar spine it gradually increased from vertebral levels L1 to L3 and then slightly decreased from level L4 to L5. The mean inter-pedicular distance was found to gradually decrease from vertebral levels T1 to T6 then gradually increased to vertebral level T12 in the thoracic spine, and in the lumbar spine, the mean inter-pedicular distance gradually increased from vertebral levels L1 to L5. The mean transverse inner cortical diameter gradually decreased from vertebral levels T1 to T5 and then gradually increased to vertebral level T12 in thoracic spine, and in the lumbar spine; it gradually increased from vertebral levels L1 to L5. The mean vertical inner cortical diameter gradually increase from vertebral levels T1 to T12 in the thoracic spine whereas in the lumbar spine it gradually decrease from L1 to L5.
XL2018
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35

Kittel, Heiner Peter. "A study to determine the efficiency of upper cervical vertebral manipulation as opposed to a combination of upper cervical and upper thoracic vertebral manipulation in the treatment of migraine without aura." Thesis, 2014. http://hdl.handle.net/10210/11759.

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M.Tech. (Chiropractic)
The object of this study was to compare two chiropractic treatment approaches to each other in the management of migraine without aura. It was hypothesised that a combination of upper cervical and upper thoracic chiropractic manipulative therapy would be more effective than upper cervical chiropractic manipulative therapy alone. Migraine without aura was diagnosed according to the criteria of the International Headache Society (1988) and based on a structured case history, physical examination as well as regional orthopaedic and neurological examinations. Forty-one (41) subjects were randomly allocated to one of the two treatment groups in this single blind, randomised trial. Thirty-three patients completed the trial. Both groups received their respective chiropractic manipulative treatments twice a week for a total period of four weeks. During this time and a period of eight weeks thereafter, each patient kept a daily headache diary, noting migraine frequency, duration, headache intensity and associated analgesic pill consumption. Statistical analysis of the collected data involved inter-group comparisons of the above mentioned variables using Mann-Whitney Rank Sum tests, and intra-group comparisons of the above. mentioned variables using Wilcoxon Signed Rank tests at a 95% level of confidence. Intra-group analysis of the data revealed statistically significant (P < 0.05) decreases in migraine frequency and headache intensity for both groups. Migraine duration followed a similar pattern but for a sudden increase in duration in the third month for the group receiving a combination of upper cervical and upper thoracic chiropractic manipulative therapy. Inter-group analysis of the data established no statistically significant differences (P > 0.05) between the two treatment groups before or during the study. Throughout the study, there was a notable difference in average analgesic pill consumption between the two groups. The results indicate that both chiropractic manipulative therapy approaches had positive effects on the frequency, duration and headache intensity of migraines without aura. The effect of chiropractic manipulative therapy on the associated analgesic pill consumption is speculative, since there was no pre-treatment assessment of analgesic pill consumption. The sudden increase in migraine duration during the third month for the group that received both upper cervical and upper thoracic manipulation may be due to this treatment being less effective than upper cervical manipulation alone. The significance of this sudden increase will need to be established by future studies. Neither one of the two chiropractic treatment protocols applied in this study fared significantly better than the other. It is suggested that future studies consider any disability associated with migraines without aura. A pre-treatment trial period would provide reliable pre-treatment statistics for the variables investigated during such a trial and larger samples would represent the overall migraineur population better. It is suggested that a third group, receiving only chiropractic manipulative therapy to the upper thoracic spine, also be included.
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36

Pereira, Natália Luísa Vasconcelos. "Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury." Master's thesis, 2016. http://hdl.handle.net/1822/46964.

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Dissertação de mestrado Ciências da Saúde
Damage to the spinal cord can result in irreversible impairments and complete loss of motor, sensory and autonomic functions. Riluzole and magnesium have been widely investigated as neuroprotective agents in animal models of spinal cord injury. As these drugs protect the injured spinal cord through different mechanisms we aimed to investigate if their neuroprotective efficacy could be cumulative. An in vivo experiment was set using female Wistar Han rats that underwent a thoracic spinal cord contusion (T8) using a weight drop method. An hour after injury, animals were randomly distributed to receive: 1) saline, 2) riluzole (2.50 mg/kg), 3) magnesium chloride (24.18 mg/kg) in a polyethylene glycol formulation, or 4) a combined treatment (riluzole and magnesium). Subsequent treatments were given in four intraperitoneal injections (spaced 12 h apart). The Basso, Beattie, and Bresnahan locomotor rating scale, an activity box test, and a swimming test were used to evaluate behavioral recovery for periods up to four weeks. Histological analysis of the spinal cords was performed to measure the extent and volume of the lesion, axonal preservation, serotonergic and glutamatergic fiber sparing, motor neuron survival, and inflammation. The results demonstrated that only the riluzole treatment significantly improved behavioral recovery, promoted tissue sparing, reduced lesion volume, while increasing serotonergic fiber sparing and axonal preservation in the caudal portion of the spinal cord. The combined treatment, although simultaneously targeting ionic and excitotoxic-related mechanisms, did not further improve behavioral and histological outcome, when compared with riluzole given alone.
Danos infligidos na medula espinal podem resultar em deficiências irreversíveis e perda total de funções motoras, sensoriais e autonómicas. Os fármacos riluzole e magnésio têm sido amplamente investigados como agentes neuroprotetores em modelos animais de lesão vertebro-medular. Dado que estes fármacos protegem a medula lesionada através de mecanismos diferentes, um estudo foi desenvolvido com o objetivo de determinar se a sua eficácia neuroprotetora poderia ser cumulativa. Um ensaio in vivo foi definido utilizando ratos fêmeas Wistar Han submetidos a uma contusão torácica da medula espinal (T8). Uma hora após a lesão, os animais foram distribuídos aleatoriamente para receber: 1) solução salina, 2) riluzole (2,50 mg / kg), 3) cloreto de magnésio (24,18 mg / kg) numa formulação de polietilenoglicol, ou 4) um tratamento combinado (riluzole e magnésio). Os tratamentos subsequentes foram dados em quatro injeções intraperitoneais (com espaçamento de 12 horas). Foram utilizados a escala de classificação locomotora Basso, Beattie e Bresnahan, um teste de campo aberto (open-field) e um teste de natação, para avaliar a recuperação comportamental/motora dos animais durante um período de quatro semanas. Foi também realizada uma análise histológica das medulas espinais de forma a medir a extensão do volume da lesão, preservação das fibras axonais, serotonérgicas e glutamatérgicas, sobrevivência de neurónios motores e inflamação. Os resultados mostraram que apenas o tratamento com riluzole melhorou significativamente a recuperação funcional, preservou tecidos e concomitantemente obteve volumes de lesão reduzidos, assim como aumentou a preservação das fibras serotonérgicas e axonais na parte caudal da medula espinal. O tratamento combinado, embora visando simultaneamente dois mecanismos relacionados com desequilíbrios iónicos e excitotoxicidade, não resultou em melhorias funcionais e histológicas, quando comparado com a administração isolada de riluzole.
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37

Parker, Christopher Daniel. "The development of a posterior dynamic stabilisation implant indicated for thoraco-lumbar disc degeneration / Christopher Daniel (Chris) Parker." Thesis, 2013. http://hdl.handle.net/10394/12254.

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Posterior lumbar spinal dynamic stabilisation devices are intended to relieve the pain of spinal segments while prolonging the lifespan of adjacent intervertebral discs. This study focuses on the design of such a device, one that has the correct stiffness to stabilise the spinal segment by the correct amount. An initial literature survey covers contemporary topics related to the lumbar spine. Included topics are lumbar anatomy and kinematics, pathology of degenerative disc disease and treatment thereof, other spinal disorders such as spondylolisthesis and spinal stenosis, as well as the complications associated with lumbar dynamic stabilisation. The influence of factors such as fatigue and wear, as well as the properties of appropriate biomaterials are considered when determining the basis of the device design and development. Stabilising the spinal segment begins with correct material selection and design. Various designs and biomaterials are evaluated for their stiffness values and other user requirements. The simplest design, a U-shaped spring composed of carbon fibre-reinforced poly-ether-ether-ketone (CFR-PEEK) and anchored by polyaxial titanium pedicle screws, satisfies the most critical user requirements. Acceptable stiffness is achieved, fatigue life of the material is excellent and the device is very imaging-friendly. Due to financial constraints, however, a simpler concept that is cheaper and easier to rapid prototype was chosen. This concept involves a construct primarily manufactured from the titanium alloy Ti6Al4V extra-low interstitial (ELI) and cobalt-chrome-molybdenum (CCM) alloys. The first rapid prototype was manufactured using an additive manufacturing process (3D-printing). The development of the device was performed in three main stages: design, verification and validation. The main goal of the design was to achieve an acceptable stiffness to limit the spinal segmental range of motion (ROM) by a determined amount. The device stiffness was verified through simple calculations. The first prototype’s stiffness was validated in force-displacement tests. Further validation, beyond the scope of this study, will include fatigue tests to validate the fatigue life of the production-ready device.
MIng (Mechanical Engineering), North-West University, Potchefstroom Campus, 2014
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