Academic literature on the topic 'Thiol binding'
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Journal articles on the topic "Thiol binding"
Lee, Duk-Shin, and Ji-Eun Kim. "PDI-Mediated Reduction of Disulfide Bond on PSD95 Increases Spontaneous Seizure Activity by Regulating NR2A–PSD95 Interaction in Epileptic Rats Independent of S-Nitrosylation." International Journal of Molecular Sciences 21, no. 6 (March 18, 2020): 2094. http://dx.doi.org/10.3390/ijms21062094.
Full textQUINLAN, Gregory J., Michael P. MARGARSON, Sharon MUMBY, Timothy W. EVANS, and John M. C. GUTTERIDGE. "Administration of albumin to patients with sepsis syndrome: a possible beneficial role in plasma thiol repletion." Clinical Science 95, no. 4 (October 1, 1998): 459–65. http://dx.doi.org/10.1042/cs0950459.
Full textChoi, Hiuwan, Khatira Aboulfatova, Henry J. Pownall, Richard Cook, and Jing-fei Dong. "Shear-induced Disulfide Bond Formation Regulates Adhesion Activity of von Willebrand Factor." Journal of Biological Chemistry 282, no. 49 (October 9, 2007): 35604–11. http://dx.doi.org/10.1074/jbc.m704047200.
Full textLahav, Judith, Kerstin Jurk, Oded Hess, Michael J. Barnes, Richard W. Farndale, Jacob Luboshitz, and Beate E. Kehrel. "Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange." Blood 100, no. 7 (October 1, 2002): 2472–78. http://dx.doi.org/10.1182/blood-2001-12-0339.
Full textRamasamy, Somasundaram, Tapan K. Kundu, William Antholine, Periakaruppan T. Manoharan, and Joseph M. Rifkind. "Internal spin trapping of thiyl radical during the complexation and reduction of cobalamin with glutathione and dithiothrietol." Journal of Porphyrins and Phthalocyanines 16, no. 01 (January 2012): 25–38. http://dx.doi.org/10.1142/s1088424611004051.
Full textJones, Dean P. "Radical-free biology of oxidative stress." American Journal of Physiology-Cell Physiology 295, no. 4 (October 2008): C849—C868. http://dx.doi.org/10.1152/ajpcell.00283.2008.
Full textArican, Sule, Gulcin Hacibeyoglu, Sinan Oguzhan Ulukaya, Gamze Avcioglu, Ruhiye Reisli, Sema Tuncer Uzun, and Ozcan Erel. "Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia." Journal of Laboratory Medicine 43, no. 5 (October 25, 2019): 257–63. http://dx.doi.org/10.1515/labmed-2018-0211.
Full textTong, Ka-Chung, Chun-Nam Lok, Pui-Ki Wan, Di Hu, Yi Man Eva Fung, Xiao-Yong Chang, Song Huang, Haibo Jiang, and Chi-Ming Che. "An anticancer gold(III)-activated porphyrin scaffold that covalently modifies protein cysteine thiols." Proceedings of the National Academy of Sciences 117, no. 3 (January 2, 2020): 1321–29. http://dx.doi.org/10.1073/pnas.1915202117.
Full textSokoloff, A. V., T. Whalley, and J. Zimmerberg. "Characterization of N-ethylmaleimide-sensitive thiol groups required for the GTP-dependent fusion of endoplasmic reticulum membranes." Biochemical Journal 312, no. 1 (November 15, 1995): 23–30. http://dx.doi.org/10.1042/bj3120023.
Full textWhite, Kylie, Gina Nicoletti, and Hugh Cornell. "Antibacterial Profile of a Microbicidal Agent Targeting Tyrosine Phosphatases and Redox Thiols, Novel Drug Targets." Antibiotics 10, no. 11 (October 27, 2021): 1310. http://dx.doi.org/10.3390/antibiotics10111310.
Full textDissertations / Theses on the topic "Thiol binding"
Tong, Grace C. "Characterization of Cys-34 in serum albumin." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5fnum=osu1061473878.
Full textTitle from first page of PDF file. Document formatted into pages; contains xxiii, 325 p.; also contains graphics (some col.). Includes abstract and vita. Advisor: Gary E. Means, Dept. of Biochemistry. Includes bibliographical references (p. 206-225).
Rossato, Mateus Fortes. "Eriodictiol: um flavonóide antagonista do receptor trpv1 com atividade antioxidante." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/11134.
Full textThe transient receptor potential vanilloid 1 (TRPV1) is a calcium permeable channel responsible for the transduction and modulation of acute and chronic pain signaling, being a potential target for treatment of different pain disorders. In spite of that, AMG517, a TRPV1 antagonist, presents several clinical limitations, such as the development of severe hypertermia. The aim of this study was to investigate the possible interaction of the flavonoid eriodictyol with the TRPV1 receptor and its putative antinociceptive and hyperthermic effect. Eriodictyol was able to displace the [3H]-resiniferatoxin binding (IC50 = 47 (21 - 119) nM) and to inhibit the calcium influx mediated by capsaicin (IC50 = 44 (16 125) nM), suggesting that eriodictyol acts as a TRPV1 antagonist. Moreover, eriodictyol induces antinociception in the intraplantar capsaicin test, with maximal effect of 49±10 and 64±4% of inhibition for oral (ED50 = 2 (1-5) mg/kg) and intrathecal (ED50 = 2 (1-3) nmol/site) routes, respectively. Concomitantly, eriodictyol did not induce any alteration on body temperature or locomotor activity. Orally administered eriodictyol (4.5 mg/kg) prevented the nociception induced by intrathecal injection of capsaicin (72±6% of inhibition), the non-protein thiol loss and the 3-nitrotyronise (3-NT) formation induced by capsaicin in spinal cord. Eriodictyol (4.5 mg/kg, p.o.) also reduced the thermal hyperalgesia (100% of inhibition) and mechanical allodynia (62±9% of inhibition) elicited by complete Freund s adjuvant (CFA) paw injection. In conclusion, Eriodictyol acts as an antagonist of TRPV1 receptor and an antioxidant, inducing antinociception without some side effects and limitations expected for TRPV1 antagonists, as hyperthermia.
O receptor de potencial transiente vanilóide 1 (TRPV1) é um canal iônico permeável a cátions ativado por uma série de estímulos nocivos, como calor, acidificação e agentes irritantes como a capsaicina. Este receptor é responsável pela detecção e transmissão da dor aguda e crônica. Devido a isso, substâncias que modulem a atividade deste receptor apresentam um potencial clínico para o tratamento da dor. Assim, este trabalho objetiva a possível interação do flavonóide eriodictiol com o receptor TRPV1. Inicialmente, observamos que o eriodictiol foi capaz de deslocar o radioligante [3H]-resiniferatoxina, em ensaio de união específica, do receptor TRPV1 com uma concentração inibitória 50% (IC50) de 46.9 (20.70 - 118.9) nM. Ao mesmo tempo, o eriodictiol também inibiu o influxo de cálcio estimulado por capsaicina com IC50 de 44,4 (15,6 125,1) nM, sugerindo que este aja como um antagonista do receptor. Além disso, também observamos que o eriodictiol induz antinocicepção no teste da capsaicina intraplantar com efeito máximo de 49,0±10.5 e 63,9±4.0 % de inibição máxima para o tratamento oral e intratecal, respectivamente, e com uma dose efetiva 50% (DE50) de 2,4 (1,0 5,5) mg/kg 2,2 (1,6 2,9) nmol/site, respectivamente. Além disso, não observamos alterações na atividade locomotora ou temperatura corporal dos animais. A administração oral de eriodictiol também foi capaz de prevenir a nocicepção induzida por capsaicina intratecal (71,7±5,7 % de inibição). Ao mesmo tempo, o eriodictiol também aboliu a hiperalgesia térmica e reduziu a alodínia mecânica (62,4±9,2 %) induzidas por adjuvante completo de Freund. Da mesma forma, o eriodictiol também preveniu totalmente a diminuição de tiois não protéicos e formação de 3-nitrotirosina (3-NT) espinhais induzidas por capsaicina, ao passo que apresentou atividade antioxidante direta no texto de neutralização do radical ABTS. Em conclusão, nossos resultados mostram que o eriodictiol age como um antagonista do receptor TRPV1, com atividade antioxidante, induzindo antinocicepção sem os efeitos colaterais e limitações esperados para antagonistas do receptor TRPV1.
Cafe, Peter F. "Towards reliable contacts of molecular electronic devices to gold electrodes." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3870.
Full textCafe, Peter F. "Towards reliable contacts of molecular electronic devices to gold electrodes." University of Sydney, 2008. http://hdl.handle.net/2123/3870.
Full textSYNOPSIS OF THIS THESIS The aim of this thesis is to more fully understand and explain the binding mechanism of organic molecules to the Au(111) surface and to explore the conduction of such molecules. It consists of five discreet chapters connected to each other by the central theme of “The Single Molecule Device: Conductance and Binding”. There is a deliberate concentration on azine linkers, in particular those with a 1,10-phenanthroline-type bidentate configuration at each end. This linker unit is called a “molecular alligator clip” and is investigated as an alternative to the thiol linker unit more commonly used. Chapter 1 places the work in the broad context of Molecular Electronics and establishes the need for this research. In Chapter 2 the multiple break-junction technique (using a Scanning Tunnelling Microscope or similar device) was used to investigate the conductance of various molecules with azine linkers. A major finding of those experiments is that solvent interactions are a key factor in the conductance signal of particular molecules. Some solvents interfere with the molecule’s interaction with and attachment to the gold electrodes. One indicator of the degree of this interference is the extent of the enhancement or otherwise of the gold quantized conduction peak at 1.0 G0. Below 1.0 G0 a broad range for which the molecule enhances conduction indicates that solvent interactions contribute to a variety of structures which could bridge the electrodes, each with their own specific conductance value. The use of histograms with a Log10 scale for conductance proved useful for observing broad range features. vi Another factor which affects the conductance signal is the geometric alignment of the molecule (or the molecule-solvent structure) to the gold electrode, and the molecular alignment is explored in Chapters 3 for 1,10-phenanthroline (PHEN) and Chapter 4 for thiols. In Chapter 3 STM images, electrochemistry, and Density Functional Theory (DFT) are used to determine 1,10-phenanthroline (PHEN) structures on the Au(111) surface. It is established that PHEN binds in two modes, a physisorbed state and a chemisorbed state. The chemisorbed state is more stable and involves the extraction of gold from the bulk to form adatom-PHEN entities which are highly mobile on the gold surface. Surface pitting is viewed as evidential of the formation of the adatom-molecule entities. DFT calculations in this chapter were performed by Ante Bilic and Jeffery Reimers. The conclusions to Chapter 3 implicate the adatom as a binding mode of thiols to gold and this is explored in Chapter 4 by a timely review of nascent research in the field. The adatom motif is identified as the major binding structure for thiol terminated molecules to gold, using the explanation of surface pitting in Chapter 3 as major evidence and substantiated by emergent literature, both experimental and theoretical. Furthermore, the effect of this binding mode on conductance is explored and structures relevant to the break-junction experiment of Chapter 2 are identified and their conductance values compared. Finally, as a result of researching extensive reports of molecular conductance values, and having attempted the same, a simple method for predicting the conductance of single molecules is presented based upon the tunneling conductance formula.
Bernhard, Max [Verfasser], Gerhard [Akademischer Betreuer] Thiel, and Bodo [Akademischer Betreuer] Laube. "Binding Proteins and Receptor Binding Domains as Sensor Elements for Biological and Artificial Nanopores / Max Bernhard ; Gerhard Thiel, Bodo Laube." Darmstadt : Universitäts- und Landesbibliothek, 2021. http://d-nb.info/1236344782/34.
Full textStröh, Luisa Johanna [Verfasser], and Thilo [Akademischer Betreuer] Stehle. "Structural Analysis and Glycan Receptor Binding Specificities of Human Polyomaviruses / Luisa Johanna Ströh ; Betreuer: Thilo Stehle." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/119946306X/34.
Full textSchönrock, Michael [Verfasser], Bodo [Akademischer Betreuer] Laube, and Gerhard [Akademischer Betreuer] Thiel. "Modular design of ionotropic glutamate receptors: Coupling of a viral K+-channel with a glutamate-binding domain / Michael Schönrock ; Bodo Laube, Gerhard Thiel." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2019. http://d-nb.info/1182537499/34.
Full textYang, Chao. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28942.
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Hetzke, Thilo [Verfasser], Thomas [Akademischer Betreuer] Prisner, Thomas [Gutachter] Prisner, and Josef [Gutachter] Wachtveitl. "PELDOR and hyperfine spectroscopy as complementary tools to investigate a tetracycline-binding RNA aptamer / Thilo Hetzke ; Gutachter: Thomas Prisner, Josef Wachtveitl ; Betreuer: Thomas Prisner." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/1212930312/34.
Full textLiu, Changhui. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Taxol Analogs." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/11186.
Full textPh. D.
Books on the topic "Thiol binding"
Schultz, Caroline Luise. The role of sulphur and thiol-rich copper-binding protein in the copper tolerance of "Deschampsia cespitosa"(L.) Beauv. 1986.
Find full textBook chapters on the topic "Thiol binding"
Ganesan, A. "Romidepsin and the Zinc-Binding Thiol Family of Natural Product HDAC Inhibitors." In Successful Drug Discovery, 13–29. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527800315.ch2.
Full textOkada, Yoshio, Satoshi Tsuboi, Naoki Teno, Hiroshi Okamoto, Atsushi Yamamoto, and Toshimasa Ishida. "Development of reversible inhibitors against thiol proteinases and studies on the binding mode of the inhibitor with papain." In Peptide Chemistry 1992, 499–502. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_145.
Full textInouhe, Mashiro, Huagang Huang, Sanjay Kumar Chaudhary, and Dharmendra Kumar Gupta. "Heavy Metal Bindings and Their Interactions with Thiol Peptides and Other Biological Ligands in Plant Cells." In Metal Toxicity in Plants: Perception, Signaling and Remediation, 1–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22081-4_1.
Full textOdagaki, Yuji. "Guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) Binding/Immunoprecipitation Assay Using Magnetic Beads Coated with Anti-Gα Antibody in Mammalian Brain Membranes." In Co-Immunoprecipitation Methods for Brain Tissue, 97–107. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8985-0_8.
Full textBourdon, Allen K., Greg Villareal, George Perry, and Clyde F. Phelix. "Alzheimer's and Parkinson's Disease Novel Therapeutic Target." In Research Anthology on Diagnosing and Treating Neurocognitive Disorders, 411–26. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-3441-0.ch021.
Full textRagsdale, Stephen W., Nirupama Gupta, Ireena Bagai, Andrea Morris Spencer, and Eric Carter. "Thiol/Disulfide Redox Switches as a Regulatory Mechanism in Heme-binding Proteins." In Handbook of Porphyrin Science, 31–54. World Scientific Publishing Company, 2013. http://dx.doi.org/10.1142/9789814407755_0038.
Full textYoshihara, Eiji, Zhe Chen, Yoshiyuki Matsuo, Hiroshi Masutani, and Junji Yodoi. "Thiol Redox Transitions by Thioredoxin and Thioredoxin-Binding Protein-2 in Cell Signaling." In Methods in Enzymology, 67–82. Elsevier, 2010. http://dx.doi.org/10.1016/s0076-6879(10)74005-2.
Full textDolores Avila-Quezada, Graciela, and Gerardo Pavel Espino-Solis. "Silver Nanoparticles Offer Effective Control of Pathogenic Bacteria in a Wide Range of Food Products." In Pathogenic Bacteria. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89403.
Full textMaret, Wolfgang. "[22] Optical methods for measuring zinc binding and release, zinc coordination environments in zinc finger proteins, and redox sensitivity and activity of zinc-bound thiols." In Protein Sensors and Reactive Oxygen Species - Part B: Thiol Enzymes and Proteins, 230–37. Elsevier, 2002. http://dx.doi.org/10.1016/s0076-6879(02)48641-7.
Full textGaslain, Fabrice, Cyril Delacôte, Bénédicte Lebeau, Claire Marichal, Joël Patarin, and Alain Walcarius. "Study of mercury(II) binding to thiol-modified ordered mesoporous silicas by analytical and electrochemical analyses: influence of the pore structure and the functionalization process." In Recent Progress in Mesostructured Materials - Proceedings of the 5th International Mesostructured Materials Symposium (IMMS2006), Shanghai, P.R. China, August 5-7, 2006, 417–20. Elsevier, 2007. http://dx.doi.org/10.1016/s0167-2991(07)80349-1.
Full textConference papers on the topic "Thiol binding"
Osmani, Bekim, Tino Töpper, and Bert Müller. "Highly compliant nanometer-thin Au electrodes exploiting the binding to thiol-functionalized polydimethylsiloxane films." In Electroactive Polymer Actuators and Devices (EAPAD) XX, edited by Yoseph Bar-Cohen. SPIE, 2018. http://dx.doi.org/10.1117/12.2317867.
Full textYao, Da-Jen, Chun-Yi Lin, and Fangang Tseng. "The application of Iron Oxide magnetic nanoparticles to improve the binding efficiency of the IgG and Thiol SAMs." In 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2007. http://dx.doi.org/10.1109/nems.2007.352255.
Full textKhanna, K., W. Raymond, J. Jin, A. R. Charbit, I. Gitlin, M. Tang, A. D. Werts, et al. "Thiol Drugs Decrease SARS-CoV-2 Lung Injury In Vivoand Disrupt SARS-CoV-2 Spike Complex Binding to ACE-2In Vitro." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3546.
Full textKoneti Rao, A., and Maria A. Kowalska. "ADP-INDUCED CYTOPLASMIC CALCIUM MOBILIZATION AND SHAPE CHANGE IN PLATELETS ARE MEDIATED BY DIFFERENT BINDING SITES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644466.
Full textLim, Si-Hyung “Shawn”, Digvijay Raorane, Srinath Satyanarayana, and Arunava Majumdar. "Nano-Chemo-Mechanical Sensor Array Platform for High Throughput Selective Coating Material Search." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-82151.
Full textColman, R. W., A. Gewirtz, D. L. Wang, M. M. Huh, B. P. Schick, P. K. Schick, and C. L. Shapiro. "BIOSYNTHESIS AND EXPRESSION OF FACTOR V IN MAGAKARYOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642955.
Full textReports on the topic "Thiol binding"
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory. Organisation for Economic Co-Operation and Development (OECD), December 2022. http://dx.doi.org/10.1787/4df0e9e4-en.
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