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Academic literature on the topic 'Thimet'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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Journal articles on the topic "Thimet"

1

Dando, P. M., M. A. Brown, and A. J. Barrett. "Human thimet oligopeptidase." Biochemical Journal 294, no. 2 (September 1, 1993): 451–57. http://dx.doi.org/10.1042/bj2940451.

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We have purified human thimet oligopeptidase to homogeneity from erythrocytes, and compared it with the enzyme from rat testis and chicken liver. An antiserum raised against rat thimet oligopeptidase also recognized the human and chicken enzymes, suggesting that the structure of the enzyme has been strongly conserved in evolution. Consistent with this, the properties of the human enzyme were very similar to those for the other species. Thus human thimet oligopeptidase also is a thiol-dependent metallo-oligopeptidase with M(r) about 75,000. Specificity for cleavage of a number of peptides was indistinguishable from that of the rat enzyme, but Ki values for the four potent reversible inhibitors tested were lower. In discussing the results, we consider the determinants of the complex substrate specificity of thimet oligopeptidase. We question whether substrates containing more than 17 amino acid residues are cleaved, as has been suggested. We also point out that the favourable location of a proline residue and a free C-terminus in the substrate may be as important as the hydrophobic residues in the P2, P1 and P3′ positions that have been emphasized in the past.

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McKie, N., P. M. Dando, N. D. Rawlings, and A. J. Barrett. "Thimet oligopeptidase: similarity to ‘soluble angiotensin II-binding protein’ and some corrections to the published amino acid sequence of the rat testis enzyme." Biochemical Journal 295, no. 1 (October 1, 1993): 57–60. http://dx.doi.org/10.1042/bj2950057.

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The deduced amino acid sequence of pig liver soluble angiotensin II-binding protein [Sugiura, Hagiwara and Hirose (1992) J. Biol. Chem. 267, 18067-18072] is similar over most of its length to that reported for rat testis thimet oligopeptidase (EC 3.4.24.15) by Pierotti, Dong, Glucksman, Orlowski and Roberts [(1990) (Biochemistry 29, 10323-10329]. We have found that homogeneous rat testis thimet oligopeptidase binds angiotensin II with the same distinctive characteristics as the pig liver protein. Analysis of the nucleotide sequences reported for the two proteins pointed to the likelihood that sequencing errors had caused two segments of the amino acid sequence of the rat protein to be translated out of frame, and re-sequencing of selected parts of the clone (kindly provided by the previous authors) confirmed this. The revised deduced amino acid sequence of rat thimet oligopeptidase contains 687 residues, representing a protein of 78,308 Da, and is more closely related to those of the pig liver protein and other known homologues of thimet oligopeptidase than that described previously.

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Knight, C. G., P. M. Dando, and A. J. Barrett. "Thimet oligopeptidase specificity: evidence of preferential cleavage near the C-terminus and product inhibition from kinetic analysis of peptide hydrolysis." Biochemical Journal 308, no. 1 (May 15, 1995): 145–50. http://dx.doi.org/10.1042/bj3080145.

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The substrate-size specificity of human thimet oligopeptidase (EC 3.4.24.15) was investigated with oligomers of glycyl-prolyl-leucine (GPL)n where n = 2, 3, 4 and 5. These peptides were cleaved only at Leu-Gly bonds to give GPL as the single final product. Hydrolysis was most rapid with (GPL)3 and slowest with (GPL)5. The more water-soluble oligomers of Gly-Hyp-Leu showed the same trend. (Gly-Hyp-Leu)6 was not hydrolysed, consistent with the previous finding that substrates larger than 17 amino acids are not cleaved by thimet oligopeptidase. The cleavage of (GPL)3 to GPL fitted a sequential first-order model. First-order kinetics were unexpected as the initial substrate concentration was greater than Km. The anomaly was also seen during the cleavage of bradykinin and neurotensin, and in these cases first-order behaviour was due to potent competitive inhibition by the C-terminal product. The sequential mechanism for (GPL)3 breakdown by thimet oligopeptidase does not discriminate between initial cleavages towards the N- or C-terminus. As isoleucine is an unfavourable residue in P1, substrates were made in which selected leucine residues were replaced by isoleucine. GPL--GPI--GPL (where--represents the bond between the tripeptide units) was resistant to hydrolysis and GPI--GPL--GPL was cleaved only at the -Leu-Gly- bond. Experiments with isoleucine-containing analogues of (Gly-Hyp-Leu)4 showed that thimet oligopeptidase preferred to cleave these peptides near the C-terminus.

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Knight, C. G. "A quenched fluorescent substrate for thimet peptidase containing a new fluorescent amino acid, DL-2-amino-3-(7-methoxy-4-coumaryl)propionic acid." Biochemical Journal 274, no. 1 (February 15, 1991): 45–48. http://dx.doi.org/10.1042/bj2740045.

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DL-2-Amino-3-(7-methoxy-4-coumaryl)propionic acid, a new fluorescent amino acid (abbreviated to Amp), has been synthesized to provide an alternative to tryptophan in quenched fluorescent peptide substrates for peptidases. The model compound Ac-DL-Amp-NH2 was intensely fluorescent with an excitation maximum at 328 nm and an emission maximum at 392 nm. Fmoc (fluoren-9-ylmethoxycarbonyl)-DL-Amp was made to allow the solid-phase synthesis of Amp-containing peptides by the Fmoc-polyamide method. The peptide derivative Dnp (2,4-dinitrophenyl)-Pro-Leu-Gly-Pro-DL-Amp-D-Lys was cleaved by thimet peptidase at the Leu-Gly bond, with a 20-fold enhancement of fluorescence. The value of kcat./Km for thimet peptidase was 6.7 x 10(5) M-1.s-1, compared with the value of 2.4 x 10(5) M-1.s-1 for the tryptophan-containing analogue, Dnp-Pro-Leu-Gly-Pro-Trp-D-Lys.

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Hayashi, Mirian A. F., Marcelo D. Gomes, Nancy A. Rebouҫas, Beatriz L. Fernandes, Emer S. Ferro, and Antonio C. M. de Camargo. "Species Specificity of Thimet Oligopeptidase (EC 3.4.24.15)." Biological Chemistry Hoppe-Seyler 377, no. 5 (January 1996): 283–92. http://dx.doi.org/10.1515/bchm3.1996.377.5.283.

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Machado, Maurício F. M., Marcelo F. Marcondes, Vanessa Rioli, Emer S. Ferro, Maria A. Juliano, Luiz Juliano, and Vitor Oliveira. "Catalytic properties of thimet oligopeptidase H600A mutant." Biochemical and Biophysical Research Communications 394, no. 2 (April 2010): 429–33. http://dx.doi.org/10.1016/j.bbrc.2010.03.045.

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McCOOL, SUZAN, and ADRIAN R. PIEROTTI. "26 Promoter sequence of rat thimet oligopeptidase." Biochemical Society Transactions 26, no. 1 (February 1, 1998): S15. http://dx.doi.org/10.1042/bst026s015.

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Chen, Jinq-May, Alvin Changco, Molly A. Brown, and Alan J. Barrett. "Immunolocalization of Thimet Oligopeptidase in Chicken Embryonic Fibroblasts." Experimental Cell Research 216, no. 1 (January 1995): 80–85. http://dx.doi.org/10.1006/excr.1995.1010.

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Tisljar, Ursula, and Alan J. Barrett. "A distinct thimet peptidase from rat liver mitochondria." FEBS Letters 264, no. 1 (May 7, 1990): 84–86. http://dx.doi.org/10.1016/0014-5793(90)80771-a.

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Iannetta, Anthony A., Holden T. Rogers, Thualfeqar Al‐Mohanna, Juliana N. O’Brien, Andrew J. Wommack, Sorina C. Popescu, and Leslie M. Hicks. "Profiling thimet oligopeptidase‐mediated proteolysis in Arabidopsis thaliana." Plant Journal 106, no. 2 (February 17, 2021): 336–50. http://dx.doi.org/10.1111/tpj.15165.

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Dissertations / Theses on the topic "Thimet"

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Morrison, Lesley S. "Thimet oligopeptidase : gene expression and function." Thesis, Glasgow Caledonian University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404681.

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McCool, Suzan. "Regulation of thimet oligopeptidase gene expression in the male reproductive system." Thesis, Glasgow Caledonian University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285223.

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Lim, Eun Jeong. "STRUCTURAL AND FUNCTIONAL STUDIES OF SYNAPTIC ENZYMES." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/259.

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Thimet oligopeptidase (TOP, EC 3.4.24.15) and neurolysin (EC 3.4.24.16) are zincdependent metallopeptidases that metabolize small bioactive peptides. The two enzymes share60 % sequence identity and their crystal structures demonstrate that they adopt nearly identicalfolds. They generally cleave at the same sites, but they recognize different positions on somepeptides, including neurotensin, a 13-residue peptide involved in modulation of dopaminergiccircuits, pain perception, and thermoregulation.On the basis of crystal structures and previous mapping studies, four residues(E469/R470, M490/R491, H495/N496, and R498/T499, TOP residues listed first) in thesubstrate-binding channel appear positioned to account for differences in specificity. TOPmutated to the neurolysin residues at all four position cleaves neurotensin at the neurolysin siteand neurolysin mutated to the TOP residues at all four sites cleaves at the TOP position. Using aseries of constructs mutated at only three sites, it was determined that only two of the mutations,E469/R470 and R498/T499, are required to swap the specificity of TOP and neurolysin. Theseresults were confirmed by testing the two mutation constructs, and either single mutant of TOPshown an intermediate specificity, cleaving at both sites.Crystal structures of the two mutation constructs of TOP and neurolysin unligandedforms, the mutations do not perturb local structure, but side chain conformations at theR498/T499 position differ from those of the mimicked enzyme. A model for differentialrecognition of neurotensin based on differences in surface charge distribution in the substratebinding sites is proposed. The model is supported by finding that reducing the positive charge onthe peptide results in cleavage at both hydrolysis sites.This dissertation also includes a description of the production and crystallization trials ofhuman neprilysin (E.C. 3.4.24.11), which will be used as another model system for studyingspecificity in metallopeptidases. In addition, the production and crystallization, and crystalcharacterization of human choline acetyltransferase (EC 2.3.1.6) is described.

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Gravi, Ellen Tihe [UNIFESP]. "Identificação de atividade metalo-oligopeptidásica Thimet-like em Paracoccidioides brasiliensis: um novo fator de patogenicidade fúngica?" Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9696.

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Made available in DSpace on 2015-07-22T20:50:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-10-28
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Paracoccidioides brasiliensis (Pb), é uma micose sistêmica grave com formas aguda e crônica. As proteases ou peptidases são enzimas proteolíticas que ocorrem em todos os organismos e correspondem a 1-5% de seus conteúdos genéticos. Estas enzimas estão envolvidas em processos biológicos essenciais, como a coagulação sanguínea, morte celular e diferenciação de tecidos. Várias etapas proteolíticas importantes ocorrem durante a invasão metastática de tumores, assim como no ciclo de infecção de um grande número de vírus e microrganismos patogênicos. Um número reduzido de proteases do Pb já foram isoladas e caracterizadas, tampouco sua atividade durante o desenvolvimento da doença foi determinado, e até o momento, nenhuma atividade oligopeptidásica foi descrita nesse fungo. No presente trabalho foi demonstrada a presença de uma atividade metalo-peptidásica thimet oligopeptidase (TOP)-like no extrato citosólico de leveduras de P. brasiliensis, isolado 18 (Pb18). Nossos resultados mostraram a hidrólise do peptídeo com supressão intramolecular de fluorescência Abz-GFSPFRQ-EDDnp pelo extrato citosólico de leveduras de P. brasiliensis. Esse substrato é clivado preferencialmente pela TOP de mamíferos, e corroborando esse resultado, observou-se a inibição da hidrólise desse peptídeo por ο-fenantrolina e JA-2, inibidores seletivos de metalo-proteases e TOP, respectivamente. Utilizando-se peptídeos e inibidores seletivos para diferentes proteases, não se detectou a presença de atividade neurolisina-like ou neprilisina-like, e também se descartou a presença de serino-peptidases, cisteíno-peptidases e enzima conversora da angiotensina I. A maior atividade enzimática do extrato citosólico sobre os outros preparados (membrana/parede celular ou lisado total das leveduras) pode indicar uma localização citosólica dessa enzima. Não foi observada a secreção da peptidase no sobrenadante de cultura in vitro, mesmo após adição de soro fetal bovino. Todavia, a peptidase com atividade TOP-like de Pb parece ser secretada in vivo, ou liberada após lise do fungo por componentes efetores da resposta imune, uma vez que anticorpos capazes de inibir a atividade peptidásica são encontrados em soros de pacientes com paracoccidioidomicose, e soros com maior título em imunodifusão contém maiores concentrações de anticorpos enzima-específicos. Várias enzimas da família M3 clivam bradicinina, importante mediador inflamatório in vivo. A hidrólise da bradicinina e do substrato Abz-GFSPFRQEDDnp pelo extrato citosólico de P. brasiliensis, gera os mesmos fragmentos observados após clivagem pela TOP de mamíferos, que são diferentes dos gerados pela clivagem com MIP de mamíferos e OpdA bacteriana, sendo mais um indicador da presença majoritária de uma peptidase com atividade TOP-like em P. brasiliensis. A clivagem da bradicinina pela metalooligopeptidase com atividade TOP-like de Pb, poderia ocorrer no sítio inflamatório e poderia estar envolvida na inibição da indução de uma resposta imune protetora contra o fungo, favorecendo a permanência do mesmo no hospedeiro. Observamos ainda que o gene homólogo de TOP em P. brasiliensis é quase duas vezes mais expresso no virulento em comparação ao não virulento. O aumento da hidrólise do substrato Abz-GFSPFRQ-EDDnp também foi observado no isolado de maior virulência quando comparado ao de menor virulência. A possível relação entre a expressão da metalooligopeptidase com a virulência do fungo sugere que essa peptidase possa ser classificada como um fator de virulência fúngica, no entanto experimentos complementares são necessários para sua confirmação. A expressão da gp43 também foi analisada no isolado virulento e não virulento e observou-se uma expressão aumentada em até treze vezes no primeiro. Para melhor caracterização dessas metalo-oligopeptidases é necessária a obtenção da proteína recombinante, ou da proteína purificada nativa, isolada do lisado fúngico. Não obtivemos sucesso na expressão das proteínas recombinantes, tampouco no isolamento da peptidase nativa por métodos cromatográficos. Nossos resultados sugerem a presença de uma atividade metalooligopeptidásica TOP-like na fração citosólica de leveduras de P. brasiliensis. Liberação in vivo dessa enzima após a lise de fungos ou secreção estimulada por fatores do hospedeiro, pode ter um papel na inflamação e desenvolvimento da micose.
Paracoccidioidomycosis (PCM), caused by the pathogenic fungus Paracoccidioides brasiliensis (Pb) is a systemic mycosis with severe acute and chronic forms. Proteases or peptidases are proteolytic enzymes that occur in all organisms and constitute 1-5% of their genetic contents. These enzymes are involved in biological processes such as blood clotting, cell death and tissue differentiation. Several important proteolytic steps occur during the invasion of metastatic tumors, as well as in the infection of a large number of viruses and pathogens. To date, a small number of Pb proteases were isolated and characterized, also, their activities during the development of the disease was not determined, and an oligopeptidase activity was not detected in this fungus. In the present work, we demonstrated a metallopeptidase thimet oligopeptidase (TOP)-like activity in the cytosolic extract of Pb18 yeasts. Our results shown a major hydrolysis of the fluorescence resonance energy transfer (FRET) peptide Abz-GFSPFRQ-EDDnp, preferentially cleaved by TOP from mammals, and the inhibition of the hydrolysis of this peptide by orthophenantrolin and JA-2, selective inhibitors of metalloproteases and TOP, respectively. The presence of neurolysin- like and neprilysin-like, serinepeptidases, cysteine-peptidases and angiotensin converting enzyme I was discarded by analyzing selective FRET peptides and inhibitors. The higher peptidase activity of cytosolic extracts over the membrane/cell wall and total yeast lysate preparations may indicate that this enzyme is localized in the yeast cytosol. The metallo-oligopeptidase activity was not detected on in vitro culture supernatants, even after addition of fetal calf serum. However, the peptidase with TOP-like activity of P. brasiliensis seems to be secreted in vivo, or released after fungal lysis by immune factors, since antibodies that can inhibit this enzymatic activity were found in sera from paracoccidioidomycosis patients, and serum with highest titer in immunodiffusion contains higher concentrations of enzymespecific antibodies. Bradykinin, an important inflammatory mediator in vivo, is cleaved by several enzymes from the M3 family. The same fragments observed after hydrolysis by TOP were observed after cytosolic extract hydrolysis of bradykinin and the substrate Abz-GFSPFRQ-EDDnp. MIP and bacterial OpdA hydrolysis of these peptides generate different fragments, and this is an additional indicator of a major TOP-like activity in P. brasiliensis yeast cells Bradykinin hydrolysis by the TOP-like metallopeptidase of P. brasiliensis may occur in inflammatory processes and this suggests that the enzyme may be involved in the inhibition of a protective anti-fungal response induction, limiting fungal elimination. We also observed that the expression of the TOP homologous gene in P. brasiliensis has almost a two-fold increased in the virulent isolate 18 compared to the non-virulent isolate. Increased hydrolysis of the substrate Abz-GFSPFRQ-EDDnp was also observed in the most virulent isolate compared to the non-virulent. The possible correlation between TOP-like peptidase expression and fungal virulence suggests that this peptidase could be classified as a fungal virulence factor, however, additional experiments are needed to confirm this hypothesis. Gp43 expression was also analyzed in both isolates, and it was observed a thirteen-fold increase in the expression on the virulent isolate. In order to better characterize the P. brasiliensis TOP-like activity, we attempted to obtain the purified recombinant or the native protein, isolated from fungal lysate. However, we were not successful in the expression of recombinant proteins and neither on the isolation of the native protein using chromatographic methods. Our results suggest the presence of a TOP-like activity in the cytosolic fraction of P. brasiliensis yeasts. In vivo release of this enzyme after fungal lysis, or host factors-stimulated secretion, may have a role in inflammation and development of the disease.
TEDE
BV UNIFESP: Teses e dissertações

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Wagner, Jonathan Mark. "STRUCTURAL BASIS OF SUBSTRATE RECOGNITION IN THIMET OLIGOPEPTIDASE AND DEVELOPMENT OF NANOPARTICLES FOR THERAPEUTIC ENZYME DELIVERY." UKnowledge, 2012. http://uknowledge.uky.edu/biochem_etds/6.

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Neuropeptidases are responsible for degradation of signaling peptides in the central nervous system and periphery. Some neuropeptidases have also been shown to play a role as part of the cell’s hydrolytic machinery responsible for breaking down proteins and peptides into amino acids, and these enzymes therefore influence small peptide availability for antigen presentation. A better understanding of how neuropeptidases recognize their substrates could lead to therapeutics that modulate the activity of these important enzymes. Alternatively, re-engineering these enzymes to selectively hydrolyze undesirable peptides could make them attractive as therapeutics themselves. A key question in understanding the activity of these enzymes is how they are able to recognize a variety of seemingly unrelated amino acid sequences as cleavage sites. We are investigating the basis for this general substrate recognition in neuropeptidases using thimet oligopeptidase (TOP) as a model. Crystal structures of TOP in complex with a variety of substrates and inhibitors shed light on the mechanisms underlying substrate recognition and pave the way for re-targeting substrate recognition in these enzymes. Nano test tube particles have been proposed as a means of delivering therapeutics such as enzymes. However, the template synthesis method for nano test tube production does not produce therapeutic quantities. In order to take full advantage of re-engineered neuropeptidases a new method for nano test tube synthesis has been developed. We show that a non-destructive template synthesis methodology can be applied to produce nano test tube particles in quantities useful for therapeutic enzyme immobilization.

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BOUDJENNAH, LAZIZ. "Proteolyse des matrices extracellulaires associee a l'invasion tumorale : caracterisation et isolement d'une nouvelle activite gelatinase de type thimet issue du domaine liant la gelatine de la fibronectine." Paris 6, 1998. http://www.theses.fr/1998PA066424.

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La formation des metastases cancereuses implique une surexpression de proteases provoquant la digestion des matrices extracellulaires. La surexpression des genes des principaux types de proteases est maintenant bien etablie dans de nombreux cancers humains. Des fragments de fibronectine provenant de la proteolyse menagee d'une matrice extracellulaire modele par une cysteine-protease sont purifies par quatre chromatographies d'affinites. Ces fragments presentent une activite collagenase/gelatinase apres maturation dans des conditions particulieres. Cette activite a ete etudiee par zymographie et au moyen de substrats specifiques des mmps (metalloproteases matricielles impliquees dans la digestion des collagenes). Une etude avec des inhibiteurs a permis de classer cette nouvelle enzyme comme une metalloprotease zinc-dependante n'appartenant pas a la famille des mmps. Cette protease appartient a la famille des thiol-metalloproteases (thimet). Cette activite serait impliquee dans les mecanismes de migration cellulaire (embryogenese, formation des metastases).

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Waldréus, Nana. "Thirst in Patients with Heart Failure : Description of thirst dimensions and associated factors with thirst." Doctoral thesis, Linköpings universitet, Hälsa, Aktivitet, Vård (HAV), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-126151.

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Introduction: Nurses and other health care professionals meet patients with heart failure (HF) who report they are thirsty. Thirst is described by the patients as a concern, and it is distressing. Currently there are no standardized procedures to identify patients with increased thirst or to help a patient to manage troublesome thirst and research in the area of thirst is scarce. In order to prevent and relieve troublesome thirst more knowledge is needed on how thirst is experienced and what factors cause increased thirst. Aim: The aim of this thesis was to describe the thirst experience of patients with HF and describe the relationship of thirst with physiologic, psychologic and situational factors. The goal was to contribute to the improvement of the care by identifying needs and possible approaches to prevent and relieve thirst in patients with HF. Methods: The studies in this thesis used a cross-sectional design (Study I) and prospective observational designs (II-IV). Studies include data from patients with HF who were admitted to the emergency department for deterioration in HF (I, IV) or visited an outpatient HF clinic for worsening of HF symptoms (III); others were patients who were following up after HF hospitalization (II), and patients with no HF diagnosis who sought care at the emergency department for other illness (I). Patients completed questionnaires on thirst intensity, thirst distress, HF self-care behaviour, feeling depressive and feeling anxious. Data on sociodemographic, clinical characteristics, pharmacological treatment and prescribed fluid restriction were retrieved from hospital medical records and by asking the patients. Data were also collected from blood, urine and saliva samples to measure biological markers of dehydration, HF severity and stress. Results: Thirst was prevalent in 1 out of 5 patients (II) and 63% of patients with worsening of HF symptoms experienced moderate to severe thirst distress at hospital admission (IV). Patients at an outpatient HF clinic who reported thirst at the first visit were more often thirsty at the follow-up visits compared to patients who did not report thirst at the first visit (II). Thirst intensity was significantly higher in patients hospitalized with decompensated HF compared to patients with no HF (median 75 vs. 25 mm, visual analogue scale [VAS] 0-100 mm; P < 0.001) (I). During optimization of pharmacological treatment of HF, thirst intensity increased in 67% of the patients. Thirst intensity increased significantly more in patients in the high thirst intensity group compared to patients in the low thirst intensity group (median +18 mm vs. -3 mm; P < 0.001) (III). Patients who were admitted to the hospital with high thirst distress continued to have high thirst distress over time (IV). A large number of patients were bothered by thirst and feeling dry in the mouth when they were thirsty (III, IV). Patients with a fluid restriction had high thirst distress over time and patients who were feeling depressed had high thirst intensity over time (IV). Thirst was associated with fluid restriction (III-IV), a higher serum urea (IIIII), and depressive symptoms (II). Conclusions: A considerable amount of patients with HF experiences thirst intensity and thirst distress. Patients who reported thirst at the first follow-up more often had thirst at the subsequent follow-ups. The most important factors related to thirst intensity or thirst distress were a fluid restriction, a higher plasma urea, and depressive symptoms. Nurses should ask patients with HF if they are thirsty and measure the thirst intensity and thirst distress, and ask if thirst is bothering them. Each patient should be critically evaluated if a fluid restriction really is needed, if the patient might be dehydrated or needs to be treated for depression.

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Baird, Katlyn Marie. "Thicket." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1619442995285422.

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Kauppi, Erika Donnelly. "A Thirst for More." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/1652.

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A Thirst for Moretakes the reader on a journey into self-development culture around Portland, Oregon. The author attends events devoted to personal growth to try to understand how this culture shapes our lives and the way we think. Along the way, she encounters psychics, mystics, an alleged cult leader, and seekers and self-reinventors of all stripes. As participants in this culture work to build their own philosophies and define their own spirituality, they also create their own communities--intentionally and otherwise. These communities form the heart of this exploration. Chapters 1 and 2 explore the spontaneous communities that arise during afternoon events in which participants pay for goods, services, and information pertaining to personal growth and spirituality. Chapter 3 delves into a sacred art and music festival in which participants gather outdoors for a handful of days in the hopes of connecting with each other and transforming themselves--and society--in the process. The final chapters explore the lives of two communities. In Chapter 4, a woman devotes her life to starting up an eco-village in the foothills of Mt. Hood. In Chapter 5, the author visits a 41-year-old commune in which residents and visitors have abandoned former lives in their search for meaning, fulfillment, belonging, and a place to call home. As the author questions others about their beliefs, she begins to question her own. Why do we believe what we believe?

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Gournay, Dominique. "Thibet de Victor Segalen : itinéraire d'une esthétique a une poétique." Paris 10, 1995. http://www.theses.fr/1995PA100164.

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Pour mieux cerner la nature de Thibet, la dernière œuvre écrite par Victor Segalen, la première partie de la thèse expose quelques aspects majeurs de son esthétique. L'essai sur l'exotisme fournit des repères théoriques. Les écrits de Segalen consacrés a la musique, à la peinture et à la sculpture montrent la spécificité de chaque art et le statut dévolu tant à l'artiste qu'a ses œuvres. Le double Rimbaud, peintures, équipée éclairent les ambitions et les limites de la création poétique. Thibet se trouve ainsi place dans le cadre d'une quête esthétique et ontologique. La deuxième partie s'arrête sur les éléments propres a constituer la poétique de Thibet. Malgré les incertitudes liées a l'inachèvement du poème, la cohérence de l'œuvre apparait dans la succession des séquences comme dans la récurrence des thèmes. Un Tibet originel s'y trouve érigé en symbole; il est l'objet du poème qui cherche paradoxalement à atteindre le divers et l'autre inaccessibles. Segalen organise puissamment son chant poétique en usant des multiples ressources de la métrique, du rythme et des effets sonores. Des références littéraires et liturgiques contribuent à éclairer les principes de la composition du poème
This dissertation attempts to assess the specificity of Thibet, Segalen's last poem. The first part of the dissertation deals with some of the major aspects of Segalen's aesthetics. The Essai sur l'exotisme furnishes theoretical data. Besides Segalen's writings on music, painting and sculpture confirm the poet's belief in the originality of artistic achievements and the particular status of the artist and his work. Double Rimbaud, painters equipped expound the aims and set the limits of poetic creation. Thibet thus appears as the ultimate aesthetic and ontological quest. The second part of the dissertation analyses the components of poetry in Thibet. Despite uncertainties due to the fact that the poem is unfinished, Thibet has a coherence of its own thanks to the succession of sequences and recurring themes. A kind of primeval Thibet is thus turned into a symbol. The poem then becomes an attempt to capture multiplicity and otherness. Segalen builds up a powerful poetic song, making use of all the devices of prosody, rhythm and sound-effects. Literary and liturgical references help to understand the underlying rules of poetic composition

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Books on the topic "Thimet"

1

Alpérine, Paul. Ombre sur le Thibet. Paris: Kailash, 1998.

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Firnkees, N. Kerstin Thieme. Tutzing: H. Schneider, 1988.

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Kelton, Elmer. Dark thicket. Bath: Chivers, 1993.

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Tozaj, Neshat. Thikat: Roman. Tiranë: Shtëpia Botuese "Naim Frashëri", 1989.

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Boileau, Pierre. Ta Thimata. Athens: Kastaniotis, 1999.

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The thicket. Waterville, Maine: Thorndike Press, a part of Gale, Cengage Learning, 2014.

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Kelton, Elmer. Dark thicket. Thorndike, Me: G.K. Hall, 1993.

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Dark thicket. Garden City, N.Y: Doubleday, 1985.

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Thimo thime: The Gĩkũyũ idioms. Nairobi: Lantana General Agencies, 2002.

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Histoire de la mission du Thibet. Paris: Missions étrangères de Paris, 2001.

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Book chapters on the topic "Thimet"

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Norgren, R. "Sensory Detection of Water." In Thirst, 221–31. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_13.

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Baylis, P. H. "Effect of Changes in Reproductive Status on Fluid Intake and Thirst." In Thirst, 443–52. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_29.

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Fitzsimons, J. T. "Evolution of Physiological and Behavioural Mechanisms in Vertebrate Body Fluid Homeostasis." In Thirst, 3–22. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_1.

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Oldfield, B. J. "Neurochemistry of the Circuitry Subserving Thirst." In Thirst, 176–93. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_10.

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Stricker, E. M. "Central Control of Water and Sodium Chloride Intake in Rats During Hypovolaemia." In Thirst, 194–206. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_11.

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Nicolaïdis, S., M. El Ghissassi, and S. N. Thornton. "Rostro-Sagittal Brain: Site of Integration of Hydrational Signals in Body Fluid Regulation and Drinking." In Thirst, 207–18. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_12.

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Schallert, T. "Neostriatal Mechanisms Affecting Drinking." In Thirst, 232–40. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_14.

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Zeigler, H. P. "Drinking in Mammals: Functional Morphology, Orosensory Modulation and Motor Control." In Thirst, 241–57. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_15.

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Travers, J. B. "Drinking: Hindbrain Sensorimotor Neural Organization." In Thirst, 258–75. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_16.

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Holland, P. C. "Learning, Thirst and Drinking." In Thirst, 279–95. London: Springer London, 1991. http://dx.doi.org/10.1007/978-1-4471-1817-6_17.

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Conference papers on the topic "Thimet"

1

Popescu, Sorina. "Redox-sensitive thimet oligopeptidases TOP1 and TOP2 are required for immune signaling and systemic acquired immunity." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1332401.

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Gamrekelashvili, Jaba, Tamar Kapanadze, Josef Wissing, Chi Ma, Lothar Jaensch, Firouzeh Korangy, and Tim F. Greten. "Abstract B30: Cross-priming of CD8+ T cells is controlled by dipeptidyl peptidase 3 and thimet oligopeptidase 1 present in necrotic cells." In Abstracts: AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; December 2-5, 2012; Miami, FL. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tumimm2012-b30.

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Kennerly, Ethan, Andreas Witzel, and Jonathan A. Zvesper. "Thief belief." In 2009 International IEEE Consumer Electronics Society's Games Innovations Conference (ICE-GIC 2009). IEEE, 2009. http://dx.doi.org/10.1109/icegic.2009.5293592.

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Luo, Jian-Hao, Jianxin Wu, and Weiyao Lin. "ThiNet: A Filter Level Pruning Method for Deep Neural Network Compression." In 2017 IEEE International Conference on Computer Vision (ICCV). IEEE, 2017. http://dx.doi.org/10.1109/iccv.2017.541.

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Li, Qifen, Sili Li, Shunquan Tan, and Bin Li. "ThiNet Based Pruning Method for GAN Based Steganography Framework UT-GAN." In 2021 International Symposium on Signals, Circuits and Systems (ISSCS). IEEE, 2021. http://dx.doi.org/10.1109/isscs52333.2021.9497448.

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Maksimova, Ekaterina, Ekaterina Maksimova, Vladimir Zhigulsky, Vladimir Zhigulsky, Vladimir Shuisky, and Vladimir Shuisky. "ASSESSMENT OF THE SPATIOTEMPORAL DYNAMICS OF THE MACROPHYTE THICKET ECOSYSTEMS IN THE NEVA BAY AND THE ADJACENT WATERS OF THE EASTERN GULF OF FINLAND." In Managing risks to coastal regions and communities in a changing world. Academus Publishing, 2017. http://dx.doi.org/10.21610/conferencearticle_58b431672d7ed.

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The macrophyte thicket ecosystems of higher aquatic vegetation in the Neva Bay (NB) and Eastern Gulf of Finland (EGoF) perform many important roles, including acting as the habitats, nesting sites and migration sites for aquatic and semi-aquatic birds, creating the specific conditions necessary for the spawning and growth of many species of fish, and taking part in the self-purification of the aquatic ecosystems. Many anthropogenic disturbances, hydraulic works in particular, have a significant negative impact on these macrophyte thicket ecosystems. In recent years, the active growth of a new type of macrophyte thicket has been observed in the NB. This is due to the aftereffects of the construction of the Saint Petersburg Flood Prevention Facility Complex (FPFC). It is quite likely that the total macrophyte thicket area in these waters is currently increasing. In the future, it will be necessary to assess the environmental impacts of the hydraulic works on the macrophyte thicket of the NB and EGoF, taking into account the background processes of the spatiotemporal dynamics of the reed beds in the waters in question. To do this, it will be necessary to carry out a comprehensive study of these ecosystems and identify patterns in their spatial and temporal dynamics. The program of the study has been developed and is currently being implemented by Eco-Express-Service, a St. Petersburg eco-design company.

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Maksimova, Ekaterina, Ekaterina Maksimova, Vladimir Zhigulsky, Vladimir Zhigulsky, Vladimir Shuisky, and Vladimir Shuisky. "ASSESSMENT OF THE SPATIOTEMPORAL DYNAMICS OF THE MACROPHYTE THICKET ECOSYSTEMS IN THE NEVA BAY AND THE ADJACENT WATERS OF THE EASTERN GULF OF FINLAND." In Managing risks to coastal regions and communities in a changing world. Academus Publishing, 2017. http://dx.doi.org/10.31519/conferencearticle_5b1b93849b8ce5.05692343.

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The macrophyte thicket ecosystems of higher aquatic vegetation in the Neva Bay (NB) and Eastern Gulf of Finland (EGoF) perform many important roles, including acting as the habitats, nesting sites and migration sites for aquatic and semi-aquatic birds, creating the specific conditions necessary for the spawning and growth of many species of fish, and taking part in the self-purification of the aquatic ecosystems. Many anthropogenic disturbances, hydraulic works in particular, have a significant negative impact on these macrophyte thicket ecosystems. In recent years, the active growth of a new type of macrophyte thicket has been observed in the NB. This is due to the aftereffects of the construction of the Saint Petersburg Flood Prevention Facility Complex (FPFC). It is quite likely that the total macrophyte thicket area in these waters is currently increasing. In the future, it will be necessary to assess the environmental impacts of the hydraulic works on the macrophyte thicket of the NB and EGoF, taking into account the background processes of the spatiotemporal dynamics of the reed beds in the waters in question. To do this, it will be necessary to carry out a comprehensive study of these ecosystems and identify patterns in their spatial and temporal dynamics. The program of the study has been developed and is currently being implemented by Eco-Express-Service, a St. Petersburg eco-design company.

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Robertson, Judy. "Cheerful confusion and a thirst for knowledge." In WiPSCE '18: Workshop in Primary and Secondary Computing Education. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3265757.3265758.

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Sedbrook, John, Zane Edwards, and Jay Edwards. "Fast Track Relief to Midland’s Emergency Thirst." In Pipelines 2015. Reston, VA: American Society of Civil Engineers, 2015. http://dx.doi.org/10.1061/9780784479360.043.

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Toản, Phạm Văn, and Ngô Thanh Bình. "Nghiên cứu, thiết kế và chế tạo thiết bị tự động dán kẹo sáo." In HNKH toàn quốc lần thứ 3 về điều khiển & Tự động hoá. Publishing House for Science and Technology, 2016. http://dx.doi.org/10.15625/vap.2015.0035.

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Reports on the topic "Thimet"

1

Kauppi, Erika. A Thirst for More. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1651.

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Eckel, Mark E. Geopolitical Dilemmas of China's Growing Thirst for Oil. Fort Belvoir, VA: Defense Technical Information Center, March 2004. http://dx.doi.org/10.21236/ada427639.

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Hegde, Deepak, David Mowery, and Stuart Graham. Pioneers, Submariners, or Thicket-builders: Which Firms Use Continuations in Patenting? Cambridge, MA: National Bureau of Economic Research, June 2007. http://dx.doi.org/10.3386/w13153.

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Gunther, Jilenne. The Thief Who Knows You: The Cost of Elder Exploitation Examined. AARP Public Policy Institute, March 2020. http://dx.doi.org/10.26419/ppi.00095.001.

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Gunther, Jilenne. The Thief Who Knows You: The Cost of Financial Exploitation One-Page Summary. AARP Public Policy Institute, March 2020. http://dx.doi.org/10.26419/ppi.00095.002.

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Stanbro, W. D., and P. W. Henriksen. THIEF, Version 1. 0: An interactive simulation of nuclear materials safeguards and security. Office of Scientific and Technical Information (OSTI), February 1991. http://dx.doi.org/10.2172/6242486.

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Bacani, Eleanor, and Shinjini Mehta. Analyzing the Welfare-Improving Potential of Land Pooling in Thimphu City, Bhutan: Lessons Learned from ADB’s Experience. Asian Development Bank, November 2020. http://dx.doi.org/10.22617/wps200315-2.

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This paper examines empirically and spatially how welfare gains are realized in a land pooling scheme in four ADB-financed Local Area Plans (LAPs) in Thimphu city, Bhutan. Increased government efforts are required to take advantage of the full range of benefits of land pooling for Thimpu residents. The paper recommends a mix of fiscal and urban policy levers to address inefficiencies associated with the existing build-out pattern and infrastructure service quality. It offers insights on how unplanned development occurring outside serviced LAP areas, including along steep slopes and peri-urban areas in Thimphu thromdes, can be addressed most effectively. This paper is the second in a series of three working papers on the topic of land pooling produced by the Asian Development Bank’s South Asia Urban Development and Water Division. The series takes a deeper look at aspects including land pooling’s effectiveness, welfare-improving potential, relationship with safeguard policies, and its prospects as a land management tool in developing country cities.

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Baseline assessment of fish communities, benthic macroinvertebrate communities, and stream habitat and land use, Big Thicket National Preserve, Texas, 1999-2001. US Geological Survey, 2003. http://dx.doi.org/10.3133/wri034270.

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