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Academic literature on the topic 'Thiazoloquinazolinones'
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Journal articles on the topic "Thiazoloquinazolinones"
Fakhari, Ali, Kobra Hasheminasab, Hamid Ahmar, and Abdolali Alizadeh. "An Efficient Synthesis of Thio- and Thiazoloquinazolinones by the Electrochemical Oxidation of Catechols in the Presence of 2-Mercapto-4(3H)-quinazolinone." Synthesis 2008, no. 24 (December 2008): 3963–66. http://dx.doi.org/10.1055/s-0028-1083258.
Full textAlexandre, François-René, Amaya Berecibar, Roger Wrigglesworth, and Thierry Besson. "Efficient synthesis of thiazoloquinazolinone derivatives." Tetrahedron Letters 44, no. 24 (June 2003): 4455–58. http://dx.doi.org/10.1016/s0040-4039(03)01026-8.
Full textTestard, Alexandra, Laurent Picot, Olivier Lozach, Melina Blairvacq, Laurent Meijer, Laurence Murillo, Jean-Marie Piot, Valérie Thiéry, and Thierry Besson. "Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors." Journal of Enzyme Inhibition and Medicinal Chemistry 20, no. 6 (January 2005): 557–68. http://dx.doi.org/10.1080/14756360500212399.
Full textMobinikhaledi, A., N. Foroughifar, S. Ebrahimi, F. Rahimi, and F. Zandi. "Synthesis of Some Novel 2-Arylidene Thiazoloquinazolinone Derivatives via One-Pot, Three-Component Reaction." Phosphorus, Sulfur, and Silicon and the Related Elements 186, no. 3 (February 28, 2011): 457–63. http://dx.doi.org/10.1080/10426507.2010.503210.
Full textOrysyk, V. V., Yu L. Zborovskii, V. I. Staninets, A. A. Dobosh, and S. M. Khripak. "Synthesis of Thiazino- and Thiazoloquinazolinones by Cyclization of S-(2-Propenyl) Derivatives of 2-Thioxo-2,3-dihydro-4(1H)-quinazolinone." ChemInform 35, no. 9 (March 2, 2004). http://dx.doi.org/10.1002/chin.200409131.
Full textFakhari, Ali Reza, Kobra Hasheminasab, Hamid Ahmar, and Abdolali Alizadeh. "ChemInform Abstract: An Efficient Synthesis of Thio- and Thiazoloquinazolinones by the Electrochemical Oxidation of Catechols in the Presence of 2-Mercapto-4(3H)-quinazolinone." ChemInform 40, no. 17 (April 28, 2009). http://dx.doi.org/10.1002/chin.200917166.
Full textAlexandre, Francois-Rene, Amaya Berecibar, Roger Wrigglesworth, and Thierry Besson. "Efficient Synthesis of Thiazoloquinazolinone Derivatives." ChemInform 34, no. 37 (September 16, 2003). http://dx.doi.org/10.1002/chin.200337128.
Full textDissertations / Theses on the topic "Thiazoloquinazolinones"
Testard, Alexandra. "Synthèse de thiazoloquinazolinones angulaires N-Alkylees à visée thérapeutique." La Rochelle, 2006. http://www.theses.fr/2006LAROS158.
Full textThe protein kinases constitute an important family involved in numerous cellular functions. So it’s an important target for the potential therapeutic interest. In order to obtain new inhibitor family, the multistep synthesis of : 8-substituted-9-oxo-8,9-dihydrothiazolo[5,4-f]- quinazoline -2- carbonitrile, 7-substituted-6-oxo-6,7-dihydro-thiazolo[4,5-h]-quinazoline-2-carbonitril 8-substituted-9-oxo-8, 9-dihydrothiazolo[5,4-f]-quinazoline-2,7-dicarbonitrile was investigated. This compounds were prepared via the 4,5-dichloro-1,2,3-dithiazolium chloride chemistry. And the synthesis was optimized under micro-wave irradiation. The inhibition of Cyclin Dependant Kinase (CDKs) and Glycogen Synthase Kinase 3 (GSK-3) was evaluated. Moreover, a structure activity relationship was determined with molecular modeling
Broudic, Nathan. "Chimie du Sel d'Appel et des Acides Anthraniliques pour la synthèse de nouveaux hétérocycles." Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR036.
Full textFor more than twenty years, our research group has been synthesizing original heterocyclic structures to identify new inhibitors of the DYRK1A kinase, involved in neurodegenerative diseases. The thiazolo[5,4-f]quinazolines and quinazolinones EHT1610 and FC162, discovered in our laboratory, have been shown to significantly inhibit DYRK1A activity. This thesis aims to develop novel synthetic routes for linear regioisomers of EHT1610 and FC162 to verify experimentally the impact of angular geometry on their biological activity. A pallado-catalysed cyclisation of N-arylcyanothioformamides to 2-cyanobenzo[d]thiazoles was developed and applied for the synthesis of new linear polyfunctional benzothiazoles. These compounds were then used in a reaction inspired by Niementowski and Bischler-Napieralski condensations to create a new chemical library of original thiazolo-alkaloids. At least, linear analogues of EHT1610 and FC162 were also isolated for the first time. Their biological evaluation showed that the linear geometries were inactive on eight kinases, while the thiazolo[5,4-g]quinazolinone structure was cytotoxic at micromolar concentrations on seven cancer lines. A divergent modulation strategy was used to synthesise fifty new compounds. Compound 261 was shown to be active at nanomolar concentrations on all cancer lines by inducing senescence, without affecting healthy cells