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Dissertations / Theses on the topic 'Theraputic'
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1
Harrison, Susan A. "Potential theraputic target proteins in human neuroblastoma cells." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506531.
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Foster, Clive H. "Drug users in a theraputic cul-de-sac." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20511.
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Okolie, Charles 'Emeka. "Development of Diagnostic and Theraputic Tools for Staphylococcus aureus Infections." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517830.
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Coffield, Linda. "The impact of a theraputic group procedure on self-differentiation." Online version, 2000. http://www.uwstout.edu/lib/thesis/2000/2000coffieldl.pdf.
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Park, Ji. "PRMT5 as a potential theraputic target for MYCN overexposing peadiatric cancers." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.743007.
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Cook, Sarah. "The Revolutionary Theraputic Qualities in the Poetry of Wilfred Owen and Siegfried Sassoon." Kent State University Honors College / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1375714481.
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Allanson, Amy Louise. "Determination of tuberculosis drugs in human plasma and blood spots: a potential method for theraputic drug monitoring." Thesis, University of Strathclyde, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488517.
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Schwartz, Robert Lee. "Vestibular and Electromagnetic Stimulation: Their Effects on Intellectual Performance and Mood State." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc332751/.
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In the present study, the Electromechanical Therapeutic Apparatus was examined to determine the extent to which its repeated use can influence intellectual performance and mood state. The Electromechanical Therapeutic Apparatus is a device designed to mildly stimulate the body and brain, while facilitating relaxation. Its three components include a rotating platform-bed; a weak, extremely-low-frequency, external-electric field; and music. In the present study, three groups were contrasted, a music-only group which served as a placebo; a group which combined motion-vestibular stimulation and music; and a group which combined motion-vestibular stimulation and music with an externalelectric field. The sample included 33 randomly selected men and women whose average age was 34.6 years.
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Rosshagen, Richard. "Utredningsförfarandet inom barn- och ungdomspsykiatrin: hur skapar vi mervärde för familjerna? : ”Therapeutic Assessment with Children and Families” (TA-C) jämfört med Traditionella Ut- redningar (TU) – en randomiserad kontrollerad pilot-studie." Thesis, Umeå universitet, Psykoterapi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118511.
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Tidigare amerikanska studier av utredningsmetoden ”Therapeutic Assessment with Children and Families” (TA-C) visar att föräldrar så väl som barn upplever förbättringar av barnets psykiatriska symptom, samt av familjens globala funktionsförmåga och emotionella relaterande under utredningsprocessen. TA-C leder också till en ökad tillfredsställelse med den behandling som sedan erbjudits. Metod: En randomiserad kontrollerad pilotstudie inkluderande totalt 12 barn mellan 7-10 år och deras familjer genomfördes på en BUP mottagning inom Stockholms läns landsting. Barnen/ familjerna randomiserades till TA-C respektive traditionell utredning (TU). Den totala behandlingstiden utvärderades i de båda grupperna. Föräldra- skattning med ”Strengths and Difficulties Questionnaire” (SDQ), ”Outcome Rating Scale” (ORS) och ”Session Rating Scale (SRS). Dessutom barnskattning med Child Outcome Rating Scale (CORS) och Child Session Rating Scale (CSRS) samt kliniker bedömde global funktionsnivå med Children´s Global Assessment Scale (C-GAS) före och efter utredning. Resultat: Utredningstiden för TA-C gruppen var 68 dagar med i medeltal 11 sessioner och för TU gruppen 60 dagar med i medeltal 7,5 sessioner. Livstillfredsställelsen mätt med självskattningsformulären ORS och CORS var signifikant högre hos både föräldrarna och barnen vid genomförd TA-C jämfört med TU. Däremot uppvisade inte grupperna signifikanta skillnader i global funktionsnivå (CGAS), psykiatriska symtom (SDQ) eller i den självskattade alliansen mellan terapeut och föräldrar mätt med Session Rating Scale (SRS) eller mellan terapeut och barn mätt med Children Session Rating Scale (CSRS). Konklusion: I denna randomiserade kontrollerade pilotstudie av utredningsmetoden TA-C jämfört med TU framkom att TA-C gav ökad livstillfredsställelse hos både barnet och föräldrarna men inte förbättrad funktionsförmåga, psykisk symptomreduktion eller terapeutisk allians jämfört med TU. TA-C kan bidra till att skapa unika individ- och familjeanpassade åtgärdsförslag som bidrar till ökad livstillfredsställelse i vardagen vad gäller individuella och relationella aspekter hos både barnen och föräldrarna. Vi bedömer därför att TA-C har potential att fungera som ett värdefullt komplement till TU inom BUP.
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Brooks, Roslyn. "Therapeutic Narrative Illness Writing and the Quest for Healing." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/663.
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This thesis examines how narratives of illness become therapeutic narratives. The method is to engage closely with (mainly Australian) texts - literary accounts of illness - in order to identify key elements that effect a healing function (healing is distinguished from cure). Textual analysis is placed in the frame of medical information about the relevant conditions, and theoretical perspectives that provide a cultural and historical setting for illness writing. Bio-medical discourse foregrounds the clinical process of diagnosis, investigation and treatment and relegates the personal meanings of illness to secondary place. The thesis explores ways in which the patient's account provides an alternative discourse that supplements - and at times challenges - the medical discourse. Illness foregrounds the body, and illness narratives confront the reality of embodied experience. Illness that is chronic or incurable, ageing, physical and mental decline, and the inescapable prospect of death confront the patient with the need to find meaning in experience. Narratives of illness may serve as ventilation, diversion or escape for the patient. They may provide practical help, information and consolation to family and carers, and others who suffer with the condition. These are valuable functions, but I argue that illness writing may embody more powerful therapeutic elements that transform and give meaning to the illness as part of the individual's life story. Key therapeutic functions identified are perversity, empowerment and transformation. Healing can begin with the empowerment of telling one's story. Illness stories may challenge the stigma and the subordination associated with disease. They can affirm a sense of belonging and community where illness intersects with other forms of marginalization. Powerful illness narratives are often characterised by perversity, overturning the assumptions of dominant cultural discourses - including those that place authority with the medical practitioner and demand acquiescence from the patient. The most powerful therapeutic narratives transform the story of illness into a new story.
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Brooks, Roslyn. "Therapeutic Narrative Illness Writing and the Quest for Healing." University of Sydney. English, 2004. http://hdl.handle.net/2123/663.
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This thesis examines how narratives of illness become therapeutic narratives. The method is to engage closely with (mainly Australian) texts � literary accounts of illness � in order to identify key elements that effect a healing function (healing is distinguished from cure). Textual analysis is placed in the frame of medical information about the relevant conditions, and theoretical perspectives that provide a cultural and historical setting for illness writing. Bio-medical discourse foregrounds the clinical process of diagnosis, investigation and treatment and relegates the personal meanings of illness to secondary place. The thesis explores ways in which the patient�s account provides an alternative discourse that supplements � and at times challenges � the medical discourse. Illness foregrounds the body, and illness narratives confront the reality of embodied experience. Illness that is chronic or incurable, ageing, physical and mental decline, and the inescapable prospect of death confront the patient with the need to find meaning in experience. Narratives of illness may serve as ventilation, diversion or escape for the patient. They may provide practical help, information and consolation to family and carers, and others who suffer with the condition. These are valuable functions, but I argue that illness writing may embody more powerful therapeutic elements that transform and give meaning to the illness as part of the individual�s life story. Key therapeutic functions identified are perversity, empowerment and transformation. Healing can begin with the empowerment of telling one�s story. Illness stories may challenge the stigma and the subordination associated with disease. They can affirm a sense of belonging and community where illness intersects with other forms of marginalization. Powerful illness narratives are often characterised by perversity, overturning the assumptions of dominant cultural discourses � including those that place authority with the medical practitioner and demand acquiescence from the patient. The most powerful therapeutic narratives transform the story of illness into a new story.
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Andersson, Marie-Louise. "Leva med döden i rummet : Om terapeutisk behandling vid anorexi." Thesis, Södertörns högskola, Centrum för praktisk kunskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-33476.
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Syftet med denna kvalitativa studie är att närmare undersöka den fronetiska kunskapen kring vad det är iterapeutisk behandling som hjälper människor i riskzonen att utveckla eller redan har utvecklat långvariganorexi. Genom tre material – min teoretiska och praktiska kunskap och tidigare kvalitativa forskning, enfallstudie från den kliniska verksamheten vid Anorexiamottagningen i Stockholm samt en fältstudie medintervjuer med en forskare och fem terapeuter från två olika enheter. Denna studie utforskar gemensammanämnare i behandling med särskilt fokus på vikten av terapeuternas perspektiv. Informanterna har ett holistisktperspektiv och arbetar med olika existentiella, integrativa och systemiska modeller. Det som står ut iinformanternas svar, och som bekräftas av familjen och klientens egen röst, är att personen bakom symtomentonas fram – särskilt inför sig själv – och att sjukdomen tonas ner. Viktigt är också att terapeuterna kan förmedlabåde sin tro på att det är en mänsklig möjlighet att bli fri från anorexi och att det även finns anledning att tro påden enskilda klientens möjligheter att återhämta sig. Andra teman av betydelse är hur man hanterar ångest,negativa självbilder, ambivalens och rädsla för förändring och hur man inviterar till reflexion över alternativasätt att komma vidare i livet utan sin ”bästa” vän Anorexia. Denna studie föreslår mitt material och familjernasberättelse och informanternas bidrag tillsammans frambringar en kollektiv fronetisk kunskap. Det öppnar för attfortsatt forskning går vidare med de aspekter som diskuteras i slutreflektionen.The aim of hisqualitative study is to examine more closely the fronetic knowledge of what it is in a therapeutic treatment thathelps people who are on the edge to develop, or already have developed, long term anorexia. Through threematerials –my own theoretical and practical knowledge and previous qualitative research, one case study fromthe clinical praxis at the Anorexiamottagningen in Stockholm and one field study where one researcher and fivetherapists from two different unities are interviewed. The study has explored common denominators in treatmentwith special focus on the importance of the therapists ́ perspective. All informants have a holistic view and workwith different existential, integrative and systemic models. What stands out in the answers of the informants, andis confirmed by the family and the voice of the client, is that the person behind the symptoms is tuned up –especially for herself – and the illness is downplayed. It is also important that the therapists can mediate boththeir belief that it is a human possibility to become free from anorexia and that there is also good reason tobelieve in the possibility for the individual client to recoup. Other themes of importance are how to deal withanxiety, ambivalence, negative self-images and fear of change, and how to invite to reflection on alternativeways to proceed in life without their “best” friend, Anorexia. This study suggests that my material together withthe account of the family and the contribution of the informants at the treatment units and bring forth aconsiderable amount of collective phronetic knowledge. This suggests that future research look further into someof the aspects discussed in the final reflection.
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Sibole, Janet Marie. "Induction and expression of cocaine-induced behavioral sensitization: Modulation by a partial D₂-like agonist." CSUSB ScholarWorks, 2003. https://scholarworks.lib.csusb.edu/etd-project/2438.
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The purpose of this study was to investigate whether a partial D₂-like dopamine agonist (i.e. terguride) would block the induction or expression of cocaine-induced behavioral sensitization in pre-weanling rats. The ability of terguride to induce behavioral sensitization was also examined, as partial D₂-like agonists have agonistic actions in cases of low dopaminergic tone.
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Fatemi, Jaleh. "An exploratory study of peak experience and other positive human experiences and writing." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1368.
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This study analyzes and reports on the characteristics of writing-triggered
peak experience and other positive human experiences and explores some
possible factors that can bring about such moments. Three basic questions were
explored: Can writing trigger peak experience and other positive human
experiences? How are writing-triggered peak experience and other positive
human experiences best described? What factors influence the occurrence of
writing-triggered peak experience and other positive human experiences?
Participants were asked to write about their happiest moment in writing. The
sample consisted of 270 students enrolled in undergraduate writing classes at a
major southwestern university. Of 270 participants, 119(44%) reported having
had at least one peak experience or similar positive human experience as a result
of writing. Protocols reporting peak experience and other positive human
experiences in writing were analyzed for content, yielding a total of 14 descriptive
attributes. The participants described their writing experiences as flow of the
words, the process of writing is its own reward, peak performance, clarity,
disappearance of negative states of mind, and enhanced sense of power and
personal worth. Content analysis also yielded 13 possible triggers of peak
experience and other positive human experiences including self-expression,
realization, free writing, use of writing for introspection, and creative and
inspirational writing. In addition, personal orientation was explored as a possible
trigger of peak experience and other positive human experiences using a 16-item
questionnaire.
Factor analysis results yielded four factors: (1) aesthetic creative expressive
writing, (2) writing as a thinking and problem solving tool (3) self-discovery, and
(4) not interested in writing. Factor one accounted for the highest variance (37%).
The common elements in this factor were expressive writing, self-related writing
and creative poetic writing with poetic and creative writing having the highest
loading.
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Pompa, Marilyn. "Frequency and perception of the utilization of therapuetic communication skills among student nurses /." Staten Island, N.Y. : [s.n.], 1988. http://library.wagner.edu/theses/nursing/1988/thesis_nur_1988_pompa_frequ.pdf.
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Gopinath, Puja Gopinath. "A Review of Pricing and Reimbursement for Abeona Theraputics’ Gene Therapy Products to Treat Sanfilippo Syndrome." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1497024647261096.
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Joshi, Padmanabh B. "Development of Optically Active Nanostructures For Potential Applications in Sensing, Therapeutics and Imaging." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439307315.
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Thomas, Wendy Anne. "Addressing the need for school based support for bereavement and loss : perceptions, experiences and intervention." Thesis, University of Exeter, 2010. http://hdl.handle.net/10036/117541.
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Phase One: Effects of loss on the emotional health and well-being of children are wide-ranging and increase the risk of longer term impact on educational success and mental health (McLanahan 1999; Abdelnoor & Hollins 2004a). As frontline workers, school staff hold a role in identifying and supporting pupils at a universal level. How staff view the issue of loss and their role in supporting this is therefore pivotal. A survey design using two devised online questionnaires and semi-structured interviews identifies the experiences and perceptions of school based staff on the issue of loss for schools in one local authority. Using interactive analysis, qualitative and quantitative data from senior leaders in 20 schools, 25 additional school staff members and 9 multi-agency professionals is triangulated to determine perceptions. A range of effects across social, emotional, behaviour and learning are well recognised by staff although behaviour is used as the most frequent indicator of those at longer term ‘risk’. A more structured and rigorous school response exists for loss through death compared to family breakdown despite some specific staff concerns for pupils experiencing loss through multiple changes in the family. Whilst staff members indicate a high expectation to support pupils with loss, they report lower confidence in doing so. A series of influencing factors on staff perceptions are identified at a contextual, situational and individual level. Factors that could be targeted by Educational Psychology Service to help schools build capacity are highlighted, with future considerations for support with identification, training and supervision. Abstract: Phase Two: This second phase of a two part research design investigates how an Educational Psychology Service can increase the capacity of schools to support pupils who have experienced loss. Following a survey design identifying staff attitudes on the issue of loss for schools, a multi-method case study approach is used to research the implementation of a 6-week ‘Loss and Change’ intervention programme. Seven secondary age students participated in the group intervention for pupils who have experienced loss, facilitated by two Educational Psychologists working alongside a member of school staff. A grounded theory approach analysed data from observation, semi-structured interviews and self-report measures. Eight key processes that impact on the effectiveness of the programme are identified and the positive effects spanning social, emotional and behavioural mechanisms are reported for six of the participants. Potential implications of this model of practice for Educational Psychology Services seeking to develop the capacity of schools to support loss are discussed.
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Blackwell, Ophelia M. "The dynamic shift in therapeutic relationships through counselor self-disclosure with military client: a case study." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38270.
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Doctor of PhilosophyDepartment of Special Education, Counseling and Student Affairs
Kakali Bhattacharya
Doris W. Carroll
This qualitative case study is designed to explore how two participants described their role with their use of counselor self-disclosure in establishing and maintaining therapeutic alliance with military clients. Utilizing purposeful and criterion-based sampling, participants for this study were counselors who worked with the military populations, had independent practices, and believed that counselor self-disclosure was beneficial in building strong therapeutic alliances with military clients. Informed by Symbolic Interactionism, the participants’ understanding of self-disclosure and its role in establishing and maintaining therapeutic alliance with military clients were explored through semi-structured, in-depth, open-ended interviews. Counselor self-disclosure (CSD) is a technique that helps to establish strong therapeutic alliances and break down barriers that may exist between the military population and their counselors. Some military members experience mental health disorders following deployments. However, these military members experience barriers when seeking treatment and they commonly terminate treatment prematurely. Findings indicate that when counselors use self-disclosure it inspires participants to open up and model their counselor’s behavior. Moreover, military clients become aware of their own symptoms that were previously invisible to them, and find ways to relate and trust the counselor. Conversely, findings also indicate that CSD can be used improperly or even when used properly could have undesired effects such as causing ruptures in the therapeutic relationship due to a lack of clients’ openness, or perceiving CSD unprofessional and an inauthentic way to elicit therapeutic alliance. This study has implications for counselor educators and practitioners to consider training about relationally-oriented cultural practices that help to prevent ruptures in therapeutic alliances with military clients. Another implication is about how CSD could be used in the preparation of students in counselor education training programs and how more inquiry could be conducted to document systematic data about the influence of CSD on therapeutic alliance. Finally, the study has implications about how CSD can facilitate support for military clients and critically understanding how CSD can aid in supporting retention or loss of treatment for military clients.
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Onions, Caryn Jane. "'This shared parenting we do is difficult to get your head around' : experiences of parents and carers during their child's first year at a residential therapuetic special school : a qualitative study." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/28082.
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This research examined the impact on parents and carers of having a child placed at a residential special school for abused, neglected and traumatised primary aged children. The school is developing its work with families and carers, because if relationships at home are improved, children are more likely to benefit from the placement at Stowbury. Although it is the child who is referred, establishing a good working relationship with parents and carers is vital in helping them with their child’s return home. The study focused on parental experiences of the child’s first year at the school, using interviews at the start of placement and then twelve months later. The data were analysed using a comparative thematic analysis at two time points and a secondary narrative analysis. Researcher reflexivity is used and where appropriate the findings are discussed from a psychoanalytic perspective. The analysis found that during the first year the children make positive changes. Birth parents were helped with their parenting, particularly the (re)establishment of parental boundaries. In contrast, some foster carers found it difficult to share the parenting role, and tensions between home and school were identified. Some parents and carers found it difficult to reflect on their role and relationship with their child. In general, parents and carers expected their child to be able to go to mainstream school when they left Stowbury, and after one year some realised that was unlikely. The study concludes that the experience of foster carers could be improved if they were helped to increase their ability to reflect on their parenting role. In addition, sharing the parenting of this group of children can cause tension between parents, carers and staff. There are training implications for the professionals involved. This research makes an original contribution to knowledge about the psychodynamics that develop in the relationships between the parents, carers and staff looking after abused children in a residential school.
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Doshi, Kunal Jayant. "Creative new visualization and human interface devices for theraputic video games." Thesis, 2008. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2008-012.
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"Construction of a Recombinant Immunotoxin." University of Technology, Sydney. Faculty of Science, 1995. http://hdl.handle.net/2100/270.
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In recent years a number of therapeutically useful immunotoxins have been produced using recombinant gene technology. In general, this involves fusion of a toxin gene with sequence encoding a variety of clinically relevant proteins or peptides. Using these techniques a recombinant immunotoxin has been engineered by fusing the genes encoding an antibody fragment with the sequence of a small cytolytic peptide, melittin. The antibody fragment consists of the antigen binding site derived from a murine monoclonal antibody K- 1-21, which binds to human free kappa light chains and recognises a specific epitope (KMA) expressed on the surface of human myeloma and lymphoma cells. The toxic portion of the molecule is melittin, a 26 amino acid, membrane lytic peptide which is a major component of bee venom. Using PCR a single chain Fv (scFv) was constructed by linking VH and VL genes with an oligonucleotide encoding a flexible, hydrophilic peptide. The melittin gene was synthesised as an oligonucleotide and extended by PCR. Nucleotide sequence encoding a linker peptide was added to the 5' end and a primer encoding a FLAG peptide was used to extend the 3' end. This gene construct was then ligated into the recombinant expression vector, pPOW scFv, to create the fusion gene encoding the recombinant immunotoxin. The gene construct was expressed in the periplasm of E.coli (TOPP2) using the secretion signal pelB . Expression of the foreign protein was monitored by western blot using a monoclonal antibody which recognises the FLAG peptide encoded at the carboxy terminal region of the gene construct. Expression of the recombinant immunotoxin was optimised and the resulting protein was purified using anti-FLAG M2 affinity chromatography. Antigen binding activity was assessed by ELISA and flow cytometry using a human myeloma cell line, HMy2, which expresses the KMA antigen.Binding of the immunotoxin to a control human cell line, K562, which does not express KMA on the cell surface was also assessed. The results indicated that the recombinant immunotoxin retained antigen binding specificity and it was cytotoxic towards the target cell line (HMy2).
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Cho, Min-hee. "Pharmacokinetics, hepatic extraction, and renal disposition of phosphorothioate oligodeoxynucleotides." 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3077622.
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Pilgrim, Shea McNeill. "Child and parent experiences of neuropsychological assessment as a function of child-centered feedback." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-08-1547.
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Research has paid little attention to clients’ experience of the psychological assessment process, particularly in regard to the experiences of children and their parents. Advocates of collaborative assessment have long espoused the therapeutic benefits of providing feedback that can help clients better understand themselves and improve their
lives (Finn & Tonsager, 1992; Fischer, 1970, 1985/1994). Finn, Tharinger, and colleagues (2007; 2009) have extended a semi-structured form of collaborative assessment, Therapeutic Assessment (TA), with children. One important aspect of their method, drawn from Fischer’s (1985/1994) example, is the creation of individualized fables that incorporate assessment findings into a child-friendly format. The fables are then shared with the child and parents as assessment feedback. This study evaluated whether receiving this type of individualized, developmentally appropriate feedback would affect how children and their parents report experiencing the assessment process. The assessment process, with the exception of child feedback, was standard for the
setting. Participants were 32 children who underwent a neuropsychological evaluation at
a private outpatient clinic, along with their parents. Multivariate and univariate statistics
were used to test differences between two groups: an experimental group that received
individualized fables as child-focused feedback and a control group. Children in the
experimental group reported a greater sense of learning about themselves, a more positive
relationship with their assessor, a greater sense of collaboration with the assessment process, and a sense that their parents learned more about them because of the assessment than did children in the control group. Parents in the experimental group reported a more
positive relationship between their child and the assessor, a greater sense of collaboration
with the assessment process, and higher satisfaction with clinic services compared to the
control group. Limitations to the study, implications for assessment practice with children, and future directions for research are discussed.text
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"Construction of a recombinant immunotoxin." Thesis, University of Technology, Sydney. Faculty of Science, 1995. http://hdl.handle.net/10453/20069.
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University of Technology, Sydney. Faculty of Science.In recent years a number of therapeutically useful immunotoxins have been produced using recombinant gene technology. In general, this involves fusion of a toxin gene with sequence encoding a variety of clinically relevant proteins or peptides. Using these techniques a recombinant immunotoxin has been engineered by fusing the genes encoding an antibody fragment with the sequence of a small cytolytic peptide, melittin. The antibody fragment consists of the antigen binding site derived from a murine monoclonal antibody K- 1-21, which binds to human free kappa light chains and recognises a specific epitope (KMA) expressed on the surface of human myeloma and lymphoma cells. The toxic portion of the molecule is melittin, a 26 amino acid, membrane lytic peptide which is a major component of bee venom. Using PCR a single chain Fv (scFv) was constructed by linking VH and VL genes with an oligonucleotide encoding a flexible, hydrophilic peptide. The melittin gene was synthesised as an oligonucleotide and extended by PCR. Nucleotide sequence encoding a linker peptide was added to the 5' end and a primer encoding a FLAG peptide was used to extend the 3' end. This gene construct was then ligated into the recombinant expression vector, pPOW scFv, to create the fusion gene encoding the recombinant immunotoxin. The gene construct was expressed in the periplasm of E.coli (TOPP2) using the secretion signal pelB . Expression of the foreign protein was monitored by western blot using a monoclonal antibody which recognises the FLAG peptide encoded at the carboxy terminal region of the gene construct. Expression of the recombinant immunotoxin was optimised and the resulting protein was purified using anti-FLAG M2 affinity chromatography. Antigen binding activity was assessed by ELISA and flow cytometry using a human myeloma cell line, HMy2, which expresses the KMA antigen.Binding of the immunotoxin to a control human cell line, K562, which does not express KMA on the cell surface was also assessed. The results indicated that the recombinant immunotoxin retained antigen binding specificity and it was cytotoxic towards the target cell line (HMy2).
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Ernst, Anthony Joseph. "The client's perspective of naltrexone phamacotherapy a qualitative study /." 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3077636.
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Rodrigues, Miguel Alexandre Tomás. "New Theraputics of Hepatocellular Cancer." Master's thesis, 2018. http://hdl.handle.net/10316/82262.
Full textAbstract:
Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de MedicinaO carcinoma hepatocellular constitui a 6º maior causa de morte por neoplasia malignaa nível mundial. Para além de estar relacionado com uma elevada taxa de mortalidade estátambém relacionado com uma elevada taxa de morbilidade, apesar dos meios despendidos naprevenção e vigilância da doença.Esta patologia relaciona-se com inúmeros fatores, desde os hábitos alimentares,contacto com químicos na carreira profissional, causas infeciosas viral ou fúngica e a genética individual que podem ser manipulados de forma a reduzir a probabilidade dedesenvolvimento da doença e afetar o seu curso. Apesar de ser associada com os países desenvolvidos, países em desenvolvimento também estão em risco.A resseção hepática continua a ser a opção tradicional no tratamento do carcinomahepatocelular. Contudo, avanços na biologia molecular e em técnicas de intervençãopercutânea abriram um caminho para que outros tratamentos apresentem opções comcaraterísticas mais apropriadas a uma variedade de cenários de doença. Especiais entre estes avanços são aqueles feitos na sinalização molecular e na identificação de pontos de verificação na divisão celular das metástases. Novas drogas com alvo nestes pontos de verificação e novos esquemas de fármacos bem como operações percutâneas alternativas estão a ser desenvolvidos com base nos novos conhecimentos da doença. A pesquisa imunológica também desempenha um papel importante nestes estudos.O objetivo deste estudo é rever os novos tratamentos disponíveis contra o carcinomahepatocelular integrados no campo do conhecimento corrente da doença.
Hepatocellular carcinoma is the sixth largest cause of death due to malignant neoplasiaworldwide. In addition to being related to a high mortality rate, it is also related to a highmorbidity rate, despite the means spent on disease prevention and surveillance.This pathology relates to numerous risk factors, from eating habits, contact withoccupational chemicals, infections, viruses and fungi and individual genetics, that can bemanipulated in a way that reduces the likelihood of disease development and affects itscourse. Despite being associated with the more developed countries, countries in develepoment are also at risk.Hepatic resection remains the traditional choice in the treatment of hepatocellularcarcinoma. However, advances in molecular biology, the knowledge of the molecularmechanisms involved and the development of percutaneous intervention techniques havepaved the way for other treatments to present options with features more appropriate to avariety of disease scenarios. Special amongst this advances are the ones made in molecular signalling and identification of cellular checkpoints in the cellular divison of metastasis. New drugs that target these checkpoints and new drug schemes as well as alternative percutaneous operations are being developed based on the new knowledge of the disease. Immunologic research also plays an important role in these studies.The objective of this study is to review the new treatments available against hepatocellular carcinoma integrated in the frame of current knowledge about the disease.
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(8803034), Yifan Kong. "IMPROVEMENT OF TREATMENT FOR PROSTATE CANCER AND PLK1’S ROLE IN NON-SMALL-CELL LUNG CARCINOMA." Thesis, 2020.
Find full textAbstract:
Prostate cancer (PCa) is the second leading cause of cancer related deaths in American men. In this study, I identify two combinational therapeutics to treat PCa – the combination of enzalutamide and simvastatin, and the combination of GSK126 and metformin, both of which strongly suppress PCa cell growth in vitro and in vivo via inhibiting androgen receptor (AR), an important oncogenic driver for the PCa progression. Simvastatin leads to more AR degradation when combined with enzalutamide. For the combination of GSK126 and metformin, the interaction between enhance of zeste homolog2 (EZH2) and AR is interrupted by GSK126, re-sensitizing EZH2 to metformin. Meanwhile, GSK126 inhibits EZH2’s activity.
Polo-like kinase 1 (PLK1), a cell cycle regulator, is usually overexpressed in non-small-cell lung cancer (NSCLC). Here, we report that PLK1 overexpression promotes the development of KrasG12D and Trp53fl/fl (KP)-driven lung adenocarcinoma (LADC). KP mice harboring transgenic PLK1 (KPPI) display heavier tumor burden, poorer tumor differentiation, and lower survival than KP mice. Mechanistically, PLK1 overexpression enhances the activity of MAPK pathway, via upregulating RET expression in a kinase-dependent manner. Supporting our findings, PLK1 knockout in KP mice reduces RET gene expression, inhibits MAPK pathway activity, and strongly delays LADC development. Therefore, these data reveal that PLK1 functions as an oncogene in KP-driven LADC.
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Breytenbach, Frieda. "Diagnostiese waarde van klei as projeksiemedium." Thesis, 2009. http://hdl.handle.net/10500/3368.
Full textAbstract:
Text in Afrikaanshe goal of this research study is to determine whether clay has any diagnostic value to the Educational Psychologist. The phenomenon of claywork with children has been examined by literature to determine whether this subject has been researched before. The developmental phases in claywork and the development of clayfigures are discussed, as well as the clay techniques which are applied by children. A comparison between clay as a three-dimensional medium and drawings as two-dimensional medium is made. The ways of application of clay are discussed by means of case studies. The general value of clay for the Educational Psychologist is also mentioned. On the grounds of certain short-comings in the literature study, "The Clay-feelingstory technique" is initiated and applied. For the empirical study eighty learners in the foundation phase, aged between five and nine years, were involved. Random sampling was used. This research study uses the combined method design in order to better understand the phenomenon of clay projections. Although the study is mainly qualitative in nature, some data is quantified. The research results prove that clay projections have diagnostic value, concerning the child's verbal and non-verbal messages, the way he applies clay techniques, by decoding his symbolic messages, emotions come to the fore, actions are portrayed and described, relations are revealed, themes come to the fore and needs are expressed. It also seems that clay projections can be taken in group context as an identification medium to help the child in need. It also seems that clay projections can be applied as a supplementary projection medium and that hypothesis can be verified with other exploratory media. Guidelines are given for the application and interpretation of clay as projection medium.
Educational Studies
D.Ed. (Sielkundige Opvoedkunde)
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Jennings, Kenneth E. "Towards a model of mental preparation in elite sport." Thesis, 1997. http://hdl.handle.net/10500/17010.
Full textAbstract:
This study examines the mental preparation of elite athletes
using naturalistic action research. The focus of investigation
was on the personal difficulty of dealing with the "expert
issue" that existed in the consultative relationship.
The unfolding research experience confronted the researcher
with personal dilemmas that needed to be resolved; activating
significant shifts in the direction of exploration. These shifts
were triggered in conversational contexts, highlighting the
impact of co-evolved intimate sharing.
Quantum leaps in understanding occurred when the researcher;
(a) realised that a research proposal had been formulated that
was not congruent with ecosystemic philosophies, (b) discovered
action research, thereby shifting from an isolated
self-reflective position to embracing the phenomenon of shared
inquiry, (c) formed an action research group to investigate
consultative issues, (d) became aware that the action research
process was a reflection of an individual's unique idiosyncratic
interactive and thinking style, (e) had to deal with the impact
of a work experience as the action group turned into a
therapeutic team, and (f) aligned himself to a narrative writing
style to formally report on the "fluid", "free-flow"
conversational experiences that had occurred in the research
context.
"Reflective interactive exploration"
written methodology to capture the ideas
emerged as a formal
that evolve
conversation. This methodology became the vehicle to
during
(a) shift
more responsibility onto the athlete to become the "researcher
of self", (b) open up further conversation, and (c) to relieve
the psychologist of the expert position. The methodology was
also utilised in the action research group to explore issues and
to exchange ideas with the supervisor.
The theory of the "mask of competency" of the athlete
existing in a "culture of competition" is forwarded. A
therapeutic model that balances intervention techniques with
therapeutic conversation is suggested when consulting with
athletes. Therapeutic conversation is broadened to incorporate
concepts such as "energy flow", "obstacles and resistances" and
"connection and intimacy".
The personal "expert issue" was found to be a "reflection"
of the researcher's own unique perceptions and interactive
tendencies. Addressing issues at this level of personal identity
required special interpersonal conditions; a context of
respectful, intimate conversation.Psychology
D. Litt. et Phil. (Psychology)