Academic literature on the topic 'Thérapie par capture de neutrons par le bore'
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Journal articles on the topic "Thérapie par capture de neutrons par le bore":
Pignol, JP, JC Abbé, J. Sahel, A. Methlin, and G. Methlin. "Thérapie par capture de neutrons." Journal de Chimie Physique 91 (1994): 1243–53. http://dx.doi.org/10.1051/jcp/1994911243.
Colomb, F., and G. Ermont. "Étude d'un filtre de neutrons épithermiques pour la thérapie par capture de neutrons : validation expérimentale de la simulation Monte Carlo." Journal de Chimie Physique et de Physico-Chimie Biologique 95, no. 4 (April 1998): 698–702. http://dx.doi.org/10.1051/jcp:1998181.
Dissertations / Theses on the topic "Thérapie par capture de neutrons par le bore":
Maguer, Aude. "Manipulation et fonctionnalisation de nanotube : Application aux nanotubes de nitrure de bore." Phd thesis, Paris 11, 2007. http://www.theses.fr/2007PA112215.
This PhD work is divided into two parts dealing with boron nitride (BNNT) and carbon nanotubes. The first part is about synthesis, purification and chemical functionalization of BNNT. Single-walled BNNT are synthesized by LASER ablation of a hBN target. Improving the synthesis parameters first allowed us to limit the byproducts (hBN, boric acid). A specific purification process was then developed in order to enrich the samples in nanotubes. Purified samples were then used to develop two new chemical functionalization methods. They both involve chemical molecules that present a high affinity towards the BN network. The use of long chain-substituted quinuclidines and borazines actually allowed the solubilization of BNNT in organic media. Purification and functionalization were developed for single-walled BNNT and were successfully applied to multi-walled BNNT. Sensibility of boron to thermic neutrons finally gave birth to a study about covalent functionalization possibilities of the network. The second part of the PhD work deals with separation of carbon nanotubes depending on their properties. Microwave irradiation of carbon nanotubes first allowed the enrichment of initially polydisperse samples in large diameter nanotubes. A second strategy involving selective interaction between one type of tubes and fullerene micelles was finally envisaged to selectively solubilize carbon nanotubes with specific electronic properties
El, hajj Zeinab. "Synthesis and characterization of new hybrid polyoxometalates for photocatalytic and biological applications." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASF078.
The development of a novel class of multifunctional POM hybrids, denoted as ″SiW10-B10-Organic ligand" starting from the POM-Borate precursor ″SiW10-monoB10", has been investigated for biological applications. The latter resulted from the reaction of the carbonyl group of closo-decahydrodecaborate anion [B10H9CO]- with one of the two pendant amine groups of the organic linker 3-(Aminopropyl)triethoxysilane (APTES), which is covalently attached to the POM Keggin-type polyoxometalate [SiW10O36]2-.Herein, we aimed to go further by functionalizing the second amine function of SiW10-monoB10.The mono-adduct ″SiW10-monoB10” compound was firstly synthesized with good purity and in sufficient quantities, then characterized by atypical 1H-15N HMQC NMR, which allowed the examination of the nature of the free amine function and showed the presence of non-zero amine fraction that would not be involved in the H-H interaction with the decaborate cluster. Consequently, the possibility of new functional groups on this free amino arm of SiW10-monoB10 adduct was tested and followed through 1H and 11B NMR. Despite our best efforts and the various strategies, we have investigated, the studies carried out show that interactions with the POM part and with B-H groups are preferential to the formation of the covalent bonds we had hoped for.In the following section, we turned our attention to other hybrid POMs used as photoinitiators. Anthracene-, benzophenone- and anthraquinone-based derivatives were respectively covalently grafted onto the polyoxometalate (POM) platform [Mo6O19]2-, giving rise to highly colored organo-imido Lindqvist complexes: POM-imidoanthraquinone (POM-AQ), POM-imidoanthracene (POM-AC), and POM-imidobenzophenone (POM-AB). It has been evidenced that photosystems combining N-methyldiethanolamine (MDEA) as electron donor and these hybrid POMs promote free-radical photopolymerization of acrylate monomer derivatives under irradiation in the visible range, while in similar conditions, no polymerization was observed considering when adding each of the hexamolybdate cluster or the organic entity alone with the MDEA and acrylate monomers. Such organo-imido Lindqvist species can represent new, easy-to-synthesize, efficient visible-light photoinitiators. Moreover, due to the presence of the POM, coatings prepared using the POM-AQ/MDEA/Soybean oil epoxidized acrylate photosystem exhibit excellent mechanical properties, with very good flexibility, resistance to brittle fracture, and adherence to the steel.In the last chapter, the preparation of new closo-borate/CD inclusion complexes has been studied to elaborate systems strong enough to be considered for biological application. Playing on the volume and charge of [B10H10]2- was set out to increase their chaotropic character and thus enhance their binding affinity to cyclodextrins. The encapsulation of [B10H9NCCH3]- and [B20H18]2- anions within cyclodextrins has been investigated in two different parts. ESI-MS and NMR evidenced the formation of inclusion complexes between the borate compounds and beta- and gamma-CDs, while weaker interactions are evidenced with alpha-CD, for which the binding constants were determined by NMR and ITC. These constant values are much higher than those obtained in previous work with [B10H10]2- thus validating the approach followed in this thesis work.A new approach in [B20H18]2- chemistry has also been studied at the end of the work related to the Hydrogen-Deuterium exchange process in [B20H18]2- aqueous solution.1H{11B} and 11B{1H} NMR evidenced selective deuterium-proton exchange processes with the protons of equatorial Boron atoms over a period of time with the presence of degradation. Interestingly, it has been shown through NMR of [B20H18]2-/CD solutions in D2O that beta- and gamma-CDs would protect the anion from degradation after 4-5 months, opening the route for designing Boron-based drugs with enhanced stability suitable for medical use
Bourhis, Emmanuelle. "Application de codes Monte Carlo à la dosimétrie de la potentialisation par capture de neutrons par le bore 10 mise en œuvre en radiothérapie du cancer." Nice, 2000. http://www.theses.fr/2000NICE5479.
Laurent-Pettersson, Maria. "Etude de complexes du bore en vue d'une application thérapeutique : utilisation de traceurs isotopiques stables du bore et de l'azote, détectés par « radiographie par capture de neutrons »." Rouen, 1992. http://www.theses.fr/1992ROUES005.
Martin, Bénédicte. "Vectorisation tumorale d'isotopes par les polyamines à des fins diagnostiques et thérapeutiques." Rennes 1, 2001. http://www.theses.fr/2001REN10066.
Dehuyser, Laure. "Synthèse d'amphiphiles à base de carborane pour la thérapie par capture de neutrons par le 10B : synthèse de glycolipides pour l'inhibition de la trans-infection du VIH-1 et l'inhibition du virus de la Dengue." Strasbourg, 2011. http://www.theses.fr/2011STRA6262.
Sugars are implicated in numerous biological processes and take part in the immune response, cell proliferation, or viral and bacterial infections. Their contribution is essential for cellular recognition and the interactions between sugars and the membrane receptors enable one to influence biological responses. Therefore to target some types of receptors, amphiphiles bearing a mono or disaccharide polar head were developed and evaluated. In the first part, synthesis of photo-polymerizable amphiphiles incorporating carboranes are carried out for the Boron Neutron Capture Therapy (BNCT). Carboranes are polyhedral structures with a high content of boron atoms which enable the accumulation of sufficient quantities of boron for this therapy. These amphiphiles have been organized around carbon nanotubes to obtain stable dispersions; these nano-constructions, rich in boron for BNCT, can target tumor cells at the same time due to the sugars borne by the amphiphiles. The second part of this thesis consists in the evaluation of saturated or photo-polymerizable glycolipids for the inhibition of the trans-infection of HIV-1; the process of trans-infection involved the DC-SIGN receptor which is located on dendritic cell membranes. Multivalent effects of the micellar structures composed by these glycolipids was compared with the single amphiphile. This study investigated the effects of the length of the hydrophobic tail and the structure of the glycolipids polar head. Compounds bearing multivalent mannosylated head were identified as good candidates for inhibiting the trans-infection of HIV-1. These molecules were also tested for the inhibition of the Dengue virus and have shown good effects. Finally, this manuscript discusses the chemistry of carboranes and new functional molecules were developed for BNCT
Pignol, Jean-Philippe. "Application de la neutronographie à l'étude de la distribution de 10b dans les tissus biologiques : contribution a la "pharmacodosimétrie" et à la microdosimétrie en thérapie par capture de neutrons." Strasbourg 1, 1994. http://www.theses.fr/1994STR13169.